Marian L Waterman

Title(s)Professor, Microbiology and Molecular Genetics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2885, 3096
Emailmarian.waterman@uci.edu
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    Collapse Research 
    Collapse Research Activities and Funding
    Therapeutic targeting of Wnt & Metabolism in Colon Cancer
    NIH R03CA223929Apr 3, 2019 - Mar 31, 2021
    Role: Principal Investigator
    Complexity, Cooperation and Community in Cancer
    NIH U54CA217378Apr 1, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    A Short Course in Cancer Systems Biology
    NIH R25CA214654Sep 18, 2017 - Jul 31, 2023
    Role: Principal Investigator
    Coordinated regulation of alternative pre-mRNA processing in colon cancer
    NIH R01CA177651May 1, 2014 - Oct 30, 2020
    Role: Co-Principal Investigator
    TCF3: A Wnt Pathway Effector in Pluripotent Stem Cell Self-Renewal
    NIH R01GM096017Sep 10, 2013 - Aug 31, 2018
    Role: Co-Principal Investigator
    A 3-D In Vitro Platform of Tumor Metastasis (PQ24)
    NIH R01CA170879Aug 20, 2012 - Jun 30, 2017
    Role: Co-Principal Investigator
    LEF-1 translation in chronic myelegenous leukemia
    NIH R21CA133275Aug 10, 2009 - Jul 31, 2012
    Role: Principal Investigator
    Wnt Signaling in Colon Cancer
    NIH R01CA108697Jul 1, 2004 - Mar 31, 2017
    Role: Principal Investigator
    LEF/TCF Expression in colon cancer
    NIH R01CA096878Jul 1, 2002 - Apr 30, 2014
    Role: Principal Investigator
    ACTIVITIES OF BETA CATENIN AND LEF/TCF COMPLEXES
    NIH R01CA083982Jan 7, 2000 - Dec 31, 2005
    Role: Principal Investigator
    CONTROL OF T CELL RECEPTOR ALPHA CHAIN GENE EXPRESSION
    NIH R01CA062079Jul 1, 1994 - Apr 30, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Lab Chip. 2021 04 07; 21(7):1333-1351. Hachey SJ, Movsesyan S, Nguyen QH, Burton-Sojo G, Tankazyan A, Wu J, Hoang T, Zhao D, Wang S, Hatch MM, Celaya E, Gomez S, Chen GT, Davis RT, Nee K, Pervolarakis N, Lawson DA, Kessenbrock K, Lee AP, Lowengrub J, Waterman ML, Hughes CCW. PMID: 33605955.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Publisher Correction: Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. Commun Biol. 2020 Sep 03; 3(1):495. Habowski AN, Flesher JL, Bates JM, Tsai CF, Martin K, Zhao R, Ganesan AK, Edwards RA, Shi T, Wiley HS, Shi Y, Hertel KJ, Waterman ML. PMID: 32884070.
      View in: PubMed   Mentions:
    3. Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. Commun Biol. 2020 08 19; 3(1):453. Habowski AN, Flesher JL, Bates JM, Tsai CF, Martin K, Zhao R, Ganesan AK, Edwards RA, Shi T, Wiley HS, Shi Y, Hertel KJ, Waterman ML. PMID: 32814826.
      View in: PubMed   Mentions:
    4. a-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer. Nat Cancer. 2020 Mar; 1(3):345-358. Tran TQ, Hanse EA, Habowski AN, Li H, Gabra MBI, Yang Y, Lowman XH, Ooi AM, Liao SY, Edwards RA, Waterman ML, Kong M. PMID: 32832918.
      View in: PubMed   Mentions:
    5. LEF-1 drives aberrant ß-catenin nuclear localization in myeloid leukemia cells. Haematologica. 2019 07; 104(7):1365-1377. Morgan RG, Ridsdale J, Payne M, Heesom KJ, Wilson MC, Davidson A, Greenhough A, Davies S, Williams AC, Blair A, Waterman ML, Tonks A, Darley RL. PMID: 30630973.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    6. TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency. Development. 2018 02 23; 145(4). Sierra RA, Hoverter NP, Ramirez RN, Vuong LM, Mortazavi A, Merrill BJ, Waterman ML, Donovan PJ. PMID: 29361574.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    7. Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy. Br J Pharmacol. 2017 Dec; 174(24):4589-4599. Lyou Y, Habowski AN, Chen GT, Waterman ML. PMID: 28752891.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    8. Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol. 2017 02 09; 13(2):912. Lee M, Chen GT, Puttock E, Wang K, Edwards RA, Waterman ML, Lowengrub J. PMID: 28183841.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    9. Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab. 2016; 4:20. Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML. PMID: 27729975.
      View in: PubMed   Mentions:
    10. Cancer: leaping the E-cadherin hurdle. EMBO J. 2015 Sep 14; 34(18):2307-9. Chen GT, Waterman ML. PMID: 26282791.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Differential Effects of Hepatocyte Nuclear Factor 4a Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells. Mol Cell Biol. 2015 Oct; 35(20):3471-90. Vuong LM, Chellappa K, Dhahbi JM, Deans JR, Fang B, Bolotin E, Titova NV, Hoverter NP, Spindler SR, Waterman ML, Sladek FM. PMID: 26240283.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    12. The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition. Nucleic Acids Res. 2014 Dec 16; 42(22):13615-32. Hoverter NP, Zeller MD, McQuade MM, Garibaldi A, Busch A, Selwan EM, Hertel KJ, Baldi P, Waterman ML. PMID: 25414359.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    13. A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open Biol. 2014 Nov; 4(11):140180. Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML. PMID: 25392452.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. A three-dimensional in vitro model of tumor cell intravasation. Integr Biol (Camb). 2014 Jun; 6(6):603-10. Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC. PMID: 24763498.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    15. Disulfide bond requirements for active Wnt ligands. J Biol Chem. 2014 Jun 27; 289(26):18122-36. MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X. PMID: 24841207.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    16. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. PMID: 24825347.
      View in: PubMed   Mentions: 151     Fields:    Translation:HumansAnimalsCells
    17. Molecular functions of the TLE tetramerization domain in Wnt target gene repression. EMBO J. 2014 Apr 01; 33(7):719-31. Chodaparambil JV, Pate KT, Hepler MR, Tsai BP, Muthurajan UM, Luger K, Waterman ML, Weis WI. PMID: 24596249.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    18. Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control. J Coupled Syst Multiscale Dyn. 2013 Dec 01; 1(4):459-467. Konstorum A, Sprowl SA, Waterman ML, Lander AD, Lowengrub JS. PMID: 25075381.
      View in: PubMed   Mentions:
    19. Physiological ß-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma. BMC Cell Biol. 2013 Sep 27; 14:44. Cheng Y, Cheung AK, Ko JM, Phoon YP, Chiu PM, Lo PH, Waterman ML, Lung ML. PMID: 24073846.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    20. Past visits present: TCF/LEFs partner with ATFs for ß-catenin-independent activity. PLoS Genet. 2013; 9(8):e1003745. Sprowl S, Waterman ML. PMID: 23966883.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    21. Ring Finger Protein 14 is a new regulator of TCF/ß-catenin-mediated transcription and colon cancer cell survival. . 2013 Apr; 14(4):347-55. Wu B, Piloto S, Zeng W, Hoverter NP, Schilling TF, Waterman ML. PMID: 23449499.
      View in: PubMed   Mentions:
    22. Blending hippo and WNT: sharing messengers and regulation. Cell. 2012 Dec 21; 151(7):1401-3. Tsai BP, Hoverter NP, Waterman ML. PMID: 23260132.
      View in: PubMed   Mentions: 15     Fields:    
    23. TCF/LEFs and Wnt signaling in the nucleus. Cold Spring Harb Perspect Biol. 2012 Nov 01; 4(11). Cadigan KM, Waterman ML. PMID: 23024173.
      View in: PubMed   Mentions: 235     Fields:    Translation:AnimalsCells
    24. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Sci Rep. 2012; 2:568. Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E. PMID: 22891156.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    25. A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. Mol Cell Biol. 2012 Sep; 32(18):3648-62. Hoverter NP, Ting JH, Sundaresh S, Baldi P, Waterman ML. PMID: 22778133.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    26. A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation. 2012 Sep; 84(2):203-13. Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML. PMID: 22784633.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    27. Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog. 2011 Mar 17; 10:5. Najdi R, Holcombe RF, Waterman ML. PMID: 21483657.
      View in: PubMed   Mentions:
    28. Quantitative profiling of in vivo-assembled RNA-protein complexes using a novel integrated proteomic approach. Mol Cell Proteomics. 2011 Apr; 10(4):M110.007385. Tsai BP, Wang X, Huang L, Waterman ML. PMID: 21285413.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    29. A role for YY1 in repression of dominant negative LEF-1 expression in colon cancer. Nucleic Acids Res. 2010 Oct; 38(19):6375-88. Yokoyama NN, Pate KT, Sprowl S, Waterman ML. PMID: 20525792.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    30. Microdevice to capture colon crypts for in vitro studies. Lab Chip. 2010 Jun 21; 10(12):1596-603. Wang Y, Dhopeshwarkar R, Najdi R, Waterman ML, Sims CE, Allbritton N. PMID: 20376386.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    31. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res. 2010 Feb 15; 70(4):1469-78. Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. PMID: 20145124.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    32. Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS One. 2009 Nov 16; 4(11):e7841. Crampton SP, Wu B, Park EJ, Kim JH, Solomon C, Waterman ML, Hughes CC. PMID: 19924227.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    33. T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol. 2009 Sep; 10(9):992-9. Yu Q, Sharma A, Oh SY, Moon HG, Hossain MZ, Salay TM, Leeds KE, Du H, Wu B, Waterman ML, Zhu Z, Sen JM. PMID: 19648923.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    34. Groucho binds two conserved regions of LEF-1 for HDAC-dependent repression. BMC Cancer. 2009 May 21; 9:159. Arce L, Pate KT, Waterman ML. PMID: 19460168.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    35. A Wnt-fall for gene regulation: repression. Sci Signal. 2008 Sep 30; 1(39):pe43. Hoverter NP, Waterman ML. PMID: 18827220.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    36. IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes. Trends Microbiol. 2008 Jan; 16(1):1-5. Semler BL, Waterman ML. PMID: 18083033.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    37. hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin. . 2008 Jan; 7(1):120-8. Yang M, Waterman ML, Brachmann RK. PMID: 18059173.
      View in: PubMed   Mentions:
    38. A unique DNA binding domain converts T-cell factors into strong Wnt effectors. Mol Cell Biol. 2007 Dec; 27(23):8352-63. Atcha FA, Syed A, Wu B, Hoverter NP, Yokoyama NN, Ting JH, Munguia JE, Mangalam HJ, Marsh JL, Waterman ML. PMID: 17893322.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    39. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May; 45(5):318-25. Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. PMID: 17458864.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    40. Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. PLoS One. 2007 Jan 03; 2(1):e142. Theisen H, Syed A, Nguyen BT, Lukacsovich T, Purcell J, Srivastava GP, Iron D, Gaudenz K, Nie Q, Wan FY, Waterman ML, Marsh JL. PMID: 17206277.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    41. Wnt activation and alternative promoter repression of LEF1 in colon cancer. Mol Cell Biol. 2006 Jul; 26(14):5284-99. Li TW, Ting JH, Yokoyama NN, Bernstein A, van de Wetering M, Waterman ML. PMID: 16809766.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    42. An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. RNA. 2005 Sep; 11(9):1385-99. Jimenez J, Jang GM, Semler BL, Waterman ML. PMID: 16120831.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    43. Lymphoid enhancer factor/T cell factor expression in colorectal cancer. Cancer Metastasis Rev. 2004 Jan-Jun; 23(1-2):41-52. Waterman ML. PMID: 15000148.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    44. A new beta-catenin-dependent activation domain in T cell factor. J Biol Chem. 2003 May 02; 278(18):16169-75. Atcha FA, Munguia JE, Li TW, Hovanes K, Waterman ML. PMID: 12582159.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    45. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003 Jan; 23(1):131-9. Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K. PMID: 12482967.
      View in: PubMed   Mentions: 195     Fields:    Translation:HumansAnimalsCells
    46. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6064-9. Li B, Mackay DR, Dai Q, Li TW, Nair M, Fallahi M, Schonbaum CP, Fantes J, Mahowald AP, Waterman ML, Fuchs E, Dai X. PMID: 11983900.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    47. Expression of lymphoid enhancer factor/T-cell factor proteins in colon cancer. Curr Opin Gastroenterol. 2002 Jan; 18(1):53-9. Waterman ML. PMID: 17031231.
      View in: PubMed   Mentions: 3     Fields:    
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