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Geoffrey Winston Abbott

Title(s)Professor, Physiology And Biophysics
Phone(949) 824-3269
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    Collapse Research 
    Collapse Research Activities and Funding
    GABA activation of the M-current
    NIH/NINDS R01NS107671Mar 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Ion Channel Transporter Interactions
    NIH/NIGMS R35GM130377Feb 1, 2019 - Jan 31, 2024
    Role: Principal Investigator
    Discovering the function of a putative ion channel family linked to inherited diseases
    NIH/NIDCD R21DC015982Mar 1, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Real-time potassium channel subunit dynamics
    NIH/NIDCD R21DC015736Sep 20, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Ion channel-transporter interactions
    NIH/NIGMS R01GM115189Apr 1, 2015 - Jan 31, 2019
    Role: Principal Investigator
    FASEB SRC on Ion Channel Regulation
    NIH/NINDS R13NS083143Jun 1, 2013 - May 31, 2014
    Role: Principal Investigator
    Predictive multiscale modeling of atrial fibrillation for therapy development
    NIH/NHLBI R01HL101190Apr 12, 2010 - Mar 31, 2014
    Role: Co-Principal Investigator
    Molecular Characterization of the Sodium/Iodide Symporter (NIS)
    NIH/NIDDK R01DK041544Dec 3, 2009 - May 21, 2012
    Role: Co-Principal Investigator
    K+ Channel Trafficking and Modulation by Mink and MiRP1
    NIH/NHLBI R01HL079275Dec 15, 2004 - Sep 30, 2011
    Role: Principal Investigator
    Regulation of Kv3.1 by MiRPs in Auditory Neurons
    NIH/NIDCD R03DC007060Jul 1, 2004 - Jun 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. van der Horst J, Manville RW, Hayes K, Thomsen MB, Abbott GW, Jepps TA. Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly. Arterioscler Thromb Vasc Biol. 2020 Mar 19; ATVBAHA120313997. PMID: 32188278.
      View in: PubMed
    2. Manville RW, Abbott GW. Potassium channels act as chemosensors for solute transporters. Commun Biol. 2020 Feb 28; 3(1):90. PMID: 32111967.
      View in: PubMed
    3. Manville RW, Papanikolaou M, Abbott GW. M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body ß-Hydroxybutyrate. J Pharmacol Exp Ther. 2020 Feb; 372(2):148-156. PMID: 31757819.
      View in: PubMed
    4. Manville RW, Abbott GW. In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner. Commun Biol. 2019; 2:401. PMID: 31701029.
      View in: PubMed
    5. Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW. KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines. Proc Natl Acad Sci U S A. 2019 Oct 15; 116(42):21236-21245. PMID: 31570602.
      View in: PubMed
    6. Vawter MP, Hamzeh AR, Muradyan E, Civelli O, Abbott GW, Alachkar A. Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies. Mol Neuropsychiatry. 2019 Oct; 5(4):200-211. PMID: 31768373.
      View in: PubMed
    7. Manville RW, Abbott GW. Cilantro leaf harbors a potent potassium channel-activating anticonvulsant. FASEB J. 2019 Oct; 33(10):11349-11363. PMID: 31311306.
      View in: PubMed
    8. Zhou L, Köhncke C, Hu Z, Roepke TK, Abbott GW. The KCNE2 potassium channel ß subunit is required for normal lung function and resilience to ischemia and reperfusion injury. FASEB J. 2019 Sep; 33(9):9762-9774. PMID: 31162977.
      View in: PubMed
    9. Manville RW, Abbott GW. Teamwork: Ion channels and transporters join forces in the brain. Neuropharmacology. 2019 12 15; 161:107601. PMID: 30959022.
      View in: PubMed
    10. Hu Z, Jepps TA, Zhou L, Liu J, Li M, Abbott GW. Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice. Am J Physiol Regul Integr Comp Physiol. 2019 05 01; 316(5):R552-R562. PMID: 30758982.
      View in: PubMed
    11. Hu Z, Liu J, Zhou L, Tian X, Abbott GW. AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death. Physiol Rep. 2019 02; 7(3):e13957. PMID: 30737904.
      View in: PubMed
    12. Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW. KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity. J Cell Physiol. 2019 Aug; 234(8):13361-13369. PMID: 30613966.
      View in: PubMed
    13. De Silva AM, Manville RW, Abbott GW. Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. Sci Adv. 2018 11; 4(11):eaav0824. PMID: 30443601.
      View in: PubMed
    14. David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW. Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia. FASEB J. 2019 02; 33(2):2537-2552. PMID: 30289750.
      View in: PubMed
    15. Manville RW, Abbott GW. Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket. Nat Commun. 2018 09 21; 9(1):3845. PMID: 30242262.
      View in: PubMed
    16. Manville RW, Abbott GW. Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels. Mol Pharmacol. 2018 10; 94(4):1155-1163. PMID: 30021858.
      View in: PubMed
    17. Hu Z, Wei W, Zhou L, Chen M, Abbott GW. Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. Sci Rep. 2018 05 29; 8(1):8258. PMID: 29844497.
      View in: PubMed
    18. Luo N, Liu J, Chen Y, Li H, Hu Z, Abbott GW. Remote ischemic preconditioning STAT3-dependently ameliorates pulmonary ischemia/reperfusion injury. PLoS One. 2018; 13(5):e0196186. PMID: 29768493.
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    19. Manville RW, Papanikolaou M, Abbott GW. Direct neurotransmitter activation of voltage-gated potassium channels. Nat Commun. 2018 05 10; 9(1):1847. PMID: 29748663.
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    20. Abbott GW. ß Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation. Front Physiol. 2017; 8:646. PMID: 28919864.
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    21. Alachkar A, Wang L, Yoshimura R, Hamzeh AR, Wang Z, Sanathara N, Lee SM, Xu X, Abbott GW, Civelli O. Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Mol Psychiatry. 2018 02; 23(2):282-294. PMID: 28809400.
      View in: PubMed
    22. Manville RW, Neverisky DL, Abbott GW. SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore. Biophys J. 2017 Aug 08; 113(3):613-626. PMID: 28793216.
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    23. Abbott GW. Chansporter complexes in cell signaling. FEBS Lett. 2017 09; 591(17):2556-2576. PMID: 28718502.
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    24. Hu Z, Chen M, Zhang P, Liu J, Abbott GW. Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats. Cardiovasc Diabetol. 2017 04 26; 16(1):57. PMID: 28446231.
      View in: PubMed
    25. King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW. Targeted deletion of Kcne3 impairs skeletal muscle function in mice. FASEB J. 2017 07; 31(7):2937-2947. PMID: 28356343.
      View in: PubMed
    26. Neverisky DL, Abbott GW. KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. FASEB J. 2017 07; 31(7):2828-2838. PMID: 28283543.
      View in: PubMed
    27. Lee SM, Baik J, Nguyen D, Nguyen V, Liu S, Hu Z, Abbott GW. Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus. FASEB J. 2017 06; 31(6):2674-2685. PMID: 28280005.
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    28. Abbott GW. ß Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants. Front Physiol. 2017; 8:66. PMID: 28228734.
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    29. Yang S, Abbott GW, Gao WD, Liu J, Luo C, Hu Z. Involvement of glycogen synthase kinase-3ß in liver ischemic conditioning induced cardioprotection against myocardial ischemia and reperfusion injury in rats. J Appl Physiol (1985). 2017 May 01; 122(5):1095-1105. PMID: 28153944.
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    30. Abbott GW. Correction: Channel-transporter complexes: an emerging theme in cell signalling. Biochem J. 2016 12 15; 473(24):4714. PMID: 27941032.
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    31. Abbott GW. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. Sci Rep. 2016 12 06; 6:38412. PMID: 27922120.
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    32. Abbott GW. Channel-transporter complexes: an emerging theme in cell signaling. Biochem J. 2016 11 01; 473(21):3759-3763. PMID: 27789743.
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    33. Hu Z, Hu S, Yang S, Chen M, Zhang P, Liu J, Abbott GW. Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3ß-Dependent Mechanism. PLoS One. 2016; 11(10):e0165123. PMID: 27768739.
      View in: PubMed
    34. Abbott GW, Jepps TA. Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity. J Vasc Res. 2016; 53(3-4):138-148. PMID: 27710966.
      View in: PubMed
    35. Abbott GW. KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis. Gene. 2016 Nov 30; 593(2):249-60. PMID: 27484720.
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    36. Abbott GW. Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4. FASEB J. 2016 08; 30(8):2959-69. PMID: 27162025.
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    37. Neverisky DL, Abbott GW. Ion channel-transporter interactions. Crit Rev Biochem Mol Biol. 2015 Jul-Aug; 51(4):257-67. PMID: 27098917.
      View in: PubMed
    38. Abbott GW, Roepke TK. KCNE2 and gastric cancer: bench to bedside. Oncotarget. 2016 Apr 05; 7(14):17286-7. PMID: 26956055.
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    39. Lee SM, Nguyen D, Anand M, Kant R, Köhncke C, Lisewski U, Roepke TK, Hu Z, Abbott GW. Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia. Sci Rep. 2016 Mar 17; 6:23118. PMID: 26984260.
      View in: PubMed
    40. Hu Z, Crump SM, Zhang P, Abbott GW. Kcne2 deletion attenuates acute post-ischaemia/reperfusion myocardial infarction. Cardiovasc Res. 2016 May 15; 110(2):227-37. PMID: 26952045.
      View in: PubMed
    41. Abbott GW. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene. 2016 Jan 15; 576(1 Pt 1):1-13. PMID: 26410412.
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    42. Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice. FASEB J. 2016 Jan; 30(1):360-9. PMID: 26399785.
      View in: PubMed
    43. Abbott GW. Pharmacogenetic diversification by alternative translation initiation: background channels to the fore: Commentary on Kisselbach et?al., Br J Pharmacol 171: 5182-5194. Br J Pharmacol. 2015 Sep; 172(18):4591-4593. PMID: 24528336.
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    44. Lee SM, Nguyen D, Hu Z, Abbott GW. Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death. J Mol Cell Cardiol. 2015 Oct; 87:148-51. PMID: 26307149.
      View in: PubMed
    45. Abbott GW. The KCNE2 K? channel regulatory subunit: Ubiquitous influence, complex pathobiology. Gene. 2015 Sep 15; 569(2):162-72. PMID: 26123744.
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    46. Abbott GW, Pitt GS. Ion channels under the sun. FASEB J. 2014 May; 28(5):1957-62. PMID: 24786286.
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    47. Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT. KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Sci Signal. 2014 Mar 04; 7(315):ra22. PMID: 24595108.
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    48. Crump SM, Abbott GW. Arrhythmogenic KCNE gene variants: current knowledge and future challenges. Front Genet. 2014; 5:3. PMID: 24478792.
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    49. Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014 Feb 28; 289(9):5889-903. PMID: 24403084.
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    50. Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW. Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death. Circ Cardiovasc Genet. 2014 Feb; 7(1):33-42. PMID: 24403551.
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    51. Kant R, Hu Z, Malhotra JK, Krogh-Madsen T, Christini DJ, Heerdt PM, Abbott GW. NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS One. 2013; 8(12):e82951. PMID: 24376615.
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    52. Hu Z, Crump SM, Anand M, Kant R, Levi R, Abbott GW. Kcne3 deletion initiates extracardiac arrhythmogenesis in mice. FASEB J. 2014 Feb; 28(2):935-45. PMID: 24225147.
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    53. Hu ZY, Abbott GW, Fang YD, Huang YS, Liu J. Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. J Physiol Sci. 2013 Jul; 63(4):251-61. PMID: 23625523.
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    54. Abbott GW. KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing? Expert Rev Clin Pharmacol. 2013 Jan; 6(1):49-60. PMID: 23272793.
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    55. Abbott GW, Ramesh B, Srai SK. Interaction between soluble and membrane-embedded potassium channel peptides monitored by Fourier transform infrared spectroscopy. PLoS One. 2012; 7(11):e49070. PMID: 23145073.
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    56. Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA. Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One. 2012; 7(8):e42756. PMID: 22880098.
      View in: PubMed
    57. Kanda VA, Abbott GW. KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task? Front Physiol. 2012; 3:231. PMID: 22754540.
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    58. Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW. Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. J Mol Cell Cardiol. 2012 Sep; 53(3):350-3. PMID: 22641150.
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    59. Purtell K, Paroder-Belenitsky M, Reyna-Neyra A, Nicola JP, Koba W, Fine E, Carrasco N, Abbott GW. The KCNQ1-KCNE2 K? channel is required for adequate thyroid I? uptake. FASEB J. 2012 Aug; 26(8):3252-9. PMID: 22549510.
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    60. Krogh-Madsen T, Abbott GW, Christini DJ. Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS Comput Biol. 2012; 8(2):e1002390. PMID: 22383869.
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    61. Abbott GW. KCNE2 and the K (+) channel: the tail wagging the dog. Channels (Austin). 2012 Jan-Feb; 6(1):1-10. PMID: 22513486.
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    62. Kanda VA, Lewis A, Xu X, Abbott GW. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Biophys J. 2011 Sep 21; 101(6):1354-63. PMID: 21943416.
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    63. Kanda VA, Lewis A, Xu X, Abbott GW. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Biophys J. 2011 Sep 21; 101(6):1364-75. PMID: 21943417.
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    64. Roepke TK, Kanda VA, Purtell K, King EC, Lerner DJ, Abbott GW. KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec; 25(12):4264-73. PMID: 21859894.
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    65. Kanda VA, Purtell K, Abbott GW. Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Heart Rhythm. 2011 Oct; 8(10):1641-7. PMID: 21699843.
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    66. Roepke TK, King EC, Purtell K, Kanda VA, Lerner DJ, Abbott GW. Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 2011 Feb; 25(2):727-36. PMID: 21084694.
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    67. Purtell K, Roepke TK, Abbott GW. Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. Int J Biochem Cell Biol. 2010 Nov; 42(11):1767-70. PMID: 20688187.
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    68. Harkcom WT, Abbott GW. Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Rev Cardiovasc Ther. 2010 Aug; 8(8):1161-73. PMID: 20670193.
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    69. Roepke TK, Purtell K, King EC, La Perle KM, Lerner DJ, Abbott GW. Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One. 2010 Jul 06; 5(7):e11451. PMID: 20625512.
      View in: PubMed
    70. Choi E, Abbott GW. A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor. FASEB J. 2010 May; 24(5):1518-24. PMID: 20040519.
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    71. Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nat Med. 2009 Oct; 15(10):1186-94. PMID: 19767733.
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    72. Gaeta SA, Bub G, Abbott GW, Christini DJ. Dynamical mechanism for subcellular alternans in cardiac myocytes. Circ Res. 2009 Aug 14; 105(4):335-42. PMID: 19628792.
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    73. Abbott GW, Roepke TK. HERG biosynthesis: the positive influence of negative charge. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1211-2. PMID: 19286960.
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    74. McCrossan ZA, Roepke TK, Lewis A, Panaghie G, Abbott GW. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J Membr Biol. 2009 Mar; 228(1):1-14. PMID: 19219384.
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    75. Xu X, Kanda VA, Choi E, Panaghie G, Roepke TK, Gaeta SA, Christini DJ, Lerner DJ, Abbott GW. MinK-dependent internalization of the IKs potassium channel. Cardiovasc Res. 2009 Jun 01; 82(3):430-8. PMID: 19202166.
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    76. Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB J. 2008 Oct; 22(10):3648-60. PMID: 18603586.
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    77. Panaghie G, Purtell K, Tai KK, Abbott GW. Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophys J. 2008 Sep 15; 95(6):2759-78. PMID: 18567635.
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    78. Morrey C, Estephan R, Abbott GW, Levi R. Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels. J Pharmacol Exp Ther. 2008 Sep; 326(3):871-8. PMID: 18523159.
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    79. Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008 May 22; 453(7194):524-8. PMID: 18432194.
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    80. Abbott GW, Roepke TK. Pharmacogenetics of drug-induced arrhythmias. Expert Rev Clin Pharmacol. 2008 Jan; 1(1):93-104. PMID: 24410513.
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    81. Abbott GW, Ramesh B, Srai SK. Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. Protein Pept Lett. 2008; 15(1):63-75. PMID: 18221016.
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    82. Abbott GW, Xu X, Roepke TK. Impact of ancillary subunits on ventricular repolarization. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S42-6. PMID: 17993327.
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    83. Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, Abbott GW. A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovasc Res. 2008 Jan; 77(1):98-106. PMID: 18006462.
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    84. Choi E, Abbott GW. The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease. Mol Pharmacol. 2007 Sep; 72(3):499-501. PMID: 17595326.
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    85. Panaghie G, Abbott GW. The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J Gen Physiol. 2007 Feb; 129(2):121-33. PMID: 17227916.
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    86. Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem. 2006 Aug 18; 281(33):23740-7. PMID: 16754665.
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    87. Abbott GW, Butler MH, Goldstein SA. Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. FASEB J. 2006 Feb; 20(2):293-301. PMID: 16449802.
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    88. Panaghie G, Abbott GW. The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Curr Pharm Des. 2006; 12(18):2285-302. PMID: 16787255.
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    89. Abbott GW. Molecular mechanisms of cardiac voltage-gated potassium channelopathies. Curr Pharm Des. 2006; 12(28):3631-44. PMID: 17073664.
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    90. Roepke TK, Abbott GW. Pharmacogenetics and cardiac ion channels. Vascul Pharmacol. 2006 Feb; 44(2):90-106. PMID: 16344000.
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    91. Gordon E, Roepke TK, Abbott GW. Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies. Biophys J. 2006 Feb 15; 90(4):1223-31. PMID: 16326911.
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    92. Gordon E, Cohen JL, Engel R, Abbott GW. 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar; 69(3):718-26. PMID: 16317109.
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    93. Panaghie G, Tai KK, Abbott GW. Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol. 2006 Feb 01; 570(Pt 3):455-67. PMID: 16308347.
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    94. Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther. 2005 Nov; 315(2):517-25. PMID: 16033909.
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    95. Anantharam A, Abbott GW. Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1. Novartis Found Symp. 2005; 266:100-12; discussion 112-7, 155-8. PMID: 16050264.
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    96. McCrossan ZA, Abbott GW. The MinK-related peptides. Neuropharmacology. 2004 Nov; 47(6):787-821. PMID: 15527815.
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    97. Lewis A, McCrossan ZA, Abbott GW. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J Biol Chem. 2004 Feb 27; 279(9):7884-92. PMID: 14679187.
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    98. Anantharam A, Markowitz SM, Abbott GW. Pharmacogenetic considerations in diseases of cardiac ion channels. J Pharmacol Exp Ther. 2003 Dec; 307(3):831-8. PMID: 14561846.
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    99. McCrossan ZA, Lewis A, Panaghie G, Jordan PN, Christini DJ, Lerner DJ, Abbott GW. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci. 2003 Sep 03; 23(22):8077-91. PMID: 12954870.
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    100. Tai KK, McCrossan ZA, Abbott GW. Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. J Neurochem. 2003 Mar; 84(5):1193-200. PMID: 12603842.
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    101. Anantharam A, Lewis A, Panaghie G, Gordon E, McCrossan ZA, Lerner DJ, Abbott GW. RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. J Biol Chem. 2003 Apr 04; 278(14):11739-45. PMID: 12529362.
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    102. Abbott GW, Goldstein SA. Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB J. 2002 Mar; 16(3):390-400. PMID: 11874988.
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    103. Abbott GW, Goldstein SA. Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). Mol Interv. 2001 Jun; 1(2):95-107. PMID: 14993329.
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    104. Abbott GW, Goldstein SA, Sesti F. Do all voltage-gated potassium channels use MiRPs? Circ Res. 2001 May 25; 88(10):981-3. PMID: 11375265.
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    107. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16; 97(2):175-87. PMID: 10219239.
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    108. Abbott GW, Goldstein SA. A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q Rev Biophys. 1998 Nov; 31(4):357-98. PMID: 10709243.
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    110. Abbott GW, Bloemendal M, Van Stokkum IH, Mercer EA, Miller RT, Sewing S, Wolters M, Pongs O, Srai SK. Secondary structure, stability and tetramerisation of recombinant K(V)1.1 potassium channel cytoplasmic N-terminal fragment. Biochim Biophys Acta. 1997 Aug 15; 1341(1):71-8. PMID: 9300810.
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    112. Abbott GW, Mercer EA, Wolters M, Sewing S, Pongs O, Srai SK. Structure analysis of a recombinant voltage-gated potassium channel (Kv1.1) N-terminus using FTIR spectroscopy and thermal denaturation. Biochem Soc Trans. 1995 Aug; 23(3):479S. PMID: 8566376.
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    113. Mercer EA, Abbott GW, Ramesh B, Haris PI, Chapman D, Srai SK. Structural characterisation of a slowly activating potassium channel (IsK). Biochem Soc Trans. 1995 Aug; 23(3):478S. PMID: 8566375.
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