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Gershon, Paul David

Title(s)Professor, Molecular Biology & Biochemistry
Phone(949) 824-9606, 7954
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    Collapse Research 
    Collapse Research Activities and Funding
    Novel nuclear and intracellular pathology in early AD
    NIH/NIA R21AG045729May 1, 2014 - Apr 30, 2016
    Role: Co-Principal Investigator
    The Pox Virion Molecular Interactome
    NIH/NIAID R21AI101577Sep 9, 2013 - Aug 31, 2015
    Role: Principal Investigator
    LTQ Velos Pro mass spectrometer with ETD and other options
    NIH S10OD016328Jul 1, 2013 - Jun 30, 2014
    Role: Principal Investigator
    MALDI TOF MASS SPECTROMETER
    NIH/NCRR S10RR015921Jun 1, 2001 - May 31, 2002
    Role: Principal Investigator
    Mechanism of Poly(a) Tail Formation by Vaccinia Virus
    NIH/NIGMS R01GM051953Aug 1, 1995 - Jul 31, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Sandoval R, Boyd RD, Kiszter AN, Mirzakhanyan Y, Santibanez P, Gershon PD, Hayes ML. Stable native RIP9 complexes associate with C-to-U RNA editing activity, PPRs, RIPs, OZ1, ORRM1 and ISE2. Plant J. 2019 May 11. PMID: 31077462.
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    2. Mirzakhanyan Y, Gershon P. The Vaccinia virion: Filling the gap between atomic and ultrastructure. PLoS Pathog. 2019 01; 15(1):e1007508. PMID: 30615658.
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    3. Flather D, Nguyen JHC, Semler BL, Gershon PD. Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus. PLoS Pathog. 2018 08; 14(8):e1007277. PMID: 30142213.
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    4. Mirzakhanyan Y, Gershon PD. Multisubunit DNA-Dependent RNA Polymerases from Vaccinia Virus and Other Nucleocytoplasmic Large-DNA Viruses: Impressions from the Age of Structure. Microbiol Mol Biol Rev. 2017 09; 81(3). PMID: 28701329.
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    5. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. PMID: 27914984.
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    6. Carpenter PM, Sivadas P, Hua SS, Xiao C, Gutierrez AB, Ngo T, Gershon PD. Migration of breast cancer cell lines in response to pulmonary laminin 332. Cancer Med. 2017 01; 6(1):220-234. PMID: 27878981.
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    7. Ngo T, Mirzakhanyan Y, Moussatche N, Gershon PD. Protein Primary Structure of the Vaccinia Virion at Increased Resolution J Virol. 2016 11 01; 90(21):9905-9919. PMID: 27558425.
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    8. Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC. Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tissue Eng Part A. 2016 08; 22(15-16):1016-25. PMID: 27392582.
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    9. Flather D, Cathcart AL, Cruz C, Baggs E, Ngo T, Gershon PD, Semler BL. Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs. Viruses. 2016 Feb 04; 8(2). PMID: 26861382.
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    10. Knopp KA, Ngo T, Gershon PD, Buchmeier MJ. Single nucleoprotein residue modulates arenavirus replication complex formation. MBio. 2015 Apr 28; 6(3):e00524-15. PMID: 25922393; PMCID: PMC4436057.
    11. Marinotti O, Ngo T, Kojin BB, Chou SP, Nguyen B, Juhn J, Carballar-Lejarazú R, Marinotti PN, Jiang X, Walter MF, Tu Z, Gershon PD, James AA. Integrated proteomic and transcriptomic analysis of the Aedes aegypti eggshell. BMC Dev Biol. 2014 Apr 05; 14:15. PMID: 24707823.
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    12. Matson J, Chou W, Ngo T, Gershon PD. Static and dynamic protein phosphorylation in the Vaccinia virion. Virology. 2014 Mar; 452-453:310-23. PMID: 24606709.
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    13. Gershon PD. Cleaved and missed sites for trypsin, lys-C, and lys-N can be predicted with high confidence on the basis of sequence context. J Proteome Res. 2014 Feb 07; 13(2):702-9. PMID: 24328144.
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    14. Li H, Li C, Zhou S, Poulos TL, Gershon PD. Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid. Acta Crystallogr D Biol Crystallogr. 2013 Apr; 69(Pt 4):617-24. PMID: 23519670.
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    15. Newman AC, Chou W, Welch-Reardon KM, Fong AH, Popson SA, Phan DT, Sandoval DR, Nguyen DP, Gershon PD, Hughes CC. Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):513-22. PMID: 23288153.
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    16. Rozovics JM, Chase AJ, Cathcart AL, Chou W, Gershon PD, Palusa S, Wilusz J, Semler BL. Picornavirus modification of a host mRNA decay protein. MBio. 2012 Nov 06; 3(6):e00431-12. PMID: 23131833.
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    17. Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon PD, Semler BL. An RNA virus hijacks an incognito function of a DNA repair enzyme. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14634-9. PMID: 22908287.
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    18. Chou W, Ngo T, Gershon PD. An overview of the vaccinia virus infectome: a survey of the proteins of the poxvirus-infected cell. J Virol. 2012 Feb; 86(3):1487-99. PMID: 22090131.
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    19. Newman AC, Nakatsu MN, Chou W, Gershon PD, Hughes CC. The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Mol Biol Cell. 2011 Oct; 22(20):3791-800. PMID: 21865599.
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    20. Gershon PD. Two tools for applying chromatographic retention data to the mass-based identification of peptides during hydrogen/deuterium exchange experiments by nano-liquid chromatography/matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom. 2010 Dec 15; 24(23):3373-9. PMID: 21072792.
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    21. Li CZ, Koter M, Ye X, Zhou SF, Chou W, Luo R, Gershon PD. Widespread but small-scale changes in the structural and dynamic properties of vaccinia virus poly(A) polymerase upon association with its processivity factor in solution. Biochemistry. 2010 Jul 27; 49(29):6247-62. PMID: 20469877.
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    22. Amenya DA, Chou W, Li J, Yan G, Gershon PD, James AA, Marinotti O. Proteomics reveals novel components of the Anopheles gambiae eggshell. J Insect Physiol. 2010 Oct; 56(10):1414-9. PMID: 20433845.
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    23. Aphasizheva I, Ringpis GE, Weng J, Gershon PD, Lathrop RH, Aphasizhev R. Novel TUTase associates with an editosome-like complex in mitochondria of Trypanosoma brucei. RNA. 2009 Jul; 15(7):1322-37. PMID: 19465686.
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    24. Li C, Li H, Zhou S, Sun E, Yoshizawa J, Poulos TL, Gershon PD. Polymerase translocation with respect to single-stranded nucleic acid: looping or wrapping of primer around a poly(A) polymerase. Structure. 2009 May 13; 17(5):680-9. PMID: 19446524.
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    25. Souki SK, Gershon PD, Sandri-Goldin RM. Arginine methylation of the ICP27 RGG box regulates ICP27 export and is required for efficient herpes simplex virus 1 replication. J Virol. 2009 Jun; 83(11):5309-20. PMID: 19321610.
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    26. Etheridge RD, Clemens DM, Gershon PD, Aphasizhev R. Identification and characterization of nuclear non-canonical poly(A) polymerases from Trypanosoma brucei. Mol Biochem Parasitol. 2009 Mar; 164(1):66-73. PMID: 19070634; PMCID: PMC2852512.
    27. Nikamanon P, Pun E, Chou W, Koter MD, Gershon PD. "TOF2H": a precision toolbox for rapid, high density/high coverage hydrogen-deuterium exchange mass spectrometry via an LC-MALDI approach, covering the data pipeline from spectral acquisition to HDX rate analysis. BMC Bioinformatics. 2008 Sep 20; 9:387. PMID: 18803853.
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    28. Kuznetsov Y, Gershon PD, McPherson A. Atomic force microscopy investigation of vaccinia virus structure. J Virol. 2008 Aug; 82(15):7551-66. PMID: 18508898.
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    29. Etheridge RD, Aphasizheva I, Gershon PD, Aphasizhev R. 3' adenylation determines mRNA abundance and monitors completion of RNA editing in T. brucei mitochondria. EMBO J. 2008 Jun 04; 27(11):1596-608. PMID: 18464794.
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    30. Yoshizawa JM, Li C, Gershon PD. Saltatory forward movement of a poly(A) polymerase during poly(A) tail addition. J Biol Chem. 2007 Jun 29; 282(26):19144-51. PMID: 17488726.
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    31. Moure CM, Bowman BR, Gershon PD, Quiocho FA. Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity. Mol Cell. 2006 May 05; 22(3):339-49. PMID: 16678106.
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    32. Li C, Gershon PD. pKa of the mRNA cap-specific 2'-O-methyltransferase catalytic lysine by HSQC NMR detection of a two-carbon probe. Biochemistry. 2006 Jan 24; 45(3):907-17. PMID: 16411767.
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    33. Li C, Xia Y, Gao X, Gershon PD. Mechanism of RNA 2'-O-methylation: evidence that the catalytic lysine acts to steer rather than deprotonate the target nucleophile. Biochemistry. 2004 May 18; 43(19):5680-7. PMID: 15134442.
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    34. Johnson L, Liu S, Gershon PD. Molecular flexibility and discontinuous translocation of a non-templated polymerase. J Mol Biol. 2004 Apr 02; 337(4):843-56. PMID: 15033355.
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    35. Gershon PD. Studying vaccinia virus RNA processing in vitro. Methods Mol Biol. 2004; 269:151-68. PMID: 15114015.
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    36. Malkin AJ, McPherson A, Gershon PD. Structure of intracellular mature vaccinia virus visualized by in situ atomic force microscopy. J Virol. 2003 Jun; 77(11):6332-40. PMID: 12743290.
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    37. Johnson L, Gershon PD. Direct detection of protein thiol derivatization by PAGE. Biotechniques. 2002 Dec; 33(6):1292-5. PMID: 12503314.
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    38. Latner DR, Thompson JM, Gershon PD, Storrs C, Condit RC. The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-2'-O-) methyltransferase and poly(A) polymerase stimulatory functions. Virology. 2002 Sep 15; 301(1):64-80. PMID: 12359447.
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    39. Hu G, Oguro A, Li C, Gershon PD, Quiocho FA. The "cap-binding slot" of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap. Biochemistry. 2002 Jun 18; 41(24):7677-87. PMID: 12056899.
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    40. Oguro A, Johnson L, Gershon PD. Path of an RNA ligand around the surface of the vaccinia VP39 subunit of its cognate VP39-VP55 protein heterodimer. Chem Biol. 2002 Jun; 9(6):679-90. PMID: 12079779.
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    41. Peng ZH, Sharma V, Singleton SF, Gershon PD. Synthesis and application of a chain-terminating dinucleotide mRNA cap analog. Org Lett. 2002 Jan 24; 4(2):161-4. PMID: 11796040.
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    42. Collisson EW, Zhou M, Gershon P, Jayaram J. Infectious bronchitis virus nucleocapsid protein interactions with the 3' untranslated region of genomic RNA depend on uridylate bases. Adv Exp Med Biol. 2001; 494:669-75. PMID: 11774543.
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    43. Quiocho FA, Hu G, Gershon PD. Structural basis of mRNA cap recognition by proteins. Curr Opin Struct Biol. 2000 Feb; 10(1):78-86. PMID: 10679461.
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    44. Johnson L, Gershon PD. RNA binding characteristics and overall topology of the vaccinia poly(A) polymerase-processivity factor-primer complex. Nucleic Acids Res. 1999 Jul 01; 27(13):2708-21. PMID: 10373588.
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    45. Hu G, Gershon PD, Hodel AE, Quiocho FA. mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7149-54. PMID: 10377383.
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    46. Deng L, Johnson L, Neveu JM, Hardin S, Wang SM, Lane WS, Gershon PD. A polyadenylylation-specific RNA-contact site on the surface of the bifunctional vaccinia virus RNA modifying protein VP39 that is distinct from the mRNA 5' end-binding "cleft". J Mol Biol. 1999 Jan 29; 285(4):1417-27. PMID: 9917386.
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    47. Gershon PD, Shi X, Hodel AE. Evidence that the RNA methylation and poly(A) polymerase stimulatory activities of vaccinia virus protein VP39 do not impinge upon one another. Virology. 1998 Jul 05; 246(2):253-65. PMID: 9657944.
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    48. Kuge H, Brownlee GG, Gershon PD, Richter JD. Cap ribose methylation of c-mos mRNA stimulates translation and oocyte maturation in Xenopus laevis. Nucleic Acids Res. 1998 Jul 01; 26(13):3208-14. PMID: 9628920.
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    49. Lockless SW, Cheng HT, Hodel AE, Quiocho FA, Gershon PD. Recognition of capped RNA substrates by VP39, the vaccinia virus-encoded mRNA cap-specific 2'-O-methyltransferase. Biochemistry. 1998 Jun 09; 37(23):8564-74. PMID: 9622508.
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    50. Hodel AE, Gershon PD, Quiocho FA. Structural basis for sequence-nonspecific recognition of 5'-capped mRNA by a cap-modifying enzyme. Mol Cell. 1998 Feb; 1(3):443-7. PMID: 9660928.
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    51. Deng L, Beigelman L, Matulic-Adamic J, Karpeisky A, Gershon PD. Specific recognition of an rU2-N15-rU motif by VP55, the vaccinia virus poly(A) polymerase catalytic subunit. J Biol Chem. 1997 Dec 12; 272(50):31542-52. PMID: 9395491.
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    52. Shi X, Bernhardt TG, Wang SM, Gershon PD. The surface region of the bifunctional vaccinia RNA modifying protein VP39 that interfaces with Poly(A) polymerase is remote from the RNA binding cleft used for its mRNA 5' cap methylation function. J Biol Chem. 1997 Sep 12; 272(37):23292-302. PMID: 9287339.
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    53. Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA. Specific protein recognition of an mRNA cap through its alkylated base. Nat Struct Biol. 1997 May; 4(5):350-4. PMID: 9145102.
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    54. Deng L, Gershon PD. Interplay of two uridylate-specific RNA binding sites in the translocation of poly(A) polymerase from vaccinia virus. EMBO J. 1997 Mar 03; 16(5):1103-13. PMID: 9118948.
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    55. Hodel AE, Gershon PD, Shi X, Quiocho FA. The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends. Cell. 1996 Apr 19; 85(2):247-56. PMID: 8612277.
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    56. Gershon P, Moss B. Expression, purification, and characterization of vaccinia virus-encoded RNA and poly(A) polymerases. Methods Enzymol. 1996; 275:208-27. PMID: 9026640.
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    57. Shi X, Yao P, Jose T, Gershon P. Methyltransferase-specific domains within VP-39, a bifunctional protein that participates in the modification of both mRNA ends. RNA. 1996 Jan; 2(1):88-101. PMID: 8846300.
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    58. Thomson JG, Gershon PD. Use of vaccinia virus poly(A) polymerase for RNA 3'-end labeling with a chain-terminating nucleotide or a short 3' homopolymer tract. Biotechniques. 1995 Sep; 19(3):416-20, 422-5. PMID: 7495555.
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    59. Gershon PD, Khilko S. Stable chelating linkage for reversible immobilization of oligohistidine tagged proteins in the BIAcore surface plasmon resonance detector. J Immunol Methods. 1995 Jun 14; 183(1):65-76. PMID: 7602140.
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    60. Cao JX, Gershon PD, Black DN. Sequence analysis of HindIII Q2 fragment of capripoxvirus reveals a putative gene encoding a G-protein-coupled chemokine receptor homologue. Virology. 1995 May 10; 209(1):207-12. PMID: 7747471.
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    61. Schnierle BS, Gershon PD, Moss B. Mutational analysis of a multifunctional protein, with mRNA 5' cap-specific (nucleoside-2'-O-)-methyltransferase and 3'-adenylyltransferase stimulatory activities, encoded by vaccinia virus. J Biol Chem. 1994 Aug 12; 269(32):20700-6. PMID: 8051170.
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    62. Ahn BY, Gershon PD, Moss B. RNA polymerase-associated protein Rap94 confers promoter specificity for initiating transcription of vaccinia virus early stage genes. J Biol Chem. 1994 Mar 11; 269(10):7552-7. PMID: 8125977.
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    63. Gershon PD, Moss B. Uridylate-containing RNA sequences determine specificity for binding and polyadenylation by the catalytic subunit of vaccinia virus poly(A) polymerase. EMBO J. 1993 Dec; 12(12):4705-14. PMID: 7693457.
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    64. Gershon PD, Moss B. Stimulation of poly(A) tail elongation by the VP39 subunit of the vaccinia virus-encoded poly(A) polymerase. J Biol Chem. 1993 Jan 25; 268(3):2203-10. PMID: 8420988.
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    65. Gershon PD, Moss B. Transition from rapid processive to slow nonprocessive polyadenylation by vaccinia virus poly(A) polymerase catalytic subunit is regulated by the net length of the poly(A) tail. Genes Dev. 1992 Aug; 6(8):1575-86. PMID: 1353739.
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    66. Schnierle BS, Gershon PD, Moss B. Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2897-901. PMID: 1313572.
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    67. Gershon PD, Ahn BY, Garfield M, Moss B. Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus. Cell. 1991 Sep 20; 66(6):1269-78. PMID: 1670500.
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    68. Moss B, Ahn BY, Amegadzie B, Gershon PD, Keck JG. Cytoplasmic transcription system encoded by vaccinia virus. J Biol Chem. 1991 Jan 25; 266(3):1355-8. PMID: 1988424.
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    69. Ahn BY, Gershon PD, Jones EV, Moss B. Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor. Mol Cell Biol. 1990 Oct; 10(10):5433-41. PMID: 2398897.
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    70. Gershon PD, Moss B. Early transcription factor subunits are encoded by vaccinia virus late genes. Proc Natl Acad Sci U S A. 1990 Jun; 87(11):4401-5. PMID: 2190222.
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    71. Gershon PD, Ansell DM, Black DN. A comparison of the genome organization of capripoxvirus with that of the orthopoxviruses. J Virol. 1989 Nov; 63(11):4703-8. PMID: 2795717.
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    72. Gershon PD, Black DN. A capripoxvirus pseudogene whose only intact homologs are in other poxvirus genomes. Virology. 1989 Sep; 172(1):350-4. PMID: 2773324.
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    73. Gershon PD, Black DN. The nucleotide sequence around the capripoxvirus thymidine kinase gene reveals a gene shared specifically with leporipoxvirus. J Gen Virol. 1989 Mar; 70 ( Pt 3):525-33. PMID: 2732700.
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    74. Gershon PD, Black DN. A comparison of the genomes of capripoxvirus isolates of sheep, goats, and cattle. Virology. 1988 Jun; 164(2):341-9. PMID: 2835855.
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    75. Gershon PD, Black DN. Physical characterization of the genome of a cattle isolate of capripoxvirus. Virology. 1987 Oct; 160(2):473-6. PMID: 2821685.
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    76. Gershon PD, Howells RE. Mitochondrial protein synthesis in Plasmodium falciparum. Mol Biochem Parasitol. 1986 Jan; 18(1):37-43. PMID: 3515175.
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