Shi, Yongsheng

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentMicrobiology and Molecular Biology & Biochemistryar Genetics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-0358
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    Collapse Research 
    Collapse Research Activities and Funding
    Herpes simplex virus-mediated regulation of host gene expression
    NIH/NIGMS R01GM128441May 1, 2018 - Mar 31, 2022
    Role: Principal Investigator
    Coordinated regulation of alternative pre-mRNA processing in colon cancer
    NIH/NCI R01CA177651May 1, 2014 - Apr 30, 2019
    Role: Co-Principal Investigator
    Characterization of the mammalian mRNA-3'-end processing complex
    NIH/NIGMS R01GM090056Mar 15, 2010 - Apr 30, 2019
    Role: Principal Investigator
    Phosphorylation regulation of SRp38 by cell signaling
    NIH/NIGMS F32GM070113May 1, 2004 - Apr 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhu Y, Wang X, Forouzmand E, Jeong J, Qiao F, Sowd GA, Engelman AN, Xie X, Hertel KJ, Shi Y. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Mol Cell. 2018 Jan 04; 69(1):62-74.e4. PMID: 29276085.
      View in: PubMed
    2. Wang X, Shi Y. Purification of mRNA Processing Complexes Using an RNA Affinity Approach. Methods Mol Biol. 2017; 1648:53-63. PMID: 28766289.
      View in: PubMed
    3. Movassat M, Crabb TL, Busch A, Yao C, Reynolds DJ, Shi Y, Hertel KJ. Coupling between alternative polyadenylation and alternative splicing is limited to terminal introns. RNA Biol. 2016 07 02; 13(7):646-55. PMID: 27245359; PMCID: PMC4962795 [Available on 05/31/17].
    4. Weng L, Li Y, Xie X, Shi Y. Poly(A) code analyses reveal key determinants for tissue-specific mRNA alternative polyadenylation. RNA. 2016 06; 22(6):813-21. PMID: 27095026; PMCID: PMC4878608 [Available on 06/01/17].
    5. Shi Y, Manley JL. The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation site. Genes Dev. 2015 May 01; 29(9):889-97. PMID: 25934501; PMCID: PMC4421977.
    6. Shi Y. Two decades of RNA as I see it. RNA. 2015 Apr; 21(4):733-4. PMID: 25780213; PMCID: PMC4371355.
    7. Chan SL, Huppertz I, Yao C, Weng L, Moresco JJ, Yates JR, Ule J, Manley JL, Shi Y. CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing. Genes Dev. 2014 Nov 01; 28(21):2370-80. PMID: 25301780.
      View in: PubMed
    8. Davis R, Shi Y. The polyadenylation code: a unified model for the regulation of mRNA alternative polyadenylation. J Zhejiang Univ Sci B. 2014 May; 15(5):429-37. PMID: 24793760; PMCID: PMC4076599.
    9. Yao C, Weng L, Shi Y. Global protein-RNA interaction mapping at single nucleotide resolution by iCLIP-seq. Methods Mol Biol. 2014; 1126:399-410. PMID: 24549678; PMCID: PMC4412157.
    10. Yao C, Shi Y. Global and quantitative profiling of polyadenylated RNAs using PAS-seq. Methods Mol Biol. 2014; 1125:179-85. PMID: 24590790; PMCID: PMC4412162.
    11. Yao C, Biesinger J, Wan J, Weng L, Xing Y, Xie X, Shi Y. Transcriptome-wide analyses of CstF64-RNA interactions in global regulation of mRNA alternative polyadenylation. Proc Natl Acad Sci U S A. 2012 Nov 13; 109(46):18773-8. PMID: 23112178; PMCID: PMC3503179.
    12. Shi Y. Alternative polyadenylation: new insights from global analyses. RNA. 2012 Dec; 18(12):2105-17. PMID: 23097429; PMCID: PMC3504663.
    13. Shepard PJ, Choi EA, Lu J, Flanagan LA, Hertel KJ, Shi Y. Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq. RNA. 2011 Apr; 17(4):761-72. PMID: 21343387; PMCID: PMC3062186.
    14. Chan S, Choi EA, Shi Y. Pre-mRNA 3'-end processing complex assembly and function. Wiley Interdiscip Rev RNA. 2011 May-Jun; 2(3):321-35. PMID: 21957020; PMCID: PMC3980678.
    15. Shi Y, Chan S, Martinez-SantibaƱez G. An up-close look at the pre-mRNA 3'-end processing complex. RNA Biol. 2009 Nov-Dec; 6(5):522-5. PMID: 19713761.
      View in: PubMed
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