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Michelle Digman

Title(s)Assistant Professor, Biomedical Engineering
Phone(949) 824-3255
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sameni S, Zhang R, Digman MA. Number and molecular brightness analysis reveals Htt25Q protein aggregation upon the uptake of Htt97Q aggregates. Biochem Biophys Res Commun. 2019 Nov 19. PMID: 31757420.
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    2. Ma N, Mochel NR, Pham PD, Yoo TY, Cho KWY, Digman MA. Label-free assessment of pre-implantation embryo quality by the Fluorescence Lifetime Imaging Microscopy (FLIM)-phasor approach. Sci Rep. 2019 Sep 13; 9(1):13206. PMID: 31519916.
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    3. Trivedi P, Palomba F, Niedzialkowska E, Digman MA, Gratton E, Stukenberg PT. The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. Nat Cell Biol. 2019 09; 21(9):1127-1137. PMID: 31481798.
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    4. Murata MM, Kong X, Moncada E, Chen Y, Imamura H, Wang P, Berns MW, Yokomori K, Digman MA. NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival. Mol Biol Cell. 2019 Sep 15; 30(20):2584-2597. PMID: 31390283.
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    5. Dong Y, Sameni S, Digman MA, Brewer GJ. Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts. Sci Rep. 2019 Aug 02; 9(1):11274. PMID: 31375701.
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    6. Planes N, Digman MA, Vanderheyden PPML, Gratton E, Caballero-George C. Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding. Biochim Biophys Acta Gen Subj. 2019 May; 1863(5):917-924. PMID: 30851407.
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    7. Chen H, Ma N, Kagawa K, Kawahito S, Digman M, Gratton E. Widefield multifrequency fluorescence lifetime imaging using a two-tap complementary metal-oxide semiconductor camera with lateral electric field charge modulators. J Biophotonics. 2019 May; 12(5):e201800223. PMID: 30421535.
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    8. Dong Y, Digman MA, Brewer GJ. Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy. Geroscience. 2019 02; 41(1):51-67. PMID: 30729413.
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    9. Ma N, Kamalakshakurup G, Aghaamoo M, Lee AP, Digman MA. Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy. Cytometry A. 2019 01; 95(1):93-100. PMID: 30536717.
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    10. Mah EJ, Lefebvre AEYT, McGahey GE, Yee AF, Digman MA. Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility. Sci Rep. 2018 11 20; 8(1):17094. PMID: 30459440.
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    11. Anzalone A, Chacko JV, Nishi RA, Dumont C, Smith D, Shea LD, Digman MA, Cummings BJ, Anderson AJ. Feasibility study on mouse live imaging after spinal cord injury and poly(lactide-co-glycolide) bridge implantation. J Biomed Opt. 2018 06; 23(6):1-6. PMID: 29959835.
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    12. Lee DH, Li X, Ma N, Digman MA, Lee AP. Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy. Lab Chip. 2018 05 01; 18(9):1349-1358. PMID: 29638231.
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    13. Sameni S, Malacrida L, Tan Z, Digman MA. Publisher Correction: Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Sci Rep. 2018 Apr 11; 8(1):6060. PMID: 29643420.
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    14. Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL. PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov. 2018 07; 8(7):866-883. PMID: 29572236.
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    15. Mäntylä E, Chacko JV, Aho V, Parrish CR, Shahin V, Kann M, Digman MA, Gratton E, Vihinen-Ranta M. Viral highway to nucleus exposed by image correlation analyses. Sci Rep. 2018 01 18; 8(1):1152. PMID: 29348472.
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    16. Sameni S, Malacrida L, Tan Z, Digman MA. Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Sci Rep. 2018 01 15; 8(1):734. PMID: 29335600.
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    17. Kong L, Murata MM, Digman MA. Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells. Biochem Biophys Res Commun. 2018 01 29; 496(1):199-204. PMID: 29307819.
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    18. Davey RJ, Digman MA, Gratton E, Moens PDJ. Quantitative image mean squared displacement (iMSD) analysis of the dynamics of profilin 1 at the membrane of live cells. Methods. 2018 05 01; 140-141:119-125. PMID: 29242135.
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    19. Trinh AL, Chen H, Chen Y, Hu Y, Li Z, Siegel ER, Linskey ME, Wang PH, Digman MA, Zhou YH. Tracking Functional Tumor Cell Subpopulations of Malignant Glioma by Phasor Fluorescence Lifetime Imaging Microscopy of NADH. Cancers (Basel). 2017 Dec 06; 9(12). PMID: 29211022.
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    20. Digiacomo L, Cardarelli F, Pozzi D, Palchetti S, Digman MA, Gratton E, Capriotti AL, Mahmoudi M, Caracciolo G. An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles. Nanoscale. 2017 Nov 16; 9(44):17254-17262. PMID: 29115333.
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    21. Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W. Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 07 26; 9(400). PMID: 28747514.
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    22. Herrington KA, Trinh AL, Dang C, O'Shaughnessy E, Hahn KM, Gratton E, Digman MA, Sütterlin C. Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation. Mol Biol Cell. 2017 Jul 15; 28(15):2135-2145. PMID: 28539409.
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    23. Liang EI, Mah EJ, Yee AF, Digman MA. Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography. Integr Biol (Camb). 2017 02 20; 9(2):145-155. PMID: 28092391.
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    24. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. PMID: 27914984.
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    25. Sameni S, Syed A, Marsh JL, Digman MA. The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease. Sci Rep. 2016 10 07; 6:34755. PMID: 27713486.
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    26. Cinco R, Digman MA, Gratton E, Luderer U. Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary. Biol Reprod. 2016 12; 95(6):129. PMID: 27683265.
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    27. Chen H, Gratton E, Digman MA. Self-assisted optothermal trapping of gold nanorods under two-photon excitation. Methods Appl Fluoresc. 2016 09 06; 4(3):035003. PMID: 28355163.
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    28. Qiu Y, Lin CY, Hinkle P, Plett TS, Yang C, Chacko JV, Digman MA, Yeh LH, Hsu JP, Siwy ZS. Highly Charged Particles Cause a Larger Current Blockage in Micropores Compared to Neutral Particles. ACS Nano. 2016 09 27; 10(9):8413-22. PMID: 27532683.
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    29. Digiacomo L, Digman MA, Gratton E, Caracciolo G. Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles. Acta Biomater. 2016 09 15; 42:189-198. PMID: 27449340.
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    30. Chen CC, Liu L, Ma F, Wong CW, Guo XE, Chacko JV, Farhoodi HP, Zhang SX, Zimak J, Ségaliny A, Riazifar M, Pham V, Digman MA, Pone EJ, Zhao W. Elucidation of Exosome Migration across the Blood-Brain Barrier Model In Vitro. Cell Mol Bioeng. 2016 Dec; 9(4):509-529. PMID: 28392840.
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    31. Ma N, Digman MA, Malacrida L, Gratton E. Measurements of absolute concentrations of NADH in cells using the phasor FLIM method. Biomed Opt Express. 2016 Jul 01; 7(7):2441-52. PMID: 27446681.
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    32. Sosnik J, Zheng L, Rackauckas CV, Digman M, Gratton E, Nie Q, Schilling TF. Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. Elife. 2016 Apr 12; 5:e14034. PMID: 27067377.
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    33. Zhang K, Kang DK, Ali MM, Liu L, Labanieh L, Lu M, Riazifar H, Nguyen TN, Zell JA, Digman MA, Gratton E, Li J, Zhao W. Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection. Lab Chip. 2015 Nov 07; 15(21):4217-26. PMID: 26387763.
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    34. Mieruszynski S, Digman MA, Gratton E, Jones MR. Characterization of exogenous DNA mobility in live cells through fluctuation correlation spectroscopy. Sci Rep. 2015 Sep 10; 5:13848. PMID: 26354725.
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    35. Hendrix J, Baumgärtel V, Schrimpf W, Ivanchenko S, Digman MA, Gratton E, Kräusslich HG, Müller B, Lamb DC. Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers. J Cell Biol. 2015 Aug 17; 210(4):629-46. PMID: 26283800.
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    36. Adu-Gyamfi E, Johnson KA, Fraser ME, Scott JL, Soni SP, Jones KR, Digman MA, Gratton E, Tessier CR, Stahelin RV. Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus. J Virol. 2015 Sep; 89(18):9440-53. PMID: 26136573.
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    37. Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Mol Psychiatry. 2015 Nov; 20(11):1286-93. PMID: 26100538.
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    38. Mieruszynski S, Briggs C, Digman MA, Gratton E, Jones MR. Live Cell Characterization of DNA Aggregation Delivered through Lipofection. Sci Rep. 2015 May 27; 5:10528. PMID: 26013547.
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    39. Olivera-Couto A, Salzman V, Mailhos M, Digman MA, Gratton E, Aguilar PS. Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium. Biophys J. 2015 Apr 07; 108(7):1633-1644. PMID: 25863055.
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    40. Moens PDJ, Digman MA, Gratton E. Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis. Biophys J. 2015 Mar 24; 108(6):1448-1458. PMID: 25809257.
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    41. Chen H, Gratton E, Digman MA. Spectral properties and dynamics of gold nanorods revealed by EMCCD-based spectral phasor method. Microsc Res Tech. 2015 Apr; 78(4):283-93. PMID: 25684346.
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    42. Kang DK, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun. 2014 Nov 13; 5:5427. PMID: 25391809.
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    43. Adu-Gyamfi E, Soni SP, Jee CS, Digman MA, Gratton E, Stahelin RV. A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress. Viruses. 2014 Oct 17; 6(10):3837-54. PMID: 25330123.
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    44. Chiu CL, Aguilar JS, Tsai CY, Wu G, Gratton E, Digman MA. Nanoimaging of focal adhesion dynamics in 3D. PLoS One. 2014; 9(6):e99896. PMID: 24959851.
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    45. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. PMID: 24825347.
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    46. Sharma H, Digman MA, Felsinger N, Gratton E, Khine M. Enhanced emission of fluorophores on shrink-induced wrinkled composite structures. Opt Mater Express. 2014; 4(4):753-763. PMID: 25383253.
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    47. Pozzi D, Marchini C, Cardarelli F, Salomone F, Coppola S, Montani M, Zabaleta ME, Digman MA, Gratton E, Colapicchioni V, Caracciolo G. Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: interplay between nanostructure and composition. Biochim Biophys Acta. 2014 Mar; 1838(3):957-67. PMID: 24296066.
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    48. Chiu CL, Digman MA, Gratton E. Measuring actin flow in 3D cell protrusions. Biophys J. 2013 Oct 15; 105(8):1746-55. PMID: 24138850.
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    49. James NG, Digman MA, Ross JA, Barylko B, Wang L, Li J, Chen Y, Mueller JD, Gratton E, Albanesi JP, Jameson DM. A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells. Biochim Biophys Acta. 2014 Jan; 1840(1):315-21. PMID: 24016602.
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    50. Chiu CL, Digman MA, Gratton E. Cell matrix remodeling ability shown by image spatial correlation. J Biophys. 2013; 2013:532030. PMID: 23935614.
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    51. Andrews LM, Jones MR, Digman MA, Gratton E. Detecting Pyronin Y labeled RNA transcripts in live cell microenvironments by phasor-FLIM analysis. Methods Appl Fluoresc. 2013 Mar 01; 1(1):015001. PMID: 24563776.
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    52. Coppola S, Cardarelli F, Pozzi D, Estrada LC, Digman MA, Gratton E, Bifone A, Marianecci C, Caracciolo G. The role of cytoskeleton networks on lipid-mediated delivery of DNA. Ther Deliv. 2013 Feb; 4(2):191-202. PMID: 23343159.
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    53. Adu-Gyamfi E, Soni SP, Xue Y, Digman MA, Gratton E, Stahelin RV. The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress. J Biol Chem. 2013 Feb 22; 288(8):5779-89. PMID: 23297401.
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    54. Digman MA, Stakic M, Gratton E. Raster image correlation spectroscopy and number and brightness analysis. Methods Enzymol. 2013; 518:121-44. PMID: 23276538.
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    55. Coppola S, Pozzi D, De Sanctis SC, Digman MA, Gratton E, Caracciolo G. Quantitative measurement of intracellular transport of nanocarriers by spatio-temporal image correlation spectroscopy. Methods Appl Fluoresc. 2013; 1(1). PMID: 24376913.
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    56. Andrews LM, Jones MR, Digman MA, Gratton E. Spectral phasor analysis of Pyronin Y labeled RNA microenvironments in living cells. Biomed Opt Express. 2013 Jan 01; 4(1):171-7. PMID: 23304656.
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    57. Hinde E, Digman MA, Hahn KM, Gratton E. Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):135-40. PMID: 23248275.
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    58. Torno K, Wright BK, Jones MR, Digman MA, Gratton E, Phillips M. Real-time analysis of metabolic activity within Lactobacillus acidophilus by phasor fluorescence lifetime imaging microscopy of NADH. Curr Microbiol. 2013 Apr; 66(4):365-7. PMID: 23233088.
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    59. Whiteside MD, Digman MA, Gratton E, Treseder KK. Organic nitrogen uptake by arbuscular mycorrhizal fungi in a boreal forest. Soil Biol Biochem. 2012 Dec; 55. PMID: 24371363.
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    60. Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein. Biophys J. 2012 Nov 07; 103(9):L41-3. PMID: 23199932.
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    61. Wright BK, Andrews LM, Jones MR, Stringari C, Digman MA, Gratton E. Phasor-FLIM analysis of NADH distribution and localization in the nucleus of live progenitor myoblast cells. Microsc Res Tech. 2012 Dec; 75(12):1717-22. PMID: 23019116.
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    62. Coppola S, Estrada LC, Digman MA, Pozzi D, Cardarelli F, Gratton E, Caracciolo G. Intracellular trafficking of cationic liposome-DNA complexes in living cells. Soft Matter. 2012 Aug 14; 8(30):7919-7927. PMID: 25152766.
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    63. Wright BK, Andrews LM, Markham J, Jones MR, Stringari C, Digman MA, Gratton E. NADH distribution in live progenitor stem cells by phasor-fluorescence lifetime image microscopy. Biophys J. 2012 Jul 03; 103(1):L7-9. PMID: 22828352.
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    64. James NG, Digman MA, Gratton E, Barylko B, Ding X, Albanesi JP, Goldberg MS, Jameson DM. Number and brightness analysis of LRRK2 oligomerization in live cells. Biophys J. 2012 Jun 06; 102(11):L41-3. PMID: 22713584.
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    65. Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis. Biophys J. 2012 Jun 06; 102(11):2517-25. PMID: 22713567.
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    66. Battisti A, Digman MA, Gratton E, Storti B, Beltram F, Bizzarri R. Intracellular pH measurements made simple by fluorescent protein probes and the phasor approach to fluorescence lifetime imaging. Chem Commun (Camb). 2012 May 25; 48(42):5127-9. PMID: 22517076.
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    67. Zhou S, Lo WC, Suhalim JL, Digman MA, Gratton E, Nie Q, Lander AD. Free extracellular diffusion creates the Dpp morphogen gradient of the Drosophila wing disc. Curr Biol. 2012 Apr 24; 22(8):668-75. PMID: 22445299.
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    68. Digman MA, Gratton E. Scanning image correlation spectroscopy. Bioessays. 2012 May; 34(5):377-85. PMID: 22415853.
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    69. Hinde E, Cardarelli F, Digman MA, Gratton E. Changes in chromatin compaction during the cell cycle revealed by micrometer-scale measurement of molecular flow in the nucleus. Biophys J. 2012 Feb 08; 102(3):691-7. PMID: 22325293.
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    70. Kniazeva E, Weidling JW, Singh R, Botvinick EL, Digman MA, Gratton E, Putnam AJ. Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D. Integr Biol (Camb). 2012 Apr; 4(4):431-9. PMID: 22281872.
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    71. Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure. 2011 Dec 07; 19(12):1826-36. PMID: 22153505.
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    72. Hinde E, Digman MA, Welch C, Hahn KM, Gratton E. Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microsc Res Tech. 2012 Mar; 75(3):271-81. PMID: 21858900.
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    73. Stringari C, Cinquin A, Cinquin O, Digman MA, Donovan PJ, Gratton E. Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13582-7. PMID: 21808026.
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    74. Caracciolo G, Pozzi D, Capriotti AL, Marianecci C, Carafa M, Marchini C, Montani M, Amici A, Amenitsch H, Digman MA, Gratton E, Sanchez SS, Laganà A. Factors determining the superior performance of lipid/DNA/protammine nanoparticles over lipoplexes. J Med Chem. 2011 Jun 23; 54(12):4160-71. PMID: 21615134.
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    75. Hinde E, Cardarelli F, Digman MA, Kershner A, Kimble J, Gratton E. The impact of mitotic versus interphase chromatin architecture on the molecular flow of EGFP by pair correlation analysis. Biophys J. 2011 Apr 06; 100(7):1829-36. PMID: 21463597.
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    76. Lanzano L, Digman MA, Fwu P, Giral H, Levi M, Gratton E. Nanometer-scale imaging by the modulation tracking method. J Biophotonics. 2011 Jun; 4(6):415-24. PMID: 21462350.
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    77. Marchini C, Pozzi D, Montani M, Alfonsi C, Amici A, Candeloro De Sanctis S, Digman MA, Sanchez S, Gratton E, Amenitsch H, Fabbretti A, Gualerzi CO, Caracciolo G. Role of temperature-independent lipoplex-cell membrane interactions in the efficiency boost of multicomponent lipoplexes. Cancer Gene Ther. 2011 Aug; 18(8):543-52. PMID: 21394110.
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    78. Vetri V, Ossato G, Militello V, Digman MA, Leone M, Gratton E. Fluctuation methods to study protein aggregation in live cells: concanavalin A oligomers formation. Biophys J. 2011 Feb 02; 100(3):774-783. PMID: 21281593.
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    79. Ross JA, Digman MA, Wang L, Gratton E, Albanesi JP, Jameson DM. Oligomerization state of dynamin 2 in cell membranes using TIRF and number and brightness analysis. Biophys J. 2011 Feb 02; 100(3):L15-L17. PMID: 21281565.
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    80. Choi CK, Zareno J, Digman MA, Gratton E, Horwitz AR. Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions. Biophys J. 2011 Feb 02; 100(3):583-592. PMID: 21281572.
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    81. Digman MA, Gratton E. Lessons in fluctuation correlation spectroscopy. Annu Rev Phys Chem. 2011; 62:645-68. PMID: 21219151.
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    82. Kim SA, Sanabria H, Digman MA, Gratton E, Schwille P, Zipfel WR, Waxham MN. Quantifying translational mobility in neurons: comparison between current optical techniques. J Neurosci. 2010 Dec 08; 30(49):16409-16. PMID: 21147979.
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    83. Rossow MJ, Sasaki JM, Digman MA, Gratton E. Raster image correlation spectroscopy in live cells. Nat Protoc. 2010 Nov; 5(11):1761-74. PMID: 21030952.
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    84. Presman DM, Alvarez LD, Levi V, Eduardo S, Digman MA, Martí MA, Veleiro AS, Burton G, Pecci A. Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids. PLoS One. 2010 Oct 11; 5(10):e13279. PMID: 20949009.
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    85. Kuo WJ, Digman MA, Lander AD. Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization. Mol Biol Cell. 2010 Nov 15; 21(22):4028-41. PMID: 20861306.
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    86. Hinde E, Cardarelli F, Digman MA, Gratton E. In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependent molecular flow. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16560-5. PMID: 20823232.
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    87. Ossato G, Digman MA, Aiken C, Lukacsovich T, Marsh JL, Gratton E. A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis. Biophys J. 2010 Jun 16; 98(12):3078-85. PMID: 20550921.
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    88. Yoon Y, Tong J, Lee PJ, Albanese A, Bhardwaj N, Källberg M, Digman MA, Lu H, Gratton E, Shin YK, Cho W. Molecular basis of the potent membrane-remodeling activity of the epsin 1 N-terminal homology domain. J Biol Chem. 2010 Jan 01; 285(1):531-40. PMID: 19880963.
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    89. Digman MA, Gratton E. Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct; 1(2):273-282. PMID: 20835996.
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    90. Digman MA, Gratton E. Imaging barriers to diffusion by pair correlation functions. Biophys J. 2009 Jul 22; 97(2):665-73. PMID: 19619481.
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    91. Gielen E, Smisdom N, vandeVen M, De Clercq B, Gratton E, Digman M, Rigo JM, Hofkens J, Engelborghs Y, Ameloot M. Measuring diffusion of lipid-like probes in artificial and natural membranes by raster image correlation spectroscopy (RICS): use of a commercial laser-scanning microscope with analog detection. Langmuir. 2009 May 05; 25(9):5209-18. PMID: 19260653.
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    92. Caracciolo G, Caminiti R, Digman MA, Gratton E, Sanchez S. Efficient escape from endosomes determines the superior efficiency of multicomponent lipoplexes. J Phys Chem B. 2009 Apr 16; 113(15):4995-7. PMID: 19301832.
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    93. Digman MA, Gratton E. Analysis of diffusion and binding in cells using the RICS approach. Microsc Res Tech. 2009 Apr; 72(4):323-32. PMID: 19067357.
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    94. Gratton E, Digman M. One photon up, one photon down. Nat Biotechnol. 2009 Feb; 27(2):147-8. PMID: 19204693.
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    95. Digman MA, Wiseman PW, Choi C, Horwitz AR, Gratton E. Stoichiometry of molecular complexes at adhesions in living cells. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2170-5. PMID: 19168634.
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    96. Digman MA, Wiseman PW, Horwitz AR, Gratton E. Detecting protein complexes in living cells from laser scanning confocal image sequences by the cross correlation raster image spectroscopy method. Biophys J. 2009 Jan; 96(2):707-16. PMID: 19167315.
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    97. Sanabria H, Digman MA, Gratton E, Waxham MN. Spatial diffusivity and availability of intracellular calmodulin. Biophys J. 2008 Dec 15; 95(12):6002-15. PMID: 18820232.
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    98. Watson NB, Nelson E, Digman M, Thornburg JA, Alphenaar BW, McGregor WG. RAD18 and associated proteins are immobilized in nuclear foci in human cells entering S-phase with ultraviolet light-induced damage. Mutat Res. 2008 Dec 15; 648(1-2):23-31. PMID: 18926833.
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    99. Brown CM, Dalal RB, Hebert B, Digman MA, Horwitz AR, Gratton E. Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope. J Microsc. 2008 Jan; 229(Pt 1):78-91. PMID: 18173647.
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    100. Dalal RB, Digman MA, Horwitz AF, Vetri V, Gratton E. Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode. Microsc Res Tech. 2008 Jan; 71(1):69-81. PMID: 17937391.
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    101. Digman MA, Dalal R, Horwitz AF, Gratton E. Mapping the number of molecules and brightness in the laser scanning microscope. Biophys J. 2008 Mar 15; 94(6):2320-32. PMID: 18096627.
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    102. Caiolfa VR, Zamai M, Malengo G, Andolfo A, Madsen CD, Sutin J, Digman MA, Gratton E, Blasi F, Sidenius N. Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J Cell Biol. 2007 Dec 03; 179(5):1067-82. PMID: 18056417.
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    103. Digman MA, Brown CM, Horwitz AR, Mantulin WW, Gratton E. Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophys J. 2008 Apr 01; 94(7):2819-31. PMID: 17993500.
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    104. Digman MA, Caiolfa VR, Zamai M, Gratton E. The phasor approach to fluorescence lifetime imaging analysis. Biophys J. 2008 Jan 15; 94(2):L14-6. PMID: 17981902.
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    105. Gokhale NA, Abraham A, Digman MA, Gratton E, Cho W. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. J Biol Chem. 2005 Dec 30; 280(52):42831-40. PMID: 16230353.
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    106. Digman MA, Brown CM, Sengupta P, Wiseman PW, Horwitz AR, Gratton E. Measuring fast dynamics in solutions and cells with a laser scanning microscope. Biophys J. 2005 Aug; 89(2):1317-27. PMID: 15908582.
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    107. Digman MA, Sengupta P, Wiseman PW, Brown CM, Horwitz AR, Gratton E. Fluctuation correlation spectroscopy with a laser-scanning microscope: exploiting the hidden time structure. Biophys J. 2005 May; 88(5):L33-6. PMID: 15792971.
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    108. Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Melowic HR, Rafter JD, Cho W. Diacylglycerol-induced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon. J Biol Chem. 2005 May 20; 280(20):19784-93. PMID: 15769752.
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    109. Barcellona ML, Gammon S, Hazlett T, Digman MA, Gratton E. Polarized fluorescence correlation spectroscopy of DNA-DAPI complexes. Microsc Res Tech. 2004 Nov; 65(4-5):205-17. PMID: 15630690.
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    110. Inoue M, Digman MA, Cheng M, Breusegem SY, Halaihel N, Sorribas V, Mantulin WW, Gratton E, Barry NP, Levi M. Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity. J Biol Chem. 2004 Nov 19; 279(47):49160-71. PMID: 15355967.
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    111. Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Rafter JD, Melowic HR, Cho W. Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta. J Biol Chem. 2004 Jul 09; 279(28):29501-12. PMID: 15105418.
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    112. Ananthanarayanan B, Stahelin RV, Digman MA, Cho W. Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains. J Biol Chem. 2003 Nov 21; 278(47):46886-94. PMID: 12954613.
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    113. Cho W, Digman M, Ananthanarayanan B, Stahelin RV. Bacterial expression and purification of C1 and C2 domains of protein kinase C isoforms. Methods Mol Biol. 2003; 233:291-8. PMID: 12840516.
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