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The focal adhesion protein Testin modulates KCNE2 potassium channel ß subunit activity. Channels (Austin). 2021 Dec; 15(1):229-238.
Papanikolaou M, Crump SM, Abbott GW. PMID: 33464998.
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PubMed Mentions: Fields:
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Dynein regulates Kv7.4 channel trafficking from the cell membrane. J Gen Physiol. 2021 Mar 01; 153(3).
van der Horst J, Rognant S, Abbott GW, Ozhathil LC, Hägglund P, Barrese V, Chuang CY, Jespersen T, Davies MJ, Greenwood IA, Gourdon P, Aalkjær C, Jepps TA. PMID: 33533890.
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PubMed Mentions: Fields:
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Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis. Commun Biol. 2020 Jul 30; 3(1):409.
PMID: 32732995.
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The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator. Commun Biol. 2020 Jul 08; 3(1):356.
Redford KE, Abbott GW. PMID: 32641720.
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Author Correction: Allosteric regulation of mammalian Na+/I- symporter activity by perchlorate. Nat Struct Mol Biol. 2020 Jul; 27(7):683.
PMID: 32472109.
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PubMed Mentions: Fields:
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Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion. FASEB J. 2020 Aug; 34(8):10699-10719.
Lisewski U, Köhncke C, Schleussner L, Purfürst B, Lee SM, De Silva A, Manville RW, Abbott GW, Roepke TK. PMID: 32584506.
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PubMed Mentions: Fields:
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KCNQs: Ligand- and Voltage-Gated Potassium Channels. Front Physiol. 2020; 11:583.
Abbott GW. PMID: 32655402.
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PubMed Mentions:
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Allosteric regulation of mammalian Na+/I- symporter activity by perchlorate. Nat Struct Mol Biol. 2020 06; 27(6):533-539.
Llorente-Esteban A, Manville RW, Reyna-Neyra A, Abbott GW, Amzel LM, Carrasco N. PMID: 32451489.
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HumansAnimalsCells
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Isoform-Selective KCNA1 Potassium Channel Openers Built from Glycine. J Pharmacol Exp Ther. 2020 06; 373(3):391-401.
Manville RW, Abbott GW. PMID: 32217768.
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PubMed Mentions:
4 Fields:
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HumansAnimals
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Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly. Arterioscler Thromb Vasc Biol. 2020 05; 40(5):1207-1219.
van der Horst J, Manville RW, Hayes K, Thomsen MB, Abbott GW, Jepps TA. PMID: 32188278.
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AnimalsCells
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Potassium channels act as chemosensors for solute transporters. Commun Biol. 2020 02 28; 3(1):90.
Manville RW, Abbott GW. PMID: 32111967.
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M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body ß-Hydroxybutyrate. J Pharmacol Exp Ther. 2020 02; 372(2):148-156.
Manville RW, Papanikolaou M, Abbott GW. PMID: 31757819.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner. Commun Biol. 2019; 2:401.
Manville RW, Abbott GW. PMID: 31701029.
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KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21236-21245.
Manville RW, van der Horst J, Redford KE, Katz BB, Jepps TA, Abbott GW. PMID: 31570602.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Association of Myoinositol Transporters with Schizophrenia and Bipolar Disorder: Evidence from Human and Animal Studies. Mol Neuropsychiatry. 2019 Oct; 5(4):200-211.
Vawter MP, Hamzeh AR, Muradyan E, Civelli O, Abbott GW, Alachkar A. PMID: 31768373.
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PubMed Mentions:
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Cilantro leaf harbors a potent potassium channel-activating anticonvulsant. FASEB J. 2019 10; 33(10):11349-11363.
Manville RW, Abbott GW. PMID: 31311306.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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The KCNE2 potassium channel ß subunit is required for normal lung function and resilience to ischemia and reperfusion injury. FASEB J. 2019 09; 33(9):9762-9774.
Zhou L, Köhncke C, Hu Z, Roepke TK, Abbott GW. PMID: 31162977.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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Teamwork: Ion channels and transporters join forces in the brain. Neuropharmacology. 2019 12 15; 161:107601.
Manville RW, Abbott GW. PMID: 30959022.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice. . 2019 05 01; 316(5):R552-R562.
Hu Z, Jepps TA, Zhou L, Liu J, Li M, Abbott GW. PMID: 30758982.
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AKT and ERK1/2 activation via remote ischemic preconditioning prevents Kcne2-dependent sudden cardiac death. Physiol Rep. 2019 02; 7(3):e13957.
Hu Z, Liu J, Zhou L, Tian X, Abbott GW. PMID: 30737904.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity. J Cell Physiol. 2019 08; 234(8):13361-13369.
Harkcom WT, Papanikolaou M, Kanda V, Crump SM, Abbott GW. PMID: 30613966.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. Sci Adv. 2018 11; 4(11):eaav0824.
De Silva AM, Manville RW, Abbott GW. PMID: 30443601.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Deletion in mice of X-linked, Brugada syndrome- and atrial fibrillation-associated Kcne5 augments ventricular KV currents and predisposes to ventricular arrhythmia. FASEB J. 2019 02; 33(2):2537-2552.
David JP, Lisewski U, Crump SM, Jepps TA, Bocksteins E, Wilck N, Lossie J, Roepke TK, Schmitt N, Abbott GW. PMID: 30289750.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket. Nat Commun. 2018 09 21; 9(1):3845.
Manville RW, Abbott GW. PMID: 30242262.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels. Mol Pharmacol. 2018 10; 94(4):1155-1163.
Manville RW, Abbott GW. PMID: 30021858.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Kcne4 deletion sex-specifically predisposes to cardiac arrhythmia via testosterone-dependent impairment of RISK/SAFE pathway induction in aged mice. Sci Rep. 2018 05 29; 8(1):8258.
Hu Z, Wei W, Zhou L, Chen M, Abbott GW. PMID: 29844497.
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HumansAnimalsCells
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Remote ischemic preconditioning STAT3-dependently ameliorates pulmonary ischemia/reperfusion injury. PLoS One. 2018; 13(5):e0196186.
Luo N, Liu J, Chen Y, Li H, Hu Z, Abbott GW. PMID: 29768493.
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PubMed Mentions: Fields:
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AnimalsCells
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Direct neurotransmitter activation of voltage-gated potassium channels. Nat Commun. 2018 05 10; 9(1):1847.
Manville RW, Papanikolaou M, Abbott GW. PMID: 29748663.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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ß Subunits Control the Effects of Human Kv4.3 Potassium Channel Phosphorylation. Front Physiol. 2017; 8:646.
PMID: 28919864.
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Prenatal one-carbon metabolism dysregulation programs schizophrenia-like deficits. Mol Psychiatry. 2018 02; 23(2):282-294.
PMID: 28809400.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore. Biophys J. 2017 Aug 08; 113(3):613-626.
PMID: 28793216.
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PubMed Mentions:
10 Fields:
Translation:
HumansCells
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Chansporter complexes in cell signaling. FEBS Lett. 2017 09; 591(17):2556-2576.
Abbott GW. PMID: 28718502.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Remote ischemic preconditioning differentially attenuates post-ischemic cardiac arrhythmia in streptozotocin-induced diabetic versus nondiabetic rats. Cardiovasc Diabetol. 2017 04 26; 16(1):57.
PMID: 28446231.
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PubMed Mentions:
2 Fields:
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AnimalsCells
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Targeted deletion of Kcne3 impairs skeletal muscle function in mice. FASEB J. 2017 07; 31(7):2937-2947.
PMID: 28356343.
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AnimalsCells
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KCNQ-SMIT complex formation facilitates ion channel-solute transporter cross talk. FASEB J. 2017 07; 31(7):2828-2838.
PMID: 28283543.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Kcne2 deletion impairs insulin secretion and causes type 2 diabetes mellitus. FASEB J. 2017 06; 31(6):2674-2685.
PMID: 28280005.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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ß Subunits Functionally Differentiate Human Kv4.3 Potassium Channel Splice Variants. Front Physiol. 2017; 8:66.
PMID: 28228734.
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Involvement of glycogen synthase kinase-3ß in liver ischemic conditioning induced cardioprotection against myocardial ischemia and reperfusion injury in rats. J Appl Physiol (1985). 2017 May 01; 122(5):1095-1105.
PMID: 28153944.
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PubMed Mentions:
3 Fields:
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AnimalsCells
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Correction: Channel-transporter complexes: an emerging theme in cell signalling. Biochem J. 2016 12 15; 473(24):4714.
PMID: 27941032.
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PubMed Mentions: Fields:
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Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4. Sci Rep. 2016 12 06; 6:38412.
PMID: 27922120.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Channel-transporter complexes: an emerging theme in cell signaling. Biochem J. 2016 11 01; 473(21):3759-3763.
PMID: 27789743.
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PubMed Mentions: Fields:
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HumansAnimalsCells
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Remote Liver Ischemic Preconditioning Protects against Sudden Cardiac Death via an ERK/GSK-3ß-Dependent Mechanism. PLoS One. 2016; 11(10):e0165123.
PMID: 27768739.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity. J Vasc Res. 2016; 53(3-4):138-148.
PMID: 27710966.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis. Gene. 2016 Nov 30; 593(2):249-60.
PMID: 27484720.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4. FASEB J. 2016 08; 30(8):2959-69.
PMID: 27162025.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Ion channel-transporter interactions. Crit Rev Biochem Mol Biol. 2015 Jul-Aug; 51(4):257-67.
PMID: 27098917.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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KCNE2 and gastric cancer: bench to bedside. Oncotarget. 2016 Apr 05; 7(14):17286-7.
PMID: 26956055.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Kcne2 deletion causes early-onset nonalcoholic fatty liver disease via iron deficiency anemia. Sci Rep. 2016 Mar 17; 6:23118.
PMID: 26984260.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Kcne2 deletion attenuates acute post-ischaemia/reperfusion myocardial infarction. Cardiovasc Res. 2016 May 15; 110(2):227-37.
PMID: 26952045.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation. Gene. 2016 Jan 15; 576(1 Pt 1):1-13.
PMID: 26410412.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice. FASEB J. 2016 Jan; 30(1):360-9.
PMID: 26399785.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Pharmacogenetic diversification by alternative translation initiation: background channels to the fore: Commentary on Kisselbach et?al., Br J Pharmacol 171: 5182-5194. Br J Pharmacol. 2015 Sep; 172(18):4591-4593.
Abbott GW. PMID: 24528336.
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Kcne2 deletion promotes atherosclerosis and diet-dependent sudden death. J Mol Cell Cardiol. 2015 Oct; 87:148-51.
PMID: 26307149.
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7 Fields:
Translation:
HumansAnimals
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The KCNE2 K? channel regulatory subunit: Ubiquitous influence, complex pathobiology. Gene. 2015 Sep 15; 569(2):162-72.
PMID: 26123744.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Ion channels under the sun. FASEB J. 2014 May; 28(5):1957-62.
PMID: 24786286.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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KCNQ1, KCNE2, and Na+-coupled solute transporters form reciprocally regulating complexes that affect neuronal excitability. Sci Signal. 2014 Mar 04; 7(315):ra22.
PMID: 24595108.
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PubMed Mentions:
30 Fields:
Translation:
AnimalsCells
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Arrhythmogenic KCNE gene variants: current knowledge and future challenges. Front Genet. 2014; 5:3.
PMID: 24478792.
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Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014 Feb 28; 289(9):5889-903.
PMID: 24403084.
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PubMed Mentions:
10 Fields:
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HumansAnimalsCells
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Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death. Circ Cardiovasc Genet. 2014 Feb; 7(1):33-42.
PMID: 24403551.
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PubMed Mentions:
19 Fields:
Translation:
Animals
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NHE isoform switching and KChIP2 upregulation in aging porcine atria. PLoS One. 2013; 8(12):e82951.
PMID: 24376615.
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AnimalsCells
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Kcne3 deletion initiates extracardiac arrhythmogenesis in mice. FASEB J. 2014 Feb; 28(2):935-45.
PMID: 24225147.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Emulsified isoflurane postconditioning produces cardioprotection against myocardial ischemia-reperfusion injury in rats. J Physiol Sci. 2013 Jul; 63(4):251-61.
PMID: 23625523.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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KCNE genetics and pharmacogenomics in cardiac arrhythmias: much ado about nothing? Expert Rev Clin Pharmacol. 2013 Jan; 6(1):49-60.
PMID: 23272793.
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PubMed Mentions:
8 Fields:
Translation:
Humans
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Interaction between soluble and membrane-embedded potassium channel peptides monitored by Fourier transform infrared spectroscopy. PLoS One. 2012; 7(11):e49070.
PMID: 23145073.
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PubMed Mentions:
1 Fields:
Translation:
Cells
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Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits. PLoS One. 2012; 7(8):e42756.
PMID: 22880098.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task? Front Physiol. 2012; 3:231.
PMID: 22754540.
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Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy. J Mol Cell Cardiol. 2012 Sep; 53(3):350-3.
PMID: 22641150.
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PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
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The KCNQ1-KCNE2 K? channel is required for adequate thyroid I? uptake. FASEB J. 2012 Aug; 26(8):3252-9.
PMID: 22549510.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study. PLoS Comput Biol. 2012; 8(2):e1002390.
PMID: 22383869.
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PubMed Mentions:
34 Fields:
Translation:
HumansCells
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KCNE2 and the K (+) channel: the tail wagging the dog. Channels (Austin). 2012 Jan-Feb; 6(1):1-10.
PMID: 22513486.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels. Biophys J. 2011 Sep 21; 101(6):1354-63.
PMID: 21943416.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition. Biophys J. 2011 Sep 21; 101(6):1364-75.
PMID: 21943417.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
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KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium. FASEB J. 2011 Dec; 25(12):4264-73.
Roepke TK, Kanda VA, Purtell K, King EC, Lerner DJ, Abbott GW. PMID: 21859894.
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PubMed Mentions:
20 Fields:
Translation:
Animals
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Protein kinase C downregulates I(Ks) by stimulating KCNQ1-KCNE1 potassium channel endocytosis. Heart Rhythm. 2011 Oct; 8(10):1641-7.
Kanda VA, Purtell K, Abbott GW. PMID: 21699843.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Genetic dissection reveals unexpected influence of beta subunits on KCNQ1 K+ channel polarized trafficking in vivo. FASEB J. 2011 Feb; 25(2):727-36.
Roepke TK, King EC, Purtell K, Kanda VA, Lerner DJ, Abbott GW. PMID: 21084694.
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PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
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Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. Int J Biochem Cell Biol. 2010 Nov; 42(11):1767-70.
Purtell K, Roepke TK, Abbott GW. PMID: 20688187.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking. Expert Rev Cardiovasc Ther. 2010 Aug; 8(8):1161-73.
Harkcom WT, Abbott GW. PMID: 20670193.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
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Targeted deletion of Kcne2 causes gastritis cystica profunda and gastric neoplasia. PLoS One. 2010 Jul 06; 5(7):e11451.
Roepke TK, Purtell K, King EC, La Perle KM, Lerner DJ, Abbott GW. PMID: 20625512.
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PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCells
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A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor. FASEB J. 2010 May; 24(5):1518-24.
Choi E, Abbott GW. PMID: 20040519.
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PubMed Mentions:
11 Fields:
Translation:
HumansCells
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Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis. Nat Med. 2009 Oct; 15(10):1186-94.
Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW. PMID: 19767733.
View in:
PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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Dynamical mechanism for subcellular alternans in cardiac myocytes. Circ Res. 2009 Aug 14; 105(4):335-42.
Gaeta SA, Bub G, Abbott GW, Christini DJ. PMID: 19628792.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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HERG biosynthesis: the positive influence of negative charge. . 2009 May; 296(5):H1211-2.
Abbott GW, Roepke TK. PMID: 19286960.
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Regulation of the Kv2.1 potassium channel by MinK and MiRP1. J Membr Biol. 2009 Mar; 228(1):1-14.
McCrossan ZA, Roepke TK, Lewis A, Panaghie G, Abbott GW. PMID: 19219384.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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MinK-dependent internalization of the IKs potassium channel. Cardiovasc Res. 2009 Jun 01; 82(3):430-8.
Xu X, Kanda VA, Choi E, Panaghie G, Roepke TK, Gaeta SA, Christini DJ, Lerner DJ, Abbott GW. PMID: 19202166.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f). FASEB J. 2008 Oct; 22(10):3648-60.
Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW. PMID: 18603586.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
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Voltage-dependent C-type inactivation in a constitutively open K+ channel. Biophys J. 2008 Sep 15; 95(6):2759-78.
Panaghie G, Purtell K, Tai KK, Abbott GW. PMID: 18567635.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels. J Pharmacol Exp Ther. 2008 Sep; 326(3):871-8.
Morrey C, Estephan R, Abbott GW, Levi R. PMID: 18523159.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature. 2008 May 22; 453(7194):524-8.
Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM. PMID: 18432194.
View in:
PubMed Mentions:
548 Fields:
Translation:
HumansCells
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Pharmacogenetics of drug-induced arrhythmias. Expert Rev Clin Pharmacol. 2008 Jan; 1(1):93-104.
PMID: 24410513.
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PubMed Mentions:
3 Fields:
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Secondary structure of the MiRP1 (KCNE2) potassium channel ancillary subunit. Protein Pept Lett. 2008; 15(1):63-75.
Abbott GW, Ramesh B, Srai SK. PMID: 18221016.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Impact of ancillary subunits on ventricular repolarization. J Electrocardiol. 2007 Nov-Dec; 40(6 Suppl):S42-6.
Abbott GW, Xu X, Roepke TK. PMID: 17993327.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance. Cardiovasc Res. 2008 Jan; 77(1):98-106.
Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, Abbott GW. PMID: 18006462.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease. Mol Pharmacol. 2007 Sep; 72(3):499-501.
Choi E, Abbott GW. PMID: 17595326.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. J Gen Physiol. 2007 Feb; 129(2):121-33.
Panaghie G, Abbott GW. PMID: 17227916.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimalsCells
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The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem. 2006 Aug 18; 281(33):23740-7.
Roepke TK, Anantharam A, Kirchhoff P, Busque SM, Young JB, Geibel JP, Lerner DJ, Abbott GW. PMID: 16754665.
View in:
PubMed Mentions:
71 Fields:
Translation:
AnimalsCells
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Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. FASEB J. 2006 Feb; 20(2):293-301.
Abbott GW, Butler MH, Goldstein SA. PMID: 16449802.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels. Curr Pharm Des. 2006; 12(18):2285-302.
Panaghie G, Abbott GW. PMID: 16787255.
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13 Fields:
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HumansAnimalsCells
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Molecular mechanisms of cardiac voltage-gated potassium channelopathies. Curr Pharm Des. 2006; 12(28):3631-44.
Abbott GW. PMID: 17073664.
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9 Fields:
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Humans
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Pharmacogenetics and cardiac ion channels. Vascul Pharmacol. 2006 Feb; 44(2):90-106.
Roepke TK, Abbott GW. PMID: 16344000.
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6 Fields:
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HumansCells
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Endogenous KCNE subunits govern Kv2.1 K+ channel activation kinetics in Xenopus oocyte studies. Biophys J. 2006 Feb 15; 90(4):1223-31.
Gordon E, Roepke TK, Abbott GW. PMID: 16326911.
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12 Fields:
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AnimalsCells
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1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar; 69(3):718-26.
Gordon E, Cohen JL, Engel R, Abbott GW. PMID: 16317109.
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2 Fields:
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AnimalsCells
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Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol. 2006 Feb 01; 570(Pt 3):455-67.
Panaghie G, Tai KK, Abbott GW. PMID: 16308347.
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62 Fields:
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HumansAnimalsCells
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Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther. 2005 Nov; 315(2):517-25.
Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. PMID: 16033909.
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26 Fields:
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HumansAnimalsCells
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Does hERG coassemble with a beta subunit? Evidence for roles of MinK and MiRP1. Novartis Found Symp. 2005; 266:100-12; discussion 112-7, 155-8.
Anantharam A, Abbott GW. PMID: 16050264.
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9 Fields:
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HumansAnimalsCells
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The MinK-related peptides. Neuropharmacology. 2004 Nov; 47(6):787-821.
McCrossan ZA, Abbott GW. PMID: 15527815.
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129 Fields:
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HumansAnimalsCells
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MinK, MiRP1, and MiRP2 diversify Kv3.1 and Kv3.2 potassium channel gating. J Biol Chem. 2004 Feb 27; 279(9):7884-92.
Lewis A, McCrossan ZA, Abbott GW. PMID: 14679187.
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31 Fields:
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HumansAnimalsCells
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Pharmacogenetic considerations in diseases of cardiac ion channels. J Pharmacol Exp Ther. 2003 Dec; 307(3):831-8.
Anantharam A, Markowitz SM, Abbott GW. PMID: 14561846.
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9 Fields:
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HumansAnimals
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MinK-related peptide 2 modulates Kv2.1 and Kv3.1 potassium channels in mammalian brain. J Neurosci. 2003 Sep 03; 23(22):8077-91.
McCrossan ZA, Lewis A, Panaghie G, Jordan PN, Christini DJ, Lerner DJ, Abbott GW. PMID: 12954870.
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33 Fields:
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HumansAnimalsCells
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Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death. J Neurochem. 2003 Mar; 84(5):1193-200.
Tai KK, McCrossan ZA, Abbott GW. PMID: 12603842.
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PubMed Mentions:
13 Fields:
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AnimalsCells
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RNA interference reveals that endogenous Xenopus MinK-related peptides govern mammalian K+ channel function in oocyte expression studies. J Biol Chem. 2003 Apr 04; 278(14):11739-45.
Anantharam A, Lewis A, Panaghie G, Gordon E, McCrossan ZA, Lerner DJ, Abbott GW. PMID: 12529362.
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21 Fields:
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HumansAnimalsCells
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Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. FASEB J. 2002 Mar; 16(3):390-400.
Abbott GW, Goldstein SA. PMID: 11874988.
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33 Fields:
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AnimalsCells
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Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs). Mol Interv. 2001 Jun; 1(2):95-107.
Abbott GW, Goldstein SA. PMID: 14993329.
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27 Fields:
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HumansAnimalsCells
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Do all voltage-gated potassium channels use MiRPs? Circ Res. 2001 May 25; 88(10):981-3.
Abbott GW, Goldstein SA, Sesti F. PMID: 11375265.
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13 Fields:
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AnimalsCells
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MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell. 2001 Jan 26; 104(2):217-31.
Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, Goldstein SA. PMID: 11207363.
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85 Fields:
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HumansAnimalsCells
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A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10613-8.
Sesti F, Abbott GW, Wei J, Murray KT, Saksena S, Schwartz PJ, Priori SG, Roden DM, George AL, Goldstein SA. PMID: 10984545.
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106 Fields:
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MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16; 97(2):175-87.
Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. PMID: 10219239.
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297 Fields:
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A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q Rev Biophys. 1998 Nov; 31(4):357-98.
Abbott GW, Goldstein SA. PMID: 10709243.
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41 Fields:
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HumansAnimals
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Conformational changes in a mammalian voltage-dependent potassium channel inactivation peptide. Biochemistry. 1998 Feb 10; 37(6):1640-5.
Abbott GW, Mercer EA, Miller RT, Ramesh B, Srai SK. PMID: 9484235.
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5 Fields:
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HumansCells
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Secondary structure, stability and tetramerisation of recombinant K(V)1.1 potassium channel cytoplasmic N-terminal fragment. Biochim Biophys Acta. 1997 Aug 15; 1341(1):71-8.
Abbott GW, Bloemendal M, Van Stokkum IH, Mercer EA, Miller RT, Sewing S, Wolters M, Pongs O, Srai SK. PMID: 9300810.
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Cells
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Synthetic putative transmembrane region of minimal potassium channel protein (minK) adopts an alpha-helical conformation in phospholipid membranes. Biochem J. 1997 Jul 15; 325 ( Pt 2):475-9.
Mercer EA, Abbott GW, Brazier SP, Ramesh B, Haris PI, Srai SK. PMID: 9230130.
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8 Fields:
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Cells
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Structural characterisation of a slowly activating potassium channel (IsK). Biochem Soc Trans. 1995 Aug; 23(3):478S.
Mercer EA, Abbott GW, Ramesh B, Haris PI, Chapman D, Srai SK. PMID: 8566375.
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2 Fields:
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HumansAnimalsCells
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Structure analysis of a recombinant voltage-gated potassium channel (Kv1.1) N-terminus using FTIR spectroscopy and thermal denaturation. Biochem Soc Trans. 1995 Aug; 23(3):479S.
Abbott GW, Mercer EA, Wolters M, Sewing S, Pongs O, Srai SK. PMID: 8566376.
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AnimalsCells