Enrico Gratton

InstitutionUniversity of California, Irvine
DepartmentBiomedical Engineering
Address3210 Natural Sciences II
Zot 2715
Irvine CA 92697
Phone(949) 824-2674
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    Collapse Research 
    Collapse Research Activities and Funding
    Imaging of Brain Function Using Near-Infrared Methods
    NIH/NIBIB R01EB000559Sep 1, 2002 - Jul 31, 2006
    Role: Principal Investigator
    Laboratory for Fluorescence Dynamics
    NIH/NIGMS P41GM103540Aug 1, 1997 - Jun 30, 2021
    Role: Principal Investigator
    Vascular Insufficiency in Brain Circulation
    NIH/NICHD R01HD041342Sep 1, 1995 - Aug 31, 2005
    Role: Principal Investigator
    NIH/NCRR R01RR010966Sep 1, 1995 - Aug 31, 2001
    Role: Principal Investigator
    NIH/FIC R03TW000427Mar 1, 1994 - Feb 28, 1998
    Role: Principal Investigator
    NIH/NCI R01CA057032Apr 1, 1992 - Nov 30, 2001
    Role: Principal Investigator
    Laboratory for Fluorescence Dynamics
    NIH/NCRR P41RR003155Aug 1, 1986 - Jun 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen H, Ma N, Kagawa K, Kawahito S, Digman M, Gratton E. Widefield multi-frequency fluorescence lifetime imaging using a two-tap CMOS camera with lateral electric field charge modulators. J Biophotonics. 2018 Nov 12; e201800223. PMID: 30421535.
      View in: PubMed
    2. Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Adariani SR, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, Gebhardt C, Götz M, Gouridis G, Gratton E, Ha T, Hao P, Hanke CA, Hartmann A, Hendrix J, Hildebrandt LL, Hirschfeld V, Hohlbein J, Hua B, Hübner CG, Kallis E, Kapanidis AN, Kim JY, Krainer G, Lamb DC, Lee NK, Lemke EA, Levesque B, Levitus M, McCann JJ, Naredi-Rainer N, Nettels D, Ngo T, Qiu R, Robb NC, Röcker C, Sanabria H, Schlierf M, Schröder T, Schuler B, Seidel H, Streit L, Thurn J, Tinnefeld P, Tyagi S, Vandenberk N, Vera AM, Weninger KR, Wünsch B, Yanez-Orozco IS, Michaelis J, Seidel CAM, Craggs TD, Hugel T. Publisher Correction: Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nat Methods. 2018 Nov; 15(11):984. PMID: 30327572.
      View in: PubMed
    3. Ranjit S, Malacrida L, Gratton E. Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microsc Res Tech. 2018 Oct 08. PMID: 30295346.
      View in: PubMed
    4. Ranjit S, Malacrida L, Jameson DM, Gratton E. Fit-free analysis of fluorescence lifetime imaging data using the phasor approach. Nat Protoc. 2018 Sep; 13(9):1979-2004. PMID: 30190551.
      View in: PubMed
    5. Hellenkamp B, Schmid S, Doroshenko O, Opanasyuk O, Kühnemuth R, Rezaei Adariani S, Ambrose B, Aznauryan M, Barth A, Birkedal V, Bowen ME, Chen H, Cordes T, Eilert T, Fijen C, Gebhardt C, Götz M, Gouridis G, Gratton E, Ha T, Hao P, Hanke CA, Hartmann A, Hendrix J, Hildebrandt LL, Hirschfeld V, Hohlbein J, Hua B, Hübner CG, Kallis E, Kapanidis AN, Kim JY, Krainer G, Lamb DC, Lee NK, Lemke EA, Levesque B, Levitus M, McCann JJ, Naredi-Rainer N, Nettels D, Ngo T, Qiu R, Robb NC, Röcker C, Sanabria H, Schlierf M, Schröder T, Schuler B, Seidel H, Streit L, Thurn J, Tinnefeld P, Tyagi S, Vandenberk N, Vera AM, Weninger KR, Wünsch B, Yanez-Orozco IS, Michaelis J, Seidel CAM, Craggs TD, Hugel T. Precision and accuracy of single-molecule FRET measurements-a multi-laboratory benchmark study. Nat Methods. 2018 Sep; 15(9):669-676. PMID: 30171252.
      View in: PubMed
    6. Dvornikov A, Gratton E. Hyperspectral imaging in highly scattering media by the spectral phasor approach using two filters. Biomed Opt Express. 2018 Aug 01; 9(8):3503-3511. PMID: 30338135.
      View in: PubMed
    7. Malacrida L, Gratton E. LAURDAN fluorescence and phasor plots reveal the effects of a H2O2 bolus in NIH-3T3 fibroblast membranes dynamics and hydration. Free Radic Biol Med. 2018 Nov 20; 128:144-156. PMID: 29885356.
      View in: PubMed
    8. Pedrote MM, de Oliveira GAP, Felix AL, Mota MF, Marques MA, Soares IN, Iqbal A, Norberto DR, Gomes AMO, Gratton E, Cino EA, Silva JL. Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer. J Biol Chem. 2018 Jul 20; 293(29):11374-11387. PMID: 29853637.
      View in: PubMed
    9. Malacrida L, Rao E, Gratton E. Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: The case of the epidermal growth factor receptor. Methods. 2018 May 01; 140-141:74-84. PMID: 29501424.
      View in: PubMed
    10. Staaf E, Hedde PN, Bagawath Singh S, Piguet J, Gratton E, Johansson S. Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A. Sci Signal. 2018 Feb 13; 11(517). PMID: 29440510.
      View in: PubMed
    11. Mäntylä E, Chacko JV, Aho V, Parrish CR, Shahin V, Kann M, Digman MA, Gratton E, Vihinen-Ranta M. Viral highway to nucleus exposed by image correlation analyses. Sci Rep. 2018 01 18; 8(1):1152. PMID: 29348472.
      View in: PubMed
    12. Gach JS, Bouzin M, Wong MP, Chromikova V, Gorlani A, Yu KT, Sharma B, Gratton E, Forthal DN. Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis. PLoS Pathog. 2017 Dec; 13(12):e1006793. PMID: 29281723.
      View in: PubMed
    13. Malacrida L, Hedde PN, Ranjit S, Cardarelli F, Gratton E. Visualization of barriers and obstacles to molecular diffusion in live cells by spatial pair-cross-correlation in two dimensions. Biomed Opt Express. 2018 01 01; 9(1):303-321. PMID: 29359105.
      View in: PubMed
    14. Davey RJ, Digman MA, Gratton E, Moens PDJ. Quantitative image mean squared displacement (iMSD) analysis of the dynamics of profilin 1 at the membrane of live cells. Methods. 2018 May 01; 140-141:119-125. PMID: 29242135.
      View in: PubMed
    15. Wang XX, Wang D, Luo Y, Myakala K, Dobrinskikh E, Rosenberg AZ, Levi J, Kopp JB, Field A, Hill A, Lucia S, Qiu L, Jiang T, Peng Y, Orlicky D, Garcia G, Herman-Edelstein M, D'Agati V, Henriksen K, Adorini L, Pruzanski M, Xie C, Krausz KW, Gonzalez FJ, Ranjit S, Dvornikov A, Gratton E, Levi M. FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity. J Am Soc Nephrol. 2018 Jan; 29(1):118-137. PMID: 29089371.
      View in: PubMed
    16. Bohórquez-Hernández A, Gratton E, Pacheco J, Asanov A, Vaca L. Cholesterol modulates the cellular localization of Orai1 channels and its disposition among membrane domains. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Dec; 1862(12):1481-1490. PMID: 28919480.
      View in: PubMed
    17. Malacrida L, Jameson DM, Gratton E. A multidimensional phasor approach reveals LAURDAN photophysics in NIH-3T3 cell membranes. Sci Rep. 2017 Aug 23; 7(1):9215. PMID: 28835608.
      View in: PubMed
    18. Hedde PN, Malacrida L, Ahrar S, Siryaporn A, Gratton E. sideSPIM - selective plane illumination based on a conventional inverted microscope. Biomed Opt Express. 2017 Sep 01; 8(9):3918-3937. PMID: 29026679.
      View in: PubMed
    19. Stortz M, Presman DM, Bruno L, Annibale P, Dansey MV, Burton G, Gratton E, Pecci A, Levi V. Mapping the Dynamics of the Glucocorticoid Receptor within the Nuclear Landscape. Sci Rep. 2017 Jul 24; 7(1):6219. PMID: 28740156.
      View in: PubMed
    20. Ranjit S, Dvornikov A, Dobrinskikh E, Wang X, Luo Y, Levi M, Gratton E. Erratum: Measuring the effect of Western diet on liver tissue architecture by FLIM autofluorescence and harmonic generation microscopy: erratum. Biomed Opt Express. 2017 Jul 01; 8(7):3501. PMID: 28717585.
      View in: PubMed
    21. Bhattacharjee A, Datta R, Gratton E, Hochbaum AI. Metabolic fingerprinting of bacteria by fluorescence lifetime imaging microscopy. Sci Rep. 2017 Jun 16; 7(1):3743. PMID: 28623341.
      View in: PubMed
    22. Ranjit S, Dvornikov A, Dobrinskikh E, Wang X, Luo Y, Levi M, Gratton E. Measuring the effect of a Western diet on liver tissue architecture by FLIM autofluorescence and harmonic generation microscopy. Biomed Opt Express. 2017 Jul 01; 8(7):3143-3154. PMID: 28717559.
      View in: PubMed
    23. Herrington KA, Trinh AL, Dang C, O'Shaughnessy E, Hahn KM, Gratton E, Digman MA, Sütterlin C. Spatial analysis of Cdc42 activity reveals a role for plasma membrane-associated Cdc42 in centrosome regulation. Mol Biol Cell. 2017 Jul 15; 28(15):2135-2145. PMID: 28539409.
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    24. Ceccarelli A, Di Venere A, Nicolai E, De Luca A, Rosato N, Gratton E, Mei G, Caccuri AM. New insight into the interaction of TRAF2 C-terminal domain with lipid raft microdomains. Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep; 1862(9):813-822. PMID: 28499815.
      View in: PubMed
    25. Aguilar-Arnal L, Ranjit S, Stringari C, Orozco-Solis R, Gratton E, Sassone-Corsi P. Spatial dynamics of SIRT1 and the subnuclear distribution of NADH species. Proc Natl Acad Sci U S A. 2016 Oct 24. PMID: 27791113.
      View in: PubMed
    26. Cinco R, Digman MA, Gratton E, Luderer U. Spatial Characterization of Bioenergetics and Metabolism of Primordial to Preovulatory Follicles in Whole Ex Vivo Murine Ovary. Biol Reprod. 2016 12; 95(6):129. PMID: 27683265.
      View in: PubMed
    27. Chen H, Gratton E, Digman MA. Self-assisted optothermal trapping of gold nanorods under two-photon excitation. Methods Appl Fluoresc. 2016 09 06; 4(3):035003. PMID: 28355163.
      View in: PubMed
    28. Dvornikov A, Gratton E. Imaging in turbid media: a transmission detector gives 2-3 order of magnitude enhanced sensitivity compared to epi-detection schemes. Biomed Opt Express. 2016 Sep 01; 7(9):3747-3755. PMID: 27699135.
      View in: PubMed
    29. Di Rienzo C, Gratton E, Beltram F, Cardarelli F. Spatiotemporal Fluctuation Analysis: A Powerful Tool for the Future Nanoscopy of Molecular Processes. Biophys J. 2016 Aug 23; 111(4):679-685. PMID: 27558712; PMCID: PMC5002078 [Available on 08/23/17].
    30. Sobrino A, Phan DT, Datta R, Wang X, Hachey SJ, Romero-López M, Gratton E, Lee AP, George SC, Hughes CC. 3D microtumors in vitro supported by perfused vascular networks. Sci Rep. 2016 08 23; 6:31589. PMID: 27549930.
      View in: PubMed
    31. Di Rienzo C, Cardarelli F, Di Luca M, Beltram F, Gratton E. Diffusion Tensor Analysis by Two-Dimensional Pair Correlation of Fluorescence Fluctuations in Cells. Biophys J. 2016 Aug 23; 111(4):841-851. PMID: 27558727; PMCID: PMC5002073 [Available on 08/23/17].
    32. Ranjit S, Dobrinskikh E, Montford J, Dvornikov A, Lehman A, Orlicky DJ, Nemenoff R, Gratton E, Levi M, Furgeson S. Label-free fluorescence lifetime and second harmonic generation imaging microscopy improves quantification of experimental renal fibrosis. Kidney Int. 2016 11; 90(5):1123-1128. PMID: 27555119.
      View in: PubMed
    33. Ranjit S, Dvornikov A, Levi M, Furgeson S, Gratton E. Characterizing fibrosis in UUO mice model using multiparametric analysis of phasor distribution from FLIM images. Biomed Opt Express. 2016 Sep 01; 7(9):3519-3530. PMID: 27699117.
      View in: PubMed
    34. Scipioni L, Gratton E, Diaspro A, Lanzanò L. Phasor Analysis of Local ICS Detects Heterogeneity in Size and Number of Intracellular Vesicles. Biophys J. 2016 Aug 09; 111(3):619-629. PMID: 27508445; PMCID: PMC4982927 [Available on 08/09/17].
    35. Serebryannyy LA, Parilla M, Annibale P, Cruz CM, Laster K, Gratton E, Kudryashov D, Kosak ST, Gottardi CJ, de Lanerolle P. Persistent nuclear actin filaments inhibit transcription by RNA polymerase II. J Cell Sci. 2016 09 15; 129(18):3412-25. PMID: 27505898.
      View in: PubMed
    36. Malacrida L, Astrada S, Briva A, Bollati-Fogolín M, Gratton E, Bagatolli LA. Spectral phasor analysis of LAURDAN fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar body-like structures. Biochim Biophys Acta. 2016 11; 1858(11):2625-2635. PMID: 27480804.
      View in: PubMed
    37. Digiacomo L, Digman MA, Gratton E, Caracciolo G. Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles. Acta Biomater. 2016 09 15; 42:189-198. PMID: 27449340.
      View in: PubMed
    38. Noutsi P, Gratton E, Chaieb S. Assessment of Membrane Fluidity Fluctuations during Cellular Development Reveals Time and Cell Type Specificity. PLoS One. 2016; 11(6):e0158313. PMID: 27362860; PMCID: PMC4928918.
    39. Hedde PN, Gratton E. Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens. Microsc Res Tech. 2016 Jun 24. PMID: 27338568.
      View in: PubMed
    40. Lin S, Hedde PN, Venugopalan V, Gratton E, Khine M. Multi-scale silica structures for improved HIV-1 Capsid (p24) antigen detection. Analyst. 2016 Jun 20; 141(13):4181-8. PMID: 27163263.
      View in: PubMed
    41. Clark NM, Hinde E, Winter CM, Fisher AP, Crosti G, Blilou I, Gratton E, Benfey PN, Sozzani R. Tracking transcription factor mobility and interaction in Arabidopsis roots with fluorescence correlation spectroscopy. Elife. 2016 06 11; 5. PMID: 27288545; PMCID: PMC4946880.
    42. Ma N, Digman MA, Malacrida L, Gratton E. Measurements of absolute concentrations of NADH in cells using the phasor FLIM method. Biomed Opt Express. 2016 Jul 01; 7(7):2441-52. PMID: 27446681; PMCID: PMC4948605.
    43. Szymanska AF, Heylman C, Datta R, Gratton E, Nenadic Z. Automated detection and analysis of depolarization events in human cardiomyocytes using MaDEC. Comput Biol Med. 2016 08 01; 75:109-17. PMID: 27281718; PMCID: PMC4938768 [Available on 08/01/17].
    44. Cardarelli F, Digiacomo L, Marchini C, Amici A, Salomone F, Fiume G, Rossetta A, Gratton E, Pozzi D, Caracciolo G. The intracellular trafficking mechanism of Lipofectamine-based transfection reagents and its implication for gene delivery. Sci Rep. 2016 05 11; 6:25879. PMID: 27165510.
      View in: PubMed
    45. Borrego SL, Fahrmann J, Datta R, Stringari C, Grapov D, Zeller M, Chen Y, Wang P, Baldi P, Gratton E, Fiehn O, Kaiser P. Metabolic changes associated with methionine stress sensitivity in MDA-MB-468 breast cancer cells. Cancer Metab. 2016; 4:9. PMID: 27141305; PMCID: PMC4852440.
    46. Alfonso-García A, Smith TD, Datta R, Luu TU, Gratton E, Potma EO, Liu WF. Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy. J Biomed Opt. 2016 Apr 30; 21(4):46005. PMID: 27086689; PMCID: PMC4833856 [Available on 04/18/17].
    47. Sosnik J, Zheng L, Rackauckas CV, Digman M, Gratton E, Nie Q, Schilling TF. Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. Elife. 2016 Apr 12; 5:e14034. PMID: 27067377; PMCID: PMC4829421.
    48. Datta R, Heylman C, George SC, Gratton E. Label-free imaging of metabolism and oxidative stress in human induced pluripotent stem cell-derived cardiomyocytes. Biomed Opt Express. 2016 May 01; 7(5):1690-701. PMID: 27231614; PMCID: PMC4871074.
    49. Hinde E, Pandžic E, Yang Z, Ng IH, Jans DA, Bogoyevitch MA, Gratton E, Gaus K. Quantifying the dynamics of the oligomeric transcription factor STAT3 by pair correlation of molecular brightness. Nat Commun. 2016 Mar 24; 7:11047. PMID: 27009358; PMCID: PMC4820838.
    50. Brenner MD, Zhou R, Conway DE, Lanzano L, Gratton E, Schwartz MA, Ha T. Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension Sensing. Nano Lett. 2016 Mar 09; 16(3):2096-102. PMID: 26824190; PMCID: PMC4851340.
    51. Wang B, Rong X, Duerr MA, Hermanson DJ, Hedde PN, Wong JS, Vallim TQ, Cravatt BF, Gratton E, Ford DA, Tontonoz P. Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet. Cell Metab. 2016 Mar 08; 23(3):492-504. PMID: 26833026; PMCID: PMC4785086 [Available on 03/08/17].
    52. Annibale P, Dvornikov A, Gratton E. Optical measurement of focal offset in tunable lenses. Opt Express. 2016 Jan 25; 24(2):1031-6. PMID: 26832485; PMCID: PMC4741313 [Available on 01/12/17].
    53. Heylman C, Datta R, Sobrino A, George S, Gratton E. Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS One. 2015; 10(12):e0144572. PMID: 26695765; PMCID: PMC4690607.
    54. Lakhani VV, Hinde E, Gratton E, Elston TC. Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands. PLoS One. 2015; 10(11):e0143753. PMID: 26606145.
      View in: PubMed
    55. Malacrida L, Gratton E, Jameson DM. Model-free methods to study membrane environmental probes: a comparison of the spectral phasor and generalized polarization approaches. Methods Appl Fluoresc. 2015 Nov 12; 3(4):047001. PMID: 29148515.
      View in: PubMed
    56. Malacrida L, Gratton E, Jameson DM. Model-free methods to study membrane environmental probes: a comparison of the spectral phasor and generalized polarization approaches. Methods Appl Fluoresc. 2015 Dec; 3(4). PMID: 27182438.
      View in: PubMed
    57. Chen H, Holst G, Gratton E. Modulated CMOS camera for fluorescence lifetime microscopy. Microsc Res Tech. 2015 Dec; 78(12):1075-81. PMID: 26500051; PMCID: PMC4770881 [Available on 12/01/16].
    58. Zhang K, Kang DK, Ali MM, Liu L, Labanieh L, Lu M, Riazifar H, Nguyen TN, Zell JA, Digman MA, Gratton E, Li J, Zhao W. Digital quantification of miRNA directly in plasma using integrated comprehensive droplet digital detection. Lab Chip. 2015 Nov 07; 15(21):4217-26. PMID: 26387763; PMCID: PMC4631652 [Available on 11/07/16].
    59. Mieruszynski S, Digman MA, Gratton E, Jones MR. Characterization of exogenous DNA mobility in live cells through fluctuation correlation spectroscopy. Sci Rep. 2015 Sep 10; 5:13848. PMID: 26354725; PMCID: PMC4564760.
    60. Hedde PN, Ranjit S, Gratton E. 3D fluorescence anisotropy imaging using selective plane illumination microscopy. Opt Express. 2015 Aug 24; 23(17):22308-17. PMID: 26368202; PMCID: PMC4646523.
    61. Ranjit S, Dvornikov A, Stakic M, Hong SH, Levi M, Evans RM, Gratton E. Imaging Fibrosis and Separating Collagens using Second Harmonic Generation and Phasor Approach to Fluorescence Lifetime Imaging. Sci Rep. 2015 Aug 21; 5:13378. PMID: 26293987; PMCID: PMC4543938.
    62. Hendrix J, Baumgärtel V, Schrimpf W, Ivanchenko S, Digman MA, Gratton E, Kräusslich HG, Müller B, Lamb DC. Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers. J Cell Biol. 2015 Aug 17; 210(4):629-46. PMID: 26283800; PMCID: PMC4539982.
    63. Hinde E, Cardarelli F, Gratton E. Spatiotemporal regulation of Heterochromatin Protein 1-alpha oligomerization and dynamics in live cells. Sci Rep. 2015 Aug 04; 5:12001. PMID: 26238434; PMCID: PMC4523856.
    64. Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P. LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife. 2015 Jul 14; 4:e08009. PMID: 26173179; PMCID: PMC4517437.
    65. Adu-Gyamfi E, Johnson KA, Fraser ME, Scott JL, Soni SP, Jones KR, Digman MA, Gratton E, Tessier CR, Stahelin RV. Host Cell Plasma Membrane Phosphatidylserine Regulates the Assembly and Budding of Ebola Virus. J Virol. 2015 Sep; 89(18):9440-53. PMID: 26136573; PMCID: PMC4542376.
    66. Hedde PN, Gratton E. Active focus stabilization for upright selective plane illumination microscopy. Opt Express. 2015 Jun 01; 23(11):14707-14. PMID: 26072829; PMCID: PMC4523369.
    67. Mieruszynski S, Briggs C, Digman MA, Gratton E, Jones MR. Live Cell Characterization of DNA Aggregation Delivered through Lipofection. Sci Rep. 2015 May 27; 5:10528. PMID: 26013547; PMCID: PMC4444954.
    68. Annibale P, Dvornikov A, Gratton E. Electrically tunable lens speeds up 3D orbital tracking. Biomed Opt Express. 2015 Jun 01; 6(6):2181-90. PMID: 26114037; PMCID: PMC4473752.
    69. Datta R, Alfonso-García A, Cinco R, Gratton E. Fluorescence lifetime imaging of endogenous biomarker of oxidative stress. Sci Rep. 2015 May 20; 5:9848. PMID: 25993434; PMCID: PMC4438616.
    70. Anzalone A, Gabriel M, Estrada LC, Gratton E. Spectral properties of single gold nanoparticles in close proximity to biological fluorophores excited by 2-photon excitation. PLoS One. 2015; 10(4):e0124975. PMID: 25909648; PMCID: PMC4409109.
    71. Sanchez SA, Gratton E, Zanocco AL, Lemp E, Gunther G. Correction: Sucrose monoester micelles size determined by fluorescence correlation spectroscopy (FCS). PLoS One. 2015; 10(4):e0125123. PMID: 25885966; PMCID: PMC4401706.
    72. Olivera-Couto A, Salzman V, Mailhos M, Digman MA, Gratton E, Aguilar PS. Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium. Biophys J. 2015 Apr 07; 108(7):1633-1644. PMID: 25863055.
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    73. Lanzanò L, Coto Hernández I, Castello M, Gratton E, Diaspro A, Vicidomini G. Encoding and decoding spatio-temporal information for super-resolution microscopy. Nat Commun. 2015 Apr 02; 6:6701. PMID: 25833391; PMCID: PMC4384168.
    74. Rong X, Wang B, Dunham MM, Hedde PN, Wong JS, Gratton E, Young SG, Ford DA, Tontonoz P. Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015 Mar 25; 4. PMID: 25806685; PMCID: PMC4400582.
    75. Moens PDJ, Digman MA, Gratton E. Modes of diffusion of cholera toxin bound to GM1 on live cell membrane by image mean square displacement analysis. Biophys J. 2015 Mar 24; 108(6):1448-1458. PMID: 25809257.
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    76. Perumal V, Krishnan K, Gratton E, Dharmarajan AM, Fox SA. Number and brightness analysis of sFRP4 domains in live cells demonstrates vesicle association signal of the NLD domain and dynamic intracellular responses to Wnt3a. Int J Biochem Cell Biol. 2015 Jul; 64:91-6. PMID: 25805505; PMCID: PMC4464842.
    77. Annibale P, Gratton E. Single cell visualization of transcription kinetics variance of highly mobile identical genes using 3D nanoimaging. Sci Rep. 2015 Mar 19; 5:9258. PMID: 25788248; PMCID: PMC4365385.
    78. Plotegher N, Stringari C, Jahid S, Veronesi M, Girotto S, Gratton E, Bubacco L. NADH fluorescence lifetime is an endogenous reporter of a-synuclein aggregation in live cells. FASEB J. 2015 Jun; 29(6):2484-94. PMID: 25713058; PMCID: PMC4447231.
    79. Chen H, Gratton E, Digman MA. Spectral properties and dynamics of gold nanorods revealed by EMCCD-based spectral phasor method. Microsc Res Tech. 2015 Apr; 78(4):283-93. PMID: 25684346; PMCID: PMC4404027.
    80. Golfetto O, Hinde E, Gratton E. The Laurdan spectral phasor method to explore membrane micro-heterogeneity and lipid domains in live cells. Methods Mol Biol. 2015; 1232:273-90. PMID: 25331141.
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    81. Stringari C, Wang H, Geyfman M, Crosignani V, Kumar V, Takahashi JS, Andersen B, Gratton E. In vivo single-cell detection of metabolic oscillations in stem cells. Cell Rep. 2015 Jan 06; 10(1):1-7. PMID: 25543138; PMCID: PMC4340841.
    82. Di Rienzo C, Piazza V, Gratton E, Beltram F, Cardarelli F. Probing short-range protein Brownian motion in the cytoplasm of living cells. Nat Commun. 2014 Dec 23; 5:5891. PMID: 25532887; PMCID: PMC4281647.
    83. Ranjit S, Lanzano L, Gratton E. Mapping diffusion in a living cell via the phasor approach. Biophys J. 2014 Dec 16; 107(12):2775-2785. PMID: 25517145.
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    84. Ranjit S, Dvornikov A, Holland DA, Reinhart GD, Jameson DM, Gratton E. Application of three-photon excitation FCS to the study of protein oligomerization. J Phys Chem B. 2014 Dec 18; 118(50):14627-31. PMID: 25438088; PMCID: PMC4275161.
    85. Hedde PN, Stakic M, Gratton E. Rapid measurement of molecular transport and interaction inside living cells using single plane illumination. Sci Rep. 2014 Nov 14; 4:7048. PMID: 25394360; PMCID: PMC4231332.
    86. Kang DK, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun. 2014 Nov 13; 5:5427. PMID: 25391809; PMCID: PMC4243214.
    87. Bonaventura G, Barcellona ML, Golfetto O, Nourse JL, Flanagan LA, Gratton E. Laurdan monitors different lipids content in eukaryotic membrane during embryonic neural development. Cell Biochem Biophys. 2014 Nov; 70(2):785-94. PMID: 24839062; PMCID: PMC4228983.
    88. Adu-Gyamfi E, Soni SP, Jee CS, Digman MA, Gratton E, Stahelin RV. A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress. Viruses. 2014 Oct 17; 6(10):3837-54. PMID: 25330123; PMCID: PMC4213565.
    89. Di Rienzo C, Gratton E, Beltram F, Cardarelli F. From fast fluorescence imaging to molecular diffusion law on live cell membranes in a commercial microscope. J Vis Exp. 2014 Oct 09; (92):e51994. PMID: 25350683; PMCID: PMC4461222.
    90. Anzalone A, Annibale P, Gratton E. 3D orbital tracking in a modified two-photon microscope: an application to the tracking of intracellular vesicles. J Vis Exp. 2014 Oct 01; (92):e51794. PMID: 25350070; PMCID: PMC4274936.
    91. Nicolai E, Garau S, Favalli C, D'Agostini C, Gratton E, Motolese G, Rosato N. Evaluation of BiesseBioscreen as a new methodology for bacteriuria screening. New Microbiol. 2014 Oct; 37(4):495-501. PMID: 25387286; PMCID: PMC4273739.
    92. Bachir AI, Zareno J, Moissoglu K, Plow EF, Gratton E, Horwitz AR. Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions. Curr Biol. 2014 Aug 18; 24(16):1845-53. PMID: 25088556; PMCID: PMC4138543.
    93. Subashchandrabose SR, Krishnan K, Gratton E, Megharaj M, Naidu R. Potential of fluorescence imaging techniques to monitor mutagenic PAH uptake by microalga. Environ Sci Technol. 2014 Aug 19; 48(16):9152-60. PMID: 25020149; PMCID: PMC4140530.
    94. Hinde E, Kong X, Yokomori K, Gratton E. Chromatin dynamics during DNA repair revealed by pair correlation analysis of molecular flow in the nucleus. Biophys J. 2014 Jul 01; 107(1):55-65. PMID: 24988341; PMCID: PMC4119266.
    95. Chiu CL, Aguilar JS, Tsai CY, Wu G, Gratton E, Digman MA. Nanoimaging of focal adhesion dynamics in 3D. PLoS One. 2014; 9(6):e99896. PMID: 24959851; PMCID: PMC4069057.
    96. Lanzanò L, Gratton E. Orbital Single Particle Tracking on a commercial confocal microscope using piezoelectric stage feedback. Methods Appl Fluoresc. 2014 Jun 01; 2(2). PMID: 25419461.
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    97. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. PMID: 24825347; PMCID: PMC4194089.
    98. Paladino S, Lebreton S, Tivodar S, Formiggini F, Ossato G, Gratton E, Tramier M, Coppey-Moisan M, Zurzolo C. Golgi sorting regulates organization and activity of GPI proteins at apical membranes. Nat Chem Biol. 2014 May; 10(5):350-357. PMID: 24681536; PMCID: PMC4027978.
    99. Annibale P, Gratton E. Advanced fluorescence microscopy methods for the real-time study of transcription and chromatin dynamics. Transcription. 2014 Mar 12; 5. PMID: 24802848.
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    100. Crosignani V, Jahid S, Dvornikov AS, Gratton E. A deep tissue fluorescence imaging system with enhanced SHG detection capabilities. Microsc Res Tech. 2014 May; 77(5):368-73. PMID: 24610799; PMCID: PMC4009694.
    101. Hinde E, Yokomori K, Gaus K, Hahn KM, Gratton E. Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Sci Rep. 2014 Feb 27; 4:4219. PMID: 24573109; PMCID: PMC3936235.
    102. Annibale P, Gratton E. Advanced fluorescence microscopy methods for the real-time study of transcription and chromatin dynamics. Transcription. 2014; 5(2):e28425. PMID: 25764219; PMCID: PMC4214231.
    103. Sharma H, Digman MA, Felsinger N, Gratton E, Khine M. Enhanced emission of fluorophores on shrink-induced wrinkled composite structures. Opt Mater Express. 2014; 4(4):753-763. PMID: 25383253.
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    104. Chiu CL, Digman MA, Gratton E. Measuring actin flow in 3D cell protrusions. Biophys J. 2013 Oct 15; 105(8):1746-55. PMID: 24138850; PMCID: PMC3797595.
    105. Gehricke JG, Polzonetti C, Caburian C, Gratton E. Prefrontal hemodynamic changes during cigarette smoking in young adult smokers with and without ADHD. Pharmacol Biochem Behav. 2013 Nov; 112:78-81. PMID: 24125785; PMCID: PMC3854671.
    106. James NG, Digman MA, Ross JA, Barylko B, Wang L, Li J, Chen Y, Mueller JD, Gratton E, Albanesi JP, Jameson DM. A mutation associated with centronuclear myopathy enhances the size and stability of dynamin 2 complexes in cells. Biochim Biophys Acta. 2014 Jan; 1840(1):315-21. PMID: 24016602; PMCID: PMC3859711.
    107. Chiu CL, Gratton E. Axial super resolution topography of focal adhesion by confocal microscopy. Microsc Res Tech. 2013 Oct; 76(10):1070-8. PMID: 23897846; PMCID: PMC3871876.
    108. Chiu CL, Digman MA, Gratton E. Cell matrix remodeling ability shown by image spatial correlation. J Biophys. 2013; 2013:532030. PMID: 23935614; PMCID: PMC3725897.
    109. Di Rienzo C, Gratton E, Beltram F, Cardarelli F. Fast spatiotemporal correlation spectroscopy to determine protein lateral diffusion laws in live cell membranes. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12307-12. PMID: 23836651; PMCID: PMC3725058.
    110. Skinner JP, Swift KM, Ruan Q, Perfetto S, Gratton E, Tetin SY. Simplified confocal microscope for counting particles at low concentrations. Rev Sci Instrum. 2013 Jul; 84(7):074301. PMID: 23902088; PMCID: PMC3724729.
    111. Cutrale F, Salih A, Gratton E. Spectral phasor approach for fingerprinting of photo-activatable fluorescent proteins Dronpa, Kaede and KikGR. Methods Appl Fluoresc. 2013 Jun 04; 1(3):035001. PMID: 29148446.
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    112. Altamore I, Lanzano L, Gratton E. Dual channel detection of ultra low concentration of bacteria in real time by scanning FCS. Meas Sci Technol. 2013 Jun 01; 24(6):65702. PMID: 24039347.
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    113. Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1. Curr Biol. 2013 Jun 03; 23(11):1024-30. PMID: 23684974; PMCID: PMC3676707.
    114. Golfetto O, Hinde E, Gratton E. Laurdan fluorescence lifetime discriminates cholesterol content from changes in fluidity in living cell membranes. Biophys J. 2013 Mar 19; 104(6):1238-47. PMID: 23528083; PMCID: PMC3602759.
    115. Andrews LM, Jones MR, Digman MA, Gratton E. Detecting Pyronin Y labeled RNA transcripts in live cell microenvironments by phasor-FLIM analysis. Methods Appl Fluoresc. 2013 Mar 01; 1(1):015001. PMID: 24563776.
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    116. Krasieva TB, Stringari C, Liu F, Sun CH, Kong Y, Balu M, Meyskens FL, Gratton E, Tromberg BJ. Two-photon excited fluorescence lifetime imaging and spectroscopy of melanins in vitro and in vivo. J Biomed Opt. 2013 Mar; 18(3):31107. PMID: 23235925; PMCID: PMC3595716.
    117. Coppola S, Cardarelli F, Pozzi D, Estrada LC, Digman MA, Gratton E, Bifone A, Marianecci C, Caracciolo G. The role of cytoskeleton networks on lipid-mediated delivery of DNA. Ther Deliv. 2013 Feb; 4(2):191-202. PMID: 23343159; PMCID: PMC3771858.
    118. Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL. IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 2013 Jan; 9(1):e1003124. PMID: 23358889; PMCID: PMC3554583.
    119. Dobrinskikh E, Lanzano L, Rachelson J, Cranston D, Moldovan R, Lei T, Gratton E, Doctor RB. Shank2 contributes to the apical retention and intracellular redistribution of NaPiIIa in OK cells. Am J Physiol Cell Physiol. 2013 Mar; 304(6):C561-73. PMID: 23325414; PMCID: PMC3674434.
    120. Chen H, Gratton E. A practical implementation of multifrequency widefield frequency-domain fluorescence lifetime imaging microscopy. Microsc Res Tech. 2013 Mar; 76(3):282-9. PMID: 23296945; PMCID: PMC3742114.
    121. Adu-Gyamfi E, Soni SP, Xue Y, Digman MA, Gratton E, Stahelin RV. The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress. J Biol Chem. 2013 Feb 22; 288(8):5779-89. PMID: 23297401; PMCID: PMC3581432.
    122. Digman MA, Stakic M, Gratton E. Raster image correlation spectroscopy and number and brightness analysis. Methods Enzymol. 2013; 518:121-44. PMID: 23276538.
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    123. Leproux A, Durkin A, Compton M, Cerussi AE, Gratton E, Tromberg BJ. Assessing tumor contrast in radiographically dense breast tissue using Diffuse Optical Spectroscopic Imaging (DOSI). Breast Cancer Res. 2013; 15(5):R89. PMID: 24066941; PMCID: PMC3979060.
    124. Cutrale F, Salih A, Gratton E. Spectral Phasor approach for fingerprinting of photo-activatable fluorescent proteins Dronpa, Kaede and KikGR. Methods Appl Fluoresc. 2013; 1(3):35001. PMID: 24040513.
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    125. Hinde E, Cardarelli F, Chen A, Khine M, Gratton E. Tracking the mechanical dynamics of human embryonic stem cell chromatin. Epigenetics Chromatin. 2012 Dec 21; 5(1):20. PMID: 23259580; PMCID: PMC3570407.
    126. Andrews LM, Jones MR, Digman MA, Gratton E. Spectral phasor analysis of Pyronin Y labeled RNA microenvironments in living cells. Biomed Opt Express. 2013 Jan 01; 4(1):171-7. PMID: 23304656; PMCID: PMC3539199.
    127. Hinde E, Digman MA, Hahn KM, Gratton E. Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):135-40. PMID: 23248275; PMCID: PMC3538204.
    128. Torno K, Wright BK, Jones MR, Digman MA, Gratton E, Phillips M. Real-time analysis of metabolic activity within Lactobacillus acidophilus by phasor fluorescence lifetime imaging microscopy of NADH. Curr Microbiol. 2013 Apr; 66(4):365-7. PMID: 23233088.
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    129. Wigal SB, Polzonetti CM, Stehli A, Gratton E. Phase synchronization of oxygenation waves in the frontal areas of children with attention-deficit hyperactivity disorder detected by optical diffusion spectroscopy correlates with medication. J Biomed Opt. 2012 Dec; 17(12):127002. PMID: 23232795; PMCID: PMC3518849.
    130. Whiteside MD, Digman MA, Gratton E, Treseder KK. Organic nitrogen uptake by arbuscular mycorrhizal fungi in a boreal forest. Soil Biol Biochem. 2012 Dec; 55. PMID: 24371363.
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    131. Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein. Biophys J. 2012 Nov 07; 103(9):L41-3. PMID: 23199932; PMCID: PMC3491695.
    132. Stringari C, Nourse JL, Flanagan LA, Gratton E. Phasor fluorescence lifetime microscopy of free and protein-bound NADH reveals neural stem cell differentiation potential. PLoS One. 2012; 7(11):e48014. PMID: 23144844; PMCID: PMC3489895.
    133. Crosignani V, Dvornikov A, Aguilar JS, Stringari C, Edwards R, Mantulin WW, Gratton E. Deep tissue fluorescence imaging and in vivo biological applications. J Biomed Opt. 2012 Nov; 17(11):116023. PMID: 23214184; PMCID: PMC3494495.
    134. Wright BK, Andrews LM, Jones MR, Stringari C, Digman MA, Gratton E. Phasor-FLIM analysis of NADH distribution and localization in the nucleus of live progenitor myoblast cells. Microsc Res Tech. 2012 Dec; 75(12):1717-22. PMID: 23019116; PMCID: PMC3635844.
    135. Arnesano C, Santoro Y, Gratton E. Digital parallel frequency-domain spectroscopy for tissue imaging. J Biomed Opt. 2012 Sep; 17(9):96014-1. PMID: 23085915; PMCID: PMC3442105.
    136. Giral H, Cranston D, Lanzano L, Caldas Y, Sutherland E, Rachelson J, Dobrinskikh E, Weinman EJ, Doctor RB, Gratton E, Levi M. NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. J Biol Chem. 2012 Oct 12; 287(42):35047-56. PMID: 22904329; PMCID: PMC3471691.
    137. Coppola S, Estrada LC, Digman MA, Pozzi D, Cardarelli F, Gratton E, Caracciolo G. Intracellular trafficking of cationic liposome-DNA complexes in living cells. Soft Matter. 2012 Aug 14; 8(30):7919-7927. PMID: 25152766.
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    138. Stringari C, Edwards RA, Pate KT, Waterman ML, Donovan PJ, Gratton E. Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH. Sci Rep. 2012; 2:568. PMID: 22891156; PMCID: PMC3416911.
    139. Wright BK, Andrews LM, Markham J, Jones MR, Stringari C, Digman MA, Gratton E. NADH distribution in live progenitor stem cells by phasor-fluorescence lifetime image microscopy. Biophys J. 2012 Jul 03; 103(1):L7-9. PMID: 22828352; PMCID: PMC3388207.
    140. Cutrale F, Gratton E. Inclined selective plane illumination microscopy adaptor for conventional microscopes. Microsc Res Tech. 2012 Nov; 75(11):1461-6. PMID: 22736488; PMCID: PMC3742098.
    141. Adu-Gyamfi E, Digman MA, Gratton E, Stahelin RV. Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis. Biophys J. 2012 Jun 06; 102(11):2517-25. PMID: 22713567; PMCID: PMC3368128.
    142. James NG, Digman MA, Gratton E, Barylko B, Ding X, Albanesi JP, Goldberg MS, Jameson DM. Number and brightness analysis of LRRK2 oligomerization in live cells. Biophys J. 2012 Jun 06; 102(11):L41-3. PMID: 22713584; PMCID: PMC3368136.
    143. Cardarelli F, Lanzano L, Gratton E. Capturing directed molecular motion in the nuclear pore complex of live cells. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9863-8. PMID: 22665783; PMCID: PMC3382504.
    144. Sanchez SA, Tricerri MA, Gratton E. Laurdan generalized polarization fluctuations measures membrane packing micro-heterogeneity in vivo. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7314-9. PMID: 22529342; PMCID: PMC3358851.
    145. Battisti A, Digman MA, Gratton E, Storti B, Beltram F, Bizzarri R. Intracellular pH measurements made simple by fluorescent protein probes and the phasor approach to fluorescence lifetime imaging. Chem Commun (Camb). 2012 May 25; 48(42):5127-9. PMID: 22517076; PMCID: PMC3742097.
    146. Lanzano L, Gratton E. Measurement of distance with the nanoscale precise imaging by rapid beam oscillation method. Microsc Res Tech. 2012 Sep; 75(9):1253-64. PMID: 22514034; PMCID: PMC3426651.
    147. Stringari C, Sierra R, Donovan PJ, Gratton E. Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy. J Biomed Opt. 2012 Apr; 17(4):046012. PMID: 22559690; PMCID: PMC3381030.
    148. Zhou S, Lo WC, Suhalim JL, Digman MA, Gratton E, Nie Q, Lander AD. Free extracellular diffusion creates the Dpp morphogen gradient of the Drosophila wing disc. Curr Biol. 2012 Apr 24; 22(8):668-75. PMID: 22445299; PMCID: PMC3338872.
    149. Digman MA, Gratton E. Scanning image correlation spectroscopy. Bioessays. 2012 May; 34(5):377-85. PMID: 22415853; PMCID: PMC3635842.
    150. Hinde E, Cardarelli F, Digman MA, Gratton E. Changes in chromatin compaction during the cell cycle revealed by micrometer-scale measurement of molecular flow in the nucleus. Biophys J. 2012 Feb 08; 102(3):691-7. PMID: 22325293; PMCID: PMC3274830.
    151. Estrada LC, Gratton E. Spectroscopic properties of gold nanoparticles at the single-particle level in biological environments. Chemphyschem. 2012 Mar; 13(4):1087-92. PMID: 22298327; PMCID: PMC4245151.
    152. Kniazeva E, Weidling JW, Singh R, Botvinick EL, Digman MA, Gratton E, Putnam AJ. Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D. Integr Biol (Camb). 2012 Apr; 4(4):431-9. PMID: 22281872; PMCID: PMC3771856.
    153. Sanchez SA, Gratton E, Zanocco AL, Lemp E, Gunther G. Sucrose monoester micelles size determined by Fluorescence Correlation Spectroscopy (FCS). PLoS One. 2011; 6(12):e29278. PMID: 22216230; PMCID: PMC3247245.
    154. Stafford RL, Hinde E, Knight MJ, Pennella MA, Ear J, Digman MA, Gratton E, Bowie JU. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Structure. 2011 Dec 07; 19(12):1826-36. PMID: 22153505; PMCID: PMC3240820.
    155. Leproux A, Cerussi AE, Tanamai W, Durkin AF, Compton M, Gratton E, Tromberg BJ. Impact of contralateral and ipsilateral reference tissue selection on self-referencing differential spectroscopy for breast cancer detection. J Biomed Opt. 2011 Nov; 16(11):116019. PMID: 22112124; PMCID: PMC3223514.
    156. Estrada LC, Gratton E. 3D nanometer images of biological fibers by directed motion of gold nanoparticles. Nano Lett. 2011 Nov 09; 11(11):4656-60. PMID: 21919444; PMCID: PMC3220937.
    157. Santoro Y, Leproux A, Cerussi A, Tromberg B, Gratton E. Breast cancer spatial heterogeneity in near-infrared spectra and the prediction of neoadjuvant chemotherapy response. J Biomed Opt. 2011 Sep; 16(9):097007. PMID: 21950942; PMCID: PMC3203125.
    158. Hinde E, Digman MA, Welch C, Hahn KM, Gratton E. Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microsc Res Tech. 2012 Mar; 75(3):271-81. PMID: 21858900; PMCID: PMC3523109.
    159. Cardarelli F, Lanzano L, Gratton E. Fluorescence correlation spectroscopy of intact nuclear pore complexes. Biophys J. 2011 Aug 17; 101(4):L27-9. PMID: 21843462; PMCID: PMC3175086.
    160. Wolf U, Toronov V, Choi JH, Gupta R, Michalos A, Gratton E, Wolf M. Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry. J Biomed Opt. 2011 Aug; 16(8):087013. PMID: 21895340; PMCID: PMC3170400.
    161. Stringari C, Cinquin A, Cinquin O, Digman MA, Donovan PJ, Gratton E. Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13582-7. PMID: 21808026; PMCID: PMC3158156.
    162. Sanchez S, Bakás L, Gratton E, Herlax V. Alpha hemolysin induces an increase of erythrocytes calcium: a FLIM 2-photon phasor analysis approach. PLoS One. 2011; 6(6):e21127. PMID: 21698153; PMCID: PMC3116868.
    163. Itano MS, Neumann AK, Liu P, Zhang F, Gratton E, Parak WJ, Thompson NL, Jacobson K. DC-SIGN and influenza hemagglutinin dynamics in plasma membrane microdomains are markedly different. Biophys J. 2011 Jun 08; 100(11):2662-70. PMID: 21641311; PMCID: PMC3117154.
    164. Caracciolo G, Pozzi D, Capriotti AL, Marianecci C, Carafa M, Marchini C, Montani M, Amici A, Amenitsch H, Digman MA, Gratton E, Sanchez SS, Laganà A. Factors determining the superior performance of lipid/DNA/protammine nanoparticles over lipoplexes. J Med Chem. 2011 Jun 23; 54(12):4160-71. PMID: 21615134.
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    165. Kotlarchyk MA, Shreim SG, Alvarez-Elizondo MB, Estrada LC, Singh R, Valdevit L, Kniazeva E, Gratton E, Putnam AJ, Botvinick EL. Concentration independent modulation of local micromechanics in a fibrin gel. PLoS One. 2011; 6(5):e20201. PMID: 21629793; PMCID: PMC3100350.
    166. Lanzano L, Lei T, Okamura K, Giral H, Caldas Y, Masihzadeh O, Gratton E, Levi M, Blaine J. Differential modulation of the molecular dynamics of the type IIa and IIc sodium phosphate cotransporters by parathyroid hormone. Am J Physiol Cell Physiol. 2011 Oct; 301(4):C850-61. PMID: 21593452; PMCID: PMC3191571.
    167. Sanchez SA, Gunther G, Tricerri MA, Gratton E. Methyl-ß-cyclodextrins preferentially remove cholesterol from the liquid disordered phase in giant unilamellar vesicles. J Membr Biol. 2011 May; 241(1):1-10. PMID: 21468650; PMCID: PMC3082695.
    168. Hinde E, Cardarelli F, Digman MA, Kershner A, Kimble J, Gratton E. The impact of mitotic versus interphase chromatin architecture on the molecular flow of EGFP by pair correlation analysis. Biophys J. 2011 Apr 06; 100(7):1829-36. PMID: 21463597; PMCID: PMC3072664.
    169. Lanzano L, Digman MA, Fwu P, Giral H, Levi M, Gratton E. Nanometer-scale imaging by the modulation tracking method. J Biophotonics. 2011 Jun; 4(6):415-24. PMID: 21462350; PMCID: PMC3393040.
    170. Azartash K, Kwan J, Paugh JR, Nguyen AL, Jester JV, Gratton E. Pre-corneal tear film thickness in humans measured with a novel technique. Mol Vis. 2011 Mar 22; 17:756-67. PMID: 21527997; PMCID: PMC3081798.
    171. Crosignani V, Dvornikov AS, Gratton E. Enhancement of imaging depth in turbid media using a wide area detector. J Biophotonics. 2011 Sep; 4(9):592-9. PMID: 21425242; PMCID: PMC4245154.
    172. Giral H, Lanzano L, Caldas Y, Blaine J, Verlander JW, Lei T, Gratton E, Levi M. Role of PDZK1 protein in apical membrane expression of renal sodium-coupled phosphate transporters. J Biol Chem. 2011 Apr 29; 286(17):15032-42. PMID: 21388960; PMCID: PMC3083164.
    173. Blaine J, Lanzano L, Giral H, Caldas Y, Levi M, Gratton E, Moldovan R, Lei T. Dynamic imaging of the sodium phosphate cotransporters. Adv Chronic Kidney Dis. 2011 Mar; 18(2):145-50. PMID: 21406299; PMCID: PMC3220941.
    174. Gratton E. Applied physics. Deeper tissue imaging with total detection. Science. 2011 Feb 25; 331(6020):1016-7. PMID: 21350154.
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    175. Chen B, Estrada LC, Hellriegel C, Gratton E. Nanometer-scale optical imaging of collagen fibers using gold nanoparticles. Biomed Opt Express. 2011 Feb 07; 2(3):511-9. PMID: 21412457; PMCID: PMC3047357.
    176. Choi CK, Zareno J, Digman MA, Gratton E, Horwitz AR. Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesions. Biophys J. 2011 Feb 02; 100(3):583-592. PMID: 21281572.
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    177. Ross JA, Digman MA, Wang L, Gratton E, Albanesi JP, Jameson DM. Oligomerization state of dynamin 2 in cell membranes using TIRF and number and brightness analysis. Biophys J. 2011 Feb 02; 100(3):L15-L17. PMID: 21281565.
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    178. Digman MA, Gratton E. Lessons in fluctuation correlation spectroscopy. Annu Rev Phys Chem. 2011; 62:645-68. PMID: 21219151; PMCID: PMC3576135.
    179. Behne MJ, Sanchez S, Barry NP, Kirschner N, Meyer W, Mauro TM, Moll I, Gratton E. Major translocation of calcium upon epidermal barrier insult: imaging and quantification via FLIM/Fourier vector analysis. Arch Dermatol Res. 2011 Mar; 303(2):103-15. PMID: 21193994; PMCID: PMC4548958.
    180. Kim SA, Sanabria H, Digman MA, Gratton E, Schwille P, Zipfel WR, Waxham MN. Quantifying translational mobility in neurons: comparison between current optical techniques. J Neurosci. 2010 Dec 08; 30(49):16409-16. PMID: 21147979; PMCID: PMC3003925.
    181. Rossow MJ, Sasaki JM, Digman MA, Gratton E. Raster image correlation spectroscopy in live cells. Nat Protoc. 2010 Nov; 5(11):1761-74. PMID: 21030952; PMCID: PMC3089972.
    182. Azartash K, Shy CJ, Flynn K, Jester JV, Gratton E. Non-invasive in vivo measurement of the tear film using spatial autocorrelation in a live mammal model. Biomed Opt Express. 2010 Oct 08; 1(4):1127-1137. PMID: 21258535.
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    183. Hinde E, Cardarelli F, Digman MA, Gratton E. In vivo pair correlation analysis of EGFP intranuclear diffusion reveals DNA-dependent molecular flow. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16560-5. PMID: 20823232; PMCID: PMC2944750.
    184. Moens PD, Gratton E, Salvemini IL. Fluorescence correlation spectroscopy, raster image correlation spectroscopy, and number and brightness on a commercial confocal laser scanning microscope with analog detectors (Nikon C1). Microsc Res Tech. 2011 Apr; 74(4):377-88. PMID: 20734406.
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    185. Ossato G, Digman MA, Aiken C, Lukacsovich T, Marsh JL, Gratton E. A two-step path to inclusion formation of huntingtin peptides revealed by number and brightness analysis. Biophys J. 2010 Jun 16; 98(12):3078-85. PMID: 20550921; PMCID: PMC2884247.
    186. Cardarelli F, Gratton E. In vivo imaging of single-molecule translocation through nuclear pore complexes by pair correlation functions. PLoS One. 2010 May 03; 5(5):e10475. PMID: 20454622; PMCID: PMC2862743.
    187. Sánchez SA, Tricerri MA, Ossato G, Gratton E. Lipid packing determines protein-membrane interactions: challenges for apolipoprotein A-I and high density lipoproteins. Biochim Biophys Acta. 2010 Jul; 1798(7):1399-408. PMID: 20347719; PMCID: PMC2883020.
    188. Rossow MJ, Mantulin WW, Gratton E. Scanning laser image correlation for measurement of flow. J Biomed Opt. 2010 Mar-Apr; 15(2):026003. PMID: 20459248; PMCID: PMC2869368.
    189. Kukreti S, Cerussi AE, Tanamai W, Hsiang D, Tromberg BJ, Gratton E. Characterization of metabolic differences between benign and malignant tumors: high-spectral-resolution diffuse optical spectroscopy. Radiology. 2010 Jan; 254(1):277-84. PMID: 20032159; PMCID: PMC2797652.
    190. Celli A, Gratton E. Dynamics of lipid domain formation: fluctuation analysis. Biochim Biophys Acta. 2010 Jul; 1798(7):1368-76. PMID: 20025848; PMCID: PMC2883005.
    191. Yoon Y, Tong J, Lee PJ, Albanese A, Bhardwaj N, Källberg M, Digman MA, Lu H, Gratton E, Shin YK, Cho W. Molecular basis of the potent membrane-remodeling activity of the epsin 1 N-terminal homology domain. J Biol Chem. 2010 Jan 01; 285(1):531-40. PMID: 19880963; PMCID: PMC2804201.
    192. Tanner K, Ferris DR, Lanzano L, Mandefro B, Mantulin WW, Gardiner DM, Rugg EL, Gratton E. Coherent movement of cell layers during wound healing by image correlation spectroscopy. Biophys J. 2009 Oct 07; 97(7):2098-106. PMID: 19804742; PMCID: PMC2756390.
    193. Katayama Y, Burkacky O, Meyer M, Bräuchle C, Gratton E, Lamb DC. Real-time nanomicroscopy via three-dimensional single-particle tracking. Chemphyschem. 2009 Oct 05; 10(14):2458-64. PMID: 19760694; PMCID: PMC2857558.
    194. Digman MA, Gratton E. Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct; 1(2):273-282. PMID: 20835996.
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    195. Digman MA, Gratton E. Imaging barriers to diffusion by pair correlation functions. Biophys J. 2009 Jul 22; 97(2):665-73. PMID: 19619481; PMCID: PMC2711318.
    196. Krishnan K, Holub O, Gratton E, Clayton AH, Cody S, Moens PD. Profilin interaction with phosphatidylinositol (4,5)-bisphosphate destabilizes the membrane of giant unilamellar vesicles. Biophys J. 2009 Jun 17; 96(12):5112-21. PMID: 19527671; PMCID: PMC2712054.
    197. Gielen E, Smisdom N, vandeVen M, De Clercq B, Gratton E, Digman M, Rigo JM, Hofkens J, Engelborghs Y, Ameloot M. Measuring diffusion of lipid-like probes in artificial and natural membranes by raster image correlation spectroscopy (RICS): use of a commercial laser-scanning microscope with analog detection. Langmuir. 2009 May 05; 25(9):5209-18. PMID: 19260653; PMCID: PMC2728053.
    198. Caracciolo G, Caminiti R, Digman MA, Gratton E, Sanchez S. Efficient escape from endosomes determines the superior efficiency of multicomponent lipoplexes. J Phys Chem B. 2009 Apr 16; 113(15):4995-7. PMID: 19301832; PMCID: PMC2673460.
    199. Digman MA, Gratton E. Analysis of diffusion and binding in cells using the RICS approach. Microsc Res Tech. 2009 Apr; 72(4):323-32. PMID: 19067357; PMCID: PMC4364519.
    200. Rossow M, Mantulin WW, Gratton E. Spatiotemporal image correlation spectroscopy measurements of flow demonstrated in microfluidic channels. J Biomed Opt. 2009 Mar-Apr; 14(2):024014. PMID: 19405744; PMCID: PMC2702990.
    201. Hellriegel C, Gratton E. Real-time multi-parameter spectroscopy and localization in three-dimensional single-particle tracking. J R Soc Interface. 2009 Feb 06; 6 Suppl 1:S3-14. PMID: 18753123; PMCID: PMC2706464.
    202. Gratton E, Digman M. One photon up, one photon down. Nat Biotechnol. 2009 Feb; 27(2):147-8. PMID: 19204693.
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    203. Digman MA, Wiseman PW, Choi C, Horwitz AR, Gratton E. Stoichiometry of molecular complexes at adhesions in living cells. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2170-5. PMID: 19168634; PMCID: PMC2630200.
    204. Digman MA, Wiseman PW, Horwitz AR, Gratton E. Detecting protein complexes in living cells from laser scanning confocal image sequences by the cross correlation raster image spectroscopy method. Biophys J. 2009 Jan; 96(2):707-16. PMID: 19167315; PMCID: PMC2716688.
    205. Barreiro O, Zamai M, Yáñez-Mó M, Tejera E, López-Romero P, Monk PN, Gratton E, Caiolfa VR, Sánchez-Madrid F. Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms. J Cell Biol. 2008 Nov 03; 183(3):527-42. PMID: 18955551; PMCID: PMC2575792.
    206. Sanabria H, Digman MA, Gratton E, Waxham MN. Spatial diffusivity and availability of intracellular calmodulin. Biophys J. 2008 Dec 15; 95(12):6002-15. PMID: 18820232; PMCID: PMC2599858.
    207. Unruh JR, Gratton E. Analysis of molecular concentration and brightness from fluorescence fluctuation data with an electron multiplied CCD camera. Biophys J. 2008 Dec; 95(11):5385-98. PMID: 18805922; PMCID: PMC2586556.
    208. Malengo G, Andolfo A, Sidenius N, Gratton E, Zamai M, Caiolfa VR. Fluorescence correlation spectroscopy and photon counting histogram on membrane proteins: functional dynamics of the glycosylphosphatidylinositol-anchored urokinase plasminogen activator receptor. J Biomed Opt. 2008 May-Jun; 13(3):031215. PMID: 18601539; PMCID: PMC2718687.
    209. Colyer RA, Lee C, Gratton E. A novel fluorescence lifetime imaging system that optimizes photon efficiency. Microsc Res Tech. 2008 Mar; 71(3):201-13. PMID: 18008362.
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    210. Kwok S, Lee C, Sánchez SA, Hazlett TL, Gratton E, Hayashi Y. Genetically encoded probe for fluorescence lifetime imaging of CaMKII activity. Biochem Biophys Res Commun. 2008 May 02; 369(2):519-25. PMID: 18302935; PMCID: PMC2396457.
    211. Kukreti S, Cerussi A, Tromberg B, Gratton E. Intrinsic near-infrared spectroscopic markers of breast tumors. Dis Markers. 2008; 25(6):281-90. PMID: 19208946; PMCID: PMC2732199.
    212. Dalal RB, Digman MA, Horwitz AF, Vetri V, Gratton E. Determination of particle number and brightness using a laser scanning confocal microscope operating in the analog mode. Microsc Res Tech. 2008 Jan; 71(1):69-81. PMID: 17937391.
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    213. Levi V, Gratton E. Chromatin dynamics during interphase explored by single-particle tracking. Chromosome Res. 2008; 16(3):439-49. PMID: 18461483; PMCID: PMC2701671.
    214. Fiorini R, Ragni L, Ambrosi S, Littarru GP, Gratton E, Hazlett T. Fluorescence studies of the interactions of ubiquinol-10 with liposomes. Photochem Photobiol. 2008 Jan-Feb; 84(1):209-14. PMID: 18173722.
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    215. Digman MA, Dalal R, Horwitz AF, Gratton E. Mapping the number of molecules and brightness in the laser scanning microscope. Biophys J. 2008 Mar 15; 94(6):2320-32. PMID: 18096627; PMCID: PMC2257897.
    216. García-Marcos A, Sánchez SA, Parada P, Eid J, Jameson DM, Remacha M, Gratton E, Ballesta JP. Yeast ribosomal stalk heterogeneity in vivo shown by two-photon FCS and molecular brightness analysis. Biophys J. 2008 Apr 01; 94(7):2884-90. PMID: 18096629; PMCID: PMC2267128.
    217. Raub CB, Unruh J, Suresh V, Krasieva T, Lindmo T, Gratton E, Tromberg BJ, George SC. Image correlation spectroscopy of multiphoton images correlates with collagen mechanical properties. Biophys J. 2008 Mar 15; 94(6):2361-73. PMID: 18065452; PMCID: PMC2257909.
    218. Caiolfa VR, Zamai M, Malengo G, Andolfo A, Madsen CD, Sutin J, Digman MA, Gratton E, Blasi F, Sidenius N. Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies. J Cell Biol. 2007 Dec 03; 179(5):1067-82. PMID: 18056417; PMCID: PMC2099195.
    219. Olopade CO, Mensah E, Gupta R, Huo D, Picchietti DL, Gratton E, Michalos A. Noninvasive determination of brain tissue oxygenation during sleep in obstructive sleep apnea: a near-infrared spectroscopic approach. Sleep. 2007 Dec; 30(12):1747-55. PMID: 18246984; PMCID: PMC2276122.
    220. Digman MA, Brown CM, Horwitz AR, Mantulin WW, Gratton E. Paxillin dynamics measured during adhesion assembly and disassembly by correlation spectroscopy. Biophys J. 2008 Apr 01; 94(7):2819-31. PMID: 17993500; PMCID: PMC2267137.
    221. Digman MA, Caiolfa VR, Zamai M, Gratton E. The phasor approach to fluorescence lifetime imaging analysis. Biophys J. 2008 Jan 15; 94(2):L14-6. PMID: 17981902; PMCID: PMC2157251.
    222. Wolf U, Wolf M, Choi JH, Paunescu LA, Michalos A, Gratton E. Regional differences of hemodynamics and oxygenation in the human calf muscle detected with near-infrared spectrophotometry. J Vasc Interv Radiol. 2007 Sep; 18(9):1094-101. PMID: 17804770.
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    223. Celli A, Beretta S, Gratton E. Phase fluctuations on the micron-submicron scale in GUVs composed of a binary lipid mixture. Biophys J. 2008 Jan 01; 94(1):104-16. PMID: 17766332; PMCID: PMC2134868.
    224. Sanchez SA, Tricerri MA, Gratton E. Interaction of high density lipoprotein particles with membranes containing cholesterol. J Lipid Res. 2007 Aug; 48(8):1689-700. PMID: 17485728.
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    225. Gatto R, Hoffman W, Paisansathan C, Mantulin W, Gratton E, Charbel FT. Effect of age on brain oxygenation regulation during changes in position. J Neurosci Methods. 2007 Aug 30; 164(2):308-11. PMID: 17561266.
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    226. Kukreti S, Cerussi A, Tromberg B, Gratton E. Intrinsic tumor biomarkers revealed by novel double-differential spectroscopic analysis of near-infrared spectra. J Biomed Opt. 2007 Mar-Apr; 12(2):020509. PMID: 17477706.
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    227. Boens N, Qin W, Basaric N, Hofkens J, Ameloot M, Pouget J, Lefèvre JP, Valeur B, Gratton E, vandeVen M, Silva ND, Engelborghs Y, Willaert K, Sillen A, Rumbles G, Phillips D, Visser AJ, van Hoek A, Lakowicz JR, Malak H, Gryczynski I, Szabo AG, Krajcarski DT, Tamai N, Miura A. Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy. Anal Chem. 2007 Mar 01; 79(5):2137-49. PMID: 17269654.
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    228. Calderon-Arnulphi M, Alaraj A, Amin-Hanjani S, Mantulin WW, Polzonetti CM, Gratton E, Charbel FT. Detection of cerebral ischemia in neurovascular surgery using quantitative frequency-domain near-infrared spectroscopy. J Neurosurg. 2007 Feb; 106(2):283-90. PMID: 17410713.
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    229. Celli A, Lee CY, Gratton E. Fluorescence microscopy to study pressure between lipids in giant unilamellar vesicles. Methods Mol Biol. 2007; 400:333-9. PMID: 17951744.
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    230. Levi V, Gratton E. Exploring dynamics in living cells by tracking single particles. Cell Biochem Biophys. 2007; 48(1):1-15. PMID: 17703064.
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    231. Tanner K, Beitel E, D'Amico E, Mantulin WW, Gratton E. Effects of vasodilation on intrinsic optical signals in the mammalian brain: a phantom study. J Biomed Opt. 2006 Nov-Dec; 11(6):064020. PMID: 17212543.
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    232. Eckhoff DA, Stuart JN, Sutin JD, Sweedler JV, Gratton E. Capillary electrophoresis of ultrasmall carboxylate functionalized silicon nanoparticles. J Chem Phys. 2006 Aug 28; 125(8):081103. PMID: 16964993.
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    233. Nicolini C, Celli A, Gratton E, Winter R. Pressure tuning of the morphology of heterogeneous lipid vesicles: a two-photon-excitation fluorescence microscopy study. Biophys J. 2006 Oct 15; 91(8):2936-42. PMID: 16877511; PMCID: PMC1578477.
    234. Hanson KM, Gratton E, Bardeen CJ. Sunscreen enhancement of UV-induced reactive oxygen species in the skin. Free Radic Biol Med. 2006 Oct 15; 41(8):1205-12. PMID: 17015167.
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    235. Ragan T, Huang H, So P, Gratton E. 3D particle tracking on a two-photon microscope. J Fluoresc. 2006 May; 16(3):325-36. PMID: 16544202.
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    236. Nicolini C, Baranski J, Schlummer S, Palomo J, Lumbierres-Burgues M, Kahms M, Kuhlmann J, Sanchez S, Gratton E, Waldmann H, Winter R. Visualizing association of N-ras in lipid microdomains: influence of domain structure and interfacial adsorption. J Am Chem Soc. 2006 Jan 11; 128(1):192-201. PMID: 16390147.
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    237. Simonson P, D'Amico E, Gratton E. Modulation of an optical needle's reflectivity alters the average photon path through scattering media. J Biomed Opt. 2006 Jan-Feb; 11(1):014023. PMID: 16526900.
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    238. Levi V, Gelfand VI, Serpinskaya AS, Gratton E. Melanosomes transported by myosin-V in Xenopus melanophores perform slow 35 nm steps. Biophys J. 2006 Jan 01; 90(1):L07-9. PMID: 16284273; PMCID: PMC1367043.
    239. Tanner K, D'Amico E, Kaczmarowski A, Kukreti S, Malpeli J, Mantulin WW, Gratton E. Spectrally resolved neurophotonics: a case report of hemodynamics and vascular components in the mammalian brain. J Biomed Opt. 2005 Nov-Dec; 10(6):064009. PMID: 16409074.
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    240. Eckhoff DA, Sutin JD, Clegg RM, Gratton E, Rogozhina EV, Braun PV. Optical characterization of ultrasmall Si nanoparticles prepared through electrochemical dispersion of bulk Si. J Phys Chem B. 2005 Oct 27; 109(42):19786-97. PMID: 16853559.
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    241. Gokhale NA, Abraham A, Digman MA, Gratton E, Cho W. Phosphoinositide specificity of and mechanism of lipid domain formation by annexin A2-p11 heterotetramer. J Biol Chem. 2005 Dec 30; 280(52):42831-40. PMID: 16230353.
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    242. Levi V, Serpinskaya AS, Gratton E, Gelfand V. Organelle transport along microtubules in Xenopus melanophores: evidence for cooperation between multiple motors. Biophys J. 2006 Jan 01; 90(1):318-27. PMID: 16214870; PMCID: PMC1367030.
    243. Levi V, Ruan Q, Plutz M, Belmont AS, Gratton E. Chromatin dynamics in interphase cells revealed by tracking in a two-photon excitation microscope. Biophys J. 2005 Dec; 89(6):4275-85. PMID: 16150965; PMCID: PMC1366992.
    244. Sánchez SA, Gratton E. Lipid--protein interactions revealed by two-photon microscopy and fluorescence correlation spectroscopy. Acc Chem Res. 2005 Jun; 38(6):469-77. PMID: 15966713.
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    245. Digman MA, Brown CM, Sengupta P, Wiseman PW, Horwitz AR, Gratton E. Measuring fast dynamics in solutions and cells with a laser scanning microscope. Biophys J. 2005 Aug; 89(2):1317-27. PMID: 15908582; PMCID: PMC1366616.
    246. Arnulphi C, Sánchez SA, Tricerri MA, Gratton E, Jonas A. Interaction of human apolipoprotein A-I with model membranes exhibiting lipid domains. Biophys J. 2005 Jul; 89(1):285-95. PMID: 15849246; PMCID: PMC1366526.
    247. Digman MA, Sengupta P, Wiseman PW, Brown CM, Horwitz AR, Gratton E. Fluctuation correlation spectroscopy with a laser-scanning microscope: exploiting the hidden time structure. Biophys J. 2005 May; 88(5):L33-6. PMID: 15792971; PMCID: PMC1305524.
    248. Tricerri MA, Toledo JD, Sanchez SA, Hazlett TL, Gratton E, Jonas A, Garda HA. Visualization and analysis of apolipoprotein A-I interaction with binary phospholipid bilayers. J Lipid Res. 2005 Apr; 46(4):669-78. PMID: 15654128.
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    249. Levi V, Ruan Q, Gratton E. 3-D particle tracking in a two-photon microscope: application to the study of molecular dynamics in cells. Biophys J. 2005 Apr; 88(4):2919-28. PMID: 15653748; PMCID: PMC1305386.
    250. Gratton E, Toronov V, Wolf U, Wolf M, Webb A. Measurement of brain activity by near-infrared light. J Biomed Opt. 2005 Jan-Feb; 10(1):11008. PMID: 15847574.
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    251. Safonova LP, Michalos A, Wolf U, Wolf M, Hueber DM, Choi JH, Gupta R, Polzonetti C, Mantulin WW, Gratton E. Age-correlated changes in cerebral hemodynamics assessed by near-infrared spectroscopy. Arch Gerontol Geriatr. 2004 Nov-Dec; 39(3):207-25. PMID: 15381340.
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    252. Barcellona ML, Gammon S, Hazlett T, Digman MA, Gratton E. Polarized fluorescence correlation spectroscopy of DNA-DAPI complexes. Microsc Res Tech. 2004 Nov; 65(4-5):205-17. PMID: 15630690.
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    253. Masters BR, So PT, Buehler C, Barry N, Sutin JD, Mantulin WW, Gratton E. Mitigating thermal mechanical damage potential during two-photon dermal imaging. J Biomed Opt. 2004 Nov-Dec; 9(6):1265-70. PMID: 15568947.
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    254. Inoue M, Digman MA, Cheng M, Breusegem SY, Halaihel N, Sorribas V, Mantulin WW, Gratton E, Barry NP, Levi M. Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity. J Biol Chem. 2004 Nov 19; 279(47):49160-71. PMID: 15355967.
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    255. Ruan Q, Cheng MA, Levi M, Gratton E, Mantulin WW. Spatial-temporal studies of membrane dynamics: scanning fluorescence correlation spectroscopy (SFCS). Biophys J. 2004 Aug; 87(2):1260-7. PMID: 15298928; PMCID: PMC1304464.
    256. Janosch S, Nicolini C, Ludolph B, Peters C, Völkert M, Hazlet TL, Gratton E, Waldmann H, Winter R. Partitioning of dual-lipidated peptides into membrane microdomains: lipid sorting vs peptide aggregation. J Am Chem Soc. 2004 Jun 23; 126(24):7496-503. PMID: 15198596.
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    257. Kis-Petikova K, Gratton E. Distance measurement by circular scanning of the excitation beam in the two-photon microscope. Microsc Res Tech. 2004 Jan 01; 63(1):34-49. PMID: 14677132.
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    258. Choi J, Wolf M, Toronov V, Wolf U, Polzonetti C, Hueber D, Safonova LP, Gupta R, Michalos A, Mantulin W, Gratton E. Noninvasive determination of the optical properties of adult brain: near-infrared spectroscopy approach. J Biomed Opt. 2004 Jan-Feb; 9(1):221-9. PMID: 14715077.
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    259. Gaus K, Gratton E, Kable EP, Jones AS, Gelissen I, Kritharides L, Jessup W. Visualizing lipid structure and raft domains in living cells with two-photon microscopy. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15554-9. PMID: 14673117; PMCID: PMC307606.
    260. Toronov V, D'Amico E, Hueber D, Gratton E, Barbieri B, Webb A. Optimization of the signal-to-noise ratio of frequency-domain instrumentation for near-infrared spectro-imaging of the human brain. Opt Express. 2003 Oct 20; 11(21):2717-29. PMID: 19471386.
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    261. Müller JD, Gratton E. High-pressure fluorescence correlation spectroscopy. Biophys J. 2003 Oct; 85(4):2711-9. PMID: 14507734; PMCID: PMC1303495.
    262. Toronov V, Walker S, Gupta R, Choi JH, Gratton E, Hueber D, Webb A. The roles of changes in deoxyhemoglobin concentration and regional cerebral blood volume in the fMRI BOLD signal. Neuroimage. 2003 Aug; 19(4):1521-31. PMID: 12948708.
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    263. Gratton E, Breusegem S, Sutin J, Ruan Q, Barry N. Fluorescence lifetime imaging for the two-photon microscope: time-domain and frequency-domain methods. J Biomed Opt. 2003 Jul; 8(3):381-90. PMID: 12880343.
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    264. Wolf M, Wolf U, Choi JH, Toronov V, Paunescu LA, Michalos A, Gratton E. Fast cerebral functional signal in the 100-ms range detected in the visual cortex by frequency-domain near-infrared spectrophotometry. Psychophysiology. 2003 Jul; 40(4):521-8. PMID: 14570160.
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    265. Behne MJ, Barry NP, Hanson KM, Aronchik I, Clegg RW, Gratton E, Feingold K, Holleran WM, Elias PM, Mauro TM. Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. J Invest Dermatol. 2003 Jun; 120(6):998-1006. PMID: 12787127.
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    266. Wolf U, Wolf M, Choi JH, Levi M, Choudhury D, Hull S, Coussirat D, Paunescu LA, Safonova LP, Michalos A, Mantulin WW, Gratton E. Localized irregularities in hemoglobin flow and oxygenation in calf muscle in patients with peripheral vascular disease detected with near-infrared spectrophotometry. J Vasc Surg. 2003 May; 37(5):1017-26. PMID: 12756348.
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    267. Bagatolli LA, Sanchez SA, Hazlett T, Gratton E. Giant vesicles, Laurdan, and two-photon fluorescence microscopy: evidence of lipid lateral separation in bilayers. Methods Enzymol. 2003; 360:481-500. PMID: 12622164.
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    268. Zamai M, VandeVen M, Farao M, Gratton E, Ghiglieri A, Castelli MG, Fontana E, D'Argy R, Fiorino A, Pesenti E, Suarato A, Caiolfa VR. Camptothecin poly[n-(2-hydroxypropyl) methacrylamide] copolymers in antitopoisomerase-I tumor therapy: intratumor release and antitumor efficacy. Mol Cancer Ther. 2003 Jan; 2(1):29-40. PMID: 12533670.
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    269. Wolf M, Franceschini MA, Paunescu LA, Toronov V, Michalos A, Wolf U, Gratton E, Fantini S. Absolute frequency-domain pulse oximetry of the brain: methodology and measurements. Adv Exp Med Biol. 2003; 530:61-73. PMID: 14562705.
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    270. Wolf M, Wolf U, Choi JH, Gupta R, Safonova LP, Paunescu LA, Michalos A, Gratton E. Detection of the fast neuronal signal on the motor cortex using functional frequency domain near infrared spectroscopy. Adv Exp Med Biol. 2003; 510:193-7. PMID: 12580427.
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    271. Dong CY, French T, So PT, Buehler C, Berland KM, Gratton E. Fluorescence-lifetime imaging techniques for microscopy. Methods Cell Biol. 2003; 72:431-64. PMID: 14719344.
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    272. Wolf U, Wolf M, Choi JH, Paunescu LA, Safonova LP, Michalos A, Gratton E. Mapping of hemodynamics on the human calf with near infrared spectroscopy and the influence of the adipose tissue thickness. Adv Exp Med Biol. 2003; 510:225-30. PMID: 12580432.
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    273. Müller JD, Chen Y, Gratton E. Fluorescence correlation spectroscopy. Methods Enzymol. 2003; 361:69-92. PMID: 12624907.
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    274. Wolf M, Wolf U, Choi JH, Gupta R, Safonova LP, Paunescu LA, Michalos A, Gratton E. Functional frequency-domain near-infrared spectroscopy detects fast neuronal signal in the motor cortex. Neuroimage. 2002 Dec; 17(4):1868-75. PMID: 12498761.
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    275. Ruan Q, Chen Y, Gratton E, Glaser M, Mantulin WW. Cellular characterization of adenylate kinase and its isoform: two-photon excitation fluorescence imaging and fluorescence correlation spectroscopy. Biophys J. 2002 Dec; 83(6):3177-87. PMID: 12496087; PMCID: PMC1302395.
    276. Best KB, Ohran AJ, Hawes AC, Hazlett TL, Gratton E, Judd AM, Bell JD. Relationship between erythrocyte membrane phase properties and susceptibility to secretory phospholipase A2. Biochemistry. 2002 Nov 26; 41(47):13982-8. PMID: 12437355.
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    277. Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM. NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem. 2002 Dec 06; 277(49):47399-406. PMID: 12221084.
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    278. Hanson KM, Behne MJ, Barry NP, Mauro TM, Gratton E, Clegg RM. Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient. Biophys J. 2002 Sep; 83(3):1682-90. PMID: 12202391; PMCID: PMC1302264.
    279. Wolf M, Wolf U, Toronov V, Michalos A, Paunescu LA, Choi JH, Gratton E. Different time evolution of oxyhemoglobin and deoxyhemoglobin concentration changes in the visual and motor cortices during functional stimulation: a near-infrared spectroscopy study. Neuroimage. 2002 Jul; 16(3 Pt 1):704-12. PMID: 12169254.
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    280. Bettati S, Campanini B, Vaccari S, Mozzarelli A, Schianchi G, Hazlett TL, Gratton E, Benci S. Unfolding of pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase probed by time-resolved tryptophan fluorescence. Biochim Biophys Acta. 2002 Apr 01; 1596(1):47-54. PMID: 11983420.
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    281. Sanchez SA, Bagatolli LA, Gratton E, Hazlett TL. A two-photon view of an enzyme at work: Crotalus atrox venom PLA2 interaction with single-lipid and mixed-lipid giant unilamellar vesicles. Biophys J. 2002 Apr; 82(4):2232-43. PMID: 11916878; PMCID: PMC1302016.
    282. Patel RC, Kumar U, Lamb DC, Eid JS, Rocheville M, Grant M, Rani A, Hazlett T, Patel SC, Gratton E, Patel YC. Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3294-9. PMID: 11880655; PMCID: PMC122512.
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