Ivan Marazzi

Title(s)Professor, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
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    1. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 06; 606(7916):945-952. Campisi L, Chizari S, Ho JSY, Gromova A, Arnold FJ, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. PMID: 35732742.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR. Nat Biotechnol. 2022 11; 40(11):1680-1689. Schwarz M, Torre D, Lozano-Ojalvo D, Tan AT, Tabaglio T, Mzoughi S, Sanchez-Tarjuelo R, Le Bert N, Lim JME, Hatem S, Tuballes K, Camara C, Lopez-Granados E, Paz-Artal E, Correa-Rocha R, Ortiz A, Lopez-Hoyos M, Portoles J, Cervera I, Gonzalez-Perez M, Bodega-Mayor I, Conde P, Oteo-Iglesias J, Borobia AM, Carcas AJ, Frías J, Belda-Iniesta C, Ho JSY, Nunez K, Hekmaty S, Mohammed K, Marsiglia WM, Carreño JM, Dar AC, Berin C, Nicoletti G, Della Noce I, Colombo L, Lapucci C, Santoro G, Ferrari M, Nie K, Patel M, Barcessat V, Gnjatic S, Harris J, Sebra R, Merad M, Krammer F, Kim-Schulze S, Marazzi I, Bertoletti A, Ochando J, Guccione E. PMID: 35697804.
      View in: PubMed   Mentions:    Fields:    
    3. Emergency drug use in a pandemic: Harsh lessons from COVID-19. Cell. 2021 10 28; 184(22):5497-5500. Cross G, Ho JSY, Zacharias W, Jeyasekharan AD, Marazzi I. PMID: 34587491; PMCID: PMC8452505.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    4. A small nucleosome from a weird virus with a fat genome. Mol Cell. 2021 09 02; 81(17):3447-3448. Vannini A, Marazzi I. PMID: 34478653.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness. Elife. 2021 06 02; 10. Ho JS, Di Tullio F, Schwarz M, Low D, Incarnato D, Gay F, Tabaglio T, Zhang J, Wollmann H, Chen L, An O, Chan THM, Hall Hickman A, Zheng S, Roudko V, Chen S, Karz A, Ahmed M, He HH, Greenbaum BD, Oliviero S, Serresi M, Gargiulo G, Mann KM, Hernando E, Mulholland D, Marazzi I, Wee DKB, Guccione E. PMID: 34075878; PMCID: PMC8346284.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    6. Unconventional viral gene expression mechanisms as therapeutic targets. Nature. 2021 05; 593(7859):362-371. Ho JSY, Zhu Z, Marazzi I. PMID: 34012080.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells. J Exp Med. 2021 07 05; 218(7). Lim JY, Duttke SH, Baker TS, Lee J, Gambino KJ, Venturini NJ, Ho JSY, Zheng S, Fstkchyan YS, Pillai V, Fajgenbaum DC, Marazzi I, Benner C, Byun M. PMID: 33970190; PMCID: PMC8111463.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell. 2021 05 13; 184(10):2618-2632.e17. Ho JSY, Mok BW, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Zhang AJ, Lee AC, Liu WC, Jangra S, Escalera A, Aydillo T, Melo BS, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Miraldi ER, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I. PMID: 33836156; PMCID: PMC8008343.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    9. Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models. bioRxiv. 2020 Dec 01. Yuin Ho JS, Wing-Yee Mok B, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Junxia Zhang A, Chak-Yiu Lee A, Liu WC, Aydillo T, Salom Melo B, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Miraldi ER, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I. PMID: 33299999; PMCID: PMC7724667.
      View in: PubMed   Mentions:
    10. Human Virus Transcriptional Regulators. Cell. 2020 07 09; 182(1):24-37. Liu X, Hong T, Parameswaran S, Ernst K, Marazzi I, Weirauch MT, Fuxman Bass JI. PMID: 32649876; PMCID: PMC7346790.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    11. Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection. Cell. 2020 06 25; 181(7):1502-1517.e23. Ho JSY, Angel M, Ma Y, Sloan E, Wang G, Martinez-Romero C, Alenquer M, Roudko V, Chung L, Zheng S, Chang M, Fstkchyan Y, Clohisey S, Dinan AM, Gibbs J, Gifford R, Shen R, Gu Q, Irigoyen N, Campisi L, Huang C, Zhao N, Jones JD, van Knippenberg I, Zhu Z, Moshkina N, Meyer L, Noel J, Peralta Z, Rezelj V, Kaake R, Rosenberg B, Wang B, Wei J, Paessler S, Wise HM, Johnson J, Vannini A, Amorim MJ, Baillie JK, Miraldi ER, Benner C, Brierley I, Digard P, Luksza M, Firth AE, Krogan N, Greenbaum BD, MacLeod MK, van Bakel H, Garcìa-Sastre A, Yewdell JW, Hutchinson E, Marazzi I. PMID: 32559462; PMCID: PMC7323901.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    12. A Quantitative Genetic Interaction Map of HIV Infection. Mol Cell. 2020 04 16; 78(2):197-209.e7. Gordon DE, Watson A, Roguev A, Zheng S, Jang GM, Kane J, Xu J, Guo JZ, Stevenson E, Swaney DL, Franks-Skiba K, Verschueren E, Shales M, Crosby DC, Frankel AD, Marson A, Marazzi I, Cagney G, Krogan NJ. PMID: 32084337; PMCID: PMC7462049.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    13. Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Cell. 2018 12 13; 175(7):1931-1945.e18. Shah PS, Link N, Jang GM, Sharp PP, Zhu T, Swaney DL, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit MJ, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias GN, Shokat L, Tripathi S, Balasubramaniam V, Webb LG, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard KS, Cherry S, Gamarnik AV, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen HJ, Andino R, Krogan NJ. PMID: 30550790; PMCID: PMC6474419.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    14. Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. Immunity. 2018 11 20; 49(5):819-828.e6. Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J. PMID: 30413362; PMCID: PMC6251711.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    15. Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol. 2018 09; 25(9):885-893. Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I. PMID: 30177761.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    16. Transcription Elongation Can Affect Genome 3D Structure. Cell. 2018 09 06; 174(6):1522-1536.e22. Heinz S, Texari L, Hayes MGB, Urbanowski M, Chang MW, Givarkes N, Rialdi A, White KM, Albrecht RA, Pache L, Marazzi I, García-Sastre A, Shaw ML, Benner C. PMID: 30146161; PMCID: PMC6130916.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    17. Chromatin dependencies in cancer and inflammation. Nat Rev Mol Cell Biol. 2018 04; 19(4):245-261. Marazzi I, Greenbaum BD, Low DHP, Guccione E. PMID: 29184195.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    18. The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity. Cell. 2017 05 04; 169(4):679-692.e14. Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang ZZ, Laffleur B, Kaake RM, McGregor MJ, Haas K, Pefanis E, Albrecht RA, Pache L, Chanda S, Jen J, Ochando J, Byun M, Basu U, García-Sastre A, Krogan N, van Bakel H, Marazzi I. PMID: 28475896; PMCID: PMC6217988.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    19. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 2016 May 27; 352(6289):aad7993. Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JSY, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. PMID: 27127234; PMCID: PMC5193222.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    20. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. 2016 Jan 19; 44(1):46-58. Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. PMID: 26789921; PMCID: PMC4878455.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    21. Interference of viral effector proteins with chromatin, transcription, and the epigenome. Curr Opin Microbiol. 2015 Aug; 26:123-9. Marazzi I, Garcia-Sastre A. PMID: 26232586.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    22. Editorial overview: host-microbe interactions: viruses. Curr Opin Microbiol. 2015 Aug; 26:v-vi. Marazzi I, García-Sastre A. PMID: 26205286.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    23. Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. Nat Immunol. 2015 May; 16(5):485-94. Miller MS, Rialdi A, Ho JS, Tilove M, Martinez-Gil L, Moshkina NP, Peralta Z, Noel J, Melegari C, Maestre AM, Mitsopoulos P, Madrenas J, Heinz S, Benner C, Young JA, Feagins AR, Basler CF, Fernandez-Sesma A, Becherel OJ, Lavin MF, van Bakel H, Marazzi I. PMID: 25822250; PMCID: PMC4406851.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. Suppression of the antiviral response by an influenza histone mimic. Nature. 2012 Mar 14; 483(7390):428-33. Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A. PMID: 22419161; PMCID: PMC3598589.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansCells
    25. Suppression of inflammation by a synthetic histone mimic. Nature. 2010 Dec 23; 468(7327):1119-23. Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A. PMID: 21068722; PMCID: PMC5415086.
      View in: PubMed   Mentions: 671     Fields:    Translation:AnimalsCells
    26. Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell. 2007 Aug 17; 27(4):596-608. Sampath SC, Marazzi I, Yap KL, Sampath SC, Krutchinsky AN, Mecklenbräuker I, Viale A, Rudensky E, Zhou MM, Chait BT, Tarakhovsky A. PMID: 17707231.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    27. A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity. EMBO J. 2006 Feb 22; 25(4):798-810. Bosisio D, Marazzi I, Agresti A, Shimizu N, Bianchi ME, Natoli G. PMID: 16467852; PMCID: PMC1383558.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    28. Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time. Nat Immunol. 2005 May; 6(5):439-45. Natoli G, Saccani S, Bosisio D, Marazzi I. PMID: 15843800.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    29. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J Exp Med. 2004 Jul 05; 200(1):107-13. Saccani S, Marazzi I, Beg AA, Natoli G. PMID: 15226358; PMCID: PMC2213320.
      View in: PubMed   Mentions: 116     Fields:    Translation:HumansAnimalsCells
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