Reginald McNulty

Title(s)	Assistant Professor, Molecular Biology & Biochemistry
School	School of Biological Sciences
Address	Irvine CA 92697
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Research

research activities and funding

Macromolecular assemblies of transcription factors initiated by pathogen infection
NIH K22AI139444Aug 22, 2019 - Nov 30, 2021
Role: Principal Investigator

Structural studies of bacteriophage genome packaging and ejection
NIH F32GM108310Apr 1, 2014 - Mar 31, 2017
Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Targeting the NLRP3 inflammasome for inflammatory disease therapy. Trends Pharmacol Sci. 2025 May 14. Cabral JE, Wu A, Zhou H, Pham MA, Lin S, McNulty R. PMID: 40374417.

View in: PubMed Mentions: Fields:
Pha Pharmacology
NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence Regulation. bioRxiv. 2025 Mar 12. Cabral JE, Lin S, Zhou H, Wu A, Lackner A, Pham MA, Chi F, McNulty R. PMID: 40161730; PMCID: PMC11952316.

View in: PubMed Mentions:
Variable Assembly and Procapsid Binding of Bacteriophage P22 Terminase Subunits in Solution. Pathogens. 2024 Dec 03; 13(12). Cabral JE, Qiu Y, Heck AJR, McNulty R. PMID: 39770326; PMCID: PMC11728703.

View in: PubMed Mentions: Translation:Cells
Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation. iScience. 2024 Aug 16; 27(8):110459. Lackner A, Cabral JE, Qiu Y, Zhou H, Leonidas L, Pham MA, Macapagal A, Lin S, Armanus E, McNulty R. PMID: 39104412; PMCID: PMC11298654.

View in: PubMed Mentions: 2
Measuring Interactions Between Proteins and Small Molecules or Nucleic Acids. Curr Protoc. 2024 Jul; 4(7):e1105. Lackner A, Qiu Y, Armanus E, Macapagal ANK, Leonidas L, Xu H, McNulty R. PMID: 39040024; PMCID: PMC11335060.

View in: PubMed Mentions: 1 Fields:
Sci Science
Translation:Humans Cells
Small molecule inhibitor binds to NLRP3 and prevents inflammasome activation. bioRxiv. 2023 Dec 14. Lackner A, Cabral JE, Qiu Y, Zhou H, Leonidas L, Pham MA, Macapagal A, Lin S, Armanus E, McNulty R. PMID: 38168343; PMCID: PMC10760093.

View in: PubMed Mentions:
Author Correction: Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Commun Biol. 2023 Jun 12; 6(1):632. Cabral A, Cabral JE, Wang A, Zhang Y, Liang H, Nikbakht D, Corona L, Hoffman HM, McNulty R. PMID: 37308785; PMCID: PMC10260916.

View in: PubMed Mentions: 1
Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Commun Biol. 2023 05 30; 6(1):578. Cabral A, Cabral JE, Wang A, Zhang Y, Liang H, Nikbakht D, Corona L, Hoffman HM, McNulty R. PMID: 37253813; PMCID: PMC10229695.

View in: PubMed Mentions: 13 Translation:Humans Cells
Cryo-EM for Small Molecules. Curr Protoc. 2022 Dec; 2(12):e632. Cabral A, Cabral JE, McNulty R. PMID: 36511652; PMCID: PMC11245322.

View in: PubMed Mentions: 4 Fields:
Sci Science
Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596; PMCID: PMC8018782.

View in: PubMed Mentions: 123 Fields:
Met Metabolism
Translation:Humans Animals Cells
Cryo-EM Elucidation of the Structure of Bacteriophage P22 Virions after Genome Release. Biophys J. 2018 03 27; 114(6):1295-1301. McNulty R, Cardone G, Gilcrease EB, Baker TS, Casjens SR, Johnson JE. PMID: 29590587; PMCID: PMC5883611.

View in: PubMed Mentions: 11 Fields:
Bio Biophysics
Translation:Cells
Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. J Mol Biol. 2015 Oct 09; 427(20):3285-3299. McNulty R, Lokareddy RK, Roy A, Yang Y, Lander GC, Heck AJR, Johnson JE, Cingolani G. PMID: 26301600; PMCID: PMC4587339.

View in: PubMed Mentions: 22 Fields:
Mol Molecular Biology
Translation:Cells
Mechanisms of molecular transport through the urea channel of Helicobacter pylori. Nat Commun. 2013; 4:2900. McNulty R, Ulmschneider JP, Luecke H, Ulmschneider MB. PMID: 24305683; PMCID: PMC3863980.

View in: PubMed Mentions: 17 Fields:
Bio Biology Sci Science
Translation:Cells
Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori. Nature. 2013 Jan 10; 493(7431):255-8. Strugatsky D, McNulty R, Munson K, Chen CK, Soltis SM, Sachs G, Luecke H. PMID: 23222544; PMCID: PMC3974264.

View in: PubMed Mentions: 37 Fields:
Sci Science
Translation:Cells
Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9449-54. Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. PMID: 21606338; PMCID: PMC3111320.

View in: PubMed Mentions: 87 Fields:
Sci Science
Translation:Cells