Anna Grosberg

Title(s)	Associate Professor, Biomedical Engineering
School	Samueli School of Engineering
Address	2418 Engineering III Zot 2730 Irvine CA 92697
Phone	(949) 824-3211
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Research

Research Activities and Funding

Functional and mechanistic analysis of FSHD myocytes
NIH R21AR079654Sep 22, 2021 - Aug 31, 2023
Role: Co-Principal Investigator

Quantifying Multi-Scale Architecture of Cardiac Tissues
NIH R03EB028605Jul 20, 2021 - Apr 30, 2023
Role: Principal Investigator

Cardiac Functional and Structural Implications of Lamin A/C Mutations
NIH R01HL129008Sep 4, 2015 - Apr 30, 2021
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Statistical parametrization of cell cytoskeleton reveals lung cancer cytoskeletal phenotype with partial EMT signature. Commun Biol. 2022 05 02; 5(1):407. Basu A, Paul MK, Alioscha-Perez M, Grosberg A, Sahli H, Dubinett SM, Weiss S. PMID: 35501466; PMCID: PMC9061773.

View in: PubMed Mentions: Translation:Humans Cells
An Energetic Approach to Modeling Cytoskeletal Architecture in Maturing Cardiomyocytes. J Biomech Eng. 2022 02 01; 144(2). Sherman WF, Asad M, Grosberg A. PMID: 34382649; PMCID: PMC8547018.

View in: PubMed Mentions: Fields:
Bio Biomedical Engineering
Translation:Cells
Quantitative Evaluation of Cardiac Cell Interactions and Responses to Cyclic Strain. Cells. 2021 11 17; 10(11). Tran RDH, Morris TA, Gonzalez D, Hetta AHSHA, Grosberg A. PMID: 34831422; PMCID: PMC8625419.

View in: PubMed Mentions: Fields:
Bio Biophysics Cel Cell Biology Mol Molecular Biology
Translation:Cells
A Study of Gene Expression, Structure, and Contractility of iPSC-Derived Cardiac Myocytes from a Family with Heart Disease due to LMNA Mutation. Ann Biomed Eng. 2021 Dec; 49(12):3524-3539. Mehrabi M, Morris TA, Cang Z, Nguyen CHH, Sha Y, Asad MN, Khachikyan N, Greene TL, Becker DM, Nie Q, Zaragoza MV, Grosberg A. PMID: 34585335; PMCID: PMC8671287.

View in: PubMed Mentions: 1 Fields:
Bio Biomedical Engineering
Translation:Humans Cells
Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis. BMC Med Genet. 2020 07 22; 21(1):152. Widyastuti HP, Norden-Krichmar TM, Grosberg A, Zaragoza MV. PMID: 32698886; PMCID: PMC7374820.

View in: PubMed Mentions: 4 Fields:
Gen Genetics
Translation:Humans Cells
The Effect of Cyclic Strain on Human Fibroblasts With Lamin A/C Mutations and Its Relation to Heart Disease. J Biomech Eng. 2020 06 01; 142(6). Tran RDH, Siemens M, Nguyen CHH, Ochs AR, Zaragoza MV, Grosberg A. PMID: 31233093; PMCID: PMC7104779.

View in: PubMed Mentions: 2 Fields:
Bio Biomedical Engineering
Translation:Humans Cells
An adapted particle swarm optimization algorithm as a model for exploring premyofibril formation. AIP Adv. 2020 Apr; 10(4):045126. Sherman W, Grosberg A. PMID: 32341885; PMCID: PMC7166122.

View in: PubMed Mentions:
Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs. PLoS Comput Biol. 2020 03; 16(3):e1007676. Morris TA, Naik J, Fibben KS, Kong X, Kiyono T, Yokomori K, Grosberg A. PMID: 32130207; PMCID: PMC7075639.

View in: PubMed Mentions: 9 Fields:
Com Computational Biology
Translation:Humans Animals Cells
Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations. Ann Biomed Eng. 2020 Mar; 48(3):905-912. White JA, Gaver DP, Butera RJ, Choi B, Dunlop MJ, Grande-Allen KJ, Grosberg A, Hitchcock RW, Huang-Saad AY, Kotche M, Kyle AM, Lerner AL, Linehan JH, Linsenmeier RA, Miller MI, Papin JA, Setton L, Sgro A, Smith ML, Zaman M, Lee AP. PMID: 32026231.

View in: PubMed Mentions: 7 Fields:
Bio Biomedical Engineering
Translation:Humans
Exploring cardiac form and function: A length-scale computational biology approach. Wiley Interdiscip Rev Syst Biol Med. 2020 03; 12(2):e1470. Sherman WF, Grosberg A. PMID: 31793215; PMCID: PMC7211030.

View in: PubMed Mentions: 3 Fields:
Com Computational Biology Med Medical Informatics
Translation:Humans Cells
Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering. J Vis Exp. 2019 11 22; (153). Ochs AR, Mehrabi M, Becker D, Asad MN, Zhao J, Zaragoza MV, Grosberg A. PMID: 31814616; PMCID: PMC7156791.

View in: PubMed Mentions: 1 Fields:
Bio Biology Med Medicine (General)
Translation:Humans Cells
A Low-Cost Mechanical Stretching Device for Uniaxial Strain of Cells: A Platform for Pedagogy in Mechanobiology. J Biomech Eng. 2018 08 01; 140(8). Atcha H, Davis CT, Sullivan NR, Smith TD, Anis S, Dahbour WZ, Robinson ZR, Grosberg A, Liu WF. PMID: 30003248; PMCID: PMC6056193.

View in: PubMed Mentions: 6 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations. PLoS One. 2017; 12(11):e0188256. Core JQ, Mehrabi M, Robinson ZR, Ochs AR, McCarthy LA, Zaragoza MV, Grosberg A. PMID: 29149195; PMCID: PMC5693421.

View in: PubMed Mentions: 7 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Dupuytren's and Ledderhose Diseases in a Family with LMNA-Related Cardiomyopathy and a Novel Variant in the ASTE1 Gene. Cells. 2017 Nov 01; 6(4). Zaragoza MV, Nguyen CHH, Widyastuti HP, McCarthy LA, Grosberg A. PMID: 29104234; PMCID: PMC5753070.

View in: PubMed Mentions: 3 Fields:
Bio Biophysics Cel Cell Biology Mol Molecular Biology
Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Exp Biol Med (Maywood). 2017 11; 242(17):1643-1656. Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. PMID: 28343439; PMCID: PMC5786366.

View in: PubMed Mentions: 15 Fields:
Bio Biology Med Medicine (General)Phy Physiology
Translation:Animals Cells
Multiscale Characterization of Engineered Cardiac Tissue Architecture. J Biomech Eng. 2016 11 01; 138(11). Drew NK, Johnsen NE, Core JQ, Grosberg A. PMID: 27617880; PMCID: PMC6993780.

View in: PubMed Mentions: 8 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. PLoS One. 2016; 11(5):e0155421. Zaragoza MV, Fung L, Jensen E, Oh F, Cung K, McCarthy LA, Tran CK, Hoang V, Hakim SA, Grosberg A. PMID: 27182706; PMCID: PMC4868298.

View in: PubMed Mentions: 15 Fields:
Med Medicine (General)Sci Science
Translation:Humans Cells
Emergent Global Contractile Force in Cardiac Tissues. Biophys J. 2016 Apr 12; 110(7):1615-1624. Knight MB, Drew NK, McCarthy LA, Grosberg A. PMID: 27074686; PMCID: PMC4833833.

View in: PubMed Mentions: 10 Fields:
Bio Biophysics
Translation:Animals
Metrics for assessing cytoskeletal orientational correlations and consistency. PLoS Comput Biol. 2015 Apr; 11(4):e1004190. Drew NK, Eagleson MA, Baldo DB, Parker KK, Grosberg A. PMID: 25849553; PMCID: PMC4388480.

View in: PubMed Mentions: 20 Fields:
Com Computational Biology
Translation:Animals Cells
Methods of myofibrillogenesis modeling. Methods Mol Biol. 2015; 1299:75-91. Drew NK, Grosberg A. PMID: 25836576.

View in: PubMed Mentions: 1 Fields:
Mol Molecular Biology
Translation:Animals Cells
Quality metrics for stem cell-derived cardiac myocytes. Stem Cell Reports. 2014 Mar 11; 2(3):282-94. Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK. PMID: 24672752; PMCID: PMC3964283.

View in: PubMed Mentions: 52 Fields:
Cel Cell Biology
Translation:Animals Cells
Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells. Biomaterials. 2014 Jan; 35(2):675-83. Chen A, Lee E, Tu R, Santiago K, Grosberg A, Fowlkes C, Khine M. PMID: 24144905; PMCID: PMC9300448.

View in: PubMed Mentions: 15 Fields:
Bio Biomedical Engineering
Translation:Humans Cells
Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9770-5. McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK. PMID: 23716679; PMCID: PMC3683774.

View in: PubMed Mentions: 65 Fields:
Sci Science
Translation:Humans Animals Cells
A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol. 2012 Aug; 30(8):792-7. Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. PMID: 22820316; PMCID: PMC4026938.

View in: PubMed Mentions: 124 Fields:
Bio Biotechnology
Translation:Animals Cells
The contribution of cellular mechanotransduction to cardiomyocyte form and function. Biomech Model Mechanobiol. 2012 Nov; 11(8):1227-39. Sheehy SP, Grosberg A, Parker KK. PMID: 22772714; PMCID: PMC3786397.

View in: PubMed Mentions: 38 Fields:
Bio Biomedical Engineering
Translation:Humans Animals Cells
Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials. 2012 Aug; 33(23):5732-41. Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK. PMID: 22594976; PMCID: PMC4026933.

View in: PubMed Mentions: 91 Fields:
Bio Biomedical Engineering
Translation:Animals Cells
Muscle on a chip: in vitro contractility assays for smooth and striated muscle. J Pharmacol Toxicol Methods. 2012 May-Jun; 65(3):126-35. Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. PMID: 22521339; PMCID: PMC4184427.

View in: PubMed Mentions: 58 Fields:
Pha Pharmacology Tox Toxicology
Translation:Humans Animals Cells
Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior. J Biomech. 2012 Mar 15; 45(5):832-41. Shim J, Grosberg A, Nawroth JC, Parker KK, Bertoldi K. PMID: 22236531; PMCID: PMC3294204.

View in: PubMed Mentions: 20 Fields:
Phy Physiology
Translation:Animals Cells
Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):19943-8. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. PMID: 22123981; PMCID: PMC3250145.

View in: PubMed Mentions: 69 Fields:
Sci Science
Translation:Animals Cells
Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip. 2011 Dec 21; 11(24):4165-73. Grosberg A, Alford PW, McCain ML, Parker KK. PMID: 22072288; PMCID: PMC4038963.

View in: PubMed Mentions: 187 Fields:
Bio Biotechnology Che Chemistry
Translation:Animals Cells
Vascular smooth muscle contractility depends on cell shape. Integr Biol (Camb). 2011 Nov; 3(11):1063-70. Alford PW, Nesmith AP, Seywerd JN, Grosberg A, Parker KK. PMID: 21993765; PMCID: PMC8388149.

View in: PubMed Mentions: 50 Fields:
Bio Biology
Translation:Humans Cells
Self-organization of muscle cell structure and function. PLoS Comput Biol. 2011 Feb; 7(2):e1001088. Grosberg A, Kuo PL, Guo CL, Geisse NA, Bray MA, Adams WJ, Sheehy SP, Parker KK. PMID: 21390276; PMCID: PMC3044763.

View in: PubMed Mentions: 49 Fields:
Com Computational Biology
Translation:Animals Cells
Effect of fiber geometry on pulsatile pumping and energy expenditure. Bull Math Biol. 2009 Oct; 71(7):1580-98. Grosberg A, Gharib M, Kheradvar A. PMID: 19288064.

View in: PubMed Mentions: 5 Fields:
Bio Biology Sta Statistics as Topic
Translation:Humans Cells
Modeling the macro-structure of the heart: healthy and diseased. Med Biol Eng Comput. 2009 Mar; 47(3):301-11. Grosberg A, Gharib M. PMID: 19184159.

View in: PubMed Mentions: 3 Fields:
Bio Biomedical Engineering Med Medical Informatics
Translation:Humans Cells
Computational models of heart pumping efficiencies based on contraction waves in spiral elastic bands. J Theor Biol. 2009 Apr 07; 257(3):359-70. Grosberg A, Gharib M. PMID: 19109980.

View in: PubMed Mentions: 1 Fields:
Bio Biology
Translation:Humans Animals Cells