Bert L Semler

Title(s)Professor, Microbiology and Molecular Genetics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-7573, 6058
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    Collapse Research 
    Collapse Research Activities and Funding
    Nuclear functions co-opted by human rhinovirus during replication in the cytoplasm of infected cells
    NIH R01AI155962Jul 2, 2021 - Aug 31, 2026
    Role: Principal Investigator
    Synthesis of enterovirus positive-strand RNAs: discovery of viral and host determinants of RNP complex formation
    NIH R21AI145003Jan 30, 2020 - Dec 31, 2021
    Role: Principal Investigator
    Genetically engineered anterograde monosynaptic viral tracers for multi-species neural circuit analysis
    NIH RF1MH120020Aug 15, 2019 - Jul 31, 2022
    Role: Co-Principal Investigator
    Defining the nuclear vs. cytoplasmic proteome during human rhinovirus infections
    NIH R21AI126879Jun 10, 2016 - May 31, 2019
    Role: Principal Investigator
    Role of host cell protein TDP2 as VPg unlinkase during picornavirus replication
    NIH R01AI110782Feb 1, 2014 - Jan 31, 2020
    Role: Principal Investigator
    Virus-host interactions: a multi-scale training program
    NIH T32AI007319Sep 1, 1988 - Aug 31, 2025
    Role: Principal Investigator
    Impact of host protein dynamics on picornavirus RNA 5? noncoding region functions
    NIH R01AI026765Jul 1, 1988 - Mar 31, 2021
    Role: Principal Investigator
    Functions of 5' NCRs of picornavirus and cellular mRNAs
    NIH R56AI026765Jul 1, 1988 - Jun 30, 2009
    Role: Principal Investigator
    REPLICATION AND CAPSID ANTIGENS OF HEPATITIS A VIRUS
    NIH R01AI026350Apr 1, 1988 - Nov 30, 1999
    Role: Principal Investigator
    POLIOVIRUS GENE FUNCTION AND REGULATION
    NIH K04AI000721Sep 1, 1986 - Aug 31, 1991
    Role: Principal Investigator
    Poliovirus Gene Function and Regulation
    NIH R01AI022693Jul 1, 1985 - Apr 30, 2017
    Role: Principal Investigator
    CONTROL OF TRANSLATION IN POLIOVIRUS CELLS
    NIH R01AI012387May 1, 1975 - Feb 29, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. New rabies viral resources for multi-scale neural circuit mapping. Mol Psychiatry. 2024 Feb 14. Bouin A, Wu G, Koyuncu OO, Ye Q, Kim KY, Wu MY, Tong L, Chen L, Phan S, Mackey MR, Ramachandra R, Ellisman MH, Holmes TC, Semler BL, Xu X. PMID: 38355784.
      View in: PubMed   Mentions:    Fields:    
    2. APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection. Nat Commun. 2023 02 14; 14(1):820. Manjunath L, Oh S, Ortega P, Bouin A, Bournique E, Sanchez A, Martensen PM, Auerbach AA, Becker JT, Seldin M, Harris RS, Semler BL, Buisson R. PMID: 36781883; PMCID: PMC9925369.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    3. Virology under the Microscope-a Call for Rational Discourse. mSphere. 2023 04 20; 8(2):e0003423. Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. PMID: 36700653; PMCID: PMC10117089.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    4. Virology under the Microscope-a Call for Rational Discourse. J Virol. 2023 02 28; 97(2):e0008923. Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. PMID: 36700640; PMCID: PMC9972907.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCellsPHPublic Health
    5. Virology under the Microscope-a Call for Rational Discourse. mBio. 2023 02 28; 14(1):e0018823. Goodrum F, Lowen AC, Lakdawala S, Alwine J, Casadevall A, Imperiale MJ, Atwood W, Avgousti D, Baines J, Banfield B, Banks L, Bhaduri-McIntosh S, Bhattacharya D, Blanco-Melo D, Bloom D, Boon A, Boulant S, Brandt C, Broadbent A, Brooke C, Cameron C, Campos S, Caposio P, Chan G, Cliffe A, Coffin J, Collins K, Damania B, Daugherty M, Debbink K, DeCaprio J, Dermody T, Dikeakos J, DiMaio D, Dinglasan R, Duprex WP, Dutch R, Elde N, Emerman M, Enquist L, Fane B, Fernandez-Sesma A, Flenniken M, Frappier L, Frieman M, Frueh K, Gack M, Gaglia M, Gallagher T, Galloway D, García-Sastre A, Geballe A, Glaunsinger B, Goff S, Greninger A, Hancock M, Harris E, Heaton N, Heise M, Heldwein E, Hogue B, Horner S, Hutchinson E, Hyser J, Jackson W, Kalejta R, Kamil J, Karst S, Kirchhoff F, Knipe D, Kowalik T, Lagunoff M, Laimins L, Langlois R, Lauring A, Lee B, Leib D, Liu SL, Longnecker R, Lopez C, Luftig M, Lund J, Manicassamy B, McFadden G, McIntosh M, Mehle A, Miller WA, Mohr I, Moody C, Moorman N, Moscona A, Mounce B, Munger J, Münger K, Murphy E, Naghavi M, Nelson J, Neufeldt C, Nikolich J, O'Connor C, Ono A, Orenstein W, Ornelles D, Ou JH, Parker J, Parrish C, Pekosz A, Pellett P, Pfeiffer J, Plemper R, Polyak S, Purdy J, Pyeon D, Quinones-Mateu M, Renne R, Rice C, Schoggins J, Roller R, Russell C, Sandri-Goldin R, Sapp M, Schang L, Schmid S, Schultz-Cherry S, Semler B, Shenk T, Silvestri G, Simon V, Smith G, Smith J, Spindler K, Stanifer M, Subbarao K, Sundquist W, Suthar M, Sutton T, Tai A, Tarakanova V, tenOever B, Tibbetts S, Tompkins S, Toth Z, van Doorslaer K, Vignuzzi M, Wallace N, Walsh D, Weekes M, Weinberg J, Weitzman M, Weller S, Whelan S, White E, Williams B, Wobus C, Wong S, Yurochko A. PMID: 36700642; PMCID: PMC9973315.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    6. Enterovirus-Cardiomyocyte Interactions: Impact of Terminally Deleted Genomic RNAs on Viral and Host Functions. J Virol. 2023 01 31; 97(1):e0142622. Bouin A, Vu MN, Al-Hakeem A, Tran GP, Nguyen JHC, Semler BL. PMID: 36475766; PMCID: PMC9888282.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Single-tube collection and nucleic acid analysis of clinical samples for SARS-CoV-2 saliva testing. Sci Rep. 2022 03 10; 12(1):3951. Cole KH, Bouin A, Ruiz C, Semler BL, Inlay MA, Lupták A. PMID: 35273232; PMCID: PMC8913774.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Genotoxic stress and viral infection induce transient expression of APOBEC3A and pro-inflammatory genes through two distinct pathways. Nat Commun. 2021 08 13; 12(1):4917. Oh S, Bournique E, Bowen D, Jalili P, Sanchez A, Ward I, Dananberg A, Manjunath L, Tran GP, Semler BL, Maciejowski J, Seldin M, Buisson R. PMID: 34389714; PMCID: PMC8363607.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    9. Structure of the PCBP2/stem-loop IV complex underlying translation initiation mediated by the poliovirus type I IRES. Nucleic Acids Res. 2020 08 20; 48(14):8006-8021. Beckham SA, Matak MY, Belousoff MJ, Venugopal H, Shah N, Vankadari N, Elmlund H, Nguyen JHC, Semler BL, Wilce MCJ, Wilce JA. PMID: 32556302; PMCID: PMC7641305.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    10. Viral Vectors for Neural Circuit Mapping and Recent Advances in Trans-synaptic Anterograde Tracers. Neuron. 2020 09 23; 107(6):1029-1047. Xu X, Holmes TC, Luo MH, Beier KT, Horwitz GD, Zhao F, Zeng W, Hui M, Semler BL, Sandri-Goldin RM. PMID: 32755550; PMCID: PMC7530073.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    11. Picornavirus Cellular Remodeling: Doubling Down in Response to Viral-Induced Inflammation. Curr Clin Microbiol Rep. 2020 Jun; 7(2):31-37. Bouin A, Semler BL. PMID: 32704466; PMCID: PMC7377643.
      View in: PubMed   Mentions: 4  
    12. Effects of TDP2/VPg Unlinkase Activity on Picornavirus Infections Downstream of Virus Translation. Viruses. 2020 01 31; 12(2). Holmes AC, Zagnoli-Vieira G, Caldecott KW, Semler BL. PMID: 32023921; PMCID: PMC7077319.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. Picornaviruses and RNA Metabolism: Local and Global Effects of Infection. J Virol. 2019 11 01; 93(21). Holmes AC, Semler BL. PMID: 31413128; PMCID: PMC6803262.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    14. Enterovirus Persistence in Cardiac Cells of Patients With Idiopathic Dilated Cardiomyopathy Is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities. Circulation. 2019 05 14; 139(20):2326-2338. Bouin A, Gretteau PA, Wehbe M, Renois F, N'Guyen Y, Lévêque N, Vu MN, Tracy S, Chapman NM, Bruneval P, Fornes P, Semler BL, Andreoletti L. PMID: 30755025; PMCID: PMC6517084.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    15. Direct and Indirect Effects on Viral Translation and RNA Replication Are Required for AUF1 Restriction of Enterovirus Infections in Human Cells. mBio. 2018 09 04; 9(5). Ullmer W, Semler BL. PMID: 30181254; PMCID: PMC6123441.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus. PLoS Pathog. 2018 08; 14(8):e1007277. Flather D, Nguyen JHC, Semler BL, Gershon PD. PMID: 30142213; PMCID: PMC6126879.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage. Virology. 2018 03; 516:139-146. Maciejewski S, Ullmer W, Semler BL. PMID: 29353210; PMCID: PMC5826889.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    18. Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation. J Virol. 2017 08 15; 91(16). Lévêque N, Garcia M, Bouin A, Nguyen JHC, Tran GP, Andreoletti L, Semler BL. PMID: 28539455; PMCID: PMC5533909.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    19. Mammalian Polycistronic mRNAs and Disease. Trends Genet. 2017 02; 33(2):129-142. Karginov TA, Pastor DPH, Semler BL, Gomez CM. PMID: 28012572; PMCID: PMC5285393.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    20. Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways. Viruses. 2016 12 20; 8(12). Ullmer W, Semler BL. PMID: 27999393; PMCID: PMC5192396.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    21. Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs. Viruses. 2016 Feb 04; 8(2). Flather D, Cathcart AL, Cruz C, Baggs E, Ngo T, Gershon PD, Semler BL. PMID: 26861382; PMCID: PMC4776194.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells. J Virol Methods. 2016 Apr; 230:1-8. Wehbe M, Huguenin A, Leveque N, Semler BL, Hamze M, Andreoletti L, Bouin A. PMID: 26800776; PMCID: PMC7433696.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections. mBio. 2015 Dec 29; 7(1):e01931-15. Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL. PMID: 26715620; PMCID: PMC4725011.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. Viral Determinants of miR-122-Independent Hepatitis C Virus Replication. mSphere. 2016 Jan-Feb; 1(1). Hopcraft SE, Azarm KD, Israelow B, Lévêque N, Schwarz MC, Hsu TH, Chambers MT, Sourisseau M, Semler BL, Evans MJ. PMID: 27303683; PMCID: PMC4863629.
      View in: PubMed   Mentions: 21     Fields:    
    25. Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus. Front Microbiol. 2015; 6:594. Flather D, Semler BL. PMID: 26150805; PMCID: PMC4471892.
      View in: PubMed   Mentions: 44  
    26. A 21st century perspective of poliovirus replication. PLoS Pathog. 2015 Jun; 11(6):e1004825. Lévêque N, Semler BL. PMID: 26042673; PMCID: PMC4456262.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    27. A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. Open Biol. 2014 Nov; 4(11):140180. Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML. PMID: 25392452; PMCID: PMC4248067.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections. J Gen Virol. 2014 Jul; 95(Pt 7):1488-1492. Cathcart AL, Semler BL. PMID: 24722678; PMCID: PMC4059269.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    29. In memoriam John J. Holland (1929-2013): a pioneer in molecular virology. J Virol. 2014 Jun; 88(11):5903-5. Spindler KR, Semler BL. PMID: 24623431; PMCID: PMC4093855.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    30. Revelations from a bicistronic calcium channel gene. Cell Cycle. 2014; 13(6):875-6. Du X, Semler BL, Gomez CM. PMID: 24552819; PMCID: PMC3984306.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    31. Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication. J Virol. 2014 Mar; 88(6):3192-201. Chase AJ, Daijogo S, Semler BL. PMID: 24371074; PMCID: PMC3957957.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    32. Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus. Virology. 2014 Jan 20; 449:35-44. Chase AJ, Semler BL. PMID: 24418535; PMCID: PMC3894579.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    33. Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA. Nucleic Acids Res. 2014 Feb; 42(4):2473-82. Langereis MA, Feng Q, Nelissen FH, Virgen-Slane R, van der Heden van Noort GJ, Maciejewski S, Filippov DV, Semler BL, van Delft FL, van Kuppeveld FJ. PMID: 24243841; PMCID: PMC3936719.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    34. Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections. J Virol. 2013 Oct; 87(19):10423-34. Cathcart AL, Rozovics JM, Semler BL. PMID: 23903828; PMCID: PMC3807403.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    35. Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein. Virus Res. 2013 Sep; 176(1-2):223-31. Fitzgerald KD, Semler BL. PMID: 23830997; PMCID: PMC3742715.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    36. Methods to study RNA virus molecular biology. Methods. 2013 Feb; 59(2):165-6. Semler BL, Whelan SP. PMID: 23465704; PMCID: PMC4157455.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    37. Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections. J Virol. 2013 Mar; 87(5):2390-400. Fitzgerald KD, Chase AJ, Cathcart AL, Tran GP, Semler BL. PMID: 23255796; PMCID: PMC3571363.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    38. MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells. Cell Rep. 2012 Nov 29; 2(5):1187-96. Feng Q, Hato SV, Langereis MA, Zoll J, Virgen-Slane R, Peisley A, Hur S, Semler BL, van Rij RP, van Kuppeveld FJ. PMID: 23142662; PMCID: PMC7103987.
      View in: PubMed   Mentions: 139     Fields:    Translation:HumansAnimalsCells
    39. Picornavirus modification of a host mRNA decay protein. mBio. 2012 Nov 06; 3(6):e00431-12. Rozovics JM, Chase AJ, Cathcart AL, Chou W, Gershon PD, Palusa S, Wilusz J, Semler BL. PMID: 23131833; PMCID: PMC3487778.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    40. An RNA virus hijacks an incognito function of a DNA repair enzyme. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14634-9. Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon PD, Semler BL. PMID: 22908287; PMCID: PMC3437895.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    41. Viral subversion of host functions for picornavirus translation and RNA replication. Future Virol. 2012 Feb; 7(2):179-191. Chase AJ, Semler BL. PMID: 23293659; PMCID: PMC3535308.
      View in: PubMed   Mentions: 31  
    42. SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage. PLoS Pathog. 2011 Dec; 7(12):e1002433. Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S. PMID: 22174690; PMCID: PMC3234236.
      View in: PubMed   Mentions: 211     Fields:    Translation:Cells
    43. Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus. PLoS Pathog. 2011 Jul; 7(7):e1002127. Fitzgerald KD, Semler BL. PMID: 21779168; PMCID: PMC3136463.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    44. Engineered picornavirus VPg-RNA substrates: analysis of a tyrosyl-RNA phosphodiesterase activity. PLoS One. 2011 Mar 07; 6(3):e16559. Rozovics JM, Virgen-Slane R, Semler BL. PMID: 21408223; PMCID: PMC3049768.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    45. Mechanistic intersections between picornavirus translation and RNA replication. Adv Virus Res. 2011; 80:1-24. Daijogo S, Semler BL. PMID: 21762819.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    46. Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate. J Virol. 2011 Jan; 85(1):638-43. Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S. PMID: 21047955; PMCID: PMC3014157.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    47. Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138. J Virol. 2010 Sep; 84(18):9472-86. Grainger L, Cicchini L, Rak M, Petrucelli A, Fitzgerald KD, Semler BL, Goodrum F. PMID: 20592073; PMCID: PMC2937619.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    48. Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins. Virology. 2010 May 10; 400(2):240-7. Brunner JE, Ertel KJ, Rozovics JM, Semler BL. PMID: 20189623; PMCID: PMC2844484.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    49. Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates. J Virol. 2010 May; 84(9):4229-42. Ertel KJ, Brunner JE, Semler BL. PMID: 20164237; PMCID: PMC2863767.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    50. Bridging IRES elements in mRNAs to the eukaryotic translation apparatus. Biochim Biophys Acta. 2009 Sep-Oct; 1789(9-10):518-28. Fitzgerald KD, Semler BL. PMID: 19631772; PMCID: PMC2783899.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    51. Altered interactions between stem-loop IV within the 5' noncoding region of coxsackievirus RNA and poly(rC) binding protein 2: effects on IRES-mediated translation and viral infectivity. Virology. 2009 Jun 20; 389(1-2):45-58. Sean P, Nguyen JH, Semler BL. PMID: 19446305; PMCID: PMC2694229.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    52. The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation. Virology. 2008 Sep 01; 378(2):243-53. Sean P, Nguyen JH, Semler BL. PMID: 18656221; PMCID: PMC2595138.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    53. IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes. Trends Microbiol. 2008 Jan; 16(1):1-5. Semler BL, Waterman ML. PMID: 18083033.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    54. Coxsackievirus B RNA replication: lessons from poliovirus. Curr Top Microbiol Immunol. 2008; 323:89-121. Sean P, Semler BL. PMID: 18357767.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    55. Alternative polyadenylation signals in the 3' non-coding region of a voltage-gated potassium channel gene are major determinants of mRNA isoform expression. Gene. 2008 Jan 31; 408(1-2):133-45. Jang GM, Tanaka BS, Gutman GA, Goldin AL, Semler BL. PMID: 18077107; PMCID: PMC2744407.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    56. Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein. J Virol. 2007 Sep; 81(17):8919-32. Perera R, Daijogo S, Walter BL, Nguyen JH, Semler BL. PMID: 17581994; PMCID: PMC1951425.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    57. A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation. EMBO J. 2007 Jan 24; 26(2):459-67. Bedard KM, Daijogo S, Semler BL. PMID: 17183366; PMCID: PMC1783453.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    58. An authentic 3' noncoding region is necessary for efficient poliovirus replication. J Virol. 2005 Sep; 79(18):11962-73. Brown DM, Cornell CT, Tran GP, Nguyen JH, Semler BL. PMID: 16140772; PMCID: PMC1212627.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    59. An internal ribosome entry site mediates translation of lymphoid enhancer factor-1. RNA. 2005 Sep; 11(9):1385-99. Jimenez J, Jang GM, Semler BL, Waterman ML. PMID: 16120831; PMCID: PMC1370822.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    60. Resistance is futile. Nat Genet. 2005 Jul; 37(7):665-6. Semler BL. PMID: 15990885; PMCID: PMC7097394.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    61. Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase. J Virol. 2005 Jun; 79(12):7803-11. Boerner JE, Lyle JM, Daijogo S, Semler BL, Schultz SC, Kirkegaard K, Richards OC. PMID: 15919933; PMCID: PMC1143668.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    62. Functional interaction of heterogeneous nuclear ribonucleoprotein C with poliovirus RNA synthesis initiation complexes. J Virol. 2005 Mar; 79(6):3254-66. Brunner JE, Nguyen JH, Roehl HH, Ho TV, Swiderek KM, Semler BL. PMID: 15731220; PMCID: PMC1075716.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    63. Atomic force microscopy analysis of icosahedral virus RNA. J Mol Biol. 2005 Mar 18; 347(1):41-52. Kuznetsov YG, Daijogo S, Zhou J, Semler BL, McPherson A. PMID: 15733916.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    64. Differential rescue of poliovirus RNA replication functions by genetically modified RNA polymerase precursors. J Virol. 2004 Dec; 78(23):13007-18. Cornell CT, Brunner JE, Semler BL. PMID: 15542652; PMCID: PMC525034.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    65. Structurally distinct elements mediate internal ribosome entry within the 5'-noncoding region of a voltage-gated potassium channel mRNA. J Biol Chem. 2004 Nov 12; 279(46):47419-30. Jang GM, Leong LE, Hoang LT, Wang PH, Gutman GA, Semler BL. PMID: 15339906.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    66. Multimerization of poly(rC) binding protein 2 is required for translation initiation mediated by a viral IRES. RNA. 2004 Aug; 10(8):1266-76. Bedard KM, Walter BL, Semler BL. PMID: 15247434; PMCID: PMC1370616.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    67. Regulation of picornavirus gene expression. Microbes Infect. 2004 Jun; 6(7):702-13. Bedard KM, Semler BL. PMID: 15158778.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansCells
    68. Poliovirus proves IRES-istible in vivo. J Clin Invest. 2004 Jun; 113(12):1678-81. Semler BL. PMID: 15199401; PMCID: PMC420512.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    69. Strand-specific RNA synthesis determinants in the RNA-dependent RNA polymerase of poliovirus. J Virol. 2004 May; 78(9):4397-407. Cornell CT, Perera R, Brunner JE, Semler BL. PMID: 15078921; PMCID: PMC387695.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    70. Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis. J Virol. 2004 Feb; 78(3):1344-51. Brown DM, Kauder SE, Cornell CT, Jang GM, Racaniello VR, Semler BL. PMID: 14722289; PMCID: PMC321373.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    71. Functional conservation of the hydrophobic domain of polypeptide 3AB between human rhinovirus and poliovirus. Virology. 2003 Sep 15; 314(1):432-42. Towner JS, Brown DM, Nguyen JH, Semler BL. PMID: 14517095.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    72. Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication. J Virol. 2002 Dec; 76(23):12008-22. Walter BL, Parsley TB, Ehrenfeld E, Semler BL. PMID: 12414943; PMCID: PMC136902.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    73. Subdomain specific functions of the RNA polymerase region of poliovirus 3CD polypeptide. Virology. 2002 Jul 05; 298(2):200-13. Cornell CT, Semler BL. PMID: 12127783.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    74. New ways of initiating translation in eukaryotes. Mol Cell Biol. 2001 Dec; 21(23):8238-46. Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M. PMID: 11710333; PMCID: PMC99989.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    75. [Possible interaction between ethanol and drugs and their significance for drug therapy in the elderly]. Wien Klin Wochenschr. 2001 May 15; 113(10):363-70. Ramskogler K, Hertling I, Riegler A, Semler B, Zoghlami A, Walter H, Lesch OM. PMID: 11432125.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    76. Memory deficits in patients with DSM-IV obsessive-compulsive disorder. Psychopathology. 2001 May-Jun; 34(3):113-7. Zitterl W, Urban C, Linzmayer L, Aigner M, Demal U, Semler B, Zitterl-Eglseer K. PMID: 11316955.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    77. Requirements for assembly of poliovirus replication complexes and negative-strand RNA synthesis. J Virol. 2001 Apr; 75(8):3841-50. Teterina NL, Egger D, Bienz K, Brown DM, Semler BL, Ehrenfeld E. PMID: 11264373; PMCID: PMC114875.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    78. Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam. Eur Neuropsychopharmacol. 2001 Apr; 11(2):153-61. Saletu M, Anderer P, Saletu-Zyhlarz G, Prause W, Semler B, Zoghlami A, Gruber G, Hauer C, Saletu B. PMID: 11313161.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCTClinical Trials
    79. Dopamine and alcohol relapse: D1 and D2 antagonists increase relapse rates in animal studies and in clinical trials. J Biomed Sci. 2001 Jan-Feb; 8(1):83-8. Walter H, Ramskogler K, Semler B, Lesch OM, Platz W. PMID: 11173980.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    80. The European acamprosate trials: conclusions for research and therapy. J Biomed Sci. 2001 Jan-Feb; 8(1):89-95. Lesch OM, Riegler A, Gutierrez K, Hertling I, Ramskogler K, Semler B, Zoghlami A, Benda N, Walter H. PMID: 11173981.
      View in: PubMed   Mentions: 7     Fields:    Translation:PHPublic Health
    81. [Society-research-diagnosis: have classification problems in psychiatry been overcome at the beginning of the new millennium?]. Wien Med Wochenschr. 2001; 151(7-8):177-9. Semler B, Benda N, Ramskogler K, Haubenstock E. PMID: 11450168.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    82. [Management of hallucinating patients]. Wien Med Wochenschr. 2001; 151(7-8):173-5. Ramskogler K, Semler B, Gutierrez K, Walter H. PMID: 11450167.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    83. A group B coxsackievirus/poliovirus 5' nontranslated region chimera can act as an attenuated vaccine strain in mice. J Virol. 2000 May; 74(9):4047-56. Chapman NM, Ragland A, Leser JS, Höfling K, Willian S, Semler BL, Tracy S. PMID: 10756016; PMCID: PMC111918.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    84. Differential utilization of poly(rC) binding protein 2 in translation directed by picornavirus IRES elements. RNA. 1999 Dec; 5(12):1570-85. Walter BL, Nguyen JH, Ehrenfeld E, Semler BL. PMID: 10606268; PMCID: PMC1369879.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    85. Pyrimidine-rich region mutations compensate for a stem-loop V lesion in the 5' noncoding region of poliovirus genomic RNA. Virology. 1999 Nov 25; 264(2):385-97. Stewart SR, Semler BL. PMID: 10562500.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    86. Requirements for RNA replication of a poliovirus replicon by coxsackievirus B3 RNA polymerase. J Virol. 1999 Nov; 73(11):9413-21. Bell YC, Semler BL, Ehrenfeld E. PMID: 10516050; PMCID: PMC112976.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    87. Modulation of the RNA binding and protein processing activities of poliovirus polypeptide 3CD by the viral RNA polymerase domain. J Biol Chem. 1999 Apr 30; 274(18):12867-76. Parsley TB, Cornell CT, Semler BL. PMID: 10212275.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    88. RNA structure adjacent to the attenuation determinant in the 5'-non-coding region influences poliovirus viability. Nucleic Acids Res. 1998 Dec 01; 26(23):5318-26. Stewart SR, Semler BL. PMID: 9826754; PMCID: PMC148017.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    89. Rescue of defective poliovirus RNA replication by 3AB-containing precursor polyproteins. J Virol. 1998 Sep; 72(9):7191-200. Towner JS, Mazanet MM, Semler BL. PMID: 9696813; PMCID: PMC109941.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    90. Translation initiation of a cardiac voltage-gated potassium channel by internal ribosome entry. J Biol Chem. 1998 Aug 07; 273(32):20109-13. Negulescu D, Leong LE, Chandy KG, Semler BL, Gutman GA. PMID: 9685353.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    91. Utilization of a mammalian cell-based RNA binding assay to characterize the RNA binding properties of picornavirus 3C proteinases. RNA. 1998 Feb; 4(2):215-25. Blair WS, Parsley TB, Bogerd HP, Towner JS, Semler BL, Cullen BR. PMID: 9570321; PMCID: PMC1369610.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    92. Replication-competent picornaviruses with complete genomic RNA 3' noncoding region deletions. J Virol. 1997 Nov; 71(11):8868-74. Todd S, Towner JS, Brown DM, Semler BL. PMID: 9343250; PMCID: PMC192356.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    93. Poly (rC) binding protein 2 forms a ternary complex with the 5'-terminal sequences of poliovirus RNA and the viral 3CD proteinase. RNA. 1997 Oct; 3(10):1124-34. Parsley TB, Towner JS, Blyn LB, Ehrenfeld E, Semler BL. PMID: 9326487; PMCID: PMC1369554.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCells
    94. Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA. J Virol. 1997 Aug; 71(8):6243-6. Blyn LB, Towner JS, Semler BL, Ehrenfeld E. PMID: 9223526; PMCID: PMC191892.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    95. Translation and replication properties of the human rhinovirus genome in vivo and in vitro. Virology. 1997 Mar 03; 229(1):90-7. Todd S, Towner JS, Semler BL. PMID: 9123881.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    96. Processing of a cellular polypeptide by 3CD proteinase is required for poliovirus ribonucleoprotein complex formation. J Virol. 1997 Jan; 71(1):578-85. Roehl HH, Parsley TB, Ho TV, Semler BL. PMID: 8985386; PMCID: PMC191087.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    97. Determinants of membrane association for poliovirus protein 3AB. J Biol Chem. 1996 Oct 25; 271(43):26810-8. Towner JS, Ho TV, Semler BL. PMID: 8900162.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    98. Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5' noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):11115-20. Blyn LB, Swiderek KM, Richards O, Stahl DC, Semler BL, Ehrenfeld E. PMID: 8855318; PMCID: PMC38293.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansCells
    99. Structure-infectivity analysis of the human rhinovirus genomic RNA 3' non-coding region. Nucleic Acids Res. 1996 Jun 01; 24(11):2133-42. Todd S, Semler BL. PMID: 8668546; PMCID: PMC145920.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    100. Alcohol dependence: is carbohydrate-deficient transferrin a marker for alcohol intake? Alcohol Alcohol. 1996 May; 31(3):257-64. Lesch OM, Walter H, Antal J, Kanitz RD, Kovacz A, Leitner A, Marx B, Neumeister A, Saletu M, Semler B, Stumpf I, Mader R. PMID: 8844031.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    101. Carbohydrate-deficient transferrin as a screening marker for drinking in a general hospital population. Alcohol Alcohol. 1996 May; 31(3):249-56. Lesch OM, Walter H, Freitag H, Heggli DE, Leitner A, Mader R, Neumeister A, Passweg V, Pusch H, Semler B, Sundrehagen E, Kasper S. PMID: 8844030.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    102. Mutations in the poliovirus 3CD proteinase S1-specificity pocket affect substrate recognition and RNA binding. Virology. 1996 Apr 01; 218(1):1-13. Blair WS, Nguyen JH, Parsley TB, Semler BL. PMID: 8615011.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    103. Attenuation stem-loop lesions in the 5' noncoding region of poliovirus RNA: neuronal cell-specific translation defects. J Virol. 1996 Mar; 70(3):1467-74. Haller AA, Stewart SR, Semler BL. PMID: 8627664; PMCID: PMC189967.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    104. Host cell proteins binding to domain IV of the 5' noncoding region of poliovirus RNA. J Virol. 1995 Jul; 69(7):4381-9. Blyn LB, Chen R, Semler BL, Ehrenfeld E. PMID: 7769700; PMCID: PMC189179.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    105. RNA-protein interactions directed by the 3' end of human rhinovirus genomic RNA. J Virol. 1995 Jun; 69(6):3605-14. Todd S, Nguyen JH, Semler BL. PMID: 7745708; PMCID: PMC189075.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    106. Poliovirus infection enhances the formation of two ribonucleoprotein complexes at the 3' end of viral negative-strand RNA. J Virol. 1995 May; 69(5):2954-61. Roehl HH, Semler BL. PMID: 7707521; PMCID: PMC188994.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    107. Stem-loop structure synergy in binding cellular proteins to the 5' noncoding region of poliovirus RNA. Virology. 1995 Feb 01; 206(2):923-34. Haller AA, Semler BL. PMID: 7856105.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    108. Anatomy of the poliovirus internal ribosome entry site. Curr Top Microbiol Immunol. 1995; 203:65-83. Ehrenfeld E, Semler BL. PMID: 7555091.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    109. Transduction of a human RNA sequence by poliovirus. J Virol. 1994 Oct; 68(10):6547-52. Charini WA, Todd S, Gutman GA, Semler BL. PMID: 8083991; PMCID: PMC237075.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    110. [The nephroprotective effect of ramipril. Effect on blood pressure and metabolic control in insulin-treated patients with type-2 diabetes mellitus]. Fortschr Med. 1994 Jan 30; 112(3):39-42. Jungmann E, Krüger K, Semler B, Haak T, Scherberich J, Schumm-Draeger PM, Usadel KH. PMID: 8144124.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    111. Minimum internal ribosome entry site required for poliovirus infectivity. J Virol. 1993 Dec; 67(12):7461-71. Haller AA, Nguyen JH, Semler BL. PMID: 8230467; PMCID: PMC238212.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    112. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes. Microbiol Rev. 1993 Dec; 57(4):781-822. Dougherty WG, Semler BL. PMID: 8302216; PMCID: PMC372939.
      View in: PubMed   Mentions: 142     Fields:    Translation:Cells
    113. A cellular cofactor facilitates efficient 3CD cleavage of the poliovirus P1 precursor. J Virol. 1993 Apr; 67(4):2336-43. Blair WS, Li X, Semler BL. PMID: 8383245; PMCID: PMC240391.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    114. Alternate poliovirus nonstructural protein processing cascades generated by primary sites of 3C proteinase cleavage. Virology. 1992 Nov; 191(1):309-20. Lawson MA, Semler BL. PMID: 1329322.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    115. cis-acting lesions targeted to the hydrophobic domain of a poliovirus membrane protein involved in RNA replication. J Virol. 1992 Oct; 66(10):6045-57. Giachetti C, Hwang SS, Semler BL. PMID: 1326655; PMCID: PMC241482.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    116. Linker scanning mutagenesis of the internal ribosome entry site of poliovirus RNA. J Virol. 1992 Aug; 66(8):5075-86. Haller AA, Semler BL. PMID: 1321289; PMCID: PMC241370.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    117. Conservation of RNA-protein interactions among picornaviruses. J Virol. 1992 Jul; 66(7):4364-76. Dildine SL, Semler BL. PMID: 1602550; PMCID: PMC241243.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    118. High frequency of single-base transitions and extreme frequency of precise multiple-base reversion mutations in poliovirus. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2531-5. de la Torre JC, Giachetti C, Semler BL, Holland JJ. PMID: 1313561; PMCID: PMC48695.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    119. Self-cleaving proteases. Curr Opin Cell Biol. 1991 Dec; 3(6):1039-45. Blair WS, Semler BL. PMID: 1814362.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    120. Poliovirus thiol proteinase 3C can utilize a serine nucleophile within the putative catalytic triad. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):9919-23. Lawson MA, Semler BL. PMID: 1658804; PMCID: PMC52838.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    121. Role for the P4 amino acid residue in substrate utilization by the poliovirus 3CD proteinase. J Virol. 1991 Nov; 65(11):6111-23. Blair WS, Semler BL. PMID: 1656088; PMCID: PMC250289.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    122. Poliovirus translation initiation: differential effects of directed and selected mutations in the 5' noncoding region of viral RNAs. Virology. 1991 Jun; 182(2):742-52. Dildine SL, Stark KR, Haller AA, Semler BL. PMID: 1850926.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    123. trans rescue of a mutant poliovirus RNA polymerase function. J Virol. 1991 May; 65(5):2655-65. Charini WA, Burns CC, Ehrenfeld E, Semler BL. PMID: 1850039; PMCID: PMC240624.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    124. Role of a viral membrane polypeptide in strand-specific initiation of poliovirus RNA synthesis. J Virol. 1991 May; 65(5):2647-54. Giachetti C, Semler BL. PMID: 1850038; PMCID: PMC240623.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    125. Species-specific substrate interaction of picornavirus 3C proteinase suballelic exchange mutants. J Biol Chem. 1990 Sep 15; 265(26):15920-31. Lawson MA, Dasmahapatra B, Semler BL. PMID: 2168426.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    126. Neurovirulence determinants of genetically engineered Theiler viruses. Proc Natl Acad Sci U S A. 1990 Jun; 87(11):4125-9. Fu JL, Stein S, Rosenstein L, Bodwell T, Routbort M, Semler BL, Roos RP. PMID: 2161533; PMCID: PMC54060.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    127. A mutant poliovirus containing a novel proteolytic cleavage site in VP3 is altered in viral maturation. J Virol. 1990 Apr; 64(4):1784-93. Blair WS, Hwang SS, Ypma-Wong MF, Semler BL. PMID: 2157059; PMCID: PMC249316.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    128. A genetic locus in mutant poliovirus genomes involved in overproduction of RNA polymerase and 3C proteinase. Virology. 1990 Feb; 174(2):504-14. Dewalt PG, Blair WS, Semler BL. PMID: 2154885.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    129. Picornavirus protein processing--enzymes, substrates, and genetic regulation. Curr Top Microbiol Immunol. 1990; 161:49-87. Lawson MA, Semler BL. PMID: 2169385.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    130. Polyprotein processing of Theiler's murine encephalomyelitis virus. J Virol. 1989 Dec; 63(12):5344-53. Roos RP, Kong WP, Semler BL. PMID: 2555559; PMCID: PMC251201.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    131. Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus. J Virol. 1989 Dec; 63(12):5492-6. Roos RP, Stein S, Ohara Y, Fu JL, Semler BL. PMID: 2555569; PMCID: PMC251223.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    132. Effects of mutations in poliovirus 3Dpol on RNA polymerase activity and on polyprotein cleavage. J Virol. 1989 Nov; 63(11):4866-74. Burns CC, Lawson MA, Semler BL, Ehrenfeld E. PMID: 2552159; PMCID: PMC251125.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    133. Chimeric picornavirus polyproteins demonstrate a common 3C proteinase substrate specificity. J Virol. 1989 Aug; 63(8):3444-52. Dewalt PG, Lawson MA, Colonno RJ, Semler BL. PMID: 2545915; PMCID: PMC250920.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    134. The deletion of 41 proximal nucleotides reverts a poliovirus mutant containing a temperature-sensitive lesion in the 5' noncoding region of genomic RNA. J Virol. 1989 Feb; 63(2):847-62. Dildine SL, Semler BL. PMID: 2536107; PMCID: PMC247759.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    135. Structural domains of the poliovirus polyprotein are major determinants for proteolytic cleavage at Gln-Gly pairs. J Biol Chem. 1988 Nov 25; 263(33):17846-56. Ypma-Wong MF, Filman DJ, Hogle JM, Semler BL. PMID: 2846581.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    136. Mutational analysis of the genome-linked protein VPg of poliovirus. J Virol. 1988 Nov; 62(11):4207-15. Kuhn RJ, Tada H, Ypma-Wong MF, Semler BL, Wimmer E. PMID: 2845132; PMCID: PMC253853.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    137. Protein 3CD is the major poliovirus proteinase responsible for cleavage of the P1 capsid precursor. Virology. 1988 Sep; 166(1):265-70. Ypma-Wong MF, Dewalt PG, Johnson VH, Lamb JG, Semler BL. PMID: 2842953.
      View in: PubMed   Mentions: 153     Fields:    Translation:Cells
    138. Construction of a "mutagenesis cartridge" for poliovirus genome-linked viral protein: isolation and characterization of viable and nonviable mutants. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):519-23. Kuhn RJ, Tada H, Ypma-Wong MF, Dunn JJ, Semler BL, Wimmer E. PMID: 2829191; PMCID: PMC279582.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    139. Defined recombinants of poliovirus and coxsackievirus: sequence-specific deletions and functional substitutions in the 5'-noncoding regions of viral RNAs. Virology. 1988 Jan; 162(1):47-57. Johnson VH, Semler BL. PMID: 2827387.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    140. Processing determinants required for in vitro cleavage of the poliovirus P1 precursor to capsid proteins. J Virol. 1987 Oct; 61(10):3181-9. Ypma-Wong MF, Semler BL. PMID: 3041039; PMCID: PMC255896.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    141. Site-directed mutagenesis of proteinase 3C results in a poliovirus deficient in synthesis of viral RNA polymerase. J Virol. 1987 Jul; 61(7):2162-70. Dewalt PG, Semler BL. PMID: 3035216; PMCID: PMC254238.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    142. Isolation of a protein antigen from Coxiella burnetii. Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Jul; 265(3-4):277-89. Müller HP, Schmeer N, Rantamäki L, Semler B, Krauss H. PMID: 3118597.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    143. Expression of the poliovirus genome from infectious cDNA is dependent upon arrangements of eukaryotic and prokaryotic sequences in recombinant plasmids. Virology. 1987 Apr; 157(2):560-4. Kuhn RJ, Wimmer E, Semler BL. PMID: 3029989.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    144. In vitro molecular genetics as a tool for determining the differential cleavage specificities of the poliovirus 3C proteinase. Nucleic Acids Res. 1987 Mar 11; 15(5):2069-88. Ypma-Wong MF, Semler BL. PMID: 3031587; PMCID: PMC340618.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    145. Site-specific mutagenesis of cDNA clones expressing a poliovirus proteinase. J Cell Biochem. 1987 Jan; 33(1):39-51. Semler BL, Johnson VH, Dewalt PG, Ypma-Wong MF. PMID: 3029150.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    146. [Comparative studies of the direct demonstration of K 99 antigen in calf fecal samples with special reference to the latex agglutination technic]. Zentralbl Veterinarmed B. 1986 Dec; 33(10):762-70. Zschöck M, Semler B, Weiss R. PMID: 3551408.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    147. Genetic analysis of the attenuation phenotype of poliovirus type 1. J Virol. 1986 May; 58(2):348-58. Omata T, Kohara M, Kuge S, Komatsu T, Abe S, Semler BL, Kameda A, Itoh H, Arita M, Wimmer E, et al. PMID: 3009852; PMCID: PMC252919.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    148. An infectious cDNA clone of the poliovirus Sabin strain could be used as a stable repository and inoculum for the oral polio live vaccine. Virology. 1986 May; 151(1):21-30. Kohara M, Abe S, Kuge S, Semler BL, Komatsu T, Arita M, Itoh H, Nomoto A. PMID: 3008430.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    149. A chimeric plasmid from cDNA clones of poliovirus and coxsackievirus produces a recombinant virus that is temperature-sensitive. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1777-81. Semler BL, Johnson VH, Tracy S. PMID: 3006071; PMCID: PMC323167.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    150. Factors affecting the detection of enteroviruses in cerebrospinal fluid with coxsackievirus B3 and poliovirus 1 cDNA probes. J Clin Microbiol. 1985 Aug; 22(2):220-4. Rotbart HA, Levin MJ, Villarreal LP, Tracy SM, Semler BL, Wimmer E. PMID: 2993351; PMCID: PMC268363.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    151. In vitro phenotypic markers of a poliovirus recombinant constructed from infectious cDNA clones of the neurovirulent Mahoney strain and the attenuated Sabin 1 strain. J Virol. 1985 Mar; 53(3):786-92. Kohara M, Omata T, Kameda A, Semler BL, Itoh H, Wimmer E, Nomoto A. PMID: 2983090; PMCID: PMC254708.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    152. Expression of a cloned gene segment of poliovirus in E. coli: evidence for autocatalytic production of the viral proteinase. Cell. 1984 Jul; 37(3):1063-73. Hanecak R, Semler BL, Ariga H, Anderson CW, Wimmer E. PMID: 6331675.
      View in: PubMed   Mentions: 35     Fields:    Translation:Cells
    153. Production of infectious poliovirus from cloned cDNA is dramatically increased by SV40 transcription and replication signals. Nucleic Acids Res. 1984 Jun 25; 12(12):5123-41. Semler BL, Dorner AJ, Wimmer E. PMID: 6330698; PMCID: PMC318905.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    154. In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate. J Virol. 1984 May; 50(2):507-14. Dorner AJ, Semler BL, Jackson RJ, Hanecak R, Duprey E, Wimmer E. PMID: 6323749; PMCID: PMC255658.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    155. Protein processing map of poliovirus. J Virol. 1984 Mar; 49(3):873-80. Pallansch MA, Kew OM, Semler BL, Omilianowski DR, Anderson CW, Wimmer E, Rueckert RR. PMID: 6321771; PMCID: PMC255549.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    156. Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides. Virology. 1983 Jul 15; 128(1):33-47. Takegami T, Semler BL, Anderson CW, Wimmer E. PMID: 6308897.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    157. Poliovirus RNA synthesis in vitro: structural elements and antibody inhibition. Virology. 1983 Apr 30; 126(2):624-35. Semler BL, Hanecak R, Dorner LF, Anderson CW, Wimmer E. PMID: 6305005.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    158. Proteolytic processing of poliovirus polypeptides: antibodies to polypeptide P3-7c inhibit cleavage at glutamine-glycine pairs. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):3973-7. Hanecak R, Semler BL, Anderson CW, Wimmer E. PMID: 6287457; PMCID: PMC346558.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansCells
    159. A membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide. Cell. 1982 Feb; 28(2):405-12. Semler BL, Anderson CW, Hanecak R, Dorner LF, Wimmer E. PMID: 6277514.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    160. Cleavage sites within the poliovirus capsid protein precursors. J Virol. 1982 Jan; 41(1):340-4. Larsen GR, Anderson CW, Dorner AJ, Semler BL, Wimmer E. PMID: 6283126; PMCID: PMC256758.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    161. Cleavage sites in the polypeptide precursors of poliovirus protein P2-X. Virology. 1981 Oct 30; 114(2):589-94. Semler BL, Hanecak R, Anderson CW, Wimmer E. PMID: 6270891.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    162. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature. 1981 Jun 18; 291(5816):547-53. Kitamura N, Semler BL, Rothberg PG, Larsen GR, Adler CJ, Dorner AJ, Emini EA, Hanecak R, Lee JJ, van der Werf S, Anderson CW, Wimmer E. PMID: 6264310.
      View in: PubMed   Mentions: 348     Fields:    Translation:Cells
    163. Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3464-8. Semler BL, Anderson CW, Kitamura N, Rothberg PG, Wishart WL, Wimmer E. PMID: 6267593; PMCID: PMC319589.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    164. Stable hairpin structure within the 5'-terminal 85 nucleotides of poliovirus RNA. J Virol. 1981 Jan; 37(1):328-35. Larsen GR, Semler BL, Wimmer E. PMID: 6260985; PMCID: PMC171010.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    165. Protein-linked RNA of poliovirus is competent to form an initiation complex of translation in vitro. Nature. 1980 Oct 16; 287(5783):600-3. Golini F, Semler BL, Dorner AJ, Wimmer E. PMID: 6253803.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    166. Virus protein changes and RNA termini alterations evolving during persistent infection. Cell. 1980 Apr; 19(4):871-80. Rowlands K, Grabau E, Spindler K, Jones C, Semler B, Holland J. PMID: 6247073.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    167. Internal genome deletions in two distinct classes of defective interfering particles of vesicular stomatitis virus. Proc Natl Acad Sci U S A. 1979 Dec; 76(12):6191-5. Perrault J, Semler BL. PMID: 230501; PMCID: PMC411829.
      View in: PubMed   Mentions: 30     Fields:    Translation:Cells
    168. Persistent vesicular stomatitis virus infection mediates base substitutions in viral RNA termini. J Virol. 1979 Nov; 32(2):420-8. Semler BL, Holland JJ. PMID: 228067; PMCID: PMC353573.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    169. The nucleotide sequence of the 5' terminus of vesicular stomatitis virus RNA. Nucleic Acids Res. 1979 Aug 24; 6(12):3923-31. Semler BL, Perrault J, Holland JJ. PMID: 226942; PMCID: PMC327987.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    170. Evolution of multiple genome mutations during long-term persistent infection by vesicular stomatitis virus. Cell. 1979 Mar; 16(3):495-504. Holland JJ, Grabau EA, Jones CL, Semler BL. PMID: 222463.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    171. Sequence of a RNA templated by the 3'-OH RNA terminus of defective interfering particles of vesicular stomatitis virus. Proc Natl Acad Sci U S A. 1978 Oct; 75(10):4704-8. Semler BL, Perrault J, Abelson J, Holland JJ. PMID: 216996; PMCID: PMC336188.
      View in: PubMed   Mentions: 27     Fields:    Translation:Cells
    172. The induction of allophanate lyase during the vegetative cell cycle in light-synchronized cultures of Chlamydomonas reinhardi. Biochim Biophys Acta. 1975 Jul 14; 399(1):71-8. Semler BL, Hodson RC, Williams SK II, Howell SH. PMID: 1148280.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
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