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Donovan, Peter J

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentBiological Chemistry
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-3691
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    TitleProfessor


    Collapse Research 
    Collapse Research Activities and Funding
    TCF3: A Wnt Pathway Effector in Pluripotent Stem Cell Self-Renewal
    NIH/NIGMS R01GM096017Sep 10, 2013 - Aug 31, 2018
    Role: Principal Investigator
    Training Program in Stem Cell Translational Medicine for Neurological Disorders
    NIH/NINDS T32NS082174Jul 1, 2013 - Jun 30, 2023
    Role: Co-Principal Investigator
    Stem Cell Derivation from Germ Cells
    NIH/NICHD R01HD049488May 1, 2005 - Apr 30, 2011
    Role: Principal Investigator
    Regulation of Female Meiosis by the Cdc25b Phosphatase
    NIH/NICHD R01HD041553Jun 1, 2002 - May 31, 2008
    Role: Principal Investigator
    Genetics of Germ Cell and Stem Cell Development
    NIH/NICHD R03HD041511Feb 1, 2002 - Jan 31, 2004
    Role: Principal Investigator
    CHROMOSOME SEGREGATION DURING FEMALE MEIOSIS
    NIH/NICHD R01HD038252Feb 16, 2001 - Jan 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sierra RA, Hoverter NP, Ramirez RN, Vuong LM, Mortazavi A, Merrill BJ, Waterman ML, Donovan P. TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency. Development. 2018 02 23; 145(4). PMID: 29361574.
      View in: PubMed
    2. Robinson PC, Dalbeth N, Donovan P. The Cost-effectiveness of Biannual Serum Urate (SU) Monitoring after Reaching Target in Gout: A Health Economic Analysis Comparing SU Monitoring. J Rheumatol. 2018 May; 45(5):697-704. PMID: 29449500.
      View in: PubMed
    3. Donovan P. Access to unregistered drugs in Australia. Aust Prescr. 2017 Oct; 40(5):194-196. PMID: 29109604.
      View in: PubMed
    4. Chew R, Jongbloed S, Jegatheesan D, Healy H, Ta K, Ungerer J, McWhinney B, Donovan P, Woods ML. Ethambutol Is Cleared by a Contemporary High-Flux Hemodialyzer, and Drug Monitoring Ensures Safety and Therapeutic Effect. Antimicrob Agents Chemother. 2017 06; 61(6). PMID: 28396542.
      View in: PubMed
    5. Myers B, Mitchell C, Whitty JA, Donovan P, Coombes I. Prescribing and medication communication on the post-take ward round. Intern Med J. 2017 Apr; 47(4):454-457. PMID: 28401716.
      View in: PubMed
    6. Donovan P, McLeod DS, Little R, Gordon L. Cost-utility analysis comparing radioactive iodine, anti-thyroid drugs and total thyroidectomy for primary treatment of Graves' disease. Eur J Endocrinol. 2016 Dec; 175(6):595-603. PMID: 27634939.
      View in: PubMed
    7. McRae PJ, Walker PJ, Peel NM, Hobson D, Parsonson F, Donovan P, Reade MC, Marquart L, Mudge AM. Frailty and Geriatric Syndromes in Vascular Surgical Ward Patients. Ann Vasc Surg. 2016 Aug; 35:9-18. PMID: 27238988.
      View in: PubMed
    8. Mathews DJ, Chan S, Donovan P, Douglas T, Gyngell C, Harris J, Regenberg A, Lovell-Badge R. CRISPR: A path through the thicket. Nature. 2015 Nov 12; 527(7577):159-61. PMID: 26560284.
      View in: PubMed
    9. Anuradha S, Donovan P, Webb PM, Brand AH, Goh J, Friedlander M, Oehler MK, Quinn M, Steer C, Jordan SJ. Variations in adjuvant chemotherapy and survival in women with epithelial ovarian cancer - a population-based study. Acta Oncol. 2016; 55(2):226-33. PMID: 26079434.
      View in: PubMed
    10. Donovan P, Achong N, Griffin K, Galligan J, Pretorius CJ, McLeod DS. PTHrP-mediated hypercalcemia: causes and survival in 138 patients. J Clin Endocrinol Metab. 2015 May; 100(5):2024-9. PMID: 25719931.
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    11. Chan S, Donovan P, Douglas T, Gyngell C, Harris J, Lovell-Badge R, Mathews DJ, Regenberg A. Genome Editing Technologies and Human Germline Genetic Modification: The Hinxton Group Consensus Statement. Am J Bioeth. 2015; 15(12):42-7. PMID: 26632362.
      View in: PubMed
    12. López-Iglesias P, Alcaina Y, Tapia N, Sabour D, Arauzo-Bravo MJ, Sainz de la Maza D, Berra E, O'Mara AN, Nistal M, Ortega S, Donovan P, Schöler HR, De Miguel MP. Hypoxia induces pluripotency in primordial germ cells by HIF1a stabilization and Oct4 deregulation. Antioxid Redox Signal. 2015 Jan 20; 22(3):205-23. PMID: 25226357.
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    13. Brunner EW, Jurewicz I, Heister E, Fahimi A, Bo C, Sear RP, Donovan P, Dalton AB. Growth and proliferation of human embryonic stem cells on fully synthetic scaffolds based on carbon nanotubes. ACS Appl Mater Interfaces. 2014 Feb 26; 6(4):2598-603. PMID: 24456005.
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    14. Donovan P, Sundac L, Pretorius CJ, d'Emden MC, McLeod DS. Calcitriol-mediated hypercalcemia: causes and course in 101 patients. J Clin Endocrinol Metab. 2013 Oct; 98(10):4023-9. PMID: 23979953.
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    15. Kong YP, Tu CH, Donovan P, Yee AF. Expression of Oct4 in human embryonic stem cells is dependent on nanotopographical configuration. Acta Biomater. 2013 May; 9(5):6369-80. PMID: 23391989.
      View in: PubMed
    16. Lucas C, Donovan P. 'Just a repeat' - When drug monitoring is indicated. Aust Fam Physician. 2013 Jan-Feb; 42(1-2):18-22. PMID: 23529454.
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    17. Donovan P, Wylie C. A lifetime of migration. Int J Dev Biol. 2013; 57(2-4):105-13. PMID: 23784820.
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    18. Donovan P, Iedema J, McLeod DS, Kubler P, Pillans P. Off-label use of recombinant factor VIIa in two tertiary hospitals in Queensland. ANZ J Surg. 2013 Mar; 83(3):149-54. PMID: 23137066.
      View in: PubMed
    19. Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan P, Gratton E. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Sci Rep. 2012; 2:568. PMID: 22891156; PMCID: PMC3416911.
    20. Pillans P, Iedema J, Donovan P, Newbery R, Whitehead V, Halliday C, Sheehy R, Springford A, Patterson T. Outcomes in patients with gram-negative sepsis treated with gentamicin. Ther Adv Drug Saf. 2012 Jun; 3(3):109-13. PMID: 25083229; PMCID: PMC4110825.
    21. Stringari C, Sierra R, Donovan P, Gratton E. Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy. J Biomed Opt. 2012 Apr; 17(4):046012. PMID: 22559690; PMCID: PMC3381030.
    22. Fong H, Wong RC, Donovan P. Transcriptional regulation of TRKC by SOX2 in human embryonic stem cells. Stem Cell Res. 2012 Mar; 8(2):206-14. PMID: 22265740.
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    23. Wong RC, Pollan S, Fong H, Ibrahim A, Smith EL, Ho M, Laslett AL, Donovan P. A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Stem Cells. 2011 Oct; 29(10):1517-27. PMID: 21898682.
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    24. Stringari C, Cinquin A, Cinquin O, Digman MA, Donovan P, Gratton E. Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13582-7. PMID: 21808026; PMCID: PMC3158156.
    25. Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan P. L1TD1 is a marker for undifferentiated human embryonic stem cells. PLoS One. 2011 Apr 29; 6(4):e19355. PMID: 21559406; PMCID: PMC3084827.
    26. Wong RC, Donovan P, Pébay A. Molecular mechanism involved in the maintenance of pluripotent stem cells. J Stem Cells. 2011; 6(4):213-32. PMID: 23550339.
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    27. Fong H, Elliott KA, Lock LF, Donovan P. Nucleofection of human embryonic stem cells. Methods Mol Biol. 2011; 767:333-41. PMID: 21822886.
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    28. Donovan P, McIntyre HD. Achievement of cardiovascular risk factor targets in young adults with diabetes mellitus. Diabetes Metab Syndr Obes. 2010 Nov 16; 3:387-94. PMID: 21437108; PMCID: PMC3047960.
    29. Easley CA, Ben-Yehudah A, Redinger CJ, Oliver SL, Varum ST, Eisinger VM, Carlisle DL, Donovan P, Schatten GP. mTOR-mediated activation of p70 S6K induces differentiation of pluripotent human embryonic stem cells. Cell Reprogram. 2010 Jun; 12(3):263-73. PMID: 20698768; PMCID: PMC2993047.
    30. Grier MC, Garrity-Ryan LK, Bartlett VJ, Klausner KA, Donovan P, Dudley C, Alekshun MN, Tanaka SK, Draper MP, Levy SB, Kim OK. N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability. Bioorg Med Chem Lett. 2010 Jun 01; 20(11):3380-3. PMID: 20434913.
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    31. Acharya MM, Christie LA, Lan ML, Donovan P, Cotman CW, Fike JR, Limoli CL. Rescue of radiation-induced cognitive impairment through cranial transplantation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):19150-5. PMID: 19901336; PMCID: PMC2776427.
    32. Shuda K, Schindler K, Ma J, Schultz RM, Donovan P. Aurora kinase B modulates chromosome alignment in mouse oocytes. Mol Reprod Dev. 2009 Nov; 76(11):1094-105. PMID: 19565641; PMCID: PMC3187553.
    33. Zeng W, de Greef JC, Chen YY, Chien R, Kong X, Gregson HC, Winokur ST, Pyle A, Robertson KD, Schmiesing JA, Kimonis VE, Balog J, Frants RR, Ball AR, Lock LF, Donovan P, van der Maarel SM, Yokomori K. Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet. 2009 Jul; 5(7):e1000559. PMID: 19593370; PMCID: PMC2700282.
    34. Mathews DJ, Donovan P, Harris J, Lovell-Badge R, Savulescu J, Faden R. Pluripotent stem cell-derived gametes: truth and (potential) consequences. Cell Stem Cell. 2009 Jul 02; 5(1):11-4. PMID: 19570509.
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    35. Pirino G, Wescott MP, Donovan P. Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. Cell Cycle. 2009 Feb 15; 8(4):665-70. PMID: 19223768.
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    36. Fong H, Hohenstein KA, Donovan P. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells. 2008 Aug; 26(8):1931-8. PMID: 18388306.
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    37. Hohenstein KA, Pyle AD, Chern JY, Lock LF, Donovan P. Nucleofection mediates high-efficiency stable gene knockdown and transgene expression in human embryonic stem cells. Stem Cells. 2008 Jun; 26(6):1436-43. PMID: 18323409; PMCID: PMC3882114.
    38. Elliott AM, de Miguel MP, Rebel VI, Donovan P. Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival. Dev Biol. 2007 Nov 15; 311(2):347-58. PMID: 17936260.
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    39. Vecchione A, Baldassarre G, Ishii H, Nicoloso MS, Belletti B, Petrocca F, Zanesi N, Fong LY, Battista S, Guarnieri D, Baffa R, Alder H, Farber JL, Donovan P, Croce CM. Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development. Cancer Cell. 2007 Mar; 11(3):275-89. PMID: 17349584; PMCID: PMC1987708.
    40. Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan P, Nussenzweig A, Sharan SK. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol. 2007 Feb 26; 176(5):581-92. PMID: 17312021; PMCID: PMC2064017.
    41. Kerr CL, Gearhart JD, Elliott AM, Donovan P. Embryonic germ cells: when germ cells become stem cells. Semin Reprod Med. 2006 Nov; 24(5):304-13. PMID: 17123225.
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    42. Minehata K, Takeuchi M, Hirabayashi Y, Inoue T, Donovan P, Tanaka M, Miyajima A. Oncostatin m maintains the hematopoietic microenvironment and retains hematopoietic progenitors in the bone marrow. Int J Hematol. 2006 Nov; 84(4):319-27. PMID: 17118758.
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    43. Mathews DJ, Donovan P, Harris J, Lovell-Badge R, Savulescu J, Faden R. Science and law. Integrity in international stem cell research collaborations. Science. 2006 Aug 18; 313(5789):921-2. PMID: 16917046.
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    44. Pyle AD, Lock LF, Donovan P. Neurotrophins mediate human embryonic stem cell survival. Nat Biotechnol. 2006 Mar; 24(3):344-50. PMID: 16444268.
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    45. Fenderson BA, De Miguel MP, Pyle AD, Donovan P. Staining embryonic stem cells using monoclonal antibodies to stage-specific embryonic antigens. Methods Mol Biol. 2006; 325:207-24. PMID: 16761728.
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    46. Greene M, Schill K, Takahashi S, Bateman-House A, Beauchamp T, Bok H, Cheney D, Coyle J, Deacon T, Dennett D, Donovan P, Flanagan O, Goldman S, Greely H, Martin L, Miller E, Mueller D, Siegel A, Solter D, Gearhart J, McKhann G, Faden R. Ethics: Moral issues of human-non-human primate neural grafting. Science. 2005 Jul 15; 309(5733):385-6. PMID: 16020716.
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    47. Dravid G, Ye Z, Hammond H, Chen G, Pyle A, Donovan P, Yu X, Cheng L. Defining the role of Wnt/beta-catenin signaling in the survival, proliferation, and self-renewal of human embryonic stem cells. Stem Cells. 2005 Nov-Dec; 23(10):1489-501. PMID: 16002782.
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    48. Ferguson AM, White LS, Donovan P, Piwnica-Worms H. Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases. Mol Cell Biol. 2005 Apr; 25(7):2853-60. PMID: 15767688; PMCID: PMC1061644.
    49. Pyle AD, Donovan P, Lock LF. Chipping away at 'stemness'. Genome Biol. 2004; 5(8):235. PMID: 15287966; PMCID: PMC507869.
    50. Schatten G, Donovan P. Embryology: plane talk. Nature. 2004 Jul 15; 430(6997):301-2. PMID: 15254521.
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    51. Morikawa Y, Tamura S, Minehata K, Donovan P, Miyajima A, Senba E. Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia. J Neurosci. 2004 Feb 25; 24(8):1941-7. PMID: 14985435.
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    52. Donovan P, de Miguel MP. Turning germ cells into stem cells. Curr Opin Genet Dev. 2003 Oct; 13(5):463-71. PMID: 14550410.
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    53. Donovan P, Reed SI. Germline exclusion of Cks1 in the mouse reveals a metaphase I role for Cks proteins in male and female meiosis. Cell Cycle. 2003 Jul-Aug; 2(4):275-6. PMID: 12851469.
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    54. Spruck CH, de Miguel MP, Smith AP, Ryan A, Stein P, Schultz RM, Lincoln AJ, Donovan P, Reed SI. Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Science. 2003 Apr 25; 300(5619):647-50. PMID: 12714746.
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    55. De Miguel MP, Donovan P. Determinants of retroviral-mediated gene delivery to mouse spermatogonia. Biol Reprod. 2003 Mar; 68(3):860-6. PMID: 12604636.
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    56. Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol. 2003 Mar; 5(3):242-8. PMID: 12577065.
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    57. De Miguel MP, Donovan P. Isolation and culture of embryonic germ cells. Methods Enzymol. 2003; 365:353-63. PMID: 14696358.
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    58. De Miguel MP, Cheng L, Holland EC, Federspiel MJ, Donovan P. Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10458-63. PMID: 12140361; PMCID: PMC124938.
    59. Gribaldo L, Alison M, Andrews PW, Bremer S, Donovan P, Knaän-Shanzer S, Mertelsmann R, Spielmann H, Testa NG, Triffitt JT, Zipori D, de Wynter E. Meeting summary: European Workshop on Stem Cells, European Centre for the Validation of Biomedical Testing Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy, November 21-23, 2001. Exp Hematol. 2002 Jul; 30(7):628-33. PMID: 12135658.
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    60. Lincoln AJ, Wickramasinghe D, Stein P, Schultz RM, Palko ME, De Miguel MP, Tessarollo L, Donovan P. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet. 2002 Apr; 30(4):446-9. PMID: 11912493.
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