Timothy Downing • UCI Profiles

Timothy L. Downing

Title(s)	Assistant Professor, Biomedical Engineering
Address	2408 Engineering III Zot 2730 Irvine CA 92697
Phone	(949) 824-8744
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Research

Research Activities and Funding

Spatial epigenomics: A new framework for overcoming mechanical heterogeneity in solid tumors
NIH DP2CA250382Sep 19, 2019 - May 31, 2024
Role: Principal Investigator

Epigenetic regulation of macrophage response to biomaterial implants
NIH R21EB027840Apr 18, 2019 - Jan 31, 2021
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

DNA methylation analysis reveals epimutation hotspots in patients with dilated cardiomyopathy-associated laminopathies. Clin Epigenetics. 2021 Jul 10; 13(1):139. Morival JLP, Widyastuti HP, Nguyen CHH, Zaragoza MV, Downing TL. PMID: 34246298.

View in: PubMed Mentions: Fields:
Gen Genetics
The impact of age-related hypomethylated DNA on immune signaling upon cellular demise. Trends Immunol. 2021 06; 42(6):464-468. Urban LA, Trinh A, Pearlman E, Siryaporn A, Downing TL. PMID: 33994111.

View in: PubMed Mentions: Fields:
All Allergy and Immunology
Translation:Humans Cells
YAP-mediated mechanotransduction tunes the macrophage inflammatory response. Sci Adv. 2020 Dec; 6(49). Meli VS, Atcha H, Veerasubramanian PK, Nagalla RR, Luu TU, Chen EY, Guerrero-Juarez CF, Yamaga K, Pandori W, Hsieh JY, Downing TL, Fruman DA, Lodoen MB, Plikus MV, Wang W, Liu WF. PMID: 33277245.

View in: PubMed Mentions: 2 Fields:
Sci Science
Biophysical and epigenetic regulation of cancer stemness, invasiveness and immune action. Curr Tissue Microenviron Rep. 2020 Dec; 1(4):277-300. Veerasubramanian PK, Trinh A, Akhtar N, Liu WF, Downing TL. PMID: 33817661.

View in: PubMed Mentions:
Stochastic modeling reveals kinetic heterogeneity in post-replication DNA methylation. PLoS Comput Biol. 2020 04; 16(4):e1007195. Busto-Moner L, Morival J, Ren H, Fahim A, Reitz Z, Downing TL, Read EL. PMID: 32275652.

View in: PubMed Mentions: 3 Fields:
Com Computational Biology
Translation:Humans Animals Cells
Biophysical regulation of macrophages in health and disease. J Leukoc Biol. 2019 08; 106(2):283-299. Meli VS, Veerasubramanian PK, Atcha H, Reitz Z, Downing TL, Liu WF. PMID: 30861205.

View in: PubMed Mentions: 13 Fields:
All Allergy and Immunology
Translation:Humans Animals Cells
Author Correction: Global delay in nascent strand DNA methylation. Nat Struct Mol Biol. 2018 04; 25(4):355. Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A. PMID: 29581568.

View in: PubMed Mentions: Fields:
Mol Molecular Biology
Global delay in nascent strand DNA methylation. Nat Struct Mol Biol. 2018 04; 25(4):327-332. Charlton J, Downing TL, Smith ZD, Gu H, Clement K, Pop R, Akopian V, Klages S, Santos DP, Tsankov AM, Timmermann B, Ziller MJ, Kiskinis E, Gnirke A, Meissner A. PMID: 29531288.

View in: PubMed Mentions: 18 Fields:
Mol Molecular Biology
Translation:Humans Cells
Mechanoresponsive stem cells to target cancer metastases through biophysical cues. Sci Transl Med. 2017 07 26; 9(400). Liu L, Zhang SX, Liao W, Farhoodi HP, Wong CW, Chen CC, Ségaliny AI, Chacko JV, Nguyen LP, Lu M, Polovin G, Pone EJ, Downing TL, Lawson DA, Digman MA, Zhao W. PMID: 28747514.

View in: PubMed Mentions: 16 Fields:
Med Medicine (General)Sci Science
Translation:Humans Animals Cells
Biophysical regulation of epigenetic state and cell reprogramming. Nat Mater. 2013 Dec; 12(12):1154-62. Downing TL, Soto J, Morez C, Houssin T, Fritz A, Yuan F, Chu J, Patel S, Schaffer DV, Li S. PMID: 24141451.

View in: PubMed Mentions: 118 Fields:
Che Chemistry Sci Science
Translation:Humans Animals Cells
Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele. J Pediatr Surg. 2013 Jan; 48(1):158-63. Saadai P, Wang A, Nout YS, Downing TL, Lofberg K, Beattie MS, Bresnahan JC, Li S, Farmer DL. PMID: 23331809.

View in: PubMed Mentions: 24 Fields:
Gen General Surgery Ped Pediatrics
Translation:Humans Animals Cells
Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. J Control Release. 2012 Aug 10; 161(3):910-7. Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S. PMID: 22634093.

View in: PubMed Mentions: 19 Fields:
Pha Pharmacology
Translation:Animals
Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep. J Pediatr Surg. 2011 Dec; 46(12):2279-83. Saadai P, Nout YS, Encinas J, Wang A, Downing TL, Beattie MS, Bresnahan JC, Li S, Farmer DL. PMID: 22152865.

View in: PubMed Mentions: 15 Fields:
Gen General Surgery Ped Pediatrics
Translation:Animals