Charles Glabe

Title(s)Professor, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address3228 McGaugh Hall
Zot 3900
Irvine CA 92697
Phone(949) 824-6081, 4229
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    Collapse Research 
    Collapse Research Activities and Funding
    Endogenous human antibodies in aging and Alzheimer's disease and the immune response to amyloid
    NIH RF1AG061857Sep 30, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH/NIA R01AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    Age-related metabolic alterations in amyloid processing in Alzheimer's disease
    NIH RF1AG058218Jul 15, 2018 - Mar 31, 2023
    Role: Co-Principal Investigator
    Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics
    NIH RF1AG056507Jul 1, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics
    NIH/NIA R01AG056507Jul 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    Conformational polymorphisms of amyloid in AD and immunological biomarkers and therapeutics
    NIH R56AG056507Sep 15, 2017 - Jun 30, 2018
    Role: Principal Investigator
    Novel nuclear and intracellular pathology in early AD
    NIH R21AG045729May 1, 2014 - Apr 30, 2016
    Role: Principal Investigator
    Structure and conformational diversity of amyloid oligomers
    NIH R01AG033069Apr 1, 2010 - Mar 31, 2015
    Role: Principal Investigator
    DEGRADATION OF THE TRANSMEMBRANE DOMAIN OF APP
    NIH R01NS038298Dec 1, 1998 - Nov 30, 2004
    Role: Principal Investigator
    Structure of Amyloid A Beta &Fibril Assembly Dynamics
    NIH R01NS031230Sep 1, 1993 - Feb 28, 2008
    Role: Principal Investigator
    STRUCTURE, ORGANIZATION, AND FUNCTION OF BINDIN
    NIH R01HD021379Jan 1, 1983 - Dec 31, 1999
    Role: Principal Investigator
    STRUCTURE, ORGANIZATION AND FUNCTION OF BINDIN
    NIH R01HD017396Jan 1, 1983 - Jun 30, 1985
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2300258120. Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS. PMID: 37801475; PMCID: PMC10576031.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    2. Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease. Alzheimers Dement. 2023 06; 19(6):2239-2252. Castranio EL, Hasel P, Haure-Mirande JV, Ramirez Jimenez AV, Hamilton BW, Kim RD, Glabe CG, Wang M, Zhang B, Gandy S, Liddelow SA, Ehrlich ME. PMID: 36448627; PMCID: PMC10481344.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    3. Intracellular Injection of Brain Extracts from Alzheimer's Disease Patients Triggers Unregulated Ca2+ Release from Intracellular Stores That Hinders Cellular Bioenergetics. Cells. 2022 Nov 16; 11(22). Pensalfini A, Umar AR, Glabe C, Parker I, Ullah G, Demuro A. PMID: 36429057.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Conformation-dependent anti-Aβ monoclonal antibody signatures of disease status and severity in urine of women with preeclampsia. Pregnancy Hypertens. 2022 Jun; 28:51-59. Valtanen RS, Buhimschi CS, Bahtiyar MO, Zhao G, Jing H, Ackerman WE, Glabe CG, Buhimschi IA. PMID: 35183929; PMCID: PMC9133023.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model. J Alzheimers Dis. 2022; 90(4):1501-1521. Pontrello CG, McWhirt JM, Glabe CG, Brewer GJ. PMID: 36278355; PMCID: PMC9789488.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Acta Neuropathol Commun. 2021 10 18; 9(1):169. Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, Huh S, Vogel H, Glabe C, Grinberg LT, Spina S, Seeley WW, Guo S, Lu B. PMID: 34663454; PMCID: PMC8522249.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    7. An "epitomic" analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies. J Biol Chem. 2021 Jan-Jun; 296:100168. Reyes-Ruiz JM, Nakajima R, Baghallab I, Goldschmidt L, Sosna J, Mai Ho PN, Kumosani T, Felgner PL, Glabe C. PMID: 33298522; PMCID: PMC7949048.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. Identification of amyloid antibodies for Alzheimer disease - immunotherapy. Arch Physiol Biochem. 2022 Oct; 128(5):1275-1282. Huwait EA, Baghallab IM, Glabe CG, Abulnaja KO, Kumosani TA, Moselhy SS. PMID: 32449861.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. In vitro study of the mechanism of intraneuronal β-amyloid aggregation in Alzheimer's disease. Arch Physiol Biochem. 2022 Jun; 128(3):732-739. Alsunusi S, Kumosani TA, Glabe CG, Huwait EA, Moselhy SS. PMID: 32046518.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    10. Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes. J Alzheimers Dis. 2020; 73(1):229-246. Brewer GJ, Herrera RA, Philipp S, Sosna J, Reyes-Ruiz JM, Glabe CG. PMID: 31771065; PMCID: PMC7029321.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Sci Rep. 2019 11 04; 9(1):15936. Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, Medeiros R, Kitazawa M, Glabe CG, Cotman CW, Golde T, Baglietto-Vargas D, LaFerla FM. PMID: 31685865; PMCID: PMC6828807.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. Elife. 2019 10 15; 8. Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. PMID: 31612856; PMCID: PMC6850776.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    13. Apolipoprotein E/Amyloid-β Complex Accumulates in Alzheimer Disease Cortical Synapses via Apolipoprotein E Receptors and Is Enhanced by APOE4. Am J Pathol. 2019 08; 189(8):1621-1636. Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas C, Hatami A, Albay R, Glabe C, Gylys KH. PMID: 31108099; PMCID: PMC6680253.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    14. Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Mol Neurodegener. 2018 03 01; 13(1):11. Sosna J, Philipp S, Albay R, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. PMID: 29490706; PMCID: PMC5831225.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    15. Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart Failure. Circ Res. 2018 05 11; 122(10):e75-e83. Rainer PP, Dong P, Sorge M, Fert-Bober J, Holewinski RJ, Wang Y, Foss CA, An SS, Baracca A, Solaini G, Glabe CG, Pomper MG, Van Eyk JE, Tomaselli GF, Paolocci N, Agnetti G. PMID: 29483093; PMCID: PMC5948147.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    16. Epitomic Characterization of the Specificity of the Anti-Amyloid Aβ Monoclonal Antibodies 6E10 and 4G8. J Alzheimers Dis. 2018; 66(3):1235-1244. Baghallab I, Reyes-Ruiz JM, Abulnaja K, Huwait E, Glabe C. PMID: 30412489; PMCID: PMC6294585.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    17. Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. PMID: 29282295; PMCID: PMC5827424.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    18. Familial Alzheimer's Disease Mutations within the Amyloid Precursor Protein Alter the Aggregation and Conformation of the Amyloid-β Peptide. J Biol Chem. 2017 02 24; 292(8):3172-3185. Hatami A, Monjazeb S, Milton S, Glabe CG. PMID: 28049728; PMCID: PMC5336154.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    19. Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):E4976-84. Wälti MA, Ravotti F, Arai H, Glabe CG, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R. PMID: 27469165; PMCID: PMC5003276.
      View in: PubMed   Mentions: 344     Fields:    Translation:HumansCells
    20. Structural differences between amyloid beta oligomers. Biochem Biophys Res Commun. 2016 09 02; 477(4):700-705. Breydo L, Kurouski D, Rasool S, Milton S, Wu JW, Uversky VN, Lednev IK, Glabe CG. PMID: 27363332.
      View in: PubMed   Mentions: 31     Fields:    Translation:Cells
    21. Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes. Neurol Neuroimmunol Neuroinflamm. 2016 Jun; 3(3):e237. Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW. PMID: 27218118; PMCID: PMC4864617.
      View in: PubMed   Mentions: 25     Fields:    
    22. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathol Commun. 2016 Feb 25; 4:16. Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. PMID: 26916443; PMCID: PMC4766719.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    23. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. J Alzheimers Dis. 2016; 50(2):517-25. Hatami A, Monjazeb S, Glabe C. PMID: 26682688.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    24. Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. Am J Pathol. 2016 Jan; 186(1):185-98. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. PMID: 26718979; PMCID: PMC4715217.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    25. Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization. Neurobiol Dis. 2015 Oct; 82:552-560. Teng E, Taylor K, Bilousova T, Weiland D, Pham T, Zuo X, Yang F, Chen PP, Glabe CG, Takacs A, Hoffman DR, Frautschy SA, Cole GM. PMID: 26369878; PMCID: PMC4641021.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    26. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Mol Psychiatry. 2015 Nov; 20(11):1286-93. Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG. PMID: 26100538; PMCID: PMC4718563.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    27. Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells. J Mol Cell Cardiol. 2015 Feb; 79:295-302. Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT. PMID: 25463275; PMCID: PMC4302000.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    28. Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain. J Biol Chem. 2014 Nov 14; 289(46):32131-32143. Hatami A, Albay R, Monjazeb S, Milton S, Glabe C. PMID: 25281743; PMCID: PMC4231689.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    29. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov; 19(11):1235-42. Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. PMID: 25113378; PMCID: PMC4217144.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    30. Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Neurobiol Dis. 2014 Nov; 71:53-61. Pensalfini A, Albay R, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. PMID: 25092575; PMCID: PMC4179983.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    31. Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity. J Clin Invest. 2014 Aug; 124(8):3489-500. Rivera JF, Costes S, Gurlo T, Glabe CG, Butler PC. PMID: 25036708; PMCID: PMC4109537.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    32. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Sci Transl Med. 2014 Jul 16; 6(245):245ra92. Buhimschi IA, Nayeri UA, Zhao G, Shook LL, Pensalfini A, Funai EF, Bernstein IM, Glabe CG, Buhimschi CS. PMID: 25031267.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansCells
    33. Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice. J Neurochem. 2013 Aug; 126(4):473-82. Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG. PMID: 23672786; PMCID: PMC4105004.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCellsPHPublic Health
    34. Nonhuman amyloid oligomer epitope reduces Alzheimer's-like neuropathology in 3xTg-AD transgenic mice. Mol Neurobiol. 2013 Dec; 48(3):931-40. Rasool S, Martinez-Coria H, Milton S, Glabe CG. PMID: 23771815.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    35. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. J Neurosci. 2013 Apr 10; 33(15):6245-56. Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T. PMID: 23575824; PMCID: PMC3720142.
      View in: PubMed   Mentions: 198     Fields:    Translation:HumansAnimals
    36. Positron emission tomography imaging of fibrillar parenchymal and vascular amyloid-β in TgCRND8 mice. ACS Chem Neurosci. 2013 Apr 17; 4(4):613-23. McLean D, Cooke MJ, Albay R, Glabe C, Shoichet MS. PMID: 23509918; PMCID: PMC3629748.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    37. Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3077-82. Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM. PMID: 23365139; PMCID: PMC3581981.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    38. Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):652-7. Ringman JM, Tomic JL, Coppola G, Elashoff D, Gylys KH, Glabe CG. PMID: 23341831; PMCID: PMC3551434.
      View in: PubMed   Mentions: 4  
    39. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20913-8. Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. PMID: 23213214; PMCID: PMC3529048.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    40. Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation. Transl Psychiatry. 2012 Nov 13; 2:e183. Kulic L, McAfoose J, Welt T, Tackenberg C, Späni C, Wirth F, Finder V, Konietzko U, Giese M, Eckert A, Noriaki K, Shimizu T, Murakami K, Irie K, Rasool S, Glabe C, Hock C, Nitsch RM. PMID: 23149447; PMCID: PMC3565767.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    41. Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers. Biochim Biophys Acta. 2012 Dec; 1820(12):1908-14. Arai H, Glabe C, Luecke H. PMID: 22940003; PMCID: PMC3973424.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    42. Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. J Neurosci. 2012 Aug 08; 32(32):11109-19. Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM. PMID: 22875942; PMCID: PMC3546821.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    43. Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Mol Neurodegener. 2012 Aug 06; 7:37. Rasool S, Albay R, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. PMID: 22866920; PMCID: PMC3476970.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    44. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Mol Psychiatry. 2013 Aug; 18(8):889-97. Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. PMID: 22850627; PMCID: PMC3625697.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    45. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature. 2012 May 02; 485(7400):651-5. Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU, Bloom GS. PMID: 22660329; PMCID: PMC3367389.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansAnimals
    46. Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One. 2012; 7(4):e35090. Lioudyno MI, Broccio M, Sokolov Y, Rasool S, Wu J, Alkire MT, Liu V, Kozak JA, Dennison PR, Glabe CG, Lösche M, Hall JE. PMID: 22563377; PMCID: PMC3338507.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    47. Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 09; 335(6073):1228-31. Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. PMID: 22403391; PMCID: PMC3959867.
      View in: PubMed   Mentions: 260     Fields:    Translation:Cells
    48. Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J Neurosci. 2012 Mar 07; 32(10):3301-5. Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. PMID: 22399752; PMCID: PMC3548448.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    49. Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules. J Huntingtons Dis. 2012; 1(1):119-32. Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe CG, Muchowski PJ, Thompson LM. PMID: 24086178; PMCID: PMC3786168.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    50. Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain. J Biol Chem. 2011 Jun 24; 286(25):22122-30. Lasagna-Reeves CA, Glabe CG, Kayed R. PMID: 21507938; PMCID: PMC3121356.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    51. Transgenic mice as a model of pre-clinical Alzheimer's disease. Curr Alzheimer Res. 2011 Feb; 8(1):4-23. Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC. PMID: 21143159.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    52. CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice. J Neurosci. 2011 Jan 26; 31(4):1355-65. Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J. PMID: 21273420; PMCID: PMC3068193.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    53. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Mol Neurodegener. 2010 Dec 13; 5:57. Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. PMID: 21144050; PMCID: PMC3019145.
      View in: PubMed   Mentions: 80     Fields:    
    54. Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. FASEB J. 2011 Jan; 25(1):326-36. Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. PMID: 20876215; PMCID: PMC3005424.
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    55. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol. 2010 Aug; 68(2):220-30. Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. PMID: 20641005; PMCID: PMC3094694.
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    56. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J. 2010 Jul; 277(14):3051-67. Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. PMID: 20573181; PMCID: PMC2933033.
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    57. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiol Aging. 2012 Jan; 33(1):108-20. Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. PMID: 20434811; PMCID: PMC2932860.
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    58. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. J Alzheimers Dis. 2010; 20(2):637-46. Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. PMID: 20164551; PMCID: PMC2903832.
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    59. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. Am J Pathol. 2010 Feb; 176(2):861-9. Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC. PMID: 20042670; PMCID: PMC2808091.
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    60. Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. J Biol Chem. 2010 Feb 26; 285(9):6071-9. Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C. PMID: 20018889; PMCID: PMC2825401.
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    61. Soluble and mature amyloid fibrils in drusen deposits. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1304-10. Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J. PMID: 19892876; PMCID: PMC2840723.
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    62. Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. Am J Pathol. 2009 Nov; 175(5):2099-110. Liu B, Rasool S, Yang Z, Glabe CG, Schreiber SS, Ge J, Tan Z. PMID: 19834067; PMCID: PMC2774073.
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    63. Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. Int J Alzheimers Dis. 2009 Jul 14; 2009. Kokubo H, Kayed R, Glabe CG, Staufenbiel M, Saido TC, Iwata N, Yamaguchi H. PMID: 20798763; PMCID: PMC2925098.
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    64. Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. J Mol Biol. 2009 Aug 21; 391(3):577-85. Mina EW, Lasagna-Reeves C, Glabe CG, Kayed R. PMID: 19524592.
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    65. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis. 2009 Sep; 35(3):352-8. Tomic JL, Pensalfini A, Head E, Glabe CG. PMID: 19523517; PMCID: PMC2725199.
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    66. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiol Dis. 2009 Oct; 36(1):11-25. Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS. PMID: 19497367.
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    67. Protective effect of geranylgeranylacetone via enhancement of HSPB8 induction in desmin-related cardiomyopathy. PLoS One. 2009; 4(4):e5351. Sanbe A, Daicho T, Mizutani R, Endo T, Miyauchi N, Yamauchi J, Tanonaka K, Glabe C, Tanoue A. PMID: 19399179; PMCID: PMC2670514.
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    68. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathol. 2009 Oct; 118(4):505-17. Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. PMID: 19360426; PMCID: PMC2737113.
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    69. A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses. J Neurosci. 2009 Apr 01; 29(13):4004-15. Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J. PMID: 19339596; PMCID: PMC6665357.
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    70. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. J Biol Chem. 2009 Feb 13; 284(7):4230-7. Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. PMID: 19098006; PMCID: PMC2640961.
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    71. Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Mol Neurodegener. 2008 Oct 21; 3:16. Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J. PMID: 18939994; PMCID: PMC2577670.
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    72. Structural classification of toxic amyloid oligomers. J Biol Chem. 2008 Oct 31; 283(44):29639-43. Glabe CG. PMID: 18723507; PMCID: PMC2573087.
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    73. CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. J Exp Med. 2008 Jul 07; 205(7):1593-9. Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Hoppmann A, Sachser N, Klotsche J, Schnell S, Lewejohann L, Al-Abed Y. PMID: 18573905; PMCID: PMC2442637.
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    74. Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid. J Neuroinflammation. 2008 Apr 09; 5:13. Nichol KE, Poon WW, Parachikova AI, Cribbs DH, Glabe CG, Cotman CW. PMID: 18400101; PMCID: PMC2329612.
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    75. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J Neurosci. 2008 Apr 02; 28(14):3555-66. Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. PMID: 18385314; PMCID: PMC6671080.
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    76. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener. 2007 Sep 26; 2:18. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. PMID: 17897471; PMCID: PMC2100048.
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    77. Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. Biochemistry. 2007 Jul 31; 46(30):8850-60. Necula M, Breydo L, Milton S, Kayed R, van der Veer WE, Tone P, Glabe CG. PMID: 17595112.
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    78. Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers. J Biol Chem. 2007 Aug 03; 282(31):22376-86. Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG. PMID: 17545160; PMCID: PMC2435219.
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    79. Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2007 Apr 03; 104(14):5995-6000. Maloyan A, Gulick J, Glabe CG, Kayed R, Robbins J. PMID: 17389375; PMCID: PMC1851605.
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    80. Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice. Diabetes. 2007 May; 56(5):1324-32. Lin CY, Gurlo T, Kayed R, Butler AE, Haataja L, Glabe CG, Butler PC. PMID: 17353506.
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    81. Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct. J Biol Chem. 2007 Apr 06; 282(14):10311-24. Necula M, Kayed R, Milton S, Glabe CG. PMID: 17284452.
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    82. Pore-forming proteins share structural and functional homology with amyloid oligomers. Neuromolecular Med. 2007; 9(3):270-5. Yoshiike Y, Kayed R, Milton SC, Takashima A, Glabe CG. PMID: 17914185.
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    83. Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid. J Cell Biol. 2006 Nov 20; 175(4):541-6. King ME, Kan HM, Baas PW, Erisir A, Glabe CG, Bloom GS. PMID: 17101697; PMCID: PMC2064590.
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    84. Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J Gen Physiol. 2006 Dec; 128(6):637-47. Sokolov Y, Kozak JA, Kayed R, Chanturiya A, Glabe C, Hall JE. PMID: 17101816; PMCID: PMC2151594.
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    85. Biomedicine. Avoiding collateral damage in Alzheimer's disease treatment. Science. 2006 Oct 27; 314(5799):602-3. Glabe C. PMID: 17068248.
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    86. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1317-24. Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. PMID: 16849627.
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    87. Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42. J Biol Chem. 2006 Aug 25; 281(34):24414-22. Chen YR, Glabe CG. PMID: 16809342.
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    88. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci. 2006 May 31; 26(22):6011-8. Deshpande A, Mina E, Glabe C, Busciglio J. PMID: 16738244; PMCID: PMC6675207.
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    89. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J Biol Chem. 2006 Jul 21; 281(29):20315-25. Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ. PMID: 16714296.
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    90. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 2006 Mar 16; 440(7082):352-7. Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. PMID: 16541076.
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    91. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. J Neurosci Res. 2006 Feb 15; 83(3):374-84. Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. PMID: 16385556.
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    92. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease. Neurobiol Aging. 2006 Apr; 27(4):570-5. Glabe CG. PMID: 16481071.
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    93. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. J Clin Invest. 2006 Feb; 116(2):378-85. Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J. PMID: 16453022; PMCID: PMC1359048.
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    94. Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology. 2006 Jan 24; 66(2 Suppl 1):S74-8. Glabe CG, Kayed R. PMID: 16432151.
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    95. Conformation-dependent anti-amyloid oligomer antibodies. Methods Enzymol. 2006; 413:326-44. Kayed R, Glabe CG. PMID: 17046404.
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    96. Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. J Neuroinflammation. 2005 Dec 07; 2:28. Zhou J, Fonseca MI, Kayed R, Hernandez I, Webster SD, Yazan O, Cribbs DH, Glabe CG, Tenner AJ. PMID: 16332263; PMCID: PMC1326209.
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    97. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem. 2006 Jan 20; 281(3):1599-604. Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. PMID: 16282321.
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    98. NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci. 2005 Oct 12; 25(41):9367-77. Lesné S, Ali C, Gabriel C, Croci N, MacKenzie ET, Glabe CG, Plotkine M, Marchand-Verrecchia C, Vivien D, Buisson A. PMID: 16221845; PMCID: PMC6725703.
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    99. Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13592-7. Sanbe A, Osinska H, Villa C, Gulick J, Klevitsky R, Glabe CG, Kayed R, Robbins J. PMID: 16155124; PMCID: PMC1224623.
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    100. Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Res. 2005 May 31; 1045(1-2):224-8. Kokubo H, Kayed R, Glabe CG, Saido TC, Iwata N, Helms JB, Yamaguchi H. PMID: 15910781.
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    101. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem. 2005 Apr 29; 280(17):17294-300. Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. PMID: 15722360.
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    102. Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Res. 2005 Jan 21; 1031(2):222-8. Kokubo H, Kayed R, Glabe CG, Yamaguchi H. PMID: 15649447.
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    103. Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid. Biochim Biophys Acta. 2005 Jan 03; 1739(2-3):116-24. Bloom GS, Ren K, Glabe CG. PMID: 15615631.
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    104. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18; 280(7):5892-901. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. PMID: 15590663.
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    105. Conformation-dependent antibodies target diseases of protein misfolding. Trends Biochem Sci. 2004 Oct; 29(10):542-7. Glabe CG. PMID: 15450609.
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    106. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J Biol Chem. 2004 Nov 05; 279(45):46363-6. Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe CG. PMID: 15385542.
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    107. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10132-6. Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. PMID: 15220483; PMCID: PMC454177.
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    108. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4752-7. Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. PMID: 15034169; PMCID: PMC387320.
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    109. The species-specific egg receptor for sea urchin sperm adhesion is EBR1,a novel ADAMTS protein. Genes Dev. 2003 Oct 15; 17(20):2502-7. Kamei N, Glabe CG. PMID: 14561772; PMCID: PMC218143.
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    110. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science. 2003 Apr 18; 300(5618):486-9. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. PMID: 12702875.
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    111. Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structure. Chem Res Toxicol. 2003 Apr; 16(4):531-5. Yoburn JC, Tian W, Brower JO, Nowick JS, Glabe CG, Van Vranken DL. PMID: 12703970.
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    112. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med. 2002; 1(1):81-94. Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. PMID: 12025818.
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    113. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease. J Mol Neurosci. 2001 Oct; 17(2):137-45. Glabe C. PMID: 11816787.
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    114. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiol Dis. 2001 Oct; 8(5):792-806. Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. PMID: 11592849.
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    115. A rapidly diverging EGF protein regulates species-specific signal transduction in early sea urchin development. Dev Biol. 2000 Sep 15; 225(2):267-76. Kamei N, Swanson WJ, Glabe CG. PMID: 10985849.
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    116. A conformation change in the carboxyl terminus of Alzheimer's Abeta (1-40) accompanies the transition from dimer to fibril as revealed by fluorescence quenching analysis. J Biol Chem. 2000 Jul 28; 275(30):22645-9. Garzon-Rodriguez W, Vega A, Sepulveda-Becerra M, Milton S, Johnson DA, Yatsimirsky AK, Glabe CG. PMID: 10806193.
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    117. Does Alzheimer disease tilt the scales of amyloid degradation versus accumulation? Nat Med. 2000 Feb; 6(2):133-4. Glabe C. PMID: 10655093.
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    118. Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp Neurol. 2000 Jan; 161(1):127-38. Webster SD, Yang AJ, Margol L, Garzon-Rodriguez W, Glabe CG, Tenner AJ. PMID: 10683279.
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    119. Subtractive analysis of S. franciscanus and S. purpuratus ovary mRNA: what kinds of genes determine species-specificity? Zygote. 2000; 8 Suppl 1:S64. Kamei N, Glabe CG. PMID: 11191318.
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    120. Toxicity of pyroglutaminated amyloid beta-peptides 3(pE)-40 and -42 is similar to that of A beta1-40 and -42. J Neurochem. 1999 Oct; 73(4):1584-9. Tekirian TL, Yang AY, Glabe C, Geddes JW. PMID: 10501204.
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    121. Binding of Zn(II), Cu(II), and Fe(II) ions to Alzheimer's A beta peptide studied by fluorescence. Bioorg Med Chem Lett. 1999 Aug 02; 9(15):2243-8. Garzon-Rodriguez W, Yatsimirsky AK, Glabe CG. PMID: 10465554.
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    122. Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42. J Biol Chem. 1999 Jul 16; 274(29):20650-6. Yang AJ, Chandswangbhuvana D, Shu T, Henschen A, Glabe CG. PMID: 10400697.
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    123. gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein. J Biol Chem. 1998 Nov 27; 273(48):31947-55. Bunnell WL, Pham HV, Glabe CG. PMID: 9822665.
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    124. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis. J Neurosci Res. 1998 Jun 15; 52(6):691-8. Yang AJ, Chandswangbhuvana D, Margol L, Glabe CG. PMID: 9669318.
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    125. Acceleration of amyloid fibril formation by specific binding of Abeta-(1-40) peptide to ganglioside-containing membrane vesicles. J Biol Chem. 1997 Sep 12; 272(37):22987-90. Choo-Smith LP, Garzon-Rodriguez W, Glabe CG, Surewicz WK. PMID: 9287293.
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    126. Soluble amyloid Abeta-(1-40) exists as a stable dimer at low concentrations. J Biol Chem. 1997 Aug 22; 272(34):21037-44. Garzon-Rodriguez W, Sepulveda-Becerra M, Milton S, Glabe CG. PMID: 9261105.
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    127. Identification of a 97-kDa heat shock protein from S. franciscanus ovaries with 94% amino acid identity to the S. purpuratus egg surface receptor for sperm. Dev Biol. 1997 Apr 01; 184(1):31-7. Mauk R, Jaworski D, Kamei N, Glabe CG. PMID: 9142981.
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    128. Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells. Brain Res. 1997 Jan 23; 746(1-2):275-84. Burdick D, Kosmoski J, Knauer MF, Glabe CG. PMID: 9037507.
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    129. Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques. Exp Neurol. 1997 Jan; 143(1):37-44. Weber LL, Leissring MA, Yang AJ, Glabe CG, Cribbs DH, LaFerla FM. PMID: 9000444.
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    130. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). Brain Res. 1996 Nov 18; 740(1-2):6-14. Knauer MF, Orlando RA, Glabe CG. PMID: 8973792.
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    131. A sparse matrix screen to establish initial conditions for protein renaturation. Anal Biochem. 1995 Sep 01; 230(1):8-15. Hofmann A, Tai M, Wong W, Glabe CG. PMID: 8585634.
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    132. Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia. Exp Neurol. 1995 Aug; 134(2):214-21. Korotzer AR, Watt J, Cribbs D, Tenner AJ, Burdick D, Glabe C, Cotman CW. PMID: 7556541.
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    133. Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells. J Biol Chem. 1995 Jun 16; 270(24):14786-92. Yang AJ, Knauer M, Burdick DA, Glabe C. PMID: 7782344.
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    134. Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. J Neurochem. 1995 Jan; 64(1):253-65. Pike CJ, Walencewicz-Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG, Cotman CW. PMID: 7798921.
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    135. Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation. J Biol Chem. 1994 Nov 18; 269(46):28551-4. Soreghan B, Kosmoski J, Glabe C. PMID: 7961799.
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    136. beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. J Immunol. 1994 May 15; 152(10):5050-9. Jiang H, Burdick D, Glabe CG, Cotman CW, Tenner AJ. PMID: 8176223.
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    137. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci. 1993 Apr; 13(4):1676-87. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. PMID: 8463843; PMCID: PMC6576726.
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    138. Structure/function analysis of the sea urchin sperm adhesive protein bindin. Dev Biol. 1993 Mar; 156(1):24-33. Lopez A, Miraglia SJ, Glabe CG. PMID: 8449368.
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    139. Characterization of the membrane-associating domain of the sperm adhesive protein, bindin. Biochim Biophys Acta. 1993 Feb 09; 1145(2):191-8. Miraglia SJ, Glabe CG. PMID: 8431451.
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    140. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7437-41. Knauer MF, Soreghan B, Burdick D, Kosmoski J, Glabe CG. PMID: 1502155; PMCID: PMC49725.
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    141. Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem. 1992 Jan 05; 267(1):546-54. Burdick D, Soreghan B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C. PMID: 1730616.
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    142. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res. 1991 Nov 01; 563(1-2):311-4. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. PMID: 1786545.
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    143. Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur J Pharmacol. 1991 Aug 14; 207(4):367-8. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. PMID: 1783006.
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    144. The sequence of the Arbacia punctulata bindin cDNA and implications for the structural basis of species-specific sperm adhesion and fertilization. Dev Biol. 1991 Feb; 143(2):282-8. Glabe CG, Clark D. PMID: 1991551.
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    145. Chemical synthesis of biologically active tat trans-activating protein of human immunodeficiency virus type 1. J Virol. 1990 Jun; 64(6):3074-7. Chun R, Glabe CG, Fan H. PMID: 2186178; PMCID: PMC249495.
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    146. Beta-amyloid protein promotes neuritic branching in hippocampal cultures. Neurosci Lett. 1990 Mar 14; 110(3):319-24. Whitson JS, Glabe CG, Shintani E, Abcar A, Cotman CW. PMID: 2183090.
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    147. Zinc specifically stimulates the selective binding of a peptide analog of bindin to sulfated fucans. Pept Res. 1990 Mar-Apr; 3(2):62-8. DeAngelis PL, Glabe CG. PMID: 2134050.
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    148. Specific recognition of sulfate esters by bindin, a sperm adhesion protein from sea urchins. Biochim Biophys Acta. 1990 Jan 19; 1037(1):100-5. DeAngelis PL, Glabe CG. PMID: 2294967.
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    149. Analysis of the membrane-interacting domain of the sea urchin sperm adhesive protein bindin. Biochemistry. 1989 Nov 14; 28(23):9153-8. Kennedy L, DeAngelis PL, Glabe CG. PMID: 2605249.
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    150. Role of basic amino acids in the interaction of bindin with sulfated fucans. Biochemistry. 1988 Oct 18; 27(21):8189-94. DeAngelis PL, Glabe CG. PMID: 3233203.
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    151. Polysaccharide structural features that are critical for the binding of sulfated fucans to bindin, the adhesive protein from sea urchin sperm. J Biol Chem. 1987 Oct 15; 262(29):13946-52. DeAngelis PL, Glabe CG. PMID: 3654649.
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