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Reginald McNulty

Title(s)Assistant Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
AddressIrvine CA 92697
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    Collapse Research 
    Collapse research activities and funding
    Macromolecular assemblies of transcription factors initiated by pathogen infection
    NIH K22AI139444Aug 22, 2019 - Nov 30, 2021
    Role: Principal Investigator
    Structural studies of bacteriophage genome packaging and ejection
    NIH F32GM108310Apr 1, 2014 - Mar 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. How interactions between oxidized DNA and the NLRP3 inflammasome fuel inflammatory disease. Trends Biochem Sci. 2025 Aug 28. Lackner A, Leonidas L, Macapagal A, Lee H, McNulty R. PMID: 40883132.
      View in: PubMed   Mentions:    Fields:    
    2. TH5487 specifically targets NLRP3 in FCAS patients resistant to MCC950. bioRxiv. 2025 Jun 08. Lackner A, Leonidas L, Macapagal A, Lee H, Xu H, Qiu Y, Campos M, Cabral JE, Onyuru J, Kulkarni S, Albrecht LV, Hoffman HM, McNulty R. PMID: 40661406; PMCID: PMC12258936.
      View in: PubMed   Mentions:
    3. Targeting the NLRP3 inflammasome for inflammatory disease therapy. Trends Pharmacol Sci. 2025 06; 46(6):503-519. Cabral JE, Wu A, Zhou H, Pham MA, Lin S, McNulty R. PMID: 40374417.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    4. NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence Regulation. bioRxiv. 2025 Mar 12. Cabral JE, Lin S, Zhou H, Wu A, Lackner A, Pham MA, Chi F, McNulty R. PMID: 40161730; PMCID: PMC11952316.
      View in: PubMed   Mentions:
    5. Variable Assembly and Procapsid Binding of Bacteriophage P22 Terminase Subunits in Solution. Pathogens. 2024 Dec 03; 13(12). Cabral JE, Qiu Y, Heck AJR, McNulty R. PMID: 39770326; PMCID: PMC11728703.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation. iScience. 2024 Aug 16; 27(8):110459. Lackner A, Cabral JE, Qiu Y, Zhou H, Leonidas L, Pham MA, Macapagal A, Lin S, Armanus E, McNulty R. PMID: 39104412; PMCID: PMC11298654.
      View in: PubMed   Mentions: 4  
    7. Measuring Interactions Between Proteins and Small Molecules or Nucleic Acids. Curr Protoc. 2024 Jul; 4(7):e1105. Lackner A, Qiu Y, Armanus E, Macapagal ANK, Leonidas L, Xu H, McNulty R. PMID: 39040024; PMCID: PMC11335060.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Small molecule inhibitor binds to NLRP3 and prevents inflammasome activation. bioRxiv. 2023 Dec 14. Lackner A, Cabral JE, Qiu Y, Zhou H, Leonidas L, Pham MA, Macapagal A, Lin S, Armanus E, McNulty R. PMID: 38168343; PMCID: PMC10760093.
      View in: PubMed   Mentions:
    9. Author Correction: Differential binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Commun Biol. 2023 Jun 12; 6(1):632. Cabral A, Cabral JE, Wang A, Zhang Y, Liang H, Nikbakht D, Corona L, Hoffman HM, McNulty R. PMID: 37308785; PMCID: PMC10260916.
      View in: PubMed   Mentions: 1  
    10. Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation. Commun Biol. 2023 05 30; 6(1):578. Cabral A, Cabral JE, Wang A, Zhang Y, Liang H, Nikbakht D, Corona L, Hoffman HM, McNulty R. PMID: 37253813; PMCID: PMC10229695.
      View in: PubMed   Mentions: 15  Translation:HumansCells
    11. Cryo-EM for Small Molecules. Curr Protoc. 2022 Dec; 2(12):e632. Cabral A, Cabral JE, McNulty R. PMID: 36511652; PMCID: PMC11245322.
      View in: PubMed   Mentions: 4     Fields:    
    12. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nat Metab. 2020 10; 2(10):1034-1045. Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. PMID: 32839596; PMCID: PMC8018782.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    13. Cryo-EM Elucidation of the Structure of Bacteriophage P22 Virions after Genome Release. Biophys J. 2018 03 27; 114(6):1295-1301. McNulty R, Cardone G, Gilcrease EB, Baker TS, Casjens SR, Johnson JE. PMID: 29590587; PMCID: PMC5883611.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    14. Structural characterization of the ternary complex that mediates termination of NF-κB signaling by IκBα. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6212-7. Mukherjee SP, Quintas PO, McNulty R, Komives EA, Dyson HJ. PMID: 27185953; PMCID: PMC4896678.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22. J Mol Biol. 2015 Oct 09; 427(20):3285-3299. McNulty R, Lokareddy RK, Roy A, Yang Y, Lander GC, Heck AJR, Johnson JE, Cingolani G. PMID: 26301600; PMCID: PMC4587339.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    16. Mechanisms of molecular transport through the urea channel of Helicobacter pylori. Nat Commun. 2013; 4:2900. McNulty R, Ulmschneider JP, Luecke H, Ulmschneider MB. PMID: 24305683; PMCID: PMC3863980.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    17. Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori. Nature. 2013 Jan 10; 493(7431):255-8. Strugatsky D, McNulty R, Munson K, Chen CK, Soltis SM, Sachs G, Luecke H. PMID: 23222544; PMCID: PMC3974264.
      View in: PubMed   Mentions: 48     Fields:    Translation:Cells
    18. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein. Proc Natl Acad Sci U S A. 2011 Jun 07; 108(23):9449-54. Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. PMID: 21606338; PMCID: PMC3111320.
      View in: PubMed   Mentions: 98     Fields:    Translation:Cells
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