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Edwards, Robert A

TitleAssociate Clinical Professor
InstitutionUniversity of California, Irvine
DepartmentPathology
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-8576
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    Collapse Research 
    Collapse Research Activities and Funding
    Coordinated regulation of alternative pre-mRNA processing in colon cancer
    NIH/NCI R01CA177651May 1, 2014 - Apr 30, 2019
    Role: Co-Principal Investigator
    Protanoids, Colitis, and Colon Cancer in Gia2-KO mice
    NIH/NIDDK R21DK071591Sep 11, 2007 - Feb 28, 2010
    Role: Principal Investigator
    Chemokine Signaling and Colitis in Gia2 Deficient Mice
    NIH/NIDDK K08DK059816Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee M, Chen GT, Puttock E, Wang K, Edwards RA, Waterman ML, Lowengrub J. Mathematical modeling links Wnt signaling to emergent patterns of metabolism in colon cancer. Mol Syst Biol. 2017 02 09; 13(2):912. PMID: 28183841.
      View in: PubMed
    2. Sprowl-Tanio S, Habowski AN, Pate KT, McQuade MM, Wang K, Edwards RA, Grun F, Lyou Y, Waterman ML. Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer. Cancer Metab. 2016; 4:20. PMID: 27729975.
      View in: PubMed
    3. Pate KT, Stringari C, Sprowl-Tanio S, Wang K, TeSlaa T, Hoverter NP, McQuade MM, Garner C, Digman MA, Teitell MA, Edwards RA, Gratton E, Waterman ML. Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer. EMBO J. 2014 Jul 01; 33(13):1454-73. PMID: 24825347; PMCID: PMC4194089.
    4. Welch-Reardon KM, Ehsan SM, Wang K, Wu N, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CC. Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci. 2014 May 01; 127(Pt 9):2017-28. PMID: 24554431; PMCID: PMC4004976.
    5. Bellet MM, Deriu E, Liu JZ, Grimaldi B, Blaschitz C, Zeller M, Edwards RA, Sahar S, Dandekar S, Baldi P, George MD, Raffatellu M, Sassone-Corsi P. Circadian clock regulates the host response to Salmonella. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9897-902. PMID: 23716692; PMCID: PMC3683799.
    6. Jahid S, Sun J, Edwards RA, Dizon D, Panarelli NC, Milsom JW, Sikandar SS, Gümüs ZH, Lipkin SM. miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discov. 2012 Jun; 2(6):540-53. PMID: 22628407; PMCID: PMC3651884.
    7. Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe. 2012 Mar 15; 11(3):227-39. PMID: 22423963; PMCID: PMC3308348.
    8. Yoo J, Rodriguez Perez CE, Nie W, Edwards RA, Sinnett-Smith J, Rozengurt E. TNF-a induces upregulation of EGFR expression and signaling in human colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15; 302(8):G805-14. PMID: 22301110; PMCID: PMC3355565.
    9. Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG, Raffatellu M, Osborne TF. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab. 2011 May 04; 13(5):540-9. PMID: 21531336; PMCID: PMC3090630.
    10. Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res. 2010 Feb 15; 70(4):1469-78. PMID: 20145124; PMCID: PMC4010106.
    11. Edwards RA, Witherspoon M, Wang K, Afrasiabi K, Pham T, Birnbaumer L, Lipkin SM. Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. Cancer Res. 2009 Aug 15; 69(16):6423-9. PMID: 19638594; PMCID: PMC2748849.
    12. Edwards RA, Wang K, Davis JS, Birnbaumer L. Role for epithelial dysregulation in early-onset colitis-associated colon cancer in Gi2-alpha-/- mice. Inflamm Bowel Dis. 2008 Jul; 14(7):898-907. PMID: 18340649.
      View in: PubMed
    13. Edwards RA. Laser capture microdissection of mammalian tissue. J Vis Exp. 2007; (8):309. PMID: 18989416; PMCID: PMC2562492.
    14. Hoang B, Trinh A, Birnbaumer L, Edwards RA. Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1511-9. PMID: 17332478.
      View in: PubMed
    15. Edwards RA, Smock AZ. Defective arachidonate release and PGE2 production in Gi alpha2-deficient intestinal and colonic subepithelial myofibroblasts. Inflamm Bowel Dis. 2006 Mar; 12(3):153-65. PMID: 16534415.
      View in: PubMed
    16. Wu JY, Jin Y, Edwards RA, Zhang Y, Finegold MJ, Wu MX. Impaired TGF-beta responses in peripheral T cells of G alpha i2-/- mice. J Immunol. 2005 May 15; 174(10):6122-8. PMID: 15879107.
      View in: PubMed