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Semler, Bert L.

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMicrobiology and Molecular Genetics
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7573, 6058
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    Collapse Research 
    Collapse Research Activities and Funding
    Defining the nuclear vs. cytoplasmic proteome during human rhinovirus infections
    NIH/NIAID R21AI126879Jun 10, 2016 - May 31, 2018
    Role: Principal Investigator
    Role of host cell protein TDP2 as VPg unlinkase during picornavirus replication
    NIH/NIAID R01AI110782Feb 1, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Molecular Biology of Eukaryotic Viruses
    NIH/NIAID T32AI007319Sep 1, 1988 - Aug 31, 2019
    Role: Principal Investigator
    Impact of host protein dynamics on picornavirus RNA 5? noncoding region functions
    NIH/NIAID R01AI026765Jul 1, 1988 - Mar 31, 2020
    Role: Principal Investigator
    Functions of 5' NCRs of picornavirus and cellular mRNAs
    NIH/NIAID R56AI026765Jul 1, 1988 - Jun 30, 2009
    Role: Principal Investigator
    REPLICATION AND CAPSID ANTIGENS OF HEPATITIS A VIRUS
    NIH/NIAID R01AI026350Apr 1, 1988 - Nov 30, 1999
    Role: Principal Investigator
    POLIOVIRUS GENE FUNCTION AND REGULATION
    NIH/NIAID K04AI000721Sep 1, 1986 - Aug 31, 1991
    Role: Principal Investigator
    Poliovirus Gene Function and Regulation
    NIH/NIAID R01AI022693Jul 1, 1985 - Apr 30, 2016
    Role: Principal Investigator
    CONTROL OF TRANSLATION IN POLIOVIRUS CELLS
    NIH/NIAID R01AI012387May 1, 1975 - Feb 29, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ullmer W, Semler BL. Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells. MBio. 2018 Sep 04; 9(5). PMID: 30181254.
      View in: PubMed
    2. Flather D, Nguyen JHC, Semler BL, Gershon PD. Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus. PLoS Pathog. 2018 Aug 24; 14(8):e1007277. PMID: 30142213.
      View in: PubMed
    3. Maciejewski S, Ullmer W, Semler BL. VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage. Virology. 2018 03; 516:139-146. PMID: 29353210.
      View in: PubMed
    4. Lévêque N, Garcia M, Bouin A, Nguyen JHC, Tran GP, Andreoletti L, Semler BL. Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation. J Virol. 2017 08 15; 91(16). PMID: 28539455.
      View in: PubMed
    5. Karginov TA, Pastor DPH, Semler BL, Gomez CM. Mammalian Polycistronic mRNAs and Disease. Trends Genet. 2017 02; 33(2):129-142. PMID: 28012572.
      View in: PubMed
    6. Ullmer W, Semler BL. Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways. Viruses. 2016 12 20; 8(12). PMID: 27999393.
      View in: PubMed
    7. Flather D, Cathcart AL, Cruz C, Baggs E, Ngo T, Gershon PD, Semler BL. Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs. Viruses. 2016 Feb 04; 8(2). PMID: 26861382; PMCID: PMC4776194.
    8. Wehbe M, Huguenin A, Leveque N, Semler BL, Hamze M, Andreoletti L, Bouin A. Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells. J Virol Methods. 2016 Apr; 230:1-8. PMID: 26800776.
      View in: PubMed
    9. Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL. Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections. MBio. 2015 Dec 29; 7(1):e01931-15. PMID: 26715620; PMCID: PMC4725011.
    10. Hopcraft SE, Azarm KD, Israelow B, Lévêque N, Schwarz MC, Hsu TH, Chambers MT, Sourisseau M, Semler BL, Evans MJ. Viral Determinants of miR-122-Independent Hepatitis C Virus Replication. mSphere. 2016 Jan-Feb; 1(1). PMID: 27303683; PMCID: PMC4863629.
    11. Flather D, Semler BL. Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus. Front Microbiol. 2015; 6:594. PMID: 26150805; PMCID: PMC4471892.
    12. Lévêque N, Semler BL. A 21st century perspective of poliovirus replication. PLoS Pathog. 2015 Jun; 11(6):e1004825. PMID: 26042673; PMCID: PMC4456262.
    13. Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML. A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open Biol. 2014 Nov; 4(11):140180. PMID: 25392452; PMCID: PMC4248067.
    14. Cathcart AL, Semler BL. Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections. J Gen Virol. 2014 Jul; 95(Pt 7):1488-92. PMID: 24722678; PMCID: PMC4059269.
    15. Spindler KR, Semler BL. In memoriam John J. Holland (1929-2013): a pioneer in molecular virology. J Virol. 2014 Jun; 88(11):5903-5. PMID: 24623431; PMCID: PMC4093855.
    16. Du X, Semler BL, Gomez CM. Revelations from a bicistronic calcium channel gene. Cell Cycle. 2014; 13(6):875-6. PMID: 24552819; PMCID: PMC3984306.
    17. Chase AJ, Daijogo S, Semler BL. Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. J Virol. 2014 Mar; 88(6):3192-201. PMID: 24371074; PMCID: PMC3957957.
    18. Chase AJ, Semler BL. Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus. Virology. 2014 Jan 20; 449:35-44. PMID: 24418535; PMCID: PMC3894579.
    19. Langereis MA, Feng Q, Nelissen FH, Virgen-Slane R, van der Heden van Noort GJ, Maciejewski S, Filippov DV, Semler BL, van Delft FL, van Kuppeveld FJ. Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA. Nucleic Acids Res. 2014 Feb; 42(4):2473-82. PMID: 24243841; PMCID: PMC3936719.
    20. Cathcart AL, Rozovics JM, Semler BL. Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections. J Virol. 2013 Oct; 87(19):10423-34. PMID: 23903828; PMCID: PMC3807403.
    21. Fitzgerald KD, Semler BL. Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein. Virus Res. 2013 Sep; 176(1-2):223-31. PMID: 23830997; PMCID: PMC3742715.
    22. Semler BL, Whelan SP. Methods to study RNA virus molecular biology. Methods. 2013 Feb; 59(2):165-6. PMID: 23465704; PMCID: PMC4157455.
    23. Fitzgerald KD, Chase AJ, Cathcart AL, Tran GP, Semler BL. Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections. J Virol. 2013 Mar; 87(5):2390-400. PMID: 23255796; PMCID: PMC3571363.
    24. Feng Q, Hato SV, Langereis MA, Zoll J, Virgen-Slane R, Peisley A, Hur S, Semler BL, van Rij RP, van Kuppeveld FJ. MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells. Cell Rep. 2012 Nov 29; 2(5):1187-96. PMID: 23142662.
      View in: PubMed
    25. Rozovics JM, Chase AJ, Cathcart AL, Chou W, Gershon PD, Palusa S, Wilusz J, Semler BL. Picornavirus modification of a host mRNA decay protein. MBio. 2012 Nov 06; 3(6):e00431-12. PMID: 23131833; PMCID: PMC3487778.
    26. Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon PD, Semler BL. An RNA virus hijacks an incognito function of a DNA repair enzyme. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14634-9. PMID: 22908287; PMCID: PMC3437895.
    27. Chase AJ, Semler BL. Viral subversion of host functions for picornavirus translation and RNA replication. Future Virol. 2012 Feb; 7(2):179-191. PMID: 23293659.
      View in: PubMed
    28. Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S. SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage. PLoS Pathog. 2011 Dec; 7(12):e1002433. PMID: 22174690; PMCID: PMC3234236.
    29. Fitzgerald KD, Semler BL. Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus. PLoS Pathog. 2011 Jul; 7(7):e1002127. PMID: 21779168; PMCID: PMC3136463.
    30. Rozovics JM, Virgen-Slane R, Semler BL. Engineered picornavirus VPg-RNA substrates: analysis of a tyrosyl-RNA phosphodiesterase activity. PLoS One. 2011 Mar 07; 6(3):e16559. PMID: 21408223; PMCID: PMC3049768.
    31. Daijogo S, Semler BL. Mechanistic intersections between picornavirus translation and RNA replication. Adv Virus Res. 2011; 80:1-24. PMID: 21762819.
      View in: PubMed
    32. Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S. Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate. J Virol. 2011 Jan; 85(1):638-43. PMID: 21047955; PMCID: PMC3014157.
    33. Grainger L, Cicchini L, Rak M, Petrucelli A, Fitzgerald KD, Semler BL, Goodrum F. Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138. J Virol. 2010 Sep; 84(18):9472-86. PMID: 20592073; PMCID: PMC2937619.
    34. Brunner JE, Ertel KJ, Rozovics JM, Semler BL. Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. Virology. 2010 May 10; 400(2):240-7. PMID: 20189623; PMCID: PMC2844484.
    35. Ertel KJ, Brunner JE, Semler BL. Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates. J Virol. 2010 May; 84(9):4229-42. PMID: 20164237; PMCID: PMC2863767.
    36. Fitzgerald KD, Semler BL. Bridging IRES elements in mRNAs to the eukaryotic translation apparatus. Biochim Biophys Acta. 2009 Sep-Oct; 1789(9-10):518-28. PMID: 19631772; PMCID: PMC2783899.
    37. Sean P, Nguyen JH, Semler BL. Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity. Virology. 2009 Jun 20; 389(1-2):45-58. PMID: 19446305; PMCID: PMC2694229.
    38. Sean P, Nguyen JH, Semler BL. The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation. Virology. 2008 Sep 01; 378(2):243-53. PMID: 18656221; PMCID: PMC2595138.
    39. Semler BL, Waterman ML. IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes. Trends Microbiol. 2008 Jan; 16(1):1-5. PMID: 18083033.
      View in: PubMed
    40. Jang GM, Tanaka BS, Gutman GA, Goldin AL, Semler BL. Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression. Gene. 2008 Jan 31; 408(1-2):133-45. PMID: 18077107; PMCID: PMC2744407.
    41. Perera R, Daijogo S, Walter BL, Nguyen JH, Semler BL. Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein. J Virol. 2007 Sep; 81(17):8919-32. PMID: 17581994; PMCID: PMC1951425.
    42. Bedard KM, Daijogo S, Semler BL. A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation. EMBO J. 2007 Jan 24; 26(2):459-67. PMID: 17183366; PMCID: PMC1783453.
    43. Jimenez J, Jang GM, Semler BL, Waterman ML. An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. RNA. 2005 Sep; 11(9):1385-99. PMID: 16120831; PMCID: PMC1370822.
    44. Brown DM, Cornell CT, Tran GP, Nguyen JH, Semler BL. An authentic 3' noncoding region is necessary for efficient poliovirus replication. J Virol. 2005 Sep; 79(18):11962-73. PMID: 16140772; PMCID: PMC1212627.
    45. Semler BL. Resistance is futile. Nat Genet. 2005 Jul; 37(7):665-6. PMID: 15990885.
      View in: PubMed
    46. Boerner JE, Lyle JM, Daijogo S, Semler BL, Schultz SC, Kirkegaard K, Richards OC. Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase. J Virol. 2005 Jun; 79(12):7803-11. PMID: 15919933; PMCID: PMC1143668.
    47. Brunner JE, Nguyen JH, Roehl HH, Ho TV, Swiderek KM, Semler BL. Functional interaction of heterogeneous nuclear ribonucleoprotein C with poliovirus RNA synthesis initiation complexes. J Virol. 2005 Mar; 79(6):3254-66. PMID: 15731220; PMCID: PMC1075716.
    48. Kuznetsov YG, Daijogo S, Zhou J, Semler BL, McPherson A. Atomic force microscopy analysis of icosahedral virus RNA. J Mol Biol. 2005 Mar 18; 347(1):41-52. PMID: 15733916.
      View in: PubMed
    49. Cornell CT, Brunner JE, Semler BL. Differential rescue of poliovirus RNA replication functions by genetically modified RNA polymerase precursors. J Virol. 2004 Dec; 78(23):13007-18. PMID: 15542652; PMCID: PMC525034.
    50. Jang GM, Leong LE, Hoang LT, Wang PH, Gutman GA, Semler BL. Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA. J Biol Chem. 2004 Nov 12; 279(46):47419-30. PMID: 15339906.
      View in: PubMed
    51. Bedard KM, Walter BL, Semler BL. Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by a viral IRES. RNA. 2004 Aug; 10(8):1266-76. PMID: 15247434; PMCID: PMC1370616.
    52. Bedard KM, Semler BL. Regulation of picornavirus gene expression. Microbes Infect. 2004 Jun; 6(7):702-13. PMID: 15158778.
      View in: PubMed
    53. Semler BL. Poliovirus proves IRES-istible in vivo. J Clin Invest. 2004 Jun; 113(12):1678-81. PMID: 15199401; PMCID: PMC420512.
    54. Cornell CT, Perera R, Brunner JE, Semler BL. Strand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus. J Virol. 2004 May; 78(9):4397-407. PMID: 15078921; PMCID: PMC387695.
    55. Brown DM, Kauder SE, Cornell CT, Jang GM, Racaniello VR, Semler BL. Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis. J Virol. 2004 Feb; 78(3):1344-51. PMID: 14722289; PMCID: PMC321373.
    56. Towner JS, Brown DM, Nguyen JH, Semler BL. Functional conservation of the hydrophobic domain of polypeptide 3AB between human rhinovirus and poliovirus. Virology. 2003 Sep 15; 314(1):432-42. PMID: 14517095.
      View in: PubMed
    57. Walter BL, Parsley TB, Ehrenfeld E, Semler BL. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J Virol. 2002 Dec; 76(23):12008-22. PMID: 12414943; PMCID: PMC136902.
    58. Cornell CT, Semler BL. Subdomain specific functions of the RNA polymerase region of poliovirus 3CD polypeptide. Virology. 2002 Jul 05; 298(2):200-13. PMID: 12127783.
      View in: PubMed
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