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Kong, Mei

Title(s)Associate Professor, Molecular Biology & Biochemistry
Phone(949) 824-5244
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    Collapse Research 
    Collapse Research Activities and Funding
    Protein Phosphatase Control of AMPK Function
    NIH/NIGMS R01GM132142Apr 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Cancer Cell Adaption to Glutamine Deprivation
    NIH/NCI R01CA183989Sep 1, 2014 - Apr 30, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Cell Rep. 2019 Mar 12; 26(11):3051-3060.e4. PMID: 30865893.
      View in: PubMed
    2. Yang Y, Ishak Gabra MB, Hanse EA, Lowman XH, Tran TQ, Li H, Milman N, Liu J, Reid MA, Locasale JW, Gil Z, Kong M. MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nat Commun. 2019 02 18; 10(1):809. PMID: 30778058.
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    3. Bian C, Zhang C, Luo T, Vyas A, Chen SH, Liu C, Kassab MA, Yang Y, Kong M, Yu X. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nat Commun. 2019 02 11; 10(1):693. PMID: 30741937.
      View in: PubMed
    4. Ishak Gabra MB, Yang Y, Lowman XH, Reid MA, Tran TQ, Kong M. IKKß activates p53 to promote cancer cell adaptation to glutamine deprivation. Oncogenesis. 2018 Nov 26; 7(11):93. PMID: 30478303.
      View in: PubMed
    5. Abeywardana T, Oh M, Jiang L, Yang Y, Kong M, Song J, Yang Y. CARM1 suppresses de novo serine synthesis by promoting PKM2 activity. J Biol Chem. 2018 09 28; 293(39):15290-15303. PMID: 30131339.
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    6. Tran TQ, Ishak Gabra MB, Lowman XH, Yang Y, Reid MA, Pan M, O'Connor TR, Kong M. Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes. PLoS Biol. 2017 Nov; 15(11):e2002810. PMID: 29107960.
      View in: PubMed
    7. Tran TQ, Lowman XH, Kong M. Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4004-4009. PMID: 28404599.
      View in: PubMed
    8. Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nat Cell Biol. 2016 10; 18(10):1090-101. PMID: 27617932.
      View in: PubMed
    9. Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Mol Aspects Med. 2017 04; 54:50-57. PMID: 27620316.
      View in: PubMed
    10. Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. IKKß promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016 08 15; 30(16):1837-51. PMID: 27585591.
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    11. Rosales KR, Reid MA, Yang Y, Tran TQ, Wang WI, Lowman X, Pan M, Kong M. TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. PLoS One. 2015; 10(12):e0145938. PMID: 26717153.
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    12. Hernandez-Davies JE, Tran TQ, Reid MA, Rosales KR, Lowman XH, Pan M, Moriceau G, Yang Y, Wu J, Lo RS, Kong M. Vemurafenib resistance reprograms melanoma cells towards glutamine dependence. J Transl Med. 2015 Jul 03; 13:210. PMID: 26139106.
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    13. Fong MY, Zhou W, Liu L, Alontaga AY, Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR, Somlo G, Palomares M, Li Z, Tremblay JR, Tsuyada A, Sun G, Reid MA, Wu X, Swiderski P, Ren X, Shi Y, Kong M, Zhong W, Chen Y, Wang SE. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015 Feb; 17(2):183-94. PMID: 25621950.
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    14. Reid MA, Kong M. Dealing with hunger: Metabolic stress responses in tumors. J Carcinog. 2013 Sep 30; 12:17. PMID: 24227992.
      View in: PubMed
    15. Reid MA, Kong M. Adaptation to metabolic stress: insights into a paradoxical Q. Cell Cycle. 2013 Jun 15; 12(12):1807-8. PMID: 23708515.
      View in: PubMed
    16. Reid MA, Wang WI, Rosales KR, Welliver MX, Pan M, Kong M. The B55a subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Mol Cell. 2013 Apr 25; 50(2):200-11. PMID: 23499005.
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    17. Jiang L, Stanevich V, Satyshur KA, Kong M, Watkins GR, Wadzinski BE, Sengupta R, Xing Y. Structural basis of protein phosphatase 2A stable latency. Nat Commun. 2013; 4:1699. PMID: 23591866.
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    18. Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, Lin LI, Ann DK. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 2012 Oct; 8(10):1477-93. PMID: 22906967.
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    19. Jin X, Chen YP, Kong M, Zheng L, Yang YD, Li YM. Transition from hepatic steatosis to steatohepatitis: unique microRNA patterns and potential downstream functions and pathways. J Gastroenterol Hepatol. 2012 Feb; 27(2):331-40. PMID: 21793903.
      View in: PubMed
    20. Xu J, Mao ZG, Kong M, Hu LH, Ye CY, Xu CG, Rong S, Sun LJ, Wu J, Dai B, Chen DP, Zhu YX, Zhang YX, Zhang YQ, Zhao XZ, Mei CL. Scientific publications in nephrology and urology journals from Chinese authors in East Asia: a 10-year survey of the literature. PLoS One. 2011 Apr 08; 6(4):e14781. PMID: 21494662.
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    21. Kong M, Ditsworth D, Lindsten T, Thompson CB. Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell. 2009 Oct 09; 36(1):51-60. PMID: 19818709.
      View in: PubMed
    22. Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 2005 Jan 28; 120(2):237-48. PMID: 15680329.
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    23. Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB. The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science. 2004 Oct 22; 306(5696):695-8. PMID: 15499020.
      View in: PubMed
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