Selma Masri

Title(s)Assistant Professor, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-3855
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    Collapse Biography 
    Collapse Education and Training
    Beckman Research Institute of the City of HopePh.D.06/2009Cancer Biology
    University of California, IrvinePostdoctoral Training09/2017Circadian Biology and Metabolism
    Collapse Awards and Honors
    V Foundation for Cancer Research2018  - 2020V Scholar Award
    NIH/NCI2017  - 2020K22 Career Development Award

    Collapse Overview 
    Collapse Overview
    Research in the Masri lab is aimed at understanding the relationship between disruption of circadian rhythms and tumorigenesis. We are interested in two research questions. The first question relates to how genetic disruption of the circadian clock in mouse models alters tumorigenesis both at the level of initiation and disease progression. The second question is aimed at elucidating the systemic crosstalk between tumors and peripheral tissues and how cancer cells are able to rewire circadian metabolism at a distance. The Masri lab utilizes genetic mouse models, basic molecular and cell biology, as well as genome-wide ‘omics’ approaches to determine changes in gene expression programs, histone modifications, and alterations in metabolites using metabolomics.

    Collapse Research 
    Collapse Research Activities and Funding
    Circadian Clock Disruption and Colorectal Cancer
    NIH R01CA244519Mar 1, 2020 - Feb 28, 2025
    Role: Principal Investigator
    V Foundation for Cancer Research Nov 1, 2018 - Nov 1, 2020
    Role: PI
    Concern Foundation for Cancer Research Jul 1, 2018 - Jun 30, 2019
    Role: PI
    Tumor Macroenvironment and the Circadian Metabolic Clock
    NIH K22CA212045Dec 1, 2017 - Nov 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. Elife. 2024 Jan 15; 12. Zhou M, Tamburini I, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo R, Bae H, Le J, Larson N, Pulido R, Nascimento-Filho CHV, Jang C, Marazzi I, Justice J, Pannunzio N, Hevener AL, Sparks L, Kershaw EE, Nicholas D, Parker BL, Masri S, Seldin MM. PMID: 38224289; PMCID: PMC10945578.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview. Clin Med Insights Oncol. 2023; 17:11795549231211521. Kaakour D, Fortin B, Masri S, Rezazadeh A. PMID: 38033743; PMCID: PMC10683379.
      View in: PubMed   Mentions:
    3. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. bioRxiv. 2023 Oct 04. Zhou M, Tamburini IJ, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo RX, Bae H, Le J, Larson N, Pulido R, Filho C, Jang C, Marazzi I, Justice JN, Pannunzio N, Hevener A, Sparks LM, Kershaw EE, Nicholas D, Parker B, Masri S, Seldin M. PMID: 37214953; PMCID: PMC10197628.
      View in: PubMed   Mentions:
    4. Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities. Res Sq. 2023 Sep 11. Pannunzio N, Rangel V, Sterrenberg J, Garawi A, Mezcord V, Folkerts M, Caulderon S, Wang J, Soyfer E, Eng O, Valerin J, Tanjasiri S, Quintero-Rivera F, Masri S, Seldin M, Frock R, Fleischman A. PMID: 37790327; PMCID: PMC10543404.
      View in: PubMed   Mentions:
    5. Liver and muscle circadian clocks cooperate to support glucose tolerance in mice. Cell Rep. 2023 06 27; 42(6):112588. Smith JG, Koronowski KB, Mortimer T, Sato T, Greco CM, Petrus P, Verlande A, Chen S, Samad M, Deyneka E, Mathur L, Blazev R, Molendijk J, Kumar A, Deryagin O, Vaca-Dempere M, Sica V, Liu P, Orlando V, Parker BL, Baldi P, Welz PS, Jang C, Masri S, Benitah SA, Muñoz-Cánoves P, Sassone-Corsi P. PMID: 37267101; PMCID: PMC10592114.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    6. Ovol1/2 loss-induced epidermal defects elicit skin immune activation and alter global metabolism. EMBO Rep. 2023 Jul 05; 24(7):e56214. Dragan M, Chen Z, Li Y, Le J, Sun P, Haensel D, Sureshchandra S, Pham A, Lu E, Pham KT, Verlande A, Vu R, Gutierrez G, Li W, Jang C, Masri S, Dai X. PMID: 37249012; PMCID: PMC10328084.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. The circadian control of tryptophan metabolism regulates the host response to pulmonary fungal infections. PNAS Nexus. 2023 Mar; 2(3):pgad036. Stincardini C, Pariano M, D'Onofrio F, Renga G, Orecchini E, Orabona C, Nunzi E, Gargaro M, Fallarino F, Chun SK, Fortin BM, Masri S, Brancorsini S, Romani L, Costantini C, Bellet MM. PMID: 36896128; PMCID: PMC9991457.
      View in: PubMed   Mentions:
    8. Exogenous detection of 13C-glucose metabolism in tumor and diet-induced obesity models. Front Physiol. 2022; 13:1023614. Verlande A, Chun SK, Song WA, Oettler D, Knot HJ, Masri S. PMID: 36277179; PMCID: PMC9581140.
      View in: PubMed   Mentions:
    9. Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer. Sci Adv. 2022 08 12; 8(32):eabo2389. Chun SK, Fortin BM, Fellows RC, Habowski AN, Verlande A, Song WA, Mahieu AL, Lefebvre AEYT, Sterrenberg JN, Velez LM, Digman MA, Edwards RA, Pannunzio NR, Seldin MM, Waterman ML, Masri S. PMID: 35947664; PMCID: PMC9365282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. Circadian Control of Transcriptional and Metabolic Rhythms in Primary Hepatocytes. Methods Mol Biol. 2022; 2482:169-179. Chun SK, Masri S. PMID: 35610426; PMCID: PMC9435321.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms. Sci Adv. 2021 Sep 24; 7(39):eabi7828. Greco CM, Koronowski KB, Smith JG, Shi J, Kunderfranco P, Carriero R, Chen S, Samad M, Welz PS, Zinna VM, Mortimer T, Chun SK, Shimaji K, Sato T, Petrus P, Kumar A, Vaca-Dempere M, Deryagin O, Van C, Kuhn JMM, Lutter D, Seldin MM, Masri S, Li W, Baldi P, Dyar KA, Muñoz-Cánoves P, Benitah SA, Sassone-Corsi P. PMID: 34550736; PMCID: PMC8457671.
      View in: PubMed   Mentions: 27     Fields:    
    12. Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity. EMBO Mol Med. 2021 08 09; 13(8):e13086. Jayashankar V, Selwan E, Hancock SE, Verlande A, Goodson MO, Eckenstein KH, Milinkeviciute G, Hoover BM, Chen B, Fleischman AG, Cramer KS, Hanessian S, Masri S, Turner N, Edinger AL. PMID: 34231322; PMCID: PMC8350895.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    13. Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a model of lung cancer-associated cachexia. Sci Adv. 2021 06; 7(26). Verlande A, Chun SK, Goodson MO, Fortin BM, Bae H, Jang C, Masri S. PMID: 34172439; PMCID: PMC8232919.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    14. Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake. Proc Natl Acad Sci U S A. 2019 12 10; 116(50):25250-25259. Gaucher J, Kinouchi K, Ceglia N, Montellier E, Peleg S, Greco CM, Schmidt A, Forne I, Masri S, Baldi P, Imhof A, Sassone-Corsi P. PMID: 31757851; PMCID: PMC6911183.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    15. Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism. Trends Endocrinol Metab. 2019 07; 30(7):445-458. Verlande A, Masri S. PMID: 31155396; PMCID: PMC6679985.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    16. Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Rep. 2018 12 18; 25(12):3299-3314.e6. Kinouchi K, Magnan C, Ceglia N, Liu Y, Cervantes M, Pastore N, Huynh T, Ballabio A, Baldi P, Masri S, Sassone-Corsi P. PMID: 30566858; PMCID: PMC6433478.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    17. The emerging link between cancer, metabolism, and circadian rhythms. Nat Med. 2018 12; 24(12):1795-1803. Masri S, Sassone-Corsi P. PMID: 30523327; PMCID: PMC6535395.
      View in: PubMed   Mentions: 148     Fields:    Translation:Humans
    18. Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks. Cell. 2018 09 06; 174(6):1571-1585.e11. Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Kinouchi K, Wang C, Swerdloff R, Nadeef S, Masri S, Magistretti P, Orlando V, Borrelli E, Uhlenhaut NH, Baldi P, Adamski J, Tschöp MH, Eckel-Mahan K, Sassone-Corsi P. PMID: 30193114; PMCID: PMC6501776.
      View in: PubMed   Mentions: 128     Fields:    Translation:Animals
    19. Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. Cell. 2017 Aug 10; 170(4):664-677.e11. Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA, Sassone-Corsi P. PMID: 28802039; PMCID: PMC7792549.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    20. Histone Deacetylase SIRT1 Controls Proliferation, Circadian Rhythm, and Lipid Metabolism during Liver Regeneration in Mice. J Biol Chem. 2016 10 28; 291(44):23318-23329. Bellet MM, Masri S, Astarita G, Sassone-Corsi P, Della Fazia MA, Servillo G. PMID: 27634039; PMCID: PMC5087747.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    21. Metabolic demand of the hepatic cell cycle. Cell Cycle. 2016 11 16; 15(22):3020-3021. Masri S. PMID: 27485093; PMCID: PMC5134694.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Cell. 2016 May 05; 165(4):896-909. Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P. PMID: 27153497; PMCID: PMC5373476.
      View in: PubMed   Mentions: 114     Fields:    Translation:AnimalsCells
    23. Sirtuin-dependent clock control: new advances in metabolism, aging and cancer. Curr Opin Clin Nutr Metab Care. 2015 Nov; 18(6):521-7. Masri S. PMID: 26335311; PMCID: PMC4610809.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    24. Coupling circadian rhythms of metabolism and chromatin remodelling. Diabetes Obes Metab. 2015 Sep; 17 Suppl 1:17-22. Masri S, Orozco-Solis R, Aguilar-Arnal L, Cervantes M, Sassone-Corsi P. PMID: 26332964; PMCID: PMC4732882.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    25. Circadian clocks, epigenetics, and cancer. Curr Opin Oncol. 2015 Jan; 27(1):50-6. Masri S, Kinouchi K, Sassone-Corsi P. PMID: 25405464; PMCID: PMC4732884.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    26. Sirtuins and the circadian clock: bridging chromatin and metabolism. Sci Signal. 2014 Sep 09; 7(342):re6. Masri S, Sassone-Corsi P. PMID: 25205852.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    27. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014 Jul 31; 158(3):659-72. Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. PMID: 25083875; PMCID: PMC5472354.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    28. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. J Biol Chem. 2014 Feb 28; 289(9):6091-7. Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. PMID: 24425865; PMCID: PMC3937675.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    29. The circadian clock and cell cycle: interconnected biological circuits. Curr Opin Cell Biol. 2013 Dec; 25(6):730-4. Masri S, Cervantes M, Sassone-Corsi P. PMID: 23969329; PMCID: PMC4573394.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    30. Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3339-44. Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P. PMID: 23341599; PMCID: PMC3587221.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    31. The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci. 2013 01; 14(1):69-75. Masri S, Sassone-Corsi P. PMID: 23187814; PMCID: PMC5720680.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    32. The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control. Ann N Y Acad Sci. 2012 Aug; 1264:103-9. Masri S, Zocchi L, Katada S, Mora E, Sassone-Corsi P. PMID: 22834651; PMCID: PMC3464365.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    33. SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol. 2011 Jan; 25(1):72-82. Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S. PMID: 21084382; PMCID: PMC3089033.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    34. Plasticity and specificity of the circadian epigenome. Nat Neurosci. 2010 Nov; 13(11):1324-9. Masri S, Sassone-Corsi P. PMID: 20975756; PMCID: PMC4071955.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    35. The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells. Breast Cancer Res Treat. 2010 Nov; 124(1):89-99. Masri S, Liu Z, Phung S, Wang E, Yuan YC, Chen S. PMID: 20054641; PMCID: PMC3295576.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    36. Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines. J Steroid Biochem Mol Biol. 2010 Feb 28; 118(4-5):277-82. Masri S, Phung S, Wang X, Chen S. PMID: 19897035; PMCID: PMC2836255.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    37. Progress in aromatase research and identification of key future directions. J Steroid Biochem Mol Biol. 2010 Feb 28; 118(4-5):311-5. Dunbier AK, Hong Y, Masri S, Brown KA, Sabnis GJ, Palomares MR. PMID: 19778609.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug; 116(3):461-70. Masri S, Lui K, Phung S, Ye J, Zhou D, Wang X, Chen S. PMID: 18677558; PMCID: PMC3503449.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    39. Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer Res. 2008 Jun 15; 68(12):4910-8. Masri S, Phung S, Wang X, Wu X, Yuan YC, Wagman L, Chen S. PMID: 18559539.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
    40. The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop. Cancer Res. 2008 Apr 01; 68(7):2259-65. Wang X, Masri S, Phung S, Chen S. PMID: 18381432; PMCID: PMC2735892.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    41. New experimental models for aromatase inhibitor resistance. J Steroid Biochem Mol Biol. 2007 Aug-Sep; 106(1-5):8-15. Chen S, Masri S, Hong Y, Wang X, Phung S, Yuan YC, Wu X. PMID: 17611102; PMCID: PMC2743954.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    42. What do we know about the mechanisms of aromatase inhibitor resistance? J Steroid Biochem Mol Biol. 2006 Dec; 102(1-5):232-40. Chen S, Masri S, Wang X, Phung S, Yuan YC, Wu X. PMID: 17055257; PMCID: PMC1829446.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    43. Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res. 2006; 34(17):4791-800. Rosen LE, Morrison HA, Masri S, Brown MJ, Springstubb B, Sussman D, Stoddard BL, Seligman LM. PMID: 16971456; PMCID: PMC1635285.
      View in: PubMed   Mentions: 42     Fields:    
    44. Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1. Gene. 2005 Nov 21; 361:89-100. Zhou D, Masri S, Ye JJ, Chen S. PMID: 16181749.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    45. Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene which encodes the viral cell attachment protein sigma 1. Nucleic Acids Res. 1984 Nov 26; 12(22):8699-710. Nagata L, Masri SA, Mah DC, Lee PW. PMID: 6095208; PMCID: PMC320408.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
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