Christopher C. Hughes

Title(s)Professor and Associate Dean for Research and Innovation, Molecular Biology & Biochemistry
SchoolSchool of Biological Sciences
Address2400 Biological Sciences III
Zot 3900
Irvine CA 92697
Phone(949) 824-8771, 8143, 3379
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    Collapse Research 
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    A Vascularized Micro-Organ platform for the study of Brain-BBB-Blood interaction
    NIH R61HL154307Sep 3, 2020 - Aug 31, 2022
    Role: Principal Investigator
    A 3D vascularized islet biomimetic to model type 1 diabetes
    NIH UG3DK122639Aug 1, 2019 - Jul 31, 2024
    Role: Co-Principal Investigator
    A 3D vascularized islet biomimetic to model type 1 diabetes
    NIH UH3DK122639Aug 1, 2019 - Jul 31, 2024
    Role: Co-Principal Investigator
    Modular monitoring of hormone release from human islets
    NIH UC4DK116283Sep 15, 2017 - Aug 31, 2021
    Role: Co-Principal Investigator
    Microphysiological systems to model vascular malformations
    NIH UH3HL141799Sep 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Microphysiological systems to model vascular malformations
    NIH UG3HL141799Sep 1, 2017 - Jul 31, 2019
    Role: Principal Investigator
    Real-time bioluminescent detection of circulating biomarkers
    NIH R21EB022704Aug 15, 2016 - May 31, 2019
    Role: Principal Investigator
    A 3-D biomimetic human islet to model beta cell function in health and disease
    NIH UC4DK104202Sep 20, 2014 - Jun 30, 2019
    Role: Co-Principal Investigator
    (PQD5) Development of in Vitro Vascularized Microtumors for Drug Screening
    NIH R01CA180122Aug 1, 2013 - Jun 30, 2018
    Role: Principal Investigator
    Training Program in Cardiovascular Applied Research and Entrepreneurship
    NIH T32HL116270Jun 1, 2013 - May 31, 2023
    Role: Principal Investigator
    A 3-D In Vitro Platform of Tumor Metastasis (PQ24)
    NIH R01CA170879Aug 20, 2012 - Jun 30, 2017
    Role: Co-Principal Investigator
    Encapsulated engineered microtumors: A platform for high throughput drug screenin
    NIH R21CA154187Jan 1, 2011 - Dec 31, 2013
    Role: Principal Investigator
    Creating a prevascularized thick implantable human tissue
    NIH R21HL104203Jun 1, 2010 - Apr 30, 2013
    Role: Co-Principal Investigator
    Bidirectional Notch Signaling and Angiogenesis
    NIH R01HL086959Jan 19, 2007 - Dec 31, 2010
    Role: Principal Investigator
    Molecular Approaches targeted on blocking angiogenesis
    NIH R01HL060067Apr 1, 1999 - Feb 28, 2015
    Role: Principal Investigator
    Endothelial Cell Regulation of T Cell Activation
    NIH R01AI040710Jun 1, 1996 - Apr 30, 2007
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system. Front Cardiovasc Med. 2024; 11:1360364. Hatch CJ, Piombo SD, Fang JS, Gach JS, Ewald ML, Van Trigt WK, Coon BG, Tong JM, Forthal DN, Hughes CCW. PMID: 38576426; PMCID: PMC10991679.
      View in: PubMed   Mentions:
    2. A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions. bioRxiv. 2024 Mar 12. Fang JS, Hatch CJ, Andrejecsk J, Trigt WV, Juat DJ, Chen YH, Matsumoto S, Lee AP, Hughes CCW. PMID: 38559155; PMCID: PMC10979959.
      View in: PubMed   Mentions:
    3. A vascularized 3D model of the human pancreatic islet forex vivostudy of immune cell-islet interaction. Biofabrication. 2024 01 11; 16(2). Bender RHF, O'Donnell BT, Shergill B, Pham BQ, Tahmouresie S, Sanchez CN, Juat DJ, Hatch MMS, Shirure VS, Wortham M, Nguyen-Ngoc KV, Jun Y, Gaetani R, Christman KL, Teyton L, George SC, Sander M, Hughes CCW. PMID: 38128127; PMCID: PMC10782895.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Targeting tumor-stromal interactions in triple-negative breast cancer using a human vascularized micro-tumor model. Breast Cancer Res. 2024 01 05; 26(1):5. Hachey SJ, Hatch CJ, Gaebler D, Mocherla A, Nee K, Kessenbrock K, Hughes CCW. PMID: 38183074; PMCID: PMC10768273.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Establishing a Physiologic Human Vascularized Micro-Tumor Model for Cancer Research. J Vis Exp. 2023 09 15; (199). Hachey SJ, Gaebler D, Hughes CCW. PMID: 37782104.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls. Ann Surg Oncol. 2023 Jun; 30(6):3833-3844. Vallejos PA, Gonda A, Yu J, Sullivan BG, Ostowari A, Kwong ML, Choi A, Selleck MJ, Kabagwira J, Fuller RN, Gironda DJ, Levine EA, Hughes CCW, Wall NR, Miller LD, Senthil M. PMID: 36864326; PMCID: PMC10175396.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Exosomes as a Source of Biomarkers for Gastrointestinal Cancers. Cancers (Basel). 2023 Feb 16; 15(4). Yu J, Ostowari A, Gonda A, Mashayekhi K, Dayyani F, Hughes CCW, Senthil M. PMID: 36831603; PMCID: PMC9954462.
      View in: PubMed   Mentions: 3  
    8. A human vascularized microtumor model of patient-derived colorectal cancer recapitulates clinical disease. Transl Res. 2023 05; 255:97-108. Hachey SJ, Sobrino A, Lee JG, Jafari MD, Klempner SJ, Puttock EJ, Edwards RA, Lowengrub JS, Waterman ML, Zell JA, Hughes CCW. PMID: 36481562; PMCID: PMC10593408.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Organotypic stromal cells impact endothelial cell transcriptome in 3D microvessel networks. Sci Rep. 2022 Nov 28; 12(1):20434. Curtis MB, Kelly N, Hughes CCW, George SC. PMID: 36443378; PMCID: PMC9705391.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. GNAQ mutations drive port wine birthmark-associated Sturge-Weber syndrome: A review of pathobiology, therapies, and current models. Front Hum Neurosci. 2022; 16:1006027. Van Trigt WK, Kelly KM, Hughes CCW. PMID: 36405075; PMCID: PMC9670321.
      View in: PubMed   Mentions: 3  
    11. Deconstructing Allograft Adipose and Fascia Matrix: Fascia Matrix Improves Angiogenesis, Volume Retention, and Adipogenesis in a Rodent Model. Plast Reconstr Surg. 2023 01 01; 151(1):108-117. Ziegler ME, Sorensen AM, Banyard DA, Sayadi LR, Chnari E, Hatch MM, Tassey J, Mirzakhanyan Y, Gershon PD, Hughes CCW, Evans GRD, Widgerow AD. PMID: 36219861; PMCID: PMC10081826.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    12. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022 Apr 26; 39(4):110760. Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. PMID: 35476990; PMCID: PMC9128537.
      View in: PubMed   Mentions:    Fields:    
    13. Structure-based design of CDC42 effector interaction inhibitors for the treatment of cancer. Cell Rep. 2022 04 05; 39(1):110641. Jahid S, Ortega JA, Vuong LM, Acquistapace IM, Hachey SJ, Flesher JL, La Serra MA, Brindani N, La Sala G, Manigrasso J, Arencibia JM, Bertozzi SM, Summa M, Bertorelli R, Armirotti A, Jin R, Liu Z, Chen CF, Edwards R, Hughes CCW, De Vivo M, Ganesan AK. PMID: 35385746; PMCID: PMC9127750.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review. Oncologist. 2022 03 11; 27(3):210-219. Juat DJ, Hachey SJ, Billimek J, Del Rosario MP, Nelson EL, Hughes CCW, Zell JA. PMID: 35274719; PMCID: PMC8914488.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Regulation of Partial and Reversible Endothelial-to-Mesenchymal Transition in Angiogenesis. Front Cell Dev Biol. 2021; 9:702021. Fang JS, Hultgren NW, Hughes CCW. PMID: 34692672; PMCID: PMC8529039.
      View in: PubMed   Mentions: 8  
    16. Correction: The vascular niche in next generation microphysiological systems. Lab Chip. 2021 Sep 14; 21(18):3615-3616. Ewald ML, Chen YH, Lee AP, Hughes CCW. PMID: 34472547.
      View in: PubMed   Mentions: 2     Fields:    
    17. The vascular niche in next generation microphysiological systems. Lab Chip. 2021 09 07; 21(17):3244-3262. Ewald ML, Chen YH, Lee AP, Hughes CCW. PMID: 34396383; PMCID: PMC8635227.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    18. Tumor-on-chip modeling of organ-specific cancer and metastasis. Adv Drug Deliv Rev. 2021 08; 175:113798. Del Piccolo N, Shirure VS, Bi Y, Goedegebuure SP, Gholami S, Hughes CCW, Fields RC, George SC. PMID: 34015419.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    19. Engineering Vascularized Organoid-on-a-Chip Models. Annu Rev Biomed Eng. 2021 07 13; 23:141-167. Shirure VS, Hughes CCW, George SC. PMID: 33756087.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    20. An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy. Lab Chip. 2021 04 07; 21(7):1333-1351. Hachey SJ, Movsesyan S, Nguyen QH, Burton-Sojo G, Tankazyan A, Wu J, Hoang T, Zhao D, Wang S, Hatch MM, Celaya E, Gomez S, Chen GT, Davis RT, Nee K, Pervolarakis N, Lawson DA, Kessenbrock K, Lee AP, Lowengrub J, Waterman ML, Hughes CCW. PMID: 33605955; PMCID: PMC8525497.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    21. A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks. Microsyst Nanoeng. 2021; 7:4. Yue T, Zhao D, Phan DTT, Wang X, Park JJ, Biviji Z, Hughes CCW, Lee AP. PMID: 33456784; PMCID: PMC7787972.
      View in: PubMed   Mentions: 12  
    22. Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis. Nat Commun. 2020 10 26; 11(1):5400. Hultgren NW, Fang JS, Ziegler ME, Ramirez RN, Phan DTT, Hatch MMS, Welch-Reardon KM, Paniagua AE, Kim LS, Shon NN, Williams DS, Mortazavi A, Hughes CCW. PMID: 33106502; PMCID: PMC7588439.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    23. Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs. Toxicology. 2020 12 01; 445:152601. Liu Y, Sakolish C, Chen Z, Phan DTT, Bender RHF, Hughes CCW, Rusyn I. PMID: 32980478; PMCID: PMC7606810.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    24. Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions. Stem Cell Reports. 2019 03 05; 12(3):451-460. Faal T, Phan DTT, Davtyan H, Scarfone VM, Varady E, Blurton-Jones M, Hughes CCW, Inlay MA. PMID: 30745035; PMCID: PMC6409424.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    25. Evaluation of Different Decellularization Protocols on the Generation of Pancreas-Derived Hydrogels. Tissue Eng Part C Methods. 2018 12; 24(12):697-708. Gaetani R, Aude S, DeMaddalena LL, Strassle H, Dzieciatkowska M, Wortham M, Bender RHF, Nguyen-Ngoc KV, Schmid-Schöenbein GW, George SC, Hughes CCW, Sander M, Hansen KC, Christman KL. PMID: 30398401; PMCID: PMC6306687.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    26. Applications of tumor chip technology. Lab Chip. 2018 09 26; 18(19):2893-2912. Hachey SJ, Hughes CCW. PMID: 30156248; PMCID: PMC6207449.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimals
    27. Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia. Angiogenesis. 2019 02; 22(1):145-155. Faughnan ME, Gossage JR, Chakinala MM, Oh SP, Kasthuri R, Hughes CCW, McWilliams JP, Parambil JG, Vozoris N, Donaldson J, Paul G, Berry P, Sprecher DL. PMID: 30191360; PMCID: PMC6510884.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    28. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. PMID: 29766399; PMCID: PMC6237663.
      View in: PubMed   Mentions: 257     Fields:    Translation:HumansAnimals
    29. A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function. Lab Chip. 2018 07 24; 18(15):2167-2177. Wang X, Zhao D, Phan DTT, Liu J, Chen X, Yang B, Hughes CCW, Zhang W, Lee AP. PMID: 29931005; PMCID: PMC6057814.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    30. Multiscale modeling of glioblastoma. Transl Cancer Res. 2018 Feb; 7(Suppl 1):S96-S98. Yan H, Romero-López M, Benitez LI, Di K, Frieboes HB, Hughes CCW, Bota DA, Lowengrub JS. PMID: 30211018; PMCID: PMC6130886.
      View in: PubMed   Mentions:
    31. Executive summary of the 12th HHT international scientific conference. Angiogenesis. 2018 02; 21(1):169-181. Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ. PMID: 29147802.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    32. 3D Mathematical Modeling of Glioblastoma Suggests That Transdifferentiated Vascular Endothelial Cells Mediate Resistance to Current Standard-of-Care Therapy. Cancer Res. 2017 08 01; 77(15):4171-4184. Yan H, Romero-López M, Benitez LI, Di K, Frieboes HB, Hughes CCW, Bota DA, Lowengrub JS. PMID: 28536277; PMCID: PMC5540807.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    33. Blood-brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood-central nervous system interface. Exp Biol Med (Maywood). 2017 11; 242(17):1669-1678. Phan DT, Bender RHF, Andrejecsk JW, Sobrino A, Hachey SJ, George SC, Hughes CC. PMID: 28195514; PMCID: PMC5786363.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    34. A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications. Lab Chip. 2017 01 31; 17(3):511-520. Phan DTT, Wang X, Craver BM, Sobrino A, Zhao D, Chen JC, Lee LYN, George SC, Lee AP, Hughes CCW. PMID: 28092382; PMCID: PMC6995340.
      View in: PubMed   Mentions: 115     Fields:    Translation:Humans
    35. 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels. Methods Mol Biol. 2017; 1612:325-344. Wang X, Phan DTT, George SC, Hughes CCW, Lee AP. PMID: 28634954; PMCID: PMC7838062.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    36. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 2017 02; 116:118-129. Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. PMID: 27914984; PMCID: PMC5226635.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    37. Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng. 2017 03; 64(3):538-548. Yan H, Romero-Lopez M, Frieboes HB, Hughes CC, Lowengrub JS. PMID: 27723576; PMCID: PMC5501302.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. 3D microtumors in vitro supported by perfused vascular networks. Sci Rep. 2016 08 23; 6:31589. Sobrino A, Phan DT, Datta R, Wang X, Hachey SJ, Romero-López M, Gratton E, Lee AP, George SC, Hughes CC. PMID: 27549930; PMCID: PMC4994029.
      View in: PubMed   Mentions: 153     Fields:    Translation:HumansCells
    39. Three-Dimensional Adult Cardiac Extracellular Matrix Promotes Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Tissue Eng Part A. 2016 08; 22(15-16):1016-25. Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC. PMID: 27392582; PMCID: PMC4991595.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    40. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomater. 2016 10 01; 43:122-138. Arulmoli J, Wright HJ, Phan DTT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CCW, Flanagan LA. PMID: 27475528; PMCID: PMC5386322.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    41. Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cancers. Breast Cancer Res. 2016 05 11; 18(1):50. Gray MJ, Gong J, Hatch MM, Nguyen V, Hughes CC, Hutchins JT, Freimark BD. PMID: 27169467; PMCID: PMC4864933.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    42. mTORC2 mediates CXCL12-induced angiogenesis. Angiogenesis. 2016 07; 19(3):359-71. Ziegler ME, Hatch MM, Wu N, Muawad SA, Hughes CC. PMID: 27106789; PMCID: PMC4959910.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    43. Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma. Cancer Immunol Res. 2016 06; 4(6):531-40. Freimark BD, Gong J, Ye D, Gray MJ, Nguyen V, Yin S, Hatch MM, Hughes CC, Schroit AJ, Hutchins JT, Brekken RA, Huang X. PMID: 27045021; PMCID: PMC7821912.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    44. An on-chip microfluidic pressure regulator that facilitates reproducible loading of cells and hydrogels into microphysiological system platforms. Lab Chip. 2016 Mar 07; 16(5):868-876. Wang X, Phan DTT, Zhao D, George SC, Hughes CCW, Lee AP. PMID: 26879519; PMCID: PMC4911208.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    45. Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels. Lab Chip. 2016 Jan 21; 16(2):282-90. Wang X, Phan DT, Sobrino A, George SC, Hughes CC, Lee AP. PMID: 26616908; PMCID: PMC4869859.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    46. Executive summary of the 11th HHT international scientific conference. Angiogenesis. 2015 Oct; 18(4):511-24. Arthur H, Geisthoff U, Gossage JR, Hughes CC, Lacombe P, Meek ME, Oh P, Roman BL, Trerotola SO, Velthuis S, Wooderchak-Donahue W. PMID: 26391603.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    47. A role for partial endothelial-mesenchymal transitions in angiogenesis? Arterioscler Thromb Vasc Biol. 2015 Feb; 35(2):303-8. Welch-Reardon KM, Wu N, Hughes CC. PMID: 25425619; PMCID: PMC4911209.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    48. Implanted cell-dense prevascularized tissues develop functional vasculature that supports reoxygenation after thrombosis. Tissue Eng Part A. 2014 Sep; 20(17-18):2316-28. White SM, Pittman CR, Hingorani R, Arora R, Esipova TV, Vinogradov SA, Hughes CC, Choi B, George SC. PMID: 24593148; PMCID: PMC4161156.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    49. A three-dimensional in vitro model of tumor cell intravasation. Integr Biol (Camb). 2014 Jun; 6(6):603-10. Ehsan SM, Welch-Reardon KM, Waterman ML, Hughes CC, George SC. PMID: 24763498; PMCID: PMC4046910.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    50. A strategy for integrating essential three-dimensional microphysiological systems of human organs for realistic anticancer drug screening. Exp Biol Med (Maywood). 2014 Sep; 239(9):1240-54. Heylman C, Sobrino A, Shirure VS, Hughes CC, George SC. PMID: 24740872; PMCID: PMC4156538.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    51. Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1011-9. Popson SA, Ziegler ME, Chen X, Holderfield MT, Shaaban CI, Fong AH, Welch-Reardon KM, Papkoff J, Hughes CC. PMID: 24603679; PMCID: PMC3993998.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    52. Angiogenic sprouting is regulated by endothelial cell expression of Slug. J Cell Sci. 2014 May 01; 127(Pt 9):2017-28. Welch-Reardon KM, Ehsan SM, Wang K, Wu N, Newman AC, Romero-Lopez M, Fong AH, George SC, Edwards RA, Hughes CC. PMID: 24554431; PMCID: PMC4004976.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    53. A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. Lab Chip. 2013 Aug 07; 13(15):2990-8. Hsu YH, Moya ML, Hughes CC, George SC, Lee AP. PMID: 23723013; PMCID: PMC3734340.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    54. In vitro perfused human capillary networks. Tissue Eng Part C Methods. 2013 Sep; 19(9):730-7. Moya ML, Hsu YH, Lee AP, Hughes CC, George SC. PMID: 23320912; PMCID: PMC3719485.
      View in: PubMed   Mentions: 191     Fields:    Translation:Humans
    55. Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):513-22. Newman AC, Chou W, Welch-Reardon KM, Fong AH, Popson SA, Phan DT, Sandoval DR, Nguyen DP, Gershon PD, Hughes CC. PMID: 23288153; PMCID: PMC3638018.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
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