Mei Kong

Title(s)Associate Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address3219 McGaugh Hall
Zot
Irvine CA 92697
Phone(949) 824-5244
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    Collapse Research 
    Collapse Research Activities and Funding
    Using dietary glutamine supplementation for melanoma prevention and targeted therapy
    NIH R01CA244360Jul 1, 2021 - Jun 30, 2026
    Role: Principal Investigator
    Protein Phosphatase Control of AMPK Function
    NIH R01GM132142Apr 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Cancer Cell Adaption to Glutamine Deprivation
    NIH R01CA183989Sep 1, 2014 - Apr 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An emerging link between lncRNAs and cancer sex dimorphism. Hum Genet. 2023 Dec 14. Naciri I, Andrade-Ludena MD, Yang Y, Kong M, Sun S. PMID: 38095719.
      View in: PubMed   Mentions:    Fields:    
    2. Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia. Genes (Basel). 2023 09 19; 14(9). Ruiz BI, Lowman XH, Yang Y, Fan Q, Wang T, Wu H, Hanse EA, Kong M. PMID: 37761958; PMCID: PMC10531467.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Vitamin B6 is governed by the local compartmentalization of metabolic enzymes during growth. Sci Adv. 2023 09 08; 9(36):eadi2232. Franco CN, Seabrook LJ, Nguyen ST, Yang Y, Campos M, Fan Q, Cicchetto AC, Kong M, Christofk HR, Albrecht LV. PMID: 37682999; PMCID: PMC10491294.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Correlation between Polyphenol Contents and Antioxidant Activities in Different Echinacea Purpurea Varieties. Curr Med Sci. 2023 Aug; 43(4):831-837. Lin XJ, Lai ZS, Luo Q, Kong M, Liang MJ, Wu H, Bai M. PMID: 37480412.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    5. A Novel Assessment of Metabolic Pathways in Peritoneal Metastases from Low-Grade Appendiceal Mucinous Neoplasms. Ann Surg Oncol. 2023 Aug; 30(8):5132-5141. Hanse EA, Wang T, Tifrea D, Senthil M, Kim AC, Kong M, Eng OS. PMID: 37149550.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice. Nat Commun. 2023 03 13; 14(1):1368. Yang Y, Reid MA, Hanse EA, Li H, Li Y, Ruiz BI, Fan Q, Kong M. PMID: 36914647; PMCID: PMC10011557.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    7. Protein interactions network of goat innate immune signalling pathway proteins and Haemonchus contortus excretory-secretory proteins. Parasite Immunol. 2022 12; 44(12):e12950. Wang W, Xie T, Jiang F, Jiang Y, Jin Z, Yang Z, Kong M, Cheng L, Fu L, Du X. PMID: 36104299.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. A happy cell stays home: When metabolic stress creates epigenetic advantages in the tumor microenvironment. Front Oncol. 2022; 12:962928. Hanse EA, Kong M. PMID: 36091163; PMCID: PMC9459228.
      View in: PubMed   Mentions: 2  
    9. Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA Sequencing. Clin Transl Med. 2022 02; 12(2):e730. Jiang H, Yu D, Yang P, Guo R, Kong M, Gao Y, Yu X, Lu X, Fan X. PMID: 35184420; PMCID: PMC8858624.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    10. The B56α subunit of PP2A is necessary for mesenchymal stem cell commitment to adipocyte. EMBO Rep. 2021 08 04; 22(8):e51910. Hanse EA, Pan M, Liu W, Yang Y, Ishak Gabra MB, Tran TQ, Lowman XH, Ruiz B, Wang QA, Kong M. PMID: 34232566; PMCID: PMC8339711.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth. Nat Commun. 2020 07 03; 11(1):3326. Ishak Gabra MB, Yang Y, Li H, Senapati P, Hanse EA, Lowman XH, Tran TQ, Zhang L, Doan LT, Xu X, Schones DE, Fruman DA, Kong M. PMID: 32620791; PMCID: PMC7335172.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    12. α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer. Nat Cancer. 2020 03; 1(3):345-358. Tran TQ, Hanse EA, Habowski AN, Li H, Ishak Gabra MB, Yang Y, Lowman XH, Ooi AM, Liao SY, Edwards RA, Waterman ML, Kong M. PMID: 32832918; PMCID: PMC7442208.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    13. Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing. Nat Cell Biol. 2020 03; 22(3):310-320. Davis RT, Blake K, Ma D, Gabra MBI, Hernandez GA, Phung AT, Yang Y, Maurer D, Lefebvre AEYT, Alshetaiwi H, Xiao Z, Liu J, Locasale JW, Digman MA, Mjolsness E, Kong M, Werb Z, Lawson DA. PMID: 32144411.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    14. p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Cell Rep. 2019 03 12; 26(11):3051-3060.e4. Lowman XH, Hanse EA, Yang Y, Ishak Gabra MB, Tran TQ, Li H, Kong M. PMID: 30865893; PMCID: PMC6510239.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    15. MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1. Nat Commun. 2019 02 18; 10(1):809. Yang Y, Ishak Gabra MB, Hanse EA, Lowman XH, Tran TQ, Li H, Milman N, Liu J, Reid MA, Locasale JW, Gil Z, Kong M. PMID: 30778058; PMCID: PMC6379428.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    16. NADP+ is an endogenous PARP inhibitor in DNA damage response and tumor suppression. Nat Commun. 2019 02 11; 10(1):693. Bian C, Zhang C, Luo T, Vyas A, Chen SH, Liu C, Kassab MA, Yang Y, Kong M, Yu X. PMID: 30741937; PMCID: PMC6370829.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    17. IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation. Oncogenesis. 2018 Nov 26; 7(11):93. Ishak Gabra MB, Yang Y, Lowman XH, Reid MA, Tran TQ, Kong M. PMID: 30478303; PMCID: PMC6255781.
      View in: PubMed   Mentions: 17  
    18. CARM1 suppresses de novo serine synthesis by promoting PKM2 activity. J Biol Chem. 2018 09 28; 293(39):15290-15303. Abeywardana T, Oh M, Jiang L, Yang Y, Kong M, Song J, Yang Y. PMID: 30131339; PMCID: PMC6166735.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    19. Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes. PLoS Biol. 2017 Nov; 15(11):e2002810. Tran TQ, Ishak Gabra MB, Lowman XH, Yang Y, Reid MA, Pan M, O'Connor TR, Kong M. PMID: 29107960; PMCID: PMC5673162.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    20. Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4004-4009. Tran TQ, Lowman XH, Kong M. PMID: 28404599; PMCID: PMC5553983.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    21. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nat Cell Biol. 2016 10; 18(10):1090-101. Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M. PMID: 27617932; PMCID: PMC5536113.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    22. Metabolic interactions with cancer epigenetics. Mol Aspects Med. 2017 04; 54:50-57. Gao X, Reid MA, Kong M, Locasale JW. PMID: 27620316; PMCID: PMC5344790.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    23. IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016 08 15; 30(16):1837-51. Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. PMID: 27585591; PMCID: PMC5024682.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    24. TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. PLoS One. 2015; 10(12):e0145938. Rosales KR, Reid MA, Yang Y, Tran TQ, Wang WI, Lowman X, Pan M, Kong M. PMID: 26717153; PMCID: PMC4696667.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    25. Vemurafenib resistance reprograms melanoma cells towards glutamine dependence. J Transl Med. 2015 Jul 03; 13:210. Hernandez-Davies JE, Tran TQ, Reid MA, Rosales KR, Lowman XH, Pan M, Moriceau G, Yang Y, Wu J, Lo RS, Kong M. PMID: 26139106; PMCID: PMC4490757.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    26. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015 Feb; 17(2):183-94. Fong MY, Zhou W, Liu L, Alontaga AY, Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR, Somlo G, Palomares M, Li Z, Tremblay JR, Tsuyada A, Sun G, Reid MA, Wu X, Swiderski P, Ren X, Shi Y, Kong M, Zhong W, Chen Y, Wang SE. PMID: 25621950; PMCID: PMC4380143.
      View in: PubMed   Mentions: 570     Fields:    Translation:HumansCells
    27. Dealing with hunger: Metabolic stress responses in tumors. J Carcinog. 2013 Sep 30; 12:17. Reid MA, Kong M. PMID: 24227992; PMCID: PMC3816312.
      View in: PubMed   Mentions: 18  
    28. Adaptation to metabolic stress: insights into a paradoxical Q. Cell Cycle. 2013 Jun 15; 12(12):1807-8. Reid MA, Kong M. PMID: 23708515; PMCID: PMC3735684.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    29. The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Mol Cell. 2013 Apr 25; 50(2):200-11. Reid MA, Wang WI, Rosales KR, Welliver MX, Pan M, Kong M. PMID: 23499005.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    30. Structural basis of protein phosphatase 2A stable latency. Nat Commun. 2013; 4:1699. Jiang L, Stanevich V, Satyshur KA, Kong M, Watkins GR, Wadzinski BE, Sengupta R, Xing Y. PMID: 23591866; PMCID: PMC3644067.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    31. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 2012 Oct; 8(10):1477-93. Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, Lin LI, Ann DK. PMID: 22906967; PMCID: PMC3679231.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    32. Transition from hepatic steatosis to steatohepatitis: unique microRNA patterns and potential downstream functions and pathways. J Gastroenterol Hepatol. 2012 Feb; 27(2):331-40. Jin X, Chen YP, Kong M, Zheng L, Yang YD, Li YM. PMID: 21793903.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    33. Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell. 2009 Oct 09; 36(1):51-60. Kong M, Ditsworth D, Lindsten T, Thompson CB. PMID: 19818709; PMCID: PMC2761955.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    34. The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration. J Biol Chem. 2007 Oct 05; 282(40):29712-20. Kong M, Bui TV, Ditsworth D, Gruber JJ, Goncharov D, Krymskaya VP, Lindsten T, Thompson CB. PMID: 17693407.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    35. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell. 2005 Jan 28; 120(2):237-48. Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB. PMID: 15680329.
      View in: PubMed   Mentions: 635     Fields:    Translation:AnimalsCells
    36. The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science. 2004 Oct 22; 306(5696):695-8. Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB. PMID: 15499020.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
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