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Semler, Bert L

Title(s)Professor, Microbiology and Molecular Genetics
Phone(949) 824-7573, 6058
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    Collapse Research 
    Collapse Research Activities and Funding
    Defining the nuclear vs. cytoplasmic proteome during human rhinovirus infections
    NIH/NIAID R21AI126879Jun 10, 2016 - May 31, 2018
    Role: Principal Investigator
    Role of host cell protein TDP2 as VPg unlinkase during picornavirus replication
    NIH/NIAID R01AI110782Feb 1, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Molecular Biology of Eukaryotic Viruses
    NIH/NIAID T32AI007319Sep 1, 1988 - Aug 31, 2019
    Role: Principal Investigator
    Impact of host protein dynamics on picornavirus RNA 5? noncoding region functions
    NIH/NIAID R01AI026765Jul 1, 1988 - Mar 31, 2020
    Role: Principal Investigator
    Functions of 5' NCRs of picornavirus and cellular mRNAs
    NIH/NIAID R56AI026765Jul 1, 1988 - Jun 30, 2009
    Role: Principal Investigator
    REPLICATION AND CAPSID ANTIGENS OF HEPATITIS A VIRUS
    NIH/NIAID R01AI026350Apr 1, 1988 - Nov 30, 1999
    Role: Principal Investigator
    POLIOVIRUS GENE FUNCTION AND REGULATION
    NIH/NIAID K04AI000721Sep 1, 1986 - Aug 31, 1991
    Role: Principal Investigator
    Poliovirus Gene Function and Regulation
    NIH/NIAID R01AI022693Jul 1, 1985 - Apr 30, 2016
    Role: Principal Investigator
    CONTROL OF TRANSLATION IN POLIOVIRUS CELLS
    NIH/NIAID R01AI012387May 1, 1975 - Feb 29, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bouin A, Gretteau PA, Wehbe M, Renois F, N'Guyen Y, Leveque N, Vu MN, Tracy S, Chapman NM, Bruneval P, Fornes P, Semler BL, Andreoletti L. Enterovirus Persistence in Cardiac Cells of Patients Suffering From Idiopathic Dilated Cardiomyopathy is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities. Circulation. 2019 Feb 13. PMID: 30755025.
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    2. Ullmer W, Semler BL. Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells. MBio. 2018 09 04; 9(5). PMID: 30181254.
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    3. Flather D, Nguyen JHC, Semler BL, Gershon PD. Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus. PLoS Pathog. 2018 08; 14(8):e1007277. PMID: 30142213.
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    4. Maciejewski S, Ullmer W, Semler BL. VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage. Virology. 2018 03; 516:139-146. PMID: 29353210.
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    5. Lévêque N, Garcia M, Bouin A, Nguyen JHC, Tran GP, Andreoletti L, Semler BL. Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation. J Virol. 2017 08 15; 91(16). PMID: 28539455.
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    6. Karginov TA, Pastor DPH, Semler BL, Gomez CM. Mammalian Polycistronic mRNAs and Disease. Trends Genet. 2017 02; 33(2):129-142. PMID: 28012572.
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    7. Ullmer W, Semler BL. Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways. Viruses. 2016 12 20; 8(12). PMID: 27999393.
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    8. Flather D, Cathcart AL, Cruz C, Baggs E, Ngo T, Gershon PD, Semler BL. Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs. Viruses. 2016 Feb 04; 8(2). PMID: 26861382.
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    9. Wehbe M, Huguenin A, Leveque N, Semler BL, Hamze M, Andreoletti L, Bouin A. Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells. J Virol Methods. 2016 Apr; 230:1-8. PMID: 26800776.
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    10. Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL. Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections. MBio. 2015 Dec 29; 7(1):e01931-15. PMID: 26715620.
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    11. Hopcraft SE, Azarm KD, Israelow B, Lévêque N, Schwarz MC, Hsu TH, Chambers MT, Sourisseau M, Semler BL, Evans MJ. Viral Determinants of miR-122-Independent Hepatitis C Virus Replication. mSphere. 2016 Jan-Feb; 1(1). PMID: 27303683.
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    12. Flather D, Semler BL. Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus. Front Microbiol. 2015; 6:594. PMID: 26150805.
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    13. Lévêque N, Semler BL. A 21st century perspective of poliovirus replication. PLoS Pathog. 2015 Jun; 11(6):e1004825. PMID: 26042673.
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    14. Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML. A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open Biol. 2014 Nov; 4(11):140180. PMID: 25392452.
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    15. Cathcart AL, Semler BL. Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections. J Gen Virol. 2014 Jul; 95(Pt 7):1488-92. PMID: 24722678.
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    16. Spindler KR, Semler BL. In memoriam John J. Holland (1929-2013): a pioneer in molecular virology. J Virol. 2014 Jun; 88(11):5903-5. PMID: 24623431.
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    17. Du X, Semler BL, Gomez CM. Revelations from a bicistronic calcium channel gene. Cell Cycle. 2014; 13(6):875-6. PMID: 24552819.
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    18. Chase AJ, Daijogo S, Semler BL. Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. J Virol. 2014 Mar; 88(6):3192-201. PMID: 24371074.
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    19. Chase AJ, Semler BL. Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus. Virology. 2014 Jan 20; 449:35-44. PMID: 24418535.
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    20. Langereis MA, Feng Q, Nelissen FH, Virgen-Slane R, van der Heden van Noort GJ, Maciejewski S, Filippov DV, Semler BL, van Delft FL, van Kuppeveld FJ. Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA. Nucleic Acids Res. 2014 Feb; 42(4):2473-82. PMID: 24243841.
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    21. Cathcart AL, Rozovics JM, Semler BL. Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections. J Virol. 2013 Oct; 87(19):10423-34. PMID: 23903828.
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    22. Fitzgerald KD, Semler BL. Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein. Virus Res. 2013 Sep; 176(1-2):223-31. PMID: 23830997.
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    23. Semler BL, Whelan SP. Methods to study RNA virus molecular biology. Methods. 2013 Feb; 59(2):165-6. PMID: 23465704.
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    24. Fitzgerald KD, Chase AJ, Cathcart AL, Tran GP, Semler BL. Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections. J Virol. 2013 Mar; 87(5):2390-400. PMID: 23255796.
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    25. Feng Q, Hato SV, Langereis MA, Zoll J, Virgen-Slane R, Peisley A, Hur S, Semler BL, van Rij RP, van Kuppeveld FJ. MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells. Cell Rep. 2012 Nov 29; 2(5):1187-96. PMID: 23142662.
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    26. Rozovics JM, Chase AJ, Cathcart AL, Chou W, Gershon PD, Palusa S, Wilusz J, Semler BL. Picornavirus modification of a host mRNA decay protein. MBio. 2012 Nov 06; 3(6):e00431-12. PMID: 23131833.
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    27. Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon PD, Semler BL. An RNA virus hijacks an incognito function of a DNA repair enzyme. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14634-9. PMID: 22908287.
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    28. Chase AJ, Semler BL. Viral subversion of host functions for picornavirus translation and RNA replication. Future Virol. 2012 Feb; 7(2):179-191. PMID: 23293659.
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    29. Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S. SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage. PLoS Pathog. 2011 Dec; 7(12):e1002433. PMID: 22174690.
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    30. Fitzgerald KD, Semler BL. Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus. PLoS Pathog. 2011 Jul; 7(7):e1002127. PMID: 21779168.
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    31. Rozovics JM, Virgen-Slane R, Semler BL. Engineered picornavirus VPg-RNA substrates: analysis of a tyrosyl-RNA phosphodiesterase activity. PLoS One. 2011 Mar 07; 6(3):e16559. PMID: 21408223.
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    32. Daijogo S, Semler BL. Mechanistic intersections between picornavirus translation and RNA replication. Adv Virus Res. 2011; 80:1-24. PMID: 21762819.
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    33. Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S. Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate. J Virol. 2011 Jan; 85(1):638-43. PMID: 21047955.
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    34. Grainger L, Cicchini L, Rak M, Petrucelli A, Fitzgerald KD, Semler BL, Goodrum F. Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138. J Virol. 2010 Sep; 84(18):9472-86. PMID: 20592073.
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    35. Brunner JE, Ertel KJ, Rozovics JM, Semler BL. Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. Virology. 2010 May 10; 400(2):240-7. PMID: 20189623.
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    36. Ertel KJ, Brunner JE, Semler BL. Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates. J Virol. 2010 May; 84(9):4229-42. PMID: 20164237.
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    37. Fitzgerald KD, Semler BL. Bridging IRES elements in mRNAs to the eukaryotic translation apparatus. Biochim Biophys Acta. 2009 Sep-Oct; 1789(9-10):518-28. PMID: 19631772.
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    38. Sean P, Nguyen JH, Semler BL. Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity. Virology. 2009 Jun 20; 389(1-2):45-58. PMID: 19446305.
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    39. Sean P, Nguyen JH, Semler BL. The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation. Virology. 2008 Sep 01; 378(2):243-53. PMID: 18656221.
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    40. Semler BL, Waterman ML. IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes. Trends Microbiol. 2008 Jan; 16(1):1-5. PMID: 18083033.
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    41. Sean P, Semler BL. Coxsackievirus B RNA replication: lessons from poliovirus. Curr Top Microbiol Immunol. 2008; 323:89-121. PMID: 18357767.
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    42. Jang GM, Tanaka BS, Gutman GA, Goldin AL, Semler BL. Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression. Gene. 2008 Jan 31; 408(1-2):133-45. PMID: 18077107.
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    43. Perera R, Daijogo S, Walter BL, Nguyen JH, Semler BL. Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein. J Virol. 2007 Sep; 81(17):8919-32. PMID: 17581994.
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    44. Bedard KM, Daijogo S, Semler BL. A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation. EMBO J. 2007 Jan 24; 26(2):459-67. PMID: 17183366.
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    45. Jimenez J, Jang GM, Semler BL, Waterman ML. An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. RNA. 2005 Sep; 11(9):1385-99. PMID: 16120831; PMCID: PMC1370822.
    46. Brown DM, Cornell CT, Tran GP, Nguyen JH, Semler BL. An authentic 3' noncoding region is necessary for efficient poliovirus replication. J Virol. 2005 Sep; 79(18):11962-73. PMID: 16140772; PMCID: PMC1212627.
    47. Semler BL. Resistance is futile. Nat Genet. 2005 Jul; 37(7):665-6. PMID: 15990885.
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    48. Boerner JE, Lyle JM, Daijogo S, Semler BL, Schultz SC, Kirkegaard K, Richards OC. Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase. J Virol. 2005 Jun; 79(12):7803-11. PMID: 15919933; PMCID: PMC1143668.
    49. Brunner JE, Nguyen JH, Roehl HH, Ho TV, Swiderek KM, Semler BL. Functional interaction of heterogeneous nuclear ribonucleoprotein C with poliovirus RNA synthesis initiation complexes. J Virol. 2005 Mar; 79(6):3254-66. PMID: 15731220; PMCID: PMC1075716.
    50. Kuznetsov YG, Daijogo S, Zhou J, Semler BL, McPherson A. Atomic force microscopy analysis of icosahedral virus RNA. J Mol Biol. 2005 Mar 18; 347(1):41-52. PMID: 15733916.
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    51. Cornell CT, Brunner JE, Semler BL. Differential rescue of poliovirus RNA replication functions by genetically modified RNA polymerase precursors. J Virol. 2004 Dec; 78(23):13007-18. PMID: 15542652; PMCID: PMC525034.
    52. Jang GM, Leong LE, Hoang LT, Wang PH, Gutman GA, Semler BL. Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA. J Biol Chem. 2004 Nov 12; 279(46):47419-30. PMID: 15339906.
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    53. Bedard KM, Walter BL, Semler BL. Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by a viral IRES. RNA. 2004 Aug; 10(8):1266-76. PMID: 15247434; PMCID: PMC1370616.
    54. Bedard KM, Semler BL. Regulation of picornavirus gene expression. Microbes Infect. 2004 Jun; 6(7):702-13. PMID: 15158778.
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    55. Semler BL. Poliovirus proves IRES-istible in vivo. J Clin Invest. 2004 Jun; 113(12):1678-81. PMID: 15199401; PMCID: PMC420512.
    56. Cornell CT, Perera R, Brunner JE, Semler BL. Strand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus. J Virol. 2004 May; 78(9):4397-407. PMID: 15078921; PMCID: PMC387695.
    57. Brown DM, Kauder SE, Cornell CT, Jang GM, Racaniello VR, Semler BL. Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis. J Virol. 2004 Feb; 78(3):1344-51. PMID: 14722289; PMCID: PMC321373.
    58. Towner JS, Brown DM, Nguyen JH, Semler BL. Functional conservation of the hydrophobic domain of polypeptide 3AB between human rhinovirus and poliovirus. Virology. 2003 Sep 15; 314(1):432-42. PMID: 14517095.
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    59. Walter BL, Parsley TB, Ehrenfeld E, Semler BL. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J Virol. 2002 Dec; 76(23):12008-22. PMID: 12414943; PMCID: PMC136902.
    60. Cornell CT, Semler BL. Subdomain specific functions of the RNA polymerase region of poliovirus 3CD polypeptide. Virology. 2002 Jul 05; 298(2):200-13. PMID: 12127783.
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    61. Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. New ways of initiating translation in eukaryotes. Mol Cell Biol. 2001 Dec; 21(23):8238-46. PMID: 11710333.
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    62. Walter H, Hertling I, Benda N, König B, Ramskogler K, Riegler A, Semler B, Zoghlami A, Lesch OM. Sensitivity and specificity of carbohydrate-deficient transferrin in drinking experiments and different patients. Alcohol. 2001 Nov; 25(3):189-94. PMID: 11839465.
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    63. Ramskogler K, Hertling I, Riegler A, Semler B, Zoghlami A, Walter H, Lesch OM. [Possible interaction between ethanol and drugs and their significance for drug therapy in the elderly]. Wien Klin Wochenschr. 2001 May 15; 113(10):363-70. PMID: 11432125.
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    64. Zitterl W, Urban C, Linzmayer L, Aigner M, Demal U, Semler B, Zitterl-Eglseer K. Memory deficits in patients with DSM-IV obsessive-compulsive disorder. Psychopathology. 2001 May-Jun; 34(3):113-7. PMID: 11316955.
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    65. Saletu M, Anderer P, Saletu-Zyhlarz G, Prause W, Semler B, Zoghlami A, Gruber G, Hauer C, Saletu B. Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam. Eur Neuropsychopharmacol. 2001 Apr; 11(2):153-61. PMID: 11313161.
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    66. Teterina NL, Egger D, Bienz K, Brown DM, Semler BL, Ehrenfeld E. Requirements for assembly of poliovirus replication complexes and negative-strand RNA synthesis. J Virol. 2001 Apr; 75(8):3841-50. PMID: 11264373.
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    67. Saletu M, Anderer P, Saletu B, Hauer C, Mandl M, Semler B, Saletu-Zyhlarz G. Sleep laboratory studies in periodic limb movement disorder (PLMD) patients as compared with normals and acute effects of ropinirole. Hum Psychopharmacol. 2001 Mar; 16(2):177-187. PMID: 12404588.
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    68. Semler B, Benda N, Ramskogler K, Haubenstock E. [Society-research-diagnosis: have classification problems in psychiatry been overcome at the beginning of the new millennium?]. Wien Med Wochenschr. 2001; 151(7-8):177-9. PMID: 11450168.
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    69. Saletu-Zyhlarz GM, Abu-Bakr MH, Anderer P, Semler B, Decker K, Parapatics S, Tschida U, Winkler A, Saletu B. Insomnia related to dysthymia: polysomnographic and psychometric comparison with normal controls and acute therapeutic trials with trazodone. Neuropsychobiology. 2001; 44(3):139-49. PMID: 11586054.
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    70. Ramskogler K, Semler B, Gutierrez K, Walter H. [Management of hallucinating patients]. Wien Med Wochenschr. 2001; 151(7-8):173-5. PMID: 11450167.
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    71. Semler B, Benda N, Ramskogler K, Walter H. [Diagnosis and differential diagnosis of consciousness disorders from the psychiatric viewpoint]. Wien Med Wochenschr. 2001; 151(11-12):270-3. PMID: 11515225.
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    72. Walter H, Ramskogler K, Semler B, Lesch OM, Platz W. Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials. J Biomed Sci. 2001 Jan-Feb; 8(1):83-8. PMID: 11173980.
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    73. Lesch OM, Riegler A, Gutierrez K, Hertling I, Ramskogler K, Semler B, Zoghlami A, Benda N, Walter H. The European acamprosate trials: conclusions for research and therapy. J Biomed Sci. 2001 Jan-Feb; 8(1):89-95. PMID: 11173981.
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    74. Chapman NM, Ragland A, Leser JS, Höfling K, Willian S, Semler BL, Tracy S. A group B coxsackievirus/poliovirus 5' nontranslated region chimera can act as an attenuated vaccine strain in mice. J Virol. 2000 May; 74(9):4047-56. PMID: 10756016.
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    75. Walter BL, Nguyen JH, Ehrenfeld E, Semler BL. Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements. RNA. 1999 Dec; 5(12):1570-85. PMID: 10606268.
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    76. Stewart SR, Semler BL. Pyrimidine-rich region mutations compensate for a stem-loop V lesion in the 5' noncoding region of poliovirus genomic RNA. Virology. 1999 Nov 25; 264(2):385-97. PMID: 10562500.
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    77. Bell YC, Semler BL, Ehrenfeld E. Requirements for RNA replication of a poliovirus replicon by coxsackievirus B3 RNA polymerase. J Virol. 1999 Nov; 73(11):9413-21. PMID: 10516050.
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    78. Parsley TB, Cornell CT, Semler BL. Modulation of the RNA binding and protein processing activities of poliovirus polypeptide 3CD by the viral RNA polymerase domain. J Biol Chem. 1999 Apr 30; 274(18):12867-76. PMID: 10212275.
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    79. Stewart SR, Semler BL. RNA structure adjacent to the attenuation determinant in the 5'-non-coding region influences poliovirus viability. Nucleic Acids Res. 1998 Dec 01; 26(23):5318-26. PMID: 9826754.
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    80. Towner JS, Mazanet MM, Semler BL. Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins. J Virol. 1998 Sep; 72(9):7191-200. PMID: 9696813.
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    81. Negulescu D, Leong LE, Chandy KG, Semler BL, Gutman GA. Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. J Biol Chem. 1998 Aug 07; 273(32):20109-13. PMID: 9685353.
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    82. Blair WS, Parsley TB, Bogerd HP, Towner JS, Semler BL, Cullen BR. Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases. RNA. 1998 Feb; 4(2):215-25. PMID: 9570321.
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    83. Todd S, Towner JS, Brown DM, Semler BL. Replication-competent picornaviruses with complete genomic RNA 3' noncoding region deletions. J Virol. 1997 Nov; 71(11):8868-74. PMID: 9343250.
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    84. Parsley TB, Towner JS, Blyn LB, Ehrenfeld E, Semler BL. Poly (rC) binding protein 2 forms a ternary complex with the 5'-terminal sequences of poliovirus RNA and the viral 3CD proteinase. RNA. 1997 Oct; 3(10):1124-34. PMID: 9326487.
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    85. Blyn LB, Towner JS, Semler BL, Ehrenfeld E. Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA. J Virol. 1997 Aug; 71(8):6243-6. PMID: 9223526.
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    86. Todd S, Towner JS, Semler BL. Translation and replication properties of the human rhinovirus genome in vivo and in vitro. Virology. 1997 Mar 03; 229(1):90-7. PMID: 9123881.
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    87. Roehl HH, Parsley TB, Ho TV, Semler BL. Processing of a cellular polypeptide by 3CD proteinase is required for poliovirus ribonucleoprotein complex formation. J Virol. 1997 Jan; 71(1):578-85. PMID: 8985386.
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    88. Towner JS, Ho TV, Semler BL. Determinants of membrane association for poliovirus protein 3AB. J Biol Chem. 1996 Oct 25; 271(43):26810-8. PMID: 8900162.
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    89. Blyn LB, Swiderek KM, Richards O, Stahl DC, Semler BL, Ehrenfeld E. Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):11115-20. PMID: 8855318.
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    90. Todd S, Semler BL. Structure-infectivity analysis of the human rhinovirus genomic RNA 3' non-coding region. Nucleic Acids Res. 1996 Jun 01; 24(11):2133-42. PMID: 8668546.
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    91. Lesch OM, Walter H, Freitag H, Heggli DE, Leitner A, Mader R, Neumeister A, Passweg V, Pusch H, Semler B, Sundrehagen E, Kasper S. Carbohydrate-deficient transferrin as a screening marker for drinking in a general hospital population. Alcohol Alcohol. 1996 May; 31(3):249-56. PMID: 8844030.
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    92. Lesch OM, Walter H, Antal J, Kanitz RD, Kovacz A, Leitner A, Marx B, Neumeister A, Saletu M, Semler B, Stumpf I, Mader R. Alcohol dependence: is carbohydrate-deficient transferrin a marker for alcohol intake? Alcohol Alcohol. 1996 May; 31(3):257-64. PMID: 8844031.
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    93. Blair WS, Nguyen JH, Parsley TB, Semler BL. Mutations in the poliovirus 3CD proteinase S1-specificity pocket affect substrate recognition and RNA binding. Virology. 1996 Apr 01; 218(1):1-13. PMID: 8615011.
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    94. Haller AA, Stewart SR, Semler BL. Attenuation stem-loop lesions in the 5' noncoding region of poliovirus RNA: neuronal cell-specific translation defects. J Virol. 1996 Mar; 70(3):1467-74. PMID: 8627664.
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    95. Blyn LB, Chen R, Semler BL, Ehrenfeld E. Host cell proteins binding to domain IV of the 5' noncoding region of poliovirus RNA. J Virol. 1995 Jul; 69(7):4381-9. PMID: 7769700.
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    96. Todd S, Nguyen JH, Semler BL. RNA-protein interactions directed by the 3' end of human rhinovirus genomic RNA. J Virol. 1995 Jun; 69(6):3605-14. PMID: 7745708.
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    97. Roehl HH, Semler BL. Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA. J Virol. 1995 May; 69(5):2954-61. PMID: 7707521.
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    98. Haller AA, Semler BL. Stem-loop structure synergy in binding cellular proteins to the 5' noncoding region of poliovirus RNA. Virology. 1995 Feb 01; 206(2):923-34. PMID: 7856105.
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    99. Ehrenfeld E, Semler BL. Anatomy of the poliovirus internal ribosome entry site. Curr Top Microbiol Immunol. 1995; 203:65-83. PMID: 7555091.
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    100. Charini WA, Todd S, Gutman GA, Semler BL. Transduction of a human RNA sequence by poliovirus. J Virol. 1994 Oct; 68(10):6547-52. PMID: 8083991.
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    101. Jungmann E, Krüger K, Semler B, Haak T, Scherberich J, Schumm-Draeger PM, Usadel KH. [The nephroprotective effect of ramipril. Effect on blood pressure and metabolic control in insulin-treated patients with type-2 diabetes mellitus]. Fortschr Med. 1994 Jan 30; 112(3):39-42. PMID: 8144124.
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    102. Dougherty WG, Semler BL. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes. Microbiol Rev. 1993 Dec; 57(4):781-822. PMID: 8302216.
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    103. Haller AA, Nguyen JH, Semler BL. Minimum internal ribosome entry site required for poliovirus infectivity. J Virol. 1993 Dec; 67(12):7461-71. PMID: 8230467.
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    104. Blair WS, Li X, Semler BL. A cellular cofactor facilitates efficient 3CD cleavage of the poliovirus P1 precursor. J Virol. 1993 Apr; 67(4):2336-43. PMID: 8383245.
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    105. Lawson MA, Semler BL. Alternate poliovirus nonstructural protein processing cascades generated by primary sites of 3C proteinase cleavage. Virology. 1992 Nov; 191(1):309-20. PMID: 1329322.
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    106. Giachetti C, Hwang SS, Semler BL. cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replication. J Virol. 1992 Oct; 66(10):6045-57. PMID: 1326655.
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    107. Haller AA, Semler BL. Linker scanning mutagenesis of the internal ribosome entry site of poliovirus RNA. J Virol. 1992 Aug; 66(8):5075-86. PMID: 1321289.
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    108. Dildine SL, Semler BL. Conservation of RNA-protein interactions among picornaviruses. J Virol. 1992 Jul; 66(7):4364-76. PMID: 1602550.
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    109. de la Torre JC, Giachetti C, Semler BL, Holland JJ. High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2531-5. PMID: 1313561.
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    110. Blair WS, Semler BL. Self-cleaving proteases. Curr Opin Cell Biol. 1991 Dec; 3(6):1039-45. PMID: 1814362.
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    111. Lawson MA, Semler BL. Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):9919-23. PMID: 1658804.
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    112. Blair WS, Semler BL. Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase. J Virol. 1991 Nov; 65(11):6111-23. PMID: 1656088.
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    113. Dildine SL, Stark KR, Haller AA, Semler BL. Poliovirus translation initiation: differential effects of directed and selected mutations in the 5' noncoding region of viral RNAs. Virology. 1991 Jun; 182(2):742-52. PMID: 1850926.
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    114. Charini WA, Burns CC, Ehrenfeld E, Semler BL. trans rescue of a mutant poliovirus RNA polymerase function. J Virol. 1991 May; 65(5):2655-65. PMID: 1850039.
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    115. Giachetti C, Semler BL. Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis. J Virol. 1991 May; 65(5):2647-54. PMID: 1850038.
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    116. Lawson MA, Dasmahapatra B, Semler BL. Species-specific substrate interaction of picornavirus 3C proteinase suballelic exchange mutants. J Biol Chem. 1990 Sep 15; 265(26):15920-31. PMID: 2168426.
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    117. Fu JL, Stein S, Rosenstein L, Bodwell T, Routbort M, Semler BL, Roos RP. Neurovirulence determinants of genetically engineered Theiler viruses. Proc Natl Acad Sci U S A. 1990 Jun; 87(11):4125-9. PMID: 2161533.
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    118. Blair WS, Hwang SS, Ypma-Wong MF, Semler BL. A mutant poliovirus containing a novel proteolytic cleavage site in VP3 is altered in viral maturation. J Virol. 1990 Apr; 64(4):1784-93. PMID: 2157059.
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    119. Dewalt PG, Blair WS, Semler BL. A genetic locus in mutant poliovirus genomes involved in overproduction of RNA polymerase and 3C proteinase. Virology. 1990 Feb; 174(2):504-14. PMID: 2154885.
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    120. Lawson MA, Semler BL. Picornavirus protein processing--enzymes, substrates, and genetic regulation. Curr Top Microbiol Immunol. 1990; 161:49-87. PMID: 2169385.
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    121. Roos RP, Kong WP, Semler BL. Polyprotein processing of Theiler's murine encephalomyelitis virus. J Virol. 1989 Dec; 63(12):5344-53. PMID: 2555559.
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    122. Roos RP, Stein S, Ohara Y, Fu JL, Semler BL. Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus. J Virol. 1989 Dec; 63(12):5492-6. PMID: 2555569.
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    123. Burns CC, Lawson MA, Semler BL, Ehrenfeld E. Effects of mutations in poliovirus 3Dpol on RNA polymerase activity and on polyprotein cleavage. J Virol. 1989 Nov; 63(11):4866-74. PMID: 2552159.
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    124. Dewalt PG, Lawson MA, Colonno RJ, Semler BL. Chimeric picornavirus polyproteins demonstrate a common 3C proteinase substrate specificity. J Virol. 1989 Aug; 63(8):3444-52. PMID: 2545915.
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    125. Dildine SL, Semler BL. The deletion of 41 proximal nucleotides reverts a poliovirus mutant containing a temperature-sensitive lesion in the 5' noncoding region of genomic RNA. J Virol. 1989 Feb; 63(2):847-62. PMID: 2536107.
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    126. Ypma-Wong MF, Filman DJ, Hogle JM, Semler BL. Structural domains of the poliovirus polyprotein are major determinants for proteolytic cleavage at Gln-Gly pairs. J Biol Chem. 1988 Nov 25; 263(33):17846-56. PMID: 2846581.
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    127. Kuhn RJ, Tada H, Ypma-Wong MF, Semler BL, Wimmer E. Mutational analysis of the genome-linked protein VPg of poliovirus. J Virol. 1988 Nov; 62(11):4207-15. PMID: 2845132.
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    128. Ypma-Wong MF, Dewalt PG, Johnson VH, Lamb JG, Semler BL. Protein 3CD is the major poliovirus proteinase responsible for cleavage of the P1 capsid precursor. Virology. 1988 Sep; 166(1):265-70. PMID: 2842953.
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    129. Kuhn RJ, Tada H, Ypma-Wong MF, Dunn JJ, Semler BL, Wimmer E. Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):519-23. PMID: 2829191.
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    130. Johnson VH, Semler BL. Defined recombinants of poliovirus and coxsackievirus: sequence-specific deletions and functional substitutions in the 5'-noncoding regions of viral RNAs. Virology. 1988 Jan; 162(1):47-57. PMID: 2827387.
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    131. Ypma-Wong MF, Semler BL. Processing determinants required for in vitro cleavage of the poliovirus P1 precursor to capsid proteins. J Virol. 1987 Oct; 61(10):3181-9. PMID: 3041039.
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    132. Dewalt PG, Semler BL. Site-directed mutagenesis of proteinase 3C results in a poliovirus deficient in synthesis of viral RNA polymerase. J Virol. 1987 Jul; 61(7):2162-70. PMID: 3035216.
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    133. Müller HP, Schmeer N, Rantamäki L, Semler B, Krauss H. Isolation of a protein antigen from Coxiella burnetii. Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jul; 265(3-4):277-89. PMID: 3118597.
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    134. Kuhn RJ, Wimmer E, Semler BL. Expression of the poliovirus genome from infectious cDNA is dependent upon arrangements of eukaryotic and prokaryotic sequences in recombinant plasmids. Virology. 1987 Apr; 157(2):560-4. PMID: 3029989.
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    135. Ypma-Wong MF, Semler BL. In vitro molecular genetics as a tool for determining the differential cleavage specificities of the poliovirus 3C proteinase. Nucleic Acids Res. 1987 Mar 11; 15(5):2069-88. PMID: 3031587.
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    136. Semler BL, Johnson VH, Dewalt PG, Ypma-Wong MF. Site-specific mutagenesis of cDNA clones expressing a poliovirus proteinase. J Cell Biochem. 1987 Jan; 33(1):39-51. PMID: 3029150.
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    137. Zschöck M, Semler B, Weiss R. [Comparative studies of the direct demonstration of K 99 antigen in calf fecal samples with special reference to the latex agglutination technic]. Zentralbl Veterinarmed B. 1986 Dec; 33(10):762-70. PMID: 3551408.
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    138. Kohara M, Abe S, Kuge S, Semler BL, Komatsu T, Arita M, Itoh H, Nomoto A. An infectious cDNA clone of the poliovirus Sabin strain could be used as a stable repository and inoculum for the oral polio live vaccine. Virology. 1986 May; 151(1):21-30. PMID: 3008430.
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    139. Omata T, Kohara M, Kuge S, Komatsu T, Abe S, Semler BL, Kameda A, Itoh H, Arita M, Wimmer E. Genetic analysis of the attenuation phenotype of poliovirus type 1. J Virol. 1986 May; 58(2):348-58. PMID: 3009852.
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    140. Semler BL, Johnson VH, Tracy S. A chimeric plasmid from cDNA clones of poliovirus and coxsackievirus produces a recombinant virus that is temperature-sensitive. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1777-81. PMID: 3006071.
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    141. Rotbart HA, Levin MJ, Villarreal LP, Tracy SM, Semler BL, Wimmer E. Factors affecting the detection of enteroviruses in cerebrospinal fluid with coxsackievirus B3 and poliovirus 1 cDNA probes. J Clin Microbiol. 1985 Aug; 22(2):220-4. PMID: 2993351.
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    142. Kohara M, Omata T, Kameda A, Semler BL, Itoh H, Wimmer E, Nomoto A. In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Mahoney strain and the attenuated Sabin 1 strain. J Virol. 1985 Mar; 53(3):786-92. PMID: 2983090.
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    143. Hanecak R, Semler BL, Ariga H, Anderson CW, Wimmer E. Expression of a cloned gene segment of poliovirus in E. coli: evidence for autocatalytic production of the viral proteinase. Cell. 1984 Jul; 37(3):1063-73. PMID: 6331675.
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    144. Semler BL, Dorner AJ, Wimmer E. Production of infectious poliovirus from cloned cDNA is dramatically increased by SV40 transcription and replication signals. Nucleic Acids Res. 1984 Jun 25; 12(12):5123-41. PMID: 6330698.
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    145. Dorner AJ, Semler BL, Jackson RJ, Hanecak R, Duprey E, Wimmer E. In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate. J Virol. 1984 May; 50(2):507-14. PMID: 6323749.
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    146. Pallansch MA, Kew OM, Semler BL, Omilianowski DR, Anderson CW, Wimmer E, Rueckert RR. Protein processing map of poliovirus. J Virol. 1984 Mar; 49(3):873-80. PMID: 6321771.
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    147. Takegami T, Semler BL, Anderson CW, Wimmer E. Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides. Virology. 1983 Jul 15; 128(1):33-47. PMID: 6308897.
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    148. Semler BL, Hanecak R, Dorner LF, Anderson CW, Wimmer E. Poliovirus RNA synthesis in vitro: structural elements and antibody inhibition. Virology. 1983 Apr 30; 126(2):624-35. PMID: 6305005.
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    149. Hanecak R, Semler BL, Anderson CW, Wimmer E. Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):3973-7. PMID: 6287457.
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    150. Semler BL, Anderson CW, Hanecak R, Dorner LF, Wimmer E. A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide. Cell. 1982 Feb; 28(2):405-12. PMID: 6277514.
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    151. Larsen GR, Anderson CW, Dorner AJ, Semler BL, Wimmer E. Cleavage sites within the poliovirus capsid protein precursors. J Virol. 1982 Jan; 41(1):340-4. PMID: 6283126.
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    152. Semler BL, Hanecak R, Anderson CW, Wimmer E. Cleavage sites in the polypeptide precursors of poliovirus protein P2-X. Virology. 1981 Oct 30; 114(2):589-94. PMID: 6270891.
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    153. Kitamura N, Semler BL, Rothberg PG, Larsen GR, Adler CJ, Dorner AJ, Emini EA, Hanecak R, Lee JJ, van der Werf S, Anderson CW, Wimmer E. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature. 1981 Jun 18; 291(5816):547-53. PMID: 6264310.
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    154. Semler BL, Anderson CW, Kitamura N, Rothberg PG, Wishart WL, Wimmer E. Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3464-8. PMID: 6267593.
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    155. Larsen GR, Semler BL, Wimmer E. Stable hairpin structure within the 5'-terminal 85 nucleotides of poliovirus RNA. J Virol. 1981 Jan; 37(1):328-35. PMID: 6260985.
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    156. Golini F, Semler BL, Dorner AJ, Wimmer E. Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro. Nature. 1980 Oct 16; 287(5783):600-3. PMID: 6253803.
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    157. Rowlands K, Grabau E, Spindler K, Jones C, Semler B, Holland J. Virus protein changes and RNA termini alterations evolving during persistent infection. Cell. 1980 Apr; 19(4):871-80. PMID: 6247073.
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    158. Perrault J, Semler BL. Internal genome deletions in two distinct classes of defective interfering particles of vesicular stomatitis virus. Proc Natl Acad Sci U S A. 1979 Dec; 76(12):6191-5. PMID: 230501.
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    159. Semler BL, Holland JJ. Persistent vesicular stomatitis virus infection mediates base substitutions in viral RNA termini. J Virol. 1979 Nov; 32(2):420-8. PMID: 228067.
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    160. Semler BL, Perrault J, Holland JJ. The nucleotide sequence of the 5' terminus of vesicular stomatitis virus RNA. Nucleic Acids Res. 1979 Aug 24; 6(12):3923-31. PMID: 226942.
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    161. Holland JJ, Grabau EA, Jones CL, Semler BL. Evolution of multiple genome mutations during long-term persistent infection by vesicular stomatitis virus. Cell. 1979 Mar; 16(3):495-504. PMID: 222463.
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    162. Semler BL, Perrault J, Abelson J, Holland JJ. Sequence of a RNA templated by the 3'-OH RNA terminus of defective interfering particles of vesicular stomatitis virus. Proc Natl Acad Sci U S A. 1978 Oct; 75(10):4704-8. PMID: 216996.
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    163. Semler BL, Hodson RC, Williams SK II, Howell SH. The induction of allophanate lyase during the vegetative cell cycle in light-synchronized cultures of Chlamydomonas reinhardi. Biochim Biophys Acta. 1975 Jul 14; 399(1):71-8. PMID: 1148280.
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