Christopher C. Hughes

Title(s)Professor and Associate Dean for Research and Innovation, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address2400 Biological Sciences III
Zot 3900
Irvine CA 92697
Phone(949) 824-8771, 8143, 3379
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    A Vascularized Micro-Organ platform for the study of Brain-BBB-Blood interaction
    NIH R61HL154307Sep 3, 2020 - Aug 31, 2022
    Role: Principal Investigator
    A 3D vascularized islet biomimetic to model type 1 diabetes
    NIH UG3DK122639Aug 1, 2019 - Jul 31, 2024
    Role: Co-Principal Investigator
    A 3D vascularized islet biomimetic to model type 1 diabetes
    NIH UH3DK122639Aug 1, 2019 - Jul 31, 2024
    Role: Co-Principal Investigator
    Modular monitoring of hormone release from human islets
    NIH UC4DK116283Sep 15, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Microphysiological systems to model vascular malformations
    NIH UH3HL141799Sep 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Microphysiological systems to model vascular malformations
    NIH UG3HL141799Sep 1, 2017 - Jul 31, 2019
    Role: Principal Investigator
    Real-time bioluminescent detection of circulating biomarkers
    NIH R21EB022704Aug 15, 2016 - May 31, 2019
    Role: Principal Investigator
    A 3-D biomimetic human islet to model beta cell function in health and disease
    NIH UC4DK104202Sep 20, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    (PQD5) Development of in Vitro Vascularized Microtumors for Drug Screening
    NIH R01CA180122Aug 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Training Program in Cardiovascular Applied Research and Entrepreneurship
    NIH T32HL116270Jun 1, 2013 - May 31, 2023
    Role: Principal Investigator
    A 3-D In Vitro Platform of Tumor Metastasis (PQ24)
    NIH R01CA170879Aug 20, 2012 - Jun 30, 2017
    Role: Co-Principal Investigator
    Encapsulated engineered microtumors: A platform for high throughput drug screenin
    NIH R21CA154187Jan 1, 2011 - Dec 31, 2013
    Role: Principal Investigator
    Creating a prevascularized thick implantable human tissue
    NIH R21HL104203Jun 1, 2010 - Apr 30, 2013
    Role: Co-Principal Investigator
    Bidirectional Notch Signaling and Angiogenesis
    NIH R01HL086959Jan 19, 2007 - Dec 31, 2010
    Role: Principal Investigator
    Molecular Approaches targeted on blocking angiogenesis
    NIH R01HL060067Apr 1, 1999 - Feb 28, 2015
    Role: Principal Investigator
    Endothelial Cell Regulation of T Cell Activation
    NIH R01AI040710Jun 1, 1996 - Apr 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Port Wine Birthmark Therapy: A New Direction. Lasers Surg Med. 2024 Aug; 56(6):529-531. Messele F, Van Trigt W, Arkin L, Hughes CCW, Kelly KM. PMID: 39014561.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions. Res Sq. 2024 Jun 18. Hughes CCW, Fang J, Hatch C, Andrejecsk J, Trigt WV, Juat D, Chen YH, Matsumoto S, Lee A. PMID: 38947000; PMCID: PMC11213165.
      View in: PubMed   Mentions:
    3. Microphysiological systems as models for immunologically 'cold' tumors. Front Cell Dev Biol. 2024; 12:1389012. Gaebler D, Hachey SJ, Hughes CCW. PMID: 38711620; PMCID: PMC11070549.
      View in: PubMed   Mentions:
    4. SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system. Front Cardiovasc Med. 2024; 11:1360364. Hatch CJ, Piombo SD, Fang JS, Gach JS, Ewald ML, Van Trigt WK, Coon BG, Tong JM, Forthal DN, Hughes CCW. PMID: 38576426; PMCID: PMC10991679.
      View in: PubMed   Mentions: 3  
    5. A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions. bioRxiv. 2024 Mar 12. Fang JS, Hatch CJ, Andrejecsk J, Trigt WV, Juat DJ, Chen YH, Matsumoto S, Lee AP, Hughes CCW. PMID: 38559155; PMCID: PMC10979959.
      View in: PubMed   Mentions:
    6. A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction. Biofabrication. 2024 01 11; 16(2). Bender RHF, O'Donnell BT, Shergill B, Pham BQ, Tahmouresie S, Sanchez CN, Juat DJ, Hatch MMS, Shirure VS, Wortham M, Nguyen-Ngoc KV, Jun Y, Gaetani R, Christman KL, Teyton L, George SC, Sander M, Hughes CCW. PMID: 38128127; PMCID: PMC10782895.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model. Breast Cancer Res. 2024 01 05; 26(1):5. Hachey SJ, Hatch CJ, Gaebler D, Mocherla A, Nee K, Kessenbrock K, Hughes CCW. PMID: 38183074; PMCID: PMC10768273.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    8. Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research. J Vis Exp. 2023 09 15; (199). Hachey SJ, Gaebler D, Hughes CCW. PMID: 37782104; PMCID: PMC11050739.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls. Ann Surg Oncol. 2023 Jun; 30(6):3833-3844. Vallejos PA, Gonda A, Yu J, Sullivan BG, Ostowari A, Kwong ML, Choi A, Selleck MJ, Kabagwira J, Fuller RN, Gironda DJ, Levine EA, Hughes CCW, Wall NR, Miller LD, Senthil M. PMID: 36864326; PMCID: PMC10175396.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. Exosomes as a Source of Biomarkers for Gastrointestinal Cancers. Cancers (Basel). 2023 Feb 16; 15(4). Yu J, Ostowari A, Gonda A, Mashayekhi K, Dayyani F, Hughes CCW, Senthil M. PMID: 36831603; PMCID: PMC9954462.
      View in: PubMed   Mentions: 3  
    11. A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease. Transl Res. 2023 05; 255:97-108. Hachey SJ, Sobrino A, Lee JG, Jafari MD, Klempner SJ, Puttock EJ, Edwards RA, Lowengrub JS, Waterman ML, Zell JA, Hughes CCW. PMID: 36481562; PMCID: PMC10593408.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    12. Organotypic stromal cells impact endothelial cell transcriptome in 3D microvessel networks. Sci Rep. 2022 11 28; 12(1):20434. Curtis MB, Kelly N, Hughes CCW, George SC. PMID: 36443378; PMCID: PMC9705391.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    13. GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current models. Front Hum Neurosci. 2022; 16:1006027. Van Trigt WK, Kelly KM, Hughes CCW. PMID: 36405075; PMCID: PMC9670321.
      View in: PubMed   Mentions: 5  
    14. Deconstructing Allograft Adipose and Fascia Matrix: Fascia Matrix Improves Angiogenesis, Volume Retention, and Adipogenesis in a Rodent Model. Plast Reconstr Surg. 2023 01 01; 151(1):108-117. Ziegler ME, Sorensen AM, Banyard DA, Sayadi LR, Chnari E, Hatch MM, Tassey J, Mirzakhanyan Y, Gershon PD, Hughes CCW, Evans GRD, Widgerow AD. PMID: 36219861; PMCID: PMC10081826.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    15. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022 Apr 26; 39(4):110760. Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. PMID: 35476990; PMCID: PMC9128537.
      View in: PubMed   Mentions: 1     Fields:    
    16. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022 04 05; 39(1):110641. Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. PMID: 35385746; PMCID: PMC9127750.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    17. Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review. Oncologist. 2022 03 11; 27(3):210-219. Juat DJ, Hachey SJ, Billimek J, Del Rosario MP, Nelson EL, Hughes CCW, Zell JA. PMID: 35274719; PMCID: PMC8914488.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Regulation of Partial and Reversible Endothelial-to-Mesenchymal Transition in Angiogenesis. Front Cell Dev Biol. 2021; 9:702021. Fang JS, Hultgren NW, Hughes CCW. PMID: 34692672; PMCID: PMC8529039.
      View in: PubMed   Mentions: 12  
    19. Correction: The vascular niche in next generation microphysiological systems. Lab Chip. 2021 Sep 14; 21(18):3615-3616. Ewald ML, Chen YH, Lee AP, Hughes CCW. PMID: 34472547.
      View in: PubMed   Mentions: 2     Fields:    
    20. The vascular niche in next generation microphysiological systems. Lab Chip. 2021 09 07; 21(17):3244-3262. Ewald ML, Chen YH, Lee AP, Hughes CCW. PMID: 34396383; PMCID: PMC8635227.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    21. Tumor-on-chip modeling of organ-specific cancer and metastasis. Adv Drug Deliv Rev. 2021 08; 175:113798. Del Piccolo N, Shirure VS, Bi Y, Goedegebuure SP, Gholami S, Hughes CCW, Fields RC, George SC. PMID: 34015419.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    22. Engineering Vascularized Organoid-on-a-Chip Models. Annu Rev Biomed Eng. 2021 07 13; 23:141-167. Shirure VS, Hughes CCW, George SC. PMID: 33756087.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    23. An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Lab Chip. 2021 04 07; 21(7):1333-1351. Hachey SJ, Movsesyan S, Nguyen QH, Burton-Sojo G, Tankazyan A, Wu J, Hoang T, Zhao D, Wang S, Hatch MM, Celaya E, Gomez S, Chen GT, Davis RT, Nee K, Pervolarakis N, Lawson DA, Kessenbrock K, Lee AP, Lowengrub J, Waterman ML, Hughes CCW. PMID: 33605955; PMCID: PMC8525497.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    24. A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks. Microsyst Nanoeng. 2021; 7:4. Yue T, Zhao D, Phan DTT, Wang X, Park JJ, Biviji Z, Hughes CCW, Lee AP. PMID: 33456784; PMCID: PMC7787972.
      View in: PubMed   Mentions: 17  
    25. Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. Nat Commun. 2020 10 26; 11(1):5400. Hultgren NW, Fang JS, Ziegler ME, Ramirez RN, Phan DTT, Hatch MMS, Welch-Reardon KM, Paniagua AE, Kim LS, Shon NN, Williams DS, Mortazavi A, Hughes CCW. PMID: 33106502; PMCID: PMC7588439.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    26. Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs. Toxicology. 2020 12 01; 445:152601. Liu Y, Sakolish C, Chen Z, Phan DTT, Bender RHF, Hughes CCW, Rusyn I. PMID: 32980478; PMCID: PMC7606810.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    27. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem Cell Reports. 2019 03 05; 12(3):451-460. Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. PMID: 30745035; PMCID: PMC6409424.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    28. Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Schöenbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. PMID: 30398401; PMCID: PMC6306687.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    29. Applications of tumor chip technology. Lab Chip. 2018 09 26; 18(19):2893-2912. Hachey SJ, Hughes CCW. PMID: 30156248; PMCID: PMC6207449.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    30. Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia. Angiogenesis. 2019 02; 22(1):145-155. Faughnan ME, Gossage JR, Chakinala MM, Oh SP, Kasthuri R, Hughes CCW, McWilliams JP, Parambil JG, Vozoris N, Donaldson J, Paul G, Berry P, Sprecher DL. PMID: 30191360; PMCID: PMC6510884.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCTClinical Trials
    31. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. PMID: 29766399; PMCID: PMC6237663.
      View in: PubMed   Mentions: 281     Fields:    Translation:HumansAnimals
    32. A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function. Lab Chip. 2018 07 24; 18(15):2167-2177. Wang X, Zhao D, Phan DTT, Liu J, Chen X, Yang B, Hughes CCW, Zhang W, Lee AP. PMID: 29931005; PMCID: PMC6057814.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    33. Multiscale modeling of glioblastoma. Transl Cancer Res. 2018 Feb; 7(Suppl 1):S96-S98. Yan H, Romero-López M, Benitez LI, Di K, Frieboes HB, Hughes CCW, Bota DA, Lowengrub JS. PMID: 30211018; PMCID: PMC6130886.
      View in: PubMed   Mentions:
    34. Executive summary of the 12th HHT international scientific conference. Angiogenesis. 2018 02; 21(1):169-181. Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ. PMID: 29147802.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    35. 3D Mathematical Modeling of Glioblastoma Suggests That Transdifferentiated Vascular Endothelial Cells Mediate Resistance to Current Standard-of-Care Therapy. Cancer Res. 2017 08 01; 77(15):4171-4184. Yan H, Romero-López M, Benitez LI, Di K, Frieboes HB, Hughes CCW, Bota DA, Lowengrub JS. PMID: 28536277; PMCID: PMC5540807.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    36. Blood-brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood-central nervous system interface. Exp Biol Med (Maywood). 2017 11; 242(17):1669-1678. Phan DT, Bender RHF, Andrejecsk JW, Sobrino A, Hachey SJ, George SC, Hughes CC. PMID: 28195514; PMCID: PMC5786363.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    37. A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. Lab Chip. 2017 01 31; 17(3):511-520. Phan DTT, Wang X, Craver BM, Sobrino A, Zhao D, Chen JC, Lee LYN, George SC, Lee AP, Hughes CCW. PMID: 28092382; PMCID: PMC6995340.
      View in: PubMed   Mentions: 124     Fields:    Translation:Humans
    38. 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels. Methods Mol Biol. 2017; 1612:325-344. Wang X, Phan DTT, George SC, Hughes CCW, Lee AP. PMID: 28634954; PMCID: PMC7838062.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    39. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. PMID: 27914984; PMCID: PMC5226635.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    40. Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng. 2017 03; 64(3):538-548. Yan H, Romero-Lopez M, Frieboes HB, Hughes CC, Lowengrub JS. PMID: 27723576; PMCID: PMC5501302.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    41. 3D microtumors in vitro supported by perfused vascular networks. Sci Rep. 2016 08 23; 6:31589. Sobrino A, Phan DT, Datta R, Wang X, Hachey SJ, Romero-López M, Gratton E, Lee AP, George SC, Hughes CC. PMID: 27549930; PMCID: PMC4994029.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansCells
    42. Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tissue Eng Part A. 2016 08; 22(15-16):1016-25. Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC. PMID: 27392582; PMCID: PMC4991595.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    43. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 2016 10 01; 43:122-138. Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA. PMID: 27475528; PMCID: PMC5386322.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    44. Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cancers. Breast Cancer Res. 2016 05 11; 18(1):50. Gray MJ, Gong J, Hatch MM, Nguyen V, Hughes CC, Hutchins JT, Freimark BD. PMID: 27169467; PMCID: PMC4864933.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    45. mTORC2 mediates CXCL12-induced angiogenesis. Angiogenesis. 2016 07; 19(3):359-71. Ziegler ME, Hatch MM, Wu N, Muawad SA, Hughes CC. PMID: 27106789; PMCID: PMC4959910.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    46. Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma. Cancer Immunol Res. 2016 06; 4(6):531-40. Freimark BD, Gong J, Ye D, Gray MJ, Nguyen V, Yin S, Hatch MM, Hughes CC, Schroit AJ, Hutchins JT, Brekken RA, Huang X. PMID: 27045021; PMCID: PMC7821912.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    47. An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms. Lab Chip. 2016 Mar 07; 16(5):868-876. Wang X, Phan DTT, Zhao D, George SC, Hughes CCW, Lee AP. PMID: 26879519; PMCID: PMC4911208.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    48. Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels. Lab Chip. 2016 Jan 21; 16(2):282-90. Wang X, Phan DT, Sobrino A, George SC, Hughes CC, Lee AP. PMID: 26616908; PMCID: PMC4869859.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansCells
    49. Executive summary of the 11th HHT international scientific conference. Angiogenesis. 2015 Oct; 18(4):511-24. Arthur H, Geisthoff U, Gossage JR, Hughes CC, Lacombe P, Meek ME, Oh P, Roman BL, Trerotola SO, Velthuis S, Wooderchak-Donahue W. PMID: 26391603.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    50. A role for partial endothelial-mesenchymal transitions in angiogenesis? Arterioscler Thromb Vasc Biol. 2015 Feb; 35(2):303-8. Welch-Reardon KM, Wu N, Hughes CC. PMID: 25425619; PMCID: PMC4911209.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    51. Implanted cell-dense prevascularized tissues develop functional vasculature that supports reoxygenation after thrombosis. Tissue Eng Part A. 2014 Sep; 20(17-18):2316-28. White SM, Pittman CR, Hingorani R, Arora R, Esipova TV, Vinogradov SA, Hughes CC, Choi B, George SC. PMID: 24593148; PMCID: PMC4161156.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    52. A three-dimensional in vitro model of tumor cell intravasation. Integr Biol (Camb). 2014 Jun; 6(6):603-10. Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC. PMID: 24763498; PMCID: PMC4046910.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    53. A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening. Exp Biol Med (Maywood). 2014 Sep; 239(9):1240-54. Heylman C, Sobrino A, Shirure VS, Hughes CC, George SC. PMID: 24740872; PMCID: PMC4156538.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    54. Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1011-9. Popson SA, Ziegler ME, Chen X, Holderfield MT, Shaaban CI, Fong AH, Welch-Reardon KM, Papkoff J, Hughes CC. PMID: 24603679; PMCID: PMC3993998.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    55. Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci. 2014 May 01; 127(Pt 9):2017-28. Welch-Reardon KM, Ehsan SM, Wang K, Wu N, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CC. PMID: 24554431; PMCID: PMC4004976.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    56. A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. Lab Chip. 2013 Aug 07; 13(15):2990-8. Hsu YH, Moya ML, Hughes CC, George SC, Lee AP. PMID: 23723013; PMCID: PMC3734340.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    57. In vitro perfused human capillary networks. Tissue Eng Part C Methods. 2013 Sep; 19(9):730-7. Moya ML, Hsu YH, Lee AP, Hughes CC, George SC. PMID: 23320912; PMCID: PMC3719485.
      View in: PubMed   Mentions: 192     Fields:    Translation:Humans
    58. Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):513-22. Newman AC, Chou W, Welch-Reardon KM, Fong AH, Popson SA, Phan DT, Sandoval DR, Nguyen DP, Gershon PD, Hughes CC. PMID: 23288153; PMCID: PMC3638018.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    59. Full range physiological mass transport control in 3D tissue cultures. Lab Chip. 2013 Jan 07; 13(1):81-9. Hsu YH, Moya ML, Abiri P, Hughes CC, George SC, Lee AP. PMID: 23090158; PMCID: PMC3510322.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    60. Macrophages and angiogenesis: a role for Wnt signaling. Vasc Cell. 2012 Aug 31; 4(1):13. Newman AC, Hughes CC. PMID: 22938389; PMCID: PMC3479425.
      View in: PubMed   Mentions: 35  
    61. BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis. 2012 Sep; 15(3):497-509. Kim JH, Peacock MR, George SC, Hughes CC. PMID: 22622516; PMCID: PMC3423339.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    62. Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues. Tissue Eng Part C Methods. 2012 Sep; 18(9):697-709. White SM, Hingorani R, Arora RP, Hughes CC, George SC, Choi B. PMID: 22435776; PMCID: PMC3427639.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    63. Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. Nat Commun. 2012 Jan 10; 3:616. Benzinou M, Clermont FF, Letteboer TG, Kim JH, Espejel S, Harradine KA, Arbelaez J, Luu MT, Roy R, Quigley D, Higgins MN, Zaid M, Aouizerat BE, van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Plauchu H, Hughes CC, Westermann CJ, Akhurst RJ. PMID: 22233626; PMCID: PMC3509798.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    64. The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Mol Biol Cell. 2011 Oct; 22(20):3791-800. Newman AC, Nakatsu MN, Chou W, Gershon PD, Hughes CC. PMID: 21865599; PMCID: PMC3192859.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansCells
    65. Estradiol stimulates capillary formation by human endothelial progenitor cells: role of estrogen receptor-{alpha}/{beta}, heme oxygenase 1, and tyrosine kinase. Hypertension. 2010 Sep; 56(3):397-404. Baruscotti I, Barchiesi F, Jackson EK, Imthurn B, Stiller R, Kim JH, Schaufelberger S, Rosselli M, Hughes CC, Dubey RK. PMID: 20644008; PMCID: PMC2936691.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    66. Rapid anastomosis of endothelial progenitor cell-derived vessels with host vasculature is promoted by a high density of cotransplanted fibroblasts. Tissue Eng Part A. 2010 Feb; 16(2):585-94. Chen X, Aledia AS, Popson SA, Him L, Hughes CC, George SC. PMID: 19737050; PMCID: PMC2813071.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    67. Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS One. 2009 Nov 16; 4(11):e7841. Crampton SP, Wu B, Park EJ, Kim JH, Solomon C, Waterman ML, Hughes CC. PMID: 19924227; PMCID: PMC2773007.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    68. Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Eng Part A. 2009 Jun; 15(6):1363-71. Chen X, Aledia AS, Ghajar CM, Griffith CK, Putnam AJ, Hughes CC, George SC. PMID: 18976155; PMCID: PMC2792096.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    69. TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene. 2009 Apr 15; 435(1-2):36-44. Johnston DA, Dong B, Hughes CC. PMID: 19393188; PMCID: PMC2674625.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    70. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar; 77(2):78-86. Lu L, Payvandi F, Wu L, Zhang LH, Hariri RJ, Man HW, Chen RS, Muller GW, Hughes CC, Stirling DI, Schafer PH, Bartlett JB. PMID: 18805433.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansAnimalsCells
    71. Endothelial-stromal interactions in angiogenesis. Curr Opin Hematol. 2008 May; 15(3):204-9. Hughes CC. PMID: 18391786; PMCID: PMC6606556.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansCells
    72. Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circ Res. 2008 Mar 28; 102(6):637-52. Holderfield MT, Hughes CC. PMID: 18369162.
      View in: PubMed   Mentions: 147     Fields:    Translation:HumansAnimalsCells
    73. TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood. 2008 May 15; 111(10):4997-5007. Sainson RC, Johnston DA, Chu HC, Holderfield MT, Nakatsu MN, Crampton SP, Davis J, Conn E, Hughes CC. PMID: 18337563; PMCID: PMC2384130.
      View in: PubMed   Mentions: 157     Fields:    Translation:HumansCells
    74. An optimized three-dimensional in vitro model for the analysis of angiogenesis. Methods Enzymol. 2008; 443:65-82. Nakatsu MN, Hughes CC. PMID: 18772011.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansCells
    75. The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophys J. 2008 Mar 01; 94(5):1930-41. Ghajar CM, Chen X, Harris JW, Suresh V, Hughes CC, Jeon NL, Putnam AJ, George SC. PMID: 17993494; PMCID: PMC2242748.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    76. A conserved mechanism for steroid receptor translocation to the plasma membrane. J Biol Chem. 2007 Aug 03; 282(31):22278-88. Pedram A, Razandi M, Sainson RC, Kim JK, Hughes CC, Levin ER. PMID: 17535799.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansAnimalsCells
    77. Optimized fibrin gel bead assay for the study of angiogenesis. J Vis Exp. 2007; (3):186. Nakatsu MN, Davis J, Hughes CC. PMID: 18978935; PMCID: PMC2570172.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    78. Isolation of human umbilical vein endothelial cells (HUVEC). J Vis Exp. 2007; (3):183. Crampton SP, Davis J, Hughes CC. PMID: 18978951; PMCID: PMC2576276.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    79. Christopher Hughes: an in vitro model for the study of angiogenesis (interview). J Vis Exp. 2007; (3):175. Hughes CC. PMID: 18978990; PMCID: PMC2535841.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    80. Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity. 2007 Feb; 26(2):227-39. Wu B, Crampton SP, Hughes CC. PMID: 17306568; PMCID: PMC1855210.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    81. Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue Eng. 2006 Oct; 12(10):2875-88. Ghajar CM, Blevins KS, Hughes CC, George SC, Putnam AJ. PMID: 17518656.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansCells
    82. HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. Biochem Biophys Res Commun. 2006 Aug 04; 346(3):637-48. Holderfield MT, Henderson Anderson AM, Kokubo H, Chin MT, Johnson RL, Hughes CC. PMID: 16782059.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    83. Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT. J Interferon Cytokine Res. 2005 Oct; 25(10):604-16. Payvandi F, Wu L, Naziruddin SD, Haley M, Parton A, Schafer PH, Chen RS, Muller GW, Hughes CC, Stirling DI. PMID: 16241859.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    84. Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. Int Immunol. 2005 Jun; 17(6):737-47. Mestas J, Crampton SP, Hori T, Hughes CC. PMID: 15908450.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    85. Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB J. 2005 Jun; 19(8):1027-9. Sainson RC, Aoto J, Nakatsu MN, Holderfield M, Conn E, Koller E, Hughes CC. PMID: 15774577.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    86. Diffusion limits of an in vitro thick prevascularized tissue. Tissue Eng. 2005 Jan-Feb; 11(1-2):257-66. Griffith CK, Miller C, Sainson RC, Calvert JW, Jeon NL, Hughes CC, George SC. PMID: 15738680.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansCells
    87. Of mice and not men: differences between mouse and human immunology. J Immunol. 2004 Mar 01; 172(5):2731-8. Mestas J, Hughes CC. PMID: 14978070.
      View in: PubMed   Mentions: 1578     Fields:    Translation:HumansAnimals
    88. VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model. Lab Invest. 2003 Dec; 83(12):1873-85. Nakatsu MN, Sainson RC, Pérez-del-Pulgar S, Aoto JN, Aitkenhead M, Taylor KL, Carpenter PM, Hughes CC. PMID: 14691306.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    89. Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res. 2003 Sep; 66(2):102-12. Nakatsu MN, Sainson RC, Aoto JN, Taylor KL, Aitkenhead M, Pérez-del-Pulgar S, Carpenter PM, Hughes CC. PMID: 12935768.
      View in: PubMed   Mentions: 187     Fields:    Translation:HumansCells
    90. Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvasc Res. 2002 Nov; 64(3):372-83. Taylor KL, Henderson AM, Hughes CC. PMID: 12453432.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansCells
    91. Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. J Biol Chem. 2002 Dec 27; 277(52):50768-75. Pedram A, Razandi M, Aitkenhead M, Hughes CC, Levin ER. PMID: 12372818.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansCells
    92. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J Immunol. 2002 Oct 01; 169(7):3581-8. Mazanet MM, Hughes CC. PMID: 12244148.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    93. Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. J Immunol. 2002 Oct 01; 169(7):3717-25. Murphy LL, Hughes CC. PMID: 12244165.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    94. Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvasc Res. 2002 Mar; 63(2):159-71. Aitkenhead M, Wang SJ, Nakatsu MN, Mestas J, Heard C, Hughes CC. PMID: 11866539.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
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