Wei Ling Lau

Title(s)Associate Professor In Residence, DOM Nephrology & Hypertension
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. Brain & Kidney 2020: Introduction to Special Issue. J Stroke Cerebrovasc Dis. 2021 Jul 19; 105990. Fisher M, Lau WL, Coull B. PMID: 34294539.
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    2. Spectroscopic and deep learning-based approaches to identify and quantify cerebral microhemorrhages. Sci Rep. 2021 May 21; 11(1):10725. Crouzet C, Jeong G, Chae RH, LoPresti KT, Dunn CE, Xie DF, Agu C, Fang C, Nunes ACF, Lau WL, Kim S, Cribbs DH, Fisher M, Choi B. PMID: 34021170.
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    3. Cardiovascular and Bleeding Outcomes with Anticoagulants across Kidney Disease Stages: Analysis of a National US Cohort. Am J Nephrol. 2021 Mar 31; 1-10. Sy J, Hsiung JT, Edgett D, Kalantar-Zadeh K, Streja E, Lau WL. PMID: 33789276.
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    4. Cerebral Blood Flow in Chronic Kidney Disease. J Stroke Cerebrovasc Dis. 2021 Mar 10; 105702. Choi B, Crouzet C, Lau WL, Cribbs DH, Fisher MJ. PMID: 33714675.
      View in: PubMed   Mentions:    Fields:    
    5. Diabetes and the Gut Microbiome. Semin Nephrol. 2021 Mar; 41(2):104-113. Lau WL, Tran T, Rhee CM, Kalantar-Zadeh K, Vaziri ND. PMID: 34140089.
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    6. Controversies: Stroke Prevention in Chronic Kidney Disease. J Stroke Cerebrovasc Dis. 2021 Feb 25; 105679. Lau WL. PMID: 33640261.
      View in: PubMed   Mentions:    Fields:    
    7. The COVID-Kidney Controversy: Can SARS-CoV-2 Cause Direct Renal Infection? Nephron. 2021; 145(3):275-279. Lau WL, Zuckerman JE, Gupta A, Kalantar-Zadeh K. PMID: 33601392.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Of Microbiomes and Microbleeds: A New Piece of the Puzzle? Stroke. 2020 12; 51(12):3489-3491. Fisher M, Lau WL. PMID: 33148141.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Route of intestinal absorption and tissue distribution of iron contained in the novel phosphate binder ferric citrate. Nephrol Dial Transplant. 2020 07 01; 35(7):1136-1144. Vaziri ND, Nunes ACF, Said H, Khazaeli M, Liu H, Zhao Y, Jing W, Cogburn K, Alikhani L, Lau WL. PMID: 32514572.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Plant-Dominant Low-Protein Diet for Conservative Management of Chronic Kidney Disease. Nutrients. 2020 06 29; 12(7). Kalantar-Zadeh K, Joshi S, Schlueter R, Cooke J, Brown-Tortorici A, Donnelly M, Schulman S, Lau WL, Rhee CM, Streja E, Tantisattamo E, Ferrey AJ, Hanna R, Chen JLT, Malik S, Nguyen DV, Crowley ST, Kovesdy CP. PMID: 32610641.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    11. Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC): Report of a Family Pedigree. Am J Med Sci. 2020 12; 360(6):724-727. Choi G, Kimonis V, Hall K, Lau WL. PMID: 32703534.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. The consequences of altered microbiota in immune-related chronic kidney disease. Nephrol Dial Transplant. 2020 May 21. Lau WL, Chang Y, Vaziri ND. PMID: 32437554.
      View in: PubMed   Mentions: 2     Fields:    
    13. Cystatin C, cognition, and brain MRI findings in 90+-year-olds. Neurobiol Aging. 2020 09; 93:78-84. Lau WL, Fisher M, Greenia D, Floriolli D, Fletcher E, Singh B, Sajjadi SA, Corrada MM, Whittle C, Kawas C, Paganini-Hill A. PMID: 32473464.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. Development of zirconium-89 PET for in vivo imaging of alpha-klotho. Am J Nucl Med Mol Imaging. 2020; 10(2):95-105. Lau WL, Liang C, Liu H, Singh K, Mukherjee J. PMID: 32419978.
      View in: PubMed   Mentions:
    15. A Case of Novel Coronavirus Disease 19 in a Chronic Hemodialysis Patient Presenting with Gastroenteritis and Developing Severe Pulmonary Disease. Am J Nephrol. 2020; 51(5):337-342. Ferrey AJ, Choi G, Hanna RM, Chang Y, Tantisattamo E, Ivaturi K, Park E, Nguyen L, Wang B, Tonthat S, Rhee CM, Reddy U, Lau WL, Huang SS, Gohil S, Amin AN, Hsieh L, Cheng TT, Lee RA, Kalantar-Zadeh K. PMID: 32222713.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCellsPHPublic Health
    16. Hemodynamic and Laboratory Changes during Incremental Transition from Twice to Thrice-Weekly Hemodialysis. Cardiorenal Med. 2020; 10(2):97-107. Hur I, Wenziger C, Obi Y, Moradi H, Streja E, Tantisattamo E, Choi SJ, Lau WL, Chang Y, Jin A, Chen JLT, Kovesdy CP, Rhee CM, Kalantar-Zadeh K. PMID: 31935740.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Gut microbial short-chain fatty acids and the risk of diabetes. Nat Rev Nephrol. 2019 07; 15(7):389-390. Lau WL, Vaziri ND. PMID: 30918350.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man. Transl Stroke Res. 2020 02; 11(1):122-134. Lau WL, Nunes ACF, Vasilevko V, Floriolli D, Lertpanit L, Savoj J, Bangash M, Yao Z, Shah K, Naqvi S, Paganini-Hill A, Vaziri ND, Cribbs DH, Fisher M. PMID: 31055735.
      View in: PubMed   Mentions: 14     Fields:    
    19. Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease. Diseases. 2019 Feb 13; 7(1). Jazani NH, Savoj J, Lustgarten M, Lau WL, Vaziri ND. PMID: 30781823.
      View in: PubMed   Mentions:
    20. The Phosphate Binder Ferric Citrate Alters the Gut Microbiome in Rats with Chronic Kidney Disease. J Pharmacol Exp Ther. 2018 12; 367(3):452-460. Lau WL, Vaziri ND, Nunes ACF, Comeau AM, Langille MGI, England W, Khazaeli M, Suematsu Y, Phan J, Whiteson K. PMID: 30287477.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    21. Phosphate Binder, Ferric Citrate, Attenuates Anemia, Renal Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in 5/6 Nephrectomized CKD Rats. J Pharmacol Exp Ther. 2018 10; 367(1):129-137. Jing W, Nunes ACF, Farzaneh T, Khazaeli M, Lau WL, Vaziri ND. PMID: 30093458.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    22. Urine mitochondrial DNA and diabetic nephropathy-a new frontier. Nephrol Dial Transplant. 2018 05 01; 33(5):719-721. Lau WL, Lin HY, Wang PH. PMID: 29401284.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Parathyroidectomy in the Management of Secondary Hyperparathyroidism. Clin J Am Soc Nephrol. 2018 06 07; 13(6):952-961. Lau WL, Obi Y, Kalantar-Zadeh K. PMID: 29523679.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    24. Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins. Clin Sci (Lond). 2018 03 15; 132(5):509-522. Lau WL, Savoj J, Nakata MB, Vaziri ND. PMID: 29523750.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    25. Dietary tetrahydrocurcumin reduces renal fibrosis and cardiac hypertrophy in 5/6 nephrectomized rats. Pharmacol Res Perspect. 2018 04; 6(2):e00385. Lau WL, Khazaeli M, Savoj J, Manekia K, Bangash M, Thakurta RG, Dang A, Vaziri ND, Singh B. PMID: 29468071.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    26. There's no place like home: 35-year patient survival on home hemodialysis. Semin Dial. 2018 05; 31(3):300-304. Yu JZ, Rhee CM, Ferrey A, Li A, Jin A, Chang Y, Reddy U, Lau WL, Chou J, Inrig J, Kalantar-Zadeh K. PMID: 29265477.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Impact of Obesity on Modality Longevity, Residual Kidney Function, Peritonitis, and Survival Among Incident Peritoneal Dialysis Patients. Am J Kidney Dis. 2018 06; 71(6):802-813. Obi Y, Streja E, Mehrotra R, Rivara MB, Rhee CM, Soohoo M, Gillen DL, Lau WL, Kovesdy CP, Kalantar-Zadeh K. PMID: 29223620.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    28. The Leaky Gut and Altered Microbiome in Chronic Kidney Disease. J Ren Nutr. 2017 11; 27(6):458-461. Lau WL, Vaziri ND. PMID: 29056165.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    29. Warfarin Use and Increased Mortality in End-Stage Renal Disease. Am J Nephrol. 2017; 46(4):249-256. Lin MC, Streja E, Soohoo M, Hanna M, Savoj J, Kalantar-Zadeh K, Lau WL. PMID: 28910806.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Association of Parameters of Mineral Bone Disorder with Mortality in Patients on Hemodialysis according to Level of Residual Kidney Function. Clin J Am Soc Nephrol. 2017 Jul 07; 12(7):1118-1127. Wang M, Obi Y, Streja E, Rhee CM, Lau WL, Chen J, Hao C, Hamano T, Kovesdy CP, Kalantar-Zadeh K. PMID: 28487345.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. Incremental Hemodialysis: The University of California Irvine Experience. Semin Dial. 2017 05; 30(3):262-269. Ghahremani-Ghajar M, Rojas-Bautista V, Lau WL, Pahl M, Hernandez M, Jin A, Reddy U, Chou J, Obi Y, Kalantar-Zadeh K, Rhee CM. PMID: 28295607.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. Pharmacologic Blockade of avß1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo. J Am Soc Nephrol. 2017 Jul; 28(7):1998-2005. Chang Y, Lau WL, Jo H, Tsujino K, Gewin L, Reed NI, Atakilit A, Nunes ACF, DeGrado WF, Sheppard D. PMID: 28220032.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    33. Successful Peritoneal Dialysis Catheter Placement in a New End-Stage Renal Disease Patient with Combined Antiphospholipid Syndrome and Factor XI Deficiency. Adv Perit Dial. 2017 Jan; 33(2017):22-25. Ferrey A, Fujitani RM, Tran MH, Chang Y, Lau WL. PMID: 29668426.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Urea, a true uremic toxin: the empire strikes back. Clin Sci (Lond). 2017 01 01; 131(1):3-12. Lau WL, Vaziri ND. PMID: 27872172.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    35. Development and Validation of a Novel Laboratory-Specific Correction Equation for Total Serum Calcium and Its Association With Mortality Among Hemodialysis Patients. J Bone Miner Res. 2017 Mar; 32(3):549-559. Obi Y, Nguyen DV, Streja E, Rivara MB, Rhee CM, Lau WL, Chen Y, Kovesdy CP, Mehrotra R, Kalantar-Zadeh K. PMID: 27714897.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    36. Effects of end-stage renal disease and dialysis modalities on blood ammonia level. Hemodial Int. 2017 07; 21(3):343-347. Vaziri ND, Khazaeli M, Nunes ACF, Harley KT, Said H, Alipour O, Lau WL, Pahl MV. PMID: 27804262.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. The role of low protein diet in ameliorating proteinuria and deferring dialysis initiation: what is old and what is new. Panminerva Med. 2017 Jun; 59(2):157-165. Wang M, Chou J, Chang Y, Lau WL, Reddy U, Rhee CM, Chen J, Hao C, Kalantar-Zadeh K. PMID: 27759735.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    38. The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms. Transl Stroke Res. 2017 02; 8(1):67-76. Lau WL, Huisa BN, Fisher M. PMID: 27628245.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    39. Hidden Hypercalcemia and Mortality Risk in Incident Hemodialysis Patients. J Clin Endocrinol Metab. 2016 06; 101(6):2440-9. Obi Y, Mehrotra R, Rivara MB, Streja E, Rhee CM, Lau WL, Kovesdy CP, Kalantar-Zadeh K. PMID: 27045726.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    40. Changes in Markers of Mineral and Bone Disorders and Mortality in Incident Hemodialysis Patients. Am J Nephrol. 2016; 43(2):85-96. Soohoo M, Feng M, Obi Y, Streja E, Rhee CM, Lau WL, Wang J, Ravel VA, Brunelli S, Kovesdy CP, Kalantar-Zadeh K. PMID: 26950688.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    41. Resistant starch alters gut microbiome and metabolomic profiles concurrent with amelioration of chronic kidney disease in rats. Am J Physiol Renal Physiol. 2016 05 01; 310(9):F857-71. Kieffer DA, Piccolo BD, Vaziri ND, Liu S, Lau WL, Khazaeli M, Nazertehrani S, Moore ME, Marco ML, Martin RJ, Adams SH. PMID: 26841824.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
    42. Examining the robustness of the obesity paradox in maintenance hemodialysis patients: a marginal structural model analysis. Nephrol Dial Transplant. 2016 08; 31(8):1310-9. Doshi M, Streja E, Rhee CM, Park J, Ravel VA, Soohoo M, Moradi H, Lau WL, Mehrotra R, Kuttykrishnan S, Kovesdy CP, Kalantar-Zadeh K, Chen JL. PMID: 26590266.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    43. Why Is the Association of Phosphorus and FGF23 with Mortality Stronger in African-American Hemodialysis Patients. Am J Nephrol. 2015; 42(1):22-4. Lau WL, Kalantar-Zadeh K. PMID: 26288017.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. The Gut as a Source of Inflammation in Chronic Kidney Disease. Nephron. 2015; 130(2):92-8. Lau WL, Kalantar-Zadeh K, Vaziri ND. PMID: 25967288.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    45. Dietary restrictions in dialysis patients: is there anything left to eat? Semin Dial. 2015 Mar-Apr; 28(2):159-68. Kalantar-Zadeh K, Tortorici AR, Chen JL, Kamgar M, Lau WL, Moradi H, Rhee CM, Streja E, Kovesdy CP. PMID: 25649719.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    46. High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease. PLoS One. 2014; 9(12):e114881. Vaziri ND, Liu SM, Lau WL, Khazaeli M, Nazertehrani S, Farzaneh SH, Kieffer DA, Adams SH, Martin RJ. PMID: 25490712.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    47. Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption. Dig Dis Sci. 2015 May; 60(5):1215-22. Lau WL, Liu SM, Pahlevan S, Yuan J, Khazaeli M, Ni Z, Chan JY, Vaziri ND. PMID: 25399330.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    48. Cerebral microbleeds and cognitive decline in a hemodialysis patient: Case report and review of literature. Hemodial Int. 2015 Jul; 19(3):E1-7. Li L, Fisher M, Lau WL, Moradi H, Cheung A, Thai G, Handwerker J, Kalantar-Zadeh K. PMID: 25175449.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    49. Chronic kidney disease results in deficiency of ABCC6, the novel inhibitor of vascular calcification. Am J Nephrol. 2014; 40(1):51-5. Lau WL, Liu S, Vaziri ND. PMID: 24994603.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    50. Towards the revival of alkaline phosphatase for the management of bone disease, mortality and hip fractures. Nephrol Dial Transplant. 2014 Aug; 29(8):1450-2. Lau WL, Kalantar-Zadeh K. PMID: 24737443.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    51. Impact of age, race and ethnicity on dialysis patient survival and kidney transplantation disparities. Am J Nephrol. 2014; 39(3):183-94. Rhee CM, Lertdumrongluk P, Streja E, Park J, Moradi H, Lau WL, Norris KC, Nissenson AR, Amin AN, Kovesdy CP, Kalantar-Zadeh K. PMID: 24556752.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    52. Mortality of combined serum phosphorus and parathyroid hormone concentrations and their changes over time in hemodialysis patients. Bone. 2014 Apr; 61:201-7. Streja E, Wang HY, Lau WL, Molnar MZ, Kovesdy CP, Kalantar-Zadeh K, Park J. PMID: 24486956.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    53. Risk of chronic kidney disease after cancer nephrectomy. Nat Rev Nephrol. 2014 Mar; 10(3):135-45. Li L, Lau WL, Rhee CM, Harley K, Kovesdy CP, Sim JJ, Jacobsen S, Chang A, Landman J, Kalantar-Zadeh K. PMID: 24419566.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    54. Comparative mortality-predictability using alkaline phosphatase and parathyroid hormone in patients on peritoneal dialysis and hemodialysis. Perit Dial Int. 2014 Nov-Dec; 34(7):732-48. Rhee CM, Molnar MZ, Lau WL, Ravel V, Kovesdy CP, Mehrotra R, Kalantar-Zadeh K. PMID: 24385335.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    55. Hyperphosphatemia is a combined function of high serum PTH and high dietary protein intake in dialysis patients. Kidney Int Suppl (2011). 2013 Dec; 3(5):462-468. Streja E, Lau WL, Goldstein L, Sim JJ, Molnar MZ, Nissenson AR, Kovesdy CP, Kalantar-Zadeh K. PMID: 25019031.
      View in: PubMed   Mentions:
    56. Association of serum phosphorus concentration with mortality in elderly and nonelderly hemodialysis patients. J Ren Nutr. 2013 Nov; 23(6):411-21. Lertdumrongluk P, Rhee CM, Park J, Lau WL, Moradi H, Jing J, Molnar MZ, Brunelli SM, Nissenson AR, Kovesdy CP, Kalantar-Zadeh K. PMID: 23631888.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
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