Kong, Mei

Title(s)Associate Professor, Molecular Biology & Biochemistry
Phone(949) 824-5244
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    Cancer cell adaptation to glutamine deprivation
    NIH/NCI R01CA183989Sep 1, 2014 - Apr 30, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ishak Gabra MB, Yang Y, Lowman XH, Reid MA, Tran TQ, Kong M. IKKß activates p53 to promote cancer cell adaptation to glutamine deprivation. Oncogenesis. 2018 Nov 26; 7(11):93. PMID: 30478303.
      View in: PubMed
    2. Abeywardana T, Oh M, Jiang L, Yang Y, Kong M, Song J, Yang Y. CARM1 suppresses de novo serine synthesis by promoting PKM2 activity. J Biol Chem. 2018 Sep 28; 293(39):15290-15303. PMID: 30131339.
      View in: PubMed
    3. Tran TQ, Ishak Gabra MB, Lowman XH, Yang Y, Reid MA, Pan M, O'Connor TR, Kong M. Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes. PLoS Biol. 2017 Nov; 15(11):e2002810. PMID: 29107960.
      View in: PubMed
    4. Tran TQ, Lowman XH, Kong M. Molecular Pathways: Metabolic Control of Histone Methylation and Gene Expression in Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4004-4009. PMID: 28404599.
      View in: PubMed
    5. Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M. Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation. Nat Cell Biol. 2016 10; 18(10):1090-101. PMID: 27617932.
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    6. Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Mol Aspects Med. 2017 04; 54:50-57. PMID: 27620316.
      View in: PubMed
    7. Reid MA, Lowman XH, Pan M, Tran TQ, Warmoes MO, Ishak Gabra MB, Yang Y, Locasale JW, Kong M. IKKß promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. Genes Dev. 2016 08 15; 30(16):1837-51. PMID: 27585591.
      View in: PubMed
    8. Rosales KR, Reid MA, Yang Y, Tran TQ, Wang WI, Lowman X, Pan M, Kong M. TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. PLoS One. 2015; 10(12):e0145938. PMID: 26717153.
      View in: PubMed
    9. Hernandez-Davies JE, Tran TQ, Reid MA, Rosales KR, Lowman XH, Pan M, Moriceau G, Yang Y, Wu J, Lo RS, Kong M. Vemurafenib resistance reprograms melanoma cells towards glutamine dependence. J Transl Med. 2015 Jul 03; 13:210. PMID: 26139106; PMCID: PMC4490757.
    10. Fong MY, Zhou W, Liu L, Alontaga AY, Chandra M, Ashby J, Chow A, O'Connor ST, Li S, Chin AR, Somlo G, Palomares M, Li Z, Tremblay JR, Tsuyada A, Sun G, Reid MA, Wu X, Swiderski P, Ren X, Shi Y, Kong M, Zhong W, Chen Y, Wang SE. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015 Feb; 17(2):183-94. PMID: 25621950.
      View in: PubMed
    11. Reid MA, Kong M. Dealing with hunger: Metabolic stress responses in tumors. J Carcinog. 2013 Sep 30; 12:17. PMID: 24227992; PMCID: PMC3816312.
    12. Reid MA, Wang WI, Rosales KR, Welliver MX, Pan M, Kong M. The B55a subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Mol Cell. 2013 Apr 25; 50(2):200-11. PMID: 23499005.
      View in: PubMed
    13. Jin X, Chen YP, Kong M, Zheng L, Yang YD, Li YM. Transition from hepatic steatosis to steatohepatitis: unique microRNA patterns and potential downstream functions and pathways. J Gastroenterol Hepatol. 2012 Feb; 27(2):331-40. PMID: 21793903.
      View in: PubMed
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