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Schilling, Thomas F.

TitleProfessor, Department Chair
InstitutionUniversity of California, Irvine
DepartmentDevelopmental & Cell Biology
Address4109 Natural Sciences II
Zot 2305
CA 92697
Phone(949) 824-2479, 7203
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    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Morphogenesis and Extracellular Matrix Assembly at the Myotendinous Junction
    NIH/NIAMS R01AR067797Mar 1, 2016 - Feb 28, 2021
    Role: Principal Investigator
    Defining an Integrated Signaling Network That Patterns the Craniofacial Skeleton
    NIH/NIDCR R01DE023050Jul 1, 2014 - Mar 31, 2019
    Role: Co-Principal Investigator
    Stochastic Dynamics and Noise Control in Patterning Systems
    NIH/NIGMS R01GM107264Jul 1, 2014 - Jun 30, 2018
    Role: Co-Principal Investigator
    Regulation of Extracellular Matrix Assembly at the Myotendinous Junction
    NIH/NIAMS R21AR062792Mar 1, 2013 - Feb 28, 2015
    Role: Principal Investigator
    Understanding Head Development: A Segmental Groundplan of Vertebrates
    NIH/NICHD R13HD057707Jan 1, 2008 - Dec 31, 2008
    Role: Principal Investigator
    Zebrafish in Comparative Context: A Symposium
    NIH/NICHD R13HD052411Dec 1, 2005 - Nov 30, 2006
    Role: Principal Investigator
    Retinoid Signaling in Neural Patterning in Zebrafish
    NIH/NINDS R01NS041353Jun 15, 2001 - May 31, 2011
    Role: Principal Investigator
    Role and Regulation of Cellular Polarity in Craniofacial Skeletogenesis
    NIH/NIDCR R01DE013828Apr 1, 2001 - Jul 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Vorontsova I, Gehring I, Hall JE, Schilling T. Aqp0a Regulates Suture Stability in the Zebrafish Lens. Invest Ophthalmol Vis Sci. 2018 Jun 01; 59(7):2869-2879. PMID: 30025131.
      View in: PubMed
    2. Aguillon R, Batut J, Subramanian A, Madelaine R, Dufourcq P, Schilling T, Blader P. Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm. Elife. 2018 01 02; 7. PMID: 29292696.
      View in: PubMed
    3. Vibert L, Aquino G, Gehring I, Subkankulova T, Schilling T, Rocco A, Kelsh RN. An ongoing role for Wnt signaling in differentiating melanocytes in vivo. Pigment Cell Melanoma Res. 2017 Mar; 30(2):219-232. PMID: 27977907.
      View in: PubMed
    4. Wang Q, Holmes WR, Sosnik J, Schilling T, Nie Q. Cell Sorting and Noise-Induced Cell Plasticity Coordinate to Sharpen Boundaries between Gene Expression Domains. PLoS Comput Biol. 2017 Jan; 13(1):e1005307. PMID: 28135279.
      View in: PubMed
    5. Muto A, Schilling T. Zebrafish as a Model to Study Cohesin and Cohesinopathies. Methods Mol Biol. 2017; 1515:177-196. PMID: 27797080.
      View in: PubMed
    6. Nichols JT, Blanco-Sánchez B, Brooks EP, Parthasarathy R, Dowd J, Subramanian A, Nachtrab G, Poss KD, Schilling T, Kimmel CB. Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development. 2016 12 01; 143(23):4430-4440. PMID: 27789622.
      View in: PubMed
    7. Kawauchi S, Santos R, Muto A, Lopez-Burks ME, Schilling T, Lander AD, Calof AL. Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange Syndrome. Am J Med Genet C Semin Med Genet. 2016 06; 172(2):138-45. PMID: 27120001.
      View in: PubMed
    8. Sosnik J, Zheng L, Rackauckas CV, Digman M, Gratton E, Nie Q, Schilling T. Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. Elife. 2016 Apr 12; 5:e14034. PMID: 27067377; PMCID: PMC4829421.
    9. Le Pabic P, Cooper WJ, Schilling T. Developmental basis of phenotypic integration in two Lake Malawi cichlids. Evodevo. 2016; 7:3. PMID: 26798449; PMCID: PMC4721197.
    10. Subramanian A, Schilling T. Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix. Development. 2015 Dec 15; 142(24):4191-204. PMID: 26672092; PMCID: PMC4689213 [Available on 12/15/16].
    11. Serpa Neto A, Hemmes SN, Barbas CS, Beiderlinden M, Biehl M, Binnekade JM, Canet J, Fernandez-Bustamante A, Futier E, Gajic O, Hedenstierna G, Hollmann MW, Jaber S, Kozian A, Licker M, Lin WQ, Maslow AD, Memtsoudis SG, Reis Miranda D, Moine P, Ng T, Paparella D, Putensen C, Ranieri M, Scavonetto F, Schilling T, Schmid W, Selmo G, Severgnini P, Sprung J, Sundar S, Talmor D, Treschan T, Unzueta C, Weingarten TN, Wolthuis EK, Wrigge H, Gama de Abreu M, Pelosi P, Schultz MJ. Protective versus Conventional Ventilation for Surgery: A Systematic Review and Individual Patient Data Meta-analysis. Anesthesiology. 2015 Jul; 123(1):66-78. PMID: 25978326.
      View in: PubMed
    12. Cruz IA, Kappedal R, Mackenzie SM, Hailey DW, Hoffman TL, Schilling T, Raible DW. Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance. Dev Biol. 2015 Jun 15; 402(2):229-38. PMID: 25869855; PMCID: PMC4450121.
    13. Boer EF, Howell ED, Schilling T, Jette CA, Stewart RA. Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells. PLoS Genet. 2015 Jan; 11(1):e1004946. PMID: 25607881.
      View in: PubMed
    14. Le Pabic P, Ng C, Schilling T. Fat-Dachsous signaling coordinates cartilage differentiation and polarity during craniofacial development. PLoS Genet. 2014 Oct; 10(10):e1004726. PMID: 25340762; PMCID: PMC4207671.
    15. Muto A, Ikeda S, Lopez-Burks ME, Kikuchi Y, Calof AL, Lander AD, Schilling T. Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet. 2014 Sep; 10(9):e1004671. PMID: 25255084; PMCID: PMC4177752.
    16. Alexander C, Piloto S, Le Pabic P, Schilling T. Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genet. 2014 Jul; 10(7):e1004479. PMID: 25058015; PMCID: PMC4109847.
    17. Subramanian A, Schilling T. Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. Elife. 2014 Jun 18; 3. PMID: 24941943; PMCID: PMC4096842.
    18. Tuttle AM, Hoffman TL, Schilling T. Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration. PLoS Biol. 2014 May; 12(5):e1001852. PMID: 24802872; PMCID: PMC4011682.
    19. Clemens DM, Németh-Cahalan KL, Trinh L, Zhang T, Schilling T, Hall JE. In vivo analysis of aquaporin 0 function in zebrafish: permeability regulation is required for lens transparency. Invest Ophthalmol Vis Sci. 2013 Jul 30; 54(7):5136-43. PMID: 23800763; PMCID: PMC3729242.
    20. Wu B, Piloto S, Zeng W, Hoverter NP, Schilling T, Waterman ML. Ring Finger Protein 14 is a new regulator of TCF/ß-catenin-mediated transcription and colon cancer cell survival. EMBO Rep. 2013 Apr; 14(4):347-55. PMID: 23449499; PMCID: PMC3615654.
    21. Schilling T, Nie Q, Lander AD. Dynamics and precision in retinoic acid morphogen gradients. Curr Opin Genet Dev. 2012 Dec; 22(6):562-9. PMID: 23266215; PMCID: PMC3790664.
    22. Nguyen-Chi ME, Bryson-Richardson R, Sonntag C, Hall TE, Gibson A, Sztal T, Chua W, Schilling T, Currie PD. Morphogenesis and cell fate determination within the adaxial cell equivalence group of the zebrafish myotome. PLoS Genet. 2012; 8(10):e1003014. PMID: 23133395; PMCID: PMC3486873.
    23. Cai AQ, Radtke K, Linville A, Lander AD, Nie Q, Schilling T. Cellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish. Development. 2012 Jun; 139(12):2150-5. PMID: 22619388; PMCID: PMC3357909.
    24. de Pater E, Ciampricotti M, Priller F, Veerkamp J, Strate I, Smith K, Lagendijk AK, Schilling T, Herzog W, Abdelilah-Seyfried S, Hammerschmidt M, Bakkers J. Bmp signaling exerts opposite effects on cardiac differentiation. Circ Res. 2012 Feb 17; 110(4):578-87. PMID: 22247485; PMCID: PMC4924880.
    25. Zhang L, Radtke K, Zheng L, Cai AQ, Schilling T, Nie Q. Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain. Mol Syst Biol. 2012; 8:613. PMID: 23010996; PMCID: PMC3472692.
    26. Zuniga E, Rippen M, Alexander C, Schilling T, Crump JG. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development. 2011 Dec; 138(23):5147-56. PMID: 22031546; PMCID: PMC3210496.
    27. Alexander C, Zuniga E, Blitz IL, Wada N, Le Pabic P, Javidan Y, Zhang T, Cho KW, Crump JG, Schilling T. Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. Development. 2011 Dec; 138(23):5135-46. PMID: 22031543; PMCID: PMC3210495.
    28. Muto A, Calof AL, Lander AD, Schilling T. Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. 2011 Oct; 9(10):e1001181. PMID: 22039349; PMCID: PMC3201921.
    29. Clouthier DE, Garcia E, Schilling T. Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish. Am J Med Genet A. 2010 Dec; 152A(12):2962-73. PMID: 20684004; PMCID: PMC2974943.
    30. Froger A, Clemens D, Kalman K, Németh-Cahalan KL, Schilling T, Hall JE. Two distinct aquaporin 0s required for development and transparency of the zebrafish lens. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6582-92. PMID: 20671274; PMCID: PMC3055770.
    31. Piloto S, Schilling T. Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration. Development. 2010 Jun; 137(12):1981-90. PMID: 20463035; PMCID: PMC2875841.
    32. Schilling T, Le Pabic P. Fishing for the signals that pattern the face. J Biol. 2009; 8(11):101. PMID: 20067597.
      View in: PubMed
    33. Kuratani S, Schilling T. Head segmentation in vertebrates. Integr Comp Biol. 2008 Nov; 48(5):604-10. PMID: 20607135.
      View in: PubMed
    34. Linville A, Radtke K, Waxman JS, Yelon D, Schilling T. Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches. Dev Biol. 2009 Jan 01; 325(1):60-70. PMID: 18929555; PMCID: PMC3045866.
    35. White RJ, Schilling T. How degrading: Cyp26s in hindbrain development. Dev Dyn. 2008 Oct; 237(10):2775-90. PMID: 18816852; PMCID: PMC2880953.
    36. Nair S, Schilling T. Chemokine signaling controls endodermal migration during zebrafish gastrulation. Science. 2008 Oct 03; 322(5898):89-92. PMID: 18719251; PMCID: PMC2770598.
    37. Schilling T. Anterior-posterior patterning and segmentation of the vertebrate head. Integr Comp Biol. 2008 Nov; 48(5):658-67. PMID: 21669823; PMCID: PMC4938869.
    38. Currie PD, Schilling T, Ingham PW. Small-scale marker-based screening for mutations in zebrafish development. Methods Mol Biol. 2008; 461:493-512. PMID: 19030819.
      View in: PubMed
    39. White RJ, Nie Q, Lander AD, Schilling T. Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo. PLoS Biol. 2007 Nov; 5(11):e304. PMID: 18031199; PMCID: PMC2080651.
    40. Schilling T, Webb J. Considering the zebrafish in a comparative context. J Exp Zool B Mol Dev Evol. 2007 Sep 15; 308(5):515-22. PMID: 17688262.
      View in: PubMed
    41. Hoffman TL, Javier AL, Campeau SA, Knight RD, Schilling T. Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. J Exp Zool B Mol Dev Evol. 2007 Sep 15; 308(5):679-91. PMID: 17724731.
      View in: PubMed
    42. Bryson-Richardson RJ, Berger S, Schilling T, Hall TE, Cole NJ, Gibson AJ, Sharpe J, Currie PD. FishNet: an online database of zebrafish anatomy. BMC Biol. 2007 Aug 17; 5:34. PMID: 17705855; PMCID: PMC2031877.
    43. Plaster N, Sonntag C, Schilling T, Hammerschmidt M. REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development. Dev Dyn. 2007 Jul; 236(7):1891-904. PMID: 17576618.
      View in: PubMed
    44. Luo T, Xu Y, Hoffman TL, Zhang T, Schilling T, Sargent TD. Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development. Development. 2007 Apr; 134(7):1279-89. PMID: 17314132.
      View in: PubMed
    45. Nair S, Li W, Cornell R, Schilling T. Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish. Development. 2007 Jan; 134(2):335-45. PMID: 17166927.
      View in: PubMed
    46. Webb JF, Schilling T. Zebrafish in comparative context: A symposium. Integr Comp Biol. 2006 Oct; 46(5):569-76. PMID: 21672767.
      View in: PubMed
    47. Stafford D, White RJ, Kinkel MD, Linville A, Schilling T, Prince VE. Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development. 2006 Mar; 133(5):949-56. PMID: 16452093.
      View in: PubMed
    48. Knight RD, Schilling T. Cranial neural crest and development of the head skeleton. Adv Exp Med Biol. 2006; 589:120-33. PMID: 17076278.
      View in: PubMed
    49. Holzschuh J, Wada N, Wada C, Schaffer A, Javidan Y, Tallafuss A, Bally-Cuif L, Schilling T. Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development. 2005 Aug; 132(16):3731-42. PMID: 16077092.
      View in: PubMed
    50. Wada N, Javidan Y, Nelson S, Carney TJ, Kelsh RN, Schilling T. Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development. 2005 Sep; 132(17):3977-88. PMID: 16049113.
      View in: PubMed
    51. Knight RD, Javidan Y, Zhang T, Nelson S, Schilling T. AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo. Development. 2005 Jul; 132(13):3127-38. PMID: 15944192.
      View in: PubMed
    52. Norton WH, Mangoli M, Lele Z, Pogoda HM, Diamond B, Mercurio S, Russell C, Teraoka H, Stickney HL, Rauch GJ, Heisenberg CP, Houart C, Schilling T, Frohnhoefer HG, Rastegar S, Neumann CJ, Gardiner RM, Strähle U, Geisler R, Rees M, Talbot WS, Wilson SW. Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones. Development. 2005 Feb; 132(4):645-58. PMID: 15677724.
      View in: PubMed
    53. Linville A, Gumusaneli E, Chandraratna RA, Schilling T. Independent roles for retinoic acid in segmentation and neuronal differentiation in the zebrafish hindbrain. Dev Biol. 2004 Jun 01; 270(1):186-99. PMID: 15136149.
      View in: PubMed
    54. Clouthier DE, Schilling T. Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish. Birth Defects Res C Embryo Today. 2004 Jun; 72(2):190-9. PMID: 15269892.
      View in: PubMed
    55. Javidan Y, Schilling T. Development of cartilage and bone. Methods Cell Biol. 2004; 76:415-36. PMID: 15602885.
      View in: PubMed
    56. Knight RD, Javidan Y, Nelson S, Zhang T, Schilling T. Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development. Dev Dyn. 2004 Jan; 229(1):87-98. PMID: 14699580.
      View in: PubMed
    57. Knight RD, Nair S, Nelson SS, Afshar A, Javidan Y, Geisler R, Rauch GJ, Schilling T. lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development. 2003 Dec; 130(23):5755-68. PMID: 14534133.
      View in: PubMed
    58. Piotrowski T, Ahn DG, Schilling T, Nair S, Ruvinsky I, Geisler R, Rauch GJ, Haffter P, Zon LI, Zhou Y, Foott H, Dawid IB, Ho RK. The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development. 2003 Oct; 130(20):5043-52. PMID: 12952905.
      View in: PubMed
    59. David NB, Saint-Etienne L, Tsang M, Schilling T, Rosa FM. Requirement for endoderm and FGF3 in ventral head skeleton formation. Development. 2002 Oct; 129(19):4457-68. PMID: 12223404.
      View in: PubMed
    60. Yelick PC, Schilling T. Molecular dissection of craniofacial development using zebrafish. Crit Rev Oral Biol Med. 2002; 13(4):308-22. PMID: 12191958.
      View in: PubMed
    61. Schilling T, Knight RD. Origins of anteroposterior patterning and Hox gene regulation during chordate evolution. Philos Trans R Soc Lond B Biol Sci. 2001 Oct 29; 356(1414):1599-613. PMID: 11604126; PMCID: PMC1088539.
    62. Schilling T, Prince V, Ingham PW. Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Dev Biol. 2001 Mar 01; 231(1):201-16. PMID: 11180963.
      View in: PubMed
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