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Timothy L. Downing

Title(s)Assistant Professor, Biomedical Engineering
Phone(949) 824-8744
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    Collapse Research 
    Collapse Research Activities and Funding
    Spatial epigenomics: A new framework for overcoming mechanical heterogeneity in solid tumors
    NIH/NCI DP2CA250382Sep 19, 2019 - Jun 30, 2024
    Role: Principal Investigator
    Epigenetic regulation of macrophage response to biomaterial implants
    NIH/NIBIB R21EB027840Apr 18, 2019 - Jan 31, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Meli VS, Veerasubramanian PK, Atcha H, Reitz Z, Downing TL, Liu WF. Biophysical regulation of macrophages in health and disease. J Leukoc Biol. 2019 Aug; 106(2):283-299. PMID: 30861205.
      View in: PubMed
    2. Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A. Author Correction: Global delay in nascent strand DNA methylation. Nat Struct Mol Biol. 2018 04; 25(4):355. PMID: 29581568.
      View in: PubMed
    3. Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A. Global delay in nascent strand DNA methylation. Nat Struct Mol Biol. 2018 04; 25(4):327-332. PMID: 29531288.
      View in: PubMed
    4. Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, S├ęgaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W. Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 07 26; 9(400). PMID: 28747514.
      View in: PubMed
    5. Downing TL, Soto J, Morez C, Houssin T, Fritz A, Yuan F, Chu J, Patel S, Schaffer DV, Li S. Biophysical regulation of epigenetic state and cell reprogramming. Nat Mater. 2013 Dec; 12(12):1154-62. PMID: 24141451.
      View in: PubMed
    6. Saadai P, Wang A, Nout YS, Downing TL, Lofberg K, Beattie MS, Bresnahan JC, Li S, Farmer DL. Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele. J Pediatr Surg. 2013 Jan; 48(1):158-63. PMID: 23331809.
      View in: PubMed
    7. Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. J Control Release. 2012 Aug 10; 161(3):910-7. PMID: 22634093.
      View in: PubMed
    8. Saadai P, Nout YS, Encinas J, Wang A, Downing TL, Beattie MS, Bresnahan JC, Li S, Farmer DL. Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep. J Pediatr Surg. 2011 Dec; 46(12):2279-83. PMID: 22152865.
      View in: PubMed