Waterman, Marian L

Title(s)Professor, Microbiology and Molecular Genetics
Phone(949) 824-2885, 3096
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    Collapse Research 
    Collapse Research Activities and Funding
    Therapeutic targeting of Wnt & Metabolism in Colon Cancer
    NIH/NCI R03CA223929Apr 3, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Complexity, Cooperation and Community in Cancer
    NIH/NCI U54CA217378Apr 1, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    A Short Course in Cancer Systems Biology
    NIH/NCI R25CA214654Sep 18, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Coordinated regulation of alternative pre-mRNA processing in colon cancer
    NIH/NCI R01CA177651May 1, 2014 - Apr 30, 2019
    Role: Co-Principal Investigator
    TCF3: A Wnt Pathway Effector in Pluripotent Stem Cell Self-Renewal
    NIH/NIGMS R01GM096017Sep 10, 2013 - Aug 31, 2018
    Role: Co-Principal Investigator
    A 3-D In Vitro Platform of Tumor Metastasis (PQ24)
    NIH/NCI R01CA170879Aug 20, 2012 - Jun 30, 2016
    Role: Co-Principal Investigator
    LEF-1 translation in chronic myelegenous leukemia
    NIH/NCI R21CA133275Aug 10, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Wnt Signaling in Colon Cancer
    NIH/NCI R01CA108697Jul 1, 2004 - Mar 31, 2016
    Role: Principal Investigator
    LEF/TCF Expression in colon cancer
    NIH/NCI R01CA096878Jul 1, 2002 - Apr 30, 2014
    Role: Principal Investigator
    NIH/NCI R01CA083982Jan 7, 2000 - Dec 31, 2005
    Role: Principal Investigator
    NIH/NCI R01CA062079Jul 1, 1994 - Apr 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, Greenhough A, Davies S, Williams AC, Blair A, Waterman ML, Tonks A, Darley RL. LEF-1 drives aberrant ß-catenin nuclear localization in myeloid leukemia cells. Haematologica. 2019 Jan 10. PMID: 30630973.
      View in: PubMed
    2. Sierra RA, Hoverter NP, Ramirez RN, Vuong LM, Mortazavi A, Merrill BJ, Waterman ML, Donovan PJ. TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency. Development. 2018 02 23; 145(4). PMID: 29361574.
      View in: PubMed
    3. Lyou Y, Habowski AN, Chen GT, Waterman ML. Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy. Br J Pharmacol. 2017 Dec; 174(24):4589-4599. PMID: 28752891.
      View in: PubMed
    4. Lee M, Chen GT, Puttock E, Wang K, Edwards RA, Waterman ML, Lowengrub J. Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol. 2017 02 09; 13(2):912. PMID: 28183841.
      View in: PubMed
    5. Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML. Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab. 2016; 4:20. PMID: 27729975.
      View in: PubMed
    6. Chen GT, Waterman ML. Cancer: leaping the E-cadherin hurdle. EMBO J. 2015 Sep 14; 34(18):2307-9. PMID: 26282791; PMCID: PMC4570516.
    7. Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM. Differential Effects of Hepatocyte Nuclear Factor 4a Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. Mol Cell Biol. 2015 Oct; 35(20):3471-90. PMID: 26240283; PMCID: PMC4573706.
    8. Hoverter NP, Zeller MD, McQuade MM, Garibaldi A, Busch A, Selwan EM, Hertel KJ, Baldi P, Waterman ML. The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition. Nucleic Acids Res. 2014 Dec 16; 42(22):13615-32. PMID: 25414359; PMCID: PMC4267635.
    9. Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML. A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open Biol. 2014 Nov; 4(11):140180. PMID: 25392452.
      View in: PubMed
    10. Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC. A three-dimensional in vitro model of tumor cell intravasation. Integr Biol (Camb). 2014 Jun; 6(6):603-10. PMID: 24763498; PMCID: PMC4046910.
    11. MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X. Disulfide bond requirements for active Wnt ligands. J Biol Chem. 2014 Jun 27; 289(26):18122-36. PMID: 24841207; PMCID: PMC4140276.
    12. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. PMID: 24825347; PMCID: PMC4194089.
    13. Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI. Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J. 2014 Apr 01; 33(7):719-31. PMID: 24596249; PMCID: PMC4000089.
    14. Konstorum A, Sprowl SA, Waterman ML, Lander AD, Lowengrub JS. Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control. J Coupled Syst Multiscale Dyn. 2013 Dec 01; 1(4):459-467. PMID: 25075381.
      View in: PubMed
    15. Cheng Y, Cheung AK, Ko JM, Phoon YP, Chiu PM, Lo PH, Waterman ML, Lung ML. Physiological ß-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma. BMC Cell Biol. 2013 Sep 27; 14:44. PMID: 24073846; PMCID: PMC3819748.
    16. Sprowl S, Waterman ML. Past visits present: TCF/LEFs partner with ATFs for ß-catenin-independent activity. PLoS Genet. 2013; 9(8):e1003745. PMID: 23966883; PMCID: PMC3744446.
    17. Wu B, Piloto S, Zeng W, Hoverter NP, Schilling TF, Waterman ML. Ring Finger Protein 14 is a new regulator of TCF/ß-catenin-mediated transcription and colon cancer cell survival. EMBO Rep. 2013 Apr; 14(4):347-55. PMID: 23449499; PMCID: PMC3615654.
    18. Tsai BP, Hoverter NP, Waterman ML. Blending hippo and WNT: sharing messengers and regulation. Cell. 2012 Dec 21; 151(7):1401-3. PMID: 23260132.
      View in: PubMed
    19. Cadigan KM, Waterman ML. TCF/LEFs and Wnt signaling in the nucleus. Cold Spring Harb Perspect Biol. 2012 Nov 01; 4(11). PMID: 23024173; PMCID: PMC3536346.
    20. Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Sci Rep. 2012; 2:568. PMID: 22891156; PMCID: PMC3416911.
    21. Hoverter NP, Ting JH, Sundaresh S, Baldi P, Waterman ML. A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. Mol Cell Biol. 2012 Sep; 32(18):3648-62. PMID: 22778133; PMCID: PMC3430198.
    22. Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML. A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation. 2012 Sep; 84(2):203-13. PMID: 22784633; PMCID: PMC4015730.
    23. Najdi R, Holcombe RF, Waterman ML. Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog. 2011 Mar 17; 10:5. PMID: 21483657; PMCID: PMC3072659.
    24. Tsai BP, Wang X, Huang L, Waterman ML. Quantitative profiling of in vivo-assembled RNA-protein complexes using a novel integrated proteomic approach. Mol Cell Proteomics. 2011 Apr; 10(4):M110.007385. PMID: 21285413; PMCID: PMC3069349.
    25. Yokoyama NN, Pate KT, Sprowl S, Waterman ML. A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer. Nucleic Acids Res. 2010 Oct; 38(19):6375-88. PMID: 20525792; PMCID: PMC2965227.
    26. Wang Y, Dhopeshwarkar R, Najdi R, Waterman ML, Sims CE, Allbritton N. Microdevice to capture colon crypts for in vitro studies. Lab Chip. 2010 Jun 21; 10(12):1596-603. PMID: 20376386; PMCID: PMC2992468.
    27. Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res. 2010 Feb 15; 70(4):1469-78. PMID: 20145124; PMCID: PMC4010106.
    28. Crampton SP, Wu B, Park EJ, Kim JH, Solomon C, Waterman ML, Hughes CC. Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS One. 2009 Nov 16; 4(11):e7841. PMID: 19924227; PMCID: PMC2773007.
    29. Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol. 2009 Sep; 10(9):992-9. PMID: 19648923.
      View in: PubMed
    30. Arce L, Pate KT, Waterman ML. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. BMC Cancer. 2009 May 21; 9:159. PMID: 19460168; PMCID: PMC2701438.
    31. Hoverter NP, Waterman ML. A Wnt-fall for gene regulation: repression. Sci Signal. 2008 Sep 30; 1(39):pe43. PMID: 18827220.
      View in: PubMed
    32. Semler BL, Waterman ML. IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes. Trends Microbiol. 2008 Jan; 16(1):1-5. PMID: 18083033.
      View in: PubMed
    33. Yang M, Waterman ML, Brachmann RK. hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin. Cancer Biol Ther. 2008 Jan; 7(1):120-8. PMID: 18059173.
      View in: PubMed
    34. Atcha FA, Syed A, Wu B, Hoverter NP, Yokoyama NN, Ting JH, Munguia JE, Mangalam HJ, Marsh JL, Waterman ML. A unique DNA binding domain converts T-cell factors into strong Wnt effectors. Mol Cell Biol. 2007 Dec; 27(23):8352-63. PMID: 17893322; PMCID: PMC2169181.
    35. Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May; 45(5):318-25. PMID: 17458864.
      View in: PubMed
    36. Theisen H, Syed A, Nguyen BT, Lukacsovich T, Purcell J, Srivastava GP, Iron D, Gaudenz K, Nie Q, Wan FY, Waterman ML, Marsh JL. Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. PLoS One. 2007 Jan 03; 2(1):e142. PMID: 17206277.
      View in: PubMed
    37. Li TW, Ting JH, Yokoyama NN, Bernstein A, van de Wetering M, Waterman ML. Wnt activation and alternative promoter repression of LEF1 in colon cancer. Mol Cell Biol. 2006 Jul; 26(14):5284-99. PMID: 16809766; PMCID: PMC1592719.
    38. Jimenez J, Jang GM, Semler BL, Waterman ML. An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. RNA. 2005 Sep; 11(9):1385-99. PMID: 16120831; PMCID: PMC1370822.
    39. Waterman ML. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev. 2004 Jan-Jun; 23(1-2):41-52. PMID: 15000148.
      View in: PubMed
    40. Atcha FA, Munguia JE, Li TW, Hovanes K, Waterman ML. A new beta-catenin-dependent activation domain in T cell factor. J Biol Chem. 2003 May 02; 278(18):16169-75. PMID: 12582159.
      View in: PubMed
    41. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003 Jan; 23(1):131-9. PMID: 12482967; PMCID: PMC140665.
    42. Li B, Mackay DR, Dai Q, Li TW, Nair M, Fallahi M, Schonbaum CP, Fantes J, Mahowald AP, Waterman ML, Fuchs E, Dai X. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6064-9. PMID: 11983900.
      View in: PubMed
    43. Waterman ML. Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer. Curr Opin Gastroenterol. 2002 Jan; 18(1):53-9. PMID: 17031231.
      View in: PubMed