Xing Dai

Title(s)Professor, Biological Chemistry
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-3101
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    Collapse Research 
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    Multiscale Models of Wound Cell Plasticity for Regeneration
    NIH U01AR073159Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Mammary basal/stem cell plasticity and regulation
    NIH R01GM123731Sep 10, 2017 - May 31, 2021
    Role: Principal Investigator
    EMT regulators in Epidermal Morphogenesis
    NIH R56AR064532Sep 1, 2015 - Aug 31, 2017
    Role: Principal Investigator
    Control of epithelial plasticity and differentiation in hair follicle stem/progenitor cells
    NIH R01AR068074Jul 22, 2015 - Jun 30, 2021
    Role: Principal Investigator
    Chromatin Regulation of Epithelial Progenitor Cell Self-Renewal by Pygo2
    NIH R01GM083089Jul 17, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Movo in embryonic development and skin differentiation
    NIH K02AR051482Jul 12, 2004 - Apr 30, 2009
    Role: Principal Investigator
    Role of Ovol Genes in Epidermal Development
    NIH R01AR047320Dec 1, 2000 - Jul 31, 2012
    Role: Principal Investigator
    NIH F32AR008456Mar 24, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Epithelial-Mesenchymal Plasticity and Endothelial-Mesenchymal Transition in Cutaneous Wound Healing. Cold Spring Harb Perspect Biol. 2023 08 01; 15(8). Vu R, Dragan M, Sun P, Werner S, Dai X. PMID: 36617638; PMCID: PMC10411868.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    2. Ovol1/2 loss-induced epidermal defects elicit skin immune activation and alter global metabolism. EMBO Rep. 2023 Jul 05; 24(7):e56214. Dragan M, Chen Z, Li Y, Le J, Sun P, Haensel D, Sureshchandra S, Pham A, Lu E, Pham KT, Verlande A, Vu R, Gutierrez G, Li W, Jang C, Masri S, Dai X. PMID: 37249012; PMCID: PMC10328084.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    3. Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication. Cell Rep. 2022 08 02; 40(5):111155. Vu R, Jin S, Sun P, Haensel D, Nguyen QH, Dragan M, Kessenbrock K, Nie Q, Dai X. PMID: 35926463; PMCID: PMC9901190.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    4. Defining mammary basal cell transcriptional states using single-cell RNA-sequencing. Sci Rep. 2022 03 22; 12(1):4893. Gutierrez G, Sun P, Han Y, Dai X. PMID: 35318370; PMCID: PMC8940936.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    5. Coordinate control of basal epithelial cell fate and stem cell maintenance by core EMT transcription factor Zeb1. Cell Rep. 2022 01 11; 38(2):110240. Han Y, Villarreal-Ponce A, Gutierrez G, Nguyen Q, Sun P, Wu T, Sui B, Berx G, Brabletz T, Kessenbrock K, Zeng YA, Watanabe K, Dai X. PMID: 35021086; PMCID: PMC9894649.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    6. Altered Epithelial-mesenchymal Plasticity as a Result of Ovol2 Deletion Minimally Impacts the Self-renewal of Adult Mammary Basal Epithelial Cells. J Mammary Gland Biol Neoplasia. 2021 12; 26(4):377-386. Sun P, Han Y, Plikus M, Dai X. PMID: 34984648; PMCID: PMC8858298.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. Nfatc1's Role in Mammary Epithelial Morphogenesis and Basal Stem/progenitor Cell Self-renewal. J Mammary Gland Biol Neoplasia. 2021 12; 26(4):357-365. McNeil M, Han Y, Sun P, Watanabe K, Jiang J, Chen N, Yu Z, Zhou B, Dai X. PMID: 34932179; PMCID: PMC8858291.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    8. Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation. J Invest Dermatol. 2022 03; 142(3 Pt A):583-593.e5. Dragan M, Sun P, Chen Z, Ma X, Vu R, Shi Y, Villalta SA, Dai X. PMID: 34461129; PMCID: PMC9968377.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    9. OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia. J Invest Dermatol. 2021 06; 141(6):1542-1552. Sun P, Vu R, Dragan M, Haensel D, Gutierrez G, Nguyen Q, Greenberg E, Chen Z, Wu J, Atwood S, Pearlman E, Shi Y, Han W, Kessenbrock K, Dai X. PMID: 33333123; PMCID: PMC8532526.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    10. Integrated Single-Cell Transcriptomics and Chromatin Accessibility Analysis Reveals Regulators of Mammary Epithelial Cell Identity. Cell Rep. 2020 10 20; 33(3):108273. Pervolarakis N, Nguyen QH, Williams J, Gong Y, Gutierrez G, Sun P, Jhutty D, Zheng GXY, Nemec CM, Dai X, Watanabe K, Kessenbrock K. PMID: 33086071; PMCID: PMC7874899.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    11. Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics. Cell Rep. 2020 03 17; 30(11):3932-3947.e6. Haensel D, Jin S, Sun P, Cinco R, Dragan M, Nguyen Q, Cang Z, Gong Y, Vu R, MacLean AL, Kessenbrock K, Gratton E, Nie Q, Dai X. PMID: 32187560; PMCID: PMC7218802.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    12. Intermediate cell states in epithelial-to-mesenchymal transition. Phys Biol. 2019 01 18; 16(2):021001. Sha Y, Haensel D, Gutierrez G, Du H, Dai X, Nie Q. PMID: 30560804; PMCID: PMC6602058.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    13. Ex Vivo Imaging and Genetic Manipulation of Mouse Hair Follicle Bulge Stem Cells. Methods Mol Biol. 2019; 1879:15-29. Haensel D, McNeil MA, Dai X. PMID: 29478134.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    14. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO Rep. 2019 01; 20(1). Haensel D, Sun P, MacLean AL, Ma X, Zhou Y, Stemmler MP, Brabletz S, Berx G, Plikus MV, Nie Q, Brabletz T, Dai X. PMID: 30413481; PMCID: PMC6322385.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    15. Inflammation: Memory beyond immunity. Nature. 2017 10 26; 550(7677):460-461. Dai X, Medzhitov R. PMID: 29045392.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Epithelial-to-mesenchymal transition in cutaneous wound healing: Where we are and where we are heading. Dev Dyn. 2018 03; 247(3):473-480. Haensel D, Dai X. PMID: 28795450; PMCID: PMC5809211.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimals
    17. Overexpression of Transcription Factor Ovol2 in Epidermal Progenitor Cells Results in Skin Blistering. J Invest Dermatol. 2017 08; 137(8):1805-1808. Lee B, Watanabe K, Haensel D, Sui JY, Dai X. PMID: 28457910.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States. PLoS Comput Biol. 2015 Nov; 11(11):e1004569. Hong T, Watanabe K, Ta CH, Villarreal-Ponce A, Nie Q, Dai X. PMID: 26554584; PMCID: PMC4640575.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    19. Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation. J R Soc Interface. 2014 Oct 06; 11(99). Gord A, Holmes WR, Dai X, Nie Q. PMID: 25100322; PMCID: PMC4233746.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    20. The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis. PLoS Genet. 2014 Jul; 10(7):e1004520. Salmans ML, Yu Z, Watanabe K, Cam E, Sun P, Smyth P, Dai X, Andersen B. PMID: 25079073; PMCID: PMC4117441.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10215-20. Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X. PMID: 24982158; PMCID: PMC4104891.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    22. Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell. 2014 Apr 14; 29(1):47-58. Lee B, Villarreal-Ponce A, Fallahi M, Ovadia J, Sun P, Yu QC, Ito S, Sinha S, Nie Q, Dai X. PMID: 24735878; PMCID: PMC4153751.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    23. Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor. Dev Cell. 2014 Apr 14; 29(1):59-74. Watanabe K, Villarreal-Ponce A, Sun P, Salmans ML, Fallahi M, Andersen B, Dai X. PMID: 24735879; PMCID: PMC4062651.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimals
    24. Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer. PLoS One. 2014; 9(3):e92317. Watanabe K, Biesinger J, Salmans ML, Roberts BS, Arthur WT, Cleary M, Andersen B, Xie X, Dai X. PMID: 24651522; PMCID: PMC3961325.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    25. Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. Cell Stem Cell. 2013 Jul 03; 13(1):48-61. Gu B, Watanabe K, Sun P, Fallahi M, Dai X. PMID: 23684539; PMCID: PMC3703489.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    26. Analysis of gene expression in skin using laser capture microdissection. Methods Mol Biol. 2013; 989:109-17. Lee B, Geyfman M, Andersen B, Dai X. PMID: 23483391.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Transcriptional control of epidermal stem cells. Adv Exp Med Biol. 2013; 786:157-73. Lee B, Dai X. PMID: 23696356.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    28. Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Cell Cycle. 2012 Jan 01; 11(1):79-87. Gu B, Watanabe K, Dai X. PMID: 22186018; PMCID: PMC3272233.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. A WNTer revisit: new faces of β-catenin and TCFs in pluripotency. Sci Signal. 2011 Sep 27; 4(193):pe41. Watanabe K, Dai X. PMID: 21971038.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Winning WNT: race to Wnt signaling inhibitors. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):5929-30. Watanabe K, Dai X. PMID: 21451134; PMCID: PMC3076855.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    31. Epithelial stem cells: an epigenetic and Wnt-centric perspective. J Cell Biochem. 2010 Aug 15; 110(6):1279-87. Gu B, Watanabe K, Dai X. PMID: 20564229; PMCID: PMC2923477.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms. BMC Syst Biol. 2010 Aug 09; 4:107. Christley S, Lee B, Dai X, Nie Q. PMID: 20696053; PMCID: PMC2936904.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    33. Using siRNA knockdown in HaCaT cells to study transcriptional control of epidermal proliferation potential. Methods Mol Biol. 2010; 585:107-25. Wells J, Dai X. PMID: 19908000.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    34. Cytokeratin expression during mouse embryonic and early postnatal mammary gland development. Histochem Cell Biol. 2010 Feb; 133(2):213-21. Sun P, Yuan Y, Li A, Li B, Dai X. PMID: 19937336; PMCID: PMC2807942.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    35. Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1. J Biol Chem. 2009 Oct 16; 284(42):29125-35. Wells J, Lee B, Cai AQ, Karapetyan A, Lee WJ, Rugg E, Sinha S, Nie Q, Dai X. PMID: 19700410; PMCID: PMC2781457.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    36. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009 Jun 01; 185(5):811-26. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, Li B, Dai X. PMID: 19487454; PMCID: PMC2711593.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    37. Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Dev Biol. 2008 Aug 15; 320(2):446-55. Nair M, Nagamori I, Sun P, Mishra DP, Rhéaume C, Li B, Sassone-Corsi P, Dai X. PMID: 18614164; PMCID: PMC2553271.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    38. Pygopus and the Wnt signaling pathway: a diverse set of connections. Bioessays. 2008 May; 30(5):448-56. Jessen S, Gu B, Dai X. PMID: 18404694.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    39. Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15; 318(2):224-35. Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M. PMID: 18452912; PMCID: PMC2478757.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    40. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May; 45(5):318-25. Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. PMID: 17458864.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    41. Ovol1 represses its own transcription by competing with transcription activator c-Myb and by recruiting histone deacetylase activity. Nucleic Acids Res. 2007; 35(5):1687-97. Nair M, Bilanchone V, Ortt K, Sinha S, Dai X. PMID: 17311813; PMCID: PMC1865076.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    42. Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis. Biochim Biophys Acta. 2007 Jan; 1772(1):89-95. Teng A, Nair M, Wells J, Segre JA, Dai X. PMID: 17049212; PMCID: PMC1773004.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    43. Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol. 2006 Apr 24; 173(2):253-64. Nair M, Teng A, Bilanchone V, Agrawal A, Li B, Dai X. PMID: 16636146; PMCID: PMC2063816.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    44. The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Mar 01; 291(1):38-52. Mackay DR, Hu M, Li B, Rhéaume C, Dai X. PMID: 16423343; PMCID: PMC2891516.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    45. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005 Mar; 132(6):1463-73. Li B, Nair M, Mackay DR, Bilanchone V, Hu M, Fallahi M, Song H, Dai Q, Cohen PE, Dai X. PMID: 15716349; PMCID: PMC2898142.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    46. Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev. 2004 Oct; 14(5):485-91. Dai X, Segre JA. PMID: 15380238; PMCID: PMC2893379.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    47. Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics. 2004 Aug; 84(2):398-405. Li B, Mackay DR, Ma J, Dai X. PMID: 15234002; PMCID: PMC2893388.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    48. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. Genomics. 2002 Sep; 80(3):319-25. Li B, Dai Q, Li L, Nair M, Mackay DR, Dai X. PMID: 12213202; PMCID: PMC2893385.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    49. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6064-9. Li B, Mackay DR, Dai Q, Li TW, Nair M, Fallahi M, Schonbaum CP, Fantes J, Mahowald AP, Waterman ML, Fuchs E, Dai X. PMID: 11983900; PMCID: PMC122902.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
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