Gregory J. Brewer

Title(s)Adjunct Professor, Biomedical Engineering
SchoolSamueli School of Engineering
Address3101 Natural Sciences II
Zot 2715
Irvine CA 92697
Phone(949) 824-3762
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    Collapse Research 
    Collapse Research Activities and Funding
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH/NIA R01AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH RF1AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Mitoenergetic Failure in Brain Aging
    NIH R01AG032431Mar 1, 2009 - Dec 31, 2015
    Role: Principal Investigator
    Age-related Response of Hippocampal Neurons to Stress
    NIH R56AG013435Apr 1, 1997 - Jun 30, 2011
    Role: Principal Investigator
    Age-Dependent Response of Hippocampal Neurons to Stress
    NIH R01AG013435Apr 1, 1997 - Aug 31, 2008
    Role: Principal Investigator
    ELECTRON MICROSCOPE WITH X-RAY ANALYSIS
    NIH S10RR004805Mar 30, 1989 - Mar 29, 1990
    Role: Principal Investigator
    LENS GAP JUNCTION RECONSTITUTION
    NIH R01EY006077Aug 1, 1986 - Jul 31, 1990
    Role: Principal Investigator
    GENETIC CONTROL OF MEMBRANE MORPHOGENESIS
    NIH R01GM031773Sep 1, 1985 - Aug 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Spindle oscillations in communicating axons within a reconstituted hippocampal formation are strongest in CA3 without thalamus. Sci Rep. 2024 04 10; 14(1):8384. Wang M, Lassers SB, Vakilna YS, Mander BA, Tang WC, Brewer GJ. PMID: 38600114; PMCID: PMC11006914.
      View in: PubMed   Mentions:
    2. The flow of axonal information among hippocampal sub-regions 2: patterned stimulation sharpens routing of information transmission. Front Neural Circuits. 2023; 17:1272925. Lassers SB, Vakilna YS, Tang WC, Brewer GJ. PMID: 38144878; PMCID: PMC10739322.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Hippocampal network axons respond to patterned theta burst stimulation with lower activity of initially higher spike train similarity from EC to DG and later similarity of axons from CA1 to EC. J Neural Eng. 2023 09 12; 20(5). Chen R, Vakilna YS, Lassers SB, Tang WC, Brewer G. PMID: 37666242.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. GTP energy dependence of endocytosis and autophagy in the aging brain and Alzheimer's disease. Geroscience. 2023 04; 45(2):757-780. Martínez RAS, Pinky PD, Harlan BA, Brewer GJ. PMID: 36622562; PMCID: PMC9886713.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2022; 90(4):1501-1521. Pontrello CG, McWhirt JM, Glabe CG, Brewer GJ. PMID: 36278355; PMCID: PMC9789488.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. The Flow of Axonal Information Among Hippocampal Subregions: 1. Feed-Forward and Feedback Network Spatial Dynamics Underpinning Emergent Information Processing. Front Neural Circuits. 2021; 15:660837. Vakilna YS, Tang WC, Wheeler BC, Brewer GJ. PMID: 34512275; PMCID: PMC8430040.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. When aging switches on Alzheimer's. Aging (Albany NY). 2021 05 20; 13(10):13376-13377. Dong Y, Harlan BA, Brewer GJ. PMID: 34019488; PMCID: PMC8202892.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes. J Alzheimers Dis. 2020; 73(1):229-246. Brewer GJ, Herrera RA, Philipp S, Sosna J, Reyes-Ruiz JM, Glabe CG. PMID: 31771065; PMCID: PMC7029321.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    9. Reversibility of Age-related Oxidized Free NADH Redox States in Alzheimer's Disease Neurons by Imposed External Cys/CySS Redox Shifts. Sci Rep. 2019 08 02; 9(1):11274. Dong Y, Sameni S, Digman MA, Brewer GJ. PMID: 31375701; PMCID: PMC6677822.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy. Geroscience. 2019 02; 41(1):51-67. Dong Y, Digman MA, Brewer GJ. PMID: 30729413; PMCID: PMC6423217.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    11. Global Metabolic Shifts in Age and Alzheimer's Disease Mouse Brains Pivot at NAD+/NADH Redox Sites. J Alzheimers Dis. 2019; 71(1):119-140. Dong Y, Brewer GJ. PMID: 31356210; PMCID: PMC6839468.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    12. Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks. J Neural Eng. 2018 08; 15(4):046009. Poli D, Wheeler BC, DeMarse TB, Brewer GJ. PMID: 29623900; PMCID: PMC6021217.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    13. Specific CA3 neurons decode neural information of dentate granule cells evoked by paired-pulse stimulation in co-cultured networks. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:3628-3631. Poli D, DeMarse TB, Wheeler BC, Brewer GJ. PMID: 29060684.
      View in: PubMed   Mentions: 1     Fields:    
    14. Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks. PLoS One. 2017; 12(5):e0176868. Narula U, Ruiz A, McQuaide M, DeMarse TB, Wheeler BC, Brewer GJ. PMID: 28493886; PMCID: PMC5426613.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks. Front Neural Circuits. 2017; 11:13. Poli D, Thiagarajan S, DeMarse TB, Wheeler BC, Brewer GJ. PMID: 28321182; PMCID: PMC5337490.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits. 2016; 10:45. Bhattacharya A, Desai H, DeMarse TB, Wheeler BC, Brewer GJ. PMID: 27445701; PMCID: PMC4923256.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits. 2016; 10:32. DeMarse TB, Pan L, Alagapan S, Brewer GJ, Wheeler BC. PMID: 27147977; PMCID: PMC4840215.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    18. Circadian Disruption Reveals a Correlation of an Oxidative GSH/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2016; 49(2):301-16. LeVault KR, Tischkau SA, Brewer GJ. PMID: 26484899.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits. 2015; 9:32. Pan L, Alagapan S, Franca E, Leondopulos SS, DeMarse TB, Brewer GJ, Wheeler BC. PMID: 26236198; PMCID: PMC4500931.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    20. Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell. 2014 Aug; 13(4):631-40. Ghosh D, Levault KR, Brewer GJ. PMID: 24655393; PMCID: PMC4116450.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    21. External cys/cySS redox state modification controls the intracellular redox state and neurodegeneration via Akt in aging and Alzheimer's disease mouse model neurons. J Alzheimers Dis. 2014; 42(1):313-24. Ghosh D, Brewer GJ. PMID: 24844688; PMCID: PMC6099062.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Large extracellular spikes recordable from axons in microtunnels. IEEE Trans Neural Syst Rehabil Eng. 2014 May; 22(3):453-9. Pan L, Alagapan S, Franca E, DeMarse T, Brewer GJ, Wheeler BC. PMID: 24240004; PMCID: PMC4013201.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    23. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits. 2013; 7:165. Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, DeMarse TB, Wheeler BC. PMID: 24155693; PMCID: PMC3800815.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    24. Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species. Neurobiol Aging. 2014 Jan; 35(1):179-90. Ghosh D, LeVault KR, Brewer GJ. PMID: 23954169; PMCID: PMC6099064.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    25. A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J Neurosci. 2012 Apr 25; 32(17):5821-32. Ghosh D, LeVault KR, Barnett AJ, Brewer GJ. PMID: 22539844; PMCID: PMC3376759.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    26. Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng. 2012 Apr; 9(2):026015. Leondopulos SS, Boehler MD, Wheeler BC, Brewer GJ. PMID: 22361724; PMCID: PMC3376752.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr). 2013 Jun; 35(3):519-31. Walker MP, LaFerla FM, Oddo SS, Brewer GJ. PMID: 22237558; PMCID: PMC3636384.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    28. Hippocampal networks on reliable patterned substrates. J Neurosci Methods. 2012 Jan 30; 203(2):344-53. Boehler MD, Leondopulos SS, Wheeler BC, Brewer GJ. PMID: 21985763; PMCID: PMC3246106.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    29. Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng. 2011 Aug; 8(4):046031. Pan L, Alagapan S, Franca E, Brewer GJ, Wheeler BC. PMID: 21750372; PMCID: PMC3213028.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    30. Autophagy in aging and Alzheimer's disease: pathologic or protective? J Alzheimers Dis. 2011; 25(3):385-94. Barnett A, Brewer GJ. PMID: 21422527; PMCID: PMC3547650.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    31. Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells. J Agric Food Chem. 2010 Jul 28; 58(14):8196-204. Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. PMID: 20597478; PMCID: PMC3079309.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    32. Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes. Proc IEEE Inst Electr Electron Eng. 2010 Mar 01; 98(3):398-406. Wheeler BC, Brewer GJ. PMID: 21625406; PMCID: PMC3101502.
      View in: PubMed   Mentions: 42  
    33. Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Cancer Biol Ther. 2010 Jan; 9(2):122-33. Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D. PMID: 19923925; PMCID: PMC2909490.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    34. Chronic network stimulation enhances evoked action potentials. J Neural Eng. 2010 Feb; 7(1):16008. Ide AN, Andruska A, Boehler M, Wheeler BC, Brewer GJ. PMID: 20083862; PMCID: PMC3775841.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    35. Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J Alzheimers Dis. 2010; 22(2):393-9. Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX. PMID: 20847431; PMCID: PMC3079347.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimals
    36. Amyloid-β as a modulator of synaptic plasticity. J Alzheimers Dis. 2010; 22(3):741-63. Parihar MS, Brewer GJ. PMID: 20847424; PMCID: PMC3079354.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    37. Why vitamin E therapy fails for treatment of Alzheimer's disease. J Alzheimers Dis. 2010; 19(1):27-30. Brewer GJ. PMID: 20061623; PMCID: PMC3023173.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    38. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem. 2010 Oct; 21(10):991-8. Brewer GJ, Torricelli JR, Lindsey AL, Kunz EZ, Neuman A, Fisher DR, Joseph JA. PMID: 19954954; PMCID: PMC2891857.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    39. Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp Gerontol. 2010 Mar; 45(3):173-9. Brewer GJ. PMID: 19945522; PMCID: PMC2826600.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    40. Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport. Biochim Biophys Acta. 2010 Feb; 1797(2):167-76. Jones TT, Brewer GJ. PMID: 19799853; PMCID: PMC2812684.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    41. Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates. J Neurosci Methods. 2009 Oct 30; 184(1):104-9. Brewer GJ, Boehler MD, Ide AN, Wheeler BC. PMID: 19666055; PMCID: PMC2753692.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    42. SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications. J Biomed Mater Res A. 2009 Apr; 89(1):138-51. Vernekar VN, Cullen DK, Fogleman N, Choi Y, García AJ, Allen MG, Brewer GJ, LaPlaca MC. PMID: 18431778.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    43. Neuron network activity scales exponentially with synapse density. J Neural Eng. 2009 Feb; 6(1):014001. Brewer GJ, Boehler MD, Pearson RA, DeMaris AA, Ide AN, Wheeler BC. PMID: 19104141; PMCID: PMC2679226.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    44. Critical age-related loss of cofactors of neuron cytochrome C oxidase reversed by estrogen. Exp Neurol. 2009 Feb; 215(2):212-9. Jones TT, Brewer GJ. PMID: 18930048; PMCID: PMC3018880.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    45. Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons. J Neurosci Res. 2008 Aug 01; 86(10):2339-52. Parihar MS, Kunz EA, Brewer GJ. PMID: 18438923.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    46. Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid. J Neurosci Res. 2008 Aug 01; 86(10):2303-13. Patel JR, Brewer GJ. PMID: 18418902; PMCID: PMC2562897.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    47. Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons. Exp Neurol. 2008 Sep; 213(1):93-100. Patel JR, Brewer GJ. PMID: 18625500; PMCID: PMC2597588.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    48. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008 May 30; 170(2):181-7. Brewer GJ, Boehler MD, Jones TT, Wheeler BC. PMID: 18308400; PMCID: PMC2393548.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    49. Pertussis toxin B-oligomer suppresses human immunodeficiency virus-1 Tat-induced neuronal apoptosis through feedback inhibition of phospholipase C-beta by protein kinase C. Neuroscience. 2008 Jan 24; 151(2):525-32. Jajoo S, Mukherjea D, Brewer GJ, Ramkumar V. PMID: 18093742.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    50. Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J Alzheimers Dis. 2007 Jul; 11(4):433-46. Joseph JA, Carey A, Brewer GJ, Lau FC, Fisher DR. PMID: 17656822.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    51. Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol. 2007 May; 3(2):127-40. Boehler MD, Wheeler BC, Brewer GJ. PMID: 18345351; PMCID: PMC2267743.
      View in: PubMed   Mentions: 29     Fields:    
    52. Human primary brain tumor cell growth inhibition in serum-free medium optimized for neuron survival. Brain Res. 2007 Jul 09; 1157:156-66. Brewer GJ, LeRoux PD. PMID: 17537410.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    53. Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons. J Neurosci Res. 2007 Apr; 85(5):1018-32. Parihar MS, Brewer GJ. PMID: 17335078.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    54. Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks. Lab Chip. 2007 Apr; 7(4):475-82. Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB. PMID: 17389964.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    55. Development of astroglial cells in patterned neuronal cultures. J Biomater Sci Polym Ed. 2007; 18(8):1091-100. Nam Y, Brewer GJ, Wheeler BC. PMID: 17706000.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    56. Isolation and culture of adult neurons and neurospheres. Nat Protoc. 2007; 2(6):1490-8. Brewer GJ, Torricelli JR. PMID: 17545985.
      View in: PubMed   Mentions: 221     Fields:    Translation:AnimalsCells
    57. Neuronal network structuring induces greater neuronal activity through enhanced astroglial development. J Neural Eng. 2006 Sep; 3(3):217-26. Chang JC, Brewer GJ, Wheeler BC. PMID: 16921205.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    58. Mitoenergetic failure in Alzheimer disease. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C8-23. Parihar MS, Brewer GJ. PMID: 16807300.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    59. Connectivity patterns in neuronal networks of experimentally defined geometry. Tissue Eng. 2005 Nov-Dec; 11(11-12):1757-67. Vogt AK, Brewer GJ, Offenhäusser A. PMID: 16411821.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    60. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiol Aging. 2006 Feb; 27(2):306-17. Brewer GJ, Reichensperger JD, Brinton RD. PMID: 15961189.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    61. Age-related calcium changes, oxyradical damage, caspase activation and nuclear condensation in hippocampal neurons in response to glutamate and beta-amyloid. Exp Gerontol. 2005 May; 40(5):426-37. Brewer GJ, Lim A, Capps NG, Torricelli JR. PMID: 15919595.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    62. Independence of synaptic specificity from neuritic guidance. Neuroscience. 2005; 134(3):783-90. Vogt AK, Brewer GJ, Decker T, Böcker-Meffert S, Jacobsen V, Kreiter M, Knoll W, Offenhäusser A. PMID: 16009499.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    63. Higher respiratory rates and improved creatine stimulation in brain mitochondria isolated with anti-oxidants. Mitochondrion. 2004 Jun; 4(1):49-57. Brewer GJ, Jones TT, Wallimann T, Schlattner U. PMID: 16120374.
      View in: PubMed   Mentions: 5     Fields:    
    64. Patterning to enhance activity of cultured neuronal networks. IEE Proc Nanobiotechnol. 2004 Jun; 151(3):109-15. Nam Y, Chang J, Khatami D, Brewer GJ, Wheeler BC. PMID: 16475852.
      View in: PubMed   Mentions: 17     Fields:    
    65. Postmortem effect of pentobarbital anesthetic on survival of adult cortical neurons in primary culture. Brain Res. 2004 May 29; 1009(1-2):219-22. Viel JJ, McManus DQ, Brewer GJ. PMID: 15120600.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    66. Patterning to influence in vitro neuronal interfaces. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:5337-9. Wheeler BC, Nam Y, Brewer GJ. PMID: 17271547.
      View in: PubMed   Mentions: 1     Fields:    
    67. Effect of bicuculline on the spontaneous and evoked activity of patterned embryonic hippocampal neurons cultured in vitro. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:4059-62. Khatami D, Nam Y, Brewer G, Wheeler B. PMID: 17271191.
      View in: PubMed   Mentions: 1     Fields:    
    68. Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal cultures. IEEE Trans Biomed Eng. 2004 Jan; 51(1):158-65. Nam Y, Chang JC, Wheeler BC, Brewer GJ. PMID: 14723505.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    69. A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. Biomaterials. 2003 Aug; 24(17):2863-70. Chang JC, Brewer GJ, Wheeler BC. PMID: 12742724.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    70. Effect of Neuregen nutrient medium on survival of cortical neurons after aspiration lesion in rats. J Neurosurg. 2003 Jun; 98(6):1291-8. Brewer GJ, Espinosa JA, Struble RG. PMID: 12816277.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    71. Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid. J Neurosci Res. 2003 May 15; 72(4):527-36. Patel JR, Brewer GJ. PMID: 12704814.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    72. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 2002 Feb 22; 928(1-2):96-105. Nathan BP, Jiang Y, Wong GK, Shen F, Brewer GJ, Struble RG. PMID: 11844476.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    73. Age-related differences in NMDA responses in cultured rat hippocampal neurons. Brain Res. 2001 Dec 07; 921(1-2):1-11. Cady C, Evans MS, Brewer GJ. PMID: 11720706.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    74. Modulation of neural network activity by patterning. Biosens Bioelectron. 2001 Sep; 16(7-8):527-33. Chang JC, Brewer GJ, Wheeler BC. PMID: 11544046.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    75. Temperature and time interval for culture of postmortem neurons from adult rat cortex. J Neurosci Res. 2001 May 15; 64(4):311-21. Viel JJ, McManus DQ, Cady C, Evans MS, Brewer GJ. PMID: 11340637.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    76. Long-term stability of grafted polyethylene glycol surfaces for use with microstamped substrates in neuronal cell culture. Biomaterials. 2001 May; 22(10):1035-47. Branch DW, Wheeler BC, Brewer GJ, Leckband DE. PMID: 11352085.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    77. Neuronal plasticity and stressor toxicity during aging. Exp Gerontol. 2000 Dec; 35(9-10):1165-83. Brewer GJ. PMID: 11113600.
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    78. Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Neurobiol Aging. 2000 Nov-Dec; 21(6):807-13. Zhu X, Rottkamp CA, Raina AK, Brewer GJ, Ghanbari HA, Boux H, Smith MA. PMID: 11124424.
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    79. Evidence for an interferon-related inflammatory reaction in the trisomy 16 mouse brain leading to caspase-1-mediated neuronal apoptosis. J Neuroimmunol. 2000 Oct 02; 110(1-2):66-75. Hallam DM, Capps NL, Travelstead AL, Brewer GJ, Maroun LE. PMID: 11024535.
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    80. Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. J Neurochem. 2000 May; 74(5):1968-78. Brewer GJ, Wallimann TW. PMID: 10800940.
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    81. Long-term maintenance of patterns of hippocampal pyramidal cells on substrates of polyethylene glycol and microstamped polylysine. IEEE Trans Biomed Eng. 2000 Mar; 47(3):290-300. Branch DW, Wheeler BC, Brewer GJ, Leckband DE. PMID: 10743770.
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    82. N-type Ca2+ channels in cultured rat sphenopalatine ganglion neurons: an immunohistochemical and electrophysiological study. J Cereb Blood Flow Metab. 2000 Jan; 20(1):183-91. Liu J, Evans MS, Brewer GJ, Lee TJ. PMID: 10616807.
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    83. CTCF is essential for up-regulating expression from the amyloid precursor protein promoter during differentiation of primary hippocampal neurons. J Neurochem. 1999 Dec; 73(6):2286-98. Yang Y, Quitschke WW, Vostrov AA, Brewer GJ. PMID: 10582586.
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    84. Regeneration and proliferation of embryonic and adult rat hippocampal neurons in culture. Exp Neurol. 1999 Sep; 159(1):237-47. Brewer GJ. PMID: 10486191.
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    85. Microcontact printing for precise control of nerve cell growth in culture. J Biomech Eng. 1999 Feb; 121(1):73-8. Wheeler BC, Corey JM, Brewer GJ, Branch DW. PMID: 10080092.
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    86. Calcium currents of embryonic and adult neurons in serum-free culture. Brain Res Bull. 1999 Jan 01; 48(1):73-8. Collings MA, Brewer GJ, Evans MS. PMID: 10210170.
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    87. Age-related toxicity to lactate, glutamate, and beta-amyloid in cultured adult neurons. Neurobiol Aging. 1998 Nov-Dec; 19(6):561-8. Brewer GJ. PMID: 10192215.
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    88. Precocious axons and improved survival of rat hippocampal neurons on lysine-alanine polymer substrates. J Neurosci Methods. 1998 Nov 01; 85(1):13-20. Brewer GJ, Deshmane S, Ponnusamy E. PMID: 9874136.
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    89. Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. Brain Res Mol Brain Res. 1998 Sep 18; 60(1):40-9. Yang Y, Quitschke WW, Brewer GJ. PMID: 9748493.
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    90. Electrophysiology of embryonic, adult and aged rat hippocampal neurons in serum-free culture. J Neurosci Methods. 1998 Jan 31; 79(1):37-46. Evans MS, Collings MA, Brewer GJ. PMID: 9531458.
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    91. Microstamp patterns of biomolecules for high-resolution neuronal networks. Med Biol Eng Comput. 1998 Jan; 36(1):135-41. Branch DW, Corey JM, Weyhenmeyer JA, Brewer GJ, Wheeler BC. PMID: 9614762.
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    92. Differentiated B104 neuroblastoma cells are a high-resolution assay for micropatterned substrates. J Neurosci Methods. 1997 Jul 18; 75(1):91-7. Corey JM, Brunette AL, Chen MS, Weyhenmeyer JA, Brewer GJ, Wheeler BC. PMID: 9262149.
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    93. Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses. Brain Res. 1997 Jun 27; 761(1):11-8. Yang Y, Akiyama H, Fenton JW, Brewer GJ. PMID: 9247061.
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    94. Effects of acidosis on the distribution of processing of the beta-amyloid precursor protein in cultured hippocampal neurons. Mol Chem Neuropathol. 1997 Jun; 31(2):171-86. Brewer GJ. PMID: 9376023.
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    95. Sequence and functional analysis of the 5'-flanking region of the mouse growth inhibitory factor gene. Cell Mol Neurobiol. 1997 Apr; 17(2):235-43. Watabe M, Gross S, Lawyer C, Brewer GJ, Mashimo T, Watabe K. PMID: 9140700.
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    96. Culture of neurons from postmortem rat brain. Neurosci Lett. 1997 Mar 21; 224(3):193-6. McManus DQ, Brewer GJ. PMID: 9131669.
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    97. Isolation and culture of adult rat hippocampal neurons. J Neurosci Methods. 1997 Feb; 71(2):143-55. Brewer GJ. PMID: 9128149.
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    98. Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders. Brain Res. 1996 Nov 04; 738(2):265-74. Loeffler DA, LeWitt PA, Juneau PL, Sima AA, Nguyen HU, DeMaggio AJ, Brickman CM, Brewer GJ, Dick RD, Troyer MD, Kanaley L. PMID: 8955522.
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    99. Micrometer resolution silane-based patterning of hippocampal neurons: critical variables in photoresist and laser ablation processes for substrate fabrication. IEEE Trans Biomed Eng. 1996 Sep; 43(9):944-55. Corey JM, Wheeler BC, Brewer GJ. PMID: 9214810.
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    100. Thrombin causes cell spreading and redistribution of beta-amyloid immunoreactivity in cultured hippocampal neurons. J Neurochem. 1996 Jul; 67(1):119-30. Brewer GJ. PMID: 8666982.
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    101. Viable cultured neurons in ambient carbon dioxide and hibernation storage for a month. Neuroreport. 1996 Jun 17; 7(9):1509-12. Brewer GJ, Price PJ. PMID: 8856709.
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    102. Serum-free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus. J Neurosci Res. 1995 Dec; 42(5):674-83. Brewer GJ. PMID: 8600300.
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    103. Exogenous thrombin inhibits neuritogenesis in cultured neuroblastoma cells but not in rat hippocampal neurons. Brain Res. 1995 Jun 19; 683(2):258-63. Brewer GJ. PMID: 7552363.
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    104. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res. 1993 Aug 01; 35(5):567-76. Brewer GJ, Torricelli JR, Evege EK, Price PJ. PMID: 8377226.
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    105. Human serum stimulates Alzheimer markers in cultured hippocampal neurons. J Neurosci Res. 1992 Nov; 33(3):355-69. Brewer GJ, Ashford JW. PMID: 1335088.
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    106. Polarity decrease at the adhesive junction between two model membranes containing gangliosides. Biochemistry. 1992 Feb 18; 31(6):1809-15. Brewer GJ. PMID: 1737033.
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    107. Congregation of gangliosides at the junction between two model membranes. Biochemistry. 1992 Feb 18; 31(6):1816-20. Brewer GJ, Matinyan N. PMID: 1737034.
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    108. Compliance of hippocampal neurons to patterned substrate networks. J Neurosci Res. 1991 Oct; 30(2):300-7. Corey JM, Wheeler BC, Brewer GJ. PMID: 1798054.
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    109. Gangliosides and synaptic transmission. Biochim Biophys Acta. 1990 Oct 08; 1031(3):277-89. Thomas PD, Brewer GJ. PMID: 2171656.
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    110. Membrane morphogenesis from cloned fragments of bacteriophage PM2 DNA that contain the sp6.6 gene. FASEB J. 1990 Mar; 4(5):1488-93. Armour GA, Brewer GJ. PMID: 2407591.
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    111. Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen. Brain Res. 1989 Aug 07; 494(1):65-74. Brewer GJ, Cotman CW. PMID: 2765923.
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    112. NMDA receptor regulation of neuronal morphology in cultured hippocampal neurons. Neurosci Lett. 1989 May 08; 99(3):268-73. Brewer GJ, Cotman CW. PMID: 2566963.
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