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Linskey, Mark E

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentSurgery
Address1001 Health Sciences Road
CA 92697-3950
Phone(714) 456-2819
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Trinh AL, Chen H, Chen Y, Hu Y, Li Z, Siegel ER, Linskey M, Wang PH, Digman MA, Zhou YH. Tracking Functional Tumor Cell Subpopulations of Malignant Glioma by Phasor Fluorescence Lifetime Imaging Microscopy of NADH. Cancers (Basel). 2017 Dec 06; 9(12). PMID: 29211022.
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    2. Li Y, Hu Y, Liu C, Wang Q, Han X, Han Y, Xie XS, Chen XH, Li X, Siegel ER, Afrasiabi K, Linskey M, Zhou YX, Zhou YH. Human fibulin-3 protein variant expresses anti-cancer effects in the malignant glioma extracellular compartment in intracranial xenograft models. Oncotarget. 2017 Dec 05; 8(63):106311-106323. PMID: 29290950.
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    3. Zhou YH, Chen Y, Hu Y, Yu L, Tran K, Giedzinski E, Ru N, Gau A, Pan F, Qiao J, Atkin N, Ly KC, Lee N, Siegel ER, Linskey M, Wang P, Limoli C. The role of EGFR double minutes in modulating the response of malignant gliomas to radiotherapy. Oncotarget. 2017 Oct 06; 8(46):80853-80868. PMID: 29113349.
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    4. Zaidi HA, Tumialán LM, Rosenow JM, Colen CB, Stroink AR, Linskey M, Schirmer CM, Watridge C. A History of the Council of State Neurosurgical Societies. Neurosurgery. 2017 01 01; 80(1):146-157. PMID: 28362890.
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    5. Zakrzewska JM, Linskey M. Trigeminal Neuralgia. Am Fam Physician. 2016 Jul 15; 94(2):133-5. PMID: 27419329.
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    6. Zhou YH, Hu Y, Yu L, Ke C, Vo C, Hsu H, Li Z, Di Donato AT, Chaturbedi A, Hwang JW, Siegel ER, Linskey M. Weaponizing human EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) for 21st century cancer therapeutics. Oncoscience. 2016; 3(7-8):208-219. PMID: 27713911.
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    7. Hu Y, Ke C, Ru N, Chen Y, Yu L, Siegel ER, Linskey M, Wang P, Zhou YH. Cell context-dependent dual effects of EFEMP1 stabilizes subpopulation equilibrium in responding to changes of in vivo growth environment. Oncotarget. 2015 Oct 13; 6(31):30762-72. PMID: 26307682; PMCID: PMC4741566.
    8. Maducdoc MM, Ghavami Y, Linskey M, Djalilian HR. Evaluation of Reported Malignant Transformation of Vestibular Schwannoma: De Novo and After Stereotactic Radiosurgery or Surgery. Otol Neurotol. 2015 Sep; 36(8):1301-8. PMID: 26134937.
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    9. Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey M, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY. Response assessment criteria for brain metastases: proposal from the RANO group. Lancet Oncol. 2015 Jun; 16(6):e270-8. PMID: 26065612.
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    10. Zakrzewska JM, Linskey M. Trigeminal neuralgia. BMJ. 2015 Mar 12; 350:h1238. PMID: 25767102.
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    11. Zakrzewska JM, Linskey M. Trigeminal neuralgia. BMJ Clin Evid. 2014 Oct 06; 2014. PMID: 25299564.
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    12. Linskey M, Olson JJ, Mitchell LS, Kalkanis SN. Clinical practice guidelines in the AANS/CNS Section on Tumors: past, present and future directions. J Neurooncol. 2014 Sep; 119(3):557-68. PMID: 25081972.
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    13. Ke C, Tran K, Chen Y, Di Donato AT, Yu L, Hu Y, Linskey M, Wang PH, Limoli CL, Zhou YH. Linking differential radiation responses to glioma heterogeneity. Oncotarget. 2014 Mar 30; 5(6):1657-65. PMID: 24722169; PMCID: PMC4039238.
    14. Hu Y, Gao H, Vo C, Ke C, Pan F, Yu L, Siegel E, Hess KR, Linskey M, Zhou YH. Anti-EGFR function of EFEMP1 in glioma cells and patient prognosis. Oncoscience. 2014; 1(3):205-15. PMID: 25594013; PMCID: PMC4278290.
    15. Zakrzewska JM, Linskey M. Trigeminal neuralgia. BMJ. 2014 Feb 17; 348:g474. PMID: 24534115.
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    16. Linskey M, Johnstone PA, O'Leary M, Goetsch S. Radiation exposure of normal temporal bone structures during stereotactically guided gamma knife surgery for vestibular schwannomas. J Neurosurg. 2013 Dec; 119 Suppl:800-6. PMID: 25077324.
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    17. Linskey M. Stereotactic radiosurgery versus stereotactic radiotherapy for patients with vestibular schwannoma: a Leksell Gamma Knife Society 2000 debate. J Neurosurg. 2013 Dec; 119 Suppl:90-2. PMID: 25077318.
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    18. Linskey M. Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters? J Neurosurg. 2013 Dec; 119 Suppl:129-36. PMID: 25077325.
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    19. Hu Y, Ru N, Xiao H, Chaturbedi A, Hoa NT, Tian XJ, Zhang H, Ke C, Yan F, Nelson J, Li Z, Gramer R, Yu L, Siegel E, Zhang X, Jia Z, Jadus MR, Limoli CL, Linskey M, Xing J, Zhou YH. Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. PLoS One. 2013; 8(11):e80898. PMID: 24282558; PMCID: PMC3839911.
    20. Kondziolka D, Parry PV, Lunsford LD, Kano H, Flickinger JC, Rakfal S, Arai Y, Loeffler JS, Rush S, Knisely JP, Sheehan J, Friedman W, Tarhini AA, Francis L, Lieberman F, Ahluwalia MS, Linskey M, McDermott M, Sperduto P, Stupp R. The accuracy of predicting survival in individual patients with cancer. J Neurosurg. 2014 Jan; 120(1):24-30. PMID: 24160479.
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    21. Lin NU, Lee EQ, Aoyama H, Barani IJ, Baumert BG, Brown PD, Camidge DR, Chang SM, Dancey J, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Lamborn KR, Linskey M, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wefel JS, Wen PY. Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group. Lancet Oncol. 2013 Sep; 14(10):e396-406. PMID: 23993384.
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    22. Lin NU, Wefel JS, Lee EQ, Schiff D, van den Bent MJ, Soffietti R, Suh JH, Vogelbaum MA, Mehta MP, Dancey J, Linskey M, Camidge DR, Aoyama H, Brown PD, Chang SM, Kalkanis SN, Barani IJ, Baumert BG, Gaspar LE, Hodi FS, Macdonald DR, Wen PY. Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group. Lancet Oncol. 2013 Sep; 14(10):e407-16. PMID: 23993385.
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    23. Linskey M. Comment. Neurosurgery. 2012 Oct; 71(4):899. PMID: 23162845.
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    24. Linskey M. Editorial critique. J Trauma Acute Care Surg. 2012 Apr; 72(4):1029-30. PMID: 22590753.
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    25. Chaturbedi A, Yu L, Linskey M, Zhou YH. Detection of 1p19q deletion by real-time comparative quantitative PCR. Biomark Insights. 2012; 7:9-17. PMID: 22403483; PMCID: PMC3290106.
    26. Alexandru D, Bota DA, Linskey M. Epidemiology of central nervous system metastases. Prog Neurol Surg. 2012; 25:13-29. PMID: 22236665.
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    27. Chamberlain MC, Bota DA, Linskey M, Schwartz PH. Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy. Neurology. 2011 Nov 29; 77(22):e135; author reply e135-6. PMID: 22123788.
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    28. Hu Y, Pioli PD, Siegel E, Zhang Q, Nelson J, Chaturbedi A, Mathews MS, Ro DI, Alkafeef S, Hsu N, Hamamura M, Yu L, Hess KR, Tromberg BJ, Linskey M, Zhou YH. EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment. Mol Cancer. 2011 Sep 28; 10:123. PMID: 21955618; PMCID: PMC3204287.
    29. Mathews MS, Su J, Heidari E, Levy EI, Linskey M, Chen Z. Neuroendovascular optical coherence tomography imaging and histological analysis. Neurosurgery. 2011 Aug; 69(2):430-9. PMID: 21358358; PMCID: PMC3337214.
    30. Mathews MS, Bota DA, Kim RC, Hasso AN, Linskey M. Primary leptomeningeal plasmablastic lymphoma. J Neurooncol. 2011 Sep; 104(3):835-8. PMID: 21359853; PMCID: PMC3171045.
    31. Gong X, Schwartz PH, Linskey M, Bota DA. Neural stem/progenitors and glioma stem-like cells have differential sensitivity to chemotherapy. Neurology. 2011 Mar 29; 76(13):1126-34. PMID: 21346220; PMCID: PMC3269770.
    32. Bhangoo SS, Linskey M, Kalkanis SN. Evidence-based guidelines for the management of brain metastases. Neurosurg Clin N Am. 2011 Jan; 22(1):97-104, viii. PMID: 21109154.
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    33. Zhou YH, Hess KR, Raj VR, Yu L, Liu L, Yung AW, Linskey M. Establishment of prognostic models for astrocytic and oligodendroglial brain tumors with standardized quantification of marker gene expression and clinical variables. Biomark Insights. 2010 Dec 22; 5:153-68. PMID: 21234290; PMCID: PMC3018892.
    34. Linskey M. Implementing traumatic cervical spine clearance clinical practice guidelines. J Trauma. 2010 Jun; 68(6):1451-2. PMID: 20539188.
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    35. Linskey M. Defining excellence in evidence-based medicine clinical practice guidelines. Clin Neurosurg. 2010; 57:28-37. PMID: 21280492.
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    36. Linskey M, Kalkanis SN. Evidence-linked, clinical practice guidelines-getting serious; getting professional. J Neurooncol. 2010 Jan; 96(1):1-5. PMID: 19957010; PMCID: PMC2810238.
    37. Linskey M, Andrews DW, Asher AL, Burri SH, Kondziolka D, Robinson PD, Ammirati M, Cobbs CS, Gaspar LE, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Kalkanis SN. The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):45-68. PMID: 19960227; PMCID: PMC2808519.
    38. Mehta MP, Paleologos NA, Mikkelsen T, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey M, Loeffler JS, McDermott M, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN. The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):71-83. PMID: 19960229; PMCID: PMC2808518.
    39. Kalkanis SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, Ammirati M, Robinson PD, Andrews DW, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Linskey M. The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):33-43. PMID: 19960230; PMCID: PMC2808516.
    40. Gaspar LE, Mehta MP, Patchell RA, Burri SH, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Cobbs CS, Kondziolka D, Linskey M, Loeffler JS, McDermott M, Mikkelsen T, Olson JJ, Paleologos NA, Ryken TC, Kalkanis SN. The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):17-32. PMID: 19960231; PMCID: PMC2808517.
    41. Kalkanis SN, Linskey M. Evidence-based clinical practice parameter guidelines for the treatment of patients with metastatic brain tumors: introduction. J Neurooncol. 2010 Jan; 96(1):7-10. PMID: 19957011; PMCID: PMC2808533.
    42. Robinson PD, Kalkanis SN, Linskey M, Santaguida PL. Methodology used to develop the AANS/CNS management of brain metastases evidence-based clinical practice parameter guidelines. J Neurooncol. 2010 Jan; 96(1):11-6. PMID: 19957012; PMCID: PMC2808528.
    43. Olson JJ, Paleologos NA, Gaspar LE, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Kondziolka D, Linskey M, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Patchell RA, Ryken TC, Kalkanis SN. The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics. J Neurooncol. 2010 Jan; 96(1):115-42. PMID: 19957013; PMCID: PMC2808529.
    44. Ryken TC, McDermott M, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey M, Loeffler JS, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Kalkanis SN. The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):103-14. PMID: 19957014; PMCID: PMC2808527.
    45. Mikkelsen T, Paleologos NA, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey M, Loeffler JS, McDermott M, Mehta MP, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN. The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):97-102. PMID: 19957015; PMCID: PMC2808526.
    46. Ammirati M, Cobbs CS, Linskey M, Paleologos NA, Ryken TC, Burri SH, Asher AL, Loeffler JS, Robinson PD, Andrews DW, Gaspar LE, Kondziolka D, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Patchell RA, Kalkanis SN. The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):85-96. PMID: 19957016; PMCID: PMC2808530.
    47. Scarrow AM, Linskey M, Asher AL, Anderson VC, Selden NR. Neurosurgeon transition to retirement: results of the 2007 Congress of Neurological Surgeons Consensus Conference. Neurosurgery. 2009 Aug; 65(2):231-5; discussion 235-6. PMID: 19625900.
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    48. Zhou YH, Hu Y, Mayes D, Siegel E, Kim JG, Mathews MS, Hsu N, Eskander D, Yu O, Tromberg BJ, Linskey M. PAX6 suppression of glioma angiogenesis and the expression of vascular endothelial growth factor A. J Neurooncol. 2010 Jan; 96(2):191-200. PMID: 19618119; PMCID: PMC2808537.
    49. Owen CM, Linskey M. Frame-based stereotaxy in a frameless era: current capabilities, relative role, and the positive- and negative predictive values of blood through the needle. J Neurooncol. 2009 May; 93(1):139-49. PMID: 19430891.
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    50. Zakrzewska JM, Linskey M. Trigeminal neuralgia. BMJ Clin Evid. 2009 Mar 12; 2009. PMID: 19445753; PMCID: PMC2907816.
    51. Abookasis D, Lay CC, Mathews MS, Linskey M, Frostig RD, Tromberg BJ. Imaging cortical absorption, scattering, and hemodynamic response during ischemic stroke using spatially modulated near-infrared illumination. J Biomed Opt. 2009 Mar-Apr; 14(2):024033. PMID: 19405762; PMCID: PMC2868516.
    52. Linskey M. Hearing preservation in vestibular schwannoma stereotactic radiosurgery: what really matters? J Neurosurg. 2008 Dec; 109 Suppl:129-36. PMID: 19123899.
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    53. Linskey M, Ratanatharathorn V, Peñagaricano J. A prospective cohort study of microvascular decompression and Gamma Knife surgery in patients with trigeminal neuralgia. J Neurosurg. 2008 Dec; 109 Suppl:160-72. PMID: 19123904.
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    54. Linskey M. The emergence of clinical practice parameter guidelines in neuro-oncology: promise of utility tempered with caution. J Neurooncol. 2008 Sep; 89(3):359-62. PMID: 18712285.
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    55. Mathews MS, Linskey M, Binder DK. William P. van Wagenen and the first corpus callosotomies for epilepsy. J Neurosurg. 2008 Mar; 108(3):608-13. PMID: 18312112.
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    56. Mathews MS, Linskey M, Hasso AN, Fruehauf JP. The effect of bevacizumab (Avastin) on neuroimaging of brain metastases. Surg Neurol. 2008 Dec; 70(6):649-52; discussion 653. PMID: 18261776.
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    57. Westhout FD, Linskey M. Obstructive hydrocephalus and progressive psychosis: rare presentations of neurosarcoidosis. Surg Neurol. 2008 Mar; 69(3):288-92; discussion 292. PMID: 17976699.
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    58. Westhout FD, Mathews M, Paré LS, Armstrong WB, Tully P, Linskey M. Recognizing schwannomatosis and distinguishing it from neurofibromatosis type 1 or 2. J Spinal Disord Tech. 2007 Jun; 20(4):329-32. PMID: 17538359.
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    59. Linskey M. Neurosurgery quality: pay-for-performance, guidelines, and outcome measures. Clin Neurosurg. 2007; 54:157-79. PMID: 18504914.
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    60. Barnett GH, Linskey M, Adler JR, Cozzens JW, Friedman WA, Heilbrun MP, Lunsford LD, Schulder M, Sloan AE. Stereotactic radiosurgery--an organized neurosurgery-sanctioned definition. J Neurosurg. 2007 Jan; 106(1):1-5. PMID: 17240553.
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    61. Westhout FD, Paré LS, Linskey M. Central causes of foot drop: rare and underappreciated differential diagnoses. J Spinal Cord Med. 2007; 30(1):62-6. PMID: 17385271; PMCID: PMC2031999.
    62. Vokes DE, Linskey M, Armstrong WB. Propofol lipemia mimicking chyle leak during neck dissection. Head Neck. 2006 Dec; 28(12):1147-9. PMID: 16983690.
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    63. Peñagarícano JA, Yan Y, Shi C, Linskey M, Ratanatharathorn V. Dosimetric comparison of helical tomotherapy and Gamma Knife stereotactic radiosurgery for single brain metastasis. Radiat Oncol. 2006 Aug 03; 1:26. PMID: 16887031; PMCID: PMC1557668.
    64. Knisely JP, Linskey M. Less common indications for stereotactic radiosurgery or fractionated radiotherapy for patients with benign brain tumors. Neurosurg Clin N Am. 2006 Apr; 17(2):149-67, vii. PMID: 16793507.
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    65. Linskey M. Evidence-based medicine for neurosurgeons: introduction and methodology. Prog Neurol Surg. 2006; 19:1-53. PMID: 17033146.
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    66. Zhou YH, Hess KR, Liu L, Linskey M, Yung WK. Modeling prognosis for patients with malignant astrocytic gliomas: quantifying the expression of multiple genetic markers and clinical variables. Neuro Oncol. 2005 Oct; 7(4):485-94. PMID: 16212813; PMCID: PMC1871729.
    67. Linskey M, Davis SA, Ratanatharathorn V. Relative roles of microsurgery and stereotactic radiosurgery for the treatment of patients with cranial meningiomas: a single-surgeon 4-year integrated experience with both modalities. J Neurosurg. 2005 Jan; 102 Suppl:59-70. PMID: 15662783.
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    68. Linskey M, Davis SA, Ratanatharathorn V. Relative roles of microsurgery and stereotactic radiosurgery for the treatment of patients with cranial meningiomas: a single-surgeon 4-year integrated experience with both modalities. J Neurosurg. 2005 Jan; 102(s_supplement):59-70. PMID: 28306454.
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    69. Peñagarícano JA, Linskey M, Ratanatharathorn V. Accelerated cerebral vasculopathy after radiation therapy to the brain. Neurol India. 2004 Dec; 52(4):482-6. PMID: 15626839.
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    70. Barker FG, Linskey M. History of the AANS/CNS joint section on tumors and preface to the 20th anniversary Journal of Neuro-Oncology Special Issue. J Neurooncol. 2004 Aug-Sep; 69(1-3):1-18. PMID: 15527076.
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    71. Linskey M. The changing role of stereotaxis in surgical neuro-oncology. J Neurooncol. 2004 Aug-Sep; 69(1-3):35-54. PMID: 15527079.
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    72. Elshihabi S, Husain M, Linskey M. Lipomatous medulloblastoma: a rare adult tumor variant with a uniquely favorable prognosis. Surg Neurol. 2003 Dec; 60(6):566-70. PMID: 14670682.
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    73. Linskey M, Johnstone PA. Radiation tolerance of normal temporal bone structures: implications for gamma knife stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2003 Sep 01; 57(1):196-200. PMID: 12909233.
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    74. Sawyer JR, Sammartino G, Husain M, Linskey M. Constitutional t(16;22)(p13.3;q11.2 approximately 12) in a primitive neuroectodermal tumor of the pineal region. Cancer Genet Cytogenet. 2003 Apr 01; 142(1):73-6. PMID: 12660038.
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    75. Linskey M, Johnstone PA, O'Leary M, Goetsch S. Radiation exposure of normal temporal bone structures during stereotactically guided gamma knife surgery for vestibular schwannomas. J Neurosurg. 2003 Apr; 98(4):800-6. PMID: 12691405.
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    76. Gardner E, Linskey M, Peñagarícano JA, Hanna EY. Stereotactic radiosurgery for patients with cancer of the head and neck. Curr Oncol Rep. 2003 Mar; 5(2):164-9. PMID: 12583835.
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