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Monuki, Edwin S

Title(s)Professor, Pathology
Phone(949) 824-9604
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    Collapse Research 
    Collapse Research Activities and Funding
    Human choroid plexus epithelial cells derived from APOE isogenic iPSCs
    NIH/NIA R21AG064640Aug 1, 2019 - Feb 28, 2021
    Role: Principal Investigator
    2017 APSA West Regional Conference
    NIH/NIGMS R13GM126800Sep 19, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Developing Choroid Plexus-Based Tools and Drug Screens
    NIH/NIMH R21MH109036Jul 1, 2016 - Jun 30, 2018
    Role: Principal Investigator
    NRSA Training Core
    NIH/NCATS TL1TR001415Aug 15, 2015 - Jun 30, 2024
    Role: Co-Principal Investigator
    The Morphogen and Selector Gene Network in the Dorsal Telencephalic Midline
    NIH/NINDS R01NS064587Sep 29, 2008 - Mar 31, 2013
    Role: Principal Investigator
    Dorsal Signals in the Developing Telencephalon
    NIH/NINDS K02NS053511Jan 1, 2006 - Dec 31, 2010
    Role: Principal Investigator
    Morphogen Gradients in Microfluidic Cultures
    NIH/NIMH R21MH075059Jul 20, 2005 - May 31, 2008
    Role: Principal Investigator
    THE ROLE OF LHX2 IN CEREBRAL CORTICAL DEVELOPMENT
    NIH/NIMH K08MH002029Jan 5, 2001 - Dec 31, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Farzaneh T, Wang B, Clark N, Eade-Viele C, Kelner J, Rodgers J, Sempa G, Detweiler N, Kasmarek T, Lee T, Zhao X, Monuki ES, Rezk SA. Crucial role for pathology residents in laboratory self-inspection, a single Institute's experience. Pract Lab Med. 2019 Aug; 16:e00123. PMID: 31193900.
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    2. Ochaba J, Fote G, Kachemov M, Thein S, Yeung SY, Lau AL, Hernandez S, Lim RG, Casale M, Neel MJ, Monuki ES, Reidling J, Housman DE, Thompson LM, Steffan JS. IKKß slows Huntington's disease progression in R6/1 mice. Proc Natl Acad Sci U S A. 2019 May 28; 116(22):10952-10961. PMID: 31088970.
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    3. Lallai V, Grimes N, Fowler JP, Sequeira PA, Cartagena P, Limon A, Coutts M, Monuki ES, Bunney W, Demuro A, Fowler CD. Nicotine Acts on Cholinergic Signaling Mechanisms to Directly Modulate Choroid Plexus Function. eNeuro. 2019 Mar-Apr; 6(2). PMID: 31119189.
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    4. Yale AR, Nourse JL, Lee KR, Ahmed SN, Arulmoli J, Jiang AYL, McDonnell LP, Botten GA, Lee AP, Monuki ES, Demetriou M, Flanagan LA. Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells. Stem Cell Reports. 2018 10 09; 11(4):869-882. PMID: 30197120.
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    5. Johnson BA, Coutts M, Vo HM, Hao X, Fatima N, Rivera MJ, Sims RJ, Neel MJ, Kang YJ, Monuki ES. Accurate, strong, and stable reporting of choroid plexus epithelial cells in transgenic mice using a human transthyretin BAC. Fluids Barriers CNS. 2018 Aug 16; 15(1):22. PMID: 30111340.
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    6. Fiandaca MS, Mapstone M, Connors E, Jacobson M, Monuki ES, Malik S, Macciardi F, Federoff HJ. Systems healthcare: a holistic paradigm for tomorrow. BMC Syst Biol. 2017 Dec 19; 11(1):142. PMID: 29258513.
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    7. Monahan K, Schieren I, Cheung J, Mumbey-Wafula A, Monuki ES, Lomvardas S. Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons. Elife. 2017 09 21; 6. PMID: 28933695.
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    8. Piltti KM, Funes GM, Avakian SN, Salibian AA, Huang KI, Carta K, Kamei N, Flanagan LA, Monuki ES, Uchida N, Cummings BJ, Anderson AJ. Increasing Human Neural Stem Cell Transplantation Dose Alters Oligodendroglial and Neuronal Differentiation after Spinal Cord Injury. Stem Cell Reports. 2017 06 06; 8(6):1534-1548. PMID: 28479305.
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    9. Marsh SE, Yeung ST, Torres M, Lau L, Davis JL, Monuki ES, Poon WW, Blurton-Jones M. HuCNS-SC Human NSCs Fail to Differentiate, Form Ectopic Clusters, and Provide No Cognitive Benefits in a Transgenic Model of Alzheimer's Disease. Stem Cell Reports. 2017 02 14; 8(2):235-248. PMID: 28199828.
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    10. Monuki ES, Anderson AJ, Blurton-Jones M, Cummings BJ. Response to StemCells Inc. Stem Cell Reports. 2017 02 14; 8(2):195-197. PMID: 28199827.
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    11. Watanabe M, Fung ES, Chan FB, Wong JS, Coutts M, Monuki ES. BMP4 acts as a dorsal telencephalic morphogen in a mouse embryonic stem cell culture system. Biol Open. 2016 Dec 15; 5(12):1834-1843. PMID: 27815243.
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    12. Zhang L, Shimizu D, Killeen JL, Honda SA, Lu D, Stanoyevitch A, Lin F, Wang B, Monuki ES, Carbone M. Serous carcinomatous component championed by heparin-binding EGF-like growth factor (HB-EGF) predisposing to metastasis and recurrence in stage I uterine malignant mixed mullerian tumor. Hum Pathol. 2016 07; 53:159-67. PMID: 26980026.
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    13. Krishnan R, Truong N, Gerges M, Stiewig M, Neel N, Ho-Nguyen K, Kummerfeld C, Alexander M, Spizzo T, Martin M, Foster CE, Monuki ES, Lakey JR. Impact of donor age and weaning status on pancreatic exocrine and endocrine tissue maturation in pigs. Xenotransplantation. 2015 Sep-Oct; 22(5):356-67. PMID: 26381493.
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    14. Lun MP, Monuki ES, Lehtinen MK. Development and functions of the choroid plexus-cerebrospinal fluid system. Nat Rev Neurosci. 2015 Aug; 16(8):445-57. PMID: 26174708.
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    15. Wang X, Hsi TC, Guerrero-Juarez CF, Pham K, Cho K, McCusker CD, Monuki ES, Cho KW, Gay DL, Plikus MV. Principles and mechanisms of regeneration in the mouse model for wound-induced hair follicle neogenesis. Regeneration (Oxf). 2015 Aug; 2(4):169-181. PMID: 26504521.
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    16. Hong T, Fung ES, Zhang L, Huynh G, Monuki ES, Nie Q. Semi-adaptive response and noise attenuation in bone morphogenetic protein signalling. J R Soc Interface. 2015 Jun 06; 12(107). PMID: 25972436.
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    17. Striedter GF, Srinivasan S, Monuki ES. Cortical folding: when, where, how, and why? Annu Rev Neurosci. 2015 Jul 08; 38:291-307. PMID: 25897870.
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    18. Barkho BZ, Monuki ES. Proliferation of cultured mouse choroid plexus epithelial cells. PLoS One. 2015; 10(3):e0121738. PMID: 25815836.
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    19. Lun MP, Johnson MB, Broadbelt KG, Watanabe M, Kang YJ, Chau KF, Springel MW, Malesz A, Sousa AM, Pletikos M, Adelita T, Adelita T, Calicchio ML, Zhang Y, Holtzman MJ, Lidov HG, Sestan N, Steen H, Monuki ES, Lehtinen MK. Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25; 35(12):4903-16. PMID: 25810521.
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    20. Mendez DC, Stover AE, Rangel AD, Brick DJ, Nethercott HE, Torres MA, Khalid O, Wong AM, Cooper JD, Jester JV, Monuki ES, McGuire C, Le SQ, Kan SH, Dickson PI, Schwartz PH. A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I. Mol Ther Methods Clin Dev. 2015; 2:14068. PMID: 26052536.
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    21. Chinn GA, Hirokawa KE, Chuang TM, Urbina C, Patel F, Fong J, Funatsu N, Monuki ES. Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice. Cereb Cortex. 2015 Sep; 25(9):2707-18. PMID: 24781987.
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    22. Wang RY, Monuki ES, Powers J, Schwartz PH, Watkins PA, Shi Y, Moser A, Shrier DA, Waterham HR, Nugent DJ, Abdenur JE. Effects of hematopoietic stem cell transplantation on acyl-CoA oxidase deficiency: a sibling comparison study. J Inherit Metab Dis. 2014 Sep; 37(5):791-9. PMID: 24619150.
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    23. Srinivasan S, Hu JS, Currle DS, Fung ES, Hayes WB, Lander AD, Monuki ES. A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain. PLoS Comput Biol. 2014 Feb; 10(2):e1003463. PMID: 24550718.
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    24. Shetty AS, Godbole G, Maheshwari U, Padmanabhan H, Chaudhary R, Muralidharan B, Hou PS, Monuki ES, Kuo HC, Rema V, Tole S. Lhx2 regulates a cortex-specific mechanism for barrel formation. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):E4913-21. PMID: 24262147.
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    25. Lehtinen MK, Bjornsson CS, Dymecki SM, Gilbertson RJ, Holtzman DM, Monuki ES. The choroid plexus and cerebrospinal fluid: emerging roles in development, disease, and therapy. J Neurosci. 2013 Nov 06; 33(45):17553-9. PMID: 24198345.
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    26. Gordon PJ, Yun S, Clark AM, Monuki ES, Murtaugh LC, Levine EM. Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina. J Neurosci. 2013 Jul 24; 33(30):12197-207. PMID: 23884928.
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    27. Watanabe M, Kang YJ, Davies LM, Meghpara S, Lau K, Chung CY, Kathiriya J, Hadjantonakis AK, Monuki ES. BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors. J Neurosci. 2012 Nov 07; 32(45):15934-45. PMID: 23136431.
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    28. Doan LT, Javier AL, Furr NM, Nguyen KL, Cho KW, Monuki ES. A Bmp reporter with ultrasensitive characteristics reveals that high Bmp signaling is not required for cortical hem fate. PLoS One. 2012; 7(9):e44009. PMID: 22984456.
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    29. Javier AL, Doan LT, Luong M, Reyes de Mochel NS, Sun A, Monuki ES, Cho KW. Bmp indicator mice reveal dynamic regulation of transcriptional response. PLoS One. 2012; 7(9):e42566. PMID: 22984405.
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    30. de Melo J, Miki K, Rattner A, Smallwood P, Zibetti C, Hirokawa K, Monuki ES, Campochiaro PA, Blackshaw S. Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4657-62. PMID: 22393024.
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    31. Subramanian L, Sarkar A, Shetty AS, Muralidharan B, Padmanabhan H, Piper M, Monuki ES, Bach I, Gronostajski RM, Richards LJ, Tole S. Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):E265-74. PMID: 21690374.
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    32. McGowan L, Kuo E, Martin A, Monuki ES, Striedter G. Species differences in early patterning of the avian brain. Evolution. 2011 Mar; 65(3):907-11. PMID: 20825476.
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    33. Chizhikov VV, Lindgren AG, Mishima Y, Roberts RW, Aldinger KA, Miesegaes GR, Currle DS, Monuki ES, Millen KJ. Lmx1a regulates fates and location of cells originating from the cerebellar rhombic lip and telencephalic cortical hem. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10725-30. PMID: 20498066.
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    34. Yun S, Saijoh Y, Hirokawa KE, Kopinke D, Murtaugh LC, Monuki ES, Levine EM. Lhx2 links the intrinsic and extrinsic factors that control optic cup formation. Development. 2009 Dec; 136(23):3895-906. PMID: 19906857.
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    35. Mutch CA, Funatsu N, Monuki ES, Chenn A. Beta-catenin signaling levels in progenitors influence the laminar cell fates of projection neurons. J Neurosci. 2009 Oct 28; 29(43):13710-9. PMID: 19864583.
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    36. Wang L, Lu J, Marchenko SA, Monuki ES, Flanagan LA, Lee AP. Dual frequency dielectrophoresis with interdigitated sidewall electrodes for microfluidic flow-through separation of beads and cells. Electrophoresis. 2009 Mar; 30(5):782-91. PMID: 19197906.
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    37. Matheu MP, Beeton C, Garcia A, Chi V, Rangaraju S, Safrina O, Monaghan K, Uemura MI, Li D, Pal S, de la Maza LM, Monuki E, Flügel A, Pennington MW, Parker I, Chandy KG, Cahalan MD. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17; 29(4):602-14. PMID: 18835197.
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    38. Hu JS, Doan LT, Currle DS, Paff M, Rheem JY, Schreyer R, Robert B, Monuki ES. Border formation in a Bmp gradient reduced to single dissociated cells. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3398-403. PMID: 18292231.
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    39. Doan L, Monuki ES. Rapid genotyping of mouse tissue using Sigma's Extract-N-Amp Tissue PCR Kit. J Vis Exp. 2008 Jan 22; (11). PMID: 19066558.
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    40. Mangale VS, Hirokawa KE, Satyaki PR, Gokulchandran N, Chikbire S, Subramanian L, Shetty AS, Martynoga B, Paul J, Mai MV, Li Y, Flanagan LA, Tole S, Monuki ES. Lhx2 selector activity specifies cortical identity and suppresses hippocampal organizer fate. Science. 2008 Jan 18; 319(5861):304-9. PMID: 18202285.
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    41. Flanagan LA, Lu J, Wang L, Marchenko SA, Jeon NL, Lee AP, Monuki ES. Unique dielectric properties distinguish stem cells and their differentiated progeny. Stem Cells. 2008 Mar; 26(3):656-65. PMID: 18096719.
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    42. Su JS, Monuki ES. RNA extraction from neuroprecursor cells using the bio-rad total RNA kit. J Vis Exp. 2007; (9):405. PMID: 18989446.
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    43. Xu X, Mannik J, Kudryavtseva E, Lin KK, Flanagan LA, Spencer J, Soto A, Wang N, Lu Z, Yu Z, Monuki ES, Andersen B. Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells. Dev Biol. 2007 Dec 15; 312(2):484-500. PMID: 17991461.
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    44. Chung BG, Park JW, Hu JS, Huang C, Monuki ES, Jeon NL. A hybrid microfluidic-vacuum device for direct interfacing with conventional cell culture methods. BMC Biotechnol. 2007 Sep 20; 7:60. PMID: 17883868.
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    45. Monuki ES. The morphogen signaling network in forebrain development and holoprosencephaly. J Neuropathol Exp Neurol. 2007 Jul; 66(7):566-75. PMID: 17620982.
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    46. Wang L, Flanagan LA, Monuki E, Jeon NL, Lee AP. Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry. Lab Chip. 2007 Sep; 7(9):1114-20. PMID: 17713608.
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    47. Currle DS, Monuki ES. Flash freezing and cryosectioning E12.5 mouse brain. J Vis Exp. 2007; (4):198. PMID: 18979003.
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    48. Currle DS, Hu JS, Kolski-Andreaco A, Monuki ES. Culture of mouse neural stem cell precursors. J Vis Exp. 2007 Feb 25; (2):152. PMID: 18830426.
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    49. Currle S, Kolski-Andreaco A, Monuki ES. Mouse dorsal forebrain explant isolation. J Vis Exp. 2007 Jan 30; (2):135. PMID: 18830423.
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    50. Currle DS, Kolski-Andreaco A, Monuki ES. Growth factor-coated bead placement on dorsal forebrain explants. J Vis Exp. 2007 Jan 30; (2):134. PMID: 18830433.
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    51. Gibbs WN, Monuki ES, Linskey ME, Hasso AN. Pituicytoma: diagnostic features on selective carotid angiography and MR imaging. AJNR Am J Neuroradiol. 2006 Sep; 27(8):1639-42. PMID: 16971602.
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    52. Cheng X, Hsu CM, Currle DS, Hu JS, Barkovich AJ, Monuki ES. Central roles of the roof plate in telencephalic development and holoprosencephaly. J Neurosci. 2006 Jul 19; 26(29):7640-9. PMID: 16855091.
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    53. Chizhikov VV, Lindgren AG, Currle DS, Rose MF, Monuki ES, Millen KJ. The roof plate regulates cerebellar cell-type specification and proliferation. Development. 2006 Aug; 133(15):2793-804. PMID: 16790481.
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    54. Flanagan LA, Rebaza LM, Derzic S, Schwartz PH, Monuki ES. Regulation of human neural precursor cells by laminin and integrins. J Neurosci Res. 2006 Apr; 83(5):845-56. PMID: 16477652.
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    55. Currle DS, Cheng X, Hsu CM, Monuki ES. Direct and indirect roles of CNS dorsal midline cells in choroid plexus epithelia formation. Development. 2005 Aug; 132(15):3549-59. PMID: 15975937.
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    56. Chung BG, Flanagan LA, Rhee SW, Schwartz PH, Lee AP, Monuki ES, Jeon NL. Human neural stem cell growth and differentiation in a gradient-generating microfluidic device. Lab Chip. 2005 Apr; 5(4):401-6. PMID: 15791337.
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    57. Nieto M, Monuki ES, Tang H, Imitola J, Haubst N, Khoury SJ, Cunningham J, Gotz M, Walsh CA. Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex. J Comp Neurol. 2004 Nov 08; 479(2):168-80. PMID: 15452856.
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    58. Collins J, Flanagan L, Jeon N, Monuki E, Lee AP. Biochemical, biomolecular and cellular sensing in microfluidics using flow induced admittance spectra. Conf Proc IEEE Eng Med Biol Soc. 2004; 4:2565-7. PMID: 17270797.
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    59. Lin G, Wu VI, Hainley RE, Flanagan LA, Monuki ES, Tang WC. Development of a MEMS microsystem to study the effect of mechanical tension on cerebral cortex neurogenesis. Conf Proc IEEE Eng Med Biol Soc. 2004; 4:2607-10. PMID: 17270809.
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    60. Luong MX, van der Meijden CM, Xing D, Hesselton R, Monuki ES, Jones SN, Lian JB, Stein JL, Stein GS, Neufeld EJ, van Wijnen AJ. Genetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertility. Mol Cell Biol. 2002 Mar; 22(5):1424-37. PMID: 11839809.
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    61. Monuki ES, Porter FD, Walsh CA. Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway. Neuron. 2001 Nov 20; 32(4):591-604. PMID: 11719201.
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    62. Monuki ES, Walsh CA. Mechanisms of cerebral cortical patterning in mice and humans. Nat Neurosci. 2001 Nov; 4 Suppl:1199-206. PMID: 11687830.
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    63. Monuki ES, Walsh CA. Proto-mapping the areas of cerebral cortex: transcription factors make the grade. Nat Neurosci. 2000 Jul; 3(7):640-1. PMID: 10862691.
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    64. Monuki ES, Kuhn R, Lemke G. Cell-specific action and mutable structure of a transcription factor effector domain. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):9978-82. PMID: 8234344.
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    65. Bögler O, Entwistle A, Kuhn R, Monuki E, Lemke G, Noble M. Single cell analysis of the expression of a nuclear protein, SCIP, by fluorescent immunohistochemistry visualized with confocal microscopy. Histochem J. 1993 Oct; 25(10):746-61. PMID: 7506703.
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    66. Monuki ES, Kuhn R, Lemke G. Repression of the myelin P0 gene by the POU transcription factor SCIP. Mech Dev. 1993 Jul; 42(1-2):15-32. PMID: 7690239.
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    67. Collarini EJ, Kuhn R, Marshall CJ, Monuki ES, Lemke G, Richardson WD. Down-regulation of the POU transcription factor SCIP is an early event in oligodendrocyte differentiation in vitro. Development. 1992 Sep; 116(1):193-200. PMID: 1483387.
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    68. Kuhn R, Monuki ES, Lemke G. The gene encoding the transcription factor SCIP has features of an expressed retroposon. Mol Cell Biol. 1991 Sep; 11(9):4642-50. PMID: 1652060.
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    69. Collarini EJ, Pringle N, Mudhar H, Stevens G, Kuhn R, Monuki ES, Lemke G, Richardson WD. Growth factors and transcription factors in oligodendrocyte development. J Cell Sci Suppl. 1991; 15:117-23. PMID: 1668594.
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    70. Lemke G, Kuhn R, Monuki ES, Weinmaster G. Expression and activity of the transcription factor SCIP during glial differentiation and myelination. Ann N Y Acad Sci. 1991; 633:189-95. PMID: 1665030.
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    71. Monuki ES, Kuhn R, Weinmaster G, Trapp BD, Lemke G. Expression and activity of the POU transcription factor SCIP. Science. 1990 Sep 14; 249(4974):1300-3. PMID: 1975954.
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    72. Lemke G, Kuhn R, Monuki ES, Weinmaster G. Transcriptional controls underlying Schwann cell differentiation and myelination. Ann N Y Acad Sci. 1990; 605:248-53. PMID: 2176442.
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    73. Monuki ES, Weinmaster G, Kuhn R, Lemke G. SCIP: a glial POU domain gene regulated by cyclic AMP. Neuron. 1989 Dec; 3(6):783-93. PMID: 2561978.
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