Anna Grosberg

Title(s)	Associate Professor, Biomedical Engineering
Phone	(949) 824-3211
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Research

Research Activities and Funding

Cardiac Functional and Structural Implications of Lamin A/C Mutations
NIH/NHLBI R01HL129008Sep 4, 2015 - Apr 30, 2020
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Atcha H, Davis CT, Sullivan NR, Smith TD, Anis S, Dahbour WZ, Robinson ZR, Grosberg A, Liu WF. A Low-Cost Mechanical Stretching Device for Uniaxial Strain of Cells: A Platform for Pedagogy in Mechanobiology. J Biomech Eng. 2018 Aug 01; 140(8). PMID: 30003248.

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Core JQ, Mehrabi M, Robinson ZR, Ochs AR, McCarthy LA, Zaragoza MV, Grosberg A. Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations. PLoS One. 2017; 12(11):e0188256. PMID: 29149195.

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Zaragoza MV, Nguyen CHH, Widyastuti HP, McCarthy LA, Grosberg A. Dupuytren's and Ledderhose Diseases in a Family with LMNA-Related Cardiomyopathy and a Novel Variant in the ASTE1 Gene. Cells. 2017 Nov 01; 6(4). PMID: 29104234.

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Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Exp Biol Med (Maywood). 2017 11; 242(17):1643-1656. PMID: 28343439.

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Drew NK, Johnsen NE, Core JQ, Grosberg A. Multiscale Characterization of Engineered Cardiac Tissue Architecture. J Biomech Eng. 2016 11 01; 138(11). PMID: 27617880.

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Zaragoza MV, Fung L, Jensen E, Oh F, Cung K, McCarthy LA, Tran CK, Hoang V, Hakim SA, Grosberg A. Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. PLoS One. 2016; 11(5):e0155421. PMID: 27182706.

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Knight MB, Drew NK, McCarthy LA, Grosberg A. Emergent Global Contractile Force in Cardiac Tissues. Biophys J. 2016 Apr 12; 110(7):1615-1624. PMID: 27074686.

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Drew NK, Eagleson MA, Baldo DB, Parker KK, Grosberg A. Metrics for assessing cytoskeletal orientational correlations and consistency. PLoS Comput Biol. 2015 Apr; 11(4):e1004190. PMID: 25849553; PMCID: PMC4388480.

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Drew NK, Grosberg A. Methods of myofibrillogenesis modeling. Methods Mol Biol. 2015; 1299:75-91. PMID: 25836576.

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Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK. Quality metrics for stem cell-derived cardiac myocytes. Stem Cell Reports. 2014 Mar 11; 2(3):282-94. PMID: 24672752.

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Chen A, Lee E, Tu R, Santiago K, Grosberg A, Fowlkes C, Khine M. Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells. Biomaterials. 2014 Jan; 35(2):675-83. PMID: 24144905.

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McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK. Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9770-5. PMID: 23716679.

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Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol. 2012 Aug; 30(8):792-7. PMID: 22820316.

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Sheehy SP, Grosberg A, Parker KK. The contribution of cellular mechanotransduction to cardiomyocyte form and function. Biomech Model Mechanobiol. 2012 Nov; 11(8):1227-39. PMID: 22772714; PMCID: PMC3786397.

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Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK. Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials. 2012 Aug; 33(23):5732-41. PMID: 22594976; PMCID: PMC4026933.

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Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. Muscle on a chip: in vitro contractility assays for smooth and striated muscle. J Pharmacol Toxicol Methods. 2012 May-Jun; 65(3):126-35. PMID: 22521339; PMCID: PMC4184427.

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Shim J, Grosberg A, Nawroth JC, Parker KK, Bertoldi K. Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior. J Biomech. 2012 Mar 15; 45(5):832-41. PMID: 22236531; PMCID: PMC3294204.

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Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):19943-8. PMID: 22123981; PMCID: PMC3250145.

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Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip. 2011 Dec 21; 11(24):4165-73. PMID: 22072288; PMCID: PMC4038963.

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Alford PW, Nesmith AP, Seywerd JN, Grosberg A, Parker KK. Vascular smooth muscle contractility depends on cell shape. Integr Biol (Camb). 2011 Nov; 3(11):1063-70. PMID: 21993765.

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Grosberg A, Kuo PL, Guo CL, Geisse NA, Bray MA, Adams WJ, Sheehy SP, Parker KK. Self-organization of muscle cell structure and function. PLoS Comput Biol. 2011 Feb; 7(2):e1001088. PMID: 21390276; PMCID: PMC3044763.

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Grosberg A, Gharib M, Kheradvar A. Effect of fiber geometry on pulsatile pumping and energy expenditure. Bull Math Biol. 2009 Oct; 71(7):1580-98. PMID: 19288064.

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Grosberg A, Gharib M. Modeling the macro-structure of the heart: healthy and diseased. Med Biol Eng Comput. 2009 Mar; 47(3):301-11. PMID: 19184159.

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Grosberg A, Gharib M. Computational models of heart pumping efficiencies based on contraction waves in spiral elastic bands. J Theor Biol. 2009 Apr 07; 257(3):359-70. PMID: 19109980.

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