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Timothy L. Downing

Title(s)Assistant Professor, Biomedical Engineering
Address2408 Engineering III
Zot 2730
Irvine CA 92697
Phone(949) 824-8744
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    Collapse Research 
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    Spatial epigenomics: A new framework for overcoming mechanical heterogeneity in solid tumors
    NIH DP2CA250382Sep 19, 2019 - May 31, 2024
    Role: Principal Investigator
    Epigenetic regulation of macrophage response to biomaterial implants
    NIH R21EB027840Apr 18, 2019 - Jan 31, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Sci Adv. 2020 Dec; 6(49). Meli VS, Atcha H, Veerasubramanian PK, Nagalla RR, Luu TU, Chen EY, Guerrero-Juarez CF, Yamaga K, Pandori W, Hsieh JY, Downing TL, Fruman DA, Lodoen MB, Plikus MV, Wang W, Liu WF. PMID: 33277245.
      View in: PubMed   Mentions:    Fields:    
    2. Stochastic modeling reveals kinetic heterogeneity in post-replication DNA methylation. PLoS Comput Biol. 2020 04; 16(4):e1007195. Busto-Moner L, Morival J, Ren H, Fahim A, Reitz Z, Downing TL, Read EL. PMID: 32275652.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Biophysical regulation of macrophages in health and disease. J Leukoc Biol. 2019 08; 106(2):283-299. Meli VS, Veerasubramanian PK, Atcha H, Reitz Z, Downing TL, Liu WF. PMID: 30861205.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Author Correction: Global delay in nascent strand DNA methylation. Nat Struct Mol Biol. 2018 04; 25(4):355. Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A. PMID: 29581568.
      View in: PubMed   Mentions:    Fields:    
    5. Global delay in nascent strand DNA methylation. Nat Struct Mol Biol. 2018 04; 25(4):327-332. Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A. PMID: 29531288.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    6. Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 07 26; 9(400). Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W. PMID: 28747514.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    7. Biophysical regulation of epigenetic state and cell reprogramming. Nat Mater. 2013 Dec; 12(12):1154-62. Downing TL, Soto J, Morez C, Houssin T, Fritz A, Yuan F, Chu J, Patel S, Schaffer DV, Li S. PMID: 24141451.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    8. Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele. J Pediatr Surg. 2013 Jan; 48(1):158-63. Saadai P, Wang A, Nout YS, Downing TL, Lofberg K, Beattie MS, Bresnahan JC, Li S, Farmer DL. PMID: 23331809.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    9. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. J Control Release. 2012 Aug 10; 161(3):910-7. Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S. PMID: 22634093.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    10. Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep. J Pediatr Surg. 2011 Dec; 46(12):2279-83. Saadai P, Nout YS, Encinas J, Wang A, Downing TL, Beattie MS, Bresnahan JC, Li S, Farmer DL. PMID: 22152865.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
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