Weian Zhao

Title(s)Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-9744
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechano-Sensing CAR-T Cells for Solid Tumor Metastases
    NIH R21CA219225Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Integrated Comprehensive Droplet Digital Detection (IC 3D) system for rapid detection of bacteria andantimicrobial resistance
    NIH R01AI117061Apr 1, 2015 - Mar 31, 2021
    Role: Principal Investigator
    Mechano-sensing stem cells to study, detect and treat cancer metastases
    NIH DP2CA195763Sep 30, 2014 - Jun 30, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Risk factors for SARS-CoV-2 seropositivity in a health care worker population during the early pandemic. BMC Infect Dis. 2023 May 16; 23(1):330. Schubl SD, Figueroa C, Palma AM, de Assis RR, Jain A, Nakajima R, Jasinskas A, Brabender D, Hosseinian S, Naaseh A, Hernandez Dominguez O, Runge A, Skochko S, Chinn J, Kelsey AJ, Lai KT, Zhao W, Horvath P, Tifrea D, Grigorian A, Gonzales A, Adelsohn S, Zaldivar F, Edwards R, Amin AN, Stamos MJ, Barie PS, Felgner PL, Khan S. PMID: 37194021; PMCID: PMC10186297.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    2. A Low-Cost Modular Imaging System for Rapid, Multiplexed Immunofluorescence Detection in Clinical Tissues. Int J Mol Sci. 2023 Apr 10; 24(8). Gu J, Jian H, Wei C, Shiu J, Ganesan A, Zhao W, Hedde PN. PMID: 37108170; PMCID: PMC10138925.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat. Nat Commun. 2023 02 28; 14(1):1128. Zhao W, Johnston KG, Ren H, Xu X, Nie Q. PMID: 36854676; PMCID: PMC9974942.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    4. Inferring neuron-neuron communications from single-cell transcriptomics through NeuronChat. bioRxiv. 2023 Jan 16. Zhao W, Johnston KG, Ren H, Xu X, Nie Q. PMID: 36712056; PMCID: PMC9882151.
      View in: PubMed   Mentions:
    5. Digital Protein Detection in Bulk Solutions. ACS Omega. 2022 Oct 25; 7(42):37714-37723. Beck S, Shin D, Kim SJ, Hedde PN, Zhao W. PMID: 36312374; PMCID: PMC9608401.
      View in: PubMed   Mentions:
    6. A Protein Microarray-Based Respiratory Viral Antigen Testing Platform for COVID-19 Surveillance. Biomedicines. 2022 Sep 09; 10(9). Beck S, Nakajima R, Jasinskas A, Abram TJ, Kim SJ, Bigdeli N, Tifrea DF, Hernandez-Davies J, Huw Davies D, Hedde PN, Felgner PL, Zhao W. PMID: 36140339; PMCID: PMC9496200.
      View in: PubMed   Mentions: 3  
    7. Evidence of brain-derived neurotrophic factor in ameliorating cancer-related cognitive impairment: A systematic review of human studies. Crit Rev Oncol Hematol. 2022 Aug; 176:103748. Ng DQ, Chan D, Agrawal P, Zhao W, Xu X, Acharya M, Chan A. PMID: 35718064.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Spatial transcriptomics using combinatorial fluorescence spectral and lifetime encoding, imaging and analysis. Nat Commun. 2022 01 10; 13(1):169. Vu T, Vallmitjana A, Gu J, La K, Xu Q, Flores J, Zimak J, Shiu J, Hosohama L, Wu J, Douglas C, Waterman ML, Ganesan A, Hedde PN, Gratton E, Zhao W. PMID: 35013281; PMCID: PMC8748653.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    9. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 06 03; 4(1):685. Mohammadi MR, Rodriguez SM, Luong JC, Li S, Cao R, Alshetaiwi H, Lau H, Davtyan H, Jones MB, Jafari M, Kessenbrock K, Villalta SA, de Vos P, Zhao W, Lakey JRT. PMID: 34083739; PMCID: PMC8175379.
      View in: PubMed   Mentions: 14  Translation:HumansAnimalsCells
    10. Therapeutic implications of transplanted-cell death. Nat Biomed Eng. 2021 05; 5(5):379-384. Wagoner ZW, Zhao W. PMID: 34002064.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    11. Epigenetic silencing directs expression heterogeneity of stably integrated multi-transcript unit genetic circuits. Sci Rep. 2021 01 28; 11(1):2424. Zimak J, Wagoner ZW, Nelson N, Waechtler B, Schlosser H, Kopecky M, Wu J, Zhao W. PMID: 33510302; PMCID: PMC7844226.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    12. β-endorphin at the intersection of pain and cancer progression: Preclinical evidence. Neurosci Lett. 2021 01 23; 744:135601. Argueta DA, Aich A, Lei J, Kiven S, Nguyen A, Wang Y, Gu J, Zhao W, Gupta K. PMID: 33387660; PMCID: PMC7837276.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Silver Sulfide Nanoparticles Reduce Nitrous Oxide Emissions by Inhibiting Denitrification in the Earthworm Gut. Environ Sci Technol. 2020 09 15; 54(18):11146-11154. Wu J, Bai Y, Lu B, Zhao W, Forstner C, Menzies NW, Bertsch PM, Wang P, Kopittke PM. PMID: 32790293.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    14. A modular microarray imaging system for highly specific COVID-19 antibody testing. Lab Chip. 2020 09 21; 20(18):3302-3309. Hedde PN, Abram TJ, Jain A, Nakajima R, Ramiro de Assis R, Pearce T, Jasinskas A, Toosky MN, Khan S, Felgner PL, Gratton E, Zhao W. PMID: 32743622; PMCID: PMC8462184.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansPHPublic Health
    15. CAR-T design: Elements and their synergistic function. EBioMedicine. 2020 Aug; 58:102931. Jayaraman J, Mellody MP, Hou AJ, Desai RP, Fung AW, Pham AHT, Chen YY, Zhao W. PMID: 32739874; PMCID: PMC7393540.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansCells
    16. Rapid isolation of rare targets from large fluid volumes. Sci Rep. 2020 07 27; 10(1):12458. Hedde PN, Bouzin M, Abram TJ, Chen X, Toosky MN, Vu T, Li Y, Zhao W, Gratton E. PMID: 32719382; PMCID: PMC7385493.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    17. Optimization of a syngeneic murine model of bone metastasis. J Bone Oncol. 2020 Aug; 23:100298. Farhoodi HP, Segaliny AI, Wagoner ZW, Cheng JL, Liu L, Zhao W. PMID: 32642420; PMCID: PMC7334391.
      View in: PubMed   Mentions: 5  
    18. A Modular Microarray Imaging System for Highly Specific COVID-19 Antibody Testing. bioRxiv. 2020 May 23. Hedde PN, Abram TJ, Jain A, Nakajima R, de Assis RR, Pearce T, Jasinskas A, Toosky MN, Khan S, Felgner PL, Gratton E, Zhao W. PMID: 32511369; PMCID: PMC7263497.
      View in: PubMed   Mentions:
    19. Controlled Release of Stem Cell Secretome Attenuates Inflammatory Response against Implanted Biomaterials. Adv Healthc Mater. 2020 06; 9(12):e1901874. Mohammadi M, Luong JC, Rodriguez SM, Cao R, Wheeler AE, Lau H, Li S, Shabestari SK, Chadarevian JP, Alexander M, de Vos P, Zhao W, Lakey JRT. PMID: 32419390.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    20. Preferences of Type 1 Diabetic Patients on Devices for Islet Transplantation. Cell Transplant. 2020 Jan-Dec; 29:963689720952343. Mohammadi MR, Dehkordi-Vakil F, Ricks-Oddie J, Mansfield R, Kashmiri H, Daniels M, Zhao W, Lakey JR. PMID: 33023311; PMCID: PMC7784499.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Isolation and characterization of microvesicles from mesenchymal stem cells. Methods. 2020 05 01; 177:50-57. Mohammadi MR, Riazifar M, Pone EJ, Yeri A, Van Keuren-Jensen K, Lässer C, Lotvall J, Zhao W. PMID: 31669353; PMCID: PMC7182501.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. Meta-analysis of preclinical studies of mesenchymal stromal cells to treat rheumatoid arthritis. EBioMedicine. 2019 Sep; 47:563-577. Liu L, Wong CW, Han M, Farhoodi HP, Liu G, Liu Y, Liao W, Zhao W. PMID: 31501076; PMCID: PMC6796567.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    23. mRNA rescues neonatal acidemia while mice report no aftereffects. EBioMedicine. 2019 Aug; 46:23-24. Zimak J, Shang Y, Zhao W. PMID: 31375424; PMCID: PMC6711884.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    24. Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells. EBioMedicine. 2019 Jul; 45:39-57. Segaliny AI, Cheng JL, Farhoodi HP, Toledano M, Yu CC, Tierra B, Hildebrand L, Liu L, Liao MJ, Cho J, Liu D, Sun L, Gulsen G, Su MY, Sah RL, Zhao W. PMID: 31281099; PMCID: PMC6642316.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    25. Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes. Cell Tissue Res. 2019 Nov; 378(2):155-162. Stiner R, Alexander M, Liu G, Liao W, Liu Y, Yu J, Pone EJ, Zhao W, Lakey JRT. PMID: 31209568.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders. ACS Nano. 2019 06 25; 13(6):6670-6688. Riazifar M, Mohammadi MR, Pone EJ, Yeri A, Lässer C, Segaliny AI, McIntyre LL, Shelke GV, Hutchins E, Hamamoto A, Calle EN, Crescitelli R, Liao W, Pham V, Yin Y, Jayaraman J, Lakey JRT, Walsh CM, Van Keuren-Jensen K, Lotvall J, Zhao W. PMID: 31117376; PMCID: PMC6880946.
      View in: PubMed   Mentions: 208     Fields:    Translation:HumansAnimalsCells
    27. Fluorescence lifetime detection with particle counting devices. Biomed Opt Express. 2019 Mar 01; 10(3):1223-1233. Hedde PN, Abram T, Vu T, Zhao W, Gratton E. PMID: 30891341; PMCID: PMC6420272.
      View in: PubMed   Mentions: 3  
    28. Functional TCR T cell screening using single-cell droplet microfluidics. Lab Chip. 2018 12 04; 18(24):3733-3749. Segaliny AI, Li G, Kong L, Ren C, Chen X, Wang JK, Baltimore D, Wu G, Zhao W. PMID: 30397689; PMCID: PMC6279597.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    29. Targeting Biophysical Cues: a Niche Approach to Study, Diagnose, and Treat Cancer. Trends Cancer. 2018 04; 4(4):268-271. Zhang SX, Liu L, Zhao W. PMID: 29606309; PMCID: PMC6226275.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Emerging Microtechnologies and Automated Systems for Rapid Bacterial Identification and Antibiotic Susceptibility Testing. SLAS Technol. 2017 12; 22(6):585-608. Li Y, Yang X, Zhao W. PMID: 28850804; PMCID: PMC5835395.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    31. Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 07 26; 9(400). Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W. PMID: 28747514; PMCID: PMC5890431.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    32. A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions. BMC Syst Biol. 2017 May 16; 11(1):55. Peng T, Liu L, MacLean AL, Wong CW, Zhao W, Nie Q. PMID: 28511648; PMCID: PMC5434622.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    33. Polymerization-Induced Self-Assembly (PISA) - Control over the Morphology of 19F-Containing Polymeric Nano-objects for Cell Uptake and Tracking. Biomacromolecules. 2017 04 10; 18(4):1145-1156. Zhao W, Ta HT, Zhang C, Whittaker AK. PMID: 28339189.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    34. Stem Cell Extracellular Vesicles: Extended Messages of Regeneration. Annu Rev Pharmacol Toxicol. 2017 01 06; 57:125-154. Riazifar M, Pone EJ, Lötvall J, Zhao W. PMID: 27814025; PMCID: PMC5360275.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansAnimalsCells
    35. Elucidation of Exosome Migration across the Blood-Brain Barrier Model In Vitro. Cell Mol Bioeng. 2016 Dec; 9(4):509-529. Chen CC, Liu L, Ma F, Wong CW, Guo XE, Chacko JV, Farhoodi HP, Zhang SX, Zimak J, Ségaliny A, Riazifar M, Pham V, Digman MA, Pone EJ, Zhao W. PMID: 28392840; PMCID: PMC5382965.
      View in: PubMed   Mentions: 233  
    36. Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis. Biomaterials. 2016 Jan; 77:87-97. Liao W, Pham V, Liu L, Riazifar M, Pone EJ, Zhang SX, Ma F, Lu M, Walsh CM, Zhao W. PMID: 26584349; PMCID: PMC4684451.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    37. Floating Droplet Array: An Ultrahigh-Throughput Device for Droplet Trapping, Real-time Analysis and Recovery. Micromachines (Basel). 2015 Oct; 6(10):1469-1482. Labanieh L, Nguyen TN, Zhao W, Kang DK. PMID: 27134760; PMCID: PMC4849166.
      View in: PubMed   Mentions: 15  
    38. Exogenous marker-engineered mesenchymal stem cells detect cancer and metastases in a simple blood assay. Stem Cell Res Ther. 2015 Sep 21; 6:181. Liu L, Zhang SX, Aeran R, Liao W, Lu M, Polovin G, Pone EJ, Zhao W. PMID: 26391980; PMCID: PMC4578609.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    39. Facile supermolecular aptamer inhibitors of L-selectin. PLoS One. 2015; 10(3):e0123034. Chang EK, Eckert MA, Ali MM, Riazifar H, Pone EJ, Liu L, Zhao W. PMID: 25826688; PMCID: PMC4380364.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. Rapid detection of single bacteria in unprocessed blood using Integrated Comprehensive Droplet Digital Detection. Nat Commun. 2014 Nov 13; 5:5427. Kang DK, Ali MM, Zhang K, Huang SS, Peterson E, Digman MA, Gratton E, Zhao W. PMID: 25391809; PMCID: PMC4243214.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    41. DNA-scaffolded multivalent ligands to modulate cell function. Chembiochem. 2014 Jun 16; 15(9):1268-73. Zhang Z, Eckert MA, Ali MM, Liu L, Kang DK, Chang E, Pone EJ, Sender LS, Fruman DA, Zhao W. PMID: 24803415.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    42. Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine. Chem Soc Rev. 2014 May 21; 43(10):3324-41. Ali MM, Li F, Zhang Z, Zhang K, Kang DK, Ankrum JA, Le XC, Zhao W. PMID: 24643375.
      View in: PubMed   Mentions: 202     Fields:    Translation:Cells
    43. Mesenchymal stem cell biodistribution, migration, and homing in vivo. Stem Cells Int. 2014; 2014:292109. Zhao W, Phinney DG, Bonnet D, Dominici M, Krampera M. PMID: 24738002; PMCID: PMC3967815.
      View in: PubMed   Mentions: 26  
    44. Meta-analysis of preclinical studies of mesenchymal stromal cells for ischemic stroke. Neurology. 2014 Apr 08; 82(14):1277-86. Vu Q, Xie K, Eckert M, Zhao W, Cramer SC. PMID: 24610327; PMCID: PMC4001201.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    45. A polyvalent aptamer system for targeted drug delivery. Biomaterials. 2013 Dec; 34(37):9728-35. Zhang Z, Ali MM, Eckert MA, Kang DK, Chen YY, Sender LS, Fruman DA, Zhao W. PMID: 24044994.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    46. From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood-brain barrier? Stem Cells Int. 2013; 2013:435093. Liu L, Eckert MA, Riazifar H, Kang DK, Agalliu D, Zhao W. PMID: 23997771; PMCID: PMC3753739.
      View in: PubMed   Mentions: 60  
    47. Novel molecular and nanosensors for in vivo sensing. Theranostics. 2013; 3(8):583-94. Eckert MA, Vu PQ, Zhang K, Kang D, Ali MM, Xu C, Zhao W. PMID: 23946824; PMCID: PMC3741607.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    48. Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. J Cereb Blood Flow Metab. 2013 Sep; 33(9):1322-34. Eckert MA, Vu Q, Xie K, Yu J, Liao W, Cramer SC, Zhao W. PMID: 23756689; PMCID: PMC3764389.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    49. Cell-surface sensors: lighting the cellular environment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Sep-Oct; 4(5):547-61. Ali MM, Kang DK, Tsang K, Fu M, Karp JM, Zhao W. PMID: 22761045; PMCID: PMC3425956.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    50. Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors. Cancer Res. 2010 Jun 01; 70(11):4666-75. Doghman M, El Wakil A, Cardinaud B, Thomas E, Wang J, Zhao W, Peralta-Del Valle MH, Figueiredo BC, Zambetti GP, Lalli E. PMID: 20484036; PMCID: PMC2880211.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimals
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