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Christopher James Halbrook

Title(s)Assistant Professor, Molecular Biology & Biochemistry
AddressZot 3900
Irvine CA 92697
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    Collapse Research 
    Collapse Research Activities and Funding
    Disrupting macrophage metabolism to reduce immunosuppression and enhance therapy in pancreatic cancer
    NIH/NCI K99CA241357Apr 1, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Targeting Epithelial-Immune Cell Crosstalk to Improve Therapy in Pancreatic Cancer
    NIH/NCI F32CA228328May 1, 2018 - Jul 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Purine metabolism regulates DNA repair and therapy resistance in glioblastoma. Nat Commun. 2020 07 30; 11(1):3811. Zhou W, Yao Y, Scott AJ, Wilder-Romans K, Dresser JJ, Werner CK, Sun H, Pratt D, Sajjakulnukit P, Zhao SG, Davis M, Nelson BS, Halbrook CJ, Zhang L, Gatto F, Umemura Y, Walker AK, Kachman M, Sarkaria JN, Xiong J, Morgan MA, Rehemtualla A, Castro MG, Lowenstein P, Chandrasekaran S, Lawrence TS, Lyssiotis CA, Wahl DR. PMID: 32732914.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes. Science. 2020 04 03; 368(6486):54-60. Zhou Z, Torres M, Sha H, Halbrook CJ, Van den Bergh F, Reinert RB, Yamada T, Wang S, Luo Y, Hunter AH, Wang C, Sanderson TH, Liu M, Taylor A, Sesaki H, Lyssiotis CA, Wu J, Kersten S, Beard DA, Qi L. PMID: 32193362.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    3. Regulatory T-cell Depletion Alters the Tumor Microenvironment and Accelerates Pancreatic Carcinogenesis. Cancer Discov. 2020 03; 10(3):422-439. Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai VR, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, Frankel TL, Bednar F, Pasca di Magliano M. PMID: 31911451.
      View in: PubMed   Mentions: 6     Fields:    
    4. Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy. Cancer Metab. 2020; 8:1. Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, Mashadova O, Nicolay BN, Tolstyka ZP, Halbrook CJ, Chandrasekaran S, Asara JM, Crawford HC, Cantley LC, Kimmelman AC, Wahl DR, Lyssiotis CA. PMID: 31908776.
      View in: PubMed   Mentions:
    5. Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice. Gastroenterology. 2020 04; 158(5):1417-1432.e11. Perusina Lanfranca M, Zhang Y, Girgis A, Kasselman S, Lazarus J, Kryczek I, Delrosario L, Rhim A, Koneva L, Sartor M, Sun L, Halbrook C, Nathan H, Shi J, Crawford HC, Pasca di Magliano M, Zou W, Frankel TL. PMID: 31843590.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress. Biochemistry. 2020 Sep 01; 59(34):3169-3179. Walter LA, Lin YH, Halbrook CJ, Chuh KN, He L, Pedowitz NJ, Batt AR, Brennan CK, Stiles BL, Lyssiotis CA, Pratt MR. PMID: 31625393.
      View in: PubMed   Mentions:    Fields:    
    7. Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer. Trends Biochem Sci. 2019 12; 44(12):991-993. Halbrook CJ, Wahl DR, Lyssiotis CA. PMID: 31699584.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    8. Hiding in plain sight. Science. 2019 06 21; 364(6446):1132-1133. Halbrook CJ, Crawford HC. PMID: 31221844.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    9. ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis. Genes Dev. 2019 06 01; 33(11-12):641-655. Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM. PMID: 31048544.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. Metabolism Drives Carcinogenesis and Maintenance of Pancreatic Tumors. Cancer Discov. 2019 03; 9(3):326-328. Halbrook CJ, Nelson BS, Lysstiotis CA. PMID: 30824487.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metab. 2019 06 04; 29(6):1390-1399.e6. Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, Chang D, Biankin A, Shi J, Frankel TL, Crawford HC, Morton JP, Pasca di Magliano M, Lyssiotis CA. PMID: 30827862.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    12. Metabolism and epigenetics of pancreatic cancer stem cells. Semin Cancer Biol. 2019 08; 57:19-26. Perusina Lanfranca M, Thompson JK, Bednar F, Halbrook C, Lyssiotis C, Levi B, Frankel TL. PMID: 30273655.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    13. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. J Pathol. 2018 07; 245(3):324-336. Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER. PMID: 29672864.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation. Trends Endocrinol Metab. 2018 09; 29(9):599-602. Halbrook CJ, Nwosu ZC, Lyssiotis CA. PMID: 29692332.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    15. Tumor cross-talk networks promote growth and support immune evasion in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol. 2018 07 01; 315(1):G27-G35. Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. PMID: 29543507.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    16. Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. JCI Insight. 2018 01 25; 3(2). Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, Lyssiotis CA, Ljungman M, Morton JP, Galbán S, Fearon ER, Pasca di Magliano M. PMID: 29367463.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    17. Pancreatic HIF2a Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm. Cell Mol Gastroenterol Hepatol. 2018; 5(2):169-185.e2. Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M. PMID: 29693047.
      View in: PubMed   Mentions: 2     Fields:    
    18. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. Cancer Cell. 2017 01 09; 31(1):5-19. Halbrook CJ, Lyssiotis CA. PMID: 28073003.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    19. Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in Pancreatitis. Cell Mol Gastroenterol Hepatol. 2017 Jan; 3(1):99-118. Halbrook CJ, Wen HJ, Ruggeri JM, Takeuchi KK, Zhang Y, di Magliano MP, Crawford HC. PMID: 28090569.
      View in: PubMed   Mentions: 13     Fields:    
    20. PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance. Genes Dev. 2016 12 15; 30(24):2669-2683. Roy N, Takeuchi KK, Ruggeri JM, Bailey P, Chang D, Li J, Leonhardt L, Puri S, Hoffman MT, Gao S, Halbrook CJ, Song Y, Ljungman M, Malik S, Wright CV, Dawson DW, Biankin AV, Hebrok M, Crawford HC. PMID: 28087712.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016 12 01; 540(7631):150. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. PMID: 27706144.
      View in: PubMed   Mentions: 3     Fields:    
    22. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. 2016 08 25; 536(7617):479-83. Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. PMID: 27509858.
      View in: PubMed   Mentions: 181     Fields:    Translation:HumansAnimalsCells
    23. PI3K regulation of RAC1 is required for KRAS-induced pancreatic tumorigenesis in mice. Gastroenterology. 2014 Dec; 147(6):1405-16.e7. Wu CY, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ, Crawford HC. PMID: 25311989.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    24. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology. 2014 Jan; 146(1):233-44.e5. Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. PMID: 23999170.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    25. EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell. 2012 Sep 11; 22(3):304-17. Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT. PMID: 22975374.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
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