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Michelle Khine

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentBiomedical Engineering
Address3422 Engineering III
Zot 2715
Irvine CA 92697
Phone(949) 824-4051
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    Collapse Research 
    Collapse Research Activities and Funding
    Shrink Induced Manufacturing Platform for Low-Cost Diagnostics (SIMPL-CD)
    NIH DP2OD007283Sep 30, 2010 - Jun 30, 2015
    Role: Principal Investigator
    High Throughput Intracellular Drug Screening Platform
    NIH/NIGMS R43GM075509Sep 15, 2005 - Mar 14, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Piltti KM, Cummings BJ, Carta K, Manughian-Peter A, Worne CL, Singh K, Ong D, Maksymyuk Y, Khine M, Anderson AJ. Live-cell time-lapse imaging and single-cell tracking of in vitro cultured neural stem cells - Tools for analyzing dynamics of cell cycle, migration, and lineage selection. Methods. 2018 Jan 15; 133:81-90. PMID: 29050826.
      View in: PubMed
    2. Lee EK, Tran DD, Keung W, Chan P, Wong G, Chan CW, Costa KD, Li RA, Khine M. Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification. Stem Cell Reports. 2017 11 14; 9(5):1560-1572. PMID: 29033305.
      View in: PubMed
    3. Wong L, Pegan JD, Gabela-Zuniga B, Khine M, McCloskey KE. Leaf-inspired microcontact printing vascular patterns. Biofabrication. 2017 Jun 01; 9(2):021001. PMID: 28488588.
      View in: PubMed
    4. Chu M, Nguyen TT, Lee EK, Morival JL, Khine M. Plasma free reversible and irreversible microfluidic bonding. Lab Chip. 2017 01 17; 17(2):267-273. PMID: 27990540.
      View in: PubMed
    5. Shum AM, Che H, Wong AO, Zhang C, Wu H, Chan CW, Costa K, Khine M, Kong CW, Li RA. A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity. Adv Mater. 2017 Jan; 29(1). PMID: 27805726.
      View in: PubMed
    6. Pegan JD, Zhang J, Chu M, Nguyen T, Park SJ, Paul A, Kim J, Bachman M, Khine M. Skin-mountable stretch sensor for wearable health monitoring. Nanoscale. 2016 Oct 06; 8(39):17295-17303. PMID: 27714048.
      View in: PubMed
    7. Lin S, Hedde PN, Venugopalan V, Gratton E, Khine M. Multi-scale silica structures for improved HIV-1 Capsid (p24) antigen detection. Analyst. 2016 Jun 20; 141(13):4181-8. PMID: 27163263.
      View in: PubMed
    8. Wang T, Luu TU, Chen A, Khine M, Liu WF. Topographical modulation of macrophage phenotype by shrink-film multi-scale wrinkles. Biomater Sci. 2016 Jun 24; 4(6):948-52. PMID: 27125253.
      View in: PubMed
    9. Nokes JM, Sharma H, Tu R, Kim MY, Chu M, Siddiqui A, Khine M. Nanotextured Shrink Wrap Superhydrophobic Surfaces by Argon Plasma Etching. Materials (Basel). 2016 Mar 14; 9(3). PMID: 28773318.
      View in: PubMed
    10. Kim J, Park SJ, Nguyen T, Chu M, Pegan JD, Khine M. Highly stretchable wrinkled gold thin film wires. Appl Phys Lett. 2016 Feb 08; 108(6):061901. PMID: 26937042.
      View in: PubMed
    11. Nokes JM, Liedert R, Kim MY, Siddiqui A, Chu M, Lee EK, Khine M. Reduced Blood Coagulation on Roll-to-Roll, Shrink-Induced Superhydrophobic Plastics. Adv Healthc Mater. 2016 Mar 09; 5(5):593-601. PMID: 26784916.
      View in: PubMed
    12. Lee EK, Kurokawa YK, Tu R, George SC, Khine M. Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. Sci Rep. 2015 Jul 03; 5:11817. PMID: 26139150; PMCID: PMC4490343.
    13. Leser M, Pegan J, El Makkaoui M, Schlatterer JC, Khine M, Law M, Brenowitz M. Protein footprinting by pyrite shrink-wrap laminate. Lab Chip. 2015 Apr 07; 15(7):1646-50. PMID: 25666234.
      View in: PubMed
    14. Sharma H, Wood JB, Lin S, Corn RM, Khine M. Shrink-induced silica multiscale structures for enhanced fluorescence from DNA microarrays. Langmuir. 2014 Sep 23; 30(37):10979-83. PMID: 25191785; PMCID: PMC4172299.
    15. Lin S, Lee EK, Nguyen N, Khine M. Thermally-induced miniaturization for micro- and nanofabrication: progress and updates. Lab Chip. 2014 Sep 21; 14(18):3475-88. PMID: 25075652.
      View in: PubMed
    16. Mendoza N, Tu R, Chen A, Lee E, Khine M. Shrink-induced biomimetic wrinkled substrates for functional cardiac cell alignment and culture. Methods Mol Biol. 2014; 1181:97-108. PMID: 25070330.
      View in: PubMed
    17. Sharma H, Digman MA, Felsinger N, Gratton E, Khine M. Enhanced emission of fluorophores on shrink-induced wrinkled composite structures. Opt Mater Express. 2014; 4(4):753-763. PMID: 25383253.
      View in: PubMed
    18. Pegan JD, Ho AY, Bachman M, Khine M. Flexible shrink-induced high surface area electrodes for electrochemiluminescent sensing. Lab Chip. 2013 Nov 07; 13(21):4205-9. PMID: 24056907.
      View in: PubMed
    19. Chen A, Lee E, Tu R, Santiago K, Grosberg A, Fowlkes C, Khine M. Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells. Biomaterials. 2014 Jan; 35(2):675-83. PMID: 24144905.
      View in: PubMed
    20. Wang J, Chen A, Lieu DK, Karakikes I, Chen G, Keung W, Chan CW, Hajjar RJ, Costa KD, Khine M, Li RA. Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias. Biomaterials. 2013 Nov; 34(35):8878-86. PMID: 23942210.
      View in: PubMed
    21. Nawarathna D, Norouzi N, McLane J, Sharma H, Sharac N, Grant T, Chen A, Strayer S, Ragan R, Khine M. Shrink-induced sorting using integrated nanoscale magnetic traps. Appl Phys Lett. 2013 Feb 11; 102(6):63504. PMID: 23479497.
      View in: PubMed
    22. Hinde E, Cardarelli F, Chen A, Khine M, Gratton E. Tracking the mechanical dynamics of human embryonic stem cell chromatin. Epigenetics Chromatin. 2012 Dec 21; 5(1):20. PMID: 23259580; PMCID: PMC3570407.
    23. Freschauf LR, McLane J, Sharma H, Khine M. Shrink-induced superhydrophobic and antibacterial surfaces in consumer plastics. PLoS One. 2012; 7(8):e40987. PMID: 22916100; PMCID: PMC3423404.
    24. Chen A, Lieu DK, Freschauf L, Lew V, Sharma H, Wang J, Nguyen D, Karakikes I, Hajjar RJ, Gopinathan A, Botvinick E, Fowlkes CC, Li RA, Khine M. Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives. Adv Mater. 2011 Dec 22; 23(48):5785-91. PMID: 22065428.
      View in: PubMed
    25. Lew V, Nguyen D, Khine M. Shrink-induced single-cell plastic microwell array. J Lab Autom. 2011 Dec; 16(6):450-6. PMID: 22093302.
      View in: PubMed
    26. Dyer D, Shreim S, Jayadev S, Lew V, Botvinick E, Khine M. Sequential shrink photolithography for plastic microlens arrays. Appl Phys Lett. 2011 Jul 18; 99(3):34102-341023. PMID: 21863126.
      View in: PubMed
    27. Nguyen D, McLane J, Lew V, Pegan J, Khine M. Shrink-film microfluidic education modules: Complete devices within minutes. Biomicrofluidics. 2011 Jun; 5(2):22209. PMID: 21799715; PMCID: PMC3145234.
    28. Luna JI, Ciriza J, Garcia-Ojeda ME, Kong M, Herren A, Lieu DK, Li RA, Fowlkes CC, Khine M, McCloskey KE. Multiscale biomimetic topography for the alignment of neonatal and embryonic stem cell-derived heart cells. Tissue Eng Part C Methods. 2011 May; 17(5):579-88. PMID: 21235325.
      View in: PubMed
    29. Sharma H, Nguyen D, Chen A, Lew V, Khine M. Unconventional low-cost fabrication and patterning techniques for point of care diagnostics. Ann Biomed Eng. 2011 Apr; 39(4):1313-27. PMID: 21152984; PMCID: PMC3069320.
    30. Taylor D, Dyer D, Lew V, Khine M. Shrink film patterning by craft cutter: complete plastic chips with high resolution/high-aspect ratio channel. Lab Chip. 2010 Sep 21; 10(18):2472-5. PMID: 20680207.
      View in: PubMed
    31. Long M, Khine M, Kim AD. Scattering of light by molecules over a rough surface. J Opt Soc Am A Opt Image Sci Vis. 2010 May 01; 27(5):1002-11. PMID: 20448766.
      View in: PubMed
    32. Nguyen D, Taylor D, Qian K, Norouzi N, Rasmussen J, Botzet S, Lehmann M, Halverson K, Khine M. Better shrinkage than Shrinky-Dinks. Lab Chip. 2010 Jun 21; 10(12):1623-6. PMID: 20517559.
      View in: PubMed
    33. Nguyen D, Sa S, Pegan JD, Rich B, Xiang G, McCloskey KE, Manilay JO, Khine M. Tunable shrink-induced honeycomb microwell arrays for uniform embryoid bodies. Lab Chip. 2009 Dec 07; 9(23):3338-44. PMID: 19904398.
      View in: PubMed
    34. Chen CS, Pegan J, Luna J, Xia B, McCloskey K, Chin WC, Khine M. Shrinky-dink hanging drops: a simple way to form and culture embryoid bodies. J Vis Exp. 2008 Mar 05; (13). PMID: 19066572; PMCID: PMC2586867.
    35. Chen CS, Breslauer DN, Luna JI, Grimes A, Chin WC, Lee LP, Khine M. Shrinky-Dink microfluidics: 3D polystyrene chips. Lab Chip. 2008 Apr; 8(4):622-4. PMID: 18369519.
      View in: PubMed
    36. Grimes A, Breslauer DN, Long M, Pegan J, Lee LP, Khine M. Shrinky-Dink microfluidics: rapid generation of deep and rounded patterns. Lab Chip. 2008 Jan; 8(1):170-2. PMID: 18094775.
      View in: PubMed
    37. Khine M, Ionescu-Zanetti C, Blatz A, Wang LP, Lee LP. Single-cell electroporation arrays with real-time monitoring and feedback control. Lab Chip. 2007 Apr; 7(4):457-62. PMID: 17389961.
      View in: PubMed
    38. Khine M, Lau A, Ionescu-Zanetti C, Seo J, Lee LP. A single cell electroporation chip. Lab Chip. 2005 Jan; 5(1):38-43. PMID: 15616738.
      View in: PubMed