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Angela Goffredo Fleischman

Title(s)Associate Professor, Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2559
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial. Blood Adv. 2020 Sep 22; 4(18):4282-4291. Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O'Connell C, Arcasoy MO, Zhang Y, Kawashima J, Ganz T, Kowalski M, Brachmann CB. PMID: 32915978.
      View in: PubMed   Mentions:    Fields:    
    2. E-Cigarette Exposure Decreases Bone Marrow Hematopoietic Progenitor Cells. Cancers (Basel). 2020 Aug 14; 12(8). Ramanathan G, Craver-Hoover B, Arechavala RJ, Herman DA, Chen JH, Lai HY, Renusch SR, Kleinman MT, Fleischman AG. PMID: 32824092.
      View in: PubMed   Mentions:
    3. Impact of Host, Lifestyle and Environmental Factors in the Pathogenesis of MPN. Cancers (Basel). 2020 Jul 24; 12(8). Ramanathan G, Hoover BM, Fleischman AG. PMID: 32722135.
      View in: PubMed   Mentions:
    4. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. Nat Commun. 2020 06 12; 11(1):2971. Jalili P, Bowen D, Langenbucher A, Park S, Aguirre K, Corcoran RB, Fleischman AG, Lawrence MS, Zou L, Buisson R. PMID: 32532990.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis. Blood. 2020 May 07; 135(19):1696-1703. Ronner L, Podoltsev N, Gotlib J, Heaney ML, Kuykendall AT, O'Connell C, Shammo J, Fleischman AG, Scherber RM, Mesa R, Yacoub A, Perkins C, Meckstroth S, Behlman L, Chiaramonte M, Salehi M, Ziadkhanpour K, Nguyen H, Siwoski O, Hung AK, Janania Martinez M, Nguyen J, Patel S, Kollipara R, Dave A, Randall M, Grant M, Harrison M, Fernandez Soto P, Tremblay D, Hoffman R, Moshier E, Mascarenhas J. PMID: 32107559.
      View in: PubMed   Mentions:    Fields:    
    6. N-acetylcysteine inhibits thrombosis in a murine model of myeloproliferative neoplasm. Blood Adv. 2020 Jan 28; 4(2):312-321. Craver BM, Ramanathan G, Hoang S, Chang X, Mendez Luque LF, Brooks S, Lai HY, Fleischman AG. PMID: 31978215.
      View in: PubMed   Mentions: 4     Fields:    
    7. The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells. Exp Hematol Oncol. 2020; 9:1. Craver BM, Nguyen TK, Nguyen J, Nguyen H, Huynh C, Morse SJ, Fleischman AG. PMID: 31908904.
      View in: PubMed   Mentions:
    8. Key Role of Inflammation in Myeloproliferative Neoplasms: Instigator of Disease Initiation, Progression. and Symptoms. Curr Hematol Malig Rep. 2019 06; 14(3):145-153. Mendez Luque LF, Blackmon AL, Ramanathan G, Fleischman AG. PMID: 31119475.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation. Leuk Res. 2019 07; 82:11-14. Brooks SA, Kim DM, Morse SJ, Nguyen QH, Craver BM, Lai HY, Fleischman AG. PMID: 31128484.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Defective negative regulation of Toll-like receptor signaling leads to excessive TNF-a in myeloproliferative neoplasm. Blood Adv. 2019 01 22; 3(2):122-131. Lai HY, Brooks SA, Craver BM, Morse SJ, Nguyen TK, Haghighi N, Garbati MR, Fleischman AG. PMID: 30647074.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy. Oncotarget. 2018 Sep 07; 9(70):33416-33439. Singer JW, Fleischman A, Al-Fayoumi S, Mascarenhas JO, Yu Q, Agarwal A. PMID: 30279971.
      View in: PubMed   Mentions: 10     Fields:    
    12. Statins enhance efficacy of venetoclax in blood cancers. Sci Transl Med. 2018 06 13; 10(445). Lee JS, Roberts A, Juarez D, Vo TT, Bhatt S, Herzog LO, Mallya S, Bellin RJ, Agarwal SK, Salem AH, Xu T, Jia J, Li L, Hanna JR, Davids MS, Fleischman AG, O'Brien S, Lam LT, Leverson JD, Letai A, Schatz JH, Fruman DA. PMID: 29899021.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    13. The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies. Cancers (Basel). 2018 Apr 03; 10(4). Craver BM, El Alaoui K, Scherber RM, Fleischman AG. PMID: 29614027.
      View in: PubMed   Mentions:
    14. Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms. J Theor Biol. 2017 07 21; 425:43-52. Zhang J, Fleischman AG, Wodarz D, Komarova NL. PMID: 28501635.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm. J Vis Exp. 2016 12 22; (118). Nguyen TK, Morse SJ, Fleischman AG. PMID: 28060252.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    16. JAK2(V617I) results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model. Exp Hematol. 2016 Jan; 44(1):24-9.e1. Brooks SA, Luty SB, Lai HY, Morse SJ, Nguyen TK, Royer LR, Agarwal A, Druker BJ, Fleischman AG. PMID: 26458983.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    17. Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm. Mediators Inflamm. 2015; 2015:606819. Fleischman AG. PMID: 26538830.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Chronic inflammation: is it the driver or is it paving the road for malignant transformation? Genes Cancer. 2015 May; 6(5-6):214-9. Afrasiabi K, Zhou YH, Fleischman A. PMID: 26124920.
      View in: PubMed   Mentions:
    19. BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein. Blood. 2014 Nov 20; 124(22):3260-73. Agarwal A, Mackenzie RJ, Besson A, Jeng S, Carey A, LaTocha DH, Fleischman AG, Duquesnes N, Eide CA, Vasudevan KB, Loriaux MM, Firpo E, Cortes JE, McWeeney S, O'Hare T, Roberts JM, Druker BJ, Deininger MW. PMID: 25293778.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. Causal role for JAK2 V617F in thrombosis. Blood. 2013 Nov 28; 122(23):3705-6. Fleischman AG, Tyner JW. PMID: 24288407.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Blood. 2013 Nov 21; 122(22):3628-31. Fleischman AG, Maxson JE, Luty SB, Agarwal A, Royer LR, Abel ML, MacManiman JD, Loriaux MM, Druker BJ, Tyner JW. PMID: 24081659.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    22. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med. 2013 May 09; 368(19):1781-90. Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW. PMID: 23656643.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    23. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77. Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT. PMID: 23471820.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    24. Hematopoietic stem cell transplantation for myelofibrosis: where are we now? Curr Opin Hematol. 2013 Mar; 20(2):130-6. Fleischman AG, Maziarz RT. PMID: 23314844.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    25. Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML. Blood. 2012 Sep 27; 120(13):2658-68. Agarwal A, Fleischman AG, Petersen CL, MacKenzie R, Luty S, Loriaux M, Druker BJ, Woltjer RL, Deininger MW. PMID: 22889761.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    26. JAK2 V617F down-modulates MPL. Blood. 2012 May 17; 119(20):4579-80. Fleischman AG, Tyner JW. PMID: 22596167.
      View in: PubMed   Mentions:    Fields:    
    27. ALDH marks leukemia stem cell. Blood. 2012 Apr 12; 119(15):3376-7. Fleischman AG. PMID: 22500050.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    28. TNFa facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms. Blood. 2011 Dec 08; 118(24):6392-8. Fleischman AG, Aichberger KJ, Luty SB, Bumm TG, Petersen CL, Doratotaj S, Vasudevan KB, LaTocha DH, Yang F, Press RD, Loriaux MM, Pahl HL, Silver RT, Agarwal A, O'Hare T, Druker BJ, Bagby GC, Deininger MW. PMID: 21860020.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    29. The stem cell fitness landscape and pathways of molecular leukemogenesis. Front Biosci (Schol Ed). 2011 Jan 01; 3:487-500. Bagby GC, Fleischman AG. PMID: 21196392.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    30. Same mutation, different allele. Blood. 2009 Oct 01; 114(14):2853-4. Aichberger KJ, Fleischman AG, Deininger MW. PMID: 19797527.
      View in: PubMed   Mentions:    Fields:    
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