Anna Grosberg

Title(s)Associate Professor, Biomedical Engineering
SchoolSamueli School of Engineering
Address2418 Engineering III
Zot 2730
Irvine CA 92697
Phone(949) 824-3211
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    Collapse Research 
    Collapse Research Activities and Funding
    Functional and mechanistic analysis of FSHD myocytes
    NIH R21AR079654Sep 22, 2021 - Aug 31, 2023
    Role: Co-Principal Investigator
    Quantifying Multi-Scale Architecture of Cardiac Tissues
    NIH R03EB028605Jul 20, 2021 - Apr 30, 2023
    Role: Principal Investigator
    Cardiac Functional and Structural Implications of Lamin A/C Mutations
    NIH R01HL129008Sep 4, 2015 - Apr 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Guidelines for Mechanistic Modeling and Analysis in Cardiovascular Research. Am J Physiol Heart Circ Physiol. 2024 Jun 21. Colebank MJ, Oomen PA, Witzenburg CM, Grosberg A, Beard DA, Husmeier D, Olufsen MS, Chesler NC. PMID: 38904851.
      View in: PubMed   Mentions:    Fields:    
    2. LMNA -Related Dilated Cardiomyopathy: Single-Cell Transcriptomics during Patient-derived iPSC Differentiation Support Cell type and Lineage-specific Dysregulation of Gene Expression and Development for Cardiomyocytes and Epicardium-Derived Cells with Lamin A/C Haploinsufficiency. bioRxiv. 2024 Jun 14. Zaragoza MV, Bui TA, Widyastuti HP, Mehrabi M, Cang Z, Sha Y, Grosberg A, Nie Q. PMID: 38915555; PMCID: PMC11195187.
      View in: PubMed   Mentions:
    3. Effect of Porous Substrate Topographies on Cell Dynamics: A Computational Study. ACS Biomater Sci Eng. 2023 Oct 09; 9(10):5666-5678. Gonthier AR, Botvinick EL, Grosberg A, Mohraz A. PMID: 37713253; PMCID: PMC10565724.
      View in: PubMed   Mentions:    Fields:    
    4. A mathematical model to serve as a clinical tool for assessing obstructive sleep apnea severity. Front Physiol. 2023; 14:1198132. Qayyum NT, Wallace CH, Khayat RN, Grosberg A. PMID: 37601632; PMCID: PMC10434550.
      View in: PubMed   Mentions:
    5. CardioStart Online: A Virtual High School Tissue Engineering Course. Biomed Eng Educ. 2023 Mar 20; 1-15. Naik J, Grosberg A, King C. PMID: 37363619; PMCID: PMC10027270.
      View in: PubMed   Mentions:
    6. A comprehensive review of computational and image analysis techniques for quantitative evaluation of striated muscle tissue architecture. Biophys Rev (Melville). 2022 Dec; 3(4):041302. Morris TA, Eldeen S, Tran RDH, Grosberg A. PMID: 36407035; PMCID: PMC9667907.
      View in: PubMed   Mentions: 1  
    7. Statistical parametrization of cell cytoskeleton reveals lung cancer cytoskeletal phenotype with partial EMT signature. Commun Biol. 2022 05 02; 5(1):407. Basu A, Paul MK, Alioscha-Perez M, Grosberg A, Sahli H, Dubinett SM, Weiss S. PMID: 35501466; PMCID: PMC9061773.
      View in: PubMed   Mentions: 6  Translation:HumansCells
    8. An Energetic Approach to Modeling Cytoskeletal Architecture in Maturing Cardiomyocytes. J Biomech Eng. 2022 02 01; 144(2). Sherman WF, Asad M, Grosberg A. PMID: 34382649; PMCID: PMC8547018.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    9. Quantitative Evaluation of Cardiac Cell Interactions and Responses to Cyclic Strain. Cells. 2021 11 17; 10(11). Tran RDH, Morris TA, Gonzalez D, Hetta AHSHA, Grosberg A. PMID: 34831422; PMCID: PMC8625419.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. A Study of Gene Expression, Structure, and Contractility of iPSC-Derived Cardiac Myocytes from a Family with Heart Disease due to LMNA Mutation. Ann Biomed Eng. 2021 Dec; 49(12):3524-3539. Mehrabi M, Morris TA, Cang Z, Nguyen CHH, Sha Y, Asad MN, Khachikyan N, Greene TL, Becker DM, Nie Q, Zaragoza MV, Grosberg A. PMID: 34585335; PMCID: PMC8671287.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis. BMC Med Genet. 2020 07 22; 21(1):152. Widyastuti HP, Norden-Krichmar TM, Grosberg A, Zaragoza MV. PMID: 32698886; PMCID: PMC7374820.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. The Effect of Cyclic Strain on Human Fibroblasts With Lamin A/C Mutations and Its Relation to Heart Disease. J Biomech Eng. 2020 06 01; 142(6). Tran RDH, Siemens M, Nguyen CHH, Ochs AR, Zaragoza MV, Grosberg A. PMID: 31233093; PMCID: PMC7104779.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. An adapted particle swarm optimization algorithm as a model for exploring premyofibril formation. AIP Adv. 2020 Apr; 10(4):045126. Sherman W, Grosberg A. PMID: 32341885; PMCID: PMC7166122.
      View in: PubMed   Mentions:
    14. Striated myocyte structural integrity: Automated analysis of sarcomeric z-discs. PLoS Comput Biol. 2020 03; 16(3):e1007676. Morris TA, Naik J, Fibben KS, Kong X, Kiyono T, Yokomori K, Grosberg A. PMID: 32130207; PMCID: PMC7075639.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    15. Core Competencies for Undergraduates in Bioengineering and Biomedical Engineering: Findings, Consequences, and Recommendations. Ann Biomed Eng. 2020 Mar; 48(3):905-912. White JA, Gaver DP, Butera RJ, Choi B, Dunlop MJ, Grande-Allen KJ, Grosberg A, Hitchcock RW, Huang-Saad AY, Kotche M, Kyle AM, Lerner AL, Linehan JH, Linsenmeier RA, Miller MI, Papin JA, Setton L, Sgro A, Smith ML, Zaman M, Lee AP. PMID: 32026231.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    16. Exploring cardiac form and function: A length-scale computational biology approach. Wiley Interdiscip Rev Syst Biol Med. 2020 03; 12(2):e1470. Sherman WF, Grosberg A. PMID: 31793215; PMCID: PMC7211030.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    17. Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering. J Vis Exp. 2019 11 22; (153). Ochs AR, Mehrabi M, Becker D, Asad MN, Zhao J, Zaragoza MV, Grosberg A. PMID: 31814616; PMCID: PMC7156791.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. A Low-Cost Mechanical Stretching Device for Uniaxial Strain of Cells: A Platform for Pedagogy in Mechanobiology. J Biomech Eng. 2018 08 01; 140(8). Atcha H, Davis CT, Sullivan NR, Smith TD, Anis S, Dahbour WZ, Robinson ZR, Grosberg A, Liu WF. PMID: 30003248; PMCID: PMC6056193.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    19. Age of heart disease presentation and dysmorphic nuclei in patients with LMNA mutations. PLoS One. 2017; 12(11):e0188256. Core JQ, Mehrabi M, Robinson ZR, Ochs AR, McCarthy LA, Zaragoza MV, Grosberg A. PMID: 29149195; PMCID: PMC5693421.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    20. Dupuytren's and Ledderhose Diseases in a Family with LMNA-Related Cardiomyopathy and a Novel Variant in the ASTE1 Gene. Cells. 2017 Nov 01; 6(4). Zaragoza MV, Nguyen CHH, Widyastuti HP, McCarthy LA, Grosberg A. PMID: 29104234; PMCID: PMC5753070.
      View in: PubMed   Mentions: 3     Fields:    
    21. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Exp Biol Med (Maywood). 2017 11; 242(17):1643-1656. Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. PMID: 28343439; PMCID: PMC5786366.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    22. Multiscale Characterization of Engineered Cardiac Tissue Architecture. J Biomech Eng. 2016 11 01; 138(11). Drew NK, Johnsen NE, Core JQ, Grosberg A. PMID: 27617880; PMCID: PMC6993780.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. Exome Sequencing Identifies a Novel LMNA Splice-Site Mutation and Multigenic Heterozygosity of Potential Modifiers in a Family with Sick Sinus Syndrome, Dilated Cardiomyopathy, and Sudden Cardiac Death. PLoS One. 2016; 11(5):e0155421. Zaragoza MV, Fung L, Jensen E, Oh F, Cung K, McCarthy LA, Tran CK, Hoang V, Hakim SA, Grosberg A. PMID: 27182706; PMCID: PMC4868298.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    24. Emergent Global Contractile Force in Cardiac Tissues. Biophys J. 2016 Apr 12; 110(7):1615-1624. Knight MB, Drew NK, McCarthy LA, Grosberg A. PMID: 27074686; PMCID: PMC4833833.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    25. Metrics for assessing cytoskeletal orientational correlations and consistency. PLoS Comput Biol. 2015 Apr; 11(4):e1004190. Drew NK, Eagleson MA, Baldo DB, Parker KK, Grosberg A. PMID: 25849553; PMCID: PMC4388480.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    26. Methods of myofibrillogenesis modeling. Methods Mol Biol. 2015; 1299:75-91. Drew NK, Grosberg A. PMID: 25836576.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Quality metrics for stem cell-derived cardiac myocytes. Stem Cell Reports. 2014 Mar 11; 2(3):282-94. Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK. PMID: 24672752; PMCID: PMC3964283.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    28. Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells. Biomaterials. 2014 Jan; 35(2):675-83. Chen A, Lee E, Tu R, Santiago K, Grosberg A, Fowlkes C, Khine M. PMID: 24144905; PMCID: PMC9300448.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    29. Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9770-5. McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK. PMID: 23716679; PMCID: PMC3683774.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    30. A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol. 2012 Aug; 30(8):792-7. Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. PMID: 22820316; PMCID: PMC4026938.
      View in: PubMed   Mentions: 148     Fields:    Translation:AnimalsCells
    31. The contribution of cellular mechanotransduction to cardiomyocyte form and function. Biomech Model Mechanobiol. 2012 Nov; 11(8):1227-39. Sheehy SP, Grosberg A, Parker KK. PMID: 22772714; PMCID: PMC3786397.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    32. Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials. 2012 Aug; 33(23):5732-41. Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK. PMID: 22594976; PMCID: PMC4026933.
      View in: PubMed   Mentions: 104     Fields:    Translation:AnimalsCells
    33. Muscle on a chip: in vitro contractility assays for smooth and striated muscle. J Pharmacol Toxicol Methods. 2012 May-Jun; 65(3):126-35. Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. PMID: 22521339; PMCID: PMC4184427.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    34. Modeling of cardiac muscle thin films: pre-stretch, passive and active behavior. J Biomech. 2012 Mar 15; 45(5):832-41. Shim J, Grosberg A, Nawroth JC, Parker KK, Bertoldi K. PMID: 22236531; PMCID: PMC3294204.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    35. Cyclic strain induces dual-mode endothelial-mesenchymal transformation of the cardiac valve. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):19943-8. Balachandran K, Alford PW, Wylie-Sears J, Goss JA, Grosberg A, Bischoff J, Aikawa E, Levine RA, Parker KK. PMID: 22123981; PMCID: PMC3250145.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    36. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip. 2011 Dec 21; 11(24):4165-73. Grosberg A, Alford PW, McCain ML, Parker KK. PMID: 22072288; PMCID: PMC4038963.
      View in: PubMed   Mentions: 212     Fields:    Translation:AnimalsCells
    37. Vascular smooth muscle contractility depends on cell shape. Integr Biol (Camb). 2011 Nov; 3(11):1063-70. Alford PW, Nesmith AP, Seywerd JN, Grosberg A, Parker KK. PMID: 21993765; PMCID: PMC8388149.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    38. Self-organization of muscle cell structure and function. PLoS Comput Biol. 2011 Feb; 7(2):e1001088. Grosberg A, Kuo PL, Guo CL, Geisse NA, Bray MA, Adams WJ, Sheehy SP, Parker KK. PMID: 21390276; PMCID: PMC3044763.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    39. Effect of fiber geometry on pulsatile pumping and energy expenditure. Bull Math Biol. 2009 Oct; 71(7):1580-98. Grosberg A, Gharib M, Kheradvar A. PMID: 19288064.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    40. Modeling the macro-structure of the heart: healthy and diseased. Med Biol Eng Comput. 2009 Mar; 47(3):301-11. Grosberg A, Gharib M. PMID: 19184159.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    41. Computational models of heart pumping efficiencies based on contraction waves in spiral elastic bands. J Theor Biol. 2009 Apr 07; 257(3):359-70. Grosberg A, Gharib M. PMID: 19109980.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
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