Cholsoon Jang

Title(s)Assistant Professor, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-6052
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    1. Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers. bioRxiv. 2024 Mar 26. Lee G, Wong C, Cho A, West JJ, Crawford AJ, Russo GC, Si BR, Kim J, Hoffner L, Jang C, Jung M, Leone RD, Konstantopoulos K, Ewald AJ, Wirtz D, Jeong S. PMID: 37292712; PMCID: PMC10245808.
      View in: PubMed   Mentions:
    2. A PTER-dependent pathway of taurine metabolism linked to energy balance. bioRxiv. 2024 Mar 22. Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, Cavanagh PE, Zeng X, Rajniak J, Lu N, Xiao S, Zhao M, Dolores Moya-Garzon M, Truong SD, Chou JC, Wat LW, Chidambaranathan-Reghupaty S, Coassolo L, Xu D, Shen F, Huang W, Ramirez CB, Jang C, Svensson KJ, Fischbach MA, Long JZ. PMID: 38562797; PMCID: PMC10983888.
      View in: PubMed   Mentions:
    3. Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. bioRxiv. 2024 Mar 10. Bowman CE, Neinast MD, Jang C, Patel J, Blair MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z. PMID: 38496495; PMCID: PMC10942310.
      View in: PubMed   Mentions:
    4. The landscape of fetus metabolism in maternal hyperglycemia. Trends Endocrinol Metab. 2024 Feb 09. Kelly ME, Martinez TF, Jang C. PMID: 38341338.
      View in: PubMed   Mentions:    Fields:    
    5. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. Elife. 2024 Jan 15; 12. Zhou M, Tamburini I, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo R, Bae H, Le J, Larson N, Pulido R, Nascimento-Filho CHV, Jang C, Marazzi I, Justice J, Pannunzio N, Hevener AL, Sparks L, Kershaw EE, Nicholas D, Parker BL, Masri S, Seldin MM. PMID: 38224289; PMCID: PMC10945578.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation. Mol Cell. 2023 Dec 07; 83(23):4255-4271.e9. Torre D, Fstkchyan YS, Ho JSY, Cheon Y, Patel RS, Degrace EJ, Mzoughi S, Schwarz M, Mohammed K, Seo JS, Romero-Bueno R, Demircioglu D, Hasson D, Tang W, Mahajani SU, Campisi L, Zheng S, Song WS, Wang YC, Shah H, Francoeur N, Soto J, Salfati Z, Weirauch MT, Warburton P, Beaumont K, Smith ML, Mulder L, Villalta SA, Kessenbrock K, Jang C, Lee D, De Rubeis S, Cobos I, Tam O, Hammell MG, Seldin M, Shi Y, Basu U, Sebastiano V, Byun M, Sebra R, Rosenberg BR, Benner C, Guccione E, Marazzi I. PMID: 37995687; PMCID: PMC10842741.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    7. Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice. Cell Metab. 2023 11 07; 35(11):1976-1995.e6. Green CL, Trautman ME, Chaiyakul K, Jain R, Alam YH, Babygirija R, Pak HH, Sonsalla MM, Calubag MF, Yeh CY, Bleicher A, Novak G, Liu TT, Newman S, Ricke WA, Matkowskyj KA, Ong IM, Jang C, Simcox J, Lamming DW. PMID: 37939658; PMCID: PMC10655617.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    8. Aberrant splicing in Huntington's disease via disrupted TDP-43 activity accompanied by altered m6A RNA modification. bioRxiv. 2023 Nov 02. Nguyen TB, Miramontes R, Chillon-Marinas C, Maimon R, Vazquez-Sanchez S, Lau AL, McClure NR, England WE, Singha M, Stocksdale JT, Jang KH, Jung S, McKnight JI, Ho LN, Faull RLM, Steffan JS, Reidling JC, Jang C, Lee G, Cleveland DW, Lagier-Tourenne C, Spitale RC, Thompson LM. PMID: 37961595; PMCID: PMC10635028.
      View in: PubMed   Mentions:
    9. Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells. Nature. 2023 Nov; 623(7987):625-632. Doshi MB, Lee N, Tseyang T, Ponomarova O, Goel HL, Spears M, Li R, Zhu LJ, Ashwood C, Simin K, Jang C, Mercurio AM, Walhout AJM, Spinelli JB, Kim D. PMID: 37880368; PMCID: PMC10709823.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. bioRxiv. 2023 Oct 04. Zhou M, Tamburini IJ, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo RX, Bae H, Le J, Larson N, Pulido R, Filho C, Jang C, Marazzi I, Justice JN, Pannunzio N, Hevener A, Sparks LM, Kershaw EE, Nicholas D, Parker B, Masri S, Seldin M. PMID: 37214953; PMCID: PMC10197628.
      View in: PubMed   Mentions:
    11. A new era of understanding in vivo metabolic flux in thermogenic adipocytes. Curr Opin Genet Dev. 2023 Dec; 83:102112. Haley JA, Jang C, Guertin DA. PMID: 37703635; PMCID: PMC10840980.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. MAPK13 stabilization via m6A mRNA modification limits anticancer efficacy of rapamycin. J Biol Chem. 2023 Sep; 299(9):105175. Kim J, Chun Y, Ramirez CB, Hoffner LA, Jung S, Jang KH, Rubtsova VI, Jang C, Lee G. PMID: 37599001; PMCID: PMC10511813.
      View in: PubMed   Mentions:    Fields:    
    13. FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1. Mol Cell. 2023 08 17; 83(16):3010-3026.e8. Cho S, Chun Y, He L, Ramirez CB, Ganesh KS, Jeong K, Song J, Cheong JG, Li Z, Choi J, Kim J, Koundouros N, Ding F, Dephoure N, Jang C, Blenis J, Lee G. PMID: 37595559; PMCID: PMC10494788.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis. Nat Metab. 2023 07; 5(7):1204-1220. Park G, Haley JA, Le J, Jung SM, Fitzgibbons TP, Korobkina ED, Li H, Fluharty SM, Chen Q, Spinelli JB, Trivedi CM, Jang C, Guertin DA. PMID: 37337122; PMCID: PMC10696589.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    15. Acetate controls endothelial-to-mesenchymal transition. Cell Metab. 2023 07 11; 35(7):1163-1178.e10. Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. PMID: 37327791; PMCID: PMC10529701.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    16. Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood. Cell Metab. 2023 07 11; 35(7):1227-1241.e7. Lin L, Jung KM, Lee HL, Le J, Colleluori G, Wood C, Palese F, Squire E, Ramirez J, Su S, Torrens A, Fotio Y, Tang L, Yu C, Yang Q, Huang L, DiPatrizio N, Jang C, Cinti S, Piomelli D. PMID: 37267956; PMCID: PMC10524841.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    17. Liver and muscle circadian clocks cooperate to support glucose tolerance in mice. Cell Rep. 2023 06 27; 42(6):112588. Smith JG, Koronowski KB, Mortimer T, Sato T, Greco CM, Petrus P, Verlande A, Chen S, Samad M, Deyneka E, Mathur L, Blazev R, Molendijk J, Kumar A, Deryagin O, Vaca-Dempere M, Sica V, Liu P, Orlando V, Parker BL, Baldi P, Welz PS, Jang C, Masri S, Benitah SA, Muñoz-Cánoves P, Sassone-Corsi P. PMID: 37267101; PMCID: PMC10592114.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    18. Ovol1/2 loss-induced epidermal defects elicit skin immune activation and alter global metabolism. EMBO Rep. 2023 Jul 05; 24(7):e56214. Dragan M, Chen Z, Li Y, Le J, Sun P, Haensel D, Sureshchandra S, Pham A, Lu E, Pham KT, Verlande A, Vu R, Gutierrez G, Li W, Jang C, Masri S, Dai X. PMID: 37249012; PMCID: PMC10328084.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    19. Maternal low-calorie sweetener consumption rewires hypothalamic melanocortin circuits via a gut microbial co-metabolite pathway. JCI Insight. 2023 05 22; 8(10). Park S, Belfoul AM, Rastelli M, Jang A, Monnoye M, Bae H, Kamitakahara A, Giavalisco P, Sun S, Barelle PY, Plows J, Jang C, Fodor A, Goran MI, Bouret SG. PMID: 37014702; PMCID: PMC10322686.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    20. Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nat Metab. 2023 04; 5(4):589-606. Blair MC, Neinast MD, Jang C, Chu Q, Jung JW, Axsom J, Bornstein MR, Thorsheim C, Li K, Hoshino A, Yang S, Roth Flach RJ, Zhang BB, Rabinowitz JD, Arany Z. PMID: 37100997; PMCID: PMC10278155.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    21. Hepatocyte SREBP signaling mediates clock communication within the liver. J Clin Invest. 2023 04 17; 133(8). Guan D, Bae H, Zhou D, Chen Y, Jiang C, La CM, Xiao Y, Zhu K, Hu W, Trinh TM, Liu P, Xiong Y, Cai B, Jang C, Lazar MA. PMID: 37066875; PMCID: PMC10104893.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    22. Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell Metab. 2022 11 01; 34(11):1749-1764.e7. Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z. PMID: 36223763; PMCID: PMC9633425.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    23. AIFM2 Is Required for High-Intensity Aerobic Exercise in Promoting Glucose Utilization. Diabetes. 2022 10 01; 71(10):2084-2093. Nguyen HP, Villivalam SD, Jung BC, You D, Lin F, Yi D, Pi A, Ma K, Jung S, Park SH, Jang C, Sul HS, Kang S. PMID: 35772021; PMCID: PMC9501658.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    24. Metabolic flux between organs measured by arteriovenous metabolite gradients. Exp Mol Med. 2022 Sep; 54(9):1354-1366. Bae H, Lam K, Jang C. PMID: 36075951; PMCID: PMC9534916.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    25. Sex-dependent effects of multiple acute concurrent stresses on memory: a role for hippocampal estrogens. Front Behav Neurosci. 2022; 16:984494. Hokenson RE, Alam YH, Short AK, Jung S, Jang C, Baram TZ. PMID: 36160685; PMCID: PMC9492881.
      View in: PubMed   Mentions: 1  
    26. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab. 2022 Sep 06; 34(9):1410. Jang C, Hui S, Zeng X, Cowan AJ, Wang L, Chen L, Morscher RJ, Reyes J, Frezza C, Hwang HY, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido GA, Gorman JH, Gorman RC, Rabinowitz JD. PMID: 36070684; PMCID: PMC9514224.
      View in: PubMed   Mentions: 1     Fields:    
    27. Gut bacterial nutrient preferences quantified in vivo. Cell. 2022 09 01; 185(18):3441-3456.e19. Zeng X, Xing X, Gupta M, Keber FC, Lopez JG, Lee YJ, Roichman A, Wang L, Neinast MD, Donia MS, Wühr M, Jang C, Rabinowitz JD. PMID: 36055202; PMCID: PMC9450212.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    28. Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy. Nat Cardiovasc Res. 2022 Sep; 1(9):817-829. Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, Arany Z. PMID: 36776621; PMCID: PMC9910091.
      View in: PubMed   Mentions: 12  
    29. Dietary Fructose and Fructose-Induced Pathologies. Annu Rev Nutr. 2022 08 22; 42:45-66. Jung S, Bae H, Song WS, Jang C. PMID: 35995049; PMCID: PMC9904196.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    30. Discovery of compounds that reactivate p53 mutants in vitro and in vivo. Cell Chem Biol. 2022 09 15; 29(9):1381-1395.e13. Durairaj G, Demir Ö, Lim B, Baronio R, Tifrea D, Hall LV, DeForest JC, Lauinger L, Jebril Fallatah MM, Yu C, Bae H, Lin DW, Kim JK, Salehi F, Jang C, Qiao F, Lathrop RH, Huang L, Edwards R, Rychnovsky S, Amaro RE, Kaiser P. PMID: 35948006; PMCID: PMC9481737.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. Tryptophan metabolism is a physiological integrator regulating circadian rhythms. Mol Metab. 2022 10; 64:101556. Petrus P, Cervantes M, Samad M, Sato T, Chao A, Sato S, Koronowski KB, Park G, Alam Y, Mejhert N, Seldin MM, Monroy Kuhn JM, Dyar KA, Lutter D, Baldi P, Kaiser P, Jang C, Sassone-Corsi P. PMID: 35914650; PMCID: PMC9382333.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    32. Glycerate from intestinal fructose metabolism induces islet cell damage and glucose intolerance. Cell Metab. 2022 07 05; 34(7):1042-1053.e6. Wu Y, Wong CW, Chiles EN, Mellinger AL, Bae H, Jung S, Peterson T, Wang J, Negrete M, Huang Q, Wang L, Jang C, Muddiman DC, Su X, Williamson I, Shen X. PMID: 35688154; PMCID: PMC9897509.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species. J Lipid Res. 2022 06; 63(6):100224. Doan MT, Neinast MD, Varner EL, Bedi KC, Bartee D, Jiang H, Trefely S, Xu P, Singh JP, Jang C, Rame JE, Brady DC, Meier JL, Marguiles KB, Arany Z, Snyder NW. PMID: 35568254; PMCID: PMC9189226.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    34. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. Science. 2022 04 15; 376(6590):eabf8271. Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z. PMID: 35420934; PMCID: PMC9811404.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    35. Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance. EMBO J. 2022 05 02; 41(9):e109890. Lee HW, Xu Y, Zhu X, Jang C, Choi W, Bae H, Wang W, He L, Jin SW, Arany Z, Simons M. PMID: 35243676; PMCID: PMC9058541.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    36. Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction. Cell Metab. 2022 02 01; 34(2):209-226.e5. Green CL, Pak HH, Richardson NE, Flores V, Yu D, Tomasiewicz JL, Dumas SN, Kredell K, Fan JW, Kirsh C, Chaiyakul K, Murphy ME, Babygirija R, Barrett-Wilt GA, Rabinowitz J, Ong IM, Jang C, Simcox J, Lamming DW. PMID: 35108511; PMCID: PMC8865085.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    37. Circulating metabolite homeostasis achieved through mass action. Nat Metab. 2022 01; 4(1):141-152. Li X, Hui S, Mirek ET, Jonsson WO, Anthony TG, Lee WD, Zeng X, Jang C, Rabinowitz JD. PMID: 35058631; PMCID: PMC9244777.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Metabolism and Health Impacts of Dietary Sugars. J Lipid Atheroscler. 2022 Jan; 11(1):20-38. Alam YH, Kim R, Jang C. PMID: 35118020; PMCID: PMC8792817.
      View in: PubMed   Mentions: 7  
    39. Genetic Variation in Sugar Metabolism Confers a Protective Metabolic Profile. Gastroenterology. 2022 04; 162(4):1033-1035. Le J, Jang C. PMID: 35007516.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    40. Stable Isotope Tracing and Metabolomics to Study In Vivo Brown Adipose Tissue Metabolic Fluxes. Methods Mol Biol. 2022; 2448:119-130. Jung SM, Le J, Doxsey WG, Haley JA, Park G, Guertin DA, Jang C. PMID: 35167094; PMCID: PMC9924221.
      View in: PubMed   Mentions: 1     Fields:    
    41. Bi-allelic variants in OGDHL cause a neurodevelopmental spectrum disease featuring epilepsy, hearing loss, visual impairment, and ataxia. Am J Hum Genet. 2021 12 02; 108(12):2368-2384. Yap ZY, Efthymiou S, Seiffert S, Vargas Parra K, Lee S, Nasca A, Maroofian R, Schrauwen I, Pendziwiat M, Jung S, Bhoj E, Striano P, Mankad K, Vona B, Cuddapah S, Wagner A, Alvi JR, Davoudi-Dehaghani E, Fallah MS, Gannavarapu S, Lamperti C, Legati A, Murtaza BN, Nadeem MS, Rehman MU, Saeidi K, Salpietro V, von Spiczak S, Sandoval A, Zeinali S, Zeviani M, Reich A, SYNaPS Study Group, University of Washington Center for Mendelian Genomics, Jang C, Helbig I, Barakat TS, Ghezzi D, Leal SM, Weber Y, Houlden H, Yoon WH. PMID: 34800363; PMCID: PMC8715183.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. NAAA-regulated lipid signaling governs the transition from acute to chronic pain. Sci Adv. 2021 Oct 22; 7(43):eabi8834. Fotio Y, Jung KM, Palese F, Obenaus A, Tagne AM, Lin L, Rashid TI, Pacheco R, Jullienne A, Ramirez J, Mor M, Spadoni G, Jang C, Hohmann AG, Piomelli D. PMID: 34678057; PMCID: PMC8535814.
      View in: PubMed   Mentions: 8     Fields:    
    43. Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity. Circ Res. 2021 11 12; 129(11):1054-1066. Basehore SE, Bohlman S, Weber C, Swaminathan S, Zhang Y, Jang C, Arany Z, Clyne AM. PMID: 34605247; PMCID: PMC8653916.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. Quantitative analysis of m6A RNA modification by LC-MS. STAR Protoc. 2021 09 17; 2(3):100724. Mathur L, Jung S, Jang C, Lee G. PMID: 34401789; PMCID: PMC8353476.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    45. Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation. Cell Rep. 2021 08 03; 36(5):109487. Koronowski KB, Greco CM, Huang H, Kim JK, Fribourgh JL, Crosby P, Mathur L, Ren X, Partch CL, Jang C, Qiao F, Zhao Y, Sassone-Corsi P. PMID: 34348140; PMCID: PMC8372761.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    46. In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate. Cell Rep. 2021 07 27; 36(4):109459. Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK, Li H, Jang C, Guertin DA. PMID: 34320357; PMCID: PMC8369932.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    47. Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids. Hepatology. 2021 12; 74(6):3427-3440. Saiman Y, Shen TD, Lund PJ, Gershuni VM, Jang C, Patel S, Jung S, Furth EE, Friedman ES, Chau L, Garcia BA, Wu GD. PMID: 34233020; PMCID: PMC9867598.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    48. Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a model of lung cancer-associated cachexia. Sci Adv. 2021 06; 7(26). Verlande A, Chun SK, Goodson MO, Fortin BM, Bae H, Jang C, Masri S. PMID: 34172439; PMCID: PMC8232919.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    49. Disparate Metabolomic Responses to Fructose Consumption between Different Mouse Strains and the Role of Gut Microbiota. Metabolites. 2021 May 26; 11(6). Ahn IS, Yoon J, Diamante G, Cohn P, Jang C, Yang X. PMID: 34073358; PMCID: PMC8228112.
      View in: PubMed   Mentions: 3  
    50. The interaction between the gut microbiota and dietary carbohydrates in nonalcoholic fatty liver disease. Exp Mol Med. 2021 05; 53(5):809-822. Park G, Jung S, Wellen KE, Jang C. PMID: 34017059; PMCID: PMC8178320.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    51. The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine. Cell Metab. 2021 05 04; 33(5):905-922.e6. Yu D, Richardson NE, Green CL, Spicer AB, Murphy ME, Flores V, Jang C, Kasza I, Nikodemova M, Wakai MH, Tomasiewicz JL, Yang SE, Miller BR, Pak HH, Brinkman JA, Rojas JM, Quinn WJ, Cheng EP, Konon EN, Haider LR, Finke M, Sonsalla M, Alexander CM, Rabinowitz JD, Baur JA, Malecki KC, Lamming DW. PMID: 33887198; PMCID: PMC8102360.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimals
    52. mTORC1 promotes cell growth via m6A-dependent mRNA degradation. Mol Cell. 2021 05 20; 81(10):2064-2075.e8. Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J. PMID: 33756105; PMCID: PMC8356906.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    53. Organismal Fructose Metabolism in Health and Non-Alcoholic Fatty Liver Disease. Biology (Basel). 2020 Nov 18; 9(11). Skenderian S, Park G, Jang C. PMID: 33218081; PMCID: PMC7698815.
      View in: PubMed   Mentions: 5  
    54. Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science. 2020 10 16; 370(6514):364-368. Murashige D, Jang C, Neinast M, Edwards JJ, Cowan A, Hyman MC, Rabinowitz JD, Frankel DS, Arany Z. PMID: 33060364; PMCID: PMC7871704.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    55. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020 10 06; 32(4):676-688.e4. Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. PMID: 32791100; PMCID: PMC7544659.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    56. The hepatocyte clock and feeding control chronophysiology of multiple liver cell types. Science. 2020 09 11; 369(6509):1388-1394. Guan D, Xiong Y, Trinh TM, Xiao Y, Hu W, Jiang C, Dierickx P, Jang C, Rabinowitz JD, Lazar MA. PMID: 32732282; PMCID: PMC7849028.
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    57. The small intestine shields the liver from fructose-induced steatosis. Nat Metab. 2020 07; 2(7):586-593. Jang C, Wada S, Yang S, Gosis B, Zeng X, Zhang Z, Shen Y, Lee G, Arany Z, Rabinowitz JD. PMID: 32694791; PMCID: PMC8020332.
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    58. Angiopoietin-2-integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance. Nat Commun. 2020 06 12; 11(1):2980. Bae H, Hong KY, Lee CK, Jang C, Lee SJ, Choe K, Offermanns S, He Y, Lee HJ, Koh GY. PMID: 32532986; PMCID: PMC7293240.
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    59. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 2020 03; 579(7800):586-591. Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller KD, Schug ZT, Snyder NW, Gade TP, Titchenell PM, Rabinowitz JD, Wellen KE. PMID: 32214246; PMCID: PMC7416516.
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    60. Serine Catabolism Feeds NADH when Respiration Is Impaired. Cell Metab. 2020 04 07; 31(4):809-821.e6. Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, Mayr JA, Zhang Z, Ghergurovich JM, Zhan L, Joshi S, Hu Z, McReynolds MR, Su X, White E, Morscher RJ, Rabinowitz JD. PMID: 32187526; PMCID: PMC7397714.
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    61. Effect of Interleukin-15 Receptor Alpha Ablation on the Metabolic Responses to Moderate Exercise Simulated by in vivo Isometric Muscle Contractions. Front Physiol. 2019; 10:1439. Loro E, Jang C, Quinn WJ, Baur JA, Arany ZP, Khurana TS. PMID: 31849697; PMCID: PMC6901992.
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    62. Metabolite Exchange between Mammalian Organs Quantified in Pigs. Cell Metab. 2019 09 03; 30(3):594-606.e3. Jang C, Hui S, Zeng X, Cowan AJ, Wang L, Chen L, Morscher RJ, Reyes J, Frezza C, Hwang HY, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido GA, Gorman JH, Gorman RC, Rabinowitz JD. PMID: 31257152; PMCID: PMC6726553.
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    63. Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation. Science. 2019 02 08; 363(6427):644-649. Lee CK, Jeong SH, Jang C, Bae H, Kim YH, Park I, Kim SK, Koh GY. PMID: 30733421.
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    64. Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids. Cell Metab. 2019 02 05; 29(2):417-429.e4. Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z. PMID: 30449684; PMCID: PMC6365191.
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    65. Endothelial pyruvate kinase M2 maintains vascular integrity. J Clin Invest. 2018 10 01; 128(10):4543-4556. Kim B, Jang C, Dharaneeswaran H, Li J, Bhide M, Yang S, Li K, Arany Z. PMID: 30222136; PMCID: PMC6159968.
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    66. Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. 2018 08 09; 174(4):831-842.e12. Guan D, Xiong Y, Borck PC, Jang C, Doulias PT, Papazyan R, Fang B, Jiang C, Zhang Y, Briggs ER, Hu W, Steger D, Ischiropoulos H, Rabinowitz JD, Lazar MA. PMID: 30057115; PMCID: PMC6086765.
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    67. Fructose metabolism, cardiometabolic risk, and the epidemic of coronary artery disease. Eur Heart J. 2018 07 07; 39(26):2497-2505. Mirtschink P, Jang C, Arany Z, Krek W. PMID: 29020416; PMCID: PMC6037111.
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    68. Metabolomics and Isotope Tracing. Cell. 2018 05 03; 173(4):822-837. Jang C, Chen L, Rabinowitz JD. PMID: 29727671; PMCID: PMC6034115.
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    69. Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice. J Clin Invest. 2018 06 01; 128(6):2226-2238. Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR. PMID: 29533924; PMCID: PMC5983342.
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    70. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab. 2018 02 06; 27(2):351-361.e3. Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD. PMID: 29414685; PMCID: PMC6032988.
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    71. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. 2017 Dec 14; 171(7):1545-1558.e18. Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J. PMID: 29153836; PMCID: PMC5920692.
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    72. Glucose feeds the TCA cycle via circulating lactate. Nature. 2017 11 02; 551(7678):115-118. Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Yanxiang Guo J, White E, Rabinowitz JD. PMID: 29045397; PMCID: PMC5898814.
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    73. PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy. Circ Res. 2017 Dec 08; 121(12):1370-1378. Liu LX, Rowe GC, Yang S, Li J, Damilano F, Chan MC, Lu W, Jang C, Wada S, Morley M, Hesse M, Fleischmann BK, Rabinowitz JD, Das S, Rosenzweig A, Arany Z. PMID: 28928113; PMCID: PMC5722682.
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    74. Glutamine fuels proliferation but not migration of endothelial cells. EMBO J. 2017 08 15; 36(16):2321-2333. Kim B, Li J, Jang C, Arany Z. PMID: 28659379; PMCID: PMC5556269.
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    75. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 2016 11 15; 30(22):2551-2564. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. PMID: 27913603; PMCID: PMC5159669.
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    76. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016 Apr; 22(4):421-6. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. PMID: 26950361; PMCID: PMC4949205.
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    77. Mitochondria Cripple without Krüppel. Trends Endocrinol Metab. 2015 Nov; 26(11):587-589. Jang C, Arany Z. PMID: 26404663; PMCID: PMC4797320.
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    78. PGC-1α induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014 Aug 15; 115(5):504-17. Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird WC, Arany Z. PMID: 25009290; PMCID: PMC4524357.
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    79. Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor γ coactivator (PGC)-1α. J Biol Chem. 2014 Mar 28; 289(13):8810-7. Thom R, Rowe GC, Jang C, Safdar A, Arany Z. PMID: 24505137; PMCID: PMC3979394.
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    80. WITHDRAWN: Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by N-Terminus Peroxisome Proliferator-Activated Receptor Gamma Coactivator (NT-PGC)-1alpha. J Biol Chem. 2014 Jan 15. Thom R, Rowe GC, Jang C, Safdar A, White JP, Arany Z. PMID: 24398674.
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    81. Metabolism: Sweet enticements to move. Nature. 2013 Aug 22; 500(7463):409-11. Jang C, Arany Z. PMID: 23945589; PMCID: PMC4554390.
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    82. Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature. 2012 May 09; 485(7398):333-8. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker MR, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. PMID: 22596155; PMCID: PMC3356917.
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    83. UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila. Dev Biol. 2011 Aug 15; 356(2):588-97. Lee G, Liang C, Park G, Jang C, Jung JU, Chung J. PMID: 21729695; PMCID: PMC4414087.
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    84. PGC-1β regulates angiogenesis in skeletal muscle. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E155-63. Rowe GC, Jang C, Patten IS, Arany Z. PMID: 21364124; PMCID: PMC3275155.
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    85. Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice. Diabetes. 2009 Apr; 58(4):965-74. Hwang JH, Kim DW, Jo EJ, Kim YK, Jo YS, Park JH, Yoo SK, Park MK, Kwak TH, Kho YL, Han J, Choi HS, Lee SH, Kim JM, Lee I, Kyung T, Jang C, Chung J, Kweon GR, Shong M. PMID: 19136651; PMCID: PMC2661596.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    86. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. J Cell Biol. 2008 Oct 06; 183(1):11-7. Jang C, Lee G, Chung J. PMID: 18838551; PMCID: PMC2557035.
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    87. Membrane proteomic analysis of human mesenchymal stromal cells during adipogenesis. Proteomics. 2007 Nov; 7(22):4181-91. Jeong JA, Ko KM, Park HS, Lee J, Jang C, Jeon CJ, Koh GY, Kim H. PMID: 17994623.
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