Kai Kessenbrock

Title(s)Associate Professor, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2718
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    Collapse Research 
    Collapse Research Activities and Funding
    Microenvironmental regulation of breast tumorigenesis
    NIH R01CA234496Feb 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Proteolytic regulation of Wnt signaling in breast cancer stem cells
    NIH R00CA181490Aug 6, 2014 - Nov 30, 2019
    Role: Principal Investigator
    Proteolytic regulation of Wnt signaling in breast cancer stem cells
    NIH K99CA181490Aug 6, 2014 - Jul 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication. Cell Rep. 2022 08 02; 40(5):111155. Vu R, Jin S, Sun P, Haensel D, Nguyen QH, Dragan M, Kessenbrock K, Nie Q, Dai X. PMID: 35926463.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    2. scEpiLock: A Weakly Supervised Learning Framework for cis-Regulatory Element Localization and Variant Impact Quantification for Single-Cell Epigenetic Data. Biomolecules. 2022 06 23; 12(7). Gong Y, Srinivasan SS, Zhang R, Kessenbrock K, Zhang J. PMID: 35883430; PMCID: PMC9312957.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Author Correction: Automated segmentation and tracking of mitochondria in live-cell time-lapse images. Nat Methods. 2022 Jun; 19(6):770. Lefebvre AEYT, Ma D, Kessenbrock K, Lawson DA, Digman MA. PMID: 35487982.
      View in: PubMed   Mentions:    Fields:    
    4. Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1. Cell Rep. 2022 01 11; 38(2):110240. Han Y, Villarreal-Ponce A, Gutierrez G, Nguyen Q, Sun P, Wu T, Sui B, Berx G, Brabletz T, Kessenbrock K, Zeng YA, Watanabe K, Dai X. PMID: 35021086; PMCID: PMC9894649.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    5. Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis. Commun Biol. 2021 11 05; 4(1):1268. Ma D, Hernandez GA, Lefebvre AEYT, Alshetaiwi H, Blake K, Dave KR, Rauf M, Williams JW, Davis RT, Evans KT, Longworth A, Masoud MYG, Lee R, Edwards RA, Digman MA, Kessenbrock K, Lawson DA. PMID: 34741115; PMCID: PMC8571269.
      View in: PubMed   Mentions: 1  Translation:Animals
    6. Evidence for accelerated aging in mammary epithelia of women carrying germline BRCA1 or BRCA2 mutations. Nat Aging. 2021 Sep; 1(9):838-849. Shalabi SF, Miyano M, Sayaman RW, Lopez JC, Jokela TA, Todhunter ME, Hinz S, Garbe JC, Stampfer MR, Kessenbrock K, Seewaldt VE, LaBarge MA. PMID: 35187501; PMCID: PMC8849557.
      View in: PubMed   Mentions: 2  
    7. Automated segmentation and tracking of mitochondria in live-cell time-lapse images. Nat Methods. 2021 09; 18(9):1091-1102. Lefebvre AEYT, Ma D, Kessenbrock K, Lawson DA, Digman MA. PMID: 34413523.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    8. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 06 03; 4(1):685. Mohammadi MR, Rodriguez SM, Luong JC, Li S, Cao R, Alshetaiwi H, Lau H, Davtyan H, Jones MB, Jafari M, Kessenbrock K, Villalta SA, de Vos P, Zhao W, Lakey JRT. PMID: 34083739; PMCID: PMC8175379.
      View in: PubMed   Mentions: 5  Translation:HumansAnimalsCells
    9. Let-7f miRNA regulates SDF-1a- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release. Cell Death Dis. 2021 05 20; 12(6):516. Egea V, Kessenbrock K, Lawson D, Bartelt A, Weber C, Ries C. PMID: 34016957; PMCID: PMC8137693.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Microfluidic platform accelerates tissue processing into single cells for molecular analysis and primary culture models. Nat Commun. 2021 05 17; 12(1):2858. Lombardo JA, Aliaghaei M, Nguyen QH, Kessenbrock K, Haun JB. PMID: 34001902; PMCID: PMC8128882.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    11. An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Lab Chip. 2021 04 07; 21(7):1333-1351. Hachey SJ, Movsesyan S, Nguyen QH, Burton-Sojo G, Tankazyan A, Wu J, Hoang T, Zhao D, Wang S, Hatch MM, Celaya E, Gomez S, Chen GT, Davis RT, Nee K, Pervolarakis N, Lawson DA, Kessenbrock K, Lee AP, Lowengrub J, Waterman ML, Hughes CCW. PMID: 33605955; PMCID: PMC8525497.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    12. Single-Cell Transcriptome Analysis Workflow for Splenic Myeloid-Derived Suppressor Cells from Murine Breast Cancer Models. Methods Mol Biol. 2021; 2236:177-187. Alshetaiwi H, Pervolarakis N, Nguyen QH, Kessenbrock K. PMID: 33237548; PMCID: PMC9159675.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia. J Invest Dermatol. 2021 06; 141(6):1542-1552. Sun P, Vu R, Dragan M, Haensel D, Gutierrez G, Nguyen Q, Greenberg E, Chen Z, Wu J, Atwood S, Pearlman E, Shi Y, Han W, Kessenbrock K, Dai X. PMID: 33333123; PMCID: PMC8532526.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Integrated Single-Cell Transcriptomics and Chromatin Accessibility Analysis Reveals Regulators of Mammary Epithelial Cell Identity. Cell Rep. 2020 10 20; 33(3):108273. Pervolarakis N, Nguyen QH, Williams J, Gong Y, Gutierrez G, Sun P, Jhutty D, Zheng GXY, Nemec CM, Dai X, Watanabe K, Kessenbrock K. PMID: 33086071; PMCID: PMC7874899.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics. Cell Rep. 2020 03 17; 30(11):3932-3947.e6. Haensel D, Jin S, Sun P, Cinco R, Dragan M, Nguyen Q, Cang Z, Gong Y, Vu R, MacLean AL, Kessenbrock K, Gratton E, Nie Q, Dai X. PMID: 32187560; PMCID: PMC7218802.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    16. Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics. Sci Immunol. 2020 02 21; 5(44). Alshetaiwi H, Pervolarakis N, McIntyre LL, Ma D, Nguyen Q, Rath JA, Nee K, Hernandez G, Evans K, Torosian L, Silva A, Walsh C, Kessenbrock K. PMID: 32086381; PMCID: PMC7219211.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    17. Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. Cancers (Basel). 2019 Sep 24; 11(10). Samocha A, Doh H, Kessenbrock K, Roose JP. PMID: 31554261; PMCID: PMC6826786.
      View in: PubMed   Mentions: 2  
    18. Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome. Commun Biol. 2019; 2:306. Chen W, Morabito SJ, Kessenbrock K, Enver T, Meyer KB, Teschendorff AE. PMID: 31428694; PMCID: PMC6689007.
      View in: PubMed   Mentions: 23  Translation:HumansCells
    19. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nat Commun. 2019 02 08; 10(1):650. Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV. PMID: 30737373; PMCID: PMC6368572.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    20. Tumour heterogeneity and metastasis at single-cell resolution. Nat Cell Biol. 2018 12; 20(12):1349-1360. Lawson DA, Kessenbrock K, Davis RT, Pervolarakis N, Werb Z. PMID: 30482943; PMCID: PMC6477686.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansCells
    21. Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip. 2018 09 11; 18(18):2776-2786. Qiu X, Lombardo JA, Westerhof TM, Pennell M, Ng A, Alshetaiwi H, Luna BM, Nelson EL, Kessenbrock K, Hui EE, Haun JB. PMID: 30090895; PMCID: PMC6171522.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. Experimental Considerations for Single-Cell RNA Sequencing Approaches. Front Cell Dev Biol. 2018; 6:108. Nguyen QH, Pervolarakis N, Nee K, Kessenbrock K. PMID: 30234113; PMCID: PMC6131190.
      View in: PubMed   Mentions: 67  
    23. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 05 23; 9(1):2028. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. PMID: 29795293; PMCID: PMC5966421.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    24. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018 02 01; 32(3-4):244-257. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. PMID: 29483153; PMCID: PMC5859966.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    25. Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3121-3126. Kessenbrock K, Smith P, Steenbeek SC, Pervolarakis N, Kumar R, Minami Y, Goga A, Hinck L, Werb Z. PMID: 28270600; PMCID: PMC5373387.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    26. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PMID: 27775705; PMCID: PMC5341692.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    27. Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps. Sci Transl Med. 2016 10 19; 8(361):361ra138. Park J, Wysocki RW, Amoozgar Z, Maiorino L, Fein MR, Jorns J, Schott AF, Kinugasa-Katayama Y, Lee Y, Won NH, Nakasone ES, Hearn SA, K?ttner V, Qiu J, Almeida AS, Perurena N, Kessenbrock K, Goldberg MS, Egeblad M. PMID: 27798263; PMCID: PMC5550900.
      View in: PubMed   Mentions: 334     Fields:    Translation:HumansAnimalsCells
    28. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. PMID: 26416748; PMCID: PMC4648562.
      View in: PubMed   Mentions: 403     Fields:    Translation:HumansAnimalsCells
    29. Matrix metalloproteinases in stem cell regulation and cancer. Matrix Biol. 2015 May-Jul; 44-46:184-90. Kessenbrock K, Wang CY, Werb Z. PMID: 25661772; PMCID: PMC4498798.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    30. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 05; 13(3):300-13. Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. PMID: 23871604; PMCID: PMC3769456.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    31. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. J Clin Invest. 2012 Jul; 122(7):2661-71. Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR. PMID: 22684106; PMCID: PMC3386815.
      View in: PubMed   Mentions: 460     Fields:    Translation:HumansAnimalsCells
    32. Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes. Curr Protoc Immunol. 2011 Apr; Chapter 14:Unit14.24. Kessenbrock K, Brown M, Werb Z. PMID: 21462166; PMCID: PMC3538162.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    33. Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response. J Mol Med (Berl). 2011 Jan; 89(1):23-8. Kessenbrock K, Dau T, Jenne DE. PMID: 20809089; PMCID: PMC3016231.
      View in: PubMed   Mentions: 39     Fields:    Translation:Cells
    34. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell. 2010 Apr 02; 141(1):52-67. Kessenbrock K, Plaks V, Werb Z. PMID: 20371345; PMCID: PMC2862057.
      View in: PubMed   Mentions: 1936     Fields:    Translation:HumansAnimals
    35. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009 Jun; 15(6):623-5. Kessenbrock K, Krumbholz M, Schönermarck U, Back W, Gross WL, Werb Z, Gröne HJ, Brinkmann V, Jenne DE. PMID: 19448636; PMCID: PMC2760083.
      View in: PubMed   Mentions: 693     Fields:    Translation:Cells
    36. Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin. J Clin Invest. 2008 Jul; 118(7):2438-47. Kessenbrock K, Fröhlich L, Sixt M, Lämmermann T, Pfister H, Bateman A, Belaaouaj A, Ring J, Ollert M, Fässler R, Jenne DE. PMID: 18568075; PMCID: PMC2430496.
      View in: PubMed   Mentions: 185     Fields:    Translation:AnimalsCells
    37. Lifeact: a versatile marker to visualize F-actin. Nat Methods. 2008 Jul; 5(7):605-7. Riedl J, Crevenna AH, Kessenbrock K, Yu JH, Neukirchen D, Bista M, Bradke F, Jenne D, Holak TA, Werb Z, Sixt M, Wedlich-Soldner R. PMID: 18536722; PMCID: PMC2814344.
      View in: PubMed   Mentions: 1076     Fields:    Translation:HumansAnimalsCells
    38. Diverse humoral autoimmunity to the ribosomal P proteins in systemic lupus erythematosus and hepatitis C virus infection. J Mol Med (Berl). 2007 Sep; 85(9):953-9. Kessenbrock K, Fritzler MJ, Groves M, Eissfeller P, von Mühlen CA, Höpfl P, Mahler M. PMID: 17668158.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. Synthetic peptides: the future of patient management in systemic rheumatic diseases? Curr Med Chem. 2007; 14(26):2831-8. Kessenbrock K, Raijmakers R, Fritzler MJ, Mahler M. PMID: 18045129.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    40. International multicenter evaluation of autoantibodies to ribosomal P proteins. Clin Vaccine Immunol. 2006 Jan; 13(1):77-83. Mahler M, Kessenbrock K, Szmyrka M, Takasaki Y, Garcia-De La Torre I, Shoenfeld Y, Hiepe F, Shun-le C, von Mühlen CA, Locht H, Höpfl P, Wiik A, Reeves W, Fritzler MJ. PMID: 16426003; PMCID: PMC1356623.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    41. Technical and clinical evaluation of anti-ribosomal P protein immunoassays. J Clin Lab Anal. 2004; 18(4):215-23. Mahler M, Kessenbrock K, Raats J, Fritzler MJ. PMID: 15202113; PMCID: PMC6807712.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    42. Characterization of the human autoimmune response to the major C-terminal epitope of the ribosomal P proteins. J Mol Med (Berl). 2003 Mar; 81(3):194-204. Mahler M, Kessenbrock K, Raats J, Williams R, Fritzler MJ, Blüthner M. PMID: 12682728.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
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