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Botvinick, Elliot L

Title(s)Professor, Beckman Laser Institute
Phone(949) 824-9613
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    Collapse Research 
    Collapse Research Activities and Funding
    Multiphoton Microscope for Cardiovascular and Tissue Engineering
    NIH S10OD025064Aug 1, 2019 - Jul 31, 2020
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Thorson TJ, Gurlin RE, Botvinick EL, Mohraz A. Bijel-templated implantable biomaterials for enhancing tissue integration and vascularization. Acta Biomater. 2019 Jun 22. PMID: 31233892.
      View in: PubMed
    2. Hsieh JY, Keating MT, Smith TD, Meli VS, Botvinick EL, Liu WF. Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation. APL Bioeng. 2019 Mar; 3(1):016103. PMID: 31069336.
      View in: PubMed
    3. Keating M, Lim M, Hu Q, Botvinick E. Selective stiffening of fibrin hydrogels with micron resolution via photocrosslinking. Acta Biomater. 2019 Mar 15; 87:88-96. PMID: 30660778.
      View in: PubMed
    4. Hou J, Williams J, Botvinick EL, Potma EO, Tromberg BJ. Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State. Cancer Res. 2018 May 15; 78(10):2503-2512. PMID: 29535219.
      View in: PubMed
    5. Juliar BA, Keating MT, Kong YP, Botvinick EL, Putnam AJ. Sprouting angiogenesis induces significant mechanical heterogeneities and ECM stiffening across length scales in fibrin hydrogels. Biomaterials. 2018 04; 162:99-108. PMID: 29438884.
      View in: PubMed
    6. Thorson TJ, Botvinick EL, Mohraz A. Composite bijel-templated hydrogels for cell delivery. ACS Biomater Sci Eng. 2018 Feb 12; 4(2):587-594. PMID: 30555892.
      View in: PubMed
    7. Keating M, Kurup A, Alvarez-Elizondo M, Levine AJ, Botvinick E. Spatial distributions of pericellular stiffness in natural extracellular matrices are dependent on cell-mediated proteolysis and contractility. Acta Biomater. 2017 07 15; 57:304-312. PMID: 28483696.
      View in: PubMed
    8. Gurlin RE, Keating MT, Li S, Lakey JR, de Feraudy S, Shergill BS, Botvinick EL. Vascularization and innervation of slits within polydimethylsiloxane sheets in the subcutaneous space of athymic nude mice. J Tissue Eng. 2017 Jan-Dec; 8:2041731417691645. PMID: 28228933.
      View in: PubMed
    9. Wang M, Ravindranath SR, Rahim MK, Botvinick EL, Haun JB. Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions. Langmuir. 2016 12 13; 32(49):13124-13136. PMID: 27797529.
      View in: PubMed
    10. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. PMID: 27914984.
      View in: PubMed
    11. Hsieh JY, Smith TD, Meli VS, Tran TN, Botvinick EL, Liu WF. Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomater. 2017 01 01; 47:14-24. PMID: 27662809.
      View in: PubMed
    12. Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC. Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tissue Eng Part A. 2016 08; 22(15-16):1016-25. PMID: 27392582.
      View in: PubMed
    13. Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 2016 10 01; 43:122-138. PMID: 27475528.
      View in: PubMed
    14. Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL. Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Sci Rep. 2015 Oct 16; 5:15153. PMID: 26472542.
      View in: PubMed
    15. Brown AC, Baker SR, Douglas AM, Keating M, Alvarez-Elizondo MB, Botvinick EL, Guthold M, Barker TH. Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties. Biomaterials. 2015 May; 49:27-36. PMID: 25725552.
      View in: PubMed
    16. Kim TJ, Joo C, Seong J, Vafabakhsh R, Botvinick EL, Berns MW, Palmer AE, Wang N, Ha T, Jakobsson E, Sun J, Wang Y. Distinct mechanisms regulating mechanical force-induced Ca²? signals at the plasma membrane and the ER in human MSCs. Elife. 2015 Feb 10; 4:e04876. PMID: 25667984.
      View in: PubMed
    17. Compton JL, Luo JC, Ma H, Botvinick E, Venugopalan V. High-throughput optical screening of cellular mechanotransduction. Nat Photonics. 2014 Sep 01; 8:710-715. PMID: 25309621.
      View in: PubMed
    18. Weidling J, Sameni S, Lakey JR, Botvinick E. Method measuring oxygen tension and transport within subcutaneous devices. J Biomed Opt. 2014 Aug; 19(8):087006. PMID: 25162910.
      View in: PubMed
    19. Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28; 25(4):402-16. PMID: 23685250; PMCID: PMC3736823.
    20. Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC. Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury. Am J Respir Cell Mol Biol. 2013 Mar; 48(3):299-305. PMID: 23221044.
      View in: PubMed
    21. Weidling J, Isikman SO, Greenbaum A, Ozcan A, Botvinick E. Lens-free computational imaging of capillary morphogenesis within three-dimensional substrates. J Biomed Opt. 2012 Dec; 17(12):126018. PMID: 23235893.
      View in: PubMed
    22. Alavi SH, Ruiz V, Krasieva T, Botvinick EL, Kheradvar A. Characterizing the collagen fiber orientation in pericardial leaflets under mechanical loading conditions. Ann Biomed Eng. 2013 Mar; 41(3):547-61. PMID: 23180029.
      View in: PubMed
    23. Shergill B, Meloty-Kapella L, Musse AA, Weinmaster G, Botvinick E. Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis. Dev Cell. 2012 Jun 12; 22(6):1313-20. PMID: 22658935; PMCID: PMC3376165.
    24. Meloty-Kapella L, Shergill B, Kuon J, Botvinick E, Weinmaster G. Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Dev Cell. 2012 Jun 12; 22(6):1299-312. PMID: 22658936; PMCID: PMC3400432.
    25. Kniazeva E, Weidling JW, Singh R, Botvinick EL, Digman MA, Gratton E, Putnam AJ. Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D. Integr Biol (Camb). 2012 Apr; 4(4):431-9. PMID: 22281872.
      View in: PubMed
    26. Shreim SG, Steward E, Botvinick EL. Extending vaterite microviscometry to ex vivo blood vessels by serial calibration. Biomed Opt Express. 2012 Jan 01; 3(1):37-47. PMID: 22254166.
      View in: PubMed
    27. Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J Appl Physiol (1985). 2012 Feb; 112(4):627-37. PMID: 22114176.
      View in: PubMed
    28. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Adv Mater. 2011 Dec 22; 23(48):5785-91. PMID: 22065428.
      View in: PubMed
    29. Anderson SM, Shergill B, Barry ZT, Manousiouthakis E, Chen TT, Botvinick E, Platt MO, Iruela-Arispe ML, Segura T. VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. Integr Biol (Camb). 2011 Sep; 3(9):887-96. PMID: 21826315; PMCID: PMC3621282.
    30. Dyer D, Shreim S, Jayadev S, Lew V, Botvinick E, Khine M. Sequential shrink photolithography for plastic microlens arrays. Appl Phys Lett. 2011 Jul 18; 99(3):34102-341023. PMID: 21863126.
      View in: PubMed
    31. Kotlarchyk MA, Shreim SG, Alvarez-Elizondo MB, Estrada LC, Singh R, Valdevit L, Kniazeva E, Gratton E, Putnam AJ, Botvinick EL. Concentration independent modulation of local micromechanics in a fibrin gel. PLoS One. 2011; 6(5):e20201. PMID: 21629793.
      View in: PubMed
    32. Shi LZ, Nascimento J, Botvinick E, Durrant B, Berns MW. An interdisciplinary systems approach to study sperm physiology and evolution. Wiley Interdiscip Rev Syst Biol Med. 2011 Jan-Feb; 3(1):36-47. PMID: 21064038.
      View in: PubMed
    33. Wakida NM, Botvinick EL, Lin J, Berns MW. An intact centrosome is required for the maintenance of polarization during directional cell migration. PLoS One. 2010 Dec 23; 5(12):e15462. PMID: 21203421.
      View in: PubMed
    34. Kotlarchyk MA, Botvinick EL, Putnam AJ. Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging. J Phys Condens Matter. 2010 May 19; 22(19):194121. PMID: 20877437.
      View in: PubMed
    35. Hur SS, Zhao Y, Li YS, Botvinick E, Chien S. Live Cells Exert 3-Dimensional Traction Forces on Their Substrata. Cell Mol Bioeng. 2009 Sep; 2(3):425-436. PMID: 19779633.
      View in: PubMed
    36. Nascimento JM, Shi LZ, Tam J, Chandsawangbhuwana C, Durrant B, Botvinick EL, Berns MW. Comparison of glycolysis and oxidative phosphorylation as energy sources for mammalian sperm motility, using the combination of fluorescence imaging, laser tweezers, and real-time automated tracking and trapping. J Cell Physiol. 2008 Dec; 217(3):745-51. PMID: 18683212.
      View in: PubMed
    37. Preece D, Keen S, Botvinick E, Bowman R, Padgett M, Leach J. Independent polarisation control of multiple optical traps. Opt Express. 2008 Sep 29; 16(20):15897-902. PMID: 18825226.
      View in: PubMed
    38. Shi LZ, Nascimento JM, Chandsawangbhuwana C, Botvinick EL, Berns MW. An automatic system to study sperm motility and energetics. Biomed Microdevices. 2008 Aug; 10(4):573-83. PMID: 18299996.
      View in: PubMed
    39. Nascimento JM, Shi LZ, Meyers S, Gagneux P, Loskutoff NM, Botvinick EL, Berns MW. The use of optical tweezers to study sperm competition and motility in primates. J R Soc Interface. 2008 Mar 06; 5(20):297-302. PMID: 17650470.
      View in: PubMed
    40. Nascimento JM, Shi LZ, Chandsawangbhuwana C, Tam J, Durrant B, Botvinick EL, Berns MW. Use of laser tweezers to analyze sperm motility and mitochondrial membrane potential. J Biomed Opt. 2008 Jan-Feb; 13(1):014002. PMID: 18315360.
      View in: PubMed
    41. Shao B, Shi LZ, Nascimento JM, Botvinick EL, Ozkan M, Berns MW, Esener SC. High-throughput sorting and analysis of human sperm with a ring-shaped laser trap. Biomed Microdevices. 2007 Jun; 9(3):361-9. PMID: 17226100.
      View in: PubMed
    42. Botvinick EL, Shah JV. Laser-based measurements in cell biology. Methods Cell Biol. 2007; 82:81-109. PMID: 17586255.
      View in: PubMed
    43. Shao B, Nascimento JM, Shi LZ, Botvinick EL. Automated motile cell capture and analysis with optical traps. Methods Cell Biol. 2007; 82:601-27. PMID: 17586273.
      View in: PubMed
    44. Botvinick EL, Wang Y. Laser tweezers in the study of mechanobiology in live cells. Methods Cell Biol. 2007; 82:497-523. PMID: 17586270.
      View in: PubMed
    45. Shao B, Esener SC, Nascimento JM, Berns MW, Botvinick EL, Ozkan M. Size tunable three-dimensional annular laser trap based on axicons. Opt Lett. 2006 Nov 15; 31(22):3375-7. PMID: 17072428.
      View in: PubMed
    46. Shi LZ, Nascimento J, Chandsawangbhuwana C, Berns MW, Botvinick EL. Real-time automated tracking and trapping system for sperm. Microsc Res Tech. 2006 Nov; 69(11):894-902. PMID: 16892192.
      View in: PubMed
    47. Shao B, Esener SC, Nascimento JM, Botvinick EL, Berns MW. Dynamically adjustable annular laser trapping based on axicons. Appl Opt. 2006 Sep 01; 45(25):6421-8. PMID: 16912778.
      View in: PubMed
    48. Shi LZ, Nascimento JM, Berns MW, Botvinick EL. Computer-based tracking of single sperm. J Biomed Opt. 2006 Sep-Oct; 11(5):054009. PMID: 17092158.
      View in: PubMed
    49. Nascimento JM, Nascimento JL, Botvinick EL, Shi LZ, Durrant B, Berns MW. Analysis of sperm motility using optical tweezers. J Biomed Opt. 2006 Jul-Aug; 11(4):044001. PMID: 16965158.
      View in: PubMed
    50. Botvinick EL, Berns MW. Internet-based robotic laser scissors and tweezers microscopy. Microsc Res Tech. 2005 Oct; 68(2):65-74. PMID: 16228982.
      View in: PubMed
    51. Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, Tsien RY, Chien S. Visualizing the mechanical activation of Src. Nature. 2005 Apr 21; 434(7036):1040-5. PMID: 15846350.
      View in: PubMed
    52. Botvinick EL, Venugopalan V, Shah JV, Liaw LH, Berns MW. Controlled ablation of microtubules using a picosecond laser. Biophys J. 2004 Dec; 87(6):4203-12. PMID: 15454403.
      View in: PubMed
    53. Shah JV, Botvinick E, Bonday Z, Furnari F, Berns M, Cleveland DW. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol. 2004 Jun 08; 14(11):942-52. PMID: 15182667.
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    54. Gough DA, Botvinick EL. Reservations on the use of error grid analysis for the validation of blood glucose assays. Diabetes Care. 1997 Jun; 20(6):1034-6. PMID: 9167120.
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