MacGregor, Grant R

InstitutionUniversity of California, Irvine
DepartmentDevelopmental & Cell Biology
Address4213 McGaugh Hall
Zot 2275
CA 92697
Phone(949) 824-8253, 4728
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    Collapse Research 
    Collapse Research Activities and Funding
    Function of FNDC3B in cardiovascular and pulmonary development
    NIH/NHLBI R21HL102862Apr 1, 2010 - Mar 31, 2013
    Role: Principal Investigator
    A Novel Gene Required for Sertoli-Spermatids Adhesion
    NIH/NICHD U01HD045913Dec 1, 2003 - Nov 30, 2009
    Role: Principal Investigator
    NIH/NICHD R01HD036437May 15, 1998 - Jun 30, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Fonseca MI, Chu SH, Hernandez MX, Fang MJ, Modarresi L, Selvan P, MacGregor G, Tenner AJ. Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain. J Neuroinflammation. 2017 Mar 06; 14(1):48. PMID: 28264694.
      View in: PubMed
    2. Kokoszka JE, Waymire KG, Flierl A, Sweeney KM, Angelin A, MacGregor G, Wallace DC. Deficiency in the mouse mitochondrial adenine nucleotide translocator isoform 2 gene is associated with cardiac noncompaction. Biochim Biophys Acta. 2016 Aug; 1857(8):1203-1212. PMID: 27048932.
      View in: PubMed
    3. Paterson EK, Fielder TJ, MacGregor G, Ito S, Wakamatsu K, Gillen DL, Eby V, Boissy RE, Ganesan AK. Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle. PLoS One. 2015; 10(11):e0143702. PMID: 26619124; PMCID: PMC4664286.
    4. Oh JW, Chung O, Cho YS, MacGregor G, Plikus MV. Gene loss in keratinization programs accompanies adaptation of cetacean skin to aquatic lifestyle. Exp Dermatol. 2015 Aug; 24(8):572-3. PMID: 25959646; PMCID: PMC4520764.
    5. Reyes de Mochel NS, Luong M, Chiang M, Javier AL, Luu E, Toshihiko F, MacGregor G, Cinquin O, Cho KW. BMP signaling is required for cell cleavage in preimplantation-mouse embryos. Dev Biol. 2015 Jan 01; 397(1):45-55. PMID: 25446538; PMCID: PMC4309750.
    6. Lin CS, Sharpley MS, Fan W, Waymire KG, Sadun AA, Carelli V, Ross-Cisneros FN, Baciu P, Sung E, McManus MJ, Pan BX, Gil DW, Macgregor GR, Wallace DC. Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):20065-70. PMID: 23129651; PMCID: PMC3523873.
    7. Sharpley MS, Marciniak C, Eckel-Mahan K, McManus M, Crimi M, Waymire K, Lin CS, Masubuchi S, Friend N, Koike M, Chalkia D, MacGregor G, Sassone-Corsi P, Wallace DC. Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition. Cell. 2012 Oct 12; 151(2):333-343. PMID: 23063123; PMCID: PMC4175720.
    8. Fielder TJ, Yi CS, Masumi J, Waymire KG, Chen HW, Wang S, Shi KX, Wallace DC, MacGregor G. Comparison of male chimeric mice generated from microinjection of JM8.N4 embryonic stem cells into C57BL/6J and C57BL/6NTac blastocysts. Transgenic Res. 2012 Dec; 21(6):1149-58. PMID: 22422470; PMCID: PMC3445772.
    9. Navarro SJ, Trinh T, Lucas CA, Ross AJ, Waymire KG, Macgregor GR. The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2. G3 (Bethesda). 2012 Jan; 2(1):99-102. PMID: 22384386; PMCID: PMC3276190.
    10. Strong MK, Southwell AL, Yonan JM, Hayden MR, Macgregor GR, Thompson LM, Steward O. Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background. J Huntingtons Dis. 2012; 1(2):221-41. PMID: 23833693; PMCID: PMC3702054.
    11. Nicholson A, Reifsnyder PC, Malcolm RD, Lucas CA, MacGregor G, Zhang W, Leiter EH. Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) gene. Obesity (Silver Spring). 2010 Oct; 18(10):1902-5. PMID: 20057372; PMCID: PMC2888716.
    12. Ikegami K, Horigome D, Mukai M, Livnat I, MacGregor G, Setou M. TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1. FEBS Lett. 2008 Apr 02; 582(7):1129-34. PMID: 18331838; PMCID: PMC2408875.
    13. Fan W, Waymire KG, Narula N, Li P, Rocher C, Coskun PE, Vannan MA, Narula J, Macgregor GR, Wallace DC. A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations. Science. 2008 Feb 15; 319(5865):958-62. PMID: 18276892; PMCID: PMC3049809.
    14. Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T, Morone N, Yuasa S, Inokuchi K, Ohtsuka T, Macgregor GR, Tanaka K, Setou M. SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell. 2007 Sep 07; 130(5):943-57. PMID: 17803915; PMCID: PMC3049808.
    15. Ikegami K, Heier RL, Taruishi M, Takagi H, Mukai M, Shimma S, Taira S, Hatanaka K, Morone N, Yao I, Campbell PK, Yuasa S, Janke C, Macgregor GR, Setou M. Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3213-8. PMID: 17360631; PMCID: PMC1802010.
    16. Ikegami K, Mukai M, Tsuchida J, Heier RL, Macgregor GR, Setou M. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites. J Biol Chem. 2006 Oct 13; 281(41):30707-16. PMID: 16901895; PMCID: PMC3049811.
    17. Obholz KL, Akopyan A, Waymire KG, MacGregor G. FNDC3A is required for adhesion between spermatids and Sertoli cells. Dev Biol. 2006 Oct 15; 298(2):498-513. PMID: 16904100; PMCID: PMC3049804.
    18. Kokoszka JE, Waymire KG, Levy SE, Sligh JE, Cai J, Jones DP, MacGregor G, Wallace DC. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature. 2004 Jan 29; 427(6973):461-5. PMID: 14749836; PMCID: PMC3049806.
    19. Campbell PK, Waymire KG, Heier RL, Sharer C, Day DE, Reimann H, Jaje JM, Friedrich GA, Burmeister M, Bartness TJ, Russell LD, Young LJ, Zimmer M, Jenne DE, MacGregor G. Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice. Genetics. 2002 Sep; 162(1):307-20. PMID: 12242242; PMCID: PMC1462267.
    20. MacGregor G. An extreme bias in the germ line of XY C57BL/6<->XY FVB/N chimaeric mice. Reproduction. 2002 Sep; 124(3):377-86. PMID: 12201811; PMCID: PMC3049803.
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