Minji Byun

Title(s)Assistant Professor, Microbiology and Molecular Genetics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
ORCID ORCID Icon0000-0002-2830-4079 Additional info
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    POSTECH, Pohang, South KoreaB.S.02/2002Life Sciences
    Washington University in St. Louis, St. Louis, MOPhD05/2009Immunology
    Rockefeller University, New York, NYPostdoctoral08/2014Human Genetics

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    My group is interested in understanding the impact of genetic variants on the function of immune cells and on predisposition to pathologies driven by the immune system. In particular, we are interested in studying defects of the DNA methylation pathway in the context of aging-associated clonal hematopoiesis. Acquired mutations in DNMT3A (a writer of DNA methylation) and TET2 (an eraser of DNA methylation) are common in the hematopoietic stem cells of elderly individuals, estimated to affect more than 10% of adults over the age of 65. These mutations increase the risk for various age-related comorbidities such as atherosclerosis, thereby nearly doubling the mortality rate of affected individuals. We hypothesize that these mutations impair DNA methylation remodeling that occurs during the differentiation of hematopoietic stem cells, leading to altered gene expression and function of terminally differentiated immune effector cells such as macrophages. We use various cutting-edge human genetic and epigenetic tools and experimental model systems such as human pluripotent stem cell-derived macrophages to address our questions.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation. Mol Cell. 2023 Dec 07; 83(23):4255-4271.e9. Torre D, Fstkchyan YS, Ho JSY, Cheon Y, Patel RS, Degrace EJ, Mzoughi S, Schwarz M, Mohammed K, Seo JS, Romero-Bueno R, Demircioglu D, Hasson D, Tang W, Mahajani SU, Campisi L, Zheng S, Song WS, Wang YC, Shah H, Francoeur N, Soto J, Salfati Z, Weirauch MT, Warburton P, Beaumont K, Smith ML, Mulder L, Villalta SA, Kessenbrock K, Jang C, Lee D, De Rubeis S, Cobos I, Tam O, Hammell MG, Seldin M, Shi Y, Basu U, Sebastiano V, Byun M, Sebra R, Rosenberg BR, Benner C, Guccione E, Marazzi I. PMID: 37995687; PMCID: PMC10842741.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4. Nature. 2022 06; 606(7916):945-952. Campisi L, Chizari S, Ho JSY, Gromova A, Arnold FJ, Mosca L, Mei X, Fstkchyan Y, Torre D, Beharry C, Garcia-Forn M, Jiménez-Alcázar M, Korobeynikov VA, Prazich J, Fayad ZA, Seldin MM, De Rubeis S, Bennett CL, Ostrow LW, Lunetta C, Squatrito M, Byun M, Shneider NA, Jiang N, La Spada AR, Marazzi I. PMID: 35732742; PMCID: PMC10089623.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    3. Convergence of cytokine dysregulation and antibody deficiency in common variable immunodeficiency with inflammatory complications. J Allergy Clin Immunol. 2022 01; 149(1):315-326.e9. Abyazi ML, Bell KA, Gyimesi G, Baker TS, Byun M, Ko HM, Cunningham-Rundles C, Feng F, Maglione PJ. PMID: 34146579; PMCID: PMC8678401.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    4. Acute and chronic effects of vaping electronic devices on lung physiology and inflammation. Curr Opin Physiol. 2021 Aug; 22. Masso-Silva JA, Byun MK, Alexander LEC. PMID: 38550798; PMCID: PMC10978006.
      View in: PubMed   Mentions:
    5. DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells. J Exp Med. 2021 07 05; 218(7). Lim JY, Duttke SH, Baker TS, Lee J, Gambino KJ, Venturini NJ, Ho JSY, Zheng S, Fstkchyan YS, Pillai V, Fajgenbaum DC, Marazzi I, Benner C, Byun M. PMID: 33970190; PMCID: PMC8111463.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    6. TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation. Cell. 2021 05 13; 184(10):2618-2632.e17. Ho JSY, Mok BW, Campisi L, Jordan T, Yildiz S, Parameswaran S, Wayman JA, Gaudreault NN, Meekins DA, Indran SV, Morozov I, Trujillo JD, Fstkchyan YS, Rathnasinghe R, Zhu Z, Zheng S, Zhao N, White K, Ray-Jones H, Malysheva V, Thiecke MJ, Lau SY, Liu H, Zhang AJ, Lee AC, Liu WC, Jangra S, Escalera A, Aydillo T, Melo BS, Guccione E, Sebra R, Shum E, Bakker J, Kaufman DA, Moreira AL, Carossino M, Balasuriya UBR, Byun M, Albrecht RA, Schotsaert M, Garcia-Sastre A, Chanda SK, Miraldi ER, Jeyasekharan AD, TenOever BR, Spivakov M, Weirauch MT, Heinz S, Chen H, Benner C, Richt JA, Marazzi I. PMID: 33836156; PMCID: PMC8008343.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    7. A novel FAS mutation with variable expressivity in a family with unicentric and idiopathic multicentric Castleman disease. Blood Adv. 2018 11 13; 2(21):2959-2963. Baker TS, Gambino KJ, Schriefer L, Lim JY, Steinberg KM, Fajgenbaum DC, Martín García-Sancho A, Byun M. PMID: 30404775; PMCID: PMC6234382.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    8. Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol. 2018 09; 25(9):885-893. Zhao N, Sebastiano V, Moshkina N, Mena N, Hultquist J, Jimenez-Morales D, Ma Y, Rialdi A, Albrecht R, Fenouil R, Sánchez-Aparicio MT, Ayllon J, Ravisankar S, Haddad B, Ho JSY, Low D, Jin J, Yurchenko V, Prinjha RK, Tarakhovsky A, Squatrito M, Pinto D, Allette K, Byun M, Smith ML, Sebra R, Guccione E, Tumpey T, Krogan N, Greenbaum B, van Bakel H, García-Sastre A, Marazzi I. PMID: 30177761; PMCID: PMC10754036.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    9. Disseminated Cutaneous Warts in X-Linked Hyper IgM Syndrome. J Clin Immunol. 2018 05; 38(4):454-456. Ho HE, Byun M, Cunningham-Rundles C. PMID: 29730845; PMCID: PMC6030472.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity. Cell. 2017 05 04; 169(4):679-692.e14. Rialdi A, Hultquist J, Jimenez-Morales D, Peralta Z, Campisi L, Fenouil R, Moshkina N, Wang ZZ, Laffleur B, Kaake RM, McGregor MJ, Haas K, Pefanis E, Albrecht RA, Pache L, Chanda S, Jen J, Ochando J, Byun M, Basu U, García-Sastre A, Krogan N, van Bakel H, Marazzi I. PMID: 28475896; PMCID: PMC6217988.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    11. Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis. J Am Coll Cardiol. 2017 Apr 04; 69(13):1653-1665. Belkaya S, Kontorovich AR, Byun M, Mulero-Navarro S, Bajolle F, Cobat A, Josowitz R, Itan Y, Quint R, Lorenzo L, Boucherit S, Stoven C, Di Filippo S, Abel L, Zhang SY, Bonnet D, Gelb BD, Casanova JL. PMID: 28359509; PMCID: PMC5551973.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    12. Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma. J Infect Dis. 2015 Jun 01; 211(11):1842-51. Aavikko M, Kaasinen E, Nieminen JK, Byun M, Donner I, Mancuso R, Ferrante P, Clerici M, Brambilla L, Tourlaki A, Sarid R, Guttman-Yassky E, Taipale M, Morgunova E, Pekkonen P, Ojala PM, Pukkala E, Casanova JL, Vaarala O, Vahteristo P, Aaltonen LA. PMID: 25492914.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    13. TLR3 deficiency in herpes simplex encephalitis: high allelic heterogeneity and recurrence risk. Neurology. 2014 Nov 18; 83(21):1888-97. Lim HK, Seppänen M, Hautala T, Ciancanelli MJ, Itan Y, Lafaille FG, Dell W, Lorenzo L, Byun M, Pauwels E, Rönnelid Y, Cai X, Boucherit S, Jouanguy E, Paetau A, Lebon P, Rozenberg F, Tardieu M, Abel L, Yildiran A, Vergison A, Roivainen R, Etzioni A, Tienari PJ, Casanova JL, Zhang SY. PMID: 25339207; PMCID: PMC4248460.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    14. Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood. J Exp Med. 2013 Aug 26; 210(9):1743-59. Byun M, Ma CS, Akçay A, Pedergnana V, Palendira U, Myoung J, Avery DT, Liu Y, Abhyankar A, Lorenzo L, Schmidt M, Lim HK, Cassar O, Migaud M, Rozenberg F, Canpolat N, Aydogan G, Fleckenstein B, Bustamante J, Picard C, Gessain A, Jouanguy E, Cesarman E, Olivier M, Gros P, Abel L, Croft M, Tangye SG, Casanova JL. PMID: 23897980; PMCID: PMC3754857.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    15. Ribosomal protein SA haploinsufficiency in humans with isolated congenital asplenia. Science. 2013 May 24; 340(6135):976-8. Bolze A, Mahlaoui N, Byun M, Turner B, Trede N, Ellis SR, Abhyankar A, Itan Y, Patin E, Brebner S, Sackstein P, Puel A, Picard C, Abel L, Quintana-Murci L, Faust SN, Williams AP, Baretto R, Duddridge M, Kini U, Pollard AJ, Gaud C, Frange P, Orbach D, Emile JF, Stephan JL, Sorensen R, Plebani A, Hammarstrom L, Conley ME, Selleri L, Casanova JL. PMID: 23579497; PMCID: PMC3677541.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    16. Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science. 2012 Sep 28; 337(6102):1684-8. Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL. PMID: 22859821; PMCID: PMC3507439.
      View in: PubMed   Mentions: 261     Fields:    Translation:HumansAnimalsCells
    17. A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection. Eur J Hum Genet. 2012 Jun; 20(6):690-5. Pedergnana V, Gessain A, Tortevoye P, Byun M, Bacq-Daian D, Boland A, Casanova JL, Abel L, Plancoulaine S. PMID: 22258534; PMCID: PMC3355257.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    18. A mild form of SLC29A3 disorder: a frameshift deletion leads to the paradoxical translation of an otherwise noncoding mRNA splice variant. PLoS One. 2012; 7(1):e29708. Bolze A, Abhyankar A, Grant AV, Patel B, Yadav R, Byun M, Caillez D, Emile JF, Pastor-Anglada M, Abel L, Puel A, Govindarajan R, de Pontual L, Casanova JL. PMID: 22238637; PMCID: PMC3251605.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    19. Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review. Pediatrics. 2012 Jan; 129(1):e199-203. Leroy S, Moshous D, Cassar O, Reguerre Y, Byun M, Pedergnana V, Canioni D, Gessain A, Oksenhendler E, Fieschi C, Mahlaoui N, Rivière JP, Herbigneaux RM, Muszlak M, Arnaud JP, Fischer A, Picard C, Blanche S, Plancoulaine S, Casanova JL. PMID: 22157133; PMCID: PMC3273364.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    20. Whole-exome-sequencing-based discovery of human FADD deficiency. Am J Hum Genet. 2010 Dec 10; 87(6):873-81. Bolze A, Byun M, McDonald D, Morgan NV, Abhyankar A, Premkumar L, Puel A, Bacon CM, Rieux-Laucat F, Pang K, Britland A, Abel L, Cant A, Maher ER, Riedl SJ, Hambleton S, Casanova JL. PMID: 21109225; PMCID: PMC2997374.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    21. Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. J Exp Med. 2010 Oct 25; 207(11):2307-12. Byun M, Abhyankar A, Lelarge V, Plancoulaine S, Palanduz A, Telhan L, Boisson B, Picard C, Dewell S, Zhao C, Jouanguy E, Feske S, Abel L, Casanova JL. PMID: 20876309; PMCID: PMC2964585.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansCells
    22. Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells. Cell Host Microbe. 2009 Nov 19; 6(5):422-32. Byun M, Verweij MC, Pickup DJ, Wiertz EJ, Hansen TH, Yokoyama WM. PMID: 19917497; PMCID: PMC2791900.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    23. Cowpox virus exploits the endoplasmic reticulum retention pathway to inhibit MHC class I transport to the cell surface. Cell Host Microbe. 2007 Nov 15; 2(5):306-15. Byun M, Wang X, Pak M, Hansen TH, Yokoyama WM. PMID: 18005752.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    24. Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster. Nat Immunol. 2003 Aug; 4(8):787-93. Kim MS, Byun M, Oh BH. PMID: 12845326.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
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