Ping H Wang

Title(s)Professor Emeritus, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    Collapse Research 
    Collapse Research Activities and Funding
    Insulin's Control of Myocardial Mitochondria Bioenergetics and Biogenesis
    NIH R01HL096987Apr 2, 2010 - Mar 31, 2015
    Role: Principal Investigator
    Regulation of Stress in Diabetic Cardiomyopathy
    NIH R21HL067988Sep 1, 2001 - Aug 31, 2004
    Role: Principal Investigator
    Molecular Actions Of IGF In Cardiac Muscle
    NIH R01HL055533Aug 1, 1996 - Apr 30, 2006
    Role: Principal Investigator
    MOLECULAR ACTIONS OF IGF I IN CARDIAC MUSCLE
    NIH R29HL055533Aug 1, 1996 - Dec 31, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming. Cell Rep. 2023 06 27; 42(6):112590. Sato S, Hishida T, Kinouchi K, Hatanaka F, Li Y, Nguyen Q, Chen Y, Wang PH, Kessenbrock K, Li W, Izpisua Belmonte JC, Sassone-Corsi P. PMID: 37261952.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Anterograde regulation of mitochondrial genes and FGF21 signaling by hepatic LSD1. JCI Insight. 2021 09 08; 6(17). Cao Y, Tang L, Du K, Paraiso K, Sun Q, Liu Z, Ye X, Fang Y, Yuan F, Chen H, Chen Y, Wang X, Yu C, Blitz IL, Wang PH, Huang L, Cheng H, Lu X, Cho KW, Seldin M, Fang Z, Yang Q. PMID: 34314389; PMCID: PMC8492328.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Tubular mitochondrial AKT1 is activated during ischemia reperfusion injury and has a critical role in predisposition to chronic kidney disease. Kidney Int. 2021 04; 99(4):870-884. Lin HY, Chen Y, Chen YH, Ta AP, Lee HC, MacGregor GR, Vaziri ND, Wang PH. PMID: 33316281; PMCID: PMC7987863.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    4. Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells. Sci Rep. 2019 07 09; 9(1):9919. Chen YH, Su CC, Deng W, Lock LF, Donovan PJ, Kayala MA, Baldi P, Lee HC, Chen Y, Wang PH. PMID: 31289326; PMCID: PMC6616364.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    5. Urine mitochondrial DNA and diabetic nephropathy-a new frontier. Nephrol Dial Transplant. 2018 05 01; 33(5):719-721. Lau WL, Lin HY, Wang PH. PMID: 29401284.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Tracking Functional Tumor Cell Subpopulations of Malignant Glioma by Phasor Fluorescence Lifetime Imaging Microscopy of NADH. Cancers (Basel). 2017 Dec 06; 9(12). Trinh AL, Chen H, Chen Y, Hu Y, Li Z, Siegel ER, Linskey ME, Wang PH, Digman MA, Zhou YH. PMID: 29211022; PMCID: PMC5742816.
      View in: PubMed   Mentions: 22  
    7. The changing landscape of diabetes prevalence among first-generation Asian immigrants in California from 2003 to 2013. BMJ Open Diabetes Res Care. 2017; 5(1):e000327. Fan W, Lee DH, Billimek J, Choi S, Wang PH. PMID: 28176974; PMCID: PMC5278214.
      View in: PubMed   Mentions: 3  
    8. Deciphering the Effect of Metformin on Prostate Cancer Risk by Ethnicity. Cancer Prev Res (Phila). 2016 10; 9(10):777-778. Uchio E, Meyskens FL, Wang PH. PMID: 27432345; PMCID: PMC5098894.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Hepatic proteomic analysis revealed altered metabolic pathways in insulin resistant Akt1(+/-)/Akt2(-/-) mice. Metabolism. 2015 Dec; 64(12):1694-703. Pedersen BA, Wang W, Taylor JF, Khattab OS, Chen YH, Edwards RA, Yazdi PG, Wang PH. PMID: 26455965; PMCID: PMC4641788.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    10. Increasing Nucleosome Occupancy Is Correlated with an Increasing Mutation Rate so Long as DNA Repair Machinery Is Intact. PLoS One. 2015; 10(8):e0136574. Yazdi PG, Pedersen BA, Taylor JF, Khattab OS, Chen YH, Chen Y, Jacobsen SE, Wang PH. PMID: 26308346; PMCID: PMC4550472.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. Nucleosome Organization in Human Embryonic Stem Cells. PLoS One. 2015; 10(8):e0136314. Yazdi PG, Pedersen BA, Taylor JF, Khattab OS, Chen YH, Chen Y, Jacobsen SE, Wang PH. PMID: 26305225; PMCID: PMC4549264.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Pemphigus vulgaris antibodies target the mitochondrial nicotinic acetylcholine receptors that protect keratinocytes from apoptolysis. Int Immunopharmacol. 2015 Nov; 29(1):76-80. Chernyavsky A, Chen Y, Wang PH, Grando SA. PMID: 25998908.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    13. Linking differential radiation responses to glioma heterogeneity. Oncotarget. 2014 Mar 30; 5(6):1657-65. Ke C, Tran K, Chen Y, Di Donato AT, Yu L, Hu Y, Linskey ME, Wang PH, Limoli CL, Zhou YH. PMID: 24722169; PMCID: PMC4039238.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    14. Protein kinase B (PKB/AKT1) formed signaling complexes with mitochondrial proteins and prevented glycolytic energy dysfunction in cultured cardiomyocytes during ischemia-reperfusion injury. Endocrinology. 2014 May; 155(5):1618-28. Deng W, Leu HB, Chen Y, Chen YH, Epperson CM, Juang C, Wang PH. PMID: 24601882; PMCID: PMC3990846.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    15. Renoprotective mechanisms of ischemic postconditioning in ischemia-reperfusion injury: improved mitochondrial function and integrity. Nephrol Dial Transplant. 2013 Nov; 28(11):2667-9. Moradi H, Wang PH. PMID: 24169608; PMCID: PMC3811058.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Skeletal muscle mitochondrial depletion and dysfunction in chronic kidney disease. Int J Clin Exp Med. 2013; 6(7):532-9. Yazdi PG, Moradi H, Yang JY, Wang PH, Vaziri ND. PMID: 23936591; PMCID: PMC3731184.
      View in: PubMed   Mentions: 32  
    17. Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2239-48. Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. PMID: 23729813; PMCID: PMC3683782.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    18. Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium. J Mol Cell Cardiol. 2013 Jun; 59:167-75. Yang JY, Deng W, Chen Y, Fan W, Baldwin KM, Jope RS, Wallace DC, Wang PH. PMID: 23500391; PMCID: PMC3872535.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    19. Cardiovascular effects of anti-diabetic medications in type 2 diabetes mellitus. Curr Cardiol Rep. 2013 Jan; 15(1):327. Singh S, Bhat J, Wang PH. PMID: 23250663.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cells. Am J Physiol Heart Circ Physiol. 2012 Feb 01; 302(3):H716-23. Su CC, Yang JY, Leu HB, Chen Y, Wang PH. PMID: 22081709; PMCID: PMC3353787.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    21. 18F-Fallypride PET of pancreatic islets: in vitro and in vivo rodent studies. J Nucl Med. 2011 Jul; 52(7):1125-32. Garcia A, Mirbolooki MR, Constantinescu C, Pan ML, Sevrioukov E, Milne N, Wang PH, Lakey J, Chandy KG, Mukherjee J. PMID: 21680697.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    22. Insulin stimulates Akt translocation to mitochondria: implications on dysregulation of mitochondrial oxidative phosphorylation in diabetic myocardium. J Mol Cell Cardiol. 2009 Jun; 46(6):919-26. Yang JY, Yeh HY, Lin K, Wang PH. PMID: 19249309; PMCID: PMC3872534.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    23. Bidirectional regulation of upstream IGF-I/insulin receptor signaling and downstream FOXO1 in cardiomyocytes. J Endocrinol. 2007 Jan; 192(1):149-58. Liu TJ, Lai HC, Ting CT, Wang PH. PMID: 17210752.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    24. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17414-9. Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG. PMID: 17088564; PMCID: PMC1859943.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimalsCells
    25. Downregulation of the constitutively expressed Hsc70 in diabetic myocardium is mediated by insulin deficiency. J Endocrinol. 2006 Aug; 190(2):433-40. Chen HS, Jia J, Su HF, Lin HD, Chen JW, Lin SJ, Yang JY, Lai HC, Mestril R, Wang PH. PMID: 16899576.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure. Endocrinology. 2006 Feb; 147(2):827-34. Su HF, Samsamshariat A, Fu J, Shan YX, Chen YH, Piomelli D, Wang PH. PMID: 16269455.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    27. IGF-I is a matter of heart. Growth Horm IGF Res. 2005 Apr; 15(2):89-94. Saetrum Opgaard O, Wang PH. PMID: 15809013.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    28. Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium. Diabetes. 2005 Jan; 54(1):175-81. Chen HS, Shan YX, Yang TL, Lin HD, Chen JW, Lin SJ, Wang PH. PMID: 15616026.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    29. Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA. J Biol Chem. 2004 Nov 12; 279(46):47419-30. Jang GM, Leong LE, Hoang LT, Wang PH, Gutman GA, Semler BL. PMID: 15339906.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    30. Growing pains in the pursuit of diabetes prevention. Lancet. 2004 Mar 20; 363(9413):910. Wang PH. PMID: 15043953.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    31. Using DNA microarray to identify Sp1 as a transcriptional regulatory element of insulin-like growth factor 1 in cardiac muscle cells. Circ Res. 2003 Dec 12; 93(12):1202-9. Li T, Chen YH, Liu TJ, Jia J, Hampson S, Shan YX, Kibler D, Wang PH. PMID: 14593001.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    32. Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy. J Biol Chem. 2003 Nov 14; 278(46):45492-8. Shan YX, Yang TL, Mestril R, Wang PH. PMID: 12970367.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    33. Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells. J Mol Cell Cardiol. 2003 Sep; 35(9):1135-43. Shan YX, Liu TJ, Su HF, Samsamshariat A, Mestril R, Wang PH. PMID: 12967636.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    34. Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway. Mol Cell Endocrinol. 2003 Jul 31; 205(1-2):99-106. Lai HC, Liu TJ, Ting CT, Sharma PM, Wang PH. PMID: 12890571.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    35. IGF I induction of p53 requires activation of MAP kinase in cardiac muscle cells. Biochem Biophys Res Commun. 1998 Apr 28; 245(3):912-7. Wang PH, Schaaf GJ, Chen WH, Feng J, Prins BA, Levin ER, Bahl JJ. PMID: 9588214.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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