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Elliot L Botvinick

Title(s)Professor, Beckman Laser Institute
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-9613
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    Collapse Research 
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    Multiphoton Microscope for Cardiovascular and Tissue Engineering
    NIH S10OD025064Aug 1, 2019 - Jul 31, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Photostable and Proteolysis-Resistant Förster Resonance Energy Transfer-Based Calcium Biosensor. Anal Chem. 2020 Jun 02; 92(11):7683-7689. Nguyen D, Behrens DM, Sen S, Najdahmadi A, Pham JN, Speciale G, Lawrence MM, Majumdar S, Weiss GA, Botvinick EL. PMID: 32352281.
      View in: PubMed   Mentions:    Fields:    
    2. The Effect of a Fast-Releasing Hydrogen Sulfide Donor on Vascularization of Subcutaneous Scaffolds in Immunocompetent and Immunocompromised Mice. Biomolecules. 2020 May 06; 10(5). Smink AM, Najdahmadi A, Alexander M, Li S, Rodriquez S, van Goor H, Hillebrands JL, Botvinick E, Lakey JRT, Vos P. PMID: 32384680.
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    3. A bench-top model of middle ear effusion diagnosed with optical tympanometry. Int J Pediatr Otorhinolaryngol. 2020 Jul; 134:110054. Shreim S, Abouzari M, Weidling J, White S, Goshtasbi K, Pham N, Djalilian HR, Botvinick E. PMID: 32344235.
      View in: PubMed   Mentions:    Fields:    
    4. Non-Invasive Monitoring of Oxygen Tension and Oxygen Transport Inside Subcutaneous Devices After H2S Treatment. Cell Transplant. 2020 Jan-Dec; 29:963689719893936. Najdahmadi A, Smink AM, de Vos P, Lakey JRT, Botvinick E. PMID: 32024377.
      View in: PubMed   Mentions:    Fields:    
    5. Bijel-templated implantable biomaterials for enhancing tissue integration and vascularization. Acta Biomater. 2019 08; 94:173-182. Thorson TJ, Gurlin RE, Botvinick EL, Mohraz A. PMID: 31233892.
      View in: PubMed   Mentions: 1     Fields:    
    6. Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation. APL Bioeng. 2019 Mar; 3(1):016103. Hsieh JY, Keating MT, Smith TD, Meli VS, Botvinick EL, Liu WF. PMID: 31069336.
      View in: PubMed   Mentions:
    7. Selective stiffening of fibrin hydrogels with micron resolution via photocrosslinking. Acta Biomater. 2019 03 15; 87:88-96. Keating M, Lim M, Hu Q, Botvinick E. PMID: 30660778.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State. Cancer Res. 2018 05 15; 78(10):2503-2512. Hou J, Williams J, Botvinick EL, Potma EO, Tromberg BJ. PMID: 29535219.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Sprouting angiogenesis induces significant mechanical heterogeneities and ECM stiffening across length scales in fibrin hydrogels. Biomaterials. 2018 04; 162:99-108. Juliar BA, Keating MT, Kong YP, Botvinick EL, Putnam AJ. PMID: 29438884.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Composite bijel-templated hydrogels for cell delivery. ACS Biomater Sci Eng. 2018 Feb 12; 4(2):587-594. Thorson TJ, Botvinick EL, Mohraz A. PMID: 30555892.
      View in: PubMed   Mentions:
    11. Spatial distributions of pericellular stiffness in natural extracellular matrices are dependent on cell-mediated proteolysis and contractility. Acta Biomater. 2017 07 15; 57:304-312. Keating M, Kurup A, Alvarez-Elizondo M, Levine AJ, Botvinick E. PMID: 28483696.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. Vascularization and innervation of slits within polydimethylsiloxane sheets in the subcutaneous space of athymic nude mice. J Tissue Eng. 2017 Jan-Dec; 8:2041731417691645. Gurlin RE, Keating MT, Li S, Lakey JR, de Feraudy S, Shergill BS, Botvinick EL. PMID: 28228933.
      View in: PubMed   Mentions:
    13. Evolution of Multivalent Nanoparticle Adhesion via Specific Molecular Interactions. Langmuir. 2016 12 13; 32(49):13124-13136. Wang M, Ravindranath SR, Rahim MK, Botvinick EL, Haun JB. PMID: 27797529.
      View in: PubMed   Mentions:    Fields:    
    14. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. PMID: 27914984.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Differential regulation of macrophage inflammatory activation by fibrin and fibrinogen. Acta Biomater. 2017 01 01; 47:14-24. Hsieh JY, Smith TD, Meli VS, Tran TN, Botvinick EL, Liu WF. PMID: 27662809.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tissue Eng Part A. 2016 08; 22(15-16):1016-25. Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC. PMID: 27392582.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    17. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 2016 10 01; 43:122-138. Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA. PMID: 27475528.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    18. Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Sci Rep. 2015 Oct 16; 5:15153. Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL. PMID: 26472542.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties. Biomaterials. 2015 May; 49:27-36. Brown AC, Baker SR, Douglas AM, Keating M, Alvarez-Elizondo MB, Botvinick EL, Guthold M, Barker TH. PMID: 25725552.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Distinct mechanisms regulating mechanical force-induced Ca²? signals at the plasma membrane and the ER in human MSCs. Elife. 2015 Feb 10; 4:e04876. Kim TJ, Joo C, Seong J, Vafabakhsh R, Botvinick EL, Berns MW, Palmer AE, Wang N, Ha T, Jakobsson E, Sun J, Wang Y. PMID: 25667984.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    21. High-throughput optical screening of cellular mechanotransduction. Nat Photonics. 2014 Sep 01; 8:710-715. Compton JL, Luo JC, Ma H, Botvinick E, Venugopalan V. PMID: 25309621.
      View in: PubMed   Mentions:
    22. Method measuring oxygen tension and transport within subcutaneous devices. J Biomed Opt. 2014 Aug; 19(8):087006. Weidling J, Sameni S, Lakey JR, Botvinick E. PMID: 25162910.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. MT1-MMP-dependent control of skeletal stem cell commitment via a ß1-integrin/YAP/TAZ signaling axis. Dev Cell. 2013 May 28; 25(4):402-16. Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. PMID: 23685250.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    24. Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury. Am J Respir Cell Mol Biol. 2013 Mar; 48(3):299-305. Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC. PMID: 23221044.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    25. Lens-free computational imaging of capillary morphogenesis within three-dimensional substrates. J Biomed Opt. 2012 Dec; 17(12):126018. Weidling J, Isikman SO, Greenbaum A, Ozcan A, Botvinick E. PMID: 23235893.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. Characterizing the collagen fiber orientation in pericardial leaflets under mechanical loading conditions. Ann Biomed Eng. 2013 Mar; 41(3):547-61. Alavi SH, Ruiz V, Krasieva T, Botvinick EL, Kheradvar A. PMID: 23180029.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    27. Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis. Dev Cell. 2012 Jun 12; 22(6):1313-20. Shergill B, Meloty-Kapella L, Musse AA, Weinmaster G, Botvinick E. PMID: 22658935.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    28. Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Dev Cell. 2012 Jun 12; 22(6):1299-312. Meloty-Kapella L, Shergill B, Kuon J, Botvinick E, Weinmaster G. PMID: 22658936.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    29. Quantification of local matrix deformations and mechanical properties during capillary morphogenesis in 3D. Integr Biol (Camb). 2012 Apr; 4(4):431-9. Kniazeva E, Weidling JW, Singh R, Botvinick EL, Digman MA, Gratton E, Putnam AJ. PMID: 22281872.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    30. Extending vaterite microviscometry to ex vivo blood vessels by serial calibration. Biomed Opt Express. 2012 Jan 01; 3(1):37-47. Shreim SG, Steward E, Botvinick EL. PMID: 22254166.
      View in: PubMed   Mentions:
    31. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction. J Appl Physiol (1985). 2012 Feb; 112(4):627-37. Zhou J, Alvarez-Elizondo MB, Botvinick E, George SC. PMID: 22114176.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    32. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Adv Mater. 2011 Dec 22; 23(48):5785-91. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. PMID: 22065428.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. Integr Biol (Camb). 2011 Sep; 3(9):887-96. Anderson SM, Shergill B, Barry ZT, Manousiouthakis E, Chen TT, Botvinick E, Platt MO, Iruela-Arispe ML, Segura T. PMID: 21826315.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    34. Sequential shrink photolithography for plastic microlens arrays. Appl Phys Lett. 2011 Jul 18; 99(3):34102-341023. Dyer D, Shreim S, Jayadev S, Lew V, Botvinick E, Khine M. PMID: 21863126.
      View in: PubMed   Mentions:
    35. Concentration independent modulation of local micromechanics in a fibrin gel. PLoS One. 2011; 6(5):e20201. Kotlarchyk MA, Shreim SG, Alvarez-Elizondo MB, Estrada LC, Singh R, Valdevit L, Kniazeva E, Gratton E, Putnam AJ, Botvinick EL. PMID: 21629793.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    36. An interdisciplinary systems approach to study sperm physiology and evolution. Wiley Interdiscip Rev Syst Biol Med. 2011 Jan-Feb; 3(1):36-47. Shi LZ, Nascimento J, Botvinick E, Durrant B, Berns MW. PMID: 21064038.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    37. An intact centrosome is required for the maintenance of polarization during directional cell migration. PLoS One. 2010 Dec 23; 5(12):e15462. Wakida NM, Botvinick EL, Lin J, Berns MW. PMID: 21203421.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    38. Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging. J Phys Condens Matter. 2010 May 19; 22(19):194121. Kotlarchyk MA, Botvinick EL, Putnam AJ. PMID: 20877437.
      View in: PubMed   Mentions: 9     Fields:    
    39. Live Cells Exert 3-Dimensional Traction Forces on Their Substrata. Cell Mol Bioeng. 2009 Sep; 2(3):425-436. Hur SS, Zhao Y, Li YS, Botvinick E, Chien S. PMID: 19779633.
      View in: PubMed   Mentions:
    40. Comparison of glycolysis and oxidative phosphorylation as energy sources for mammalian sperm motility, using the combination of fluorescence imaging, laser tweezers, and real-time automated tracking and trapping. J Cell Physiol. 2008 Dec; 217(3):745-51. Nascimento JM, Shi LZ, Tam J, Chandsawangbhuwana C, Durrant B, Botvinick EL, Berns MW. PMID: 18683212.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    41. Independent polarisation control of multiple optical traps. Opt Express. 2008 Sep 29; 16(20):15897-902. Preece D, Keen S, Botvinick E, Bowman R, Padgett M, Leach J. PMID: 18825226.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    42. An automatic system to study sperm motility and energetics. Biomed Microdevices. 2008 Aug; 10(4):573-83. Shi LZ, Nascimento JM, Chandsawangbhuwana C, Botvinick EL, Berns MW. PMID: 18299996.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    43. The use of optical tweezers to study sperm competition and motility in primates. J R Soc Interface. 2008 Mar 06; 5(20):297-302. Nascimento JM, Shi LZ, Meyers S, Gagneux P, Loskutoff NM, Botvinick EL, Berns MW. PMID: 17650470.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    44. Use of laser tweezers to analyze sperm motility and mitochondrial membrane potential. J Biomed Opt. 2008 Jan-Feb; 13(1):014002. Nascimento JM, Shi LZ, Chandsawangbhuwana C, Tam J, Durrant B, Botvinick EL, Berns MW. PMID: 18315360.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    45. High-throughput sorting and analysis of human sperm with a ring-shaped laser trap. Biomed Microdevices. 2007 Jun; 9(3):361-9. Shao B, Shi LZ, Nascimento JM, Botvinick EL, Ozkan M, Berns MW, Esener SC. PMID: 17226100.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    46. Laser-based measurements in cell biology. Methods Cell Biol. 2007; 82:81-109. Botvinick EL, Shah JV. PMID: 17586255.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    47. Laser tweezers in the study of mechanobiology in live cells. Methods Cell Biol. 2007; 82:497-523. Botvinick EL, Wang Y. PMID: 17586270.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    48. Automated motile cell capture and analysis with optical traps. Methods Cell Biol. 2007; 82:601-27. Shao B, Nascimento JM, Shi LZ, Botvinick EL. PMID: 17586273.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    49. Size tunable three-dimensional annular laser trap based on axicons. Opt Lett. 2006 Nov 15; 31(22):3375-7. Shao B, Esener SC, Nascimento JM, Berns MW, Botvinick EL, Ozkan M. PMID: 17072428.
      View in: PubMed   Mentions: 2     Fields:    
    50. Real-time automated tracking and trapping system for sperm. Microsc Res Tech. 2006 Nov; 69(11):894-902. Shi LZ, Nascimento J, Chandsawangbhuwana C, Berns MW, Botvinick EL. PMID: 16892192.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    51. Dynamically adjustable annular laser trapping based on axicons. Appl Opt. 2006 Sep 01; 45(25):6421-8. Shao B, Esener SC, Nascimento JM, Botvinick EL, Berns MW. PMID: 16912778.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    52. Computer-based tracking of single sperm. J Biomed Opt. 2006 Sep-Oct; 11(5):054009. Shi LZ, Nascimento JM, Berns MW, Botvinick EL. PMID: 17092158.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    53. Analysis of sperm motility using optical tweezers. J Biomed Opt. 2006 Jul-Aug; 11(4):044001. Nascimento JM, Nascimento JL, Botvinick EL, Shi LZ, Durrant B, Berns MW. PMID: 16965158.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    54. Internet-based robotic laser scissors and tweezers microscopy. Microsc Res Tech. 2005 Oct; 68(2):65-74. Botvinick EL, Berns MW. PMID: 16228982.
      View in: PubMed   Mentions: 21     Fields:    
    55. Visualizing the mechanical activation of Src. Nature. 2005 Apr 21; 434(7036):1040-5. Wang Y, Botvinick EL, Zhao Y, Berns MW, Usami S, Tsien RY, Chien S. PMID: 15846350.
      View in: PubMed   Mentions: 245     Fields:    Translation:HumansAnimalsCells
    56. Controlled ablation of microtubules using a picosecond laser. Biophys J. 2004 Dec; 87(6):4203-12. Botvinick EL, Venugopalan V, Shah JV, Liaw LH, Berns MW. PMID: 15454403.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    57. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol. 2004 Jun 08; 14(11):942-52. Shah JV, Botvinick E, Bonday Z, Furnari F, Berns M, Cleveland DW. PMID: 15182667.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    58. Reservations on the use of error grid analysis for the validation of blood glucose assays. Diabetes Care. 1997 Jun; 20(6):1034-6. Gough DA, Botvinick EL. PMID: 9167120.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
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