Devon A Lawson

Title(s)Associate Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-2991
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    Collapse Research 
    Collapse Research Activities and Funding
    Inflammatory microenvironment in brain metastasis
    NIH R01CA237376Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    Single-cell analysis of intratumor heterogeneity in metastasis
    NIH K22CA190511Sep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microglia promote anti-tumour immunity and suppress breast cancer brain metastasis. Nat Cell Biol. 2023 Dec; 25(12):1848-1859. Evans KT, Blake K, Longworth A, Coburn MA, Insua-Rodríguez J, McMullen TP, Nguyen QH, Ma D, Lev T, Hernandez GA, Oganyan AK, Orujyan D, Edwards RA, Pridans C, Green KN, Villalta SA, Blurton-Jones M, Lawson DA. PMID: 37957324.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. A spatially resolved single-cell genomic atlas of the adult human breast. Nature. 2023 Aug; 620(7972):181-191. Kumar T, Nee K, Wei R, He S, Nguyen QH, Bai S, Blake K, Pein M, Gong Y, Sei E, Hu M, Casasent AK, Thennavan A, Li J, Tran T, Chen K, Nilges B, Kashikar N, Braubach O, Ben Cheikh B, Nikulina N, Chen H, Teshome M, Menegaz B, Javaid H, Nagi C, Montalvan J, Lev T, Mallya S, Tifrea DF, Edwards R, Lin E, Parajuli R, Hanson S, Winocour S, Thompson A, Lim B, Lawson DA, Kessenbrock K, Navin N. PMID: 37380767.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    3. Signalling by senescent melanocytes hyperactivates hair growth. Nature. 2023 Jun; 618(7966):808-817. Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV. PMID: 37344645; PMCID: PMC10284692.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    4. A spatially resolved single cell genomic atlas of the adult human breast. bioRxiv. 2023 Apr 25. Kumar T, Nee K, Wei R, He S, Nguyen QH, Bai S, Blake K, Gong Y, Pein M, Sei E, Hu M, Casasent A, Thennavan A, Li J, Tran T, Chen K, Nilges B, Kashikar N, Braubach O, Cheikh BB, Nikulina N, Chen H, Teshome M, Menegaz B, Javaid H, Nagi C, Montalvan J, Tifrea DF, Edwards R, Lin E, Parajuli R, Winocour S, Thompson A, Lim B, Lawson DA, Kessenbrock K, Navin N. PMID: 37163043; PMCID: PMC10168262.
      View in: PubMed   Mentions:
    5. Author Correction: Automated segmentation and tracking of mitochondria in live-cell time-lapse images. Nat Methods. 2022 Jun; 19(6):770. Lefebvre AEYT, Ma D, Kessenbrock K, Lawson DA, Digman MA. PMID: 35487982.
      View in: PubMed   Mentions:    Fields:    
    6. Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis. Commun Biol. 2021 11 05; 4(1):1268. Ma D, Hernandez GA, Lefebvre AEYT, Alshetaiwi H, Blake K, Dave KR, Rauf M, Williams JW, Davis RT, Evans KT, Longworth A, Masoud MYG, Lee R, Edwards RA, Digman MA, Kessenbrock K, Lawson DA. PMID: 34741115; PMCID: PMC8571269.
      View in: PubMed   Mentions: 5  Translation:Animals
    7. Automated segmentation and tracking of mitochondria in live-cell time-lapse images. Nat Methods. 2021 09; 18(9):1091-1102. Lefebvre AEYT, Ma D, Kessenbrock K, Lawson DA, Digman MA. PMID: 34413523.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    8. An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Lab Chip. 2021 04 07; 21(7):1333-1351. Hachey SJ, Movsesyan S, Nguyen QH, Burton-Sojo G, Tankazyan A, Wu J, Hoang T, Zhao D, Wang S, Hatch MM, Celaya E, Gomez S, Chen GT, Davis RT, Nee K, Pervolarakis N, Lawson DA, Kessenbrock K, Lee AP, Lowengrub J, Waterman ML, Hughes CCW. PMID: 33605955; PMCID: PMC8525497.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    9. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 2020 03; 22(3):310-320. Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA. PMID: 32144411.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    10. Tumour heterogeneity and metastasis at single-cell resolution. Nat Cell Biol. 2018 12; 20(12):1349-1360. Lawson DA, Kessenbrock K, Davis RT, Pervolarakis N, Werb Z. PMID: 30482943; PMCID: PMC6477686.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansCells
    11. Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity. Nat Commun. 2018 05 23; 9(1):2028. Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K. PMID: 29795293; PMCID: PMC5966421.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansCells
    12. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018 02 01; 32(3-4):244-257. Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. PMID: 29483153; PMCID: PMC5859966.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    13. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Oncotarget. 2018 Feb 16; 9(13):10945-10961. Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. PMID: 29541388; PMCID: PMC5834272.
      View in: PubMed   Mentions: 30     Fields:    
    14. Lattice light sheet imaging of membrane nanotubes between human breast cancer cells in culture and in brain metastases. Sci Rep. 2017 09 08; 7(1):11029. Parker I, Evans KT, Ellefsen K, Lawson DA, Smith IF. PMID: 28887508; PMCID: PMC5591308.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 07 26; 9(400). Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W. PMID: 28747514; PMCID: PMC5890431.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    16. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3169-3174. Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. PMID: 28258171; PMCID: PMC5373372.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    17. PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression. Nat Med. 2016 11; 22(11):1321-1329. Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. PMID: 27775705; PMCID: PMC5341692.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    18. The Cleared Mammary Fat Pad Transplantation Assay for Mammary Epithelial Organogenesis. Cold Spring Harb Protoc. 2015 Dec 02; 2015(12):pdb.prot078071. Lawson DA, Werb Z, Zong Y, Goldstein AS. PMID: 26631119; PMCID: PMC4965229.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature. 2015 Oct 01; 526(7571):131-5. Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z. PMID: 26416748; PMCID: PMC4648562.
      View in: PubMed   Mentions: 453     Fields:    Translation:HumansAnimalsCells
    20. Endovascular biopsy: Strategy for analyzing gene expression profiles of individual endothelial cells obtained from human vessels✩. Biotechnol Rep (Amst). 2015 Sep; 7:157-165. Sun Z, Lawson DA, Sinclair E, Wang CY, Lai MD, Hetts SW, Higashida RT, Dowd CF, Halbach VV, Werb Z, Su H, Cooke DL. PMID: 26989654; PMCID: PMC4792280.
      View in: PubMed   Mentions: 5  
    21. A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway. Cell Stem Cell. 2013 Sep 05; 13(3):300-13. Kessenbrock K, Dijkgraaf GJ, Lawson DA, Littlepage LE, Shahi P, Pieper U, Werb Z. PMID: 23871604; PMCID: PMC3769456.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    22. Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis. Cell Rep. 2013 Jan 31; 3(1):70-8. Plaks V, Brenot A, Lawson DA, Linnemann JR, Van Kappel EC, Wong KC, de Sauvage F, Klein OD, Werb Z. PMID: 23352663; PMCID: PMC3563842.
      View in: PubMed   Mentions: 114     Fields:    Translation:Animals
    23. The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov. 2012 Jul; 2(7):638-51. Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z. PMID: 22728437; PMCID: PMC3546490.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    24. Isolation, cultivation and characterization of adult murine prostate stem cells. Nat Protoc. 2010 Apr; 5(4):702-13. Lukacs RU, Goldstein AS, Lawson DA, Cheng D, Witte ON. PMID: 20360765; PMCID: PMC2943378.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    25. Basal epithelial stem cells are efficient targets for prostate cancer initiation. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2610-5. Lawson DA, Zong Y, Memarzadeh S, Xin L, Huang J, Witte ON. PMID: 20133806; PMCID: PMC2823887.
      View in: PubMed   Mentions: 152     Fields:    Translation:HumansAnimalsCells
    26. ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12465-70. Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA, Witte ON. PMID: 19592505; PMCID: PMC2708977.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    27. Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20882-7. Goldstein AS, Lawson DA, Cheng D, Sun W, Garraway IP, Witte ON. PMID: 19088204; PMCID: PMC2603432.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    28. Epithelial stem cells of the prostate and their role in cancer progression. Cold Spring Harb Symp Quant Biol. 2008; 73:491-502. Lukacs RU, Lawson DA, Xin L, Zong Y, Garraway I, Goldstein AS, Memarzadeh S, Witte ON. PMID: 19022743.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    29. Stem cells in prostate cancer initiation and progression. J Clin Invest. 2007 Aug; 117(8):2044-50. Lawson DA, Witte ON. PMID: 17671638; PMCID: PMC1934594.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    30. Self-renewal and multilineage differentiation in vitro from murine prostate stem cells. Stem Cells. 2007 Nov; 25(11):2760-9. Xin L, Lukacs RU, Lawson DA, Cheng D, Witte ON. PMID: 17641240.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    31. Isolation and functional characterization of murine prostate stem cells. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):181-6. Lawson DA, Xin L, Lukacs RU, Cheng D, Witte ON. PMID: 17185413; PMCID: PMC1716155.
      View in: PubMed   Mentions: 214     Fields:    Translation:AnimalsCells
    32. Progression of prostate cancer by synergy of AKT with genotropic and nongenotropic actions of the androgen receptor. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7789-94. Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK, Witte ON. PMID: 16682621; PMCID: PMC1458510.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    33. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1480-5. Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. PMID: 16432235; PMCID: PMC1345717.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    34. The Sca-1 cell surface marker enriches for a prostate-regenerating cell subpopulation that can initiate prostate tumorigenesis. Proc Natl Acad Sci U S A. 2005 May 10; 102(19):6942-7. Xin L, Lawson DA, Witte ON. PMID: 15860580; PMCID: PMC1087514.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    35. Prostate stem cells and prostate cancer. Cold Spring Harb Symp Quant Biol. 2005; 70:187-96. Lawson DA, Xin L, Lukacs R, Xu Q, Cheng D, Witte ON. PMID: 16869753.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
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