Plikus, Maksim

Title(s)Assistant Professor, Developmental & Cell Biology
Phone(949) 824-1260, (949) 824-4716
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    Collapse Research 
    Collapse Research Activities and Funding
    Multiscale Models of Wound Cell Plasticity for Regeneration
    NIH/NIAMS U01AR073159Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Induction of fat regeneration in skin wounds by hair follicle signaling
    NIH/NIAMS R01AR067273Sep 18, 2014 - Aug 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang Y, Guerrero-Juarez CF, Qiu Y, Du H, Chen W, Figueroa S, Plikus MV, Nie Q. A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing. Exp Dermatol. 2019 Feb 23. PMID: 30801791.
      View in: PubMed
    2. Tian Y, Xu J, Li Y, Zhao R, Du S, Lv C, Wu W, Liu R, Sheng X, Song Y, Bi X, Li G, Li M, Wu X, Lou P, You H, Cui W, Sun J, Shuai J, Ren F, Zhang B, Guo M, Hou X, Wu K, Xue L, Zhang H, Plikus MV, Cong Y, Lengner CJ, Liu Z, Yu Z. MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. Gastroenterology. 2019 Feb 16. PMID: 30779922.
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    3. Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nat Commun. 2019 Feb 08; 10(1):650. PMID: 30737373.
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    4. Zhang LJ, Chen SX, Guerrero-Juarez CF, Li F, Tong Y, Liang Y, Liggins M, Chen X, Chen H, Li M, Hata T, Zheng Y, Plikus MV, Gallo RL. Age-Related Loss of Innate Immune Antimicrobial Function of Dermal Fat Is Mediated by Transforming Growth Factor Beta. Immunity. 2019 Jan 15; 50(1):121-136.e5. PMID: 30594464.
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    5. Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M. Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Nat Commun. 2018 11 21; 9(1):4903. PMID: 30464171.
      View in: PubMed
    6. Plikus MV, Andersen B. Skin as a window to body-clock time. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):12095-12097. PMID: 30429317.
      View in: PubMed
    7. Haensel D, Sun P, MacLean AL, Ma X, Zhou Y, Stemmler MP, Brabletz S, Berx G, Plikus MV, Nie Q, Brabletz T, Dai X. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO Rep. 2019 Jan; 20(1). PMID: 30413481.
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    8. Hanninen AM, Prince RC, Ramos R, Plikus MV, Potma EO. High-resolution infrared imaging of biological samples with third-order sum-frequency generation microscopy. Biomed Opt Express. 2018 Oct 01; 9(10):4807-4817. PMID: 30319904.
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    9. Fan SM, Chang YT, Chen CL, Wang WH, Pan MK, Chen WP, Huang WY, Xu Z, Huang HE, Chen T, Plikus MV, Chen SK, Lin SJ. External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6880-E6889. PMID: 29959210.
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    10. Shi J, Ma X, Su Y, Song Y, Tian Y, Yuan S, Zhang X, Yang D, Zhang H, Shuai J, Cui W, Ren F, Plikus MV, Chen Y, Luo J, Yu Z. MiR-31 Mediates Inflammatory Signaling to Promote Re-Epithelialization during Skin Wound Healing. J Invest Dermatol. 2018 Oct; 138(10):2253-2263. PMID: 29605672.
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    11. Hughes MW, Jiang TX, Plikus MV, Guerrero-Juarez CF, Lin CH, Schafer C, Maxson R, Widelitz RB, Chuong CM. Msx2 Supports Epidermal Competency during Wound-Induced Hair Follicle Neogenesis. J Invest Dermatol. 2018 Sep; 138(9):2041-2050. PMID: 29577917.
      View in: PubMed
    12. Fan SM, Tsai CF, Yen CM, Lin MH, Wang WH, Chan CC, Chen CL, Phua KKL, Pan SH, Plikus MV, Yu SL, Chen YJ, Lin SJ. Inducing hair follicle neogenesis with secreted proteins enriched in embryonic skin. Biomaterials. 2018 Jun; 167:121-131. PMID: 29567388.
      View in: PubMed
    13. Guerrero-Juarez CF, Plikus MV. Emerging nonmetabolic functions of skin fat. Nat Rev Endocrinol. 2018 Mar; 14(3):163-173. PMID: 29327704.
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    14. Sulli G, Rommel A, Wang X, Kolar MJ, Puca F, Saghatelian A, Plikus MV, Verma IM, Panda S. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018 01 18; 553(7688):351-355. PMID: 29320480.
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    15. Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV. Anatomical, Physiological, and Functional Diversity of Adipose Tissue. Cell Metab. 2018 Jan 09; 27(1):68-83. PMID: 29320711.
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    16. Guerrero-Juarez CF, Astrowski AA, Murad R, Dang CT, Shatrova VO, Astrowskaja A, Lim CH, Ramos R, Wang X, Liu Y, Lee HL, Pham KT, Hsi TC, Oh JW, Crocker D, Mortazavi A, Ito M, Plikus MV. Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis. J Invest Dermatol. 2018 Jun; 138(6):1409-1419. PMID: 29317265.
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    17. Lv C, Li F, Li X, Tian Y, Zhang Y, Sheng X, Song Y, Meng Q, Yuan S, Luan L, Andl T, Feng X, Jiao B, Xu M, Plikus MV, Dai X, Lengner C, Cui W, Ren F, Shuai J, Millar SE, Yu Z. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nat Commun. 2017 10 19; 8(1):1036. PMID: 29051494.
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    18. Huang WY, Lai SF, Chiu HY, Chang M, Plikus MV, Chan CC, Chen YT, Tsao PN, Yang TL, Lee HS, Chi P, Lin SJ. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy. Cancer Res. 2017 11 15; 77(22):6083-6096. PMID: 28939680.
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    19. Tian Y, Ma X, Lv C, Sheng X, Li X, Zhao R, Song Y, Andl T, Plikus MV, Sun J, Ren F, Shuai J, Lengner CJ, Cui W, Yu Z. Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis. Elife. 2017 09 05; 6. PMID: 28870287.
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    20. Wang Q, Oh JW, Lee HL, Dhar A, Peng T, Ramos R, Guerrero-Juarez CF, Wang X, Zhao R, Cao X, Le J, Fuentes MA, Jocoy SC, Rossi AR, Vu B, Pham K, Wang X, Mali NM, Park JM, Choi JH, Lee H, Legrand JMD, Kandyba E, Kim JC, Kim M, Foley J, Yu Z, Kobielak K, Andersen B, Khosrotehrani K, Nie Q, Plikus MV. A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning. Elife. 2017 07 11; 6. PMID: 28695824.
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    21. Guerrero-Juarez CF, Plikus MV. Gli-fully Halting the Progression of Fibrosis. Cell Stem Cell. 2017 Jun 01; 20(6):735-736. PMID: 28575684.
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    22. Wu HJ, Oh JW, Spandau DF, Tholpady S, Diaz J, Schroeder LJ, Offutt CD, Glick AB, Plikus MV, Koyama S, Foley J. Estrogen modulates mesenchyme-epidermis interactions in the adult nipple. Development. 2017 04 15; 144(8):1498-1509. PMID: 28289136.
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    23. Ma X, Tian Y, Song Y, Shi J, Xu J, Xiong K, Li J, Xu W, Zhao Y, Shuai J, Chen L, Plikus MV, Lengner CJ, Ren F, Xue L, Yu Z. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway. J Invest Dermatol. 2017 05; 137(5):1015-1024. PMID: 28143780.
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    24. Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, Hsi TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G. Regeneration of fat cells from myofibroblasts during wound healing. Science. 2017 02 17; 355(6326):748-752. PMID: 28059714.
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    25. Sun Z, Plikus MV, Komarova NL. Near Equilibrium Calculus of Stem Cells in Application to the Airway Epithelium Lineage. PLoS Comput Biol. 2016 07; 12(7):e1004990. PMID: 27427948.
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    26. Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. A Guide to Studying Human Hair Follicle Cycling In Vivo. J Invest Dermatol. 2016 Jan; 136(1):34-44. PMID: 26763421.
      View in: PubMed
    27. Yang J, Plikus MV, Komarova NL. The Role of Symmetric Stem Cell Divisions in Tissue Homeostasis. PLoS Comput Biol. 2015 Dec; 11(12):e1004629. PMID: 26700130; PMCID: PMC4689538.
    28. Al Alam D, El Agha E, Sakurai R, Kheirollahi V, Moiseenko A, Danopoulos S, Shrestha A, Schmoldt C, Quantius J, Herold S, Chao CM, Tiozzo C, De Langhe S, Plikus MV, Thornton M, Grubbs B, Minoo P, Rehan VK, Bellusci S. Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Dec 01; 142(23):4139-50. PMID: 26511927; PMCID: PMC4712831 [Available on 12/01/16].
    29. Beasley SM, Plikus MV, Spitale RC, Pedersen IM. The emerging functions of regulatory RNA species in skin biology. Exp Dermatol. 2015 Nov; 24(11):827-8. PMID: 26309056; PMCID: PMC4715513 [Available on 11/01/16].
    30. Oh JW, Chung O, Cho YS, MacGregor GR, Plikus MV. Gene loss in keratinization programs accompanies adaptation of cetacean skin to aquatic lifestyle. Exp Dermatol. 2015 Aug; 24(8):572-3. PMID: 25959646; PMCID: PMC4520764.
    31. Chen CC, Plikus MV, Tang PC, Widelitz RB, Chuong CM. The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration. J Mol Biol. 2016 Apr 10; 428(7):1423-40. PMID: 26196442.
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    32. Wang X, Hsi TC, Guerrero-Juarez CF, Pham K, Cho K, McCusker CD, Monuki ES, Cho KW, Gay DL, Plikus MV. Principles and mechanisms of regeneration in the mouse model for wound-induced hair follicle neogenesis. Regeneration (Oxf). 2015 Aug; 2(4):169-181. PMID: 26504521.
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    33. Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S, Widelitz RB, Lander AD, Chuong CM. Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell. 2015 Apr 09; 161(2):277-90. PMID: 25860610; PMCID: PMC4393531.
    34. Oh JW, Lin SJ, Plikus MV. Regenerative metamorphosis in hairs and feathers: follicle as a programmable biological printer. Exp Dermatol. 2015 Apr; 24(4):262-4. PMID: 25557541; PMCID: PMC4403872.
    35. Plikus MV, Van Spyk EN, Pham K, Geyfman M, Kumar V, Takahashi JS, Andersen B. The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity. J Biol Rhythms. 2015 Jun; 30(3):163-82. PMID: 25589491; PMCID: PMC4441597.
    36. Zhang LJ, Guerrero-Juarez CF, Hata T, Bapat SP, Ramos R, Plikus MV, Gallo RL. Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science. 2015 Jan 02; 347(6217):67-71. PMID: 25554785.
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    37. Geyfman M, Plikus MV, Treffeisen E, Andersen B, Paus R. Resting no more: re-defining telogen, the maintenance stage of the hair growth cycle. Biol Rev Camb Philos Soc. 2015 Nov; 90(4):1179-96. PMID: 25410793; PMCID: PMC4437968 [Available on 11/01/16].
    38. Plikus MV, Guerrero-Juarez CF, Treffeisen E, Gay DL. Epigenetic control of skin and hair regeneration after wounding. Exp Dermatol. 2015 Mar; 24(3):167-70. PMID: 25039994; PMCID: PMC4289120.
    39. Gay DL, Yang CC, Plikus MV, Ito M, Rivera C, Treffeisen E, Doherty L, Spata M, Millar SE, Cotsarelis G. CD133 expression correlates with membrane beta-catenin and E-cadherin loss from human hair follicle placodes during morphogenesis. J Invest Dermatol. 2015 Jan; 135(1):45-55. PMID: 25010141; PMCID: PMC4465595.
    40. Plikus MV, Astrowski AA. Deadly hairs, lethal feathers--convergent evolution of poisonous integument in mammals and birds. Exp Dermatol. 2014 Jul; 23(7):466-8. PMID: 24698054.
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    41. Guerrero-Juarez CF, Ramos R, Oh JW, Hsi TC, Plikus MV. Light-emitting hair follicles: studying skin regeneration with in vivo imaging. J Invest Dermatol. 2014 Jun; 134(6):1496-1498. PMID: 24825056; PMCID: PMC4266601.
    42. Plikus MV. At the dawn of hair research - testing the limits of hair follicle regeneration. Exp Dermatol. 2014 May; 23(5):314-5. PMID: 24494858.
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    43. Chen CC, Murray PJ, Jiang TX, Plikus MV, Chang YT, Lee OK, Widelitz RB, Chuong CM. Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4. J Invest Dermatol. 2014 Aug; 134(8):2086-2096. PMID: 24618599; PMCID: PMC4102635.
    44. Plikus MV, Chuong CM. Macroenvironmental regulation of hair cycling and collective regenerative behavior. Cold Spring Harb Perspect Med. 2014 Jan 01; 4(1):a015198. PMID: 24384813; PMCID: PMC3869280.
    45. Oh JW, Hsi TC, Guerrero-Juarez CF, Ramos R, Plikus MV. Organotypic skin culture. J Invest Dermatol. 2013 Nov; 133(11):1-4. PMID: 24129782; PMCID: PMC4068613.
    46. Ramos R, Guerrero-Juarez CF, Plikus MV. Hair follicle signaling networks: a dermal papilla-centric approach. J Invest Dermatol. 2013 Oct; 133(10):2306-2308. PMID: 24030645; PMCID: PMC4094135.
    47. Gay D, Kwon O, Zhang Z, Spata M, Plikus MV, Holler PD, Ito M, Yang Z, Treffeisen E, Kim CD, Nace A, Zhang X, Baratono S, Wang F, Ornitz DM, Millar SE, Cotsarelis G. Fgf9 from dermal ?d T cells induces hair follicle neogenesis after wounding. Nat Med. 2013 Jul; 19(7):916-23. PMID: 23727932; PMCID: PMC4054871.
    48. Plikus MV, Vollmers C, de la Cruz D, Chaix A, Ramos R, Panda S, Chuong CM. Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci U S A. 2013 Jun 04; 110(23):E2106-15. PMID: 23690597; PMCID: PMC3677499.
    49. Murray PJ, Maini PK, Plikus MV, Chuong CM, Baker RE. Modelling hair follicle growth dynamics as an excitable medium. PLoS Comput Biol. 2012; 8(12):e1002804. PMID: 23284275; PMCID: PMC3527291.
    50. Plikus MV, Gay DL, Treffeisen E, Wang A, Supapannachart RJ, Cotsarelis G. Epithelial stem cells and implications for wound repair. Semin Cell Dev Biol. 2012 Dec; 23(9):946-53. PMID: 23085626; PMCID: PMC3518754.
    51. Plikus MV. New activators and inhibitors in the hair cycle clock: targeting stem cells' state of competence. J Invest Dermatol. 2012 May; 132(5):1321-4. PMID: 22499035; PMCID: PMC4033821.
    52. Plikus MV, Baker RE, Chen CC, Fare C, de la Cruz D, Andl T, Maini PK, Millar SE, Widelitz R, Chuong CM. Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science. 2011 Apr 29; 332(6029):586-9. PMID: 21527712; PMCID: PMC3321266.
    53. Yeh J, Green LM, Jiang TX, Plikus M, Huang E, Chang RN, Hughes MW, Chuong CM, Tuan TL. Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2. Wound Repair Regen. 2009 Sep-Oct; 17(5):639-48. PMID: 19769717; PMCID: PMC3074593.
    54. Plikus MV, Widelitz RB, Maxson R, Chuong CM. Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity. Int J Dev Biol. 2009; 53(5-6):857-68. PMID: 19378257; PMCID: PMC2759942.
    55. Plikus MV, Chuong CM. Complex hair cycle domain patterns and regenerative hair waves in living rodents. J Invest Dermatol. 2008 May; 128(5):1071-80. PMID: 18094733; PMCID: PMC2705329.
    56. Plikus MV, Mayer JA, de la Cruz D, Baker RE, Maini PK, Maxson R, Chuong CM. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008 Jan 17; 451(7176):340-4. PMID: 18202659; PMCID: PMC2696201.
    57. Wang XP, Suomalainen M, Felszeghy S, Zelarayan LC, Alonso MT, Plikus MV, Maas RL, Chuong CM, Schimmang T, Thesleff I. An integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol. 2007 Jun; 5(6):e159. PMID: 17564495; PMCID: PMC1885832.
    58. Plikus MV, Zhang Z, Chuong CM. PubFocus: semantic MEDLINE/PubMed citations analytics through integration of controlled biomedical dictionaries and ranking algorithm. BMC Bioinformatics. 2006 Oct 02; 7:424. PMID: 17014720; PMCID: PMC1618408.
    59. Widelitz RB, Baker RE, Plikus M, Lin CM, Maini PK, Paus R, Chuong CM. Distinct mechanisms underlie pattern formation in the skin and skin appendages. Birth Defects Res C Embryo Today. 2006 Sep; 78(3):280-91. PMID: 17061271; PMCID: PMC4380182.
    60. Chuong CM, Wu P, Plikus M, Jiang TX, Bruce Widelitz R. Engineering stem cells into organs: topobiological transformations demonstrated by beak, feather, and other ectodermal organ morphogenesis. Curr Top Dev Biol. 2006; 72:237-74. PMID: 16564337; PMCID: PMC4382027.
    61. Plikus MV, Zeichner-David M, Mayer JA, Reyna J, Bringas P, Thewissen JG, Snead ML, Chai Y, Chuong CM. Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev. 2005 Sep-Oct; 7(5):440-57. PMID: 16174037; PMCID: PMC4386657.
    62. Plikus M, Chuong CM. Making waves with hairs. J Invest Dermatol. 2004 Apr; 122(4):vii-ix. PMID: 15102103; PMCID: PMC4378646.
    63. Plikus M, Wang WP, Liu J, Wang X, Jiang TX, Chuong CM. Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol. 2004 Mar; 164(3):1099-114. PMID: 14982863; PMCID: PMC1614723.
    64. Wu P, Hou L, Plikus M, Hughes M, Scehnet J, Suksaweang S, Widelitz R, Jiang TX, Chuong CM. Evo-Devo of amniote integuments and appendages. Int J Dev Biol. 2004; 48(2-3):249-70. PMID: 15272390.
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    65. Ma L, Liu J, Wu T, Plikus M, Jiang TX, Bi Q, Liu YH, Müller-Röver S, Peters H, Sundberg JP, Maxson R, Maas RL, Chuong CM. 'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development. 2003 Jan; 130(2):379-89. PMID: 12466204; PMCID: PMC4386654.