Christopher James Halbrook

Title(s)Assistant Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
AddressZot 3900
Irvine CA 92697
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    Collapse Research 
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    Disrupting macrophage metabolism to reduce immunosuppression and enhance therapy in pancreatic cancer
    NIH R00CA241357Sep 30, 2020 - Aug 31, 2023
    Role: Principal Investigator
    Disrupting macrophage metabolism to reduce immunosuppression and enhance therapy in pancreatic cancer
    NIH K99CA241357Apr 1, 2020 - Sep 29, 2020
    Role: Principal Investigator
    Targeting Epithelial-Immune Cell Crosstalk to Improve Therapy in Pancreatic Cancer
    NIH F32CA228328May 1, 2018 - Jul 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cancer Hallmarks: Piecing the Puzzle Together. Cancer Discov. 2024 Apr 04; 14(4):674-682. Alcolea MP, Alonso-Curbelo D, Ambrogio C, Bullman S, Correia AL, Ernst A, Halbrook CJ, Kelly GL, Lund AW, Quail DF, Ruscetti M, Shema E, Stromnes IM, Tam WL. PMID: 38571410.
      View in: PubMed   Mentions:    Fields:    
    2. Glucose-6-phosphate dehydrogenase deficiency accelerates pancreatic acinar-to-ductal metaplasia. bioRxiv. 2023 Nov 08. Radyk MD, Nelson BS, Halbrook CJ, Wood A, Lavoie B, Salvatore L, Corfas G, Colacino JA, Shah YM, Crawford HC, Lyssiotis CA. PMID: 37986898; PMCID: PMC10659312.
      View in: PubMed   Mentions:
    3. Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature. 2023 Jun; 618(7963):151-158. Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee HJ, Dzierozynski LN, He X, Ps H, Ugras J, Nyamundanda G, Zhang L, Halbrook CJ, Carpenter ES, Shi J, Shriver LP, Patti GJ, Muir A, Pasca di Magliano M, Sadanandam A, Lyssiotis CA. PMID: 37198494; PMCID: PMC10232363.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    4. Pancreatic cancer: Advances and challenges. Cell. 2023 04 13; 186(8):1729-1754. Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A. PMID: 37059070; PMCID: PMC10182830.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    5. Arginase 1 is a key driver of immune suppression in pancreatic cancer. Elife. 2023 02 02; 12. Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, Carpenter E, Zhang Y, Halbrook CJ, Lyssiotis CA, Pasca di Magliano M. PMID: 36727849; PMCID: PMC10260021.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    6. Barriers and opportunities for gemcitabine in pancreatic cancer therapy. Am J Physiol Cell Physiol. 2023 02 01; 324(2):C540-C552. Beutel AK, Halbrook CJ. PMID: 36571444; PMCID: PMC9925166.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    7. Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells. Nat Cancer. 2022 11; 3(11):1386-1403. Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. PMID: 36411320; PMCID: PMC9701142.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    8. An Optimized Enzyme-Nucleobase Pair Enables In Vivo RNA Metabolic Labeling with Improved Cell-Specificity. Biochemistry. 2022 12 06; 61(23):2638-2642. Singha MK, Zimak J, Levine SR, Dai N, Hong C, Anaraki C, Gupta M, Halbrook CJ, Atwood SX, Spitale RC. PMID: 36383486; PMCID: PMC10149115.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    9. Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context. Elife. 2022 07 11; 11. Kerk SA, Lin L, Myers AL, Sutton DJ, Andren A, Sajjakulnukit P, Zhang L, Zhang Y, Jiménez JA, Nelson BS, Chen B, Robinson A, Thurston G, Kemp SB, Steele NG, Hoffman MT, Wen HJ, Long D, Ackenhusen SE, Ramos J, Gao X, Nwosu ZC, Galban S, Halbrook CJ, Lombard DB, Piwnica-Worms DR, Ying H, Pasca di Magliano M, Crawford HC, Shah YM, Lyssiotis CA. PMID: 35815941; PMCID: PMC9328765.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    10. Multiomic characterization of pancreatic cancer-associated macrophage polarization reveals deregulated metabolic programs driven by the GM-CSF-PI3K pathway. Elife. 2022 02 14; 11. Boyer S, Lee HJ, Steele N, Zhang L, Sajjakulnukit P, Andren A, Ward MH, Singh R, Basrur V, Zhang Y, Nesvizhskii AI, Pasca di Magliano M, Halbrook CJ, Lyssiotis CA. PMID: 35156921; PMCID: PMC8843093.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    11. Hyaluronic acid fuels pancreatic cancer cell growth. Elife. 2021 12 24; 10. Kim PK, Halbrook CJ, Kerk SA, Radyk M, Wisner S, Kremer DM, Sajjakulnukit P, Andren A, Hou SW, Trivedi A, Thurston G, Anand A, Yan L, Salamanca-Cardona L, Welling SD, Zhang L, Pratt MR, Keshari KR, Ying H, Lyssiotis CA. PMID: 34951587; PMCID: PMC8730721.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    12. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. Nat Commun. 2021 08 11; 12(1):4860. Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. PMID: 34381026; PMCID: PMC8357841.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    13. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth. Cell Metab. 2021 05 04; 33(5):1013-1026.e6. Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. PMID: 33609439; PMCID: PMC8102379.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    14. Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clin Cancer Res. 2021 04 01; 27(7):2023-2037. Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu L, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, Irizarry-Negron V, Halbrook CJ, Franks NE, Hoffman MT, Brown K, Carpenter ES, Nwosu ZC, Johnson C, Lima F, Anderson MA, Park Y, Crawford HC, Lyssiotis CA, Frankel TL, Rao A, Bednar F, Dlugosz AA, Preall JB, Tuveson DA, Allen BL, Pasca di Magliano M. PMID: 33495315; PMCID: PMC8026631.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    15. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020 07 30; 11(1):3811. Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, Umemura Y, Walker AK, Kachman M, Sarkaria JN, Xiong J, Morgan MA, Rehemtualla A, Castro MG, Lowenstein P, Chandrasekaran S, Lawrence TS, Lyssiotis CA, Wahl DR. PMID: 32732914; PMCID: PMC7393131.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    16. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science. 2020 04 03; 368(6486):54-60. Zhou Z, Torres M, Sha H, Halbrook CJ, Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter AH, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, Lyssiotis CA, Wu J, Kersten S, Beard DA, Qi L. PMID: 32193362; PMCID: PMC7409365.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    17. Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis. Cancer Discov. 2020 03; 10(3):422-439. Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai VR, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, Frankel TL, Bednar F, Pasca di Magliano M. PMID: 31911451; PMCID: PMC7224338.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    18. Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy. Cancer Metab. 2020; 8:1. Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, Mashadova O, Nicolay BN, Tolstyka ZP, Halbrook CJ, Chandrasekaran S, Asara JM, Crawford HC, Cantley LC, Kimmelman AC, Wahl DR, Lyssiotis CA. PMID: 31908776; PMCID: PMC6941320.
      View in: PubMed   Mentions: 13  
    19. Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice. Gastroenterology. 2020 04; 158(5):1417-1432.e11. Perusina Lanfranca M, Zhang Y, Girgis A, Kasselman S, Lazarus J, Kryczek I, Delrosario L, Rhim A, Koneva L, Sartor M, Sun L, Halbrook C, Nathan H, Shi J, Crawford HC, Pasca di Magliano M, Zou W, Frankel TL. PMID: 31843590; PMCID: PMC7197347.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    20. Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. Biochemistry. 2020 09 01; 59(34):3169-3179. Walter LA, Lin YH, Halbrook CJ, Chuh KN, He L, Pedowitz NJ, Batt AR, Brennan CK, Stiles BL, Lyssiotis CA, Pratt MR. PMID: 31625393; PMCID: PMC7231633.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    21. Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer. Trends Biochem Sci. 2019 12; 44(12):991-993. Halbrook CJ, Wahl DR, Lyssiotis CA. PMID: 31699584.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Hiding in plain sight. Science. 2019 06 21; 364(6446):1132-1133. Halbrook CJ, Crawford HC. PMID: 31221844; PMCID: PMC6709523.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    23. ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis. Genes Dev. 2019 06 01; 33(11-12):641-655. Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM. PMID: 31048544; PMCID: PMC6546061.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    24. Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors. Cancer Discov. 2019 03; 9(3):326-328. Halbrook CJ, Nelson BS, Lysstiotis CA. PMID: 30824487.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metab. 2019 06 04; 29(6):1390-1399.e6. Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA. PMID: 30827862; PMCID: PMC6602533.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    26. Metabolism and epigenetics of pancreatic cancer stem cells. Semin Cancer Biol. 2019 08; 57:19-26. Perusina Lanfranca M, Thompson JK, Bednar F, Halbrook C, Lyssiotis C, Levi B, Frankel TL. PMID: 30273655; PMCID: PMC6438777.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    27. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. J Pathol. 2018 07; 245(3):324-336. Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER. PMID: 29672864; PMCID: PMC6388767.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    28. Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation. Trends Endocrinol Metab. 2018 09; 29(9):599-602. Halbrook CJ, Nwosu ZC, Lyssiotis CA. PMID: 29692332.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    29. Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2018 07 01; 315(1):G27-G35. Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. PMID: 29543507; PMCID: PMC6109710.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    30. Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. JCI Insight. 2018 01 25; 3(2). Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Cali Daylan AE, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, Lyssiotis CA, Ljungman M, Morton JP, Galbán S, Fearon ER, Pasca di Magliano M. PMID: 29367463; PMCID: PMC5821189.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    31. Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol. 2018; 5(2):169-185.e2. Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M. PMID: 29693047; PMCID: PMC5904051.
      View in: PubMed   Mentions: 8     Fields:    
    32. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. Cancer Cell. 2017 01 09; 31(1):5-19. Halbrook CJ, Lyssiotis CA. PMID: 28073003.
      View in: PubMed   Mentions: 168     Fields:    Translation:Humans
    33. Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):99-118. Halbrook CJ, Wen HJ, Ruggeri JM, Takeuchi KK, Zhang Y, di Magliano MP, Crawford HC. PMID: 28090569; PMCID: PMC5235341.
      View in: PubMed   Mentions: 31     Fields:    
    34. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes Dev. 2016 12 15; 30(24):2669-2683. Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC. PMID: 28087712; PMCID: PMC5238727.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    35. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016 12 01; 540(7631):150. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. PMID: 27706144.
      View in: PubMed   Mentions: 11     Fields:    
    36. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016 08 25; 536(7617):479-83. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. PMID: 27509858; PMCID: PMC5228623.
      View in: PubMed   Mentions: 496     Fields:    Translation:HumansAnimalsCells
    37. PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. Gastroenterology. 2014 Dec; 147(6):1405-16.e7. Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC. PMID: 25311989; PMCID: PMC4252806.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    38. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology. 2014 Jan; 146(1):233-44.e5. Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. PMID: 23999170; PMCID: PMC3870045.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    39. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell. 2012 Sep 11; 22(3):304-17. Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT. PMID: 22975374; PMCID: PMC3443395.
      View in: PubMed   Mentions: 288     Fields:    Translation:HumansAnimalsCells
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