Wendy F. Liu

Title(s)Associate Professor, Biomedical Engineering
Address2412 Engineering III
Zot 2730
Irvine CA 92697
Phone(949) 824-1682
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of microglia by tissue stiffness and Piezo1 in Alzheimer's disease
    NIH R21AG069067Sep 30, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Biophysical regulation of macrophage function
    NIH R01AI151301Sep 22, 2020 - Aug 31, 2025
    Role: Principal Investigator
    Mechanical regulation of skin repair and regeneration
    NIH R21AR077288Jul 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Epigenetic regulation of macrophage response to biomaterial implants
    NIH R21EB027840Apr 18, 2019 - Jan 31, 2021
    Role: Co-Principal Investigator
    Mechanochemical regulation of macrophages by the extracellular matrix during wound healing
    NIH R21AI128519Jun 1, 2017 - May 31, 2019
    Role: Principal Investigator
    Engineering Biomaterials to Exert Molecular Control of Immune Cell Function
    NIH DP2DE023319Sep 30, 2012 - Aug 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing. Nat Commun. 2021 05 31; 12(1):3256. Atcha H, Jairaman A, Holt JR, Meli VS, Nagalla RR, Veerasubramanian PK, Brumm KT, Lim HE, Othy S, Cahalan MD, Pathak MM, Liu WF. PMID: 34059671.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Sci Adv. 2020 Dec; 6(49). Meli VS, Atcha H, Veerasubramanian PK, Nagalla RR, Luu TU, Chen EY, Guerrero-Juarez CF, Yamaga K, Pandori W, Hsieh JY, Downing TL, Fruman DA, Lodoen MB, Plikus MV, Wang W, Liu WF. PMID: 33277245.
      View in: PubMed   Mentions: 2     Fields:    
    3. Biophysical and epigenetic regulation of cancer stemness, invasiveness and immune action. Curr Tissue Microenviron Rep. 2020 Dec; 1(4):277-300. Veerasubramanian PK, Trinh A, Akhtar N, Liu WF, Downing TL. PMID: 33817661.
      View in: PubMed   Mentions:
    4. Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation. Front Bioeng Biotechnol. 2020; 8:747. Rowley AT, Meli VS, Wu-Woods NJ, Chen EY, Liu WF, Wang SW. PMID: 32719788.
      View in: PubMed   Mentions:
    5. Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation. APL Bioeng. 2019 Mar; 3(1):016103. Hsieh JY, Keating MT, Smith TD, Meli VS, Botvinick EL, Liu WF. PMID: 31069336.
      View in: PubMed   Mentions:
    6. Biophysical regulation of macrophages in health and disease. J Leukoc Biol. 2019 08; 106(2):283-299. Meli VS, Veerasubramanian PK, Atcha H, Reitz Z, Downing TL, Liu WF. PMID: 30861205.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    7. Extracellular Matrix-Based Strategies for Immunomodulatory Biomaterials Engineering. Adv Healthc Mater. 2019 04; 8(8):e1801578. Rowley AT, Nagalla RR, Wang SW, Liu WF. PMID: 30714328.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    8. Pushing the limits of detection for proteins secreted from single cells using quantum dots. Analyst. 2019 Jan 28; 144(3):980-989. Herrera V, Hsu SJ, Rahim MK, Chen C, Nguyen L, Liu WF, Haun JB. PMID: 30270391.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. Control by cell size. Nat Mater. 2018 12; 17(12):1055-1056. Liu WF. PMID: 30470831.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    10. A Low-Cost Mechanical Stretching Device for Uniaxial Strain of Cells: A Platform for Pedagogy in Mechanobiology. J Biomech Eng. 2018 08 01; 140(8). Atcha H, Davis CT, Sullivan NR, Smith TD, Anis S, Dahbour WZ, Robinson ZR, Grosberg A, Liu WF. PMID: 30003248.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Incorporation of a Ligand Peptide for Immune Inhibitory Receptor LAIR-1 on Biomaterial Surfaces Inhibits Macrophage Inflammatory Responses. Adv Healthc Mater. 2017 Dec; 6(24). Kim YK, Chu SH, Hsieh JY, Kamoku CM, Tenner AJ, Liu WF, Wang SW. PMID: 29083540.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Harnessing macrophage plasticity for tissue regeneration. Adv Drug Deliv Rev. 2017 05 15; 114:193-205. Smith TD, Nagalla RR, Chen EY, Liu WF. PMID: 28449872.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    13. Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomater. 2017 01 01; 47:14-24. Hsieh JY, Smith TD, Meli VS, Tran TN, Botvinick EL, Liu WF. PMID: 27662809.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    14. Regulation of macrophage polarization and plasticity by complex activation signals. Integr Biol (Camb). 2016 09 12; 8(9):946-55. Smith TD, Tse MJ, Read EL, Liu WF. PMID: 27492191.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    15. Macrophage secretion heterogeneity in engineered microenvironments revealed using a microwell platform. Integr Biol (Camb). 2016 07 11; 8(7):751-60. McWhorter FY, Smith TD, Luu TU, Rahim MK, Haun JB, Liu WF. PMID: 27291691.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy. J Biomed Opt. 2016 Apr 30; 21(4):46005. Alfonso-García A, Smith TD, Datta R, Luu TU, Gratton E, Potma EO, Liu WF. PMID: 27086689.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    17. Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles. Biomater Sci. 2016 Jun 24; 4(6):948-52. Wang T, Luu TU, Chen A, Khine M, Liu WF. PMID: 27125253.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    18. Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype. ACS Appl Mater Interfaces. 2015 Dec 30; 7(51):28665-72. Luu TU, Gott SC, Woo BW, Rao MP, Liu WF. PMID: 26605491.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    19. Biomolecular strategies to modulate the macrophage response to implanted materials. J Mater Chem B. 2016 Mar 07; 4(9):1600-1609. Kim YK, Chen EY, Liu WF. PMID: 32263014.
      View in: PubMed   Mentions: 5     Fields:    
    20. Physical and mechanical regulation of macrophage phenotype and function. Cell Mol Life Sci. 2015 Apr; 72(7):1303-16. McWhorter FY, Davis CT, Liu WF. PMID: 25504084.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    21. Modification of biomaterials with a self-protein inhibits the macrophage response. Adv Healthc Mater. 2014 Jul; 3(7):989-94. Kim YK, Que R, Wang SW, Liu WF. PMID: 24573988.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    22. Real-time imaging of Toxoplasma-infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. 2014 Apr; 16(4):580-95. Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB. PMID: 24245749.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    23. Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17253-8. McWhorter FY, Wang T, Nguyen P, Chung T, Liu WF. PMID: 24101477.
      View in: PubMed   Mentions: 265     Fields:    Translation:AnimalsCells
    24. Inflammatory response assessment of a hybrid tissue-engineered heart valve leaflet. Ann Biomed Eng. 2013 Feb; 41(2):316-26. Alavi SH, Liu WF, Kheradvar A. PMID: 23053298.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    25. Mechanical regulation of cellular phenotype: implications for vascular tissue regeneration. Cardiovasc Res. 2012 Jul 15; 95(2):215-22. Liu WF. PMID: 22628449.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    26. Manipulation of cell-cell adhesion using bowtie-shaped microwells. Methods Mol Biol. 2007; 370:1-10. Nelson CM, Liu WF, Chen CS. PMID: 17416983.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    27. Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11594-9. Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS. PMID: 16049098.
      View in: PubMed   Mentions: 269     Fields:    Translation:AnimalsCells
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