Robert Edwards * UCI Profiles

Edwards, Robert A

Title(s)	Associate Clinical Professor, Pathology
Phone	(949) 824-8576
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Research

Research Activities and Funding

Coordinated regulation of alternative pre-mRNA processing in colon cancer
NIH/NCI R01CA177651May 1, 2014 - Apr 30, 2019
Role: Co-Principal Investigator

Protanoids, Colitis, and Colon Cancer in Gia2-KO mice
NIH/NIDDK R21DK071591Sep 11, 2007 - Feb 28, 2010
Role: Principal Investigator

Chemokine Signaling and Colitis in Gia2 Deficient Mice
NIH/NIDDK K08DK059816Sep 30, 2002 - Aug 31, 2007
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Lee M, Chen GT, Puttock E, Wang K, Edwards RA, Waterman ML, Lowengrub J. Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol. 2017 02 09; 13(2):912. PMID: 28183841.

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Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA, Edwards RA, Raffatellu M. Microcins mediate competition among Enterobacteriaceae in the inflamed gut. Nature. 2016 12 08; 540(7632):280-283. PMID: 27798599.

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Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML. Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab. 2016; 4:20. PMID: 27729975.

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Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. PMID: 24825347; PMCID: PMC4194089.

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Welch-Reardon KM, Ehsan SM, Wang K, Wu N, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CC. Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci. 2014 May 01; 127(Pt 9):2017-28. PMID: 24554431.

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Deriu E, Liu JZ, Pezeshki M, Edwards RA, Ochoa RJ, Contreras H, Libby SJ, Fang FC, Raffatellu M. Probiotic bacteria reduce salmonella typhimurium intestinal colonization by competing for iron. Cell Host Microbe. 2013 Jul 17; 14(1):26-37. PMID: 23870311; PMCID: PMC3752295.

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Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P. Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9897-902. PMID: 23716692; PMCID: PMC3683799.

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Jahid S, Sun J, Edwards RA, Dizon D, Panarelli NC, Milsom JW, Sikandar SS, Gümüs ZH, Lipkin SM. miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discov. 2012 Jun; 2(6):540-53. PMID: 22628407.

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Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe. 2012 Mar 15; 11(3):227-39. PMID: 22423963; PMCID: PMC3308348.

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Yoo J, Rodriguez Perez CE, Nie W, Edwards RA, Sinnett-Smith J, Rozengurt E. TNF-a induces upregulation of EGFR expression and signaling in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15; 302(8):G805-14. PMID: 22301110; PMCID: PMC3355565.

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Galitovskiy V, Qian J, Chernyavsky AI, Marchenko S, Gindi V, Edwards RA, Grando SA. Cytokine-induced alterations of a7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. J Immunol. 2011 Sep 01; 187(5):2677-87. PMID: 21784975.

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Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab. 2011 May 04; 13(5):540-9. PMID: 21531336; PMCID: PMC3090630.

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Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res. 2010 Feb 15; 70(4):1469-78. PMID: 20145124.

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Edwards RA, Witherspoon M, Wang K, Afrasiabi K, Pham T, Birnbaumer L, Lipkin SM. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res. 2009 Aug 15; 69(16):6423-9. PMID: 19638594.

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Edwards RA, Wang K, Davis JS, Birnbaumer L. Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice. Inflamm Bowel Dis. 2008 Jul; 14(7):898-907. PMID: 18340649.

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Edwards RA. Laser capture microdissection of mammalian tissue. J Vis Exp. 2007; (8):309. PMID: 18989416.

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Hoang B, Trinh A, Birnbaumer L, Edwards RA. Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1511-9. PMID: 17332478.

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Edwards RA, Smock AZ. Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts. Inflamm Bowel Dis. 2006 Mar; 12(3):153-65. PMID: 16534415.

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Wu JY, Jin Y, Edwards RA, Zhang Y, Finegold MJ, Wu MX. Impaired TGF-beta responses in peripheral T cells of G alpha i2-/- mice. J Immunol. 2005 May 15; 174(10):6122-8. PMID: 15879107.

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