Dai, Xing

Title(s)Professor, Biological Chemistry
Phone(949) 824-3101
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Multiscale Models of Wound Cell Plasticity for Regeneration
    NIH/NIAMS U01AR073159Sep 1, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Mammary basal/stem cell plasticity and regulation
    NIH/NIGMS R01GM123731Sep 10, 2017 - May 31, 2021
    Role: Principal Investigator
    EMT regulators in Epidermal Morphogenesis
    NIH/NIAMS R56AR064532Sep 1, 2015 - Aug 31, 2016
    Role: Principal Investigator
    Control of epithelial plasticity and differentiation in hair follicle stem/progenitor cells
    NIH/NIAMS R01AR068074Jul 22, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Chromatin Regulation of Epithelial Progenitor Cell Self-Renewal by Pygo2
    NIH/NIGMS R01GM083089Jul 17, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Movo in embryonic development and skin differentiation
    NIH/NIAMS K02AR051482Jul 12, 2004 - Apr 30, 2009
    Role: Principal Investigator
    Role of Ovol Genes in Epidermal Development
    NIH/NIAMS R01AR047320Dec 1, 2000 - Jul 31, 2012
    Role: Principal Investigator
    NIH/NIAMS F32AR008456Mar 24, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sha Y, Haensel D, Gutierrez G, Du H, Dai X, Nie Q. Intermediate cell states in epithelial-to-mesenchymal transition. Phys Biol. 2019 01 18; 16(2):021001. PMID: 30560804.
      View in: PubMed
    2. Haensel D, Sun P, MacLean AL, Ma X, Zhou Y, Stemmler MP, Brabletz S, Berx G, Plikus MV, Nie Q, Brabletz T, Dai X. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO Rep. 2019 Jan; 20(1). PMID: 30413481.
      View in: PubMed
    3. Haensel D, McNeil MA, Dai X. Ex Vivo Imaging and Genetic Manipulation of Mouse Hair Follicle Bulge Stem Cells. Methods Mol Biol. 2018 Feb 25. PMID: 29478134.
      View in: PubMed
    4. Dai X, Medzhitov R. Inflammation: Memory beyond immunity. Nature. 2017 10 26; 550(7677):460-461. PMID: 29045392.
      View in: PubMed
    5. Haensel D, Dai X. Epithelial-to-mesenchymal transition in cutaneous wound healing: Where we are and where we are heading. Dev Dyn. 2018 03; 247(3):473-480. PMID: 28795450.
      View in: PubMed
    6. Lee B, Watanabe K, Haensel D, Sui JY, Dai X. Overexpression of Transcription Factor Ovol2 in Epidermal Progenitor Cells Results in Skin Blistering. J Invest Dermatol. 2017 08; 137(8):1805-1808. PMID: 28457910.
      View in: PubMed
    7. Hong T, Watanabe K, Ta CH, Villarreal-Ponce A, Nie Q, Dai X. An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States. PLoS Comput Biol. 2015 Nov; 11(11):e1004569. PMID: 26554584; PMCID: PMC4640575.
    8. Gord A, Holmes WR, Dai X, Nie Q. Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation. J R Soc Interface. 2014 Oct 06; 11(99). PMID: 25100322; PMCID: PMC4233746.
    9. Salmans ML, Yu Z, Watanabe K, Cam E, Sun P, Smyth P, Dai X, Andersen B. The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis. PLoS Genet. 2014 Jul; 10(7):e1004520. PMID: 25079073; PMCID: PMC4117441.
    10. Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X. Pygo2 regulates ß-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10215-20. PMID: 24982158; PMCID: PMC4104891.
    11. Lee B, Villarreal-Ponce A, Fallahi M, Ovadia J, Sun P, Yu QC, Ito S, Sinha S, Nie Q, Dai X. Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell. 2014 Apr 14; 29(1):47-58. PMID: 24735878; PMCID: PMC4153751.
    12. Watanabe K, Villarreal-Ponce A, Sun P, Salmans ML, Fallahi M, Andersen B, Dai X. Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor. Dev Cell. 2014 Apr 14; 29(1):59-74. PMID: 24735879; PMCID: PMC4062651.
    13. Watanabe K, Biesinger J, Salmans ML, Roberts BS, Arthur WT, Cleary M, Andersen B, Xie X, Dai X. Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer. PLoS One. 2014; 9(3):e92317. PMID: 24651522; PMCID: PMC3961325.
    14. Gu B, Watanabe K, Sun P, Fallahi M, Dai X. Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. Cell Stem Cell. 2013 Jul 03; 13(1):48-61. PMID: 23684539; PMCID: PMC3703489.
    15. Lee B, Dai X. Transcriptional control of epidermal stem cells. Adv Exp Med Biol. 2013; 786:157-73. PMID: 23696356.
      View in: PubMed
    16. Lee B, Geyfman M, Andersen B, Dai X. Analysis of gene expression in skin using laser capture microdissection. Methods Mol Biol. 2013; 989:109-17. PMID: 23483391.
      View in: PubMed
    17. Gu B, Watanabe K, Dai X. Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Cell Cycle. 2012 Jan 01; 11(1):79-87. PMID: 22186018; PMCID: PMC3272233.
    18. Watanabe K, Dai X. A WNTer revisit: new faces of ß-catenin and TCFs in pluripotency. Sci Signal. 2011 Sep 27; 4(193):pe41. PMID: 21971038.
      View in: PubMed
    19. Watanabe K, Dai X. Winning WNT: race to Wnt signaling inhibitors. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):5929-30. PMID: 21451134; PMCID: PMC3076855.
    20. Gu B, Watanabe K, Dai X. Epithelial stem cells: an epigenetic and Wnt-centric perspective. J Cell Biochem. 2010 Aug 15; 110(6):1279-87. PMID: 20564229; PMCID: PMC2923477.
    21. Christley S, Lee B, Dai X, Nie Q. Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms. BMC Syst Biol. 2010 Aug 09; 4:107. PMID: 20696053; PMCID: PMC2936904.
    22. Wells J, Dai X. Using siRNA knockdown in HaCaT cells to study transcriptional control of epidermal proliferation potential. Methods Mol Biol. 2010; 585:107-25. PMID: 19908000.
      View in: PubMed
    23. Sun P, Yuan Y, Li A, Li B, Dai X. Cytokeratin expression during mouse embryonic and early postnatal mammary gland development. Histochem Cell Biol. 2010 Feb; 133(2):213-21. PMID: 19937336; PMCID: PMC2807942.
    24. Wells J, Lee B, Cai AQ, Karapetyan A, Lee WJ, Rugg E, Sinha S, Nie Q, Dai X. Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1. J Biol Chem. 2009 Oct 16; 284(42):29125-35. PMID: 19700410; PMCID: PMC2781457.
    25. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, Li B, Dai X. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009 Jun 01; 185(5):811-26. PMID: 19487454; PMCID: PMC2711593.
    26. Nair M, Nagamori I, Sun P, Mishra DP, Rhéaume C, Li B, Sassone-Corsi P, Dai X. Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Dev Biol. 2008 Aug 15; 320(2):446-55. PMID: 18614164; PMCID: PMC2553271.
    27. Jessen S, Gu B, Dai X. Pygopus and the Wnt signaling pathway: a diverse set of connections. Bioessays. 2008 May; 30(5):448-56. PMID: 18404694.
      View in: PubMed
    28. Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M. Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15; 318(2):224-35. PMID: 18452912; PMCID: PMC2478757.
    29. Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May; 45(5):318-25. PMID: 17458864.
      View in: PubMed
    30. Nair M, Bilanchone V, Ortt K, Sinha S, Dai X. Ovol1 represses its own transcription by competing with transcription activator c-Myb and by recruiting histone deacetylase activity. Nucleic Acids Res. 2007; 35(5):1687-97. PMID: 17311813; PMCID: PMC1865076.
    31. Teng A, Nair M, Wells J, Segre JA, Dai X. Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis. Biochim Biophys Acta. 2007 Jan; 1772(1):89-95. PMID: 17049212; PMCID: PMC1773004.
    32. Nair M, Teng A, Bilanchone V, Agrawal A, Li B, Dai X. Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol. 2006 Apr 24; 173(2):253-64. PMID: 16636146; PMCID: PMC2063816.
    33. Mackay DR, Hu M, Li B, Rhéaume C, Dai X. The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Mar 01; 291(1):38-52. PMID: 16423343; PMCID: PMC2891516.
    34. Li B, Nair M, Mackay DR, Bilanchone V, Hu M, Fallahi M, Song H, Dai Q, Cohen PE, Dai X. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005 Mar; 132(6):1463-73. PMID: 15716349; PMCID: PMC2898142.
    35. Dai X, Segre JA. Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev. 2004 Oct; 14(5):485-91. PMID: 15380238; PMCID: PMC2893379.
    36. Li B, Mackay DR, Ma J, Dai X. Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics. 2004 Aug; 84(2):398-405. PMID: 15234002; PMCID: PMC2893388.
    37. Li B, Dai Q, Li L, Nair M, Mackay DR, Dai X. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. Genomics. 2002 Sep; 80(3):319-25. PMID: 12213202.
      View in: PubMed
    38. Li B, Mackay DR, Dai Q, Li TW, Nair M, Fallahi M, Schonbaum CP, Fantes J, Mahowald AP, Waterman ML, Fuchs E, Dai X. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6064-9. PMID: 11983900.
      View in: PubMed