Glabe, Charles

InstitutionUniversity of California, Irvine
DepartmentMolecular Biology & Biochem
Address3228 McGaugh Hall
Zot 3900
CA 92697
Phone(949) 824-6081, 4229
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH/NIA R01AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics
    NIH/NIA R01AG056507Jul 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics
    NIH/NIA R56AG056507Sep 15, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Novel nuclear and intracellular pathology in early AD
    NIH/NIA R21AG045729May 1, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Structure and conformational diversity of amyloid oligomers
    NIH/NIA R01AG033069Apr 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    NIH/NINDS R01NS038298Dec 1, 1998 - Nov 30, 2004
    Role: Principal Investigator
    Structure of Amyloid A Beta &Fibril Assembly Dynamics
    NIH/NINDS R01NS031230Sep 1, 1993 - Feb 28, 2008
    Role: Principal Investigator
    NIH/NICHD R01HD021379Jan 1, 1983 - Dec 31, 1999
    Role: Principal Investigator
    NIH/NICHD R01HD017396Jan 1, 1983 - Jun 30, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sosna J, Philipp S, Albay R, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe C. Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Mol Neurodegener. 2018 Mar 01; 13(1):11. PMID: 29490706.
      View in: PubMed
    2. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe C, Jiang L, Gonen T, Eisenberg DS. Common fibrillar spines of amyloid-ß and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 Feb 23; 293(8):2888-2902. PMID: 29282295.
      View in: PubMed
    3. Hatami A, Monjazeb S, Milton S, Glabe C. Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-ß Peptide. J Biol Chem. 2017 02 24; 292(8):3172-3185. PMID: 28049728.
      View in: PubMed
    4. Wälti MA, Ravotti F, Arai H, Glabe C, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R. Atomic-resolution structure of a disease-relevant Aß(1-42) amyloid fibril. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):E4976-84. PMID: 27469165; PMCID: PMC5003276.
    5. Breydo L, Kurouski D, Rasool S, Milton S, Wu JW, Uversky VN, Lednev IK, Glabe C. Structural differences between amyloid beta oligomers. Biochem Biophys Res Commun. 2016 09 02; 477(4):700-705. PMID: 27363332.
      View in: PubMed
    6. Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe C, Gandy S, Steele JW. Effective anti-Alzheimer Aß therapy involves depletion of specific Aß oligomer subtypes. Neurol Neuroimmunol Neuroinflamm. 2016 Jun; 3(3):e237. PMID: 27218118; PMCID: PMC4864617.
    7. Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathol Commun. 2016 Feb 25; 4:16. PMID: 26916443; PMCID: PMC4766719.
    8. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. Synaptic Amyloid-ß Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol. 2016 Jan; 186(1):185-98. PMID: 26718979; PMCID: PMC4715217 [Available on 01/01/17].
    9. Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-ß Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with a-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016; 50(2):517-25. PMID: 26682688.
      View in: PubMed
    10. Teng E, Taylor K, Bilousova T, Weiland D, Pham T, Zuo X, Yang F, Chen PP, Glabe C, Takacs A, Hoffman DR, Frautschy SA, Cole GM. Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aß pathology and modulates Aß oligomerization. Neurobiol Dis. 2015 Oct; 82:552-560. PMID: 26369878; PMCID: PMC4641021 [Available on 10/01/16].
    11. Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ, Dikalov SI, Glabe C, Amarnath V, Barnett JV, Murray KT. Reactive ?-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. J Mol Cell Cardiol. 2015 Feb; 79:295-302. PMID: 25463275.
      View in: PubMed
    12. Hatami A, Albay R, Monjazeb S, Milton S, Glabe C. Monoclonal antibodies against Aß42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain. J Biol Chem. 2014 Nov 14; 289(46):32131-43. PMID: 25281743; PMCID: PMC4231689.
    13. Pensalfini A, Albay R, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe C. Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Neurobiol Dis. 2014 Nov; 71:53-61. PMID: 25092575; PMCID: PMC4179983.
    14. Rivera JF, Costes S, Gurlo T, Glabe C, Butler PC. Autophagy defends pancreatic ß cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 2014 Aug; 124(8):3489-500. PMID: 25036708; PMCID: PMC4109537.
    15. Buhimschi IA, Nayeri UA, Zhao G, Shook LL, Pensalfini A, Funai EF, Bernstein IM, Glabe C, Buhimschi CS. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Sci Transl Med. 2014 Jul 16; 6(245):245ra92. PMID: 25031267.
      View in: PubMed
    16. Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe C. Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aß deposition and tau pathology in 3xTg-AD mice. J Neurochem. 2013 Aug; 126(4):473-82. PMID: 23672786; PMCID: PMC4105004.
    17. Rasool S, Martinez-Coria H, Milton S, Glabe C. Nonhuman amyloid oligomer epitope reduces Alzheimer's-like neuropathology in 3xTg-AD transgenic mice. Mol Neurobiol. 2013 Dec; 48(3):931-40. PMID: 23771815.
      View in: PubMed
    18. Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe C, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aß, and frank neuronal loss. J Neurosci. 2013 Apr 10; 33(15):6245-56. PMID: 23575824; PMCID: PMC3720142.
    19. McLean D, Cooke MJ, Albay R, Glabe C, Shoichet MS. Positron emission tomography imaging of fibrillar parenchymal and vascular amyloid-ß in TgCRND8 mice. ACS Chem Neurosci. 2013 Apr 17; 4(4):613-23. PMID: 23509918; PMCID: PMC3629748.
    20. Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe C, Potkin SG, Frydman J, Thompson LM. Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3077-82. PMID: 23365139; PMCID: PMC3581981.
    21. Ringman JM, Tomic JL, Coppola G, Elashoff D, Gylys KH, Glabe C. Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):652-7. PMID: 23341831; PMCID: PMC3551434.
    22. Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe C, Nowick J, Eisenberg D. Out-of-register ß-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20913-8. PMID: 23213214; PMCID: PMC3529048.
    23. Arai H, Glabe C, Luecke H. Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers. Biochim Biophys Acta. 2012 Dec; 1820(12):1908-14. PMID: 22940003; PMCID: PMC3973424.
    24. Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM. Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. J Neurosci. 2012 Aug 08; 32(32):11109-19. PMID: 22875942; PMCID: PMC3546821.
    25. Rasool S, Albay R, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe C. Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Mol Neurodegener. 2012 Aug 06; 7:37. PMID: 22866920; PMCID: PMC3476970.
    26. Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe C, Demuth HU, Bloom GS. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-ß. Nature. 2012 May 02; 485(7400):651-5. PMID: 22660329; PMCID: PMC3367389.
    27. Lioudyno MI, Broccio M, Sokolov Y, Rasool S, Wu J, Alkire MT, Liu V, Kozak JA, Dennison PR, Glabe C, Lösche M, Hall JE. Effect of synthetic aß peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One. 2012; 7(4):e35090. PMID: 22563377; PMCID: PMC3338507.
    28. Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 09; 335(6073):1228-31. PMID: 22403391; PMCID: PMC3959867.
    29. Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. Accumulation of toxic a-synuclein oligomer within endoplasmic reticulum occurs in a-synucleinopathy in vivo. J Neurosci. 2012 Mar 07; 32(10):3301-5. PMID: 22399752; PMCID: PMC3548448.
    30. Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe C, Muchowski PJ, Thompson LM. Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules. J Huntingtons Dis. 2012; 1(1):119-32. PMID: 24086178; PMCID: PMC3786168.
    31. Lasagna-Reeves CA, Glabe C, Kayed R. Amyloid-ß annular protofibrils evade fibrillar fate in Alzheimer disease brain. J Biol Chem. 2011 Jun 24; 286(25):22122-30. PMID: 21507938; PMCID: PMC3121356.
    32. Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe C, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J. CD45 deficiency drives amyloid-ß peptide oligomers and neuronal loss in Alzheimer's disease mice. J Neurosci. 2011 Jan 26; 31(4):1355-65. PMID: 21273420; PMCID: PMC3068193.
    33. Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aß oligomers. Mol Neurodegener. 2010 Dec 13; 5:57. PMID: 21144050; PMCID: PMC3019145.
    34. Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Heat-shock protein 70 modulates toxic extracellular a-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J. 2011 Jan; 25(1):326-36. PMID: 20876215; PMCID: PMC3005424.
    35. Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol. 2010 Aug; 68(2):220-30. PMID: 20641005; PMCID: PMC3094694.
    36. Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J. 2010 Jul; 277(14):3051-67. PMID: 20573181; PMCID: PMC2933033.
    37. Pop V, Head E, Berchtold NC, Glabe C, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aß aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. PMID: 20434811; PMCID: PMC2932860.
    38. Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe C, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. J Alzheimers Dis. 2010; 20(2):637-46. PMID: 20164551; PMCID: PMC2903832.
    39. Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe C, Butler PC. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010 Feb; 176(2):861-9. PMID: 20042670; PMCID: PMC2808091.
    40. Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C. Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. J Biol Chem. 2010 Feb 26; 285(9):6071-9. PMID: 20018889; PMCID: PMC2825401.
    41. Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe C, Langen R, Chen J. Soluble and mature amyloid fibrils in drusen deposits. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1304-10. PMID: 19892876; PMCID: PMC2840723.
    42. Liu B, Rasool S, Yang Z, Glabe C, Schreiber SS, Ge J, Tan Z. Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. Am J Pathol. 2009 Nov; 175(5):2099-110. PMID: 19834067; PMCID: PMC2774073.
    43. Kokubo H, Kayed R, Glabe C, Staufenbiel M, Saido TC, Iwata N, Yamaguchi H. Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. Int J Alzheimers Dis. 2009 Jul 14; 2009. PMID: 20798763; PMCID: PMC2925098.
    44. Mina EW, Lasagna-Reeves C, Glabe C, Kayed R. Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. J Mol Biol. 2009 Aug 21; 391(3):577-85. PMID: 19524592.
      View in: PubMed
    45. Tomic JL, Pensalfini A, Head E, Glabe C. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis. 2009 Sep; 35(3):352-8. PMID: 19523517; PMCID: PMC2725199.
    46. Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis. 2009 Oct; 36(1):11-25. PMID: 19497367.
      View in: PubMed
    47. Sanbe A, Daicho T, Mizutani R, Endo T, Miyauchi N, Yamauchi J, Tanonaka K, Glabe C, Tanoue A. Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy. PLoS One. 2009; 4(4):e5351. PMID: 19399179; PMCID: PMC2670514.
    48. Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathol. 2009 Oct; 118(4):505-17. PMID: 19360426; PMCID: PMC2737113.
    49. Deshpande A, Kawai H, Metherate R, Glabe C, Busciglio J. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci. 2009 Apr 01; 29(13):4004-15. PMID: 19339596.
      View in: PubMed
    50. Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem. 2009 Feb 13; 284(7):4230-7. PMID: 19098006; PMCID: PMC2640961.
    51. Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe C, Langen R, Chen J. Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Mol Neurodegener. 2008 Oct 21; 3:16. PMID: 18939994; PMCID: PMC2577670.
    52. Glabe C. Structural classification of toxic amyloid oligomers. J Biol Chem. 2008 Oct 31; 283(44):29639-43. PMID: 18723507; PMCID: PMC2573087.
    53. Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Hoppmann A, Sachser N, Klotsche J, Schnell S, Lewejohann L, Al-Abed Y. CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. J Exp Med. 2008 Jul 07; 205(7):1593-9. PMID: 18573905; PMCID: PMC2442637.
    54. Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe C, Cotman CW. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation. 2008 Apr 09; 5:13. PMID: 18400101; PMCID: PMC2329612.
    55. Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J Neurosci. 2008 Apr 02; 28(14):3555-66. PMID: 18385314.
      View in: PubMed
    56. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe C. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18. PMID: 17897471; PMCID: PMC2100048.
    57. Necula M, Breydo L, Milton S, Kayed R, van der Veer WE, Tone P, Glabe C. Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. Biochemistry. 2007 Jul 31; 46(30):8850-60. PMID: 17595112.
      View in: PubMed
    58. Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe C, Cribbs DH, Agadjanyan MG. Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers. J Biol Chem. 2007 Aug 03; 282(31):22376-86. PMID: 17545160; PMCID: PMC2435219.
    59. Maloyan A, Gulick J, Glabe C, Kayed R, Robbins J. Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5995-6000. PMID: 17389375; PMCID: PMC1851605.
    60. Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe C, Butler PC. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 2007 May; 56(5):1324-32. PMID: 17353506.
      View in: PubMed
    61. Necula M, Kayed R, Milton S, Glabe C. Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct. J Biol Chem. 2007 Apr 06; 282(14):10311-24. PMID: 17284452.
      View in: PubMed
    62. Yoshiike Y, Kayed R, Milton SC, Takashima A, Glabe C. Pore-forming proteins share structural and functional homology with amyloid oligomers. Neuromolecular Med. 2007; 9(3):270-5. PMID: 17914185.
      View in: PubMed
    63. King ME, Kan HM, Baas PW, Erisir A, Glabe C, Bloom GS. Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid. J Cell Biol. 2006 Nov 20; 175(4):541-6. PMID: 17101697; PMCID: PMC2064590.
    64. Sokolov Y, Kozak JA, Kayed R, Chanturiya A, Glabe C, Hall JE. Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J Gen Physiol. 2006 Dec; 128(6):637-47. PMID: 17101816; PMCID: PMC2151594.
    65. Glabe C. Biomedicine. Avoiding collateral damage in Alzheimer's disease treatment. Science. 2006 Oct 27; 314(5799):602-3. PMID: 17068248.
      View in: PubMed
    66. Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe C, Butler PC. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1317-24. PMID: 16849627.
      View in: PubMed
    67. Chen YR, Glabe C. Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42. J Biol Chem. 2006 Aug 25; 281(34):24414-22. PMID: 16809342.
      View in: PubMed
    68. Deshpande A, Mina E, Glabe C, Busciglio J. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci. 2006 May 31; 26(22):6011-8. PMID: 16738244.
      View in: PubMed
    69. Chong YH, Shin YJ, Lee EO, Kayed R, Glabe C, Tenner AJ. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem. 2006 Jul 21; 281(29):20315-25. PMID: 16714296.
      View in: PubMed
    70. Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe C, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006 Mar 16; 440(7082):352-7. PMID: 16541076.
      View in: PubMed
    71. Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe C, Teter B, Frautschy SA, Cole GM. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res. 2006 Feb 15; 83(3):374-84. PMID: 16385556.
      View in: PubMed
    72. Glabe C. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging. 2006 Apr; 27(4):570-5. PMID: 16481071.
      View in: PubMed
    73. Luibl V, Isas JM, Kayed R, Glabe C, Langen R, Chen J. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest. 2006 Feb; 116(2):378-85. PMID: 16453022; PMCID: PMC1359048.
    74. Glabe C, Kayed R. Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology. 2006 Jan 24; 66(2 Suppl 1):S74-8. PMID: 16432151.
      View in: PubMed
    75. Kayed R, Glabe C. Conformation-dependent anti-amyloid oligomer antibodies. Methods Enzymol. 2006; 413:326-44. PMID: 17046404.
      View in: PubMed
    76. Zhou J, Fonseca MI, Kayed R, Hernandez I, Webster SD, Yazan O, Cribbs DH, Glabe C, Tenner AJ. Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. J Neuroinflammation. 2005 Dec 07; 2:28. PMID: 16332263; PMCID: PMC1326209.
    77. Oddo S, Caccamo A, Tran L, Lambert MP, Glabe C, Klein WL, LaFerla FM. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem. 2006 Jan 20; 281(3):1599-604. PMID: 16282321.
      View in: PubMed
    78. Lesné S, Ali C, Gabriel C, Croci N, MacKenzie ET, Glabe C, Plotkine M, Marchand-Verrecchia C, Vivien D, Buisson A. NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci. 2005 Oct 12; 25(41):9367-77. PMID: 16221845.
      View in: PubMed
    79. Sanbe A, Osinska H, Villa C, Gulick J, Klevitsky R, Glabe C, Kayed R, Robbins J. Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13592-7. PMID: 16155124; PMCID: PMC1224623.
    80. Kokubo H, Kayed R, Glabe C, Saido TC, Iwata N, Helms JB, Yamaguchi H. Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Res. 2005 May 31; 1045(1-2):224-8. PMID: 15910781.
      View in: PubMed
    81. Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe C. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem. 2005 Apr 29; 280(17):17294-300. PMID: 15722360.
      View in: PubMed
    82. Kokubo H, Kayed R, Glabe C, Yamaguchi H. Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Res. 2005 Jan 21; 1031(2):222-8. PMID: 15649447.
      View in: PubMed
    83. Bloom GS, Ren K, Glabe C. Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid. Biochim Biophys Acta. 2005 Jan 03; 1739(2-3):116-24. PMID: 15615631.
      View in: PubMed
    84. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe C, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18; 280(7):5892-901. PMID: 15590663.
      View in: PubMed
    85. Glabe C. Conformation-dependent antibodies target diseases of protein misfolding. Trends Biochem Sci. 2004 Oct; 29(10):542-7. PMID: 15450609.
      View in: PubMed
    86. Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe C. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem. 2004 Nov 05; 279(45):46363-6. PMID: 15385542.
      View in: PubMed
    87. Sanbe A, Osinska H, Saffitz JE, Glabe C, Kayed R, Maloyan A, Robbins J. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10132-6. PMID: 15220483; PMCID: PMC454177.
    88. Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe C, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4752-7. PMID: 15034169; PMCID: PMC387320.
    89. Kamei N, Glabe C. The species-specific egg receptor for sea urchin sperm adhesion is EBR1,a novel ADAMTS protein. Genes Dev. 2003 Oct 15; 17(20):2502-7. PMID: 14561772; PMCID: PMC218143.
    90. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe C. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. PMID: 12702875.
      View in: PubMed
    91. Yoburn JC, Tian W, Brower JO, Nowick JS, Glabe C, Van Vranken DL. Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structure. Chem Res Toxicol. 2003 Apr; 16(4):531-5. PMID: 12703970.
      View in: PubMed
    92. Török M, Milton S, Kayed R, Wu P, McIntire T, Glabe C, Langen R. Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling. J Biol Chem. 2002 Oct 25; 277(43):40810-5. PMID: 12181315.
      View in: PubMed
    93. Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe C. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med. 2002; 1(1):81-94. PMID: 12025818.
      View in: PubMed
    94. Glabe C. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease. J Mol Neurosci. 2001 Oct; 17(2):137-45. PMID: 11816787.
      View in: PubMed
    Charles's Networks
    Derived automatically from this person's publications.
    People in Profiles who have published with this person.
    Related Authors
    People who share related concepts with this person.