Masri, Selma

Title(s)Assistant Professor, Biological Chemistry
Phone(949) 824-3855
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    Collapse Biography 
    Collapse Education and Training
    Beckman Research Institute of the City of HopePh.D.06/2009Cancer Biology
    University of California, IrvinePostdoctoral Training09/2017Circadian Biology and Metabolism
    Collapse Awards and Honors
    V Foundation for Cancer Research2018  - 2020V Scholar Award
    NIH/NCI2017  - 2020K22 Career Development Award

    Collapse Overview 
    Collapse Overview
    Research in the Masri lab is aimed at understanding the relationship between disruption of circadian rhythms and tumorigenesis. We are interested in two research questions. The first question relates to how genetic disruption of the circadian clock in mouse models alters tumorigenesis both at the level of initiation and disease progression. The second question is aimed at elucidating the systemic crosstalk between tumors and peripheral tissues and how cancer cells are able to rewire circadian metabolism at a distance. The Masri lab utilizes genetic mouse models, basic molecular and cell biology, as well as genome-wide ‘omics’ approaches to determine changes in gene expression programs, histone modifications, and alterations in metabolites using metabolomics.

    Collapse Research 
    Collapse Research Activities and Funding
    V Foundation for Cancer Research Nov 1, 2018 - Nov 1, 2020
    Role: PI
    Concern Foundation for Cancer Research Jul 1, 2018 - Jun 30, 2019
    Role: PI
    Tumor Macroenvironment and the Circadian Metabolic Clock
    NIH/NCI K22CA212045Dec 1, 2017 - Nov 30, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kinouchi K, Magnan C, Ceglia N, Liu Y, Cervantes M, Pastore N, Huynh T, Ballabio A, Baldi P, Masri S, Sassone-Corsi P. Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Rep. 2018 Dec 18; 25(12):3299-3314.e6. PMID: 30566858.
      View in: PubMed
    2. Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Kinouchi K, Wang C, Swerdloff R, Nadeef S, Masri S, Magistretti P, Orlando V, Borrelli E, Uhlenhaut NH, Baldi P, Adamski J, Tschöp MH, Eckel-Mahan K, Sassone-Corsi P. Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks. Cell. 2018 Sep 06; 174(6):1571-1585.e11. PMID: 30193114.
      View in: PubMed
    3. Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA, Sassone-Corsi P. Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. Cell. 2017 Aug 10; 170(4):664-677.e11. PMID: 28802039.
      View in: PubMed
    4. Bellet MM, Masri S, Astarita G, Sassone-Corsi P, Della Fazia MA, Servillo G. Histone Deacetylase SIRT1 Controls Proliferation, Circadian Rhythm, and Lipid Metabolism during Liver Regeneration in Mice. J Biol Chem. 2016 10 28; 291(44):23318-23329. PMID: 27634039.
      View in: PubMed
    5. Masri S. Metabolic demand of the hepatic cell cycle. Cell Cycle. 2016 11 16; 15(22):3020-3021. PMID: 27485093.
      View in: PubMed
    6. Masri S, Papagiannakopoulos T, Kinouchi K, Liu Y, Cervantes M, Baldi P, Jacks T, Sassone-Corsi P. Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis. Cell. 2016 May 05; 165(4):896-909. PMID: 27153497.
      View in: PubMed
    7. Masri S. Sirtuin-dependent clock control: new advances in metabolism, aging and cancer. Curr Opin Clin Nutr Metab Care. 2015 Nov; 18(6):521-7. PMID: 26335311; PMCID: PMC4610809 [Available on 11/01/16].
    8. Masri S, Orozco-Solis R, Aguilar-Arnal L, Cervantes M, Sassone-Corsi P. Coupling circadian rhythms of metabolism and chromatin remodelling. Diabetes Obes Metab. 2015 Sep; 17 Suppl 1:17-22. PMID: 26332964; PMCID: PMC4732882.
    9. Masri S, Kinouchi K, Sassone-Corsi P. Circadian clocks, epigenetics, and cancer. Curr Opin Oncol. 2015 Jan; 27(1):50-6. PMID: 25405464; PMCID: PMC4732884.
    10. Masri S, Sassone-Corsi P. Sirtuins and the circadian clock: bridging chromatin and metabolism. Sci Signal. 2014 Sep 09; 7(342):re6. PMID: 25205852.
      View in: PubMed
    11. Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell. 2014 Jul 31; 158(3):659-72. PMID: 25083875.
      View in: PubMed
    12. Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. J Biol Chem. 2014 Feb 28; 289(9):6091-7. PMID: 24425865; PMCID: PMC3937675.
    13. Masri S, Cervantes M, Sassone-Corsi P. The circadian clock and cell cycle: interconnected biological circuits. Curr Opin Cell Biol. 2013 Dec; 25(6):730-4. PMID: 23969329; PMCID: PMC4573394.
    14. Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P. Circadian acetylome reveals regulation of mitochondrial metabolic pathways. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3339-44. PMID: 23341599; PMCID: PMC3587221.
    15. Masri S, Sassone-Corsi P. The circadian clock: a framework linking metabolism, epigenetics and neuronal function. Nat Rev Neurosci. 2013 01; 14(1):69-75. PMID: 23187814.
      View in: PubMed
    16. Masri S, Zocchi L, Katada S, Mora E, Sassone-Corsi P. The circadian clock transcriptional complex: metabolic feedback intersects with epigenetic control. Ann N Y Acad Sci. 2012 Aug; 1264:103-9. PMID: 22834651; PMCID: PMC3464365.
    17. Wang Y, Zhou D, Phung S, Masri S, Smith D, Chen S. SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells. Mol Endocrinol. 2011 Jan; 25(1):72-82. PMID: 21084382; PMCID: PMC3089033.
    18. Masri S, Sassone-Corsi P. Plasticity and specificity of the circadian epigenome. Nat Neurosci. 2010 Nov; 13(11):1324-9. PMID: 20975756; PMCID: PMC4071955.
    19. Masri S, Liu Z, Phung S, Wang E, Yuan YC, Chen S. The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells. Breast Cancer Res Treat. 2010 Nov; 124(1):89-99. PMID: 20054641; PMCID: PMC3295576.
    20. Masri S, Phung S, Wang X, Chen S. Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines. J Steroid Biochem Mol Biol. 2010 Feb 28; 118(4-5):277-82. PMID: 19897035; PMCID: PMC2836255.
    21. Dunbier AK, Hong Y, Masri S, Brown KA, Sabnis GJ, Palomares MR. Progress in aromatase research and identification of key future directions. J Steroid Biochem Mol Biol. 2010 Feb 28; 118(4-5):311-5. PMID: 19778609.
      View in: PubMed
    22. Masri S, Lui K, Phung S, Ye J, Zhou D, Wang X, Chen S. Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug; 116(3):461-70. PMID: 18677558; PMCID: PMC3503449.
    23. Masri S, Phung S, Wang X, Wu X, Yuan YC, Wagman L, Chen S. Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer Res. 2008 Jun 15; 68(12):4910-8. PMID: 18559539.
      View in: PubMed
    24. Wang X, Masri S, Phung S, Chen S. The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop. Cancer Res. 2008 Apr 01; 68(7):2259-65. PMID: 18381432; PMCID: PMC2735892.
    25. Chen S, Masri S, Hong Y, Wang X, Phung S, Yuan YC, Wu X. New experimental models for aromatase inhibitor resistance. J Steroid Biochem Mol Biol. 2007 Aug-Sep; 106(1-5):8-15. PMID: 17611102; PMCID: PMC2743954.
    26. Chen S, Masri S, Wang X, Phung S, Yuan YC, Wu X. What do we know about the mechanisms of aromatase inhibitor resistance? J Steroid Biochem Mol Biol. 2006 Dec; 102(1-5):232-40. PMID: 17055257; PMCID: PMC1829446.
    27. Rosen LE, Morrison HA, Masri S, Brown MJ, Springstubb B, Sussman D, Stoddard BL, Seligman LM. Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res. 2006; 34(17):4791-800. PMID: 16971456.
      View in: PubMed
    28. Zhou D, Masri S, Ye JJ, Chen S. Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1. Gene. 2005 Nov 21; 361:89-100. PMID: 16181749.
      View in: PubMed