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Michelle Digman

Title(s)Assistant Professor, Biomedical Engineering
Address3103 Natural Sciences II
Zot 2715
Irvine CA 92697
Phone(949) 824-3255
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    Collapse Research 
    Collapse Research Activities and Funding
    Assessment of the phasor Fluorescence Lifetime Imaging Microscopy (FLIM) Approach in an animal model
    NIH/NICHD R21HD090629Aug 1, 2017 - Jul 31, 2019
    Role: Co-Principal Investigator
    The Big DIPA: Data Image Processing and Analysis
    NIH/NIBIB R25EB022366Sep 30, 2015 - Jun 30, 2018
    Role: Co-Principal Investigator
    Zeiss LSM 710 NLO Confocal Microscope
    NIH/NCRR S10RR027508Apr 15, 2011 - Apr 14, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Caffeine and Cisplatin Effectively Targets the Metabolism of a Triple-Negative Breast Cancer Cell Line Assessed via Phasor-FLIM. Int J Mol Sci. 2020 Apr 01; 21(7). Pascua SM, McGahey GE, Ma N, Wang JJ, Digman MA. PMID: 32244616.
      View in: PubMed   Mentions:    Fields:    
    2. The Phasor FLIM Method Reveals a Link Between a Change in Energy Metabolism and mHtt protein spread in Healthy Mammalian Cells when Co-cultured with Huntington Diseased Cells. Methods Appl Fluoresc. 2020 Apr 01. Sameni S, Zhang R, Digman MA. PMID: 32235053.
      View in: PubMed   Mentions:    Fields:    
    3. A Shift in Central Metabolism Accompanies Virulence Activation in Pseudomonas aeruginosa. mBio. 2020 03 10; 11(2). Perinbam K, Chacko JV, Kannan A, Digman MA, Siryaporn A. PMID: 32156820.
      View in: PubMed   Mentions:    Fields:    
    4. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 2020 03; 22(3):310-320. Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA. PMID: 32144411.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Number and molecular brightness analysis reveals Htt25Q protein aggregation upon the uptake of Htt97Q aggregates. Biochem Biophys Res Commun. 2020 Jan 29; 522(1):133-137. Sameni S, Zhang R, Digman MA. PMID: 31757420.
      View in: PubMed   Mentions: 1     Fields:    
    6. Label-free assessment of pre-implantation embryo quality by the Fluorescence Lifetime Imaging Microscopy (FLIM)-phasor approach. Sci Rep. 2019 09 13; 9(1):13206. Ma N, Mochel NR, Pham PD, Yoo TY, Cho KWY, Digman MA. PMID: 31519916.
      View in: PubMed   Mentions: 1     Fields:    
    7. The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. Nat Cell Biol. 2019 09; 21(9):1127-1137. Trivedi P, Palomba F, Niedzialkowska E, Digman MA, Gratton E, Stukenberg PT. PMID: 31481798.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. NAD+ consumption by PARP1 in response to DNA damage triggers metabolic shift critical for damaged cell survival. Mol Biol Cell. 2019 09 15; 30(20):2584-2597. Murata MM, Kong X, Moncada E, Chen Y, Imamura H, Wang P, Berns MW, Yokomori K, Digman MA. PMID: 31390283.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts. Sci Rep. 2019 08 02; 9(1):11274. Dong Y, Sameni S, Digman MA, Brewer GJ. PMID: 31375701.
      View in: PubMed   Mentions: 1     Fields:    
    10. Number and brightness analysis to study spatio-temporal distribution of the angiotensin II AT1 and the endothelin-1 ETA receptors: Influence of ligand binding. Biochim Biophys Acta Gen Subj. 2019 05; 1863(5):917-924. Planes N, Digman MA, Vanderheyden PPML, Gratton E, Caballero-George C. PMID: 30851407.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    11. Widefield multifrequency fluorescence lifetime imaging using a two-tap complementary metal-oxide semiconductor camera with lateral electric field charge modulators. J Biophotonics. 2019 05; 12(5):e201800223. Chen H, Ma N, Kagawa K, Kawahito S, Digman M, Gratton E. PMID: 30421535.
      View in: PubMed   Mentions: 1     Fields:    
    12. Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy. Geroscience. 2019 02; 41(1):51-67. Dong Y, Digman MA, Brewer GJ. PMID: 30729413.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    13. Label-Free Metabolic Classification of Single Cells in Droplets Using the Phasor Approach to Fluorescence Lifetime Imaging Microscopy. Cytometry A. 2019 01; 95(1):93-100. Ma N, Kamalakshakurup G, Aghaamoo M, Lee AP, Digman MA. PMID: 30536717.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility. Sci Rep. 2018 11 20; 8(1):17094. Mah EJ, Lefebvre AEYT, McGahey GE, Yee AF, Digman MA. PMID: 30459440.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. Feasibility study on mouse live imaging after spinal cord injury and poly(lactide-co-glycolide) bridge implantation. J Biomed Opt. 2018 06; 23(6):1-6. Anzalone A, Chacko JV, Nishi RA, Dumont C, Smith D, Shea LD, Digman MA, Cummings BJ, Anderson AJ. PMID: 29959835.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy. Lab Chip. 2018 05 01; 18(9):1349-1358. Lee DH, Li X, Ma N, Digman MA, Lee AP. PMID: 29638231.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    17. Publisher Correction: Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Sci Rep. 2018 Apr 11; 8(1):6060. Sameni S, Malacrida L, Tan Z, Digman MA. PMID: 29643420.
      View in: PubMed   Mentions:    Fields:    
    18. PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov. 2018 07; 8(7):866-883. Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL. PMID: 29572236.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    19. Viral highway to nucleus exposed by image correlation analyses. Sci Rep. 2018 01 18; 8(1):1152. Mäntylä E, Chacko JV, Aho V, Parrish CR, Shahin V, Kann M, Digman MA, Gratton E, Vihinen-Ranta M. PMID: 29348472.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    20. Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Sci Rep. 2018 01 15; 8(1):734. Sameni S, Malacrida L, Tan Z, Digman MA. PMID: 29335600.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    21. Absence of REV3L promotes p53-regulated cancer cell metabolism in cisplatin-treated lung carcinoma cells. Biochem Biophys Res Commun. 2018 01 29; 496(1):199-204. Kong L, Murata MM, Digman MA. PMID: 29307819.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    22. Quantitative image mean squared displacement (iMSD) analysis of the dynamics of profilin 1 at the membrane of live cells. Methods. 2018 05 01; 140-141:119-125. Davey RJ, Digman MA, Gratton E, Moens PDJ. PMID: 29242135.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Tracking Functional Tumor Cell Subpopulations of Malignant Glioma by Phasor Fluorescence Lifetime Imaging Microscopy of NADH. Cancers (Basel). 2017 Dec 06; 9(12). Trinh AL, Chen H, Chen Y, Hu Y, Li Z, Siegel ER, Linskey ME, Wang PH, Digman MA, Zhou YH. PMID: 29211022.
      View in: PubMed   Mentions:
    24. An apolipoprotein-enriched biomolecular corona switches the cellular uptake mechanism and trafficking pathway of lipid nanoparticles. Nanoscale. 2017 Nov 16; 9(44):17254-17262. Digiacomo L, Cardarelli F, Pozzi D, Palchetti S, Digman MA, Gratton E, Capriotti AL, Mahmoudi M, Caracciolo G. PMID: 29115333.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    25. Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 07 26; 9(400). Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W. PMID: 28747514.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    26. Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation. Mol Biol Cell. 2017 Jul 15; 28(15):2135-2145. Herrington KA, Trinh AL, Dang C, O'Shaughnessy E, Hahn KM, Gratton E, Digman MA, Sütterlin C. PMID: 28539409.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    27. Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography. Integr Biol (Camb). 2017 02 20; 9(2):145-155. Liang EI, Mah EJ, Yee AF, Digman MA. PMID: 28092391.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    28. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. PMID: 27914984.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    29. The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease. Sci Rep. 2016 10 07; 6:34755. Sameni S, Syed A, Marsh JL, Digman MA. PMID: 27713486.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary. Biol Reprod. 2016 12; 95(6):129. Cinco R, Digman MA, Gratton E, Luderer U. PMID: 27683265.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Self-assisted optothermal trapping of gold nanorods under two-photon excitation. Methods Appl Fluoresc. 2016 09 06; 4(3):035003. Chen H, Gratton E, Digman MA. PMID: 28355163.
      View in: PubMed   Mentions:    Fields:    
    32. Highly Charged Particles Cause a Larger Current Blockage in Micropores Compared to Neutral Particles. ACS Nano. 2016 09 27; 10(9):8413-22. Qiu Y, Lin CY, Hinkle P, Plett TS, Yang C, Chacko JV, Digman MA, Yeh LH, Hsu JP, Siwy ZS. PMID: 27532683.
      View in: PubMed   Mentions: 1     Fields:    
    33. Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles. Acta Biomater. 2016 09 15; 42:189-198. Digiacomo L, Digman MA, Gratton E, Caracciolo G. PMID: 27449340.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Elucidation of Exosome Migration across the Blood-Brain Barrier Model In Vitro. Cell Mol Bioeng. 2016 Dec; 9(4):509-529. Chen CC, Liu L, Ma F, Wong CW, Guo XE, Chacko JV, Farhoodi HP, Zhang SX, Zimak J, Ségaliny A, Riazifar M, Pham V, Digman MA, Pone EJ, Zhao W. PMID: 28392840.
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    35. Measurements of absolute concentrations of NADH in cells using the phasor FLIM method. Biomed Opt Express. 2016 Jul 01; 7(7):2441-52. Ma N, Digman MA, Malacrida L, Gratton E. PMID: 27446681.
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    36. Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. Elife. 2016 Apr 12; 5:e14034. Sosnik J, Zheng L, Rackauckas CV, Digman M, Gratton E, Nie Q, Schilling TF. PMID: 27067377.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    37. Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection. Lab Chip. 2015 Nov 07; 15(21):4217-26. Zhang K, Kang DK, Ali MM, Liu L, Labanieh L, Lu M, Riazifar H, Nguyen TN, Zell JA, Digman MA, Gratton E, Li J, Zhao W. PMID: 26387763.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Characterization of exogenous DNA mobility in live cells through fluctuation correlation spectroscopy. Sci Rep. 2015 Sep 10; 5:13848. Mieruszynski S, Digman MA, Gratton E, Jones MR. PMID: 26354725.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    39. Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers. J Cell Biol. 2015 Aug 17; 210(4):629-46. Hendrix J, Baumgärtel V, Schrimpf W, Ivanchenko S, Digman MA, Gratton E, Kräusslich HG, Müller B, Lamb DC. PMID: 26283800.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    40. Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus. J Virol. 2015 Sep; 89(18):9440-53. Adu-Gyamfi E, Johnson KA, Fraser ME, Scott JL, Soni SP, Jones KR, Digman MA, Gratton E, Tessier CR, Stahelin RV. PMID: 26136573.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    41. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Mol Psychiatry. 2015 Nov; 20(11):1286-93. Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG. PMID: 26100538.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    42. Live Cell Characterization of DNA Aggregation Delivered through Lipofection. Sci Rep. 2015 May 27; 5:10528. Mieruszynski S, Briggs C, Digman MA, Gratton E, Jones MR. PMID: 26013547.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    43. Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium. Biophys J. 2015 Apr 07; 108(7):1633-1644. Olivera-Couto A, Salzman V, Mailhos M, Digman MA, Gratton E, Aguilar PS. PMID: 25863055.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    44. Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis. Biophys J. 2015 Mar 24; 108(6):1448-1458. Moens PDJ, Digman MA, Gratton E. PMID: 25809257.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    45. Spectral properties and dynamics of gold nanorods revealed by EMCCD-based spectral phasor method. Microsc Res Tech. 2015 Apr; 78(4):283-93. Chen H, Gratton E, Digman MA. PMID: 25684346.
      View in: PubMed   Mentions: 2     Fields:    
    46. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun. 2014 Nov 13; 5:5427. Kang DK, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W. PMID: 25391809.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    47. A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress. Viruses. 2014 Oct 17; 6(10):3837-54. Adu-Gyamfi E, Soni SP, Jee CS, Digman MA, Gratton E, Stahelin RV. PMID: 25330123.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    48. Nanoimaging of focal adhesion dynamics in 3D. PLoS One. 2014; 9(6):e99896. Chiu CL, Aguilar JS, Tsai CY, Wu G, Gratton E, Digman MA. PMID: 24959851.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    49. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. PMID: 24825347.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimalsCells
    50. Enhanced emission of fluorophores on shrink-induced wrinkled composite structures. Opt Mater Express. 2014; 4(4):753-763. Sharma H, Digman MA, Felsinger N, Gratton E, Khine M. PMID: 25383253.
      View in: PubMed   Mentions:
    51. Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: interplay between nanostructure and composition. Biochim Biophys Acta. 2014 Mar; 1838(3):957-67. Pozzi D, Marchini C, Cardarelli F, Salomone F, Coppola S, Montani M, Zabaleta ME, Digman MA, Gratton E, Colapicchioni V, Caracciolo G. PMID: 24296066.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    52. Measuring actin flow in 3D cell protrusions. Biophys J. 2013 Oct 15; 105(8):1746-55. Chiu CL, Digman MA, Gratton E. PMID: 24138850.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    53. A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells. Biochim Biophys Acta. 2014 Jan; 1840(1):315-21. James NG, Digman MA, Ross JA, Barylko B, Wang L, Li J, Chen Y, Mueller JD, Gratton E, Albanesi JP, Jameson DM. PMID: 24016602.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    54. Cell matrix remodeling ability shown by image spatial correlation. J Biophys. 2013; 2013:532030. Chiu CL, Digman MA, Gratton E. PMID: 23935614.
      View in: PubMed   Mentions:
    55. Detecting Pyronin Y labeled RNA transcripts in live cell microenvironments by phasor-FLIM analysis. Methods Appl Fluoresc. 2013 Mar 01; 1(1):015001. Andrews LM, Jones MR, Digman MA, Gratton E. PMID: 24563776.
      View in: PubMed   Mentions: 2     Fields:    
    56. The role of cytoskeleton networks on lipid-mediated delivery of DNA. Ther Deliv. 2013 Feb; 4(2):191-202. Coppola S, Cardarelli F, Pozzi D, Estrada LC, Digman MA, Gratton E, Bifone A, Marianecci C, Caracciolo G. PMID: 23343159.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    57. The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress. J Biol Chem. 2013 Feb 22; 288(8):5779-89. Adu-Gyamfi E, Soni SP, Xue Y, Digman MA, Gratton E, Stahelin RV. PMID: 23297401.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    58. Raster image correlation spectroscopy and number and brightness analysis. Methods Enzymol. 2013; 518:121-44. Digman MA, Stakic M, Gratton E. PMID: 23276538.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    59. Quantitative measurement of intracellular transport of nanocarriers by spatio-temporal image correlation spectroscopy. Methods Appl Fluoresc. 2013; 1(1). Coppola S, Pozzi D, De Sanctis SC, Digman MA, Gratton E, Caracciolo G. PMID: 24376913.
      View in: PubMed   Mentions: 4     Fields:    
    60. Spectral phasor analysis of Pyronin Y labeled RNA microenvironments in living cells. Biomed Opt Express. 2013 Jan 01; 4(1):171-7. Andrews LM, Jones MR, Digman MA, Gratton E. PMID: 23304656.
      View in: PubMed   Mentions:
    61. Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):135-40. Hinde E, Digman MA, Hahn KM, Gratton E. PMID: 23248275.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    62. Real-time analysis of metabolic activity within Lactobacillus acidophilus by phasor fluorescence lifetime imaging microscopy of NADH. Curr Microbiol. 2013 Apr; 66(4):365-7. Torno K, Wright BK, Jones MR, Digman MA, Gratton E, Phillips M. PMID: 23233088.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    63. Organic nitrogen uptake by arbuscular mycorrhizal fungi in a boreal forest. Soil Biol Biochem. 2012 Dec; 55. Whiteside MD, Digman MA, Gratton E, Treseder KK. PMID: 24371363.
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    64. Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein. Biophys J. 2012 Nov 07; 103(9):L41-3. Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. PMID: 23199932.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    65. Phasor-FLIM analysis of NADH distribution and localization in the nucleus of live progenitor myoblast cells. Microsc Res Tech. 2012 Dec; 75(12):1717-22. Wright BK, Andrews LM, Jones MR, Stringari C, Digman MA, Gratton E. PMID: 23019116.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    66. Intracellular trafficking of cationic liposome-DNA complexes in living cells. Soft Matter. 2012 Aug 14; 8(30):7919-7927. Coppola S, Estrada LC, Digman MA, Pozzi D, Cardarelli F, Gratton E, Caracciolo G. PMID: 25152766.
      View in: PubMed   Mentions: 8     Fields:    
    67. NADH distribution in live progenitor stem cells by phasor-fluorescence lifetime image microscopy. Biophys J. 2012 Jul 03; 103(1):L7-9. Wright BK, Andrews LM, Markham J, Jones MR, Stringari C, Digman MA, Gratton E. PMID: 22828352.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    68. Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis. Biophys J. 2012 Jun 06; 102(11):2517-25. Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. PMID: 22713567.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    69. Number and brightness analysis of LRRK2 oligomerization in live cells. Biophys J. 2012 Jun 06; 102(11):L41-3. James NG, Digman MA, Gratton E, Barylko B, Ding X, Albanesi JP, Goldberg MS, Jameson DM. PMID: 22713584.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    70. Intracellular pH measurements made simple by fluorescent protein probes and the phasor approach to fluorescence lifetime imaging. Chem Commun (Camb). 2012 May 25; 48(42):5127-9. Battisti A, Digman MA, Gratton E, Storti B, Beltram F, Bizzarri R. PMID: 22517076.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    71. Free extracellular diffusion creates the Dpp morphogen gradient of the Drosophila wing disc. Curr Biol. 2012 Apr 24; 22(8):668-75. Zhou S, Lo WC, Suhalim JL, Digman MA, Gratton E, Nie Q, Lander AD. PMID: 22445299.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    72. Scanning image correlation spectroscopy. Bioessays. 2012 May; 34(5):377-85. Digman MA, Gratton E. PMID: 22415853.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    73. Changes in chromatin compaction during the cell cycle revealed by micrometer-scale measurement of molecular flow in the nucleus. Biophys J. 2012 Feb 08; 102(3):691-7. Hinde E, Cardarelli F, Digman MA, Gratton E. PMID: 22325293.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    74. Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D. Integr Biol (Camb). 2012 Apr; 4(4):431-9. Kniazeva E, Weidling JW, Singh R, Botvinick EL, Digman MA, Gratton E, Putnam AJ. PMID: 22281872.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    75. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure. 2011 Dec 07; 19(12):1826-36. Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU. PMID: 22153505.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    76. Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microsc Res Tech. 2012 Mar; 75(3):271-81. Hinde E, Digman MA, Welch C, Hahn KM, Gratton E. PMID: 21858900.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    77. Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13582-7. Stringari C, Cinquin A, Cinquin O, Digman MA, Donovan PJ, Gratton E. PMID: 21808026.
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    78. Factors determining the superior performance of lipid/DNA/protammine nanoparticles over lipoplexes. J Med Chem. 2011 Jun 23; 54(12):4160-71. Caracciolo G, Pozzi D, Capriotti AL, Marianecci C, Carafa M, Marchini C, Montani M, Amici A, Amenitsch H, Digman MA, Gratton E, Sanchez SS, Laganà A. PMID: 21615134.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    79. The impact of mitotic versus interphase chromatin architecture on the molecular flow of EGFP by pair correlation analysis. Biophys J. 2011 Apr 06; 100(7):1829-36. Hinde E, Cardarelli F, Digman MA, Kershner A, Kimble J, Gratton E. PMID: 21463597.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    80. Nanometer-scale imaging by the modulation tracking method. J Biophotonics. 2011 Jun; 4(6):415-24. Lanzano L, Digman MA, Fwu P, Giral H, Levi M, Gratton E. PMID: 21462350.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    81. Role of temperature-independent lipoplex-cell membrane interactions in the efficiency boost of multicomponent lipoplexes. Cancer Gene Ther. 2011 Aug; 18(8):543-52. Marchini C, Pozzi D, Montani M, Alfonsi C, Amici A, Candeloro De Sanctis S, Digman MA, Sanchez S, Gratton E, Amenitsch H, Fabbretti A, Gualerzi CO, Caracciolo G. PMID: 21394110.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    82. Fluctuation methods to study protein aggregation in live cells: concanavalin A oligomers formation. Biophys J. 2011 Feb 02; 100(3):774-783. Vetri V, Ossato G, Militello V, Digman MA, Leone M, Gratton E. PMID: 21281593.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    83. Oligomerization state of dynamin 2 in cell membranes using TIRF and number and brightness analysis. Biophys J. 2011 Feb 02; 100(3):L15-L17. Ross JA, Digman MA, Wang L, Gratton E, Albanesi JP, Jameson DM. PMID: 21281565.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    84. Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions. Biophys J. 2011 Feb 02; 100(3):583-592. Choi CK, Zareno J, Digman MA, Gratton E, Horwitz AR. PMID: 21281572.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    85. Lessons in fluctuation correlation spectroscopy. Annu Rev Phys Chem. 2011; 62:645-68. Digman MA, Gratton E. PMID: 21219151.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    86. Quantifying translational mobility in neurons: comparison between current optical techniques. J Neurosci. 2010 Dec 08; 30(49):16409-16. Kim SA, Sanabria H, Digman MA, Gratton E, Schwille P, Zipfel WR, Waxham MN. PMID: 21147979.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    87. Raster image correlation spectroscopy in live cells. Nat Protoc. 2010 Nov; 5(11):1761-74. Rossow MJ, Sasaki JM, Digman MA, Gratton E. PMID: 21030952.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    88. Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids. PLoS One. 2010 Oct 11; 5(10):e13279. Presman DM, Alvarez LD, Levi V, Eduardo S, Digman MA, Martí MA, Veleiro AS, Burton G, Pecci A. PMID: 20949009.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    89. Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization. Mol Biol Cell. 2010 Nov 15; 21(22):4028-41. Kuo WJ, Digman MA, Lander AD. PMID: 20861306.
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    90. In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependent molecular flow. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16560-5. Hinde E, Cardarelli F, Digman MA, Gratton E. PMID: 20823232.
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    91. A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis. Biophys J. 2010 Jun 16; 98(12):3078-85. Ossato G, Digman MA, Aiken C, Lukacsovich T, Marsh JL, Gratton E. PMID: 20550921.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    92. Molecular basis of the potent membrane-remodeling activity of the epsin 1 N-terminal homology domain. J Biol Chem. 2010 Jan 01; 285(1):531-40. Yoon Y, Tong J, Lee PJ, Albanese A, Bhardwaj N, Källberg M, Digman MA, Lu H, Gratton E, Shin YK, Cho W. PMID: 19880963.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    93. Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct; 1(2):273-282. Digman MA, Gratton E. PMID: 20835996.
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    94. Imaging barriers to diffusion by pair correlation functions. Biophys J. 2009 Jul 22; 97(2):665-73. Digman MA, Gratton E. PMID: 19619481.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    95. Measuring diffusion of lipid-like probes in artificial and natural membranes by raster image correlation spectroscopy (RICS): use of a commercial laser-scanning microscope with analog detection. Langmuir. 2009 May 05; 25(9):5209-18. Gielen E, Smisdom N, vandeVen M, De Clercq B, Gratton E, Digman M, Rigo JM, Hofkens J, Engelborghs Y, Ameloot M. PMID: 19260653.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    96. Efficient escape from endosomes determines the superior efficiency of multicomponent lipoplexes. J Phys Chem B. 2009 Apr 16; 113(15):4995-7. Caracciolo G, Caminiti R, Digman MA, Gratton E, Sanchez S. PMID: 19301832.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    97. Analysis of diffusion and binding in cells using the RICS approach. Microsc Res Tech. 2009 Apr; 72(4):323-32. Digman MA, Gratton E. PMID: 19067357.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    98. One photon up, one photon down. Nat Biotechnol. 2009 Feb; 27(2):147-8. Gratton E, Digman M. PMID: 19204693.
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    99. Stoichiometry of molecular complexes at adhesions in living cells. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2170-5. Digman MA, Wiseman PW, Choi C, Horwitz AR, Gratton E. PMID: 19168634.
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    100. Detecting protein complexes in living cells from laser scanning confocal image sequences by the cross correlation raster image spectroscopy method. Biophys J. 2009 Jan; 96(2):707-16. Digman MA, Wiseman PW, Horwitz AR, Gratton E. PMID: 19167315.
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    101. Spatial diffusivity and availability of intracellular calmodulin. Biophys J. 2008 Dec 15; 95(12):6002-15. Sanabria H, Digman MA, Gratton E, Waxham MN. PMID: 18820232.
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    102. RAD18 and associated proteins are immobilized in nuclear foci in human cells entering S-phase with ultraviolet light-induced damage. Mutat Res. 2008 Dec 15; 648(1-2):23-31. Watson NB, Nelson E, Digman M, Thornburg JA, Alphenaar BW, McGregor WG. PMID: 18926833.
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    103. Raster image correlation spectroscopy (RICS) for measuring fast protein dynamics and concentrations with a commercial laser scanning confocal microscope. J Microsc. 2008 Jan; 229(Pt 1):78-91. Brown CM, Dalal RB, Hebert B, Digman MA, Horwitz AR, Gratton E. PMID: 18173647.
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    104. Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode. Microsc Res Tech. 2008 Jan; 71(1):69-81. Dalal RB, Digman MA, Horwitz AF, Vetri V, Gratton E. PMID: 17937391.
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    105. Mapping the number of molecules and brightness in the laser scanning microscope. Biophys J. 2008 Mar 15; 94(6):2320-32. Digman MA, Dalal R, Horwitz AF, Gratton E. PMID: 18096627.
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    106. Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J Cell Biol. 2007 Dec 03; 179(5):1067-82. Caiolfa VR, Zamai M, Malengo G, Andolfo A, Madsen CD, Sutin J, Digman MA, Gratton E, Blasi F, Sidenius N. PMID: 18056417.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    107. Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophys J. 2008 Apr 01; 94(7):2819-31. Digman MA, Brown CM, Horwitz AR, Mantulin WW, Gratton E. PMID: 17993500.
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    108. The phasor approach to fluorescence lifetime imaging analysis. Biophys J. 2008 Jan 15; 94(2):L14-6. Digman MA, Caiolfa VR, Zamai M, Gratton E. PMID: 17981902.
      View in: PubMed   Mentions: 209     Fields:    Translation:AnimalsCells
    109. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. J Biol Chem. 2005 Dec 30; 280(52):42831-40. Gokhale NA, Abraham A, Digman MA, Gratton E, Cho W. PMID: 16230353.
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    110. Measuring fast dynamics in solutions and cells with a laser scanning microscope. Biophys J. 2005 Aug; 89(2):1317-27. Digman MA, Brown CM, Sengupta P, Wiseman PW, Horwitz AR, Gratton E. PMID: 15908582.
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    111. Fluctuation correlation spectroscopy with a laser-scanning microscope: exploiting the hidden time structure. Biophys J. 2005 May; 88(5):L33-6. Digman MA, Sengupta P, Wiseman PW, Brown CM, Horwitz AR, Gratton E. PMID: 15792971.
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    112. Diacylglycerol-induced membrane targeting and activation of protein kinase Cepsilon: mechanistic differences between protein kinases Cdelta and Cepsilon. J Biol Chem. 2005 May 20; 280(20):19784-93. Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Melowic HR, Rafter JD, Cho W. PMID: 15769752.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    113. Polarized fluorescence correlation spectroscopy of DNA-DAPI complexes. Microsc Res Tech. 2004 Nov; 65(4-5):205-17. Barcellona ML, Gammon S, Hazlett T, Digman MA, Gratton E. PMID: 15630690.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    114. Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity. J Biol Chem. 2004 Nov 19; 279(47):49160-71. Inoue M, Digman MA, Cheng M, Breusegem SY, Halaihel N, Sorribas V, Mantulin WW, Gratton E, Barry NP, Levi M. PMID: 15355967.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    115. Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta. J Biol Chem. 2004 Jul 09; 279(28):29501-12. Stahelin RV, Digman MA, Medkova M, Ananthanarayanan B, Rafter JD, Melowic HR, Cho W. PMID: 15105418.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    116. Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains. J Biol Chem. 2003 Nov 21; 278(47):46886-94. Ananthanarayanan B, Stahelin RV, Digman MA, Cho W. PMID: 12954613.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    117. Bacterial expression and purification of C1 and C2 domains of protein kinase C isoforms. Methods Mol Biol. 2003; 233:291-8. Cho W, Digman M, Ananthanarayanan B, Stahelin RV. PMID: 12840516.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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