Lander, Arthur D.

InstitutionUniversity of California, Irvine
DepartmentDevelopmental & Cell Biology
Address2638 Biological Sciences III
Zot 2300
Irvine CA 92697
Phone(949) 824-1721
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    Collapse Research 
    Collapse Research Activities and Funding
    Complexity, Cooperation and Community in Cancer
    NIH/NCI U54CA217378Apr 1, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    Systems Biology: A Foundation for Interdisciplinary Careers
    NIH/NIGMS R25GM126365Sep 20, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Investigating the multifactorial origins of congenital heart disease
    NIH/NHLBI R01HL138659Aug 15, 2017 - May 31, 2021
    Role: Co-Principal Investigator
    Spatial Dynamics of Tissue and Organ Size Control
    NIH/NINDS R01NS095355Sep 30, 2015 - Jun 30, 2020
    Role: Principal Investigator
    A National Short Course in Systems Biology: Tackling Spatial Dynamics in Cells an
    NIH/NIGMS R25GM096989Aug 1, 2011 - May 31, 2016
    Role: Co-Principal Investigator
    Feedback, lineages and cancer: A multidisciplinary approach.
    NIH/NCI RC2CA148493Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Training Program in Systems Biology of Development
    NIH/NICHD T32HD060555May 1, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Mathematical, Computational and Systems Biology
    NIH/NIBIB T32EB009418Apr 1, 2009 - Mar 31, 2020
    Role: Principal Investigator
    Systems Biology of Morphogeneisis and Spatial Information Flow
    NIH/NIGMS P50GM076516Aug 1, 2007 - Jul 31, 2017
    Role: Principal Investigator
    NIPBL, Cohesin and Related Structural Birth Defects
    NIH/NICHD P01HD052860May 1, 2006 - Jan 31, 2016
    Role: Co-Principal Investigator
    Transport and Complexity in Biological Systems
    NIH/NIGMS P20GM066051Aug 1, 2002 - Jul 31, 2007
    Role: Principal Investigator
    Principles of Robust Developmental Patterning
    NIH/NIGMS R01GM067247Jul 1, 2002 - Dec 31, 2014
    Role: Co-Principal Investigator
    Gordon Research Conference on Proteoglycans
    NIH/NICHD R13HD041976Jul 1, 2002 - Jun 30, 2003
    Role: Principal Investigator
    NIH/NICHD P01HD038761Jun 15, 2000 - May 31, 2007
    Role: Principal Investigator
    Training Program in Cellular and Molecular Neuroscience
    NIH/NINDS T32NS007444Sep 30, 1997 - Jun 30, 2010
    Role: Principal Investigator
    NIH/NINDS R01NS036049Jan 1, 1997 - Dec 31, 2001
    Role: Principal Investigator
    NIH/NEI R01EY010324Dec 1, 1993 - Nov 30, 1997
    Role: Principal Investigator
    NIH/NINDS R01NS026862Apr 1, 1990 - Mar 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Newkirk DA, Chen YY, Chien R, Zeng W, Biesinger J, Flowers E, Kawauchi S, Santos R, Calof AL, Lander AD, Xie X, Yokomori K. The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome. Clin Epigenetics. 2017; 9:89. PMID: 28855971.
      View in: PubMed
    2. Wortman JC, Nahmad M, Zhang PC, Lander AD, Yu CC. Expanding signaling-molecule wavefront model of cell polarization in the Drosophila wing primordium. PLoS Comput Biol. 2017 Jul; 13(7):e1005610. PMID: 28671940.
      View in: PubMed
    3. Hsia K, Yang MJ, Chen WM, Yao CL, Lin CH, Loong CC, Huang YL, Lin YT, Lander AD, Lee H, Lu JH. Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. Acta Biomater. 2017 03 15; 51:341-350. PMID: 28110073.
      View in: PubMed
    4. Santos R, Kawauchi S, Jacobs RE, Lopez-Burks ME, Choi H, Wikenheiser J, Hallgrimsson B, Jamniczky HA, Fraser SE, Lander AD, Calof AL. Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects. PLoS Biol. 2016 Sep; 14(9):e2000197. PMID: 27606604; PMCID: PMC5016002.
    5. Wilkins JF, McHale PT, Gervin J, Lander AD. Survival of the Curviest: Noise-Driven Selection for Synergistic Epistasis. PLoS Genet. 2016 Apr; 12(4):e1006003. PMID: 27123867; PMCID: PMC4849581.
    6. Lopez-Burks ME, Santos R, Kawauchi S, Calof AL, Lander AD. Genetic enhancement of limb defects in a mouse model of Cornelia de Lange syndrome. Am J Med Genet C Semin Med Genet. 2016 06; 172(2):146-54. PMID: 27120109.
      View in: PubMed
    7. Kawauchi S, Santos R, Muto A, Lopez-Burks ME, Schilling TF, Lander AD, Calof AL. Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange Syndrome. Am J Med Genet C Semin Med Genet. 2016 06; 172(2):138-45. PMID: 27120001.
      View in: PubMed
    8. Kunche S, Yan H, Calof AL, Lowengrub JS, Lander AD. Feedback, Lineages and Self-Organizing Morphogenesis. PLoS Comput Biol. 2016 Mar; 12(3):e1004814. PMID: 26989903; PMCID: PMC4798729.
    9. Kline AD, Calof AL, Lander AD, Gerton JL, Krantz ID, Dorsett D, Deardorff MA, Blagowidow N, Yokomori K, Shirahige K, Santos R, Woodman J, Megee PC, O'Connor JT, Egense A, Noon S, Belote M, Goodban MT, Hansen BD, Timmons JG, Musio A, Ishman SL, Bryan Y, Wu Y, Bettini LR, Mehta D, Zakari M, Mills JA, Srivastava S, Haaland RE. Clinical, developmental and molecular update on Cornelia de Lange syndrome and the cohesin complex: abstracts from the 2014 Scientific and Educational Symposium. Am J Med Genet A. 2015 Jun; 167(6):1179-92. PMID: 25899772.
      View in: PubMed
    10. Chen CC, Wang L, Plikus MV, Jiang TX, Murray PJ, Ramos R, Guerrero-Juarez CF, Hughes MW, Lee OK, Shi S, Widelitz RB, Lander AD, Chuong CM. Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell. 2015 Apr 09; 161(2):277-90. PMID: 25860610; PMCID: PMC4393531.
    11. Buzi G, Lander AD, Khammash M. Cell lineage branching as a strategy for proliferative control. BMC Biol. 2015 Feb 19; 13:13. PMID: 25857410; PMCID: PMC4378012.
    12. Lo WC, Zhou S, Wan FY, Lander AD, Nie Q. Robust and precise morphogen-mediated patterning: trade-offs, constraints and mechanisms. J R Soc Interface. 2015 Jan 06; 12(102):20141041. PMID: 25551154; PMCID: PMC4277094.
    13. Muto A, Ikeda S, Lopez-Burks ME, Kikuchi Y, Calof AL, Lander AD, Schilling TF. Nipbl and mediator cooperatively regulate gene expression to control limb development. PLoS Genet. 2014 Sep; 10(9):e1004671. PMID: 25255084; PMCID: PMC4177752.
    14. McHale PT, Lander AD. The protective role of symmetric stem cell division on the accumulation of heritable damage. PLoS Comput Biol. 2014 Aug; 10(8):e1003802. PMID: 25121484; PMCID: PMC4133021.
    15. Lander AD. Making sense in biology: an appreciation of Julian Lewis. BMC Biol. 2014 Aug 02; 12:57. PMID: 25185109; PMCID: PMC4243962.
    16. Srinivasan S, Hu JS, Currle DS, Fung ES, Hayes WB, Lander AD, Monuki ES. A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain. PLoS Comput Biol. 2014 Feb; 10(2):e1003463. PMID: 24550718; PMCID: PMC3923663.
    17. Konstorum A, Sprowl SA, Waterman ML, Lander AD, Lowengrub JS. Predicting mechanism of biphasic growth factor action on tumor growth using a multi-species model with feedback control. J Coupled Syst Multiscale Dyn. 2013 Dec 01; 1(4):459-467. PMID: 25075381.
      View in: PubMed
    18. Remeseiro S, Cuadrado A, Kawauchi S, Calof AL, Lander AD, Losada A. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochim Biophys Acta. 2013 Dec; 1832(12):2097-102. PMID: 23920377; PMCID: PMC3825806.
    19. Lander AD. How cells know where they are. Science. 2013 Feb 22; 339(6122):923-7. PMID: 23430648; PMCID: PMC3932337.
    20. Schilling TF, Nie Q, Lander AD. Dynamics and precision in retinoic acid morphogen gradients. Curr Opin Genet Dev. 2012 Dec; 22(6):562-9. PMID: 23266215; PMCID: PMC3790664.
    21. Zhang L, Lander AD, Nie Q. A reaction-diffusion mechanism influences cell lineage progression as a basis for formation, regeneration, and stability of intestinal crypts. BMC Syst Biol. 2012 Jul 31; 6:93. PMID: 22849824; PMCID: PMC3434027.
    22. Cai AQ, Radtke K, Linville A, Lander AD, Nie Q, Schilling TF. Cellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish. Development. 2012 Jun; 139(12):2150-5. PMID: 22619388; PMCID: PMC3357909.
    23. Kim MS, Kim JR, Kim D, Lander AD, Cho KH. Spatiotemporal network motif reveals the biological traits of developmental gene regulatory networks in Drosophila melanogaster. BMC Syst Biol. 2012 May 01; 6:31. PMID: 22548745; PMCID: PMC3434043.
    24. Zhou S, Lo WC, Suhalim JL, Digman MA, Gratton E, Nie Q, Lander AD. Free extracellular diffusion creates the Dpp morphogen gradient of the Drosophila wing disc. Curr Biol. 2012 Apr 24; 22(8):668-75. PMID: 22445299; PMCID: PMC3338872.
    25. Lander AD, Kimble J, Clevers H, Fuchs E, Montarras D, Buckingham M, Calof AL, Trumpp A, Oskarsson T. What does the concept of the stem cell niche really mean today? BMC Biol. 2012 Mar 09; 10:19. PMID: 22405133; PMCID: PMC3298504.
    26. Nahmad M, Lander AD. Spatiotemporal mechanisms of morphogen gradient interpretation. Curr Opin Genet Dev. 2011 Dec; 21(6):726-31. PMID: 22033220; PMCID: PMC3423890.
    27. Muto A, Calof AL, Lander AD, Schilling TF. Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. 2011 Oct; 9(10):e1001181. PMID: 22039349; PMCID: PMC3201921.
    28. Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct; 138(19):4131-42. PMID: 21852401; PMCID: PMC3171217.
    29. Lander AD. The individuality of stem cells. BMC Biol. 2011 Jun 07; 9:40. PMID: 21649941; PMCID: PMC3110137.
    30. Lei J, Wan FY, Lander AD, Nie Q. ROBUSTNESS OF SIGNALING GRADIENT IN DROSOPHILA WING IMAGINAL DISC. Discrete Continuous Dyn Syst Ser B. 2011 Jun; 16(3):835-866. PMID: 24098092.
      View in: PubMed
    31. Chien R, Zeng W, Kawauchi S, Bender MA, Santos R, Gregson HC, Schmiesing JA, Newkirk DA, Kong X, Ball AR, Calof AL, Lander AD, Groudine MT, Yokomori K. Cohesin mediates chromatin interactions that regulate mammalian ß-globin expression. J Biol Chem. 2011 May 20; 286(20):17870-8. PMID: 21454523; PMCID: PMC3093862.
    32. Lander AD. Pattern, growth, and control. Cell. 2011 Mar 18; 144(6):955-69. PMID: 21414486; PMCID: PMC3128888.
    33. Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q. Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17; 99(10):3145-54. PMID: 21081061; PMCID: PMC2980753.
    34. Kuo WJ, Digman MA, Lander AD. Heparan sulfate acts as a bone morphogenetic protein coreceptor by facilitating ligand-induced receptor hetero-oligomerization. Mol Biol Cell. 2010 Nov 15; 21(22):4028-41. PMID: 20861306; PMCID: PMC2982130.
    35. Potkin SG, Macciardi F, Guffanti G, Fallon JH, Wang Q, Turner JA, Lakatos A, Miles MF, Lander A, Vawter MP, Xie X. Identifying gene regulatory networks in schizophrenia. Neuroimage. 2010 Nov 15; 53(3):839-47. PMID: 20600988; PMCID: PMC3055795.
    36. Lander AD. The edges of understanding. BMC Biol. 2010 Apr 12; 8:40. PMID: 20385033; PMCID: PMC2864098.
    37. Lander AD. The 'stem cell' concept: is it holding us back? J Biol. 2009 Sep 21; 8(8):70. PMID: 19769787; PMCID: PMC2776917.
    38. Kawauchi S, Calof AL, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD. Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. PLoS Genet. 2009 Sep; 5(9):e1000650. PMID: 19763162; PMCID: PMC2730539.
    39. Jen YH, Musacchio M, Lander AD. Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. Neural Dev. 2009 Sep 04; 4:33. PMID: 19732411; PMCID: PMC2746204.
    40. Lander AD, Lo WC, Nie Q, Wan FY. The measure of success: constraints, objectives, and tradeoffs in morphogen-mediated patterning. Cold Spring Harb Perspect Biol. 2009 Jul; 1(1):a002022. PMID: 20066078; PMCID: PMC2742077.
    41. Beites CL, Hollenbeck PL, Kim J, Lovell-Badge R, Lander AD, Calof AL. Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue. Development. 2009 Jul; 136(13):2187-97. PMID: 19474151; PMCID: PMC2729339.
    42. Kawauchi S, Kim J, Santos R, Wu HH, Lander AD, Calof AL. Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development. 2009 May; 136(9):1453-64. PMID: 19297409; PMCID: PMC2674256.
    43. Lander AD, Gokoffski KK, Wan FY, Nie Q, Calof AL. Cell lineages and the logic of proliferative control. PLoS Biol. 2009 Jan 20; 7(1):e15. PMID: 19166268; PMCID: PMC2628408.
    44. Lo WC, Chou CS, Gokoffski KK, Wan FY, Lander AD, Calof AL, Nie Q. Feedback regulation in multistage cell lineages. Math Biosci Eng. 2009 Jan; 6(1):59-82. PMID: 19292508; PMCID: PMC2756546.
    45. Whipple CA, Lander AD, Korc M. Discovery of a novel molecule that regulates tumor growth and metastasis. ScientificWorldJournal. 2008 Dec 14; 8:1250-3. PMID: 19082421.
      View in: PubMed
    46. Aikawa T, Whipple CA, Lopez ME, Gunn J, Young A, Lander AD, Korc M. Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells. J Clin Invest. 2008 Jan; 118(1):89-99. PMID: 18064304; PMCID: PMC2117766.
    47. White RJ, Nie Q, Lander AD, Schilling TF. Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo. PLoS Biol. 2007 Nov; 5(11):e304. PMID: 18031199; PMCID: PMC2080651.
    48. Zhang YT, Lander AD, Nie Q. Computational analysis of BMP gradients in dorsal-ventral patterning of the zebrafish embryo. J Theor Biol. 2007 Oct 21; 248(4):579-89. PMID: 17673236; PMCID: PMC4151269.
    49. Lander AD. Morpheus unbound: reimagining the morphogen gradient. Cell. 2007 Jan 26; 128(2):245-56. PMID: 17254964.
      View in: PubMed
    50. Ding K, Lopez-Burks M, Sánchez-Duran JA, Korc M, Lander AD. Growth factor-induced shedding of syndecan-1 confers glypican-1 dependence on mitogenic responses of cancer cells. J Cell Biol. 2005 Nov 21; 171(4):729-38. PMID: 16286510; PMCID: PMC2171561.
    51. Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. GDF11 controls the timing of progenitor cell competence in developing retina. Science. 2005 Jun 24; 308(5730):1927-30. PMID: 15976303.
      View in: PubMed
    52. Mizutani CM, Nie Q, Wan FY, Zhang YT, Vilmos P, Sousa-Neves R, Bier E, Marsh JL, Lander AD. Formation of the BMP activity gradient in the Drosophila embryo. Dev Cell. 2005 Jun; 8(6):915-24. PMID: 15935780; PMCID: PMC1829168.
    53. Lander AD, Nie Q, Wan FY. Spatially distributed morphogen production and morphogen gradient formation. Math Biosci Eng. 2005 Apr; 2(2):239-62. PMID: 20369921.
      View in: PubMed
    54. Lander AD. A calculus of purpose. PLoS Biol. 2004 Jun; 2(6):e164. PMID: 15208717; PMCID: PMC423139.
    55. Krantz ID, McCallum J, DeScipio C, Kaur M, Gillis LA, Yaeger D, Jukofsky L, Wasserman N, Bottani A, Morris CA, Nowaczyk MJ, Toriello H, Bamshad MJ, Carey JC, Rappaport E, Kawauchi S, Lander AD, Calof AL, Li HH, Devoto M, Jackson LG. Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B. Nat Genet. 2004 Jun; 36(6):631-5. PMID: 15146186; PMCID: PMC4902017.
    56. Murray RC, Navi D, Fesenko J, Lander AD, Calof AL. Widespread defects in the primary olfactory pathway caused by loss of Mash1 function. J Neurosci. 2003 Mar 01; 23(5):1769-80. PMID: 12629181.
      View in: PubMed
    57. Lander AD, Nie Q, Wan FY. Do morphogen gradients arise by diffusion? Dev Cell. 2002 Jun; 2(6):785-96. PMID: 12062090.
      View in: PubMed
    58. Lander AD, Selleck SB. The elusive functions of proteoglycans: in vivo veritas. J Cell Biol. 2000 Jan 24; 148(2):227-32. PMID: 10648554; PMCID: PMC2174291.
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