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Gershon, Paul David

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMolecular Biology & Biochem
Address1222 Natural Sciences 1
Zot 3900
CA 92697
Phone(949) 824-9606, 7954
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel nuclear and intracellular pathology in early AD
    NIH/NIA R21AG045729May 1, 2014 - Apr 30, 2016
    Role: Co-Principal Investigator
    The Pox Virion Molecular Interactome
    NIH/NIAID R21AI101577Sep 9, 2013 - Aug 31, 2015
    Role: Principal Investigator
    LTQ Velos Pro mass spectrometer with ETD and other options
    NIH S10OD016328Jul 1, 2013 - Jun 30, 2014
    Role: Principal Investigator
    MALDI TOF MASS SPECTROMETER
    NIH/NCRR S10RR015921Jun 1, 2001 - May 31, 2002
    Role: Principal Investigator
    Mechanism of Poly(a) Tail Formation by Vaccinia Virus
    NIH/NIGMS R01GM051953Aug 1, 1995 - Jul 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mirzakhanyan Y, Gershon P. Multisubunit DNA-Dependent RNA Polymerases from Vaccinia Virus and Other Nucleocytoplasmic Large-DNA Viruses: Impressions from the Age of Structure. Microbiol Mol Biol Rev. 2017 Sep; 81(3). PMID: 28701329.
      View in: PubMed
    2. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon P, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. PMID: 27914984.
      View in: PubMed
    3. Carpenter PM, Sivadas P, Hua SS, Xiao C, Gutierrez AB, Ngo T, Gershon P. Migration of breast cancer cell lines in response to pulmonary laminin 332. Cancer Med. 2017 Jan; 6(1):220-234. PMID: 27878981.
      View in: PubMed
    4. Ngo T, Mirzakhanyan Y, Moussatche N, Gershon P. Protein Primary Structure of the Vaccinia Virion at Increased Resolution J Virol. 2016 11 01; 90(21):9905-9919. PMID: 27558425.
      View in: PubMed
    5. Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon P, Botvinick EL, George SC, Hughes CC. Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tissue Eng Part A. 2016 08; 22(15-16):1016-25. PMID: 27392582; PMCID: PMC4991595 [Available on 08/01/17].
    6. Flather D, Cathcart AL, Cruz C, Baggs E, Ngo T, Gershon P, Semler BL. Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs. Viruses. 2016 Feb 04; 8(2). PMID: 26861382; PMCID: PMC4776194.
    7. Knopp KA, Ngo T, Gershon P, Buchmeier MJ. Single nucleoprotein residue modulates arenavirus replication complex formation. MBio. 2015 Apr 28; 6(3):e00524-15. PMID: 25922393; PMCID: PMC4436057.
    8. Marinotti O, Ngo T, Kojin BB, Chou SP, Nguyen B, Juhn J, Carballar-Lejarazú R, Marinotti PN, Jiang X, Walter MF, Tu Z, Gershon P, James AA. Integrated proteomic and transcriptomic analysis of the Aedes aegypti eggshell. BMC Dev Biol. 2014 Apr 05; 14:15. PMID: 24707823; PMCID: PMC4234484.
    9. Gershon P. Cleaved and missed sites for trypsin, lys-C, and lys-N can be predicted with high confidence on the basis of sequence context. J Proteome Res. 2014 Feb 07; 13(2):702-9. PMID: 24328144.
      View in: PubMed
    10. Li H, Li C, Zhou S, Poulos TL, Gershon P. Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid. Acta Crystallogr D Biol Crystallogr. 2013 Apr; 69(Pt 4):617-24. PMID: 23519670; PMCID: PMC3606039.
    11. Newman AC, Chou W, Welch-Reardon KM, Fong AH, Popson SA, Phan DT, Sandoval DR, Nguyen DP, Gershon P, Hughes CC. Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):513-22. PMID: 23288153; PMCID: PMC3638018.
    12. Rozovics JM, Chase AJ, Cathcart AL, Chou W, Gershon P, Palusa S, Wilusz J, Semler BL. Picornavirus modification of a host mRNA decay protein. MBio. 2012 Nov 06; 3(6):e00431-12. PMID: 23131833; PMCID: PMC3487778.
    13. Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon P, Semler BL. An RNA virus hijacks an incognito function of a DNA repair enzyme. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14634-9. PMID: 22908287; PMCID: PMC3437895.
    14. Chou W, Ngo T, Gershon P. An overview of the vaccinia virus infectome: a survey of the proteins of the poxvirus-infected cell. J Virol. 2012 Feb; 86(3):1487-99. PMID: 22090131; PMCID: PMC3264349.
    15. Newman AC, Nakatsu MN, Chou W, Gershon P, Hughes CC. The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Mol Biol Cell. 2011 Oct; 22(20):3791-800. PMID: 21865599; PMCID: PMC3192859.
    16. Gershon P. Two tools for applying chromatographic retention data to the mass-based identification of peptides during hydrogen/deuterium exchange experiments by nano-liquid chromatography/matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom. 2010 Dec 15; 24(23):3373-9. PMID: 21072792.
      View in: PubMed
    17. Amenya DA, Chou W, Li J, Yan G, Gershon P, James AA, Marinotti O. Proteomics reveals novel components of the Anopheles gambiae eggshell. J Insect Physiol. 2010 Oct; 56(10):1414-9. PMID: 20433845; PMCID: PMC2918668.
    18. Aphasizheva I, Ringpis GE, Weng J, Gershon P, Lathrop RH, Aphasizhev R. Novel TUTase associates with an editosome-like complex in mitochondria of Trypanosoma brucei. RNA. 2009 Jul; 15(7):1322-37. PMID: 19465686; PMCID: PMC2704088.
    19. Li C, Li H, Zhou S, Sun E, Yoshizawa J, Poulos TL, Gershon P. Polymerase translocation with respect to single-stranded nucleic acid: looping or wrapping of primer around a poly(A) polymerase. Structure. 2009 May 13; 17(5):680-9. PMID: 19446524.
      View in: PubMed
    20. Souki SK, Gershon P, Sandri-Goldin RM. Arginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replication. J Virol. 2009 Jun; 83(11):5309-20. PMID: 19321610; PMCID: PMC2681963.
    21. Etheridge RD, Clemens DM, Gershon P, Aphasizhev R. Identification and characterization of nuclear non-canonical poly(A) polymerases from Trypanosoma brucei. Mol Biochem Parasitol. 2009 Mar; 164(1):66-73. PMID: 19070634; PMCID: PMC2852512.
    22. Nikamanon P, Pun E, Chou W, Koter MD, Gershon P. "TOF2H": a precision toolbox for rapid, high density/high coverage hydrogen-deuterium exchange mass spectrometry via an LC-MALDI approach, covering the data pipeline from spectral acquisition to HDX rate analysis. BMC Bioinformatics. 2008 Sep 20; 9:387. PMID: 18803853; PMCID: PMC2561049.
    23. Etheridge RD, Aphasizheva I, Gershon P, Aphasizhev R. 3' adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria. EMBO J. 2008 Jun 04; 27(11):1596-608. PMID: 18464794; PMCID: PMC2426725.
    24. Yoshizawa JM, Li C, Gershon P. Saltatory forward movement of a poly(A) polymerase during poly(A) tail addition. J Biol Chem. 2007 Jun 29; 282(26):19144-51. PMID: 17488726.
      View in: PubMed
    25. Moure CM, Bowman BR, Gershon P, Quiocho FA. Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity. Mol Cell. 2006 May 05; 22(3):339-49. PMID: 16678106.
      View in: PubMed
    26. Gershon P. Studying vaccinia virus RNA processing in vitro. Methods Mol Biol. 2004; 269:151-68. PMID: 15114015.
      View in: PubMed
    27. Johnson L, Gershon P. Direct detection of protein thiol derivatization by PAGE. Biotechniques. 2002 Dec; 33(6):1292-5. PMID: 12503314.
      View in: PubMed
    28. Latner DR, Thompson JM, Gershon P, Storrs C, Condit RC. The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-2'-O-) methyltransferase and poly(A) polymerase stimulatory functions. Virology. 2002 Sep 15; 301(1):64-80. PMID: 12359447.
      View in: PubMed
    29. Hu G, Oguro A, Li C, Gershon P, Quiocho FA. The "cap-binding slot" of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap. Biochemistry. 2002 Jun 18; 41(24):7677-87. PMID: 12056899.
      View in: PubMed
    30. Oguro A, Johnson L, Gershon P. Path of an RNA ligand around the surface of the vaccinia VP39 subunit of its cognate VP39-VP55 protein heterodimer. Chem Biol. 2002 Jun; 9(6):679-90. PMID: 12079779.
      View in: PubMed
    31. Peng ZH, Sharma V, Singleton SF, Gershon P. Synthesis and application of a chain-terminating dinucleotide mRNA cap analog. Org Lett. 2002 Jan 24; 4(2):161-4. PMID: 11796040.
      View in: PubMed