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Marian L Waterman

Title(s)Professor, Microbiology and Molecular Genetics
Phone(949) 824-2885, 3096
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    Collapse Research 
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    Therapeutic targeting of Wnt & Metabolism in Colon Cancer
    NIH/NCI R03CA223929Apr 3, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Complexity, Cooperation and Community in Cancer
    NIH/NCI U54CA217378Apr 1, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    A Short Course in Cancer Systems Biology
    NIH/NCI R25CA214654Sep 18, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Coordinated regulation of alternative pre-mRNA processing in colon cancer
    NIH/NCI R01CA177651May 1, 2014 - Apr 30, 2019
    Role: Co-Principal Investigator
    TCF3: A Wnt Pathway Effector in Pluripotent Stem Cell Self-Renewal
    NIH/NIGMS R01GM096017Sep 10, 2013 - Aug 31, 2018
    Role: Co-Principal Investigator
    A 3-D In Vitro Platform of Tumor Metastasis (PQ24)
    NIH/NCI R01CA170879Aug 20, 2012 - Jun 30, 2016
    Role: Co-Principal Investigator
    LEF-1 translation in chronic myelegenous leukemia
    NIH/NCI R21CA133275Aug 10, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Wnt Signaling in Colon Cancer
    NIH/NCI R01CA108697Jul 1, 2004 - Mar 31, 2016
    Role: Principal Investigator
    LEF/TCF Expression in colon cancer
    NIH/NCI R01CA096878Jul 1, 2002 - Apr 30, 2014
    Role: Principal Investigator
    ACTIVITIES OF BETA CATENIN AND LEF/TCF COMPLEXES
    NIH/NCI R01CA083982Jan 7, 2000 - Dec 31, 2005
    Role: Principal Investigator
    CONTROL OF T CELL RECEPTOR ALPHA CHAIN GENE EXPRESSION
    NIH/NCI R01CA062079Jul 1, 1994 - Apr 30, 2000
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, Greenhough A, Davies S, Williams AC, Blair A, Waterman ML, Tonks A, Darley RL. LEF-1 drives aberrant ß-catenin nuclear localization in myeloid leukemia cells. Haematologica. 2019 Jul; 104(7):1365-1377. PMID: 30630973.
      View in: PubMed
    2. Sierra RA, Hoverter NP, Ramirez RN, Vuong LM, Mortazavi A, Merrill BJ, Waterman ML, Donovan PJ. TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency. Development. 2018 02 23; 145(4). PMID: 29361574.
      View in: PubMed
    3. Lyou Y, Habowski AN, Chen GT, Waterman ML. Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy. Br J Pharmacol. 2017 Dec; 174(24):4589-4599. PMID: 28752891.
      View in: PubMed
    4. Lee M, Chen GT, Puttock E, Wang K, Edwards RA, Waterman ML, Lowengrub J. Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol. 2017 02 09; 13(2):912. PMID: 28183841.
      View in: PubMed
    5. Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML. Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab. 2016; 4:20. PMID: 27729975.
      View in: PubMed
    6. Chen GT, Waterman ML. Cancer: leaping the E-cadherin hurdle. EMBO J. 2015 Sep 14; 34(18):2307-9. PMID: 26282791.
      View in: PubMed
    7. Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM. Differential Effects of Hepatocyte Nuclear Factor 4a Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. Mol Cell Biol. 2015 Oct; 35(20):3471-90. PMID: 26240283.
      View in: PubMed
    8. Kurimoto S, Jung J, Tapadia M, Lengfeld J, Agalliu D, Waterman M, Mozaffar T, Gupta R. Activation of the Wnt/ß-catenin signaling cascade after traumatic nerve injury. Neuroscience. 2015 May 21; 294:101-8. PMID: 25743255.
      View in: PubMed
    9. Hoverter NP, Zeller MD, McQuade MM, Garibaldi A, Busch A, Selwan EM, Hertel KJ, Baldi P, Waterman ML. The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition. Nucleic Acids Res. 2014 Dec 16; 42(22):13615-32. PMID: 25414359.
      View in: PubMed
    10. Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML. A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open Biol. 2014 Nov; 4(11):140180. PMID: 25392452.
      View in: PubMed
    11. Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC. A three-dimensional in vitro model of tumor cell intravasation. Integr Biol (Camb). 2014 Jun; 6(6):603-10. PMID: 24763498.
      View in: PubMed
    12. MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X. Disulfide bond requirements for active Wnt ligands. J Biol Chem. 2014 Jun 27; 289(26):18122-36. PMID: 24841207.
      View in: PubMed
    13. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. PMID: 24825347.
      View in: PubMed
    14. Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI. Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J. 2014 Apr 01; 33(7):719-31. PMID: 24596249.
      View in: PubMed
    15. Konstorum A, Sprowl SA, Waterman ML, Lander AD, Lowengrub JS. Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control. J Coupled Syst Multiscale Dyn. 2013 Dec 01; 1(4):459-467. PMID: 25075381.
      View in: PubMed
    16. Cheng Y, Cheung AK, Ko JM, Phoon YP, Chiu PM, Lo PH, Waterman ML, Lung ML. Physiological ß-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma. BMC Cell Biol. 2013 Sep 27; 14:44. PMID: 24073846.
      View in: PubMed
    17. Sprowl S, Waterman ML. Past visits present: TCF/LEFs partner with ATFs for ß-catenin-independent activity. PLoS Genet. 2013; 9(8):e1003745. PMID: 23966883.
      View in: PubMed
    18. Wu B, Piloto S, Zeng W, Hoverter NP, Schilling TF, Waterman ML. Ring Finger Protein 14 is a new regulator of TCF/ß-catenin-mediated transcription and colon cancer cell survival. EMBO Rep. 2013 Apr; 14(4):347-55. PMID: 23449499.
      View in: PubMed
    19. Tsai BP, Hoverter NP, Waterman ML. Blending hippo and WNT: sharing messengers and regulation. Cell. 2012 Dec 21; 151(7):1401-3. PMID: 23260132.
      View in: PubMed
    20. Cadigan KM, Waterman ML. TCF/LEFs and Wnt signaling in the nucleus. Cold Spring Harb Perspect Biol. 2012 Nov 01; 4(11). PMID: 23024173.
      View in: PubMed
    21. Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Sci Rep. 2012; 2:568. PMID: 22891156.
      View in: PubMed
    22. Hoverter NP, Ting JH, Sundaresh S, Baldi P, Waterman ML. A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. Mol Cell Biol. 2012 Sep; 32(18):3648-62. PMID: 22778133.
      View in: PubMed
    23. Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML. A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation. 2012 Sep; 84(2):203-13. PMID: 22784633.
      View in: PubMed
    24. Najdi R, Holcombe RF, Waterman ML. Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog. 2011 Mar 17; 10:5. PMID: 21483657.
      View in: PubMed
    25. Tsai BP, Wang X, Huang L, Waterman ML. Quantitative profiling of in vivo-assembled RNA-protein complexes using a novel integrated proteomic approach. Mol Cell Proteomics. 2011 Apr; 10(4):M110.007385. PMID: 21285413.
      View in: PubMed
    26. Yokoyama NN, Pate KT, Sprowl S, Waterman ML. A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer. Nucleic Acids Res. 2010 Oct; 38(19):6375-88. PMID: 20525792.
      View in: PubMed
    27. Wang Y, Dhopeshwarkar R, Najdi R, Waterman ML, Sims CE, Allbritton N. Microdevice to capture colon crypts for in vitro studies. Lab Chip. 2010 Jun 21; 10(12):1596-603. PMID: 20376386.
      View in: PubMed
    28. Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res. 2010 Feb 15; 70(4):1469-78. PMID: 20145124.
      View in: PubMed
    29. Crampton SP, Wu B, Park EJ, Kim JH, Solomon C, Waterman ML, Hughes CC. Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS One. 2009 Nov 16; 4(11):e7841. PMID: 19924227.
      View in: PubMed
    30. Najdi R, Syed A, Arce L, Theisen H, Ting JH, Atcha F, Nguyen AV, Martinez M, Holcombe RF, Edwards RA, Marsh JL, Waterman ML. A Wnt kinase network alters nuclear localization of TCF-1 in colon cancer. Oncogene. 2009 Nov 26; 28(47):4133-46. PMID: 19749792.
      View in: PubMed
    31. Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol. 2009 Sep; 10(9):992-9. PMID: 19648923.
      View in: PubMed
    32. Ciznadija D, Tothill R, Waterman ML, Zhao L, Huynh D, Yu RM, Ernst M, Ishii S, Mantamadiotis T, Gonda TJ, Ramsay RG, Malaterre J. Intestinal adenoma formation and MYC activation are regulated by cooperation between MYB and Wnt signaling. Cell Death Differ. 2009 Nov; 16(11):1530-8. PMID: 19609274.
      View in: PubMed
    33. Arce L, Pate KT, Waterman ML. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. BMC Cancer. 2009 May 21; 9:159. PMID: 19460168.
      View in: PubMed
    34. Hoverter NP, Waterman ML. A Wnt-fall for gene regulation: repression. Sci Signal. 2008 Sep 30; 1(39):pe43. PMID: 18827220.
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    35. Semler BL, Waterman ML. IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes. Trends Microbiol. 2008 Jan; 16(1):1-5. PMID: 18083033.
      View in: PubMed
    36. Yang M, Waterman ML, Brachmann RK. hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin. Cancer Biol Ther. 2008 Jan; 7(1):120-8. PMID: 18059173.
      View in: PubMed
    37. Atcha FA, Syed A, Wu B, Hoverter NP, Yokoyama NN, Ting JH, Munguia JE, Mangalam HJ, Marsh JL, Waterman ML. A unique DNA binding domain converts T-cell factors into strong Wnt effectors. Mol Cell Biol. 2007 Dec; 27(23):8352-63. PMID: 17893322.
      View in: PubMed
    38. Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May; 45(5):318-25. PMID: 17458864.
      View in: PubMed
    39. Theisen H, Syed A, Nguyen BT, Lukacsovich T, Purcell J, Srivastava GP, Iron D, Gaudenz K, Nie Q, Wan FY, Waterman ML, Marsh JL. Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. PLoS One. 2007 Jan 03; 2(1):e142. PMID: 17206277.
      View in: PubMed
    40. Arce L, Yokoyama NN, Waterman ML. Diversity of LEF/TCF action in development and disease. Oncogene. 2006 Dec 04; 25(57):7492-504. PMID: 17143293.
      View in: PubMed
    41. Li TW, Ting JH, Yokoyama NN, Bernstein A, van de Wetering M, Waterman ML. Wnt activation and alternative promoter repression of LEF1 in colon cancer. Mol Cell Biol. 2006 Jul; 26(14):5284-99. PMID: 16809766.
      View in: PubMed
    42. Jimenez J, Jang GM, Semler BL, Waterman ML. An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. RNA. 2005 Sep; 11(9):1385-99. PMID: 16120831.
      View in: PubMed
    43. Waterman ML. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev. 2004 Jan-Jun; 23(1-2):41-52. PMID: 15000148.
      View in: PubMed
    44. Atcha FA, Munguia JE, Li TW, Hovanes K, Waterman ML. A new beta-catenin-dependent activation domain in T cell factor. J Biol Chem. 2003 May 02; 278(18):16169-75. PMID: 12582159.
      View in: PubMed
    45. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003 Jan; 23(1):131-9. PMID: 12482967.
      View in: PubMed
    46. Holcombe RF, Marsh JL, Waterman ML, Lin F, Milovanovic T, Truong T. Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. Mol Pathol. 2002 Aug; 55(4):220-6. PMID: 12147710.
      View in: PubMed
    47. Li B, Mackay DR, Dai Q, Li TW, Nair M, Fallahi M, Schonbaum CP, Fantes J, Mahowald AP, Waterman ML, Fuchs E, Dai X. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6064-9. PMID: 11983900.
      View in: PubMed
    48. Waterman ML. Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer. Curr Opin Gastroenterol. 2002 Jan; 18(1):53-9. PMID: 17031231.
      View in: PubMed
    49. Hovanes K, Li TW, Munguia JE, Truong T, Milovanovic T, Lawrence Marsh J, Holcombe RF, Waterman ML. Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. Nat Genet. 2001 May; 28(1):53-7. PMID: 11326276.
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    50. Hovanes K, Li TW, Waterman ML. The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. Nucleic Acids Res. 2000 May 01; 28(9):1994-2003. PMID: 10756202.
      View in: PubMed
    51. Prieve MG, Waterman ML. Nuclear localization and formation of beta-catenin-lymphoid enhancer factor 1 complexes are not sufficient for activation of gene expression. Mol Cell Biol. 1999 Jun; 19(6):4503-15. PMID: 10330189.
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    52. Prieve MG, Guttridge KL, Munguia J, Waterman ML. Differential importin-alpha recognition and nuclear transport by nuclear localization signals within the high-mobility-group DNA binding domains of lymphoid enhancer factor 1 and T-cell factor 1. Mol Cell Biol. 1998 Aug; 18(8):4819-32. PMID: 9671491.
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    53. Prieve MG, Guttridge KL, Munguia JE, Waterman ML. The nuclear localization signal of lymphoid enhancer factor-1 is recognized by two differentially expressed Srp1-nuclear localization sequence receptor proteins. J Biol Chem. 1996 Mar 29; 271(13):7654-8. PMID: 8631802.
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    54. Carlsson P, Waterman ML, Jones KA. The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells. Genes Dev. 1993 Dec; 7(12A):2418-30. PMID: 8253387.
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    55. Waterman ML, Fischer WH, Jones KA. A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. Genes Dev. 1991 Apr; 5(4):656-69. PMID: 2010090.
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    56. Waterman ML, Jones KA. Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner. New Biol. 1990 Jul; 2(7):621-36. PMID: 2083253.
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    57. Adler S, Waterman ML, He X, Rosenfeld MG. Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell. 1988 Mar 11; 52(5):685-95. PMID: 3345568.
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    58. Waterman ML, Adler S, Nelson C, Greene GL, Evans RM, Rosenfeld MG. A single domain of the estrogen receptor confers deoxyribonucleic acid binding and transcriptional activation of the rat prolactin gene. Mol Endocrinol. 1988 Jan; 2(1):14-21. PMID: 3398840.
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