Marcus Michael Seldin

Title(s)Assistant Professor, Biological Chemistry
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6765
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    Collapse Research 
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    A strategy for discovery of endocrine interactions
    NIH R00HL138193Apr 3, 2018 - Nov 30, 2022
    Role: Principal Investigator
    Development of a strategy for endocrine axis discovery
    NIH K99HL138193Apr 3, 2018 - Mar 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. Sci Rep. 2021 Aug 12; 11(1):16409. Guo F, Seldin M, Péterfy M, Charugundla S, Zhou Z, Lee SD, Mouton A, Rajbhandari P, Zhang W, Pellegrini M, Tontonoz P, Lusis AJ, Shih DM. PMID: 34385484.
      View in: PubMed   Mentions:    Fields:    
    2. CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data. Nucleic Acids Res. 2021 07 02; 49(W1):W104-W113. Molendijk J, Seldin MM, Parker BL. PMID: 33978718.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. Eur Heart J. 2021 03 01; 42(9):919-933. Hartiala JA, Han Y, Jia Q, Hilser JR, Huang P, Gukasyan J, Schwartzman WS, Cai Z, Biswas S, Trégouët DA, Smith NL, INVENT Consortium , CHARGE Consortium Hemostasis Working Group , GENIUS-CHD Consortium , Seldin M, Pan C, Mehrabian M, Lusis AJ, Bazeley P, Sun YV, Liu C, Quyyumi AA, Scholz M, Thiery J, Delgado GE, Kleber ME, März W, Howe LJ, Asselbergs FW, van Vugt M, Vlachojannis GJ, Patel RS, Lyytikäinen LP, Kähönen M, Lehtimäki T, Nieminen TVM, Kuukasjärvi P, Laurikka JO, Chang X, Heng CK, Jiang R, Kraus WE, Hauser ER, Ferguson JF, Reilly MP, Ito K, Koyama S, Kamatani Y, Komuro I, Biobank Japan , Stolze LK, Romanoski CE, Khan MD, Turner AW, Miller CL, Aherrahrou R, Civelek M, Ma L, Björkegren JLM, Kumar SR, Tang WHW, Hazen SL, Allayee H. PMID: 33532862.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. 2021 05 04; 143(18):1809-1823. von Scheidt M, Zhao Y, de Aguiar Vallim TQ, Che N, Wierer M, Seldin MM, Franzén O, Kurt Z, Pang S, Bongiovanni D, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic JC, Mann M, Björkegren JLM, Lusis AJ, Yang X, Schunkert H. PMID: 33626882.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    5. Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Mol Syst Biol. 2021 01; 17(1):e9684. Norheim F, Chella Krishnan K, Bjellaas T, Vergnes L, Pan C, Parks BW, Meng Y, Lang J, Ward JA, Reue K, Mehrabian M, Gundersen TE, Péterfy M, Dalen KT, Drevon CA, Hui ST, Lusis AJ, Seldin MM. PMID: 33417276.
      View in: PubMed   Mentions: 1     Fields:    
    6. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020 08 06; 182(3):545-562.e23. Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. PMID: 32621799.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    8. FAM13A affects body fat distribution and adipocyte function. Nat Commun. 2020 03 19; 11(1):1465. Fathzadeh M, Li J, Rao A, Cook N, Chennamsetty I, Seldin M, Zhou X, Sangwung P, Gloudemans MJ, Keller M, Attie A, Yang J, Wabitsch M, Carcamo-Orive I, Tada Y, Lusis AJ, Shin MK, Molony CM, McLaughlin T, Reaven G, Montgomery SB, Reilly D, Quertermous T, Ingelsson E, Knowles JW. PMID: 32193374.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Systems genetics applications in metabolism research. Nat Metab. 2019 11; 1(11):1038-1050. Seldin M, Yang X, Lusis AJ. PMID: 32259026.
      View in: PubMed   Mentions:
    10. Sex-specific metabolic functions of adipose Lipocalin-2. Mol Metab. 2019 12; 30:30-47. Chella Krishnan K, Sabir S, Shum M, Meng Y, Acín-Pérez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Péterfy M, Reue K, Liesa M, Lusis AJ. PMID: 31767179.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    11. Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism. Mol Metab. 2019 06; 24:44-63. Geoghegan G, Simcox J, Seldin MM, Parnell TJ, Stubben C, Just S, Begaye L, Lusis AJ, Villanueva CJ. PMID: 30948248.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    12. An integrative systems genetic analysis of mammalian lipid metabolism. Nature. 2019 03; 567(7747):187-193. Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. PMID: 30814737.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    13. Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits. Cell Metab. 2019 04 02; 29(4):932-949.e4. Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hofmann SM, Arnold AP, Lusis AJ. PMID: 30639359.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    14. Systems-based approaches for investigation of inter-tissue communication. J Lipid Res. 2019 03; 60(3):450-455. Seldin MM, Lusis AJ. PMID: 30617149.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    15. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67. Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. PMID: 30591411.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    16. Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans. G3 (Bethesda). 2018 11 06; 8(11):3499-3506. Lin LY, Chun Chang S, O'Hearn J, Hui ST, Seldin M, Gupta P, Bondar G, Deng M, Jauhiainen R, Kuusisto J, Laakso M, Sinsheimer JS, Deb A, Rau C, Ren S, Wang Y, Lusis AJ, Wang JJ, Huertas-Vazquez A. PMID: 30201759.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2016-2027. Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ. PMID: 30026271.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    18. Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet. 2018 07 15; 27(14):2586. Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis AJ, Pellegrini M. PMID: 29893869.
      View in: PubMed   Mentions: 4     Fields:    
    19. Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet. 2018 05 15; 27(10):1830-1846. Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis AJ, Pellegrini M. PMID: 29566149.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    20. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell Metab. 2018 May 01; 27(5):1138-1155.e6. Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ. PMID: 29719227.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    21. Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res. 2018 06 22; 123(1):73-85. Yu J, Seldin MM, Fu K, Li S, Lam L, Wang P, Wang Y, Huang D, Nguyen TL, Wei B, Kulkarni RP, Di Carlo D, Teitell M, Pellegrini M, Lusis AJ, Deb A. PMID: 29691232.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    22. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst. 2018 Jan 24; 6(1):103-115.e7. Chella Krishnan K, Kurt Z, Barrere-Cain R, Sabir S, Das A, Floyd R, Vergnes L, Zhao Y, Che N, Charugundla S, Qi H, Zhou Z, Meng Y, Pan C, Seldin MM, Norheim F, Hui S, Reue K, Lusis AJ, Yang X. PMID: 29361464.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    23. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. PMID: 29249357.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    24. C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. J Biol Chem. 2017 09 08; 292(36):14836-14850. Lei X, Seldin MM, Little HC, Choy N, Klonisch T, Wong GW. PMID: 28726640.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    25. Multi-omics approaches to disease. Genome Biol. 2017 05 05; 18(1):83. Hasin Y, Seldin M, Lusis A. PMID: 28476144.
      View in: PubMed   Mentions: 297     Fields:    Translation:Humans
    26. A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H728-H741. Seldin MM, Kim ED, Romay MC, Li S, Rau CD, Wang JJ, Krishnan KC, Wang Y, Deb A, Lusis AJ. PMID: 28235788.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    27. Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance. Glycobiology. 2017 01; 27(2):129-139. Lopez PH, Aja S, Aoki K, Seldin MM, Lei X, Ronnett GV, Wong GW, Schnaar RL. PMID: 27683310.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    28. Loss of CTRP5 improves insulin action and hepatic steatosis. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1036-52. Lei X, Rodriguez S, Petersen PS, Seldin MM, Bowman CE, Wolfgang MJ, Wong GW. PMID: 27143553.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    29. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 06; 57(6):925-42. Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. PMID: 27099397.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    30. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. J Am Heart Assoc. 2016 Feb 22; 5(2). Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. PMID: 26903003.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansAnimalsCells
    31. Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain. ASN Neuro. 2015 Sep-Oct; 7(5). Hubbard JA, Hsu MS, Seldin MM, Binder DK. PMID: 26489685.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    32. Dynamic Visualization of mTORC1 Activity in Living Cells. Cell Rep. 2015 Mar 17; 10(10):1767-1777. Zhou X, Clister TL, Lowry PR, Seldin MM, Wong GW, Zhang J. PMID: 25772363.
      View in: PubMed   Mentions: 38     Fields:    
    33. Thromboxane synthase deficiency improves insulin action and attenuates adipose tissue fibrosis. Am J Physiol Endocrinol Metab. 2015 May 01; 308(9):E792-804. Lei X, Li Q, Rodriguez S, Tan SY, Seldin MM, McLenithan JC, Jia W, Wong GW. PMID: 25738781.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 2015 Jan 06; 21(1):138-49. Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, Feinberg AP. PMID: 25565211.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    35. Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels. . 2014 Dec 15; 307(12):R1458-70. Petersen PS, Lei X, Seldin MM, Rodriguez S, Byerly MS, Wolfe A, Whitlock S, Wong GW. PMID: 25320344.
      View in: PubMed   Mentions:
    36. Seasonal oscillation of liver-derived hibernation protein complex in the central nervous system of non-hibernating mammals. J Exp Biol. 2014 Aug 01; 217(Pt 15):2667-79. Seldin MM, Byerly MS, Petersen PS, Swanson R, Balkema-Buschmann A, Groschup MH, Wong GW. PMID: 25079892.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    37. Metabolic function of the CTRP family of hormones. Rev Endocr Metab Disord. 2014 Jun; 15(2):111-23. Seldin MM, Tan SY, Wong GW. PMID: 23963681.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    38. CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice. PLoS One. 2014; 9(2):e88535. Peterson JM, Seldin MM, Tan SY, Wong GW. PMID: 24586339.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    39. C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem. 2014 Feb 14; 289(7):4055-69. Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E, Wei Z, Ronnett GV, Wong GW. PMID: 24366864.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    40. Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013 Dec 13; 288(50):36073-82. Seldin MM, Lei X, Tan SY, Stanson KP, Wei Z, Wong GW. PMID: 24187137.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    41. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. . 2013 Sep; 305(5):R522-33. Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S, Wong GW. PMID: 23842676.
      View in: PubMed   Mentions:
    42. CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 01; 305(3):G214-24. Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW. PMID: 23744740.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    43. A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. PLoS One. 2013; 8(4):e62862. Byerly MS, Swanson R, Wei Z, Seldin MM, McCulloh PS, Wong GW. PMID: 23638159.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    44. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. J Biol Chem. 2013 Apr 12; 288(15):10214-29. Wei Z, Seldin MM, Natarajan N, Djemal DC, Peterson JM, Wong GW. PMID: 23449976.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    45. Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. Adipocyte. 2012 Oct 01; 1(4):200-202. Seldin MM, Wong GW. PMID: 23700534.
      View in: PubMed   Mentions: 14     Fields:    
    46. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. J Biol Chem. 2012 Oct 19; 287(43):35804-14. Wei Z, Lei X, Seldin MM, Wong GW. PMID: 22942287.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    47. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012 Apr 06; 287(15):11968-80. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. PMID: 22351773.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    48. Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis. Exp Neurol. 2012 May; 235(1):246-55. Lee DJ, Hsu MS, Seldin MM, Arellano JL, Binder DK. PMID: 22361023.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    49. Aquaporin-4-dependent edema clearance following status epilepticus. Epilepsy Res. 2012 Feb; 98(2-3):264-8. Lee DJ, Amini M, Hamamura MJ, Hsu MS, Seldin MM, Nalcioglu O, Binder DK. PMID: 21996149.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    50. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010 Jun; 67(6):794-801. Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. PMID: 20517941.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
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