Angela Goffredo Fleischman

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2559
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Results from a Randomized Phase I Pilot Study for Feasibility and Adherence. Cancer Res Commun. 2024 03 05; 4(3):660-670. Mendez Luque LF, Avelar-Barragan J, Nguyen H, Nguyen J, Soyfer EM, Liu J, Chen JH, Mehrotra N, Huang X, Kosiorek HE, Dueck A, Himstead A, Heide E, Lem M, El Alaoui K, Mas E, Scherber RM, Mesa RA, Whiteson KL, Odegaard A, Fleischman AG. PMID: 38391189; PMCID: PMC10913729.
      View in: PubMed   Mentions: Translation:HumansCTClinical Trials
    2. HyperCVAD versus pegaspargase-containing regimens for Hispanic adults with newly diagnosed B-cell acute lymphoblastic leukemia. Eur J Haematol. 2024 Mar; 112(3):392-401. Lee BJ, Griffin SP, Doh J, Chan A, Ciurea SO, Jeyakumar D, Fleischman AG, Naqvi K, Pannunzio NR, O'Brien S, Kongtim P. PMID: 37933194.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Characterizing the microbiome of patients with myeloproliferative neoplasms during a Mediterranean diet intervention. mBio. 2023 Oct 25; e0230823. Avelar-Barragan J, Mendez Luque LF, Nguyen J, Nguyen H, Odegaard AO, Fleischman AG, Whiteson KL. PMID: 37877698; PMCID: PMC10746218.
      View in: PubMed   Mentions:    Fields:    
    4. Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities. Res Sq. 2023 Sep 11. Pannunzio N, Rangel V, Sterrenberg J, Garawi A, Mezcord V, Folkerts M, Caulderon S, Wang J, Soyfer E, Eng O, Valerin J, Tanjasiri S, Quintero-Rivera F, Masri S, Seldin M, Frock R, Fleischman A. PMID: 37790327; PMCID: PMC10543404.
      View in: PubMed   Mentions:
    5. Cigarette smoke stimulates clonal expansion of Jak2V617F and Tet2-/- cells. Front Oncol. 2023; 13:1210528. Ramanathan G, Chen JH, Mehrotra N, Trieu T, Huang A, Mas E, Monterrosa Mena JE, Bliss B, Herman DA, Kleinman MT, Fleischman AG. PMID: 37546389; PMCID: PMC10401270.
      View in: PubMed   Mentions:
    6. Myeloproliferative neoplasms - blurring the lines between cancer and chronic inflammatory disorder. Front Oncol. 2023; 13:1208089. Soyfer EM, Fleischman AG. PMID: 37361587; PMCID: PMC10288874.
      View in: PubMed   Mentions: 1  
    7. The NUTRIENT Trial (NUTRitional Intervention among myEloproliferative Neoplasms): Feasibility Phase. medRxiv. 2023 May 12. Mendez Luque LF, Avelar-Barragan J, Nguyen H, Nguyen J, Soyfer EM, Liu J, Chen JH, Mehrotra N, Kosiorek HE, Dueck A, Himstead A, Heide E, Lem M, Alaoui KE, Marin EM, Scherber RM, Mesa RA, Whiteson KL, Odegaard A, Fleischman AG. PMID: 37214789; PMCID: PMC10197802.
      View in: PubMed   Mentions:
    8. Ten years after ruxolitinib approval for myelofibrosis: a review of clinical efficacy. Leuk Lymphoma. 2023 06; 64(6):1063-1081. Pemmaraju N, Bose P, Rampal R, Gerds AT, Fleischman A, Verstovsek S. PMID: 37081809.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    9. Quality of life independently predicts overall survival in myelofibrosis: Key insights from the COntrolled MyeloFibrosis Study with ORal Janus kinase inhibitor Treatment (COMFORT)-I study. Br J Haematol. 2022 09; 198(6):1065-1068. Kosiorek HE, Scherber RM, Geyer HL, Verstovsek S, Langlais BT, Mazza GL, Gotlib J, Gupta V, Padrnos LJ, Palmer JM, Fleischman A, Mesa RA, Dueck AC. PMID: 35751150.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Anagrelide for platelet-directed cytoreduction in polycythemia vera: Insights into utility and safety outcomes from a large multi-center database. Leuk Res. 2022 08; 119:106903. Rippel N, Tremblay D, Zubizarreta N, Podoltsev N, Gotlib J, Heaney M, Kuykendall A, O'Connell C, Shammo JM, Fleischman A, Kremyanskaya M, Hoffman R, Mesa R, Yacoub A, Mascarenhas J. PMID: 35717689.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. European LeukemiaNet Response Predicts Disease Progression but Not Thrombosis in Polycythemia Vera. Hemasphere. 2022 Jun; 6(6):e721. Tremblay D, Srisuwananukorn A, Ronner L, Podoltsev N, Gotlib J, Heaney ML, Kuykendall A, O'Connell CL, Shammo JM, Fleischman A, Mesa R, Yacoub A, Hoffman R, Moshier E, Zubizarreta N, Mascarenhas J. PMID: 35747843; PMCID: PMC9208865.
      View in: PubMed   Mentions: 4  
    12. Fecal Microbial Community Composition in Myeloproliferative Neoplasm Patients Is Associated with an Inflammatory State. Microbiol Spectr. 2022 06 29; 10(3):e0003222. Oliver A, El Alaoui K, Haunschild C, Avelar-Barragan J, Mendez Luque LF, Whiteson K, Fleischman AG. PMID: 35475626; PMCID: PMC9241690.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    13. Inflammation in Myeloid Malignancies: From Bench to Bedside. J Immunother Precis Oncol. 2021 Aug; 4(3):160-167. Soyfer EM, Fleischman AG. PMID: 35663100; PMCID: PMC9138438.
      View in: PubMed   Mentions: 5  
    14. Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity. EMBO Mol Med. 2021 08 09; 13(8):e13086. Jayashankar V, Selwan E, Hancock SE, Verlande A, Goodson MO, Eckenstein KH, Milinkeviciute G, Hoover BM, Chen B, Fleischman AG, Cramer KS, Hanessian S, Masri S, Turner N, Edinger AL. PMID: 34231322; PMCID: PMC8350895.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    15. Ruxolitinib discontinuation in polycythemia vera: Patient characteristics, outcomes, and salvage strategies from a large multi-institutional database. Leuk Res. 2021 10; 109:106629. Tremblay D, Ronner L, Podoltsev N, Gotlib J, Heaney M, Kuykendall A, O'Connell C, Shammo JM, Fleischman A, Mesa R, Yacoub A, Hoffman R, Moshier E, Zubizarreta N, Mascarenhas J. PMID: 34082375.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. The Microenvironment in Myeloproliferative Neoplasms. Hematol Oncol Clin North Am. 2021 04; 35(2):205-216. Ramanathan G, Fleischman AG. PMID: 33641864; PMCID: PMC8832361.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. ACVR1/JAK1/JAK2 inhibitor momelotinib reverses transfusion dependency and suppresses hepcidin in myelofibrosis phase 2 trial. Blood Adv. 2020 09 22; 4(18):4282-4291. Oh ST, Talpaz M, Gerds AT, Gupta V, Verstovsek S, Mesa R, Miller CB, Rivera CE, Fleischman AG, Goel S, Heaney ML, O'Connell C, Arcasoy MO, Zhang Y, Kawashima J, Ganz T, Kowalski M, Brachmann CB. PMID: 32915978; PMCID: PMC7509854.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    18. E-Cigarette Exposure Decreases Bone Marrow Hematopoietic Progenitor Cells. Cancers (Basel). 2020 Aug 14; 12(8). Ramanathan G, Craver-Hoover B, Arechavala RJ, Herman DA, Chen JH, Lai HY, Renusch SR, Kleinman MT, Fleischman AG. PMID: 32824092; PMCID: PMC7464997.
      View in: PubMed   Mentions: 4  
    19. Impact of Host, Lifestyle and Environmental Factors in the Pathogenesis of MPN. Cancers (Basel). 2020 Jul 24; 12(8). Ramanathan G, Hoover BM, Fleischman AG. PMID: 32722135; PMCID: PMC7463688.
      View in: PubMed   Mentions: 6  
    20. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. Nat Commun. 2020 06 12; 11(1):2971. Jalili P, Bowen D, Langenbucher A, Park S, Aguirre K, Corcoran RB, Fleischman AG, Lawrence MS, Zou L, Buisson R. PMID: 32532990; PMCID: PMC7293259.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    21. Persistent leukocytosis in polycythemia vera is associated with disease evolution but not thrombosis. Blood. 2020 05 07; 135(19):1696-1703. Ronner L, Podoltsev N, Gotlib J, Heaney ML, Kuykendall AT, O'Connell C, Shammo J, Fleischman AG, Scherber RM, Mesa R, Yacoub A, Perkins C, Meckstroth S, Behlman L, Chiaramonte M, Salehi M, Ziadkhanpour K, Nguyen H, Siwoski O, Hung AK, Janania Martinez M, Nguyen J, Patel S, Kollipara R, Dave A, Randall M, Grant M, Harrison M, Fernandez Soto P, Tremblay D, Hoffman R, Moshier E, Mascarenhas J. PMID: 32107559; PMCID: PMC7205813.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    22. N-acetylcysteine inhibits thrombosis in a murine model of myeloproliferative neoplasm. Blood Adv. 2020 01 28; 4(2):312-321. Craver BM, Ramanathan G, Hoang S, Chang X, Mendez Luque LF, Brooks S, Lai HY, Fleischman AG. PMID: 31978215; PMCID: PMC6988398.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    23. The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells. Exp Hematol Oncol. 2020; 9:1. Craver BM, Nguyen TK, Nguyen J, Nguyen H, Huynh C, Morse SJ, Fleischman AG. PMID: 31908904; PMCID: PMC6941266.
      View in: PubMed   Mentions: 7  
    24. Key Role of Inflammation in Myeloproliferative Neoplasms: Instigator of Disease Initiation, Progression. and Symptoms. Curr Hematol Malig Rep. 2019 06; 14(3):145-153. Mendez Luque LF, Blackmon AL, Ramanathan G, Fleischman AG. PMID: 31119475; PMCID: PMC7746200.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    25. Upregulation of endogenous thrombopoietin receptor (MPL) with in vivo passage of calreticulin (CALR) mutant Ba/F3 cells, highlighting MPL as the requisite cytokine receptor for CALR mediated transformation. Leuk Res. 2019 07; 82:11-14. Brooks SA, Kim DM, Morse SJ, Nguyen QH, Craver BM, Lai HY, Fleischman AG. PMID: 31128484; PMCID: PMC8843802.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    26. Defective negative regulation of Toll-like receptor signaling leads to excessive TNF-α in myeloproliferative neoplasm. Blood Adv. 2019 01 22; 3(2):122-131. Lai HY, Brooks SA, Craver BM, Morse SJ, Nguyen TK, Haghighi N, Garbati MR, Fleischman AG. PMID: 30647074; PMCID: PMC6341195.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    27. Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy. Oncotarget. 2018 Sep 07; 9(70):33416-33439. Singer JW, Fleischman A, Al-Fayoumi S, Mascarenhas JO, Yu Q, Agarwal A. PMID: 30279971; PMCID: PMC6161786.
      View in: PubMed   Mentions: 57     Fields:    
    28. Statins enhance efficacy of venetoclax in blood cancers. Sci Transl Med. 2018 06 13; 10(445). Lee JS, Roberts A, Juarez D, Vo TT, Bhatt S, Herzog LO, Mallya S, Bellin RJ, Agarwal SK, Salem AH, Xu T, Jia J, Li L, Hanna JR, Davids MS, Fleischman AG, O'Brien S, Lam LT, Leverson JD, Letai A, Schatz JH, Fruman DA. PMID: 29899021; PMCID: PMC6336198.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    29. The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies. Cancers (Basel). 2018 Apr 03; 10(4). Craver BM, El Alaoui K, Scherber RM, Fleischman AG. PMID: 29614027; PMCID: PMC5923359.
      View in: PubMed   Mentions: 41  
    30. Determining the role of inflammation in the selection of JAK2 mutant cells in myeloproliferative neoplasms. J Theor Biol. 2017 07 21; 425:43-52. Zhang J, Fleischman AG, Wodarz D, Komarova NL. PMID: 28501635; PMCID: PMC5689470.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm. J Vis Exp. 2016 12 22; (118). Nguyen TK, Morse SJ, Fleischman AG. PMID: 28060252; PMCID: PMC5226441.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    32. JAK2(V617I) results in cytokine hypersensitivity without causing an overt myeloproliferative disorder in a mouse transduction-transplantation model. Exp Hematol. 2016 Jan; 44(1):24-9.e1. Brooks SA, Luty SB, Lai HY, Morse SJ, Nguyen TK, Royer LR, Agarwal A, Druker BJ, Fleischman AG. PMID: 26458983; PMCID: PMC5685804.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    33. Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm. Mediators Inflamm. 2015; 2015:606819. Fleischman AG. PMID: 26538830; PMCID: PMC4619974.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    34. Chronic inflammation: is it the driver or is it paving the road for malignant transformation? Genes Cancer. 2015 May; 6(5-6):214-9. Afrasiabi K, Zhou YH, Fleischman A. PMID: 26124920; PMCID: PMC4482242.
      View in: PubMed   Mentions: 4  
    35. BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein. Blood. 2014 Nov 20; 124(22):3260-73. Agarwal A, Mackenzie RJ, Besson A, Jeng S, Carey A, LaTocha DH, Fleischman AG, Duquesnes N, Eide CA, Vasudevan KB, Loriaux MM, Firpo E, Cortes JE, McWeeney S, O'Hare T, Roberts JM, Druker BJ, Deininger MW. PMID: 25293778; PMCID: PMC4239335.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    36. Causal role for JAK2 V617F in thrombosis. Blood. 2013 Nov 28; 122(23):3705-6. Fleischman AG, Tyner JW. PMID: 24288407; PMCID: PMC3843232.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    37. The CSF3R T618I mutation causes a lethal neutrophilic neoplasia in mice that is responsive to therapeutic JAK inhibition. Blood. 2013 Nov 21; 122(22):3628-31. Fleischman AG, Maxson JE, Luty SB, Agarwal A, Royer LR, Abel ML, MacManiman JD, Loriaux MM, Druker BJ, Tyner JW. PMID: 24081659; PMCID: PMC3837511.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    38. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med. 2013 May 09; 368(19):1781-90. Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW. PMID: 23656643; PMCID: PMC3730275.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimalsCells
    39. TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov. 2013 May; 3(5):564-77. Sanda T, Tyner JW, Gutierrez A, Ngo VN, Glover J, Chang BH, Yost A, Ma W, Fleischman AG, Zhou W, Yang Y, Kleppe M, Ahn Y, Tatarek J, Kelliher MA, Neuberg DS, Levine RL, Moriggl R, Müller M, Gray NS, Jamieson CH, Weng AP, Staudt LM, Druker BJ, Look AT. PMID: 23471820; PMCID: PMC3651770.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    40. Hematopoietic stem cell transplantation for myelofibrosis: where are we now? Curr Opin Hematol. 2013 Mar; 20(2):130-6. Fleischman AG, Maziarz RT. PMID: 23314844.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Effects of plerixafor in combination with BCR-ABL kinase inhibition in a murine model of CML. Blood. 2012 Sep 27; 120(13):2658-68. Agarwal A, Fleischman AG, Petersen CL, MacKenzie R, Luty S, Loriaux M, Druker BJ, Woltjer RL, Deininger MW. PMID: 22889761; PMCID: PMC3460687.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    42. JAK2 V617F down-modulates MPL. Blood. 2012 May 17; 119(20):4579-80. Fleischman AG, Tyner JW. PMID: 22596167.
      View in: PubMed   Mentions: 1     Fields:    
    43. ALDH marks leukemia stem cell. Blood. 2012 Apr 12; 119(15):3376-7. Fleischman AG. PMID: 22500050.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    44. TNFα facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms. Blood. 2011 Dec 08; 118(24):6392-8. Fleischman AG, Aichberger KJ, Luty SB, Bumm TG, Petersen CL, Doratotaj S, Vasudevan KB, LaTocha DH, Yang F, Press RD, Loriaux MM, Pahl HL, Silver RT, Agarwal A, O'Hare T, Druker BJ, Bagby GC, Deininger MW. PMID: 21860020; PMCID: PMC3236121.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    45. The stem cell fitness landscape and pathways of molecular leukemogenesis. Front Biosci (Schol Ed). 2011 01 01; 3(2):487-500. Bagby GC, Fleischman AG. PMID: 21196392.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    46. Same mutation, different allele. Blood. 2009 Oct 01; 114(14):2853-4. Aichberger KJ, Fleischman AG, Deininger MW. PMID: 19797527.
      View in: PubMed   Mentions:    Fields:    
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