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Abbott, Geoffrey Winston

Title(s)Professor, Physiology and Biophysics
Phone(949) 824-3269
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    Collapse Research 
    Collapse Research Activities and Funding
    Discovering the function of a putative ion channel family linked to inherited diseases
    NIH/NIDCD R21DC015982Mar 1, 2017 - Feb 28, 2019
    Role: Principal Investigator
    Real-time potassium channel subunit dynamics
    NIH/NIDCD R21DC015736Sep 20, 2016 - Aug 31, 2018
    Role: Principal Investigator
    Ion channel-transporter interactions
    NIH/NIGMS R01GM115189Apr 1, 2015 - Jan 31, 2019
    Role: Principal Investigator
    FASEB SRC on Ion Channel Regulation
    NIH/NINDS R13NS083143Jun 1, 2013 - May 31, 2014
    Role: Principal Investigator
    Predictive multiscale modeling of atrial fibrillation for therapy development
    NIH/NHLBI R01HL101190Apr 12, 2010 - Mar 31, 2014
    Role: Co-Principal Investigator
    K+ Channel Trafficking and Modulation by Mink and MiRP1
    NIH/NHLBI R01HL079275Dec 15, 2004 - Apr 30, 2016
    Role: Principal Investigator
    Regulation of Kv3.1 by MiRPs in Auditory Neurons
    NIH/NIDCD R03DC007060Jul 1, 2004 - Jun 30, 2007
    Role: Principal Investigator
    Molecular Characterization of the Sodium/Iodide Symporter (NIS)
    NIH/NIDDK R01DK041544May 1, 1989 - Jul 31, 2018
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW. KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity. J Cell Physiol. 2019 Jan 05. PMID: 30613966.
      View in: PubMed
    2. De Silva AM, Manville RW, Abbott GW. Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. Sci Adv. 2018 Nov; 4(11):eaav0824. PMID: 30443601.
      View in: PubMed
    3. David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW. Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia. FASEB J. 2018 Oct 05; fj201800502R. PMID: 30289750.
      View in: PubMed
    4. Manville RW, Abbott GW. Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket. Nat Commun. 2018 09 21; 9(1):3845. PMID: 30242262.
      View in: PubMed
    5. Manville RW, Abbott GW. Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels. Mol Pharmacol. 2018 Oct; 94(4):1155-1163. PMID: 30021858.
      View in: PubMed
    6. Hu Z, Wei W, Zhou L, Chen M, Abbott GW. Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. Sci Rep. 2018 May 29; 8(1):8258. PMID: 29844497.
      View in: PubMed
    7. Luo N, Liu J, Chen Y, Li H, Hu Z, Abbott GW. Remote ischemic preconditioning STAT3-dependently ameliorates pulmonary ischemia/reperfusion injury. PLoS One. 2018; 13(5):e0196186. PMID: 29768493.
      View in: PubMed
    8. Manville RW, Papanikolaou M, Abbott GW. Direct neurotransmitter activation of voltage-gated potassium channels. Nat Commun. 2018 05 10; 9(1):1847. PMID: 29748663.
      View in: PubMed
    9. Abbott GW. ß Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation. Front Physiol. 2017; 8:646. PMID: 28919864.
      View in: PubMed
    10. Manville RW, Neverisky DL, Abbott GW. SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore. Biophys J. 2017 Aug 08; 113(3):613-626. PMID: 28793216.
      View in: PubMed
    11. Abbott GW. Chansporter complexes in cell signaling. FEBS Lett. 2017 09; 591(17):2556-2576. PMID: 28718502.
      View in: PubMed
    12. Hu Z, Chen M, Zhang P, Liu J, Abbott GW. Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats. Cardiovasc Diabetol. 2017 04 26; 16(1):57. PMID: 28446231.
      View in: PubMed
    13. King EC, Patel V, Anand M, Zhao X, Crump SM, Hu Z, Weisleder N, Abbott GW. Targeted deletion of Kcne3 impairs skeletal muscle function in mice. FASEB J. 2017 07; 31(7):2937-2947. PMID: 28356343.
      View in: PubMed
    14. Neverisky DL, Abbott GW. KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. FASEB J. 2017 07; 31(7):2828-2838. PMID: 28283543.
      View in: PubMed
    15. Lee SM, Baik J, Nguyen D, Nguyen V, Liu S, Hu Z, Abbott GW. Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus. FASEB J. 2017 06; 31(6):2674-2685. PMID: 28280005.
      View in: PubMed
    16. Abbott GW. ß Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants. Front Physiol. 2017; 8:66. PMID: 28228734.
      View in: PubMed
    17. Yang S, Abbott GW, Gao WD, Liu J, Luo C, Hu Z. Involvement of glycogen synthase kinase-3ß in liver ischemic conditioning induced cardioprotection against myocardial ischemia and reperfusion injury in rats. J Appl Physiol (1985). 2017 May 01; 122(5):1095-1105. PMID: 28153944.
      View in: PubMed
    18. Abbott GW. Correction: Channel-transporter complexes: an emerging theme in cell signalling. Biochem J. 2016 12 15; 473(24):4714. PMID: 27941032.
      View in: PubMed
    19. Abbott GW. Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. Sci Rep. 2016 12 06; 6:38412. PMID: 27922120.
      View in: PubMed
    20. Abbott GW. Channel-transporter complexes: an emerging theme in cell signaling. Biochem J. 2016 11 01; 473(21):3759-3763. PMID: 27789743.
      View in: PubMed
    21. Hu Z, Hu S, Yang S, Chen M, Zhang P, Liu J, Abbott GW. Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3ß-Dependent Mechanism. PLoS One. 2016; 11(10):e0165123. PMID: 27768739.
      View in: PubMed
    22. Abbott GW, Jepps TA. Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity. J Vasc Res. 2016; 53(3-4):138-148. PMID: 27710966.
      View in: PubMed
    23. Abbott GW. KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis. Gene. 2016 Nov 30; 593(2):249-60. PMID: 27484720.
      View in: PubMed
    24. Abbott GW. Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4. FASEB J. 2016 08; 30(8):2959-69. PMID: 27162025.
      View in: PubMed
    25. Neverisky DL, Abbott GW. Ion channel-transporter interactions. Crit Rev Biochem Mol Biol. 2015 Jul-Aug; 51(4):257-67. PMID: 27098917.
      View in: PubMed
    26. Abbott GW, Roepke TK. KCNE2 and gastric cancer: bench to bedside. Oncotarget. 2016 Apr 05; 7(14):17286-7. PMID: 26956055; PMCID: PMC4951210.
      View in: PubMed, PubMed Central
    27. Lee SM, Nguyen D, Anand M, Kant R, Köhncke C, Lisewski U, Roepke TK, Hu Z, Abbott GW. Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia. Sci Rep. 2016 Mar 17; 6:23118. PMID: 26984260; PMCID: PMC4794722.
      View in: PubMed, PubMed Central
    28. Hu Z, Crump SM, Zhang P, Abbott GW. Kcne2 deletion attenuates acute post-ischaemia/reperfusion myocardial infarction. Cardiovasc Res. 2016 May 15; 110(2):227-37. PMID: 26952045; PMCID: PMC4836628 [Available on 05/15/17].
      View in: PubMed, PubMed Central
    29. Abbott GW. KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene. 2016 Jan 15; 576(1 Pt 1):1-13. PMID: 26410412; PMCID: PMC4917010 [Available on 01/15/17].
      View in: PubMed, PubMed Central
    30. Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice. FASEB J. 2016 Jan; 30(1):360-9. PMID: 26399785; PMCID: PMC4684512 [Available on 01/01/17].
      View in: PubMed, PubMed Central
    31. Lee SM, Nguyen D, Hu Z, Abbott GW. Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death. J Mol Cell Cardiol. 2015 Oct; 87:148-51. PMID: 26307149.
      View in: PubMed
    32. Abbott GW. The KCNE2 K? channel regulatory subunit: Ubiquitous influence, complex pathobiology. Gene. 2015 Sep 15; 569(2):162-72. PMID: 26123744; PMCID: PMC4917011.
      View in: PubMed, PubMed Central
    33. Abbott GW, Pitt GS. Ion channels under the sun. FASEB J. 2014 May; 28(5):1957-62. PMID: 24786286; PMCID: PMC3986833.
      View in: PubMed, PubMed Central
    34. Abbott GW, Tai KK, Neverisky DL, Hansler A, Hu Z, Roepke TK, Lerner DJ, Chen Q, Liu L, Zupan B, Toth M, Haynes R, Huang X, Demirbas D, Buccafusca R, Gross SS, Kanda VA, Berry GT. KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Sci Signal. 2014 Mar 04; 7(315):ra22. PMID: 24595108; PMCID: PMC4063528.
      View in: PubMed, PubMed Central
    35. Crump SM, Abbott GW. Arrhythmogenic KCNE gene variants: current knowledge and future challenges. Front Genet. 2014; 5:3. PMID: 24478792; PMCID: PMC3900874.
      View in: PubMed, PubMed Central
    36. Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014 Feb 28; 289(9):5889-903. PMID: 24403084; PMCID: PMC3937658.
      View in: PubMed, PubMed Central
    37. Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW. Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death. Circ Cardiovasc Genet. 2014 Feb; 7(1):33-42. PMID: 24403551; PMCID: PMC4917016.
      View in: PubMed, PubMed Central
    38. Kant R, Hu Z, Malhotra JK, Krogh-Madsen T, Christini DJ, Heerdt PM, Abbott GW. NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS One. 2013; 8(12):e82951. PMID: 24376615; PMCID: PMC3871617.
      View in: PubMed, PubMed Central
    39. Hu Z, Crump SM, Anand M, Kant R, Levi R, Abbott GW. Kcne3 deletion initiates extracardiac arrhythmogenesis in mice. FASEB J. 2014 Feb; 28(2):935-45. PMID: 24225147; PMCID: PMC3898654.
      View in: PubMed, PubMed Central
    40. Hu ZY, Abbott GW, Fang YD, Huang YS, Liu J. Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. J Physiol Sci. 2013 Jul; 63(4):251-61. PMID: 23625523.
      View in: PubMed
    41. Abbott GW. KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing? Expert Rev Clin Pharmacol. 2013 Jan; 6(1):49-60. PMID: 23272793; PMCID: PMC4917007.
      View in: PubMed, PubMed Central
    42. Abbott GW, Ramesh B, Srai SK. Interaction between soluble and membrane-embedded potassium channel peptides monitored by Fourier transform infrared spectroscopy. PLoS One. 2012; 7(11):e49070. PMID: 23145073; PMCID: PMC3493504.
      View in: PubMed, PubMed Central
    43. Ying SW, Kanda VA, Hu Z, Purtell K, King EC, Abbott GW, Goldstein PA. Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One. 2012; 7(8):e42756. PMID: 22880098; PMCID: PMC3411840.
      View in: PubMed, PubMed Central
    44. Kanda VA, Abbott GW. KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task? Front Physiol. 2012; 3:231. PMID: 22754540; PMCID: PMC3385356.
      View in: PubMed, PubMed Central
    45. Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW. Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. J Mol Cell Cardiol. 2012 Sep; 53(3):350-3. PMID: 22641150; PMCID: PMC3418454.
      View in: PubMed, PubMed Central
    46. Purtell K, Paroder-Belenitsky M, Reyna-Neyra A, Nicola JP, Koba W, Fine E, Carrasco N, Abbott GW. The KCNQ1-KCNE2 K? channel is required for adequate thyroid I? uptake. FASEB J. 2012 Aug; 26(8):3252-9. PMID: 22549510; PMCID: PMC3405278.
      View in: PubMed, PubMed Central
    47. Krogh-Madsen T, Abbott GW, Christini DJ. Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS Comput Biol. 2012; 8(2):e1002390. PMID: 22383869; PMCID: PMC3285569.
      View in: PubMed, PubMed Central
    48. Abbott GW. KCNE2 and the K (+) channel: the tail wagging the dog. Channels (Austin). 2012 Jan-Feb; 6(1):1-10. PMID: 22513486; PMCID: PMC3367673.
      View in: PubMed, PubMed Central
    49. Kanda VA, Lewis A, Xu X, Abbott GW. KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Biophys J. 2011 Sep 21; 101(6):1354-63. PMID: 21943416; PMCID: PMC3177047.
      View in: PubMed, PubMed Central
    50. Kanda VA, Lewis A, Xu X, Abbott GW. KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Biophys J. 2011 Sep 21; 101(6):1364-75. PMID: 21943417; PMCID: PMC3177048.
      View in: PubMed, PubMed Central
    51. Roepke TK, Kanda VA, Purtell K, King EC, Lerner DJ, Abbott GW. KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec; 25(12):4264-73. PMID: 21859894; PMCID: PMC3236621.
      View in: PubMed, PubMed Central
    52. Kanda VA, Purtell K, Abbott GW. Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Heart Rhythm. 2011 Oct; 8(10):1641-7. PMID: 21699843; PMCID: PMC3183296.
      View in: PubMed, PubMed Central
    53. Roepke TK, King EC, Purtell K, Kanda VA, Lerner DJ, Abbott GW. Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 2011 Feb; 25(2):727-36. PMID: 21084694; PMCID: PMC3023397.
      View in: PubMed, PubMed Central
    54. Purtell K, Roepke TK, Abbott GW. Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. Int J Biochem Cell Biol. 2010 Nov; 42(11):1767-70. PMID: 20688187; PMCID: PMC2950229.
      View in: PubMed, PubMed Central
    55. Harkcom WT, Abbott GW. Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Rev Cardiovasc Ther. 2010 Aug; 8(8):1161-73. PMID: 20670193; PMCID: PMC2921896.
      View in: PubMed, PubMed Central
    56. Roepke TK, Purtell K, King EC, La Perle KM, Lerner DJ, Abbott GW. Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One. 2010 Jul 06; 5(7):e11451. PMID: 20625512; PMCID: PMC2897890.
      View in: PubMed, PubMed Central
    57. Choi E, Abbott GW. A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor. FASEB J. 2010 May; 24(5):1518-24. PMID: 20040519; PMCID: PMC2879946.
      View in: PubMed, PubMed Central
    58. Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW. Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nat Med. 2009 Oct; 15(10):1186-94. PMID: 19767733; PMCID: PMC2790327.
      View in: PubMed, PubMed Central
    59. Gaeta SA, Bub G, Abbott GW, Christini DJ. Dynamical mechanism for subcellular alternans in cardiac myocytes. Circ Res. 2009 Aug 14; 105(4):335-42. PMID: 19628792; PMCID: PMC2740370.
      View in: PubMed, PubMed Central
    60. Abbott GW, Roepke TK. HERG biosynthesis: the positive influence of negative charge. Am J Physiol Heart Circ Physiol. 2009 May; 296(5):H1211-2. PMID: 19286960; PMCID: PMC2685362.
      View in: PubMed, PubMed Central
    61. McCrossan ZA, Roepke TK, Lewis A, Panaghie G, Abbott GW. Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J Membr Biol. 2009 Mar; 228(1):1-14. PMID: 19219384; PMCID: PMC2849987.
      View in: PubMed, PubMed Central
    62. Xu X, Kanda VA, Choi E, Panaghie G, Roepke TK, Gaeta SA, Christini DJ, Lerner DJ, Abbott GW. MinK-dependent internalization of the IKs potassium channel. Cardiovasc Res. 2009 Jun 01; 82(3):430-8. PMID: 19202166; PMCID: PMC2682613.
      View in: PubMed, PubMed Central
    63. Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB J. 2008 Oct; 22(10):3648-60. PMID: 18603586; PMCID: PMC2537427.
      View in: PubMed, PubMed Central
    64. Panaghie G, Purtell K, Tai KK, Abbott GW. Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophys J. 2008 Sep 15; 95(6):2759-78. PMID: 18567635; PMCID: PMC2527255.
      View in: PubMed, PubMed Central
    65. Morrey C, Estephan R, Abbott GW, Levi R. Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels. J Pharmacol Exp Ther. 2008 Sep; 326(3):871-8. PMID: 18523159; PMCID: PMC2577049.
      View in: PubMed, PubMed Central
    66. Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008 May 22; 453(7194):524-8. PMID: 18432194.
      View in: PubMed
    67. Abbott GW, Roepke TK. Pharmacogenetics of drug-induced arrhythmias. Expert Rev Clin Pharmacol. 2008 Jan; 1(1):93-104. PMID: 24410513.
      View in: PubMed
    68. Abbott GW, Xu X, Roepke TK. Impact of ancillary subunits on ventricular repolarization. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S42-6. PMID: 17993327; PMCID: PMC2128763.
      View in: PubMed, PubMed Central
    69. Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, Abbott GW. A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovasc Res. 2008 Jan; 77(1):98-106. PMID: 18006462.
      View in: PubMed
    70. Choi E, Abbott GW. The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease. Mol Pharmacol. 2007 Sep; 72(3):499-501. PMID: 17595326.
      View in: PubMed
    71. Panaghie G, Abbott GW. The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J Gen Physiol. 2007 Feb; 129(2):121-33. PMID: 17227916; PMCID: PMC2154355.
      View in: PubMed, PubMed Central
    72. Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem. 2006 Aug 18; 281(33):23740-7. PMID: 16754665.
      View in: PubMed
    73. Abbott GW, Butler MH, Goldstein SA. Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. FASEB J. 2006 Feb; 20(2):293-301. PMID: 16449802.
      View in: PubMed
    74. Panaghie G, Abbott GW. The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Curr Pharm Des. 2006; 12(18):2285-302. PMID: 16787255.
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    75. Abbott GW. Molecular mechanisms of cardiac voltage-gated potassium channelopathies. Curr Pharm Des. 2006; 12(28):3631-44. PMID: 17073664.
      View in: PubMed
    76. Roepke TK, Abbott GW. Pharmacogenetics and cardiac ion channels. Vascul Pharmacol. 2006 Feb; 44(2):90-106. PMID: 16344000.
      View in: PubMed
    77. Gordon E, Roepke TK, Abbott GW. Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies. Biophys J. 2006 Feb 15; 90(4):1223-31. PMID: 16326911; PMCID: PMC1367273.
      View in: PubMed, PubMed Central
    78. Gordon E, Cohen JL, Engel R, Abbott GW. 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar; 69(3):718-26. PMID: 16317109.
      View in: PubMed
    79. Panaghie G, Tai KK, Abbott GW. Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol. 2006 Feb 01; 570(Pt 3):455-67. PMID: 16308347; PMCID: PMC1479883.
      View in: PubMed, PubMed Central
    80. Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther. 2005 Nov; 315(2):517-25. PMID: 16033909.
      View in: PubMed
    81. Anantharam A, Abbott GW. Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1. Novartis Found Symp. 2005; 266:100-12; discussion 112-7, 155-8. PMID: 16050264.
      View in: PubMed
    82. McCrossan ZA, Abbott GW. The MinK-related peptides. Neuropharmacology. 2004 Nov; 47(6):787-821. PMID: 15527815.
      View in: PubMed
    83. Lewis A, McCrossan ZA, Abbott GW. MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J Biol Chem. 2004 Feb 27; 279(9):7884-92. PMID: 14679187.
      View in: PubMed
    84. Anantharam A, Markowitz SM, Abbott GW. Pharmacogenetic considerations in diseases of cardiac ion channels. J Pharmacol Exp Ther. 2003 Dec; 307(3):831-8. PMID: 14561846.
      View in: PubMed
    85. McCrossan ZA, Lewis A, Panaghie G, Jordan PN, Christini DJ, Lerner DJ, Abbott GW. MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci. 2003 Sep 03; 23(22):8077-91. PMID: 12954870.
      View in: PubMed
    86. Tai KK, McCrossan ZA, Abbott GW. Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. J Neurochem. 2003 Mar; 84(5):1193-200. PMID: 12603842.
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    87. Anantharam A, Lewis A, Panaghie G, Gordon E, McCrossan ZA, Lerner DJ, Abbott GW. RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. J Biol Chem. 2003 Apr 04; 278(14):11739-45. PMID: 12529362.
      View in: PubMed
    88. Abbott GW, Goldstein SA. Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB J. 2002 Mar; 16(3):390-400. PMID: 11874988.
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