Anderson, Aileen J

InstitutionUniversity of California, Irvine
DepartmentPhysical Medicine and Rehabilitation
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-6750
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    Human neural stem cell therapy for the treatment of cervical spinal cord injury (
    NIH/NINDS U01NS079420Sep 1, 2013 - Aug 31, 2016
    Role: Principal Investigator
    Controlled Release Scaffolds for Nerve Regeneration
    NIH/NIBIB R01EB005678Dec 1, 2005 - Dec 31, 2018
    Role: Co-Principal Investigator
    Mechanisms of SCI Recovery after hCNS Stem Cell Grafts
    NIH/NINDS R01NS049885Aug 2, 2004 - Apr 30, 2010
    Role: Principal Investigator
    Mechanisms of Complement-Mediated Damage in SCI
    NIH/NINDS R01NS043428Apr 1, 2003 - Mar 31, 2009
    Role: Principal Investigator
    NIH/NIMH F31MH010219Mar 27, 1992
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Anzalone A, Chacko JV, Nishi RA, Dumont C, Smith D, Shea LD, Digman MA, Cummings BJ, Anderson A. Feasibility study on mouse live imaging after spinal cord injury and poly(lactide-co-glycolide) bridge implantation. J Biomed Opt. 2018 Jun; 23(6):1-6. PMID: 29959835.
      View in: PubMed
    2. Park J, Decker JT, Margul DJ, Smith DR, Cummings BJ, Anderson A, Shea LD. Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury. Mol Ther. 2018 Apr 27. PMID: 29778523.
      View in: PubMed
    3. Piltti KM, Cummings BJ, Carta K, Manughian-Peter A, Worne CL, Singh K, Ong D, Maksymyuk Y, Khine M, Anderson A. Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells - Tools for analyzing dynamics of cell cycle, migration, and lineage selection. Methods. 2018 Jan 15; 133:81-90. PMID: 29050826.
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    4. Peterson SL, Nguyen HX, Mendez OA, Anderson A. Complement Protein C3 Suppresses Axon Growth and Promotes Neuron Loss. Sci Rep. 2017 Oct 10; 7(1):12904. PMID: 29018286.
      View in: PubMed
    5. Nguyen HX, Hooshmand MJ, Saiwai H, Maddox J, Salehi A, Lakatos A, Nishi RA, Salazar D, Uchida N, Anderson A. Systemic Neutrophil Depletion Modulates the Migration and Fate of Transplanted Human Neural Stem Cells to Rescue Functional Repair. J Neurosci. 2017 Sep 20; 37(38):9269-9287. PMID: 28847814.
      View in: PubMed
    6. Hooshmand MJ, Nguyen HX, Piltti KM, Benavente F, Hong S, Flanagan L, Uchida N, Cummings BJ, Anderson A. Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis. J Immunol. 2017 08 01; 199(3):1069-1085. PMID: 28687659.
      View in: PubMed
    7. Piltti KM, Funes GM, Avakian SN, Salibian AA, Huang KI, Carta K, Kamei N, Flanagan LA, Monuki ES, Uchida N, Cummings BJ, Anderson A. Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury. Stem Cell Reports. 2017 06 06; 8(6):1534-1548. PMID: 28479305.
      View in: PubMed
    8. Monuki ES, Anderson A, Blurton-Jones M, Cummings BJ. Response to StemCells Inc. Stem Cell Reports. 2017 Feb 14; 8(2):195-197. PMID: 28199827.
      View in: PubMed
    9. Anderson A, Piltti KM, Hooshmand MJ, Nishi RA, Cummings BJ. Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury. Stem Cell Reports. 2017 02 14; 8(2):249-263. PMID: 28199829.
      View in: PubMed
    10. Anderson A, Cummings BJ. Achieving Informed Consent for Cellular Therapies: A Preclinical Translational Research Perspective on Regulations versus a Dose of Reality. J Law Med Ethics. 2016 09; 44(3):394-401. PMID: 27587445.
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    11. Haus DL, López-Velázquez L, Gold EM, Cunningham KM, Perez H, Anderson A, Cummings BJ. Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury. Exp Neurol. 2016 07; 281:1-16. PMID: 27079998.
      View in: PubMed
    12. Piltti KM, Avakian SN, Funes GM, Hu A, Uchida N, Anderson A, Cummings BJ. Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury. Stem Cell Res. 2015 Sep; 15(2):341-53. PMID: 26298025; PMCID: PMC4600655.
    13. Pawar K, Cummings BJ, Thomas A, Shea LD, Levine A, Pfaff S, Anderson A. Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: Association with recovery of forelimb function. Biomaterials. 2015 Oct; 65:1-12. PMID: 26134079; PMCID: PMC4523232 [Available on 10/01/16].
    14. Kwon BK, Streijger F, Hill CE, Anderson A, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol. 2015 Jul; 269:154-68. PMID: 25902036.
      View in: PubMed
    15. Peterson SL, Nguyen HX, Mendez OA, Anderson A. Complement protein C1q modulates neurite outgrowth in vitro and spinal cord axon regeneration in vivo. J Neurosci. 2015 Mar 11; 35(10):4332-49. PMID: 25762679; PMCID: PMC4355202.
    16. Hooshmand MJ, Galvan MD, Partida E, Anderson A. Characterization of recovery, repair, and inflammatory processes following contusion spinal cord injury in old female rats: is age a limitation? Immun Ageing. 2014; 11:15. PMID: 25512759; PMCID: PMC4265993.
    17. Peterson SL, Anderson A. Complement and spinal cord injury: traditional and non-traditional aspects of complement cascade function in the injured spinal cord microenvironment. Exp Neurol. 2014 Aug; 258:35-47. PMID: 25017886.
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    18. Haus DL, Nguyen HX, Gold EM, Kamei N, Perez H, Moore HD, Anderson A, Cummings BJ. CD133-enriched Xeno-Free human embryonic-derived neural stem cells expand rapidly in culture and do not form teratomas in immunodeficient mice. Stem Cell Res. 2014 Sep; 13(2):214-26. PMID: 25082219.
      View in: PubMed
    19. Thomas AM, Seidlits SK, Goodman AG, Kukushliev TV, Hassani DM, Cummings BJ, Anderson A, Shea LD. Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Integr Biol (Camb). 2014 Jul 24; 6(7):694-705. PMID: 24873988; PMCID: PMC4086750.
    20. Nishimura S, Sasaki T, Shimizu A, Yoshida K, Iwai H, Koya I, Kobayashi Y, Itakura G, Shibata S, Ebise H, Horiuchi K, Kudoh J, Toyama Y, Anderson A, Okano H, Nakamura M. Global gene expression analysis following spinal cord injury in non-human primates. Exp Neurol. 2014 Nov; 261:171-9. PMID: 24873731.
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    21. Nguyen HX, Nekanti U, Haus DL, Funes G, Moreno D, Kamei N, Cummings BJ, Anderson A. Induction of early neural precursors and derivation of tripotent neural stem cells from human pluripotent stem cells under xeno-free conditions. J Comp Neurol. 2014 Aug 15; 522(12):2767-83. PMID: 24715528.
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    22. Sontag CJ, Uchida N, Cummings BJ, Anderson A. Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem Cell Reports. 2014 May 06; 2(5):620-32. PMID: 24936450; PMCID: PMC4050489.
    23. Tuinstra HM, Margul DJ, Goodman AG, Boehler RM, Holland SJ, Zelivyanskaya ML, Cummings BJ, Anderson A, Shea LD. Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration. Tissue Eng Part A. 2014 Mar; 20(5-6):1027-37. PMID: 24168314; PMCID: PMC3938917.
    24. Piltti KM, Salazar DL, Uchida N, Cummings BJ, Anderson A. Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem Cells Transl Med. 2013 Dec; 2(12):961-74. PMID: 24191264; PMCID: PMC3841091.
    25. Sontag CJ, Nguyen HX, Kamei N, Uchida N, Anderson A, Cummings BJ. Immunosuppressants affect human neural stem cells in vitro but not in an in vivo model of spinal cord injury. Stem Cells Transl Med. 2013 Oct; 2(10):731-44. PMID: 23981724; PMCID: PMC3785258.
    26. Gold EM, Su D, López-Velázquez L, Haus DL, Perez H, Lacuesta GA, Anderson A, Cummings BJ. Functional assessment of long-term deficits in rodent models of traumatic brain injury. Regen Med. 2013 Jul; 8(4):483-516. PMID: 23826701.
      View in: PubMed
    27. Piltti KM, Salazar DL, Uchida N, Cummings BJ, Anderson A. Safety of epicenter versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy. Stem Cells Transl Med. 2013 Mar; 2(3):204-16. PMID: 23413374; PMCID: PMC3659765.
    28. Thomas AM, Kubilius MB, Holland SJ, Seidlits SK, Boehler RM, Anderson A, Cummings BJ, Shea LD. Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury. Biomaterials. 2013 Mar; 34(9):2213-20. PMID: 23290832; PMCID: PMC3552139.
    29. Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T, Cummings BJ, Anderson A, Tamaki SJ, Tsukamoto A, Weissman IL, Matsumoto SG, Sherman LS, Kroenke CD, Back SA. Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci Transl Med. 2012 Oct 10; 4(155):155ra136. PMID: 23052293; PMCID: PMC3864816.
    30. Brennan FH, Anderson A, Taylor SM, Woodruff TM, Ruitenberg MJ. Complement activation in the injured central nervous system: another dual-edged sword? J Neuroinflammation. 2012 Jun 21; 9:137. PMID: 22721265; PMCID: PMC3464784.
    31. Tuinstra HM, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast AG, Ko SY, Margul DJ, Bartels AK, Boehler RM, Cummings BJ, Anderson A, Shea LD. Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury. Biomaterials. 2012 Feb; 33(5):1618-26. PMID: 22130565; PMCID: PMC3237872.
    32. Anderson A, Haus DL, Hooshmand MJ, Perez H, Sontag CJ, Cummings BJ. Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient? Regen Med. 2011 May; 6(3):367-406. PMID: 21548741; PMCID: PMC3403688.
    33. Nguyen HX, Beck KD, Anderson A. Quantitative assessment of immune cells in the injured spinal cord tissue by flow cytometry: a novel use for a cell purification method. J Vis Exp. 2011 Apr 09; (50). PMID: 21505412; PMCID: PMC3169264.
    34. Salazar DL, Uchida N, Hamers FP, Cummings BJ, Anderson A. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One. 2010 Aug 18; 5(8):e12272. PMID: 20806064; PMCID: PMC2923623.
    35. Luchetti S, Beck KD, Galvan MD, Silva R, Cummings BJ, Anderson A. Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injury. J Neurotrauma. 2010 Feb; 27(2):411-21. PMID: 19831737; PMCID: PMC2834443.
    36. Beck KD, Nguyen HX, Galvan MD, Salazar DL, Woodruff TM, Anderson A. Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment. Brain. 2010 Feb; 133(Pt 2):433-47. PMID: 20085927; PMCID: PMC2858013.
    37. Yang Y, De Laporte L, Zelivyanskaya ML, Whittlesey KJ, Anderson A, Cummings BJ, Shea LD. Multiple channel bridges for spinal cord injury: cellular characterization of host response. Tissue Eng Part A. 2009 Nov; 15(11):3283-95. PMID: 19382871; PMCID: PMC2792065.
    38. Hooshmand MJ, Sontag CJ, Uchida N, Tamaki S, Anderson A, Cummings BJ. Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS One. 2009 Jun 11; 4(6):e5871. PMID: 19517014; PMCID: PMC2690693.
    39. Galvan MD, Luchetti S, Burgos AM, Nguyen HX, Hooshmand MJ, Hamers FP, Anderson A. Deficiency in complement C1q improves histological and functional locomotor outcome after spinal cord injury. J Neurosci. 2008 Dec 17; 28(51):13876-88. PMID: 19091977; PMCID: PMC2680920.
    40. De Laporte L, Yang Y, Zelivyanskaya ML, Cummings BJ, Anderson A, Shea LD. Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury. Mol Ther. 2009 Feb; 17(2):318-26. PMID: 19050701; PMCID: PMC2835056.
    41. Nguyen HX, Galvan MD, Anderson A. Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury. J Neuroinflammation. 2008 Jun 25; 5:26. PMID: 18578885; PMCID: PMC2443364.
    42. Nguyen HX, O'Barr TJ, Anderson A. Polymorphonuclear leukocytes promote neurotoxicity through release of matrix metalloproteinases, reactive oxygen species, and TNF-alpha. J Neurochem. 2007 Aug; 102(3):900-12. PMID: 17561941.
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    43. Nishi RA, Liu H, Chu Y, Hamamura M, Su MY, Nalcioglu O, Anderson A. Behavioral, histological, and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice. J Neurotrauma. 2007 Apr; 24(4):674-89. PMID: 17439350.
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    44. Engesser-Cesar C, Ichiyama RM, Nefas AL, Hill MA, Edgerton VR, Cotman CW, Anderson A. Wheel running following spinal cord injury improves locomotor recovery and stimulates serotonergic fiber growth. Eur J Neurosci. 2007 Apr; 25(7):1931-9. PMID: 17439482.
      View in: PubMed
    45. Cummings BJ, Engesser-Cesar C, Cadena G, Anderson A. Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury. Behav Brain Res. 2007 Feb 27; 177(2):232-41. PMID: 17197044; PMCID: PMC1892162.
    46. Cummings BJ, Uchida N, Tamaki SJ, Anderson A. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol Res. 2006 Jul; 28(5):474-81. PMID: 16808875.
      View in: PubMed
    47. Basso DM, Fisher LC, Anderson A, Jakeman LB, McTigue DM, Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma. 2006 May; 23(5):635-59. PMID: 16689667.
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    48. Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson A. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):14069-74. PMID: 16172374; PMCID: PMC1216836.
    49. Garraway SM, Anderson A, Mendell LM. BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injury. J Neurophysiol. 2005 Sep; 94(3):1798-804. PMID: 15901762.
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    50. Anderson A, Najbauer J, Huang W, Young W, Robert S. Upregulation of complement inhibitors in association with vulnerable cells following contusion-induced spinal cord injury. J Neurotrauma. 2005 Mar; 22(3):382-97. PMID: 15785233.
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    51. Perreau VM, Adlard PA, Anderson A, Cotman CW. Exercise-induced gene expression changes in the rat spinal cord. Gene Expr. 2005; 12(2):107-21. PMID: 15892452.
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    52. Engesser-Cesar C, Anderson A, Basso DM, Edgerton VR, Cotman CW. Voluntary wheel running improves recovery from a moderate spinal cord injury. J Neurotrauma. 2005 Jan; 22(1):157-71. PMID: 15665610.
      View in: PubMed
    53. Anderson A, Robert S, Huang W, Young W, Cotman CW. Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma. 2004 Dec; 21(12):1831-46. PMID: 15684772.
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    54. Su JH, Anderson A, Cribbs DH, Tu C, Tong L, Kesslack P, Cotman CW. Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death. Neurobiol Dis. 2003 Apr; 12(3):182-93. PMID: 12742739.
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    55. Zhao M, Cribbs DH, Anderson A, Cummings BJ, Su JH, Wasserman AJ, Cotman CW. The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem Res. 2003 Feb; 28(2):307-18. PMID: 12608703.
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    56. Cummings BJ, Mason AJ, Kim RC, Sheu PC, Anderson A. Optimization of techniques for the maximal detection and quantification of Alzheimer's-related neuropathology with digital imaging. Neurobiol Aging. 2002 Mar-Apr; 23(2):161-70. PMID: 11804699.
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    57. Anderson A. Mechanisms and pathways of inflammatory responses in CNS trauma: spinal cord injury. J Spinal Cord Med. 2002; 25(2):70-9; discussion 80. PMID: 12137220.
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    58. Anderson A, Stoltzner S, Lai F, Su J, Nixon RA. Morphological and biochemical assessment of DNA damage and apoptosis in Down syndrome and Alzheimer disease, and effect of postmortem tissue archival on TUNEL. Neurobiol Aging. 2000 Jul-Aug; 21(4):511-24. PMID: 10924764.
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