Robert A Edwards

Title(s)Clinical Professor, Pathology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8576
Emailredwards@uci.edu
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    Collapse Research 
    Collapse Research Activities and Funding
    Coordinated regulation of alternative pre-mRNA processing in colon cancer
    NIH R01CA177651May 1, 2014 - Oct 30, 2020
    Role: Co-Principal Investigator
    Protanoids, Colitis, and Colon Cancer in Gia2-KO mice
    NIH R21DK071591Sep 11, 2007 - Feb 28, 2010
    Role: Principal Investigator
    Chemokine Signaling and Colitis in Gia2 Deficient Mice
    NIH K08DK059816Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt. Commun Biol. 2020 08 19; 3(1):453. Habowski AN, Flesher JL, Bates JM, Tsai CF, Martin K, Zhao R, Ganesan AK, Edwards RA, Shi T, Wiley HS, Shi Y, Hertel KJ, Waterman ML. PMID: 32814826; PMCID: PMC7438495.
      View in: PubMed   Mentions: 10  Translation:AnimalsCells
    2. Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol. 2017 02 09; 13(2):912. Lee M, Chen GT, Puttock E, Wang K, Edwards RA, Waterman ML, Lowengrub J. PMID: 28183841; PMCID: PMC5327728.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    3. Microcins mediate competition among Enterobacteriaceae in the inflamed gut. Nature. 2016 12 08; 540(7632):280-283. Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA, Edwards RA, Raffatellu M. PMID: 27798599; PMCID: PMC5145735.
      View in: PubMed   Mentions: 155     Fields:    Translation:AnimalsCells
    4. Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab. 2016; 4:20. Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML. PMID: 27729975; PMCID: PMC5046889.
      View in: PubMed   Mentions: 32  
    5. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. PMID: 24825347; PMCID: PMC4194089.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimalsCells
    6. Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci. 2014 May 01; 127(Pt 9):2017-28. Welch-Reardon KM, Ehsan SM, Wang K, Wu N, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CC. PMID: 24554431; PMCID: PMC4004976.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    7. Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron. Cell Host Microbe. 2013 Jul 17; 14(1):26-37. Deriu E, Liu JZ, Pezeshki M, Edwards RA, Ochoa RJ, Contreras H, Libby SJ, Fang FC, Raffatellu M. PMID: 23870311; PMCID: PMC3752295.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    8. Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9897-902. Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P. PMID: 23716692; PMCID: PMC3683799.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    9. miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discov. 2012 Jun; 2(6):540-53. Jahid S, Sun J, Edwards RA, Dizon D, Panarelli NC, Milsom JW, Sikandar SS, Gümüs ZH, Lipkin SM. PMID: 22628407; PMCID: PMC3651884.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimals
    10. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe. 2012 Mar 15; 11(3):227-39. Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. PMID: 22423963; PMCID: PMC3308348.
      View in: PubMed   Mentions: 183     Fields:    Translation:AnimalsCells
    11. TNF-α induces upregulation of EGFR expression and signaling in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15; 302(8):G805-14. Yoo J, Rodriguez Perez CE, Nie W, Edwards RA, Sinnett-Smith J, Rozengurt E. PMID: 22301110; PMCID: PMC3355565.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    12. Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. J Immunol. 2011 Sep 01; 187(5):2677-87. Galitovskiy V, Qian J, Chernyavsky AI, Marchenko S, Gindi V, Edwards RA, Grando SA. PMID: 21784975; PMCID: PMC4260719.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    13. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res. 2010 Feb 15; 70(4):1469-78. Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. PMID: 20145124; PMCID: PMC4010106.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    14. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res. 2009 Aug 15; 69(16):6423-9. Edwards RA, Witherspoon M, Wang K, Afrasiabi K, Pham T, Birnbaumer L, Lipkin SM. PMID: 19638594; PMCID: PMC2748849.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    15. Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice. Inflamm Bowel Dis. 2008 Jul; 14(7):898-907. Edwards RA, Wang K, Davis JS, Birnbaumer L. PMID: 18340649; PMCID: PMC2729494.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    16. Laser capture microdissection of mammalian tissue. J Vis Exp. 2007; (8):309. Edwards RA. PMID: 18989416; PMCID: PMC2562492.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    17. Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1511-9. Hoang B, Trinh A, Birnbaumer L, Edwards RA. PMID: 17332478.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts. Inflamm Bowel Dis. 2006 Mar; 12(3):153-65. Edwards RA, Smock AZ. PMID: 16534415.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    19. Impaired TGF-beta responses in peripheral T cells of G alpha i2-/- mice. J Immunol. 2005 May 15; 174(10):6122-8. Wu JY, Jin Y, Edwards RA, Zhang Y, Finegold MJ, Wu MX. PMID: 15879107.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
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