Michelle Khine

Title(s)Professor, Biomedical Engineering
SchoolSamueli School of Engineering
Address3422 Engineering III
Zot 2715
Irvine CA 92697
Phone(949) 824-4051
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    Collapse Research 
    Collapse Research Activities and Funding
    Enhancing Biomedical Engineering Education Clinical Needs Finding Courses through Immersive and Virtual Experiences
    NIH R25EB031116Sep 1, 2021 - May 31, 2026
    Role: Co-Principal Investigator
    Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)
    NIH DP2OD007283Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    High Throughput Intracellular Drug Screening Platform
    NIH R43GM075509Sep 15, 2005 - Mar 14, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Improved sleep stage predictions by deep learning of photoplethysmogram and respiration patterns. Comput Biol Med. 2024 Jul 20; 179:108679. Kazemi K, Abiri A, Zhou Y, Rahmani A, Khayat RN, Liljeberg P, Khine M. PMID: 39033682.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Wireless and Battery-Free Sensor for Interstitial Fluid Pressure Monitoring. Sensors (Basel). 2024 Jul 09; 24(14). Qian C, Ye F, Li J, Tseng P, Khine M. PMID: 39065827; PMCID: PMC11280719.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Multimodal diagnosis of cerebrospinal fluid rhinorrhea: State of the art review and emerging concepts. Laryngoscope Investig Otolaryngol. 2024 Jun; 9(3):e1272. Torabi SJ, Abiri A, Chen X, Senel M, Hsu FPK, Lupták A, Khine M, Kuan EC. PMID: 38803458; PMCID: PMC11129547.
      View in: PubMed   Mentions:
    4. Amphibious epidermal area networks for uninterrupted wireless data and power transfer. Nat Commun. 2023 Nov 18; 14(1):7522. Hajiaghajani A, Rwei P, Afandizadeh Zargari AH, Escobar AR, Kurdahi F, Khine M, Tseng P. PMID: 37980425; PMCID: PMC10657464.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Changes in beat-to-beat blood pressure and pulse rate variability following stroke. Sci Rep. 2023 11 07; 13(1):19245. Abiri A, Chou EF, Shen W, Fisher MJ, Khine M. PMID: 37935766; PMCID: PMC10630489.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Editorial: Clinical validation of digital health technologies for personalized medicine. Front Digit Health. 2022; 4:831517. Khine M. PMID: 37179533; PMCID: PMC10173149.
      View in: PubMed   Mentions: 1  
    7. Intra-beat biomarker for accurate continuous non-invasive blood pressure monitoring. Sci Rep. 2022 10 06; 12(1):16772. Abiri A, Chou EF, Qian C, Rinehart J, Khine M. PMID: 36202815; PMCID: PMC9537243.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Breast cancer detection by analyzing the volatile organic compound (VOC) signature in human urine. Sci Rep. 2022 09 01; 12(1):14873. Giró Benet J, Seo M, Khine M, Gumà Padró J, Pardo Martnez A, Kurdahi F. PMID: 36050339; PMCID: PMC9435419.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    9. Effects of ECG Data Length on Heart Rate Variability among Young Healthy Adults. Sensors (Basel). 2021 Sep 19; 21(18). Chou EF, Khine M, Lockhart T, Soangra R. PMID: 34577492; PMCID: PMC8472063.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Clinical Validation of a Soft Wireless Continuous Blood Pressure Sensor During Surgery. Front Digit Health. 2021; 3:696606. Chou EF, Cheung SYC, Maxwell HC, Pham N, Khine M, Rinehart J. PMID: 34713172; PMCID: PMC8521971.
      View in: PubMed   Mentions: 1  
    11. Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes. Anal Methods. 2021 02 25; 13(7):874-883. Zakashansky JA, Imamura AH, Salgado DF, Romero Mercieca HC, Aguas RFL, Lao AM, Pariser J, Arroyo-Currás N, Khine M. PMID: 33576354.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    12. The Effect of Encapsulation on Crack-Based Wrinkled Thin Film Soft Strain Sensors. Materials (Basel). 2021 Jan 13; 14(2). Nguyen T, Chu M, Tu R, Khine M. PMID: 33450998; PMCID: PMC7828450.
      View in: PubMed   Mentions: 4  
    13. A wrinkled structure of gold film greatly improves the signaling of electrochemical aptamer-based biosensors. RSC Adv. 2020 Dec 24; 11(2):671-677. Li S, Lin L, Chang X, Si Z, Plaxco KW, Khine M, Li H, Xia F. PMID: 35423693; PMCID: PMC8693351.
      View in: PubMed   Mentions: 8  
    14. High-resolution integrated piezoresistive sensors for microfluidic monitoring. Lab Chip. 2021 01 07; 21(1):83-92. Zhou Y, Werner EM, Lee E, Chu M, Nguyen T, Costa KD, Hui EE, Khine M. PMID: 33300516; PMCID: PMC9521707.
      View in: PubMed   Mentions:    Fields:    
    15. Advances in Materials for Soft Stretchable Conductors and Their Behavior under Mechanical Deformation. Polymers (Basel). 2020 Jun 29; 12(7). Nguyen T, Khine M. PMID: 32610500; PMCID: PMC7408380.
      View in: PubMed   Mentions: 2  
    16. Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation as Revealed by Optical Mapping of Action Potentials and Calcium Transients. Front Physiol. 2020; 11:165. Wong AO, Wong N, Geng L, Chow MZ, Lee EK, Wu H, Khine M, Kong CW, Costa KD, Keung W, Cheung YF, Li RA. PMID: 32226389; PMCID: PMC7080659.
      View in: PubMed   Mentions: 9  
    17. Soft Wearable Pressure Sensors for Beat-to-Beat Blood Pressure Monitoring. Adv Healthc Mater. 2019 07; 8(13):e1900109. Kim J, Chou EF, Le J, Wong S, Chu M, Khine M. PMID: 31033256.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    18. Respiration rate and volume measurements using wearable strain sensors. NPJ Digit Med. 2019; 2:8. Chu M, Nguyen T, Pandey V, Zhou Y, Pham HN, Bar-Yoseph R, Radom-Aizik S, Jain R, Cooper DM, Khine M. PMID: 31304358; PMCID: PMC6550208.
      View in: PubMed   Mentions: 78  
    19. Chemical Generation of Hydroxyl Radical for Oxidative 'Footprinting'. Protein Pept Lett. 2019; 26(1):61-69. Leser M, Chapman JR, Khine M, Pegan J, Law M, Makkaoui ME, Ueberheide BM, Brenowitz M. PMID: 30543161.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    20. Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells - Tools for analyzing dynamics of cell cycle, migration, and lineage selection. Methods. 2018 01 15; 133:81-90. Piltti KM, Cummings BJ, Carta K, Manughian-Peter A, Worne CL, Singh K, Ong D, Maksymyuk Y, Khine M, Anderson AJ. PMID: 29050826; PMCID: PMC6166405.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    21. Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification. Stem Cell Reports. 2017 11 14; 9(5):1560-1572. Lee EK, Tran DD, Keung W, Chan P, Wong G, Chan CW, Costa KD, Li RA, Khine M. PMID: 29033305; PMCID: PMC5829317.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    22. Leaf-inspired microcontact printing vascular patterns. Biofabrication. 2017 Jun 01; 9(2):021001. Wong L, Pegan JD, Gabela-Zuniga B, Khine M, McCloskey KE. PMID: 28488588.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    23. Plasma free reversible and irreversible microfluidic bonding. Lab Chip. 2017 01 17; 17(2):267-273. Chu M, Nguyen TT, Lee EK, Morival JL, Khine M. PMID: 27990540; PMCID: PMC9300447.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity. Adv Mater. 2017 Jan; 29(1). Shum AM, Che H, Wong AO, Zhang C, Wu H, Chan CW, Costa K, Khine M, Kong CW, Li RA. PMID: 27805726.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    25. Skin-mountable stretch sensor for wearable health monitoring. Nanoscale. 2016 Oct 06; 8(39):17295-17303. Pegan JD, Zhang J, Chu M, Nguyen T, Park SJ, Paul A, Kim J, Bachman M, Khine M. PMID: 27714048; PMCID: PMC9061271.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    26. Multi-scale silica structures for improved HIV-1 Capsid (p24) antigen detection. Analyst. 2016 Jun 20; 141(13):4181-8. Lin S, Hedde PN, Venugopalan V, Gratton E, Khine M. PMID: 27163263; PMCID: PMC4924925.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    27. Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles. Biomater Sci. 2016 Jun 24; 4(6):948-52. Wang T, Luu TU, Chen A, Khine M, Liu WF. PMID: 27125253; PMCID: PMC9061279.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    28. Nanotextured Shrink Wrap Superhydrophobic Surfaces by Argon Plasma Etching. Materials (Basel). 2016 Mar 14; 9(3). Nokes JM, Sharma H, Tu R, Kim MY, Chu M, Siddiqui A, Khine M. PMID: 28773318; PMCID: PMC5456652.
      View in: PubMed   Mentions: 3  
    29. Tunable optical response of bowtie nanoantenna arrays on thermoplastic substrates. Nanotechnology. 2016 Mar 11; 27(10):105302. Sharac N, Sharma H, Veysi M, Sanderson RN, Khine M, Capolino F, Ragan R. PMID: 26867001.
      View in: PubMed   Mentions: 1     Fields:    
    30. Highly stretchable wrinkled gold thin film wires. Appl Phys Lett. 2016 Feb 08; 108(6):061901. Kim J, Park SJ, Nguyen T, Chu M, Pegan JD, Khine M. PMID: 26937042; PMCID: PMC4752533.
      View in: PubMed   Mentions: 10  
    31. Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics. Adv Healthc Mater. 2016 Mar 09; 5(5):593-601. Nokes JM, Liedert R, Kim MY, Siddiqui A, Chu M, Lee EK, Khine M. PMID: 26784916; PMCID: PMC9431487.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    32. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. Sci Rep. 2015 Jul 03; 5:11817. Lee EK, Kurokawa YK, Tu R, George SC, Khine M. PMID: 26139150; PMCID: PMC4490343.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    33. Protein footprinting by pyrite shrink-wrap laminate. Lab Chip. 2015 Apr 07; 15(7):1646-50. Leser M, Pegan J, El Makkaoui M, Schlatterer JC, Khine M, Law M, Brenowitz M. PMID: 25666234; PMCID: PMC9431544.
      View in: PubMed   Mentions: 1     Fields:    
    34. Shrink-induced silica multiscale structures for enhanced fluorescence from DNA microarrays. Langmuir. 2014 Sep 23; 30(37):10979-83. Sharma H, Wood JB, Lin S, Corn RM, Khine M. PMID: 25191785; PMCID: PMC4172299.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    35. Thermally-induced miniaturization for micro- and nanofabrication: progress and updates. Lab Chip. 2014 Sep 21; 14(18):3475-88. Lin S, Lee EK, Nguyen N, Khine M. PMID: 25075652; PMCID: PMC9061274.
      View in: PubMed   Mentions: 10     Fields:    
    36. Shrink-induced biomimetic wrinkled substrates for functional cardiac cell alignment and culture. Methods Mol Biol. 2014; 1181:97-108. Mendoza N, Tu R, Chen A, Lee E, Khine M. PMID: 25070330.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    37. Enhanced emission of fluorophores on shrink-induced wrinkled composite structures. Opt Mater Express. 2014; 4(4):753-763. Sharma H, Digman MA, Felsinger N, Gratton E, Khine M. PMID: 25383253; PMCID: PMC4220269.
      View in: PubMed   Mentions: 1  
    38. Flexible shrink-induced high surface area electrodes for electrochemiluminescent sensing. Lab Chip. 2013 Nov 07; 13(21):4205-9. Pegan JD, Ho AY, Bachman M, Khine M. PMID: 24056907.
      View in: PubMed   Mentions: 12     Fields:    
    39. Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells. Biomaterials. 2014 Jan; 35(2):675-83. Chen A, Lee E, Tu R, Santiago K, Grosberg A, Fowlkes C, Khine M. PMID: 24144905; PMCID: PMC9300448.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    40. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 2013 Nov; 34(35):8878-86. Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. PMID: 23942210.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    41. Shrink-induced sorting using integrated nanoscale magnetic traps. Appl Phys Lett. 2013 Feb 11; 102(6):63504. Nawarathna D, Norouzi N, McLane J, Sharma H, Sharac N, Grant T, Chen A, Strayer S, Ragan R, Khine M. PMID: 23479497; PMCID: PMC3585756.
      View in: PubMed   Mentions: 12  
    42. Tracking the mechanical dynamics of human embryonic stem cell chromatin. Epigenetics Chromatin. 2012 Dec 21; 5(1):20. Hinde E, Cardarelli F, Chen A, Khine M, Gratton E. PMID: 23259580; PMCID: PMC3570407.
      View in: PubMed   Mentions: 8     Fields:    
    43. Shrink-induced superhydrophobic and antibacterial surfaces in consumer plastics. PLoS One. 2012; 7(8):e40987. Freschauf LR, McLane J, Sharma H, Khine M. PMID: 22916100; PMCID: PMC3423404.
      View in: PubMed   Mentions: 18     Fields:    
    44. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Adv Mater. 2011 Dec 22; 23(48):5785-91. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. PMID: 22065428.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    45. Shrink-induced single-cell plastic microwell array. J Lab Autom. 2011 Dec; 16(6):450-6. Lew V, Nguyen D, Khine M. PMID: 22093302.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    46. Sequential shrink photolithography for plastic microlens arrays. Appl Phys Lett. 2011 Jul 18; 99(3):34102-341023. Dyer D, Shreim S, Jayadev S, Lew V, Botvinick E, Khine M. PMID: 21863126; PMCID: PMC3155578.
      View in: PubMed   Mentions: 4  
    47. Shrink-film microfluidic education modules: Complete devices within minutes. Biomicrofluidics. 2011 Jun; 5(2):22209. Nguyen D, McLane J, Lew V, Pegan J, Khine M. PMID: 21799715; PMCID: PMC3145234.
      View in: PubMed   Mentions: 14  
    48. Multiscale biomimetic topography for the alignment of neonatal and embryonic stem cell-derived heart cells. Tissue Eng Part C Methods. 2011 May; 17(5):579-88. Luna JI, Ciriza J, Garcia-Ojeda ME, Kong M, Herren A, Lieu DK, Li RA, Fowlkes CC, Khine M, McCloskey KE. PMID: 21235325.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    49. Unconventional low-cost fabrication and patterning techniques for point of care diagnostics. Ann Biomed Eng. 2011 Apr; 39(4):1313-27. Sharma H, Nguyen D, Chen A, Lew V, Khine M. PMID: 21152984; PMCID: PMC3069320.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    50. Shrink film patterning by craft cutter: complete plastic chips with high resolution/high-aspect ratio channel. Lab Chip. 2010 Sep 21; 10(18):2472-5. Taylor D, Dyer D, Lew V, Khine M. PMID: 20680207.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    51. Scattering of light by molecules over a rough surface. J Opt Soc Am A Opt Image Sci Vis. 2010 May 01; 27(5):1002-11. Long M, Khine M, Kim AD. PMID: 20448766.
      View in: PubMed   Mentions:    Fields:    
    52. Better shrinkage than Shrinky-Dinks. Lab Chip. 2010 Jun 21; 10(12):1623-6. Nguyen D, Taylor D, Qian K, Norouzi N, Rasmussen J, Botzet S, Lehmann M, Halverson K, Khine M. PMID: 20517559.
      View in: PubMed   Mentions: 13     Fields:    
    53. Tunable shrink-induced honeycomb microwell arrays for uniform embryoid bodies. Lab Chip. 2009 Dec 07; 9(23):3338-44. Nguyen D, Sa S, Pegan JD, Rich B, Xiang G, McCloskey KE, Manilay JO, Khine M. PMID: 19904398.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    54. Shrinky-dink hanging drops: a simple way to form and culture embryoid bodies. J Vis Exp. 2008 Mar 05; (13). Chen CS, Pegan J, Luna J, Xia B, McCloskey K, Chin WC, Khine M. PMID: 19066572; PMCID: PMC2586867.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    55. Shrinky-Dink microfluidics: 3D polystyrene chips. Lab Chip. 2008 Apr; 8(4):622-4. Chen CS, Breslauer DN, Luna JI, Grimes A, Chin WC, Lee LP, Khine M. PMID: 18369519.
      View in: PubMed   Mentions: 37     Fields:    
    56. Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns. Lab Chip. 2008 Jan; 8(1):170-2. Grimes A, Breslauer DN, Long M, Pegan J, Lee LP, Khine M. PMID: 18094775.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    57. Single-cell electroporation arrays with real-time monitoring and feedback control. Lab Chip. 2007 Apr; 7(4):457-62. Khine M, Ionescu-Zanetti C, Blatz A, Wang LP, Lee LP. PMID: 17389961.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    58. A single cell electroporation chip. Lab Chip. 2005 Jan; 5(1):38-43. Khine M, Lau A, Ionescu-Zanetti C, Seo J, Lee LP. PMID: 15616738.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCells
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