Loading...

Gregory J. Brewer

TitleAdjunct Professor
InstitutionUniversity of California, Irvine
DepartmentBiomedical Engineering
Address3101 Natural Sciences II
Zot 2715
Irvine CA 92697
Phone(949) 824-3762
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH/NIA R01AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Mitoenergetic Failure in Brain Aging
    NIH/NIA R01AG032431Mar 1, 2009 - Feb 28, 2015
    Role: Principal Investigator
    Age-related Response of Hippocampal Neurons to Stress
    NIH/NIA R56AG013435Apr 1, 1997 - Jun 30, 2011
    Role: Principal Investigator
    Age-Dependent Response of Hippocampal Neurons to Stress
    NIH/NIA R01AG013435Apr 1, 1997 - Aug 31, 2008
    Role: Principal Investigator
    ELECTRON MICROSCOPE WITH X-RAY ANALYSIS
    NIH/NCRR S10RR004805Mar 30, 1989 - Mar 29, 1990
    Role: Principal Investigator
    LENS GAP JUNCTION RECONSTITUTION
    NIH/NEI R01EY006077Aug 1, 1986 - Jul 31, 1990
    Role: Principal Investigator
    GENETIC CONTROL OF MEMBRANE MORPHOGENESIS
    NIH/NIGMS R01GM031773Sep 1, 1985 - Aug 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Poli D, Wheeler BC, DeMarse TB, Brewer GJ. Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks. J Neural Eng. 2018 Apr 06; 15(4):046009. PMID: 29623900.
      View in: PubMed
    2. Poli D, DeMarse TB, Wheeler BC, Brewer GJ. Specific CA3 neurons decode neural information of dentate granule cells evoked by paired-pulse stimulation in co-cultured networks. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3628-3631. PMID: 29060684.
      View in: PubMed
    3. Narula U, Ruiz A, McQuaide M, DeMarse TB, Wheeler BC, Brewer GJ. Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks. PLoS One. 2017; 12(5):e0176868. PMID: 28493886.
      View in: PubMed
    4. Poli D, Thiagarajan S, DeMarse TB, Wheeler BC, Brewer GJ. Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks. Front Neural Circuits. 2017; 11:13. PMID: 28321182.
      View in: PubMed
    5. Bhattacharya A, Desai H, DeMarse TB, Wheeler BC, Brewer GJ. Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits. 2016; 10:45. PMID: 27445701; PMCID: PMC4923256.
    6. DeMarse TB, Pan L, Alagapan S, Brewer GJ, Wheeler BC. Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits. 2016; 10:32. PMID: 27147977; PMCID: PMC4840215.
    7. Pan L, Alagapan S, Franca E, Leondopulos SS, DeMarse TB, Brewer GJ, Wheeler BC. An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits. 2015; 9:32. PMID: 26236198; PMCID: PMC4500931.
    8. Pan L, Alagapan S, Franca E, DeMarse T, Brewer GJ, Wheeler BC. Large extracellular spikes recordable from axons in microtunnels. IEEE Trans Neural Syst Rehabil Eng. 2014 May; 22(3):453-9. PMID: 24240004; PMCID: PMC4013201.
    9. Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, DeMarse TB, Wheeler BC. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits. 2013; 7:165. PMID: 24155693; PMCID: PMC3800815.
    10. Leondopulos SS, Boehler MD, Wheeler BC, Brewer GJ. Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng. 2012 Apr; 9(2):026015. PMID: 22361724; PMCID: PMC3376752.
    11. Boehler MD, Leondopulos SS, Wheeler BC, Brewer GJ. Hippocampal networks on reliable patterned substrates. J Neurosci Methods. 2012 Jan 30; 203(2):344-53. PMID: 21985763; PMCID: PMC3246106.
    12. Pan L, Alagapan S, Franca E, Brewer GJ, Wheeler BC. Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng. 2011 Aug; 8(4):046031. PMID: 21750372; PMCID: PMC3213028.
    13. Wheeler BC, Brewer GJ. Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes. Proc IEEE Inst Electr Electron Eng. 2010 Mar 01; 98(3):398-406. PMID: 21625406.
      View in: PubMed
    14. Brewer GJ, Boehler MD, Ide AN, Wheeler BC. Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates. J Neurosci Methods. 2009 Oct 30; 184(1):104-9. PMID: 19666055; PMCID: PMC2753692.
    15. Vernekar VN, Cullen DK, Fogleman N, Choi Y, GarcĂ­a AJ, Allen MG, Brewer GJ, LaPlaca MC. SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications. J Biomed Mater Res A. 2009 Apr; 89(1):138-51. PMID: 18431778.
      View in: PubMed
    16. Brewer GJ, Boehler MD, Jones TT, Wheeler BC. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008 May 30; 170(2):181-7. PMID: 18308400; PMCID: PMC2393548.
    17. Boehler MD, Wheeler BC, Brewer GJ. Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol. 2007 May; 3(2):127-40. PMID: 18345351; PMCID: PMC2267743.
    18. Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB. Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks. Lab Chip. 2007 Apr; 7(4):475-82. PMID: 17389964.
      View in: PubMed
    19. Nam Y, Brewer GJ, Wheeler BC. Development of astroglial cells in patterned neuronal cultures. J Biomater Sci Polym Ed. 2007; 18(8):1091-100. PMID: 17706000.
      View in: PubMed
    20. Chang JC, Brewer GJ, Wheeler BC. Neuronal network structuring induces greater neuronal activity through enhanced astroglial development. J Neural Eng. 2006 Sep; 3(3):217-26. PMID: 16921205.
      View in: PubMed
    21. Khatami D, Nam Y, Brewer G, Wheeler B. Effect of bicuculline on the spontaneous and evoked activity of patterned embryonic hippocampal neurons cultured in vitro. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4059-62. PMID: 17271191.
      View in: PubMed
    22. Wheeler BC, Nam Y, Brewer GJ. Patterning to influence in vitro neuronal interfaces. Conf Proc IEEE Eng Med Biol Soc. 2004; 7:5337-9. PMID: 17271547.
      View in: PubMed
    23. Nam Y, Chang JC, Wheeler BC, Brewer GJ. Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal cultures. IEEE Trans Biomed Eng. 2004 Jan; 51(1):158-65. PMID: 14723505.
      View in: PubMed
    24. Chang JC, Brewer GJ, Wheeler BC. A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. Biomaterials. 2003 Aug; 24(17):2863-70. PMID: 12742724.
      View in: PubMed
    Gregory's Networks
    Concepts
    Derived automatically from this person's publications.
    _
    Co-Authors
    People in Profiles who have published with this person.
    _
    Related Authors
    People who share related concepts with this person.
    _