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Gregory J. Brewer

Title(s)Adjunct Professor, Biomedical Engineering
Phone(949) 824-3762
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    Collapse Research Activities and Funding
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH/NIA R01AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Mitoenergetic Failure in Brain Aging
    NIH/NIA R01AG032431Mar 1, 2009 - Feb 28, 2015
    Role: Principal Investigator
    Age-related Response of Hippocampal Neurons to Stress
    NIH/NIA R56AG013435Apr 1, 1997 - Jun 30, 2011
    Role: Principal Investigator
    Age-Dependent Response of Hippocampal Neurons to Stress
    NIH/NIA R01AG013435Apr 1, 1997 - Aug 31, 2008
    Role: Principal Investigator
    ELECTRON MICROSCOPE WITH X-RAY ANALYSIS
    NIH/NCRR S10RR004805Mar 30, 1989 - Mar 29, 1990
    Role: Principal Investigator
    LENS GAP JUNCTION RECONSTITUTION
    NIH/NEI R01EY006077Aug 1, 1986 - Jul 31, 1990
    Role: Principal Investigator
    GENETIC CONTROL OF MEMBRANE MORPHOGENESIS
    NIH/NIGMS R01GM031773Sep 1, 1985 - Aug 31, 1989
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Dong Y, Digman MA, Brewer GJ. Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy. Geroscience. 2019 Feb 06. PMID: 30729413.
      View in: PubMed
    2. Poli D, Wheeler BC, DeMarse TB, Brewer GJ. Pattern separation and completion of distinct axonal inputs transmitted via micro-tunnels between co-cultured hippocampal dentate, CA3, CA1 and entorhinal cortex networks. J Neural Eng. 2018 Aug; 15(4):046009. PMID: 29623900.
      View in: PubMed
    3. Poli D, DeMarse TB, Wheeler BC, Brewer GJ. Specific CA3 neurons decode neural information of dentate granule cells evoked by paired-pulse stimulation in co-cultured networks. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:3628-3631. PMID: 29060684.
      View in: PubMed
    4. Narula U, Ruiz A, McQuaide M, DeMarse TB, Wheeler BC, Brewer GJ. Narrow microtunnel technology for the isolation and precise identification of axonal communication among distinct hippocampal subregion networks. PLoS One. 2017; 12(5):e0176868. PMID: 28493886.
      View in: PubMed
    5. Poli D, Thiagarajan S, DeMarse TB, Wheeler BC, Brewer GJ. Sparse and Specific Coding during Information Transmission between Co-cultured Dentate Gyrus and CA3 Hippocampal Networks. Front Neural Circuits. 2017; 11:13. PMID: 28321182.
      View in: PubMed
    6. Bhattacharya A, Desai H, DeMarse TB, Wheeler BC, Brewer GJ. Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks. Front Neural Circuits. 2016; 10:45. PMID: 27445701; PMCID: PMC4923256.
    7. DeMarse TB, Pan L, Alagapan S, Brewer GJ, Wheeler BC. Feed-Forward Propagation of Temporal and Rate Information between Cortical Populations during Coherent Activation in Engineered In Vitro Networks. Front Neural Circuits. 2016; 10:32. PMID: 27147977; PMCID: PMC4840215.
    8. LeVault KR, Tischkau SA, Brewer GJ. Circadian Disruption Reveals a Correlation of an Oxidative GSH/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2016; 49(2):301-16. PMID: 26484899.
      View in: PubMed
    9. Pan L, Alagapan S, Franca E, Leondopulos SS, DeMarse TB, Brewer GJ, Wheeler BC. An in vitro method to manipulate the direction and functional strength between neural populations. Front Neural Circuits. 2015; 9:32. PMID: 26236198; PMCID: PMC4500931.
    10. Ghosh D, Levault KR, Brewer GJ. Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons. Aging Cell. 2014 Aug; 13(4):631-40. PMID: 24655393.
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    11. Ghosh D, Brewer GJ. External cys/cySS redox state modification controls the intracellular redox state and neurodegeneration via Akt in aging and Alzheimer's disease mouse model neurons. J Alzheimers Dis. 2014; 42(1):313-24. PMID: 24844688.
      View in: PubMed
    12. Pan L, Alagapan S, Franca E, DeMarse T, Brewer GJ, Wheeler BC. Large extracellular spikes recordable from axons in microtunnels. IEEE Trans Neural Syst Rehabil Eng. 2014 May; 22(3):453-9. PMID: 24240004; PMCID: PMC4013201.
    13. Brewer GJ, Boehler MD, Leondopulos S, Pan L, Alagapan S, DeMarse TB, Wheeler BC. Toward a self-wired active reconstruction of the hippocampal trisynaptic loop: DG-CA3. Front Neural Circuits. 2013; 7:165. PMID: 24155693; PMCID: PMC3800815.
    14. Ghosh D, LeVault KR, Brewer GJ. Dual-energy precursor and nuclear erythroid-related factor 2 activator treatment additively improve redox glutathione levels and neuron survival in aging and Alzheimer mouse neurons upstream of reactive oxygen species. Neurobiol Aging. 2014 Jan; 35(1):179-90. PMID: 23954169.
      View in: PubMed
    15. Ghosh D, LeVault KR, Barnett AJ, Brewer GJ. A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J Neurosci. 2012 Apr 25; 32(17):5821-32. PMID: 22539844.
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    16. Leondopulos SS, Boehler MD, Wheeler BC, Brewer GJ. Chronic stimulation of cultured neuronal networks boosts low-frequency oscillatory activity at theta and gamma with spikes phase-locked to gamma frequencies. J Neural Eng. 2012 Apr; 9(2):026015. PMID: 22361724; PMCID: PMC3376752.
    17. Walker MP, LaFerla FM, Oddo SS, Brewer GJ. Reversible epigenetic histone modifications and Bdnf expression in neurons with aging and from a mouse model of Alzheimer's disease. Age (Dordr). 2013 Jun; 35(3):519-31. PMID: 22237558; PMCID: PMC3636384.
    18. Boehler MD, Leondopulos SS, Wheeler BC, Brewer GJ. Hippocampal networks on reliable patterned substrates. J Neurosci Methods. 2012 Jan 30; 203(2):344-53. PMID: 21985763; PMCID: PMC3246106.
    19. Pan L, Alagapan S, Franca E, Brewer GJ, Wheeler BC. Propagation of action potential activity in a predefined microtunnel neural network. J Neural Eng. 2011 Aug; 8(4):046031. PMID: 21750372; PMCID: PMC3213028.
    20. Barnett A, Brewer GJ. Autophagy in aging and Alzheimer's disease: pathologic or protective? J Alzheimers Dis. 2011; 25(3):385-94. PMID: 21422527.
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    21. Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. Differential protection among fractionated blueberry polyphenolic families against DA-, Abeta(42)- and LPS-induced decrements in Ca(2+) buffering in primary hippocampal cells. J Agric Food Chem. 2010 Jul 28; 58(14):8196-204. PMID: 20597478.
      View in: PubMed
    22. Wheeler BC, Brewer GJ. Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes. Proc IEEE Inst Electr Electron Eng. 2010 Mar 01; 98(3):398-406. PMID: 21625406.
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    23. Yang D, Wang MT, Tang Y, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D. Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Cancer Biol Ther. 2010 Jan; 9(2):122-33. PMID: 19923925; PMCID: PMC2909490.
    24. Brewer GJ. Why vitamin E therapy fails for treatment of Alzheimer's disease. J Alzheimers Dis. 2010; 19(1):27-30. PMID: 20061623.
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    25. Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX. Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J Alzheimers Dis. 2010; 22(2):393-9. PMID: 20847431.
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    26. Parihar MS, Brewer GJ. Amyloid-ß as a modulator of synaptic plasticity. J Alzheimers Dis. 2010; 22(3):741-63. PMID: 20847424.
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    27. Brewer GJ, Torricelli JR, Lindsey AL, Kunz EZ, Neuman A, Fisher DR, Joseph JA. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem. 2010 Oct; 21(10):991-8. PMID: 19954954.
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    28. Brewer GJ. Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories. Exp Gerontol. 2010 Mar; 45(3):173-9. PMID: 19945522.
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    29. Jones TT, Brewer GJ. Age-related deficiencies in complex I endogenous substrate availability and reserve capacity of complex IV in cortical neuron electron transport. Biochim Biophys Acta. 2010 Feb; 1797(2):167-76. PMID: 19799853.
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    30. Brewer GJ, Boehler MD, Ide AN, Wheeler BC. Chronic electrical stimulation of cultured hippocampal networks increases spontaneous spike rates. J Neurosci Methods. 2009 Oct 30; 184(1):104-9. PMID: 19666055; PMCID: PMC2753692.
    31. Vernekar VN, Cullen DK, Fogleman N, Choi Y, García AJ, Allen MG, Brewer GJ, LaPlaca MC. SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications. J Biomed Mater Res A. 2009 Apr; 89(1):138-51. PMID: 18431778.
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    32. Jones TT, Brewer GJ. Critical age-related loss of cofactors of neuron cytochrome C oxidase reversed by estrogen. Exp Neurol. 2009 Feb; 215(2):212-9. PMID: 18930048.
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    33. Parihar MS, Kunz EA, Brewer GJ. Age-related decreases in NAD(P)H and glutathione cause redox declines before ATP loss during glutamate treatment of hippocampal neurons. J Neurosci Res. 2008 Aug 01; 86(10):2339-52. PMID: 18438923.
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    34. Patel JR, Brewer GJ. Age-related changes to tumor necrosis factor receptors affect neuron survival in the presence of beta-amyloid. J Neurosci Res. 2008 Aug 01; 86(10):2303-13. PMID: 18418902.
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    35. Patel JR, Brewer GJ. Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons. Exp Neurol. 2008 Sep; 213(1):93-100. PMID: 18625500.
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    36. Brewer GJ, Boehler MD, Jones TT, Wheeler BC. NbActiv4 medium improvement to Neurobasal/B27 increases neuron synapse densities and network spike rates on multielectrode arrays. J Neurosci Methods. 2008 May 30; 170(2):181-7. PMID: 18308400; PMCID: PMC2393548.
    37. Boehler MD, Wheeler BC, Brewer GJ. Added astroglia promote greater synapse density and higher activity in neuronal networks. Neuron Glia Biol. 2007 May; 3(2):127-40. PMID: 18345351; PMCID: PMC2267743.
    38. Brewer GJ, LeRoux PD. Human primary brain tumor cell growth inhibition in serum-free medium optimized for neuron survival. Brain Res. 2007 Jul 09; 1157:156-66. PMID: 17537410.
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    39. Parihar MS, Brewer GJ. Simultaneous age-related depolarization of mitochondrial membrane potential and increased mitochondrial reactive oxygen species production correlate with age-related glutamate excitotoxicity in rat hippocampal neurons. J Neurosci Res. 2007 Apr; 85(5):1018-32. PMID: 17335078.
      View in: PubMed
    40. Rowe L, Almasri M, Lee K, Fogleman N, Brewer GJ, Nam Y, Wheeler BC, Vukasinovic J, Glezer A, Frazier AB. Active 3-D microscaffold system with fluid perfusion for culturing in vitro neuronal networks. Lab Chip. 2007 Apr; 7(4):475-82. PMID: 17389964.
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    41. Nam Y, Brewer GJ, Wheeler BC. Development of astroglial cells in patterned neuronal cultures. J Biomater Sci Polym Ed. 2007; 18(8):1091-100. PMID: 17706000.
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    42. Brewer GJ, Torricelli JR. Isolation and culture of adult neurons and neurospheres. Nat Protoc. 2007; 2(6):1490-8. PMID: 17545985.
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    43. Chang JC, Brewer GJ, Wheeler BC. Neuronal network structuring induces greater neuronal activity through enhanced astroglial development. J Neural Eng. 2006 Sep; 3(3):217-26. PMID: 16921205.
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    44. Parihar MS, Brewer GJ. Mitoenergetic failure in Alzheimer disease. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C8-23. PMID: 16807300.
      View in: PubMed
    45. Brewer GJ, Reichensperger JD, Brinton RD. Prevention of age-related dysregulation of calcium dynamics by estrogen in neurons. Neurobiol Aging. 2006 Feb; 27(2):306-17. PMID: 15961189.
      View in: PubMed
    46. Brewer GJ, Lim A, Capps NG, Torricelli JR. Age-related calcium changes, oxyradical damage, caspase activation and nuclear condensation in hippocampal neurons in response to glutamate and beta-amyloid. Exp Gerontol. 2005 May; 40(5):426-37. PMID: 15919595.
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    47. Viel JJ, McManus DQ, Brewer GJ. Postmortem effect of pentobarbital anesthetic on survival of adult cortical neurons in primary culture. Brain Res. 2004 May 29; 1009(1-2):219-22. PMID: 15120600.
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    48. Khatami D, Nam Y, Brewer G, Wheeler B. Effect of bicuculline on the spontaneous and evoked activity of patterned embryonic hippocampal neurons cultured in vitro. Conf Proc IEEE Eng Med Biol Soc. 2004; 6:4059-62. PMID: 17271191.
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    49. Wheeler BC, Nam Y, Brewer GJ. Patterning to influence in vitro neuronal interfaces. Conf Proc IEEE Eng Med Biol Soc. 2004; 7:5337-9. PMID: 17271547.
      View in: PubMed
    50. Nam Y, Chang JC, Wheeler BC, Brewer GJ. Gold-coated microelectrode array with thiol linked self-assembled monolayers for engineering neuronal cultures. IEEE Trans Biomed Eng. 2004 Jan; 51(1):158-65. PMID: 14723505.
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    51. Chang JC, Brewer GJ, Wheeler BC. A modified microstamping technique enhances polylysine transfer and neuronal cell patterning. Biomaterials. 2003 Aug; 24(17):2863-70. PMID: 12742724.
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    52. Brewer GJ, Espinosa JA, Struble RG. Effect of Neuregen nutrient medium on survival of cortical neurons after aspiration lesion in rats. J Neurosurg. 2003 Jun; 98(6):1291-8. PMID: 12816277.
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    53. Patel JR, Brewer GJ. Age-related changes in neuronal glucose uptake in response to glutamate and beta-amyloid. J Neurosci Res. 2003 May 15; 72(4):527-36. PMID: 12704814.
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    54. Nathan BP, Jiang Y, Wong GK, Shen F, Brewer GJ, Struble RG. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. Brain Res. 2002 Feb 22; 928(1-2):96-105. PMID: 11844476.
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