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Lawson, Devon A

TitleAssistant Professor
InstitutionUniversity of California, Irvine
DepartmentPhysiology and Biophysics
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-4113
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    Collapse Research 
    Collapse Research Activities and Funding
    Single-cell analysis of intratumor heterogeneity in metastasis
    NIH/NCI K22CA190511Sep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson D, Werb Z, Kessenbrock K. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 May 23; 9(1):2028. PMID: 29795293.
      View in: PubMed
    2. Takai K, Drain AP, Lawson D, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018 Feb 01; 32(3-4):244-257. PMID: 29483153.
      View in: PubMed
    3. Sun Z, Wang CY, Lawson D, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Oncotarget. 2018 Feb 16; 9(13):10945-10961. PMID: 29541388.
      View in: PubMed
    4. Parker I, Evans KT, Ellefsen K, Lawson D, Smith IF. Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases. Sci Rep. 2017 Sep 08; 7(1):11029. PMID: 28887508.
      View in: PubMed
    5. Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, S├ęgaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson D, Digman MA, Zhao W. Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 Jul 26; 9(400). PMID: 28747514.
      View in: PubMed
    6. Shahi P, Wang CY, Lawson D, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3169-3174. PMID: 28258171.
      View in: PubMed
    7. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson D, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329. PMID: 27775705.
      View in: PubMed
    8. Lawson D, Werb Z, Zong Y, Goldstein AS. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.prot078071. PMID: 26631119; PMCID: PMC4965229 [Available on 12/02/16].
    9. Lawson D, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. PMID: 26416748; PMCID: PMC4648562.
    10. Sun Z, Lawson D, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels?. Biotechnol Rep (Amst). 2015 Sep; 7:157-165. PMID: 26989654.
      View in: PubMed
    11. Kessenbrock K, Dijkgraaf GJ, Lawson D, Littlepage LE, Shahi P, Pieper U, Werb Z. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 05; 13(3):300-13. PMID: 23871604; PMCID: PMC3769456.
    12. Plaks V, Brenot A, Lawson D, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. PMID: 23352663; PMCID: PMC3563842.
    13. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson D, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51. PMID: 22728437; PMCID: PMC3546490.
    14. Lukacs RU, Goldstein AS, Lawson D, Cheng D, Witte ON. Isolation, cultivation and characterization of adult murine prostate stem cells. Nat Protoc. 2010 Apr; 5(4):702-13. PMID: 20360765; PMCID: PMC2943378.
    15. Lawson D, Zong Y, Memarzadeh S, Xin L, Huang J, Witte ON. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2610-5. PMID: 20133806; PMCID: PMC2823887.
    16. Zong Y, Xin L, Goldstein AS, Lawson D, Teitell MA, Witte ON. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12465-70. PMID: 19592505.
      View in: PubMed
    17. Goldstein AS, Lawson D, Cheng D, Sun W, Garraway IP, Witte ON. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20882-7. PMID: 19088204.
      View in: PubMed
    18. Lawson D, Witte ON. Stem cells in prostate cancer initiation and progression. J Clin Invest. 2007 Aug; 117(8):2044-50. PMID: 17671638; PMCID: PMC1934594.
    19. Xin L, Lukacs RU, Lawson D, Cheng D, Witte ON. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells. 2007 Nov; 25(11):2760-9. PMID: 17641240.
      View in: PubMed
    20. Lawson D, Xin L, Lukacs RU, Cheng D, Witte ON. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):181-6. PMID: 17185413; PMCID: PMC1716155.
    21. Xin L, Teitell MA, Lawson D, Kwon A, Mellinghoff IK, Witte ON. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7789-94. PMID: 16682621; PMCID: PMC1458510.
    22. Wang S, Garcia AJ, Wu M, Lawson D, Witte ON, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1480-5. PMID: 16432235; PMCID: PMC1345717.
    23. Xin L, Lawson D, Witte ON. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6942-7. PMID: 15860580; PMCID: PMC1087514.
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