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Gregory J. Brewer

Title(s)Adjunct Professor, Biomedical Engineering
Phone(949) 824-3762
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    Collapse Research 
    Collapse Research Activities and Funding
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH/NIA R01AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Mitoenergetic Failure in Brain Aging
    NIH/NIA R01AG032431Mar 1, 2009 - Feb 28, 2015
    Role: Principal Investigator
    Age-related Response of Hippocampal Neurons to Stress
    NIH/NIA R56AG013435Apr 1, 1997 - Jun 30, 2011
    Role: Principal Investigator
    Age-Dependent Response of Hippocampal Neurons to Stress
    NIH/NIA R01AG013435Apr 1, 1997 - Aug 31, 2008
    Role: Principal Investigator
    ELECTRON MICROSCOPE WITH X-RAY ANALYSIS
    NIH/NCRR S10RR004805Mar 30, 1989 - Mar 29, 1990
    Role: Principal Investigator
    LENS GAP JUNCTION RECONSTITUTION
    NIH/NEI R01EY006077Aug 1, 1986 - Jul 31, 1990
    Role: Principal Investigator
    GENETIC CONTROL OF MEMBRANE MORPHOGENESIS
    NIH/NIGMS R01GM031773Sep 1, 1985 - Aug 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Brewer GJ, Herrera RA, Philipp S, Sosna J, Reyes-Ruiz JM, Glabe CG. Age-Related Intraneuronal Aggregation of Amyloid-ß in Endosomes, Mitochondria, Autophagosomes, and Lysosomes. J Alzheimers Dis. 2019 Nov 18. PMID: 31771065.
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    2. Dong Y, Sameni S, Digman MA, Brewer GJ. Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts. Sci Rep. 2019 Aug 02; 9(1):11274. PMID: 31375701.
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    3. Dong Y, Digman MA, Brewer GJ. Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy. Geroscience. 2019 02; 41(1):51-67. PMID: 30729413.
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    4. Dong Y, Brewer GJ. Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites. J Alzheimers Dis. 2019; 71(1):119-140. PMID: 31356210.
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    5. Poli D, Wheeler BC, DeMarse TB, Brewer GJ. Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks. J Neural Eng. 2018 08; 15(4):046009. PMID: 29623900.
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    6. Poli D, DeMarse TB, Wheeler BC, Brewer GJ. Specific CA3 neurons decode neural information of dentate granule cells evoked by paired-pulse stimulation in co-cultured networks. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3628-3631. PMID: 29060684.
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    7. Narula U, Ruiz A, McQuaide M, DeMarse TB, Wheeler BC, Brewer GJ. Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks. PLoS One. 2017; 12(5):e0176868. PMID: 28493886.
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    8. Poli D, Thiagarajan S, DeMarse TB, Wheeler BC, Brewer GJ. Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks. Front Neural Circuits. 2017; 11:13. PMID: 28321182.
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    9. Bhattacharya A, Desai H, DeMarse TB, Wheeler BC, Brewer GJ. Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits. 2016; 10:45. PMID: 27445701.
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    10. DeMarse TB, Pan L, Alagapan S, Brewer GJ, Wheeler BC. Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits. 2016; 10:32. PMID: 27147977.
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    11. LeVault KR, Tischkau SA, Brewer GJ. Circadian Disruption Reveals a Correlation of an Oxidative GSH/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2016; 49(2):301-16. PMID: 26484899.
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    12. Pan L, Alagapan S, Franca E, Leondopulos SS, DeMarse TB, Brewer GJ, Wheeler BC. An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits. 2015; 9:32. PMID: 26236198.
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    13. Ghosh D, Levault KR, Brewer GJ. Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell. 2014 Aug; 13(4):631-40. PMID: 24655393.
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    14. Ghosh D, Brewer GJ. External cys/cySS redox state modification controls the intracellular redox state and neurodegeneration via Akt in aging and Alzheimer's disease mouse model neurons. J Alzheimers Dis. 2014; 42(1):313-24. PMID: 24844688.
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    15. Pan L, Alagapan S, Franca E, DeMarse T, Brewer GJ, Wheeler BC. Large extracellular spikes recordable from axons in microtunnels. IEEE Trans Neural Syst Rehabil Eng. 2014 May; 22(3):453-9. PMID: 24240004.
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    16. Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, DeMarse TB, Wheeler BC. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits. 2013; 7:165. PMID: 24155693.
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    17. Ghosh D, LeVault KR, Brewer GJ. Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species. Neurobiol Aging. 2014 Jan; 35(1):179-90. PMID: 23954169.
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    18. Ghosh D, LeVault KR, Barnett AJ, Brewer GJ. A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J Neurosci. 2012 Apr 25; 32(17):5821-32. PMID: 22539844.
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    19. Leondopulos SS, Boehler MD, Wheeler BC, Brewer GJ. Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng. 2012 Apr; 9(2):026015. PMID: 22361724.
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    20. Walker MP, LaFerla FM, Oddo SS, Brewer GJ. Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr). 2013 Jun; 35(3):519-31. PMID: 22237558.
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    21. Boehler MD, Leondopulos SS, Wheeler BC, Brewer GJ. Hippocampal networks on reliable patterned substrates. J Neurosci Methods. 2012 Jan 30; 203(2):344-53. PMID: 21985763.
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    22. Pan L, Alagapan S, Franca E, Brewer GJ, Wheeler BC. Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng. 2011 Aug; 8(4):046031. PMID: 21750372.
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    23. Barnett A, Brewer GJ. Autophagy in aging and Alzheimer's disease: pathologic or protective? J Alzheimers Dis. 2011; 25(3):385-94. PMID: 21422527.
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    24. Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells. J Agric Food Chem. 2010 Jul 28; 58(14):8196-204. PMID: 20597478.
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    25. Wheeler BC, Brewer GJ. Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes. Proc IEEE Inst Electr Electron Eng. 2010 Mar 01; 98(3):398-406. PMID: 21625406.
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    26. Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D. Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Cancer Biol Ther. 2010 Jan; 9(2):122-33. PMID: 19923925.
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    27. Ide AN, Andruska A, Boehler M, Wheeler BC, Brewer GJ. Chronic network stimulation enhances evoked action potentials. J Neural Eng. 2010 Feb; 7(1):16008. PMID: 20083862.
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    28. Brewer GJ. Why vitamin E therapy fails for treatment of Alzheimer's disease. J Alzheimers Dis. 2010; 19(1):27-30. PMID: 20061623.
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    29. Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX. Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J Alzheimers Dis. 2010; 22(2):393-9. PMID: 20847431.
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    30. Parihar MS, Brewer GJ. Amyloid-ß as a modulator of synaptic plasticity. J Alzheimers Dis. 2010; 22(3):741-63. PMID: 20847424.
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    31. Brewer GJ, Torricelli JR, Lindsey AL, Kunz EZ, Neuman A, Fisher DR, Joseph JA. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem. 2010 Oct; 21(10):991-8. PMID: 19954954.
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    32. Brewer GJ. Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp Gerontol. 2010 Mar; 45(3):173-9. PMID: 19945522.
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    33. Jones TT, Brewer GJ. Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport. Biochim Biophys Acta. 2010 Feb; 1797(2):167-76. PMID: 19799853.
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    34. Brewer GJ, Boehler MD, Ide AN, Wheeler BC. Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates. J Neurosci Methods. 2009 Oct 30; 184(1):104-9. PMID: 19666055.
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    35. Vernekar VN, Cullen DK, Fogleman N, Choi Y, García AJ, Allen MG, Brewer GJ, LaPlaca MC. SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications. J Biomed Mater Res A. 2009 Apr; 89(1):138-51. PMID: 18431778.
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    36. Brewer GJ, Boehler MD, Pearson RA, DeMaris AA, Ide AN, Wheeler BC. Neuron network activity scales exponentially with synapse density. J Neural Eng. 2009 Feb; 6(1):014001. PMID: 19104141.
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    37. Jones TT, Brewer GJ. Critical age-related loss of cofactors of neuron cytochrome C oxidase reversed by estrogen. Exp Neurol. 2009 Feb; 215(2):212-9. PMID: 18930048.
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    38. Parihar MS, Kunz EA, Brewer GJ. Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons. J Neurosci Res. 2008 Aug 01; 86(10):2339-52. PMID: 18438923.
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    39. Patel JR, Brewer GJ. Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid. J Neurosci Res. 2008 Aug 01; 86(10):2303-13. PMID: 18418902.
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    40. Patel JR, Brewer GJ. Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons. Exp Neurol. 2008 Sep; 213(1):93-100. PMID: 18625500.
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    41. Brewer GJ, Boehler MD, Jones TT, Wheeler BC. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008 May 30; 170(2):181-7. PMID: 18308400.
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    42. Jajoo S, Mukherjea D, Brewer GJ, Ramkumar V. Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. Neuroscience. 2008 Jan 24; 151(2):525-32. PMID: 18093742.
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    43. Joseph JA, Carey A, Brewer GJ, Lau FC, Fisher DR. Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J Alzheimers Dis. 2007 Jul; 11(4):433-46. PMID: 17656822.
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    44. Boehler MD, Wheeler BC, Brewer GJ. Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol. 2007 May; 3(2):127-40. PMID: 18345351.
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    45. Brewer GJ, LeRoux PD. Human primary brain tumor cell growth inhibition in serum-free medium optimized for neuron survival. Brain Res. 2007 Jul 09; 1157:156-66. PMID: 17537410.
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    46. Parihar MS, Brewer GJ. Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons. J Neurosci Res. 2007 Apr; 85(5):1018-32. PMID: 17335078.
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    47. Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB. Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks. Lab Chip. 2007 Apr; 7(4):475-82. PMID: 17389964.
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    48. Nam Y, Brewer GJ, Wheeler BC. Development of astroglial cells in patterned neuronal cultures. J Biomater Sci Polym Ed. 2007; 18(8):1091-100. PMID: 17706000.
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    49. Brewer GJ, Torricelli JR. Isolation and culture of adult neurons and neurospheres. Nat Protoc. 2007; 2(6):1490-8. PMID: 17545985.
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    50. Chang JC, Brewer GJ, Wheeler BC. Neuronal network structuring induces greater neuronal activity through enhanced astroglial development. J Neural Eng. 2006 Sep; 3(3):217-26. PMID: 16921205.
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    51. Parihar MS, Brewer GJ. Mitoenergetic failure in Alzheimer disease. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C8-23. PMID: 16807300.
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    52. Vogt AK, Brewer GJ, Offenhäusser A. Connectivity patterns in neuronal networks of experimentally defined geometry. Tissue Eng. 2005 Nov-Dec; 11(11-12):1757-67. PMID: 16411821.
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    53. Brewer GJ, Reichensperger JD, Brinton RD. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiol Aging. 2006 Feb; 27(2):306-17. PMID: 15961189.
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    54. Brewer GJ, Lim A, Capps NG, Torricelli JR. Age-related calcium changes, oxyradical damage, caspase activation and nuclear condensation in hippocampal neurons in response to glutamate and beta-amyloid. Exp Gerontol. 2005 May; 40(5):426-37. PMID: 15919595.
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    55. Vogt AK, Brewer GJ, Decker T, Böcker-Meffert S, Jacobsen V, Kreiter M, Knoll W, Offenhäusser A. Independence of synaptic specificity from neuritic guidance. Neuroscience. 2005; 134(3):783-90. PMID: 16009499.
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    56. Brewer GJ, Jones TT, Wallimann T, Schlattner U. Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants. Mitochondrion. 2004 Jun; 4(1):49-57. PMID: 16120374.
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    57. Nam Y, Chang J, Khatami D, Brewer GJ, Wheeler BC. Patterning to enhance activity of cultured neuronal networks. IEE Proc Nanobiotechnol. 2004 Jun; 151(3):109-15. PMID: 16475852.
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    58. Viel JJ, McManus DQ, Brewer GJ. Postmortem effect of pentobarbital anesthetic on survival of adult cortical neurons in primary culture. Brain Res. 2004 May 29; 1009(1-2):219-22. PMID: 15120600.
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    59. Khatami D, Nam Y, Brewer G, Wheeler B. Effect of bicuculline on the spontaneous and evoked activity of patterned embryonic hippocampal neurons cultured in vitro. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4059-62. PMID: 17271191.
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    60. Wheeler BC, Nam Y, Brewer GJ. Patterning to influence in vitro neuronal interfaces. Conf Proc IEEE Eng Med Biol Soc. 2004; 7:5337-9. PMID: 17271547.
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    61. Nam Y, Chang JC, Wheeler BC, Brewer GJ. Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal cultures. IEEE Trans Biomed Eng. 2004 Jan; 51(1):158-65. PMID: 14723505.
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    62. Chang JC, Brewer GJ, Wheeler BC. A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. Biomaterials. 2003 Aug; 24(17):2863-70. PMID: 12742724.
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    63. Brewer GJ, Espinosa JA, Struble RG. Effect of Neuregen nutrient medium on survival of cortical neurons after aspiration lesion in rats. J Neurosurg. 2003 Jun; 98(6):1291-8. PMID: 12816277.
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    64. Patel JR, Brewer GJ. Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid. J Neurosci Res. 2003 May 15; 72(4):527-36. PMID: 12704814.
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    65. Nathan BP, Jiang Y, Wong GK, Shen F, Brewer GJ, Struble RG. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 2002 Feb 22; 928(1-2):96-105. PMID: 11844476.
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    66. Cady C, Evans MS, Brewer GJ. Age-related differences in NMDA responses in cultured rat hippocampal neurons. Brain Res. 2001 Dec 07; 921(1-2):1-11. PMID: 11720706.
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    67. Chang JC, Brewer GJ, Wheeler BC. Modulation of neural network activity by patterning. Biosens Bioelectron. 2001 Sep; 16(7-8):527-33. PMID: 11544046.
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    68. Viel JJ, McManus DQ, Smith SS, Brewer GJ. Age- and concentration-dependent neuroprotection and toxicity by TNF in cortical neurons from beta-amyloid. J Neurosci Res. 2001 Jun 01; 64(5):454-65. PMID: 11391700.
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    69. Brewer GJ, Espinosa J, McIlhaney MP, Pencek TP, Kesslak JP, Cotman C, Viel J, McManus DC. Culture and regeneration of human neurons after brain surgery. J Neurosci Methods. 2001 May 30; 107(1-2):15-23. PMID: 11389937.
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    70. Viel JJ, McManus DQ, Cady C, Evans MS, Brewer GJ. Temperature and time interval for culture of postmortem neurons from adult rat cortex. J Neurosci Res. 2001 May 15; 64(4):311-21. PMID: 11340637.
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    71. Branch DW, Wheeler BC, Brewer GJ, Leckband DE. Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture. Biomaterials. 2001 May; 22(10):1035-47. PMID: 11352085.
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    72. Brewer GJ. Neuronal plasticity and stressor toxicity during aging. Exp Gerontol. 2000 Dec; 35(9-10):1165-83. PMID: 11113600.
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    73. Zhu X, Rottkamp CA, Raina AK, Brewer GJ, Ghanbari HA, Boux H, Smith MA. Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Neurobiol Aging. 2000 Nov-Dec; 21(6):807-13. PMID: 11124424.
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    74. Hallam DM, Capps NL, Travelstead AL, Brewer GJ, Maroun LE. Evidence for an interferon-related inflammatory reaction in the trisomy 16 mouse brain leading to caspase-1-mediated neuronal apoptosis. J Neuroimmunol. 2000 Oct 02; 110(1-2):66-75. PMID: 11024535.
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    75. Brewer GJ, Wallimann TW. Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. J Neurochem. 2000 May; 74(5):1968-78. PMID: 10800940.
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    76. Branch DW, Wheeler BC, Brewer GJ, Leckband DE. Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine. IEEE Trans Biomed Eng. 2000 Mar; 47(3):290-300. PMID: 10743770.
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    77. Liu J, Evans MS, Brewer GJ, Lee TJ. N-type Ca2+ channels in cultured rat sphenopalatine ganglion neurons: an immunohistochemical and electrophysiological study. J Cereb Blood Flow Metab. 2000 Jan; 20(1):183-91. PMID: 10616807.
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    78. Yang Y, Quitschke WW, Vostrov AA, Brewer GJ. CTCF is essential for up-regulating expression from the amyloid precursor protein promoter during differentiation of primary hippocampal neurons. J Neurochem. 1999 Dec; 73(6):2286-98. PMID: 10582586.
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    79. Brewer GJ. Regeneration and proliferation of embryonic and adult rat hippocampal neurons in culture. Exp Neurol. 1999 Sep; 159(1):237-47. PMID: 10486191.
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    80. Wheeler BC, Corey JM, Brewer GJ, Branch DW. Microcontact printing for precise control of nerve cell growth in culture. J Biomech Eng. 1999 Feb; 121(1):73-8. PMID: 10080092.
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    81. Collings MA, Brewer GJ, Evans MS. Calcium currents of embryonic and adult neurons in serum-free culture. Brain Res Bull. 1999 Jan 01; 48(1):73-8. PMID: 10210170.
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    82. Brewer GJ, Deshmane S, Ponnusamy E. Precocious axons and improved survival of rat hippocampal neurons on lysine-alanine polymer substrates. J Neurosci Methods. 1998 Nov 01; 85(1):13-20. PMID: 9874136.
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    83. Brewer GJ. Age-related toxicity to lactate, glutamate, and beta-amyloid in cultured adult neurons. Neurobiol Aging. 1998 Nov-Dec; 19(6):561-8. PMID: 10192215.
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    84. Yang Y, Quitschke WW, Brewer GJ. Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. Brain Res Mol Brain Res. 1998 Sep 18; 60(1):40-9. PMID: 9748493.
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    85. Evans MS, Collings MA, Brewer GJ. Electrophysiology of embryonic, adult and aged rat hippocampal neurons in serum-free culture. J Neurosci Methods. 1998 Jan 31; 79(1):37-46. PMID: 9531458.
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    86. Branch DW, Corey JM, Weyhenmeyer JA, Brewer GJ, Wheeler BC. Microstamp patterns of biomolecules for high-resolution neuronal networks. Med Biol Eng Comput. 1998 Jan; 36(1):135-41. PMID: 9614762.
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    87. Corey JM, Brunette AL, Chen MS, Weyhenmeyer JA, Brewer GJ, Wheeler BC. Differentiated B104 neuroblastoma cells are a high-resolution assay for micropatterned substrates. J Neurosci Methods. 1997 Jul 18; 75(1):91-7. PMID: 9262149.
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    88. Yang Y, Akiyama H, Fenton JW, Brewer GJ. Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses. Brain Res. 1997 Jun 27; 761(1):11-8. PMID: 9247061.
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    89. Brewer GJ. Effects of acidosis on the distribution of processing of the beta-amyloid precursor protein in cultured hippocampal neurons. Mol Chem Neuropathol. 1997 Jun; 31(2):171-86. PMID: 9376023.
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    90. Watabe M, Gross S, Lawyer C, Brewer GJ, Mashimo T, Watabe K. Sequence and functional analysis of the 5'-flanking region of the mouse growth inhibitory factor gene. Cell Mol Neurobiol. 1997 Apr; 17(2):235-43. PMID: 9140700.
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    91. McManus DQ, Brewer GJ. Culture of neurons from postmortem rat brain. Neurosci Lett. 1997 Mar 21; 224(3):193-6. PMID: 9131669.
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    92. Brewer GJ. Isolation and culture of adult rat hippocampal neurons. J Neurosci Methods. 1997 Feb; 71(2):143-55. PMID: 9128149.
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    93. Loeffler DA, LeWitt PA, Juneau PL, Sima AA, Nguyen HU, DeMaggio AJ, Brickman CM, Brewer GJ, Dick RD, Troyer MD, Kanaley L. Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders. Brain Res. 1996 Nov 04; 738(2):265-74. PMID: 8955522.
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    94. Corey JM, Wheeler BC, Brewer GJ. Micrometer resolution silane-based patterning of hippocampal neurons: critical variables in photoresist and laser ablation processes for substrate fabrication. IEEE Trans Biomed Eng. 1996 Sep; 43(9):944-55. PMID: 9214810.
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    95. Brewer GJ. Thrombin causes cell spreading and redistribution of beta-amyloid immunoreactivity in cultured hippocampal neurons. J Neurochem. 1996 Jul; 67(1):119-30. PMID: 8666982.
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    96. Brewer GJ, Price PJ. Viable cultured neurons in ambient carbon dioxide and hibernation storage for a month. Neuroreport. 1996 Jun 17; 7(9):1509-12. PMID: 8856709.
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    97. Brewer GJ. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res. 1995 Dec; 42(5):674-83. PMID: 8600300.
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    98. Brewer GJ. Exogenous thrombin inhibits neuritogenesis in cultured neuroblastoma cells but not in rat hippocampal neurons. Brain Res. 1995 Jun 19; 683(2):258-63. PMID: 7552363.
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    99. Brewer GJ, Torricelli JR, Evege EK, Price PJ. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res. 1993 Aug 01; 35(5):567-76. PMID: 8377226.
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    100. Brewer GJ, Ashford JW. Human serum stimulates Alzheimer markers in cultured hippocampal neurons. J Neurosci Res. 1992 Nov; 33(3):355-69. PMID: 1335088.
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    101. Brewer GJ, Matinyan N. Congregation of gangliosides at the junction between two model membranes. Biochemistry. 1992 Feb 18; 31(6):1816-20. PMID: 1737034.
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    102. Brewer GJ. Polarity decrease at the adhesive junction between two model membranes containing gangliosides. Biochemistry. 1992 Feb 18; 31(6):1809-15. PMID: 1737033.
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    103. Corey JM, Wheeler BC, Brewer GJ. Compliance of hippocampal neurons to patterned substrate networks. J Neurosci Res. 1991 Oct; 30(2):300-7. PMID: 1798054.
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    104. Thomas PD, Brewer GJ. Gangliosides and synaptic transmission. Biochim Biophys Acta. 1990 Oct 08; 1031(3):277-89. PMID: 2171656.
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    105. Armour GA, Brewer GJ. Membrane morphogenesis from cloned fragments of bacteriophage PM2 DNA that contain the sp6.6 gene. FASEB J. 1990 Mar; 4(5):1488-93. PMID: 2407591.
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    106. Brewer GJ, Cotman CW. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res. 1989 Aug 07; 494(1):65-74. PMID: 2765923.
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