Christie D. Fowler

Title(s)Assistant Professor, Neurobiology & Behavior
SchoolSchool of Biological Sciences
Address1232 McGaugh Hall
Zot 4550
Irvine CA 92697
Phone(949) 824-8363
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    Collapse Research 
    Collapse Research Activities and Funding
    SRNT 2021 Annual Meeting
    NIH R13FD007301Jan 15, 2021 - Dec 31, 2021
    Role: Co-Principal Investigator
    Impact of THC on Extracellular Vesicle Signaling
    NIH R01DA051831Jun 15, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Circulating miRNAs and Epigenetic Regulation in Nicotine Addiction
    NIH DP1DA039658Jul 1, 2015 - Jun 30, 2021
    Role: Principal Investigator
    The Habenulo-Interpeduncular Pathway and Nicotine
    NIH R00DA032543Aug 1, 2014 - Jul 31, 2017
    Role: Principal Investigator
    The Habenulo-Interpeduncular Pathway and Nicotine
    NIH K99DA032543Jun 1, 2012 - May 31, 2014
    Role: Principal Investigator
    The alpha5 Nicotinic Acetylcholine Receptor Subunit in Nicotine Dependence
    NIH F32DA026693Apr 1, 2009 - Mar 31, 2012
    Role: Principal Investigator
    Social Experience and Adult Neurogenesis
    NIH F31MH064352Aug 5, 2001
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Preclinical assessment of MAGMAS inhibitor as a potential therapy for pediatric medulloblastoma. bioRxiv. 2024 Mar 03. Motahari Z, Lepe JJ, Bautista MR, Hoerig C, Plant-Fox AS, Das B, Fowler CD, Magge SN, Bota DA. PMID: 38464047; PMCID: PMC10925277.
      View in: PubMed   Mentions:
    2. Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats. Neurobiol Stress. 2024 May; 30:100620. Lallai V, Congiu C, Craig G, Manca L, Chen YC, Dukes AJ, Fowler CD, Dazzi L. PMID: 38486879; PMCID: PMC10937317.
      View in: PubMed   Mentions:
    3. Cannabidiol as a potential cessation therapeutic: Effects on intravenous nicotine self-administration and withdrawal symptoms in mice. Neuropharmacology. 2024 Mar 15; 246:109833. Cheeks SN, Buzzi B, Valdez A, Mogul AS, Damaj MI, Fowler CD. PMID: 38176534; PMCID: PMC10958588.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Extracellular ATP Neurotransmission and Nicotine Sex-Specifically Modulate Habenular Neuronal Activity in Adolescence. J Neurosci. 2023 11 29; 43(48):8259-8270. Chen YC, Rindner DJ, Fowler JP, Lallai V, Mogul A, Demuro A, Lur G, Fowler CD. PMID: 37821229; PMCID: PMC10697394.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Beyond the label: current evidence and future directions for the interrelationship between electronic cigarettes and mental health. Front Psychiatry. 2023; 14:1134079. Bautista M, Mogul AS, Fowler CD. PMID: 37645635; PMCID: PMC10460914.
      View in: PubMed   Mentions:
    6. Exomap1 mouse: a transgenic model for in vivo studies of exosome biology. bioRxiv. 2023 May 29. Fordjour FK, Abuelreich S, Hong X, Chatterjee E, Lallai V, Ng M, Saftics A, Deng F, Carnel-Amar N, Wakimoto H, Shimizu K, Bautista M, Phu TA, Vu NK, Geiger PC, Raffai RL, Fowler CD, Das S, Christenson LK, Jovanovic-Talisman T, Gould SJ. PMID: 37398219; PMCID: PMC10312766.
      View in: PubMed   Mentions:
    7. Nasal accumulation and metabolism of Δ9-tetrahydrocannabinol following aerosol ('vaping') administration in an adolescent rat model. Pharmacol Res. 2023 01; 187:106600. Torrens A, Ruiz CM, Martinez MX, Tagne AM, Roy P, Grimes D, Ahmed F, Lallai V, Inshishian V, Bautista M, Chen YC, Huestis MA, Das A, Fowler CD, Mahler SV, Piomelli D. PMID: 36481259; PMCID: PMC9845136.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    8. Effects of Prenatal Nicotine, THC, or Co-Exposure on Cognitive Behaviors in Adolescent Male and Female Rats. Nicotine Tob Res. 2022 07 13; 24(8):1150-1160. Lallai V, Manca L, Sherafat Y, Fowler CD. PMID: 35090174; PMCID: PMC9278841.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    9. Tobacco and nicotine use. Nat Rev Dis Primers. 2022 03 24; 8(1):19. Le Foll B, Piper ME, Fowler CD, Tonstad S, Bierut L, Lu L, Jha P, Hall WD. PMID: 35332148.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    10. Disruption of VGLUT1 in Cholinergic Medial Habenula Projections Increases Nicotine Self-Administration. eNeuro. 2022 Jan-Feb; 9(1). Souter EA, Chen YC, Zell V, Lallai V, Steinkellner T, Conrad WS, Wisden W, Harris KD, Fowler CD, Hnasko TS. PMID: 34876472; PMCID: PMC8751853.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    11. Differential Expression Patterns of Lynx Proteins and Involvement of Lynx1 in Prepulse Inhibition. Front Behav Neurosci. 2021; 15:703748. Sherafat Y, Chen E, Lallai V, Bautista M, Fowler JP, Chen YC, Miwa J, Fowler CD. PMID: 34803621; PMCID: PMC8595198.
      View in: PubMed   Mentions: 4  
    12. Pharmacokinetic and pharmacodynamic properties of aerosolized ("vaped") THC in adolescent male and female rats. Psychopharmacology (Berl). 2021 Dec; 238(12):3595-3605. Ruiz CM, Torrens A, Lallai V, Castillo E, Manca L, Martinez MX, Justeson DN, Fowler CD, Piomelli D, Mahler SV. PMID: 34495367; PMCID: PMC8665923.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    13. Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization. J Clin Invest. 2021 06 15; 131(12). Sanchez II, Nguyen TB, England WE, Lim RG, Vu AQ, Miramontes R, Byrne LM, Markmiller S, Lau AL, Orellana I, Curtis MA, Faull RLM, Yeo GW, Fowler CD, Reidling JC, Wild EJ, Spitale RC, Thompson LM. PMID: 33945510; PMCID: PMC8203471.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    14. Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, nicotinic acetylcholine receptors reduces nicotine self-administration and withdrawal symptoms. Neuropharmacology. 2021 06 01; 190:108568. Hamouda AK, Bautista MR, Akinola LS, Alkhlaif Y, Jackson A, Carper M, Toma WB, Garai S, Chen YC, Thakur GA, Fowler CD, Damaj MI. PMID: 33878302; PMCID: PMC8169606.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    15. E-cigarette vape and lung ACE2 expression: Implications for coronavirus vulnerability. Environ Toxicol Pharmacol. 2021 Aug; 86:103656. Lallai V, Manca L, Fowler CD. PMID: 33838329; PMCID: PMC8025581.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    16. Multidimensional Intersection of Nicotine, Gene Expression, and Behavior. Front Behav Neurosci. 2021; 15:649129. Sherafat Y, Bautista M, Fowler CD. PMID: 33828466; PMCID: PMC8019722.
      View in: PubMed   Mentions: 5  
    17. Nicotine e-cigarette vapor inhalation and self-administration in a rodent model: Sex- and nicotine delivery-specific effects on metabolism and behavior. Addict Biol. 2021 11; 26(6):e13024. Lallai V, Chen YC, Roybal MM, Kotha ER, Fowler JP, Staben A, Cortez A, Fowler CD. PMID: 33624410; PMCID: PMC8380743.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    18. α3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake. J Neurosci. 2021 02 24; 41(8):1779-1787. Elayouby KS, Ishikawa M, Dukes AJ, Smith ACW, Lu Q, Fowler CD, Kenny PJ. PMID: 33380469; PMCID: PMC8115890.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    19. The Interpeduncular-Ventral Hippocampus Pathway Mediates Active Stress Coping and Natural Reward. eNeuro. 2020 Nov/Dec; 7(6). Sherafat Y, Bautista M, Fowler JP, Chen E, Ahmed A, Fowler CD. PMID: 33139320; PMCID: PMC7688303.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    20. Adolescent Cannabinoid and Nicotine Exposure Differentially Alters Adult Nicotine Self-Administration in Males and Females. Nicotine Tob Res. 2020 07 16; 22(8):1364-1373. Dukes AJ, Fowler JP, Lallai V, Pushkin AN, Fowler CD. PMID: 32396625; PMCID: PMC7364841.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    21. Method for Primary Epithelial Cell Culture from the Rat Choroid Plexus. Bio Protoc. 2020 Feb 20; 10(4):e3532. Lallai V, Ahmed A, Fowler CD. PMID: 33654756; PMCID: PMC7842687.
      View in: PubMed   Mentions: 6  
    22. Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models. Curr Top Behav Neurosci. 2020; 45:101-121. Gipson CD, Fowler CD. PMID: 32468493; PMCID: PMC8442880.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. Handb Exp Pharmacol. 2020; 258:373-393. Fowler CD, Turner JR, Imad Damaj M. PMID: 31267166.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    24. Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring. Addict Biol. 2021 01; 26(1):e12859. Goldberg LR, Zeid D, Kutlu MG, Cole RD, Lallai V, Sebastian A, Albert I, Fowler CD, Parikh V, Gould TJ. PMID: 31782218; PMCID: PMC8442877.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    25. NeuroEVs: Characterizing Extracellular Vesicles Generated in the Neural Domain. J Neurosci. 2019 11 20; 39(47):9262-9268. Fowler CD. PMID: 31748281; PMCID: PMC6867818.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    26. The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. J Pharmacol Exp Ther. 2020 01; 372(1):21-29. Chen YC, Fowler JP, Wang J, Watson CJW, Sherafat Y, Staben A, Lazarus P, Denton TT, Fowler CD. PMID: 31628204; PMCID: PMC6904882.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    27. Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function. eNeuro. 2019 Mar-Apr; 6(2). Lallai V, Grimes N, Fowler JP, Sequeira PA, Cartagena P, Limon A, Coutts M, Monuki ES, Bunney W, Demuro A, Fowler CD. PMID: 31119189; PMCID: PMC6529591.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    28. Cannabinoid and nicotine exposure during adolescence induces sex-specific effects on anxiety- and reward-related behaviors during adulthood. PLoS One. 2019; 14(1):e0211346. Pushkin AN, Eugene AJ, Lallai V, Torres-Mendoza A, Fowler JP, Chen E, Fowler CD. PMID: 30703155; PMCID: PMC6354968.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    29. Basic Science and Public Policy: Informed Regulation for Nicotine and Tobacco Products. Nicotine Tob Res. 2018 06 07; 20(7):789-799. Fowler CD, Gipson CD, Kleykamp BA, Rupprecht LE, Harrell PT, Rees VW, Gould TJ, Oliver J, Bagdas D, Damaj MI, Schmidt HD, Duncan A, De Biasi M, Basic Science Network (BSN) of the Society for Research on Nicotine and Tobacco (SRNT). PMID: 29065200; PMCID: PMC5991436.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    30. Altered Baseline and Nicotine-Mediated Behavioral and Cholinergic Profiles in ChAT-Cre Mouse Lines. J Neurosci. 2018 02 28; 38(9):2177-2188. Chen E, Lallai V, Sherafat Y, Grimes NP, Pushkin AN, Fowler JP, Fowler CD. PMID: 29371319; PMCID: PMC5830509.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    31. Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior. Prog Brain Res. 2017; 235:93-112. Bobadilla AC, Heinsbroek JA, Gipson CD, Griffin WC, Fowler CD, Kenny PJ, Kalivas PW. PMID: 29054293; PMCID: PMC5794216.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    32. More Than Just Chillin': Interactive Effects of Menthol and Nicotine in Drug Reward. Neuropsychopharmacology. 2017 11; 42(12):2283-2284. Lallai V, Fowler CD. PMID: 28553838; PMCID: PMC5645734.
      View in: PubMed   Mentions: 3     Fields:    
    33. GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci. 2017 May; 20(5):708-716. Tuesta LM, Chen Z, Duncan A, Fowler CD, Ishikawa M, Lee BR, Liu XA, Lu Q, Cameron M, Hayes MR, Kamenecka TM, Pletcher M, Kenny PJ. PMID: 28368384; PMCID: PMC5541856.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    34. Emerging Role of the Cerebrospinal Fluid - Neuronal Interface in Neuropathology. Neuro. 2015 Dec; 2(3):92-98. Ochoa V, Loeffler AJ, Fowler CD. PMID: 28702514; PMCID: PMC5502773.
      View in: PubMed   Mentions: 3  
    35. Nicotine aversion: Neurobiological mechanisms and relevance to tobacco dependence vulnerability. Neuropharmacology. 2014 Jan; 76 Pt B:533-44. Fowler CD, Kenny PJ. PMID: 24055497; PMCID: PMC3858456.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    36. Role of α5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice. Psychopharmacology (Berl). 2013 Aug 20. Fowler CD, Tuesta L, Kenny PJ. PMID: 23958943; PMCID: PMC3930613.
      View in: PubMed   Mentions: 46     Fields:    
    37. Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors. J Neurosci. 2013 May 01; 33(18):7728-41. Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J. PMID: 23637165; PMCID: PMC3831006.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    38. Hypocretin-1 receptors regulate the reinforcing and reward-enhancing effects of cocaine: pharmacological and behavioral genetics evidence. Front Behav Neurosci. 2012; 6:47. Hollander JA, Pham D, Fowler CD, Kenny PJ. PMID: 22837742; PMCID: PMC3402880.
      View in: PubMed   Mentions: 53  
    39. Habenular signaling in nicotine reinforcement. Neuropsychopharmacology. 2012 Jan; 37(1):306-7. Fowler CD, Kenny PJ. PMID: 22157872; PMCID: PMC3238079.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    40. Utility of genetically modified mice for understanding the neurobiology of substance use disorders. Hum Genet. 2012 Jun; 131(6):941-57. Fowler CD, Kenny PJ. PMID: 22190154; PMCID: PMC3977433.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    41. Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior. Biochem Pharmacol. 2011 Oct 15; 82(8):984-95. Tuesta LM, Fowler CD, Kenny PJ. PMID: 21740894; PMCID: PMC3163076.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    42. Intravenous nicotine self-administration and cue-induced reinstatement in mice: effects of nicotine dose, rate of drug infusion and prior instrumental training. Neuropharmacology. 2011 Sep; 61(4):687-98. Fowler CD, Kenny PJ. PMID: 21640128; PMCID: PMC3130070.
      View in: PubMed   Mentions: 58     Fields:    Translation:Animals
    43. Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature. 2011 Mar 31; 471(7340):597-601. Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. PMID: 21278726; PMCID: PMC3079537.
      View in: PubMed   Mentions: 371     Fields:    Translation:AnimalsCells
    44. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. J Exp Med. 2010 Aug 30; 207(9):1843-51. Schaefer A, Im HI, Venø MT, Fowler CD, Min A, Intrator A, Kjems J, Kenny PJ, O'Carroll D, Greengard P. PMID: 20643829; PMCID: PMC2931161.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    45. Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. Behav Pharmacol. 2008 Sep; 19(5-6):461-84. Fowler CD, Arends MA, Kenny PJ. PMID: 18690103; PMCID: PMC2669417.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    46. Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions. Ann Neurol. 2008 Apr; 63(4):428-35. Young EA, Fowler CD, Kidd GJ, Chang A, Rudick R, Fisher E, Trapp BD. PMID: 18438950.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    47. Estrogen and adult neurogenesis in the amygdala and hypothalamus. Brain Res Rev. 2008 Mar; 57(2):342-51. Fowler CD, Liu Y, Wang Z. PMID: 17764748; PMCID: PMC2373759.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    48. Estrogen regulation of cell proliferation and distribution of estrogen receptor-alpha in the brains of adult female prairie and meadow voles. J Comp Neurol. 2005 Aug 22; 489(2):166-79. Fowler CD, Johnson F, Wang Z. PMID: 15984004; PMCID: PMC3962047.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    49. Newly proliferated cells in the adult male amygdala are affected by gonadal steroid hormones. J Neurobiol. 2003 Dec; 57(3):257-69. Fowler CD, Freeman ME, Wang Z. PMID: 14608662.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    50. The effects of social environment on adult neurogenesis in the female prairie vole. J Neurobiol. 2002 May; 51(2):115-28. Fowler CD, Liu Y, Ouimet C, Wang Z. PMID: 11932953.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    51. Differential expression of vasopressin, oxytocin and corticotrophin-releasing hormone messenger RNA in the paraventricular nucleus of the prairie vole brain following stress. J Neuroendocrinol. 2001 Dec; 13(12):1059-65. Liu Y, Curtis JT, Fowler CD, Spencer C, Houpt T, Wang ZX. PMID: 11722702.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    52. Expression and estrogen regulation of brain-derived neurotrophic factor gene and protein in the forebrain of female prairie voles. J Comp Neurol. 2001 May 14; 433(4):499-514. Liu Y, Fowler CD, Young LJ, Yan Q, Insel TR, Wang Z. PMID: 11304714.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    53. Ontogeny of brain-derived neurotrophic factor gene expression in the forebrain of prairie and montane voles. Brain Res Dev Brain Res. 2001 Mar 29; 127(1):51-61. Liu Y, Fowler CD, Wang Z. PMID: 11287064.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
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