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Borrelli, Emiliana

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMicrobiology and Molecular Genetics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-3875, 4-6738
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    Collapse Research 
    Collapse Research Activities and Funding
    Drugs of abuse, Dopamine and the Circadian Clock: a Metabolomic Study
    NIH/NIDA R21DA035600Apr 1, 2013 - Mar 31, 2015
    Role: Co-Principal Investigator
    Determining the role of dopamine D2L versus D2S receptors in vivo
    NIH/NIDA R21DA033554Jun 1, 2012 - May 31, 2014
    Role: Principal Investigator
    Presynaptic versus postsynaptic functions of dopamine D2 receptors in the respons
    NIH/NIDA R01DA024689Sep 30, 2008 - May 31, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Kinouchi K, Wang C, Swerdloff R, Nadeef S, Masri S, Magistretti P, Orlando V, Borrelli E, Uhlenhaut NH, Baldi P, Adamski J, Tschöp MH, Eckel-Mahan K, Sassone-Corsi P. Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks. Cell. 2018 Sep 06; 174(6):1571-1585.e11. PMID: 30193114.
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    2. Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F. Publisher Correction: Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment. Nat Commun. 2018 Aug 29; 9(1):3560. PMID: 30158661.
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    3. Scheggia D, Mastrogiacomo R, Mereu M, Sannino S, Straub RE, Armando M, Managò F, Guadagna S, Piras F, Zhang F, Kleinman JE, Hyde TM, Kaalund SS, Pontillo M, Orso G, Caltagirone C, Borrelli E, De Luca MA, Vicari S, Weinberger DR, Spalletta G, Papaleo F. Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment. Nat Commun. 2018 Jun 11; 9(1):2265. PMID: 29891954.
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    4. Radl D, Chiacchiaretta M, Lewis RG, Brami-Cherrier K, Arcuri L, Borrelli E. Differential regulation of striatal motor behavior and related cellular responses by dopamine D2L and D2S isoforms. Proc Natl Acad Sci U S A. 2018 Jan 02; 115(1):198-203. PMID: 29255027.
      View in: PubMed
    5. Robinson BG, Condon AF, Radl D, Borrelli E, Williams JT, Neve KA. Cocaine-induced adaptation of dopamine D2S, but not D2L autoreceptors. Elife. 2017 Nov 20; 6. PMID: 29154756.
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    6. Rose SJ, Pack TF, Peterson SM, Payne K, Borrelli E, Caron MG. Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and ß-Arrestin to Dopamine-Dependent Functions. Neuropsychopharmacology. 2018 Apr; 43(5):1164-1173. PMID: 29068002.
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    7. Li M, Borrelli E, Magistretti PJ, Izpisua Belmonte JC, Sassone-Corsi P, Orlando V. Gathering by the Red Sea highlights links between environment and epigenetics. Nat Struct Mol Biol. 2017 06 06; 24(6):491-493. PMID: 28586330.
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    8. Urs NM, Gee SM, Pack TF, McCorvy JD, Evron T, Snyder JC, Yang X, Rodriguiz RM, Borrelli E, Wetsel WC, Jin J, Roth BL, O'Donnell P, Caron MG. Distinct cortical and striatal actions of a ß-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8178-E8186. PMID: 27911814.
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    9. Kharkwal G, Radl D, Lewis R, Borrelli E. Dopamine D2 receptors in striatal output neurons enable the psychomotor effects of cocaine. Proc Natl Acad Sci U S A. 2016 10 11; 113(41):11609-11614. PMID: 27671625.
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    10. Kharkwal G, Brami-Cherrier K, Lizardi-Ortiz JE, Nelson AB, Ramos M, Del Barrio D, Sulzer D, Kreitzer AC, Borrelli E. Parkinsonism Driven by Antipsychotics Originates from Dopaminergic Control of Striatal Cholinergic Interneurons. Neuron. 2016 07 06; 91(1):67-78. PMID: 27387649.
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    11. Zhang Y, Wang C, Wang L, Parks GS, Zhang X, Guo Z, Ke Y, Li KW, Kim MK, Vo B, Borrelli E, Ge G, Yang L, Wang Z, Garcia-Fuster MJ, Luo ZD, Liang X, Civelli O. A novel analgesic isolated from a traditional Chinese medicine. Curr Biol. 2014 Jan 20; 24(2):117-23. PMID: 24388848; PMCID: PMC3912990.
    12. Bozzi Y, Borrelli E. The role of dopamine signaling in epileptogenesis. Front Cell Neurosci. 2013 Sep 17; 7:157. PMID: 24062645; PMCID: PMC3774988.
    13. Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG. Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2239-48. PMID: 23729813; PMCID: PMC3683782.
    14. Viaro R, Calcagno M, Marti M, Borrelli E, Morari M. Pharmacological and genetic evidence for pre- and postsynaptic D2 receptor involvement in motor responses to nociceptin/orphanin FQ receptor ligands. Neuropharmacology. 2013 Sep; 72:126-38. PMID: 23643745.
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    15. Radl D, De Mei C, Chen E, Lee H, Borrelli E. Each individual isoform of the dopamine D2 receptor protects from lactotroph hyperplasia. Mol Endocrinol. 2013 Jun; 27(6):953-65. PMID: 23608643; PMCID: PMC3656237.
    16. Maheux J, St-Hilaire M, Voyer D, Tirotta E, Borrelli E, Rouillard C, Rompré PP, Lévesque D. Dopamine D(2) Antagonist-Induced Striatal Nur77 Expression Requires Activation of mGlu5 Receptors by Cortical Afferents. Front Pharmacol. 2012; 3:153. PMID: 22912617; PMCID: PMC3418524.
    17. Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci. 2012 Jun 27; 32(26):9023-34. PMID: 22745501; PMCID: PMC3752062.
    18. Park E, Iaccarino C, Lee J, Kwon I, Baik SM, Kim M, Seong JY, Son GH, Borrelli E, Kim K. Regulatory roles of heterogeneous nuclear ribonucleoprotein M and Nova-1 protein in alternative splicing of dopamine D2 receptor pre-mRNA. J Biol Chem. 2011 Jul 15; 286(28):25301-8. PMID: 21622564; PMCID: PMC3137101.
    19. Doretto S, Malerba M, Ramos M, Ikrar T, Kinoshita C, De Mei C, Tirotta E, Xu X, Borrelli E. Oligodendrocytes as regulators of neuronal networks during early postnatal development. PLoS One. 2011 May 12; 6(5):e19849. PMID: 21589880; PMCID: PMC3093406.
    20. Fulton S, Thibault D, Mendez JA, Lahaie N, Tirotta E, Borrelli E, Bouvier M, Tempel BL, Trudeau LE. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow. J Biol Chem. 2011 Mar 18; 286(11):9360-72. PMID: 21233214; PMCID: PMC3059064.
    21. Benoit-Marand M, Ballion B, Borrelli E, Boraud T, Gonon F. Inhibition of dopamine uptake by D2 antagonists: an in vivo study. J Neurochem. 2011 Feb; 116(3):449-58. PMID: 21128941.
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    22. Tripathi PP, Santorufo G, Brilli E, Borrelli E, Bozzi Y. Kainic acid-induced seizures activate GSK-3ß in the hippocampus of D2R-/- mice. Neuroreport. 2010 Aug 23; 21(12):846-50. PMID: 20625330.
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    23. Sahar S, Zocchi L, Kinoshita C, Borrelli E, Sassone-Corsi P. Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One. 2010 Jan 01; 5(1):e8561. PMID: 20049328; PMCID: PMC2797305.
    24. Bertolino A, Fazio L, Di Giorgio A, Blasi G, Romano R, Taurisano P, Caforio G, Sinibaldi L, Ursini G, Popolizio T, Tirotta E, Papp A, Dallapiccola B, Borrelli E, Sadee W. Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. J Neurosci. 2009 Jan 28; 29(4):1224-34. PMID: 19176830; PMCID: PMC2686116.
    25. De Mei C, Ramos M, Iitaka C, Borrelli E. Getting specialized: presynaptic and postsynaptic dopamine D2 receptors. Curr Opin Pharmacol. 2009 Feb; 9(1):53-8. PMID: 19138563; PMCID: PMC2710814.
    26. Borrelli E, Nestler EJ, Allis CD, Sassone-Corsi P. Decoding the epigenetic language of neuronal plasticity. Neuron. 2008 Dec 26; 60(6):961-74. PMID: 19109904; PMCID: PMC2737473.
    27. Tirotta E, Fontaine V, Picetti R, Lombardi M, Samad TA, Oulad-Abdelghani M, Edwards R, Borrelli E. Signaling by dopamine regulates D2 receptors trafficking at the membrane. Cell Cycle. 2008 Jul 15; 7(14):2241-8. PMID: 18635969.
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    28. Compe E, Malerba M, Soler L, Marescaux J, Borrelli E, Egly JM. Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci. 2007 Nov; 10(11):1414-22. PMID: 17952069.
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    29. Collin L, Doretto S, Malerba M, Ruat M, Borrelli E. Oligodendrocyte ablation affects the coordinated interaction between granule and Purkinje neurons during cerebellum development. Exp Cell Res. 2007 Aug 01; 313(13):2946-57. PMID: 17544395.
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    30. Welter M, Vallone D, Samad TA, Meziane H, Usiello A, Borrelli E. Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6840-5. PMID: 17426149; PMCID: PMC1871872.
    31. Beaulieu JM, Tirotta E, Sotnikova TD, Masri B, Salahpour A, Gainetdinov RR, Borrelli E, Caron MG. Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. J Neurosci. 2007 Jan 24; 27(4):881-5. PMID: 17251429.
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    32. Doi M, Yujnovsky I, Hirayama J, Malerba M, Tirotta E, Sassone-Corsi P, Borrelli E. Impaired light masking in dopamine D2 receptor-null mice. Nat Neurosci. 2006 Jun; 9(6):732-4. PMID: 16715079.
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    33. Yujnovsky I, Hirayama J, Doi M, Borrelli E, Sassone-Corsi P. Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6386-91. PMID: 16606840; PMCID: PMC1458887.
    34. Bozzi Y, Borrelli E. Dopamine in neurotoxicity and neuroprotection: what do D2 receptors have to do with it? Trends Neurosci. 2006 Mar; 29(3):167-74. PMID: 16443286.
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    35. Andersson M, Usiello A, Borgkvist A, Pozzi L, Dominguez C, Fienberg AA, Svenningsson P, Fredholm BB, Borrelli E, Greengard P, Fisone G. Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons. J Neurosci. 2005 Sep 14; 25(37):8432-8. PMID: 16162925.
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    36. Mansikka H, Erbs E, Borrelli E, Pertovaara A. Influence of the dopamine D2 receptor knockout on pain-related behavior in the mouse. Brain Res. 2005 Aug 02; 1052(1):82-7. PMID: 15996639.
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    37. Borrelli E. Emiliana Borrelli. Interview by Fiona Watt. J Cell Sci. 2005 Aug 01; 118(Pt 15):3223-4. PMID: 16079274.
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    38. Borrelli E. Without DJ-1, the D2 receptor doesn't play. Neuron. 2005 Feb 17; 45(4):479-81. PMID: 15721232.
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    39. Centonze D, Usiello A, Costa C, Picconi B, Erbs E, Bernardi G, Borrelli E, Calabresi P. Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors. J Neurosci. 2004 Sep 22; 24(38):8214-22. PMID: 15385604.
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    40. Vargas-Pérez H, Borrelli E, Díaz JL. Wheel running use in dopamine D2L receptor knockout mice. Neurosci Lett. 2004 Aug 12; 366(2):172-5. PMID: 15276241.
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    41. Håkansson K, Pozzi L, Usiello A, Haycock J, Borrelli E, Fisone G. Regulation of striatal tyrosine hydroxylase phosphorylation by acute and chronic haloperidol. Eur J Neurosci. 2004 Aug; 20(4):1108-12. PMID: 15305880.
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    42. Kobayashi M, Iaccarino C, Saiardi A, Heidt V, Bozzi Y, Picetti R, Vitale C, Westphal H, Drago J, Borrelli E. Simultaneous absence of dopamine D1 and D2 receptor-mediated signaling is lethal in mice. Proc Natl Acad Sci U S A. 2004 Aug 03; 101(31):11465-70. PMID: 15272078; PMCID: PMC509223.
    43. Kitchener P, Di Blasi F, Borrelli E, Piazza PV. Differences between brain structures in nuclear translocation and DNA binding of the glucocorticoid receptor during stress and the circadian cycle. Eur J Neurosci. 2004 Apr; 19(7):1837-46. PMID: 15078557.
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    44. An JJ, Bae MH, Cho SR, Lee SH, Choi SH, Lee BH, Shin HS, Kim YN, Park KW, Borrelli E, Baik JH. Altered GABAergic neurotransmission in mice lacking dopamine D2 receptors. Mol Cell Neurosci. 2004 Apr; 25(4):732-41. PMID: 15080900.
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    45. Collin L, Usiello A, Erbs E, Mathis C, Borrelli E. Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):325-30. PMID: 14694200; PMCID: PMC314184.
    46. Crosio C, Heitz E, Allis CD, Borrelli E, Sassone-Corsi P. Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons. J Cell Sci. 2003 Dec 15; 116(Pt 24):4905-14. PMID: 14625384.
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    47. Mathis C, Collin L, Borrelli E. Oligodendrocyte ablation impairs cerebellum development. Development. 2003 Oct; 130(19):4709-18. PMID: 12925596.
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    48. Centonze D, Grande C, Usiello A, Gubellini P, Erbs E, Martin AB, Pisani A, Tognazzi N, Bernardi G, Moratalla R, Borrelli E, Calabresi P. Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons. J Neurosci. 2003 Jul 16; 23(15):6245-54. PMID: 12867509.
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    49. Lindgren N, Usiello A, Goiny M, Haycock J, Erbs E, Greengard P, Hokfelt T, Borrelli E, Fisone G. Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4305-9. PMID: 12651945; PMCID: PMC153088.
    50. Tan S, Hermann B, Borrelli E. Dopaminergic mouse mutants: investigating the roles of the different dopamine receptor subtypes and the dopamine transporter. Int Rev Neurobiol. 2003; 54:145-97. PMID: 12785287.
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    51. Centonze D, Usiello A, Gubellini P, Pisani A, Borrelli E, Bernardi G, Calabresi P. Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors. Neuropsychopharmacology. 2002 Nov; 27(5):723-6. PMID: 12431847.
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    52. Iaccarino C, Samad TA, Mathis C, Kercret H, Picetti R, Borrelli E. Control of lactotrop proliferation by dopamine: essential role of signaling through D2 receptors and ERKs. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14530-5. PMID: 12391292; PMCID: PMC137917.
    53. Rouge-Pont F, Usiello A, Benoit-Marand M, Gonon F, Piazza PV, Borrelli E. Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors. J Neurosci. 2002 Apr 15; 22(8):3293-301. PMID: 11943831.
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    54. Caine SB, Negus SS, Mello NK, Patel S, Bristow L, Kulagowski J, Vallone D, Saiardi A, Borrelli E. Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. J Neurosci. 2002 Apr 01; 22(7):2977-88. PMID: 11923462.
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    55. Centonze D, Picconi B, Baunez C, Borrelli E, Pisani A, Bernardi G, Calabresi P. Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors. Neuropsychopharmacology. 2002 Feb; 26(2):164-75. PMID: 11790512.
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    56. Bozzi Y, Borrelli E. Dopamine D2 receptor signaling controls neuronal cell death induced by muscarinic and glutamatergic drugs. Mol Cell Neurosci. 2002 Feb; 19(2):263-71. PMID: 11860278.
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