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Olivier Cinquin

Title(s)Associate Professor, Developmental & Cell Biology
Phone(949) 257-2819
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    Collapse Research 
    Collapse Research Activities and Funding
    Control of cell cycling speed to delay the onset of senescence
    NIH/NIGMS R01GM102635Aug 20, 2012 - Jul 31, 2017
    Role: Principal Investigator
    Direct tests of the role of stem cells in minimizing mutation accumulation
    NIH/NIA R21AG042125Apr 1, 2012 - Mar 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Holmes WR, Reyes de Mochel NS, Wang Q, Du H, Peng T, Chiang M, Cinquin O, Cho K, Nie Q. Gene Expression Noise Enhances Robust Organization of the Early Mammalian Blastocyst. PLoS Comput Biol. 2017 01; 13(1):e1005320. PMID: 28114387.
      View in: PubMed
    2. Taylor PH, Cinquin A, Cinquin O. Quantification of in vivo progenitor mutation accrual with ultra-low error rate and minimal input DNA using SIP-HAVA-seq. Genome Res. 2016 11; 26(11):1600-1611. PMID: 27803194.
      View in: PubMed
    3. Cinquin A, Chiang M, Paz A, Hallman S, Yuan O, Vysniauskaite I, Fowlkes CC, Cinquin O. Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line. PLoS Genet. 2016 Apr; 12(4):e1005985. PMID: 27077385.
      View in: PubMed
    4. Chiang M, Hallman S, Cinquin A, de Mochel NR, Paz A, Kawauchi S, Calof AL, Cho KW, Fowlkes CC, Cinquin O. Analysis of in vivo single cell behavior by high throughput, human-in-the-loop segmentation of three-dimensional images. BMC Bioinformatics. 2015 Nov 25; 16:397. PMID: 26607933.
      View in: PubMed
    5. Cinquin A, Zheng L, Taylor PH, Paz A, Zhang L, Chiang M, Snow JJ, Nie Q, Cinquin O. Semi-permeable Diffusion Barriers Enhance Patterning Robustness in the C. elegans Germline. Dev Cell. 2015 Nov 23; 35(4):405-17. PMID: 26609956.
      View in: PubMed
    6. Meeds E, Chiang M, Lee M, Cinquin O, Lowengrub J, Welling M. POPE: post optimization posterior evaluation of likelihood free models. BMC Bioinformatics. 2015 Aug 20; 16:264. PMID: 26289041.
      View in: PubMed
    7. Chiang M, Cinquin A, Paz A, Meeds E, Price CA, Welling M, Cinquin O. Control of Caenorhabditis elegans germ-line stem-cell cycling speed meets requirements of design to minimize mutation accumulation. BMC Biol. 2015 Jul 18; 13:51. PMID: 26187634.
      View in: PubMed
    8. Reyes de Mochel NS, Luong M, Chiang M, Javier AL, Luu E, Toshihiko F, MacGregor GR, Cinquin O, Cho KW. BMP signaling is required for cell cleavage in preimplantation-mouse embryos. Dev Biol. 2015 Jan 01; 397(1):45-55. PMID: 25446538.
      View in: PubMed
    9. Wong BG, Paz A, Corrado MA, Ramos BR, Cinquin A, Cinquin O, Hui EE. Live imaging reveals active infiltration of mitotic zone by its stem cell niche. Integr Biol (Camb). 2013 Jul 24; 5(7):976-82. PMID: 23695198.
      View in: PubMed
    10. Stringari C, Cinquin A, Cinquin O, Digman MA, Donovan PJ, Gratton E. Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13582-7. PMID: 21808026.
      View in: PubMed
    11. Cinquin O, Crittenden SL, Morgan DE, Kimble J. Progression from a stem cell-like state to early differentiation in the C. elegans germ line. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2048-53. PMID: 20080700.
      View in: PubMed
    12. Cinquin O. Purpose and regulation of stem cells: a systems-biology view from the Caenorhabditis elegans germ line. J Pathol. 2009 Jan; 217(2):186-98. PMID: 19065622.
      View in: PubMed
    13. Cinquin O. Understanding the somitogenesis clock: what's missing? Mech Dev. 2007 Aug; 124(7-8):501-17. PMID: 17643270.
      View in: PubMed
    14. Albazerchi A, Cinquin O, Stern CD. A new method to transfect the hypoblast of the chick embryo reveals conservation of the regulation of an Otx2 enhancer between mouse and chick extraembryonic endoderm. BMC Dev Biol. 2007 Apr 02; 7:25. PMID: 17407554.
      View in: PubMed
    15. Cinquin O. Repressor dimerization in the zebrafish somitogenesis clock. PLoS Comput Biol. 2007 Feb 16; 3(2):e32. PMID: 17305423.
      View in: PubMed
    16. Cinquin O, Page KM. Generalized, switch-like competitive heterodimerization networks. Bull Math Biol. 2007 Feb; 69(2):483-94. PMID: 17216403.
      View in: PubMed
    17. Cinquin O. Fast-tracking morphogen diffusion. J Theor Biol. 2006 Feb 07; 238(3):532-40. PMID: 16095625.
      View in: PubMed
    18. Cinquin O, Demongeot J. High-dimensional switches and the modelling of cellular differentiation. J Theor Biol. 2005 Apr 07; 233(3):391-411. PMID: 15652148.
      View in: PubMed
    19. Christopherson RI, Cinquin O, Shojaei M, Kuehn D, Menz RI. Cloning and expression of malarial pyrimidine enzymes. Nucleosides Nucleotides Nucleic Acids. 2004 Oct; 23(8-9):1459-65. PMID: 15571277.
      View in: PubMed
    20. Cinquin O. Is the somitogenesis clock really cell-autonomous? A coupled-oscillator model of segmentation. J Theor Biol. 2003 Oct 21; 224(4):459-68. PMID: 12957118.
      View in: PubMed
    21. Cinquin O, Demongeot J. Roles of positive and negative feedback in biological systems. C R Biol. 2002 Nov; 325(11):1085-95. PMID: 12506722.
      View in: PubMed
    22. Menz RI, Cinquin O, Christopherson RI. The identification, cloning and functional expression of the gene encoding orotidine 5'-monophosphate (OMP) decarboxylase from Plasmodium falciparum. Ann Trop Med Parasitol. 2002 Jul; 96(5):469-76. PMID: 12194707.
      View in: PubMed
    23. Cinquin O, Demongeot J. Positive and negative feedback: striking a balance between necessary antagonists. J Theor Biol. 2002 May 21; 216(2):229-41. PMID: 12079373.
      View in: PubMed
    24. Cinquin O, Christopherson RI, Menz RI. A hybrid plasmid for expression of toxic malarial proteins in Escherichia coli. Mol Biochem Parasitol. 2001 Oct; 117(2):245-7. PMID: 11606237.
      View in: PubMed