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Cummings, Brian J

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentPhysical Medicine and Rehabilitation
Address1001 Health Sciences Road
CA 92697-3950
Phone(949) 824-3254
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    Collapse Research 
    Collapse Research Activities and Funding
    Human neural stem cell therapy for the treatment of cervical spinal cord injury (
    NIH/NINDS U01NS079420Sep 1, 2013 - Aug 31, 2016
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Anzalone A, Chacko JV, Nishi RA, Dumont C, Smith D, Shea LD, Digman MA, Cummings B, Anderson AJ. Feasibility study on mouse live imaging after spinal cord injury and poly(lactide-co-glycolide) bridge implantation. J Biomed Opt. 2018 Jun; 23(6):1-6. PMID: 29959835.
      View in: PubMed
    2. Park J, Decker JT, Margul DJ, Smith DR, Cummings B, Anderson AJ, Shea LD. Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury. Mol Ther. 2018 Apr 27. PMID: 29778523.
      View in: PubMed
    3. Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings B. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits. ASN Neuro. 2018 Jan-Dec; 10:1759091418781921. PMID: 29932344.
      View in: PubMed
    4. Piltti KM, Cummings B, Carta K, Manughian-Peter A, Worne CL, Singh K, Ong D, Maksymyuk Y, Khine M, Anderson AJ. Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells - Tools for analyzing dynamics of cell cycle, migration, and lineage selection. Methods. 2018 Jan 15; 133:81-90. PMID: 29050826.
      View in: PubMed
    5. Hooshmand MJ, Nguyen HX, Piltti KM, Benavente F, Hong S, Flanagan L, Uchida N, Cummings B, Anderson AJ. Neutrophils Induce Astroglial Differentiation and Migration of Human Neural Stem Cells via C1q and C3a Synthesis. J Immunol. 2017 08 01; 199(3):1069-1085. PMID: 28687659.
      View in: PubMed
    6. Beretta S, Cunningham KM, Haus DL, Gold EM, Perez H, López-Velázquez L, Cummings B. Effects of Human ES-Derived Neural Stem Cell Transplantation and Kindling in a Rat Model of Traumatic Brain Injury. Cell Transplant. 2017 Jul; 26(7):1247-1261. PMID: 28933218.
      View in: PubMed
    7. Piltti KM, Funes GM, Avakian SN, Salibian AA, Huang KI, Carta K, Kamei N, Flanagan LA, Monuki ES, Uchida N, Cummings B, Anderson AJ. Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury. Stem Cell Reports. 2017 06 06; 8(6):1534-1548. PMID: 28479305.
      View in: PubMed
    8. Abud EM, Ramirez RN, Martinez ES, Healy LM, Nguyen CHH, Newman SA, Yeromin AV, Scarfone VM, Marsh SE, Fimbres C, Caraway CA, Fote GM, Madany AM, Agrawal A, Kayed R, Gylys KH, Cahalan MD, Cummings B, Antel JP, Mortazavi A, Carson MJ, Poon WW, Blurton-Jones M. iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 2017 Apr 19; 94(2):278-293.e9. PMID: 28426964.
      View in: PubMed
    9. Monuki ES, Anderson AJ, Blurton-Jones M, Cummings B. Response to StemCells Inc. Stem Cell Reports. 2017 Feb 14; 8(2):195-197. PMID: 28199827.
      View in: PubMed
    10. Anderson AJ, Piltti KM, Hooshmand MJ, Nishi RA, Cummings B. Preclinical Efficacy Failure of Human CNS-Derived Stem Cells for Use in the Pathway Study of Cervical Spinal Cord Injury. Stem Cell Reports. 2017 02 14; 8(2):249-263. PMID: 28199829.
      View in: PubMed
    11. Anderson AJ, Cummings B. Achieving Informed Consent for Cellular Therapies: A Preclinical Translational Research Perspective on Regulations versus a Dose of Reality. J Law Med Ethics. 2016 09; 44(3):394-401. PMID: 27587445.
      View in: PubMed
    12. Haus DL, López-Velázquez L, Gold EM, Cunningham KM, Perez H, Anderson AJ, Cummings B. Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury. Exp Neurol. 2016 07; 281:1-16. PMID: 27079998.
      View in: PubMed
    13. Koliatsos VE, Xu L, Cummings B. Stem cell therapies for traumatic brain injury. Regen Med. 2015 Nov; 10(8):917-20. PMID: 26542417.
      View in: PubMed
    14. Chang J, Phelan M, Cummings B. A meta-analysis of efficacy in pre-clinical human stem cell therapies for traumatic brain injury. Exp Neurol. 2015 Nov; 273:225-33. PMID: 26342754.
      View in: PubMed
    15. Piltti KM, Avakian SN, Funes GM, Hu A, Uchida N, Anderson AJ, Cummings B. Transplantation dose alters the dynamics of human neural stem cell engraftment, proliferation and migration after spinal cord injury. Stem Cell Res. 2015 Sep; 15(2):341-53. PMID: 26298025; PMCID: PMC4600655.
    16. Pawar K, Cummings B, Thomas A, Shea LD, Levine A, Pfaff S, Anderson AJ. Biomaterial bridges enable regeneration and re-entry of corticospinal tract axons into the caudal spinal cord after SCI: Association with recovery of forelimb function. Biomaterials. 2015 Oct; 65:1-12. PMID: 26134079; PMCID: PMC4523232 [Available on 10/01/16].
    17. Xu L, Ryu J, Hiel H, Menon A, Aggarwal A, Rha E, Mahairaki V, Cummings B, Koliatsos VE. Transplantation of human oligodendrocyte progenitor cells in an animal model of diffuse traumatic axonal injury: survival and differentiation. Stem Cell Res Ther. 2015 May 14; 6:93. PMID: 25971252; PMCID: PMC4453242.
    18. Haus DL, Nguyen HX, Gold EM, Kamei N, Perez H, Moore HD, Anderson AJ, Cummings B. CD133-enriched Xeno-Free human embryonic-derived neural stem cells expand rapidly in culture and do not form teratomas in immunodeficient mice. Stem Cell Res. 2014 Sep; 13(2):214-26. PMID: 25082219.
      View in: PubMed
    19. Thomas AM, Seidlits SK, Goodman AG, Kukushliev TV, Hassani DM, Cummings B, Anderson AJ, Shea LD. Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury. Integr Biol (Camb). 2014 Jul 24; 6(7):694-705. PMID: 24873988; PMCID: PMC4086750.
    20. Nguyen HX, Nekanti U, Haus DL, Funes G, Moreno D, Kamei N, Cummings B, Anderson AJ. Induction of early neural precursors and derivation of tripotent neural stem cells from human pluripotent stem cells under xeno-free conditions. J Comp Neurol. 2014 Aug 15; 522(12):2767-83. PMID: 24715528.
      View in: PubMed
    21. Sontag CJ, Uchida N, Cummings B, Anderson AJ. Injury to the spinal cord niche alters the engraftment dynamics of human neural stem cells. Stem Cell Reports. 2014 May 06; 2(5):620-32. PMID: 24936450; PMCID: PMC4050489.
    22. Tuinstra HM, Margul DJ, Goodman AG, Boehler RM, Holland SJ, Zelivyanskaya ML, Cummings B, Anderson AJ, Shea LD. Long-term characterization of axon regeneration and matrix changes using multiple channel bridges for spinal cord regeneration. Tissue Eng Part A. 2014 Mar; 20(5-6):1027-37. PMID: 24168314; PMCID: PMC3938917.
    23. Piltti KM, Salazar DL, Uchida N, Cummings B, Anderson AJ. Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem Cells Transl Med. 2013 Dec; 2(12):961-74. PMID: 24191264; PMCID: PMC3841091.
    24. Sontag CJ, Nguyen HX, Kamei N, Uchida N, Anderson AJ, Cummings B. Immunosuppressants affect human neural stem cells in vitro but not in an in vivo model of spinal cord injury. Stem Cells Transl Med. 2013 Oct; 2(10):731-44. PMID: 23981724; PMCID: PMC3785258.
    25. Gold EM, Su D, López-Velázquez L, Haus DL, Perez H, Lacuesta GA, Anderson AJ, Cummings B. Functional assessment of long-term deficits in rodent models of traumatic brain injury. Regen Med. 2013 Jul; 8(4):483-516. PMID: 23826701.
      View in: PubMed
    26. Piltti KM, Salazar DL, Uchida N, Cummings B, Anderson AJ. Safety of epicenter versus intact parenchyma as a transplantation site for human neural stem cells for spinal cord injury therapy. Stem Cells Transl Med. 2013 Mar; 2(3):204-16. PMID: 23413374; PMCID: PMC3659765.
    27. Thomas AM, Kubilius MB, Holland SJ, Seidlits SK, Boehler RM, Anderson AJ, Cummings B, Shea LD. Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury. Biomaterials. 2013 Mar; 34(9):2213-20. PMID: 23290832; PMCID: PMC3552139.
    28. Uchida N, Chen K, Dohse M, Hansen KD, Dean J, Buser JR, Riddle A, Beardsley DJ, Wan Y, Gong X, Nguyen T, Cummings B, Anderson AJ, Tamaki SJ, Tsukamoto A, Weissman IL, Matsumoto SG, Sherman LS, Kroenke CD, Back SA. Human neural stem cells induce functional myelination in mice with severe dysmyelination. Sci Transl Med. 2012 Oct 10; 4(155):155ra136. PMID: 23052293; PMCID: PMC3864816.
    29. Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings B, Glabe CG, Muchowski PJ, Thompson LM. Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules. J Huntingtons Dis. 2012; 1(1):119-32. PMID: 24086178; PMCID: PMC3786168.
    30. Tuinstra HM, Aviles MO, Shin S, Holland SJ, Zelivyanskaya ML, Fast AG, Ko SY, Margul DJ, Bartels AK, Boehler RM, Cummings B, Anderson AJ, Shea LD. Multifunctional, multichannel bridges that deliver neurotrophin encoding lentivirus for regeneration following spinal cord injury. Biomaterials. 2012 Feb; 33(5):1618-26. PMID: 22130565; PMCID: PMC3237872.
    31. Anderson AJ, Haus DL, Hooshmand MJ, Perez H, Sontag CJ, Cummings B. Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient? Regen Med. 2011 May; 6(3):367-406. PMID: 21548741; PMCID: PMC3403688.
    32. Salazar DL, Uchida N, Hamers FP, Cummings B, Anderson AJ. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS One. 2010 Aug 18; 5(8):e12272. PMID: 20806064; PMCID: PMC2923623.
    33. Luchetti S, Beck KD, Galvan MD, Silva R, Cummings B, Anderson AJ. Comparison of immunopathology and locomotor recovery in C57BL/6, BUB/BnJ, and NOD-SCID mice after contusion spinal cord injury. J Neurotrauma. 2010 Feb; 27(2):411-21. PMID: 19831737; PMCID: PMC2834443.
    34. Yang Y, De Laporte L, Zelivyanskaya ML, Whittlesey KJ, Anderson AJ, Cummings B, Shea LD. Multiple channel bridges for spinal cord injury: cellular characterization of host response. Tissue Eng Part A. 2009 Nov; 15(11):3283-95. PMID: 19382871; PMCID: PMC2792065.
    35. Nasonkin I, Mahairaki V, Xu L, Hatfield G, Cummings B, Eberhart C, Ryugo DK, Maric D, Bar E, Koliatsos VE. Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum. Stem Cells. 2009 Oct; 27(10):2414-26. PMID: 19609935; PMCID: PMC2906132.
    36. Hooshmand MJ, Sontag CJ, Uchida N, Tamaki S, Anderson AJ, Cummings B. Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS One. 2009 Jun 11; 4(6):e5871. PMID: 19517014; PMCID: PMC2690693.
    37. De Laporte L, Yang Y, Zelivyanskaya ML, Cummings B, Anderson AJ, Shea LD. Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury. Mol Ther. 2009 Feb; 17(2):318-26. PMID: 19050701; PMCID: PMC2835056.
    38. Cummings B, Engesser-Cesar C, Cadena G, Anderson AJ. Adaptation of a ladder beam walking task to assess locomotor recovery in mice following spinal cord injury. Behav Brain Res. 2007 Feb 27; 177(2):232-41. PMID: 17197044; PMCID: PMC1892162.
    39. Cummings B, Uchida N, Tamaki SJ, Anderson AJ. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol Res. 2006 Jul; 28(5):474-81. PMID: 16808875.
      View in: PubMed
    40. Luchetti S, di Michele F, Romeo E, Brusa L, Bernardi G, Cummings B, Longone P. Comparative non-radioactive RT-PCR assay: an approach to study the neurosteroids biosynthetic pathway in humans. J Neurosci Methods. 2006 Jun 15; 153(2):290-8. PMID: 16378642.
      View in: PubMed
    41. Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. BioVision: an application for the automated image analysis of histological sections. Neurobiol Aging. 2006 Oct; 27(10):1462-76. PMID: 16271803.
      View in: PubMed
    42. Cummings B, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):14069-74. PMID: 16172374; PMCID: PMC1216836.
    43. Adlard PA, Cummings B. Alzheimer's disease--a sum greater than its parts? Neurobiol Aging. 2004 Jul; 25(6):725-33; discussion 743-6. PMID: 15165695.
      View in: PubMed
    44. Zhao M, Cribbs DH, Anderson AJ, Cummings B, Su JH, Wasserman AJ, Cotman CW. The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain. Neurochem Res. 2003 Feb; 28(2):307-18. PMID: 12608703.
      View in: PubMed
    45. Cummings B, Mason AJ, Kim RC, Sheu PC, Anderson AJ. Optimization of techniques for the maximal detection and quantification of Alzheimer's-related neuropathology with digital imaging. Neurobiol Aging. 2002 Mar-Apr; 23(2):161-70. PMID: 11804699.
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