Geoffrey Winston Abbott

Title(s)Professor, Physiology and Biophysics
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-3269
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    Collapse Research 
    Collapse Research Activities and Funding
    GABA activation of the M-current
    NIH R01NS107671Mar 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Ion Channel Transporter Interactions
    NIH R35GM130377Feb 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Discovering the function of a putative ion channel family linked to inherited diseases
    NIH R21DC015982Mar 1, 2017 - Feb 29, 2020
    Role: Principal Investigator
    Real-time potassium channel subunit dynamics
    NIH R21DC015736Sep 20, 2016 - Aug 31, 2019
    Role: Principal Investigator
    Ion channel-transporter interactions
    NIH R01GM115189Apr 1, 2015 - Jan 31, 2019
    Role: Principal Investigator
    FASEB SRC on Ion Channel Regulation
    NIH R13NS083143Jun 1, 2013 - May 31, 2014
    Role: Principal Investigator
    Predictive multiscale modeling of atrial fibrillation for therapy development
    NIH R01HL101190Apr 12, 2010 - Mar 31, 2015
    Role: Co-Principal Investigator
    K+ Channel Trafficking and Modulation by Mink and MiRP1
    NIH R01HL079275Dec 15, 2004 - Apr 30, 2016
    Role: Principal Investigator
    Regulation of Kv3.1 by MiRPs in Auditory Neurons
    NIH R03DC007060Jul 1, 2004 - Jun 30, 2007
    Role: Principal Investigator
    Molecular Characterization of the Sodium/Iodide Symporter (NIS)
    NIH R01DK041544May 1, 1989 - Jul 31, 2019
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Protective effect of remote liver ischemic postconditioning on pulmonary ischemia and reperfusion injury in diabetic and non-diabetic rats. PLoS One. 2022; 17(5):e0268571. Huang D, Chen C, Zuo Y, Du L, Liu T, Abbott GW, Hu Z. PMID: 35617238.
      View in: PubMed   Mentions:
    2. Empagliflozin Protects against Pulmonary Ischemia/Reperfusion Injury via an Extracellular Signal-Regulated Kinases 1 and 2-Dependent Mechanism. J Pharmacol Exp Ther. 2022 03; 380(3):230-241. Huang D, Ju F, Du L, Liu T, Zuo Y, Abbott GW, Hu Z. PMID: 34893552.
      View in: PubMed   Mentions:
    3. The focal adhesion protein Testin modulates KCNE2 potassium channel β subunit activity. Channels (Austin). 2021 12; 15(1):229-238. Papanikolaou M, Crump SM, Abbott GW. PMID: 33464998; PMCID: PMC7833772.
      View in: PubMed   Mentions: 1     Fields:    
    4. Activation of SGK1.1 Upregulates the M-current in the Presence of Epilepsy Mutations. Front Mol Neurosci. 2021; 14:798261. Martin-Batista E, Manville RW, Rivero-Pérez B, Bartolomé-Martín D, Alvarez de la Rosa D, Abbott GW, Giraldez T. PMID: 34899186; PMCID: PMC8662703.
      View in: PubMed   Mentions:
    5. KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics. Front Physiol. 2021; 12:777057. Abbott GW, Redford KE, Yoshimura RF, Manville RW, Moreira L, Tran K, Arena G, Kookootsedes A, Lasky E, Gunnison E. PMID: 34858215; PMCID: PMC8632246.
      View in: PubMed   Mentions:
    6. Estimated SARS-CoV-2 infection rate and fatality risk in Gauteng Province, South Africa: a population-based seroepidemiological survey. Int J Epidemiol. 2021 Oct 30. Mutevedzi PC, Kawonga M, Kwatra G, Moultrie A, Baillie V, Mabena N, Mathibe MN, Rafuma MM, Maposa I, Abbott G, Hugo J, Ikalafeng B, Adelekan T, Lukhele M, Madhi SA. PMID: 34718591; PMCID: PMC8689871.
      View in: PubMed   Mentions:
    7. Severe Patients With ARDS With COVID-19 Treated With Extracorporeal Membrane Oxygenation in China: A Retrospective Study. Front Med (Lausanne). 2021; 8:699227. Lai W, Li S, Du Z, Ma X, Lu J, Gao WD, Abbott GW, Hu Z, Kang Y. PMID: 34746170; PMCID: PMC8563993.
      View in: PubMed   Mentions:
    8. Empagliflozin protects the heart against ischemia/reperfusion-induced sudden cardiac death. Cardiovasc Diabetol. 2021 10 04; 20(1):199. Hu Z, Ju F, Du L, Abbott GW. PMID: 34607570; PMCID: PMC8491391.
      View in: PubMed   Mentions:    Fields:    
    9. Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia. Circ Arrhythm Electrophysiol. 2021 10; 14(10):e010082. Ip JE, Xu L, Dai J, Steegborn C, Jaffré F, Evans T, Cheung JW, Basson CT, Panaghie G, Krogh-Madsen T, Abbott GW, Lerman BB. PMID: 34587755; PMCID: PMC8569928.
      View in: PubMed   Mentions:    Fields:    
    10. KCNQ Potassium Channels as Targets of Botanical Folk Medicines. Annu Rev Pharmacol Toxicol. 2022 01 06; 62:447-464. Redford KE, Abbott GW. PMID: 34516289.
      View in: PubMed   Mentions:    Fields:    
    11. The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels. Cell Physiol Biochem. 2021 Jul 28; 55(S3):157-170. Manville RW, Abbott GW. PMID: 34318654; PMCID: PMC8610427.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Intergenerational trauma transmission is associated with brain metabotranscriptome remodeling and mitochondrial dysfunction. Commun Biol. 2021 06 24; 4(1):783. Alhassen S, Chen S, Alhassen L, Phan A, Khoudari M, De Silva A, Barhoosh H, Wang Z, Parrocha C, Shapiro E, Henrich C, Wang Z, Mutesa L, Baldi P, Abbott GW, Alachkar A. PMID: 34168265; PMCID: PMC8225861.
      View in: PubMed   Mentions: Translation:HumansAnimalsCells
    13. Fluorescence Fluctuation Spectroscopy enables quantification of potassium channel subunit dynamics and stoichiometry. Sci Rep. 2021 05 21; 11(1):10719. Tedeschi G, Scipioni L, Papanikolaou M, Abbott GW, Digman MA. PMID: 34021177; PMCID: PMC8140153.
      View in: PubMed   Mentions:    Fields:    
    14. The envelope protein of SARS-CoV-2 increases intra-Golgi pH and forms a cation channel that is regulated by pH. J Physiol. 2021 06; 599(11):2851-2868. Cabrera-Garcia D, Bekdash R, Abbott GW, Yazawa M, Harrison NL. PMID: 33709461; PMCID: PMC8251088.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    15. KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea. Cell Physiol Biochem. 2021 Mar 06; 55(S3):46-64. Redford KE, Rognant S, Jepps TA, Abbott GW. PMID: 33667331; PMCID: PMC8612027.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    16. Dynein regulates Kv7.4 channel trafficking from the cell membrane. J Gen Physiol. 2021 03 01; 153(3). van der Horst J, Rognant S, Abbott GW, Ozhathil LC, Hägglund P, Barrese V, Chuang CY, Jespersen T, Davies MJ, Greenwood IA, Gourdon P, Aalkjær C, Jepps TA. PMID: 33533890; PMCID: PMC7863719.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    17. Control of Biophysical and Pharmacological Properties of Potassium Channels by Ancillary Subunits. Handb Exp Pharmacol. 2021; 267:445-480. Abbott GW. PMID: 34247280; PMCID: PMC8648496.
      View in: PubMed   Mentions:    Fields:    
    18. Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis. Commun Biol. 2020 07 30; 3(1):409. Chen S, Alhassen W, Yoshimura R, De Silva A, Abbott GW, Baldi P, Alachkar A. PMID: 32732995; PMCID: PMC7393105.
      View in: PubMed   Mentions: 1  Translation:HumansAnimalsCells
    19. The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator. Commun Biol. 2020 07 08; 3(1):356. Redford KE, Abbott GW. PMID: 32641720; PMCID: PMC7343821.
      View in: PubMed   Mentions: 1  Translation:AnimalsCells
    20. Author Correction: Allosteric regulation of mammalian Na+/I- symporter activity by perchlorate. Nat Struct Mol Biol. 2020 Jul; 27(7):683. Llorente-Esteban A, Manville RW, Reyna-Neyra A, Abbott GW, Amzel LM, Carrasco N. PMID: 32472109.
      View in: PubMed   Mentions:    Fields:    
    21. Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion. FASEB J. 2020 08; 34(8):10699-10719. Lisewski U, Köhncke C, Schleussner L, Purfürst B, Lee SM, De Silva A, Manville RW, Abbott GW, Roepke TK. PMID: 32584506; PMCID: PMC8638375.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    22. KCNQs: Ligand- and Voltage-Gated Potassium Channels. Front Physiol. 2020; 11:583. Abbott GW. PMID: 32655402; PMCID: PMC7324551.
      View in: PubMed   Mentions: 6  
    23. Allosteric regulation of mammalian Na+/I- symporter activity by perchlorate. Nat Struct Mol Biol. 2020 06; 27(6):533-539. Llorente-Esteban A, Manville RW, Reyna-Neyra A, Abbott GW, Amzel LM, Carrasco N. PMID: 32451489.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine. J Pharmacol Exp Ther. 2020 06; 373(3):391-401. Manville RW, Abbott GW. PMID: 32217768; PMCID: PMC7228494.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    25. Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly. Arterioscler Thromb Vasc Biol. 2020 05; 40(5):1207-1219. van der Horst J, Manville RW, Hayes K, Thomsen MB, Abbott GW, Jepps TA. PMID: 32188278; PMCID: PMC7180128.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    26. Potassium channels act as chemosensors for solute transporters. Commun Biol. 2020 02 28; 3(1):90. Manville RW, Abbott GW. PMID: 32111967; PMCID: PMC7048750.
      View in: PubMed   Mentions: 7  Translation:HumansAnimalsCells
    27. M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate. J Pharmacol Exp Ther. 2020 02; 372(2):148-156. Manville RW, Papanikolaou M, Abbott GW. PMID: 31757819; PMCID: PMC6994816.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner. Commun Biol. 2019; 2:401. Manville RW, Abbott GW. PMID: 31701029; PMCID: PMC6825221.
      View in: PubMed   Mentions: 3  Translation:Animals
    29. KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21236-21245. Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW. PMID: 31570602; PMCID: PMC6800379.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    30. Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies. Mol Neuropsychiatry. 2019 Oct; 5(4):200-211. Vawter MP, Hamzeh AR, Muradyan E, Civelli O, Abbott GW, Alachkar A. PMID: 31768373; PMCID: PMC6873027.
      View in: PubMed   Mentions: 1  
    31. Cilantro leaf harbors a potent potassium channel-activating anticonvulsant. FASEB J. 2019 10; 33(10):11349-11363. Manville RW, Abbott GW. PMID: 31311306; PMCID: PMC6766653.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    32. The KCNE2 potassium channel β subunit is required for normal lung function and resilience to ischemia and reperfusion injury. FASEB J. 2019 09; 33(9):9762-9774. Zhou L, Köhncke C, Hu Z, Roepke TK, Abbott GW. PMID: 31162977; PMCID: PMC6704464.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    33. Teamwork: Ion channels and transporters join forces in the brain. Neuropharmacology. 2019 12 15; 161:107601. Manville RW, Abbott GW. PMID: 30959022; PMCID: PMC7737636.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    34. Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice. Am J Physiol Regul Integr Comp Physiol. 2019 05 01; 316(5):R552-R562. Hu Z, Jepps TA, Zhou L, Liu J, Li M, Abbott GW. PMID: 30758982.
      View in: PubMed   Mentions: Translation:AnimalsCells
    35. AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death. Physiol Rep. 2019 02; 7(3):e13957. Hu Z, Liu J, Zhou L, Tian X, Abbott GW. PMID: 30737904; PMCID: PMC6368489.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity. J Cell Physiol. 2019 08; 234(8):13361-13369. Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW. PMID: 30613966; PMCID: PMC6478532.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    37. Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. Sci Adv. 2018 11; 4(11):eaav0824. De Silva AM, Manville RW, Abbott GW. PMID: 30443601; PMCID: PMC6235520.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia. FASEB J. 2019 02; 33(2):2537-2552. David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW. PMID: 30289750; PMCID: PMC6338634.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    39. Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket. Nat Commun. 2018 09 21; 9(1):3845. Manville RW, Abbott GW. PMID: 30242262; PMCID: PMC6155021.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    40. Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels. Mol Pharmacol. 2018 10; 94(4):1155-1163. Manville RW, Abbott GW. PMID: 30021858; PMCID: PMC6108572.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    41. Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. Sci Rep. 2018 05 29; 8(1):8258. Hu Z, Wei W, Zhou L, Chen M, Abbott GW. PMID: 29844497; PMCID: PMC5974354.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    42. Remote ischemic preconditioning STAT3-dependently ameliorates pulmonary ischemia/reperfusion injury. PLoS One. 2018; 13(5):e0196186. Luo N, Liu J, Chen Y, Li H, Hu Z, Abbott GW. PMID: 29768493; PMCID: PMC5955491.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    43. Direct neurotransmitter activation of voltage-gated potassium channels. Nat Commun. 2018 05 10; 9(1):1847. Manville RW, Papanikolaou M, Abbott GW. PMID: 29748663; PMCID: PMC5945843.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    44. β Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation. Front Physiol. 2017; 8:646. Abbott GW. PMID: 28919864; PMCID: PMC5585193.
      View in: PubMed   Mentions:
    45. Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Mol Psychiatry. 2018 02; 23(2):282-294. Alachkar A, Wang L, Yoshimura R, Hamzeh AR, Wang Z, Sanathara N, Lee SM, Xu X, Abbott GW, Civelli O. PMID: 28809400; PMCID: PMC6432924.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    46. SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore. Biophys J. 2017 Aug 08; 113(3):613-626. Manville RW, Neverisky DL, Abbott GW. PMID: 28793216; PMCID: PMC5550323.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    47. Chansporter complexes in cell signaling. FEBS Lett. 2017 09; 591(17):2556-2576. Abbott GW. PMID: 28718502; PMCID: PMC5678956.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    48. Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats. Cardiovasc Diabetol. 2017 04 26; 16(1):57. Hu Z, Chen M, Zhang P, Liu J, Abbott GW. PMID: 28446231; PMCID: PMC5406986.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    49. Targeted deletion of Kcne3 impairs skeletal muscle function in mice. FASEB J. 2017 07; 31(7):2937-2947. King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW. PMID: 28356343; PMCID: PMC5472403.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    50. KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. FASEB J. 2017 07; 31(7):2828-2838. Neverisky DL, Abbott GW. PMID: 28283543; PMCID: PMC5472404.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    51. Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus. FASEB J. 2017 06; 31(6):2674-2685. Lee SM, Baik J, Nguyen D, Nguyen V, Liu S, Hu Z, Abbott GW. PMID: 28280005.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    52. β Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants. Front Physiol. 2017; 8:66. Abbott GW. PMID: 28228734; PMCID: PMC5296356.
      View in: PubMed   Mentions: 4  
    53. Involvement of glycogen synthase kinase-3β in liver ischemic conditioning induced cardioprotection against myocardial ischemia and reperfusion injury in rats. J Appl Physiol (1985). 2017 May 01; 122(5):1095-1105. Yang S, Abbott GW, Gao WD, Liu J, Luo C, Hu Z. PMID: 28153944; PMCID: PMC5451530.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    54. Correction: Channel-transporter complexes: an emerging theme in cell signalling. Biochem J. 2016 12 15; 473(24):4714. Abbott GW. PMID: 27941032.
      View in: PubMed   Mentions:    Fields:    
    55. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. Sci Rep. 2016 12 06; 6:38412. Abbott GW. PMID: 27922120; PMCID: PMC5138848.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    56. Channel-transporter complexes: an emerging theme in cell signaling. Biochem J. 2016 11 01; 473(21):3759-3763. Abbott GW. PMID: 27789743; PMCID: PMC6506266.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    57. Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3β-Dependent Mechanism. PLoS One. 2016; 11(10):e0165123. Hu Z, Hu S, Yang S, Chen M, Zhang P, Liu J, Abbott GW. PMID: 27768739; PMCID: PMC5074543.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    58. Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity. J Vasc Res. 2016; 53(3-4):138-148. Abbott GW, Jepps TA. PMID: 27710966; PMCID: PMC5166573.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    59. KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis. Gene. 2016 Nov 30; 593(2):249-60. Abbott GW. PMID: 27484720; PMCID: PMC5166581.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    60. Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4. FASEB J. 2016 08; 30(8):2959-69. Abbott GW. PMID: 27162025; PMCID: PMC6137956.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    61. Ion channel-transporter interactions. Crit Rev Biochem Mol Biol. 2015 Jul-Aug; 51(4):257-67. Neverisky DL, Abbott GW. PMID: 27098917; PMCID: PMC5215868.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    62. KCNE2 and gastric cancer: bench to bedside. Oncotarget. 2016 Apr 05; 7(14):17286-7. Abbott GW, Roepke TK. PMID: 26956055; PMCID: PMC4951210.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    63. Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia. Sci Rep. 2016 Mar 17; 6:23118. Lee SM, Nguyen D, Anand M, Kant R, Köhncke C, Lisewski U, Roepke TK, Hu Z, Abbott GW. PMID: 26984260; PMCID: PMC4794722.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    64. Kcne2 deletion attenuates acute post-ischaemia/reperfusion myocardial infarction. Cardiovasc Res. 2016 May 15; 110(2):227-37. Hu Z, Crump SM, Zhang P, Abbott GW. PMID: 26952045; PMCID: PMC4836628.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    65. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene. 2016 Jan 15; 576(1 Pt 1):1-13. Abbott GW. PMID: 26410412; PMCID: PMC4917010.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    66. Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice. FASEB J. 2016 Jan; 30(1):360-9. Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. PMID: 26399785; PMCID: PMC4684512.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    67. Pharmacogenetic diversification by alternative translation initiation: background channels to the fore: Commentary on Kisselbach et al., Br J Pharmacol 171: 5182-5194. Br J Pharmacol. 2015 Sep; 172(18):4591-4593. Abbott GW. PMID: 24528336; PMCID: PMC4562518.
      View in: PubMed   Mentions:    Fields:    
    68. Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death. J Mol Cell Cardiol. 2015 Oct; 87:148-51. Lee SM, Nguyen D, Hu Z, Abbott GW. PMID: 26307149.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    69. The KCNE2 K⁺ channel regulatory subunit: Ubiquitous influence, complex pathobiology. Gene. 2015 Sep 15; 569(2):162-72. Abbott GW. PMID: 26123744; PMCID: PMC4917011.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    70. Ion channels under the sun. FASEB J. 2014 May; 28(5):1957-62. Abbott GW, Pitt GS. PMID: 24786286; PMCID: PMC3986833.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    71. KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Sci Signal. 2014 Mar 04; 7(315):ra22. Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT. PMID: 24595108; PMCID: PMC4063528.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    72. Arrhythmogenic KCNE gene variants: current knowledge and future challenges. Front Genet. 2014; 5:3. Crump SM, Abbott GW. PMID: 24478792; PMCID: PMC3900874.
      View in: PubMed   Mentions: 14  
    73. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014 Feb 28; 289(9):5889-903. Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ. PMID: 24403084; PMCID: PMC3937658.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    74. Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death. Circ Cardiovasc Genet. 2014 Feb; 7(1):33-42. Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW. PMID: 24403551; PMCID: PMC4917016.
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    75. NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS One. 2013; 8(12):e82951. Kant R, Hu Z, Malhotra JK, Krogh-Madsen T, Christini DJ, Heerdt PM, Abbott GW. PMID: 24376615; PMCID: PMC3871617.
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    76. Kcne3 deletion initiates extracardiac arrhythmogenesis in mice. FASEB J. 2014 Feb; 28(2):935-45. Hu Z, Crump SM, Anand M, Kant R, Levi R, Abbott GW. PMID: 24225147; PMCID: PMC3898654.
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    77. Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. J Physiol Sci. 2013 Jul; 63(4):251-61. Hu ZY, Abbott GW, Fang YD, Huang YS, Liu J. PMID: 23625523.
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    78. KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing? Expert Rev Clin Pharmacol. 2013 Jan; 6(1):49-60. Abbott GW. PMID: 23272793; PMCID: PMC4917007.
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    79. Interaction between soluble and membrane-embedded potassium channel peptides monitored by Fourier transform infrared spectroscopy. PLoS One. 2012; 7(11):e49070. Abbott GW, Ramesh B, Srai SK. PMID: 23145073; PMCID: PMC3493504.
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    80. Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One. 2012; 7(8):e42756. Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA. PMID: 22880098; PMCID: PMC3411840.
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    81. KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task? Front Physiol. 2012; 3:231. Kanda VA, Abbott GW. PMID: 22754540; PMCID: PMC3385356.
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    82. Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. J Mol Cell Cardiol. 2012 Sep; 53(3):350-3. Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW. PMID: 22641150; PMCID: PMC3418454.
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    83. The KCNQ1-KCNE2 K⁺ channel is required for adequate thyroid I⁻ uptake. FASEB J. 2012 Aug; 26(8):3252-9. Purtell K, Paroder-Belenitsky M, Reyna-Neyra A, Nicola JP, Koba W, Fine E, Carrasco N, Abbott GW. PMID: 22549510; PMCID: PMC3405278.
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    84. Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS Comput Biol. 2012; 8(2):e1002390. Krogh-Madsen T, Abbott GW, Christini DJ. PMID: 22383869; PMCID: PMC3285569.
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    85. KCNE2 and the K (+) channel: the tail wagging the dog. Channels (Austin). 2012 Jan-Feb; 6(1):1-10. Abbott GW. PMID: 22513486; PMCID: PMC3367673.
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    86. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Biophys J. 2011 Sep 21; 101(6):1354-63. Kanda VA, Lewis A, Xu X, Abbott GW. PMID: 21943416; PMCID: PMC3177047.
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    87. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel α-subunit composition. Biophys J. 2011 Sep 21; 101(6):1364-75. Kanda VA, Lewis A, Xu X, Abbott GW. PMID: 21943417; PMCID: PMC3177048.
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    88. KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec; 25(12):4264-73. Roepke TK, Kanda VA, Purtell K, King EC, Lerner DJ, Abbott GW. PMID: 21859894; PMCID: PMC3236621.
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    89. Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Heart Rhythm. 2011 Oct; 8(10):1641-7. Kanda VA, Purtell K, Abbott GW. PMID: 21699843; PMCID: PMC3183296.
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    90. Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 2011 Feb; 25(2):727-36. Roepke TK, King EC, Purtell K, Kanda VA, Lerner DJ, Abbott GW. PMID: 21084694; PMCID: PMC3023397.
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    91. Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. Int J Biochem Cell Biol. 2010 Nov; 42(11):1767-70. Purtell K, Roepke TK, Abbott GW. PMID: 20688187; PMCID: PMC2950229.
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    92. Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Rev Cardiovasc Ther. 2010 Aug; 8(8):1161-73. Harkcom WT, Abbott GW. PMID: 20670193; PMCID: PMC2921896.
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    93. Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One. 2010 Jul 06; 5(7):e11451. Roepke TK, Purtell K, King EC, La Perle KM, Lerner DJ, Abbott GW. PMID: 20625512; PMCID: PMC2897890.
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    94. A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor. FASEB J. 2010 May; 24(5):1518-24. Choi E, Abbott GW. PMID: 20040519; PMCID: PMC2879946.
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    95. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nat Med. 2009 Oct; 15(10):1186-94. Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW. PMID: 19767733; PMCID: PMC2790327.
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    96. Dynamical mechanism for subcellular alternans in cardiac myocytes. Circ Res. 2009 Aug 14; 105(4):335-42. Gaeta SA, Bub G, Abbott GW, Christini DJ. PMID: 19628792; PMCID: PMC2740370.
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    97. HERG biosynthesis: the positive influence of negative charge. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1211-2. Abbott GW, Roepke TK. PMID: 19286960; PMCID: PMC2685362.
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    98. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J Membr Biol. 2009 Mar; 228(1):1-14. McCrossan ZA, Roepke TK, Lewis A, Panaghie G, Abbott GW. PMID: 19219384; PMCID: PMC2849987.
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    99. MinK-dependent internalization of the IKs potassium channel. Cardiovasc Res. 2009 Jun 01; 82(3):430-8. Xu X, Kanda VA, Choi E, Panaghie G, Roepke TK, Gaeta SA, Christini DJ, Lerner DJ, Abbott GW. PMID: 19202166; PMCID: PMC2682613.
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    100. Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB J. 2008 Oct; 22(10):3648-60. Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. PMID: 18603586; PMCID: PMC2537427.
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    101. Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophys J. 2008 Sep 15; 95(6):2759-78. Panaghie G, Purtell K, Tai KK, Abbott GW. PMID: 18567635; PMCID: PMC2527255.
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    102. Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels. J Pharmacol Exp Ther. 2008 Sep; 326(3):871-8. Morrey C, Estephan R, Abbott GW, Levi R. PMID: 18523159; PMCID: PMC2577049.
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    103. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008 May 22; 453(7194):524-8. Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. PMID: 18432194.
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    104. Pharmacogenetics of drug-induced arrhythmias. Expert Rev Clin Pharmacol. 2008 Jan; 1(1):93-104. Abbott GW, Roepke TK. PMID: 24410513.
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    105. Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. Protein Pept Lett. 2008; 15(1):63-75. Abbott GW, Ramesh B, Srai SK. PMID: 18221016.
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    106. Impact of ancillary subunits on ventricular repolarization. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S42-6. Abbott GW, Xu X, Roepke TK. PMID: 17993327; PMCID: PMC2128763.
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    107. A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovasc Res. 2008 Jan; 77(1):98-106. Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, Abbott GW. PMID: 18006462.
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    108. The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease. Mol Pharmacol. 2007 Sep; 72(3):499-501. Choi E, Abbott GW. PMID: 17595326.
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    109. The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J Gen Physiol. 2007 Feb; 129(2):121-33. Panaghie G, Abbott GW. PMID: 17227916; PMCID: PMC2154355.
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    110. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem. 2006 Aug 18; 281(33):23740-7. Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. PMID: 16754665.
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    111. Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. FASEB J. 2006 Feb; 20(2):293-301. Abbott GW, Butler MH, Goldstein SA. PMID: 16449802.
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    112. The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Curr Pharm Des. 2006; 12(18):2285-302. Panaghie G, Abbott GW. PMID: 16787255.
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    113. Molecular mechanisms of cardiac voltage-gated potassium channelopathies. Curr Pharm Des. 2006; 12(28):3631-44. Abbott GW. PMID: 17073664.
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    114. Pharmacogenetics and cardiac ion channels. Vascul Pharmacol. 2006 Feb; 44(2):90-106. Roepke TK, Abbott GW. PMID: 16344000.
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    115. Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies. Biophys J. 2006 Feb 15; 90(4):1223-31. Gordon E, Roepke TK, Abbott GW. PMID: 16326911; PMCID: PMC1367273.
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    116. 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar; 69(3):718-26. Gordon E, Cohen JL, Engel R, Abbott GW. PMID: 16317109.
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    117. Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol. 2006 Feb 01; 570(Pt 3):455-67. Panaghie G, Tai KK, Abbott GW. PMID: 16308347; PMCID: PMC1479883.
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    118. Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther. 2005 Nov; 315(2):517-25. Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. PMID: 16033909.
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    119. Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1. Novartis Found Symp. 2005; 266:100-12; discussion 112-7, 155-8. Anantharam A, Abbott GW. PMID: 16050264.
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    120. The MinK-related peptides. Neuropharmacology. 2004 Nov; 47(6):787-821. McCrossan ZA, Abbott GW. PMID: 15527815.
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    121. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J Biol Chem. 2004 Feb 27; 279(9):7884-92. Lewis A, McCrossan ZA, Abbott GW. PMID: 14679187.
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    122. Pharmacogenetic considerations in diseases of cardiac ion channels. J Pharmacol Exp Ther. 2003 Dec; 307(3):831-8. Anantharam A, Markowitz SM, Abbott GW. PMID: 14561846.
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    123. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci. 2003 Sep 03; 23(22):8077-91. McCrossan ZA, Lewis A, Panaghie G, Jordan PN, Christini DJ, Lerner DJ, Abbott GW. PMID: 12954870; PMCID: PMC6740484.
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    124. Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. J Neurochem. 2003 Mar; 84(5):1193-200. Tai KK, McCrossan ZA, Abbott GW. PMID: 12603842.
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    125. RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. J Biol Chem. 2003 Apr 04; 278(14):11739-45. Anantharam A, Lewis A, Panaghie G, Gordon E, McCrossan ZA, Lerner DJ, Abbott GW. PMID: 12529362.
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    126. Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB J. 2002 Mar; 16(3):390-400. Abbott GW, Goldstein SA. PMID: 11874988.
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    127. Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). Mol Interv. 2001 Jun; 1(2):95-107. Abbott GW, Goldstein SA. PMID: 14993329.
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    128. Do all voltage-gated potassium channels use MiRPs? Circ Res. 2001 May 25; 88(10):981-3. Abbott GW, Goldstein SA, Sesti F. PMID: 11375265.
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    129. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell. 2001 Jan 26; 104(2):217-31. Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, Goldstein SA. PMID: 11207363.
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    130. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10613-8. Sesti F, Abbott GW, Wei J, Murray KT, Saksena S, Schwartz PJ, Priori SG, Roden DM, George AL, Goldstein SA. PMID: 10984545; PMCID: PMC27073.
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    131. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16; 97(2):175-87. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. PMID: 10219239.
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    132. A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q Rev Biophys. 1998 Nov; 31(4):357-98. Abbott GW, Goldstein SA. PMID: 10709243.
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    133. Conformational changes in a mammalian voltage-dependent potassium channel inactivation peptide. Biochemistry. 1998 Feb 10; 37(6):1640-5. Abbott GW, Mercer EA, Miller RT, Ramesh B, Srai SK. PMID: 9484235.
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    134. Secondary structure, stability and tetramerisation of recombinant K(V)1.1 potassium channel cytoplasmic N-terminal fragment. Biochim Biophys Acta. 1997 Aug 15; 1341(1):71-8. Abbott GW, Bloemendal M, Van Stokkum IH, Mercer EA, Miller RT, Sewing S, Wolters M, Pongs O, Srai SK. PMID: 9300810.
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    135. Synthetic putative transmembrane region of minimal potassium channel protein (minK) adopts an alpha-helical conformation in phospholipid membranes. Biochem J. 1997 Jul 15; 325 ( Pt 2):475-9. Mercer EA, Abbott GW, Brazier SP, Ramesh B, Haris PI, Srai SK. PMID: 9230130; PMCID: PMC1218584.
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    136. Structure analysis of a recombinant voltage-gated potassium channel (Kv1.1) N-terminus using FTIR spectroscopy and thermal denaturation. Biochem Soc Trans. 1995 Aug; 23(3):479S. Abbott GW, Mercer EA, Wolters M, Sewing S, Pongs O, Srai SK. PMID: 8566376.
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    137. Structural characterisation of a slowly activating potassium channel (IsK). Biochem Soc Trans. 1995 Aug; 23(3):478S. Mercer EA, Abbott GW, Ramesh B, Haris PI, Chapman D, Srai SK. PMID: 8566375.
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