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Xing Dai

Title(s)Professor, Biological Chemistry
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-3101
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    Collapse Research 
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    Multiscale Models of Wound Cell Plasticity for Regeneration
    NIH/NIAMS U01AR073159Sep 1, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Mammary basal/stem cell plasticity and regulation
    NIH/NIGMS R01GM123731Sep 10, 2017 - May 31, 2021
    Role: Principal Investigator
    EMT regulators in Epidermal Morphogenesis
    NIH/NIAMS R56AR064532Sep 1, 2015 - Aug 31, 2016
    Role: Principal Investigator
    Control of epithelial plasticity and differentiation in hair follicle stem/progenitor cells
    NIH/NIAMS R01AR068074Jul 22, 2015 - Jun 30, 2020
    Role: Principal Investigator
    Chromatin Regulation of Epithelial Progenitor Cell Self-Renewal by Pygo2
    NIH/NIGMS R01GM083089Jul 17, 2009 - Jun 30, 2011
    Role: Principal Investigator
    Movo in embryonic development and skin differentiation
    NIH/NIAMS K02AR051482Jul 12, 2004 - Apr 30, 2009
    Role: Principal Investigator
    Role of Ovol Genes in Epidermal Development
    NIH/NIAMS R01AR047320Aug 15, 2001 - Jul 31, 2012
    Role: Principal Investigator
    LEF 1 AND HAIR FOLLICLE MORPHOGENESIS
    NIH/NIAMS F32AR008456Jan 1, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics. Cell Rep. 2020 Mar 17; 30(11):3932-3947.e6. Haensel D, Jin S, Sun P, Cinco R, Dragan M, Nguyen Q, Cang Z, Gong Y, Vu R, MacLean AL, Kessenbrock K, Gratton E, Nie Q, Dai X. PMID: 32187560.
      View in: PubMed   Mentions: 2     Fields:    
    2. Intermediate cell states in epithelial-to-mesenchymal transition. Phys Biol. 2019 01 18; 16(2):021001. Sha Y, Haensel D, Gutierrez G, Du H, Dai X, Nie Q. PMID: 30560804.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Ex Vivo Imaging and Genetic Manipulation of Mouse Hair Follicle Bulge Stem Cells. Methods Mol Biol. 2019; 1879:15-29. Haensel D, McNeil MA, Dai X. PMID: 29478134.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation. EMBO Rep. 2019 01; 20(1). Haensel D, Sun P, MacLean AL, Ma X, Zhou Y, Stemmler MP, Brabletz S, Berx G, Plikus MV, Nie Q, Brabletz T, Dai X. PMID: 30413481.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Inflammation: Memory beyond immunity. Nature. 2017 10 26; 550(7677):460-461. Dai X, Medzhitov R. PMID: 29045392.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Epithelial-to-mesenchymal transition in cutaneous wound healing: Where we are and where we are heading. Dev Dyn. 2018 03; 247(3):473-480. Haensel D, Dai X. PMID: 28795450.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    7. Overexpression of Transcription Factor Ovol2 in Epidermal Progenitor Cells Results in Skin Blistering. J Invest Dermatol. 2017 08; 137(8):1805-1808. Lee B, Watanabe K, Haensel D, Sui JY, Dai X. PMID: 28457910.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States. PLoS Comput Biol. 2015 Nov; 11(11):e1004569. Hong T, Watanabe K, Ta CH, Villarreal-Ponce A, Nie Q, Dai X. PMID: 26554584.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    9. Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation. J R Soc Interface. 2014 Oct 06; 11(99). Gord A, Holmes WR, Dai X, Nie Q. PMID: 25100322.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    10. The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis. PLoS Genet. 2014 Jul; 10(7):e1004520. Salmans ML, Yu Z, Watanabe K, Cam E, Sun P, Smyth P, Dai X, Andersen B. PMID: 25079073.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. Pygo2 regulates ß-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10215-20. Sun P, Watanabe K, Fallahi M, Lee B, Afetian ME, Rheaume C, Wu D, Horsley V, Dai X. PMID: 24982158.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Transcriptional mechanisms link epithelial plasticity to adhesion and differentiation of epidermal progenitor cells. Dev Cell. 2014 Apr 14; 29(1):47-58. Lee B, Villarreal-Ponce A, Fallahi M, Ovadia J, Sun P, Yu QC, Ito S, Sinha S, Nie Q, Dai X. PMID: 24735878.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    13. Mammary morphogenesis and regeneration require the inhibition of EMT at terminal end buds by Ovol2 transcriptional repressor. Dev Cell. 2014 Apr 14; 29(1):59-74. Watanabe K, Villarreal-Ponce A, Sun P, Salmans ML, Fallahi M, Andersen B, Dai X. PMID: 24735879.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    14. Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer. PLoS One. 2014; 9(3):e92317. Watanabe K, Biesinger J, Salmans ML, Roberts BS, Arthur WT, Cleary M, Andersen B, Xie X, Dai X. PMID: 24651522.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    15. Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells. Cell Stem Cell. 2013 Jul 03; 13(1):48-61. Gu B, Watanabe K, Sun P, Fallahi M, Dai X. PMID: 23684539.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    16. Transcriptional control of epidermal stem cells. Adv Exp Med Biol. 2013; 786:157-73. Lee B, Dai X. PMID: 23696356.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. Analysis of gene expression in skin using laser capture microdissection. Methods Mol Biol. 2013; 989:109-17. Lee B, Geyfman M, Andersen B, Dai X. PMID: 23483391.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    18. Pygo2 regulates histone gene expression and H3 K56 acetylation in human mammary epithelial cells. Cell Cycle. 2012 Jan 01; 11(1):79-87. Gu B, Watanabe K, Dai X. PMID: 22186018.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    19. A WNTer revisit: new faces of ß-catenin and TCFs in pluripotency. Sci Signal. 2011 Sep 27; 4(193):pe41. Watanabe K, Dai X. PMID: 21971038.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    20. Winning WNT: race to Wnt signaling inhibitors. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):5929-30. Watanabe K, Dai X. PMID: 21451134.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    21. Epithelial stem cells: an epigenetic and Wnt-centric perspective. J Cell Biochem. 2010 Aug 15; 110(6):1279-87. Gu B, Watanabe K, Dai X. PMID: 20564229.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    22. Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms. BMC Syst Biol. 2010 Aug 09; 4:107. Christley S, Lee B, Dai X, Nie Q. PMID: 20696053.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    23. Using siRNA knockdown in HaCaT cells to study transcriptional control of epidermal proliferation potential. Methods Mol Biol. 2010; 585:107-25. Wells J, Dai X. PMID: 19908000.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Cytokeratin expression during mouse embryonic and early postnatal mammary gland development. Histochem Cell Biol. 2010 Feb; 133(2):213-21. Sun P, Yuan Y, Li A, Li B, Dai X. PMID: 19937336.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    25. Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1. J Biol Chem. 2009 Oct 16; 284(42):29125-35. Wells J, Lee B, Cai AQ, Karapetyan A, Lee WJ, Rugg E, Sinha S, Nie Q, Dai X. PMID: 19700410.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    26. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009 Jun 01; 185(5):811-26. Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, Li B, Dai X. PMID: 19487454.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    27. Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation. Dev Biol. 2008 Aug 15; 320(2):446-55. Nair M, Nagamori I, Sun P, Mishra DP, Rhéaume C, Li B, Sassone-Corsi P, Dai X. PMID: 18614164.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    28. Pygopus and the Wnt signaling pathway: a diverse set of connections. Bioessays. 2008 May; 30(5):448-56. Jessen S, Gu B, Dai X. PMID: 18404694.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    29. Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation. Dev Biol. 2008 Jun 15; 318(2):224-35. Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M. PMID: 18452912.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    30. Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2. Genesis. 2007 May; 45(5):318-25. Li B, Rhéaume C, Teng A, Bilanchone V, Munguia JE, Hu M, Jessen S, Piccolo S, Waterman ML, Dai X. PMID: 17458864.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    31. Ovol1 represses its own transcription by competing with transcription activator c-Myb and by recruiting histone deacetylase activity. Nucleic Acids Res. 2007; 35(5):1687-97. Nair M, Bilanchone V, Ortt K, Sinha S, Dai X. PMID: 17311813.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    32. Strain-dependent perinatal lethality of Ovol1-deficient mice and identification of Ovol2 as a downstream target of Ovol1 in skin epidermis. Biochim Biophys Acta. 2007 Jan; 1772(1):89-95. Teng A, Nair M, Wells J, Segre JA, Dai X. PMID: 17049212.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    33. Ovol1 regulates the growth arrest of embryonic epidermal progenitor cells and represses c-myc transcription. J Cell Biol. 2006 Apr 24; 173(2):253-64. Nair M, Teng A, Bilanchone V, Agrawal A, Li B, Dai X. PMID: 16636146.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    34. The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Mar 01; 291(1):38-52. Mackay DR, Hu M, Li B, Rhéaume C, Dai X. PMID: 16423343.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    35. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005 Mar; 132(6):1463-73. Li B, Nair M, Mackay DR, Bilanchone V, Hu M, Fallahi M, Song H, Dai Q, Cohen PE, Dai X. PMID: 15716349.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    36. Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev. 2004 Oct; 14(5):485-91. Dai X, Segre JA. PMID: 15380238.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    37. Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. Genomics. 2004 Aug; 84(2):398-405. Li B, Mackay DR, Ma J, Dai X. PMID: 15234002.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    38. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. Genomics. 2002 Sep; 80(3):319-25. Li B, Dai Q, Li L, Nair M, Mackay DR, Dai X. PMID: 12213202.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    39. The LEF1/beta -catenin complex activates movo1, a mouse homolog of Drosophila ovo required for epidermal appendage differentiation. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6064-9. Li B, Mackay DR, Dai Q, Li TW, Nair M, Fallahi M, Schonbaum CP, Fantes J, Mahowald AP, Waterman ML, Fuchs E, Dai X. PMID: 11983900.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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