Marcus Michael Seldin

Title(s)Assistant Professor, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6765
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    Collapse Research 
    Collapse Research Activities and Funding
    Integrative approaches to dissection of endocrine communication
    NIH DP1DK130640Sep 17, 2021 - Jul 31, 2026
    Role: Principal Investigator
    A strategy for discovery of endocrine interactions
    NIH R00HL138193Apr 3, 2018 - Nov 30, 2022
    Role: Principal Investigator
    Development of a strategy for endocrine axis discovery
    NIH K99HL138193Apr 3, 2018 - Mar 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Decoding the complexities of lipid homeostasis through a unified mouse genetic resource. J Lipid Res. 2024 Jan 28; 65(4):100511. Viesi C, Seldin M. PMID: 38286180.
      View in: PubMed   Mentions:    Fields:    
    2. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. Elife. 2024 Jan 15; 12. Zhou M, Tamburini I, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo R, Bae H, Le J, Larson N, Pulido R, Nascimento-Filho CHV, Jang C, Marazzi I, Justice J, Pannunzio N, Hevener AL, Sparks L, Kershaw EE, Nicholas D, Parker BL, Masri S, Seldin MM. PMID: 38224289; PMCID: PMC10945578.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape. Front Endocrinol (Lausanne). 2023; 14:1279878. Garcia C, Velez LM, Ujagar N, Del Mundo Z, Nguyen T, Fox C, Mark A, Fisch KM, Lawson MA, Duleba AJ, Seldin MM, Nicholas DA. PMID: 38260148; PMCID: PMC10801245.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Induction of resistance to oxaliplatin in cancer by a microRNA/Fem1B/Gli1 pathway. Am J Cancer Res. 2023; 13(12):6011-6025. Su YC, Metzen LT, Vélez LM, Bournique E, Seldin M, Buisson R, Kuo WW, Huang CY, Kaiser P. PMID: 38187042; PMCID: PMC10767360.
      View in: PubMed   Mentions:
    5. Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation. Mol Cell. 2023 Dec 07; 83(23):4255-4271.e9. Torre D, Fstkchyan YS, Ho JSY, Cheon Y, Patel RS, Degrace EJ, Mzoughi S, Schwarz M, Mohammed K, Seo JS, Romero-Bueno R, Demircioglu D, Hasson D, Tang W, Mahajani SU, Campisi L, Zheng S, Song WS, Wang YC, Shah H, Francoeur N, Soto J, Salfati Z, Weirauch MT, Warburton P, Beaumont K, Smith ML, Mulder L, Villalta SA, Kessenbrock K, Jang C, Lee D, De Rubeis S, Cobos I, Tam O, Hammell MG, Seldin M, Shi Y, Basu U, Sebastiano V, Byun M, Sebra R, Rosenberg BR, Benner C, Guccione E, Marazzi I. PMID: 37995687; PMCID: PMC10842741.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Systems genetics approaches for understanding complex traits with relevance for human disease. Elife. 2023 11 14; 12. Allayee H, Farber CR, Seldin MM, Williams EG, James DE, Lusis AJ. PMID: 37962168; PMCID: PMC10645424.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Loss of CTRP10 results in female obesity with preserved metabolic health. bioRxiv. 2023 Nov 04. Chen F, Sarver DC, Saqib M, Velez LM, Aja S, Seldin MM, Wong GW. PMID: 37961647; PMCID: PMC10635050.
      View in: PubMed   Mentions:
    8. CTRP13 ablation improves systemic glucose and lipid metabolism. Mol Metab. 2023 Dec; 78:101824. Chen F, Sarver DC, Saqib M, Zhou M, Aja S, Seldin MM, Wong GW. PMID: 37844630; PMCID: PMC10598410.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. bioRxiv. 2023 Oct 04. Zhou M, Tamburini IJ, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo RX, Bae H, Le J, Larson N, Pulido R, Filho C, Jang C, Marazzi I, Justice JN, Pannunzio N, Hevener A, Sparks LM, Kershaw EE, Nicholas D, Parker B, Masri S, Seldin M. PMID: 37214953; PMCID: PMC10197628.
      View in: PubMed   Mentions:
    10. Feeding neurons integrate metabolic and reproductive states in mice. iScience. 2023 Oct 20; 26(10):107918. Massa MG, Scott RL, Cara AL, Cortes LR, Vander PB, Sandoval NP, Park JW, Ali SL, Velez LM, Wang HB, Ati SS, Tesfaye B, Reue K, van Veen JE, Seldin MM, Correa SM. PMID: 37817932; PMCID: PMC10561062.
      View in: PubMed   Mentions: 1  
    11. Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities. Res Sq. 2023 Sep 11. Pannunzio N, Rangel V, Sterrenberg J, Garawi A, Mezcord V, Folkerts M, Caulderon S, Wang J, Soyfer E, Eng O, Valerin J, Tanjasiri S, Quintero-Rivera F, Masri S, Seldin M, Frock R, Fleischman A. PMID: 37790327; PMCID: PMC10543404.
      View in: PubMed   Mentions:
    12. Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. Elife. 2023 06 05; 12. Chella Krishnan K, El Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gerdes Gyuricza I, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker B, James DE, Lusis AJ. PMID: 37276142; PMCID: PMC10241513.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice. Cell Rep. 2023 05 30; 42(5):112499. Moore TM, Lee S, Olsen T, Morselli M, Strumwasser AR, Lin AJ, Zhou Z, Abrishami A, Garcia SM, Bribiesca J, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQA, Anand ATS, Yackly A, Mendoza LQ, Leyva BK, Aliman C, Artiga DJ, Meng Y, Charugundla S, Pan C, Jedian V, Seldin MM, Ahn IS, Diamante G, Blencowe M, Yang X, Mouisel E, Pellegrini M, Turcotte LP, Birkeland KI, Norheim F, Drevon CA, Lusis AJ, Hevener AL. PMID: 37178122.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    14. Author Correction: Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nat Microbiol. 2023 Apr; 8(4):745. Zhang Q, Linke V, Overmyer KA, Traeger LL, Kasahara K, Miller IJ, Manson DE, Polaske TJ, Kerby RL, Kemis JH, Trujillo EA, Reddy TR, Russell JD, Schueler KL, Stapleton DS, Rabaglia ME, Seldin M, Gatti DM, Keele GR, Pham DT, Gerdt JP, Vivas EI, Lusis AJ, Keller MP, Churchill GA, Blackwell HE, Broman KW, Attie AD, Coon JJ, Rey FE. PMID: 36973420; PMCID: PMC10066032.
      View in: PubMed   Mentions:    Fields:    
    15. The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases. Elife. 2023 03 31; 12. Jurrjens AW, Seldin MM, Giles C, Meikle PJ, Drew BG, Calkin AC. PMID: 37000167; PMCID: PMC10065800.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    16. RNF130 Regulates LDLR Availability and Plasma LDL Cholesterol Levels. Circ Res. 2023 03 31; 132(7):849-863. Clifford BL, Jarrett KE, Cheng J, Cheng A, Seldin M, Morand P, Lee R, Chen M, Baldan A, de Aguiar Vallim TQ, Tarling EJ. PMID: 36876496; PMCID: PMC10065965.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    17. APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection. Nat Commun. 2023 02 14; 14(1):820. Manjunath L, Oh S, Ortega P, Bouin A, Bournique E, Sanchez A, Martensen PM, Auerbach AA, Becker JT, Seldin M, Harris RS, Semler BL, Buisson R. PMID: 36781883; PMCID: PMC9925369.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    18. Genetic mapping of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut. Nat Microbiol. 2023 03; 8(3):424-440. Zhang Q, Linke V, Overmyer KA, Traeger LL, Kasahara K, Miller IJ, Manson DE, Polaske TJ, Kerby RL, Kemis JH, Trujillo EA, Reddy TR, Russell JD, Schueler KL, Stapleton DS, Rabaglia ME, Seldin M, Gatti DM, Keele GR, Pham DT, Gerdt JP, Vivas EI, Lusis AJ, Keller MP, Churchill GA, Blackwell HE, Broman KW, Attie AD, Coon JJ, Rey FE. PMID: 36759753; PMCID: PMC9981464.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Feeding Neurons Integrate Metabolic and Reproductive States in Mice. bioRxiv. 2023 Jan 26. Massa MG, Scott RL, Cara AL, Cortes LR, Sandoval NP, Park JW, Ali S, Velez LM, Tesfaye B, Reue K, van Veen JE, Seldin M, Correa SM. PMID: 36747631; PMCID: PMC9900829.
      View in: PubMed   Mentions:
    20. Dysregulated systemic metabolism in a Down syndrome mouse model. Mol Metab. 2023 02; 68:101666. Sarver DC, Xu C, Velez LM, Aja S, Jaffe AE, Seldin MM, Reeves RH, Wong GW. PMID: 36587842; PMCID: PMC9841171.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    21. Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function. Elife. 2022 12 06; 11. Molendijk J, Blazev R, Mills RJ, Ng YK, Watt KI, Chau D, Gregorevic P, Crouch PJ, Hilton JBW, Lisowski L, Zhang P, Reue K, Lusis AJ, Hudson JE, James DE, Seldin MM, Parker BL. PMID: 36472367; PMCID: PMC9833826.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    22. Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure. Science. 2022 09 23; 377(6613):1399-1406. Cao Y, Wang Y, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H, Seldin MM, Lusis AJ. PMID: 36137043; PMCID: PMC9639660.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    23. Editorial: Crosstalk between adipose tissue and immune cells. Front Endocrinol (Lausanne). 2022; 13:1036737. Seldin MM, Shinoda K, Rajbhandari P. PMID: 36213298; PMCID: PMC9535362.
      View in: PubMed   Mentions:    Fields:    
    24. Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer. Sci Adv. 2022 08 12; 8(32):eabo2389. Chun SK, Fortin BM, Fellows RC, Habowski AN, Verlande A, Song WA, Mahieu AL, Lefebvre AEYT, Sterrenberg JN, Velez LM, Digman MA, Edwards RA, Pannunzio NR, Seldin MM, Waterman ML, Masri S. PMID: 35947664; PMCID: PMC9365282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    25. Author Correction: Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 Aug; 608(7924):E34. Campisi L, Chizari S, Ho JSY, Gromova A, Arnold FJ, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. PMID: 35945277.
      View in: PubMed   Mentions:    Fields:    
    26. Tryptophan metabolism is a physiological integrator regulating circadian rhythms. Mol Metab. 2022 10; 64:101556. Petrus P, Cervantes M, Samad M, Sato T, Chao A, Sato S, Koronowski KB, Park G, Alam Y, Mejhert N, Seldin MM, Monroy Kuhn JM, Dyar KA, Lutter D, Baldi P, Kaiser P, Jang C, Sassone-Corsi P. PMID: 35914650; PMCID: PMC9382333.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    27. Sex differences in heart mitochondria regulate diastolic dysfunction. Nat Commun. 2022 07 04; 13(1):3850. Cao Y, Vergnes L, Wang YC, Pan C, Chella Krishnan K, Moore TM, Rosa-Garrido M, Kimball TH, Zhou Z, Charugundla S, Rau CD, Seldin MM, Wang J, Wang Y, Vondriska TM, Reue K, Lusis AJ. PMID: 35787630; PMCID: PMC9253085.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 06; 606(7916):945-952. Campisi L, Chizari S, Ho JSY, Gromova A, Arnold FJ, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. PMID: 35732742; PMCID: PMC10089623.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    29. Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones. Elife. 2022 04 13; 11. Velez LM, Van C, Moore T, Zhou Z, Johnson C, Hevener AL, Seldin MM. PMID: 35416774; PMCID: PMC9094747.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    30. A mechanistic framework for cardiometabolic and coronary artery diseases. Nat Cardiovasc Res. 2022 Jan; 1(1):85-100. Koplev S, Seldin M, Sukhavasi K, Ermel R, Pang S, Zeng L, Bankier S, Di Narzo A, Cheng H, Meda V, Ma A, Talukdar H, Cohain A, Amadori L, Argmann C, Houten SM, Franzén O, Mocci G, Meelu OA, Ishikawa K, Whatling C, Jain A, Jain RK, Gan LM, Giannarelli C, Roussos P, Hao K, Schunkert H, Michoel T, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Björkegren JLM. PMID: 36276926; PMCID: PMC9583458.
      View in: PubMed   Mentions: 23  
    31. Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance. Cell Metab. 2022 02 01; 34(2):227-239.e6. Nelson ME, Madsen S, Cooke KC, Fritzen AM, Thorius IH, Masson SWC, Carroll L, Weiss FC, Seldin MM, Potter M, Hocking SL, Fazakerley DJ, Brandon AE, Thillainadesan S, Senior AM, Cooney GJ, Stöckli J, James DE. PMID: 35021042.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms. Sci Adv. 2021 Sep 24; 7(39):eabi7828. Greco CM, Koronowski KB, Smith JG, Shi J, Kunderfranco P, Carriero R, Chen S, Samad M, Welz PS, Zinna VM, Mortimer T, Chun SK, Shimaji K, Sato T, Petrus P, Kumar A, Vaca-Dempere M, Deryagin O, Van C, Kuhn JMM, Lutter D, Seldin MM, Masri S, Li W, Baldi P, Dyar KA, Muñoz-Cánoves P, Benitah SA, Sassone-Corsi P. PMID: 34550736; PMCID: PMC8457671.
      View in: PubMed   Mentions: 27     Fields:    
    33. Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1. JCI Insight. 2021 09 08; 6(17). Cao Y, Tang L, Du K, Paraiso K, Sun Q, Liu Z, Ye X, Fang Y, Yuan F, Chen H, Chen Y, Wang X, Yu C, Blitz IL, Wang PH, Huang L, Cheng H, Lu X, Cho KW, Seldin M, Fang Z, Yang Q. PMID: 34314389; PMCID: PMC8492328.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways. Nat Commun. 2021 08 13; 12(1):4917. Oh S, Bournique E, Bowen D, Jalili P, Sanchez A, Ward I, Dananberg A, Manjunath L, Tran GP, Semler BL, Maciejowski J, Seldin M, Buisson R. PMID: 34389714; PMCID: PMC8363607.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    35. NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice. Sci Rep. 2021 08 12; 11(1):16409. Guo F, Seldin M, Péterfy M, Charugundla S, Zhou Z, Lee SD, Mouton A, Rajbhandari P, Zhang W, Pellegrini M, Tontonoz P, Lusis AJ, Shih DM. PMID: 34385484; PMCID: PMC8361163.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    36. CoffeeProt: an online tool for correlation and functional enrichment of systems genetics data. Nucleic Acids Res. 2021 07 02; 49(W1):W104-W113. Molendijk J, Seldin MM, Parker BL. PMID: 33978718; PMCID: PMC8262721.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    37. Inflammation and reproductive function in women with polycystic ovary syndrome†. Biol Reprod. 2021 06 04; 104(6):1205-1217. Velez LM, Seldin M, Motta AB. PMID: 33739372; PMCID: PMC8785941.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    38. Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. Eur Heart J. 2021 03 01; 42(9):919-933. Hartiala JA, Han Y, Jia Q, Hilser JR, Huang P, Gukasyan J, Schwartzman WS, Cai Z, Biswas S, Trégouët DA, Smith NL, INVENT Consortium, CHARGE Consortium Hemostasis Working Group, GENIUS-CHD Consortium, Seldin M, Pan C, Mehrabian M, Lusis AJ, Bazeley P, Sun YV, Liu C, Quyyumi AA, Scholz M, Thiery J, Delgado GE, Kleber ME, März W, Howe LJ, Asselbergs FW, van Vugt M, Vlachojannis GJ, Patel RS, Lyytikäinen LP, Kähönen M, Lehtimäki T, Nieminen TVM, Kuukasjärvi P, Laurikka JO, Chang X, Heng CK, Jiang R, Kraus WE, Hauser ER, Ferguson JF, Reilly MP, Ito K, Koyama S, Kamatani Y, Komuro I, Biobank Japan, Stolze LK, Romanoski CE, Khan MD, Turner AW, Miller CL, Aherrahrou R, Civelek M, Ma L, Björkegren JLM, Kumar SR, Tang WHW, Hazen SL, Allayee H. PMID: 33532862; PMCID: PMC7936531.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    39. Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. 2021 05 04; 143(18):1809-1823. von Scheidt M, Zhao Y, de Aguiar Vallim TQ, Che N, Wierer M, Seldin MM, Franzén O, Kurt Z, Pang S, Bongiovanni D, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic JC, Mann M, Björkegren JLM, Lusis AJ, Yang X, Schunkert H. PMID: 33626882; PMCID: PMC8124091.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    40. Genetic regulation of liver lipids in a mouse model of insulin resistance and hepatic steatosis. Mol Syst Biol. 2021 01; 17(1):e9684. Norheim F, Chella Krishnan K, Bjellaas T, Vergnes L, Pan C, Parks BW, Meng Y, Lang J, Ward JA, Reue K, Mehrabian M, Gundersen TE, Péterfy M, Dalen KT, Drevon CA, Hui ST, Lusis AJ, Seldin MM. PMID: 33417276; PMCID: PMC7792507.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    41. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling. Sci Transl Med. 2020 08 05; 12(555). Zhou Z, Moore TM, Drew BG, Ribas V, Wanagat J, Civelek M, Segawa M, Wolf DM, Norheim F, Seldin MM, Strumwasser AR, Whitney KA, Lester E, Reddish BR, Vergnes L, Reue K, Rajbhandari P, Tontonoz P, Lee J, Mahata SK, Hewitt SC, Shirihai O, Gastonbury C, Small KS, Laakso M, Jensen J, Lee S, Drevon CA, Korach KS, Lusis AJ, Hevener AL. PMID: 32759275; PMCID: PMC8212422.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    42. Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury. Cell. 2020 08 06; 182(3):545-562.e23. Yokota T, McCourt J, Ma F, Ren S, Li S, Kim TH, Kurmangaliyev YZ, Nasiri R, Ahadian S, Nguyen T, Tan XHM, Zhou Y, Wu R, Rodriguez A, Cohn W, Wang Y, Whitelegge J, Ryazantsev S, Khademhosseini A, Teitell MA, Chiou PY, Birk DE, Rowat AC, Crosbie RH, Pellegrini M, Seldin M, Lusis AJ, Deb A. PMID: 32621799; PMCID: PMC7415659.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    43. FAM13A affects body fat distribution and adipocyte function. Nat Commun. 2020 03 19; 11(1):1465. Fathzadeh M, Li J, Rao A, Cook N, Chennamsetty I, Seldin M, Zhou X, Sangwung P, Gloudemans MJ, Keller M, Attie A, Yang J, Wabitsch M, Carcamo-Orive I, Tada Y, Lusis AJ, Shin MK, Molony CM, McLaughlin T, Reaven G, Montgomery SB, Reilly D, Quertermous T, Ingelsson E, Knowles JW. PMID: 32193374; PMCID: PMC7081215.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    44. Systems genetics applications in metabolism research. Nat Metab. 2019 11; 1(11):1038-1050. Seldin M, Yang X, Lusis AJ. PMID: 32259026; PMCID: PMC7111511.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    45. Sex-specific metabolic functions of adipose Lipocalin-2. Mol Metab. 2019 12; 30:30-47. Chella Krishnan K, Sabir S, Shum M, Meng Y, Acín-Pérez R, Lang JM, Floyd RR, Vergnes L, Seldin MM, Fuqua BK, Jayasekera DW, Nand SK, Anum DC, Pan C, Stiles L, Péterfy M, Reue K, Liesa M, Lusis AJ. PMID: 31767179; PMCID: PMC6812340.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    46. Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism. Mol Metab. 2019 06; 24:44-63. Geoghegan G, Simcox J, Seldin MM, Parnell TJ, Stubben C, Just S, Begaye L, Lusis AJ, Villanueva CJ. PMID: 30948248; PMCID: PMC6531814.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    47. An integrative systems genetic analysis of mammalian lipid metabolism. Nature. 2019 03; 567(7747):187-193. Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. PMID: 30814737; PMCID: PMC6656374.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    48. Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits. Cell Metab. 2019 04 02; 29(4):932-949.e4. Norheim F, Hasin-Brumshtein Y, Vergnes L, Chella Krishnan K, Pan C, Seldin MM, Hui ST, Mehrabian M, Zhou Z, Gupta S, Parks BW, Walch A, Reue K, Hofmann SM, Arnold AP, Lusis AJ. PMID: 30639359; PMCID: PMC6447452.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    49. Systems-based approaches for investigation of inter-tissue communication. J Lipid Res. 2019 03; 60(3):450-455. Seldin MM, Lusis AJ. PMID: 30617149; PMCID: PMC6399495.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    50. The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle. Mol Metab. 2019 03; 21:51-67. Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL. PMID: 30591411; PMCID: PMC6407367.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    51. Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans. G3 (Bethesda). 2018 11 06; 8(11):3499-3506. Lin LY, Chun Chang S, O'Hearn J, Hui ST, Seldin M, Gupta P, Bondar G, Deng M, Jauhiainen R, Kuusisto J, Laakso M, Sinsheimer JS, Deb A, Rau C, Ren S, Wang Y, Lusis AJ, Wang JJ, Huertas-Vazquez A. PMID: 30201759; PMCID: PMC6222577.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    52. Transcription Factor Zhx2 Deficiency Reduces Atherosclerosis and Promotes Macrophage Apoptosis in Mice. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):2016-2027. Erbilgin A, Seldin MM, Wu X, Mehrabian M, Zhou Z, Qi H, Dabirian KS, Sevag Packard RR, Hsieh W, Bensinger SJ, Sinha S, Lusis AJ. PMID: 30026271; PMCID: PMC6202168.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    53. Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet. 2018 07 15; 27(14):2586. Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis AJ, Pellegrini M. PMID: 29893869; PMCID: PMC6030960.
      View in: PubMed   Mentions: 9     Fields:    
    54. Epigenome-wide association in adipose tissue from the METSIM cohort. Hum Mol Genet. 2018 05 15; 27(10):1830-1846. Orozco LD, Farrell C, Hale C, Rubbi L, Rinaldi A, Civelek M, Pan C, Lam L, Montoya D, Edillor C, Seldin M, Boehnke M, Mohlke KL, Jacobsen S, Kuusisto J, Laakso M, Lusis AJ, Pellegrini M. PMID: 29566149; PMCID: PMC5932563.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    55. A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism. Cell Metab. 2018 May 01; 27(5):1138-1155.e6. Seldin MM, Koplev S, Rajbhandari P, Vergnes L, Rosenberg GM, Meng Y, Pan C, Phuong TMN, Gharakhanian R, Che N, Mäkinen S, Shih DM, Civelek M, Parks BW, Kim ED, Norheim F, Chella Krishnan K, Hasin-Brumshtein Y, Mehrabian M, Laakso M, Drevon CA, Koistinen HA, Tontonoz P, Reue K, Cantor RM, Björkegren JLM, Lusis AJ. PMID: 29719227; PMCID: PMC5935137.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    56. Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circ Res. 2018 06 22; 123(1):73-85. Yu J, Seldin MM, Fu K, Li S, Lam L, Wang P, Wang Y, Huang D, Nguyen TL, Wei B, Kulkarni RP, Di Carlo D, Teitell M, Pellegrini M, Lusis AJ, Deb A. PMID: 29691232; PMCID: PMC6014922.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    57. Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease. Cell Syst. 2018 Jan 24; 6(1):103-115.e7. Chella Krishnan K, Kurt Z, Barrere-Cain R, Sabir S, Das A, Floyd R, Vergnes L, Zhao Y, Che N, Charugundla S, Qi H, Zhou Z, Meng Y, Pan C, Seldin MM, Norheim F, Hui S, Reue K, Lusis AJ, Yang X. PMID: 29361464; PMCID: PMC5799036.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    58. IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure. Cell. 2018 01 11; 172(1-2):218-233.e17. Rajbhandari P, Thomas BJ, Feng AC, Hong C, Wang J, Vergnes L, Sallam T, Wang B, Sandhu J, Seldin MM, Lusis AJ, Fong LG, Katz M, Lee R, Young SG, Reue K, Smale ST, Tontonoz P. PMID: 29249357; PMCID: PMC5766418.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    59. C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. J Biol Chem. 2017 09 08; 292(36):14836-14850. Lei X, Seldin MM, Little HC, Choy N, Klonisch T, Wong GW. PMID: 28726640; PMCID: PMC5592665.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    60. Multi-omics approaches to disease. Genome Biol. 2017 05 05; 18(1):83. Hasin Y, Seldin M, Lusis A. PMID: 28476144; PMCID: PMC5418815.
      View in: PubMed   Mentions: 723     Fields:    Translation:Humans
    61. A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H728-H741. Seldin MM, Kim ED, Romay MC, Li S, Rau CD, Wang JJ, Krishnan KC, Wang Y, Deb A, Lusis AJ. PMID: 28235788; PMCID: PMC5407157.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    62. Mice lacking sialyltransferase ST3Gal-II develop late-onset obesity and insulin resistance. Glycobiology. 2017 01; 27(2):129-139. Lopez PH, Aja S, Aoki K, Seldin MM, Lei X, Ronnett GV, Wong GW, Schnaar RL. PMID: 27683310; PMCID: PMC5224593.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    63. Loss of CTRP5 improves insulin action and hepatic steatosis. Am J Physiol Endocrinol Metab. 2016 06 01; 310(11):E1036-52. Lei X, Rodriguez S, Petersen PS, Seldin MM, Bowman CE, Wolfgang MJ, Wong GW. PMID: 27143553; PMCID: PMC4935138.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    64. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 06; 57(6):925-42. Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. PMID: 27099397; PMCID: PMC4878195.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    65. Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. J Am Heart Assoc. 2016 Feb 22; 5(2). Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. PMID: 26903003; PMCID: PMC4802459.
      View in: PubMed   Mentions: 335     Fields:    Translation:HumansAnimalsCells
    66. Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain. ASN Neuro. 2015 Sep-Oct; 7(5). Hubbard JA, Hsu MS, Seldin MM, Binder DK. PMID: 26489685; PMCID: PMC4623559.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    67. Dynamic Visualization of mTORC1 Activity in Living Cells. Cell Rep. 2015 Mar 17; 10(10):1767-1777. Zhou X, Clister TL, Lowry PR, Seldin MM, Wong GW, Zhang J. PMID: 25772363; PMCID: PMC4567530.
      View in: PubMed   Mentions: 67     Fields:    
    68. Thromboxane synthase deficiency improves insulin action and attenuates adipose tissue fibrosis. Am J Physiol Endocrinol Metab. 2015 May 01; 308(9):E792-804. Lei X, Li Q, Rodriguez S, Tan SY, Seldin MM, McLenithan JC, Jia W, Wong GW. PMID: 25738781; PMCID: PMC4420899.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    69. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metab. 2015 Jan 06; 21(1):138-49. Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, Feinberg AP. PMID: 25565211; PMCID: PMC4340475.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    70. Dynamic and extensive metabolic state-dependent regulation of cytokine expression and circulating levels. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15; 307(12):R1458-70. Petersen PS, Lei X, Seldin MM, Rodriguez S, Byerly MS, Wolfe A, Whitlock S, Wong GW. PMID: 25320344; PMCID: PMC4269668.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    71. Seasonal oscillation of liver-derived hibernation protein complex in the central nervous system of non-hibernating mammals. J Exp Biol. 2014 Aug 01; 217(Pt 15):2667-79. Seldin MM, Byerly MS, Petersen PS, Swanson R, Balkema-Buschmann A, Groschup MH, Wong GW. PMID: 25079892; PMCID: PMC4117459.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    72. Metabolic function of the CTRP family of hormones. Rev Endocr Metab Disord. 2014 Jun; 15(2):111-23. Seldin MM, Tan SY, Wong GW. PMID: 23963681; PMCID: PMC3931758.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansCells
    73. CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice. PLoS One. 2014; 9(2):e88535. Peterson JM, Seldin MM, Tan SY, Wong GW. PMID: 24586339; PMCID: PMC3930646.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    74. C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. J Biol Chem. 2014 Feb 14; 289(7):4055-69. Byerly MS, Petersen PS, Ramamurthy S, Seldin MM, Lei X, Provost E, Wei Z, Ronnett GV, Wong GW. PMID: 24366864; PMCID: PMC3924272.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    75. Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013 Dec 13; 288(50):36073-82. Seldin MM, Lei X, Tan SY, Stanson KP, Wei Z, Wong GW. PMID: 24187137; PMCID: PMC3861655.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    76. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol. 2013 Sep; 305(5):R522-33. Peterson JM, Wei Z, Seldin MM, Byerly MS, Aja S, Wong GW. PMID: 23842676; PMCID: PMC3763026.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    77. CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 01; 305(3):G214-24. Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW. PMID: 23744740; PMCID: PMC3742855.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    78. A central role for C1q/TNF-related protein 13 (CTRP13) in modulating food intake and body weight. PLoS One. 2013; 8(4):e62862. Byerly MS, Swanson R, Wei Z, Seldin MM, McCulloh PS, Wong GW. PMID: 23638159; PMCID: PMC3636217.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    79. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. J Biol Chem. 2013 Apr 12; 288(15):10214-29. Wei Z, Seldin MM, Natarajan N, Djemal DC, Peterson JM, Wong GW. PMID: 23449976; PMCID: PMC3624406.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    80. Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. Adipocyte. 2012 Oct 01; 1(4):200-202. Seldin MM, Wong GW. PMID: 23700534; PMCID: PMC3609113.
      View in: PubMed   Mentions: 25     Fields:    
    81. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. J Biol Chem. 2012 Oct 19; 287(43):35804-14. Wei Z, Lei X, Seldin MM, Wong GW. PMID: 22942287; PMCID: PMC3476250.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    82. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012 Apr 06; 287(15):11968-80. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. PMID: 22351773; PMCID: PMC3320944.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansAnimalsCells
    83. Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis. Exp Neurol. 2012 May; 235(1):246-55. Lee DJ, Hsu MS, Seldin MM, Arellano JL, Binder DK. PMID: 22361023; PMCID: PMC3334411.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    84. Aquaporin-4-dependent edema clearance following status epilepticus. Epilepsy Res. 2012 Feb; 98(2-3):264-8. Lee DJ, Amini M, Hamamura MJ, Hsu MS, Seldin MM, Nalcioglu O, Binder DK. PMID: 21996149.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    85. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Ann Neurol. 2010 Jun; 67(6):794-801. Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. PMID: 20517941.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
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