Roberto Tinoco

Title(s)Assistant Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address3120 McGaugh Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-4926
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. HMGB2 regulates the differentiation and stemness of exhausted CD8+ T cells during chronic viral infection and cancer. Nat Commun. 2023 09 13; 14(1):5631. Neubert EN, DeRogatis JM, Lewis SA, Viramontes KM, Ortega P, Henriquez ML, Buisson R, Messaoudi I, Tinoco R. PMID: 37704621; PMCID: PMC10499904.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    2. PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion. Cell Rep. 2023 05 30; 42(5):112436. Hope JL, Otero DC, Bae EA, Stairiker CJ, Palete AB, Faso HA, Lin M, Henriquez ML, Roy S, Seo H, Lei X, Wang ES, Chow S, Tinoco R, Daniels GA, Yip K, Campos AR, Yin J, Adams PD, Rao A, Bradley LM. PMID: 37115668; PMCID: PMC10403047.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    3. Cell-Intrinsic CD38 Expression Sustains Exhausted CD8+ T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection. J Virol. 2023 04 27; 97(4):e0022523. DeRogatis JM, Neubert EN, Viramontes KM, Henriquez ML, Nicholas DA, Tinoco R. PMID: 37039663; PMCID: PMC10134879.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    4. PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells. Front Immunol. 2022; 13:869768. Viramontes KM, Neubert EN, DeRogatis JM, Tinoco R. PMID: 35774790; PMCID: PMC9237324.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Targeting the PSGL-1 Immune Checkpoint Promotes Immunity to PD-1-Resistant Melanoma. Cancer Immunol Res. 2022 05 03; 10(5):612-625. DeRogatis JM, Viramontes KM, Neubert EN, Henriquez ML, Guerrero-Juarez CF, Tinoco R. PMID: 35303066; PMCID: PMC9064985.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    6. The cure from within? a review of the microbiome and diet in melanoma. Cancer Metastasis Rev. 2022 06; 41(2):261-280. Kumar P, Brazel D, DeRogatis J, Valerin JBG, Whiteson K, Chow WA, Tinoco R, Moyers JT. PMID: 35474500; PMCID: PMC9042647.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    7. PSGL-1 Is a T Cell Intrinsic Inhibitor That Regulates Effector and Memory Differentiation and Responses During Viral Infection. Front Immunol. 2021; 12:677824. Tinoco R, Neubert EN, Stairiker CJ, Henriquez ML, Bradley LM. PMID: 34326837; PMCID: PMC8314012.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. PSGL-1 Immune Checkpoint Inhibition for CD4+ T Cell Cancer Immunotherapy. Front Immunol. 2021; 12:636238. DeRogatis JM, Viramontes KM, Neubert EN, Tinoco R. PMID: 33708224; PMCID: PMC7940186.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    9. Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth. Cell Rep. 2020 02 11; 30(6):1753-1766.e6. Li Y, Elmén L, Segota I, Xian Y, Tinoco R, Feng Y, Fujita Y, Segura Muñoz RR, Schmaltz R, Bradley LM, Ramer-Tait A, Zarecki R, Long T, Peterson SN, Ronai ZA. PMID: 32049008; PMCID: PMC7053418.
      View in: PubMed   Mentions: 68     Fields:    Translation:Animals
    10. Siah2 control of T-regulatory cells limits anti-tumor immunity. Nat Commun. 2020 01 07; 11(1):99. Scortegagna M, Hockemeyer K, Dolgalev I, Pozniak J, Rambow F, Li Y, Feng Y, Tinoco R, Otero DC, Zhang T, Brown K, Bosenberg M, Bradley LM, Marine JC, Aifantis I, Ronai ZA. PMID: 31911617; PMCID: PMC6946684.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice. Nat Commun. 2019 04 02; 10(1):1492. Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA. PMID: 30940817; PMCID: PMC6445090.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    12. Ubiquitin Ligases in Cancer Immunotherapy - Balancing Antitumor and Autoimmunity. Trends Mol Med. 2019 05; 25(5):428-443. Fujita Y, Tinoco R, Li Y, Senft D, Ronai ZA. PMID: 30898473; PMCID: PMC6488401.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    13. Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis. Cell Rep. 2018 09 18; 24(12):3296-3311.e6. Fujita Y, Khateb A, Li Y, Tinoco R, Zhang T, Bar-Yoseph H, Tam MA, Chowers Y, Sabo E, Gerassy-Vainberg S, Starosvetsky E, James B, Brown K, Shen-Orr SS, Bradley LM, Tessier PA, Ronai ZA. PMID: 30232010; PMCID: PMC6185744.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    14. Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Nat Immunol. 2018 06; 19(6):594-605. Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley LM, D'Angelo MA. PMID: 29736031; PMCID: PMC5976539.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells. J Immunol. 2018 04 15; 200(8):2690-2702. Tinoco R, Carrette F, Henriquez ML, Fujita Y, Bradley LM. PMID: 29491007; PMCID: PMC5890537.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    16. Targeting the PSGL-1 pathway for immune modulation. Immunotherapy. 2017 09; 9(10):785-788. Tinoco R, Bradley LM. PMID: 28877633; PMCID: PMC5618955.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    17. PSGL-1: A New Player in the Immune Checkpoint Landscape. Trends Immunol. 2017 05; 38(5):323-335. Tinoco R, Otero DC, Takahashi AA, Bradley LM. PMID: 28262471; PMCID: PMC5411281.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    18. PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. Immunity. 2016 Jun 21; 44(6):1470. Tinoco R, Carrette F, Barraza ML, Otero DC, Magaña J, Bosenberg MW, Swain SL, Bradley LM. PMID: 27332735.
      View in: PubMed   Mentions: 20     Fields:    
    19. PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. Immunity. 2016 05 17; 44(5):1190-203. Tinoco R, Carrette F, Barraza ML, Otero DC, Magaña J, Bosenberg MW, Swain SL, Bradley LM. PMID: 27192578; PMCID: PMC4908967.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    20. Regulation of Antigen-Experienced T Cells: Lessons from the Quintessential Memory Marker CD44. Front Immunol. 2012; 3:23. Baaten BJ, Tinoco R, Chen AT, Bradley LM. PMID: 22566907; PMCID: PMC3342067.
      View in: PubMed   Mentions: 67     Fields:    
    21. Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity. 2009 Jul 17; 31(1):145-57. Tinoco R, Alcalde V, Yang Y, Sauer K, Zuniga EI. PMID: 19604493; PMCID: PMC3039716.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    22. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009 Feb; 10(2):176-84. Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM. PMID: 19136962; PMCID: PMC2856471.
      View in: PubMed   Mentions: 307     Fields:    Translation:AnimalsCells
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