Scott Atwood

Title(s)Assistant Professor, Developmental & Cell Biology
SchoolSchool of Biological Sciences
Address4238 McGaugh Hall
Zot 2300
Irvine CA 92697
Phone(949) 824-4346
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    Collapse Research 
    Collapse Research Activities and Funding
    Phosphorylation-dependent regulation of GLI transcription factors
    NIH R01CA237563Apr 11, 2019 - Mar 31, 2024
    Role: Principal Investigator
    aPKC function in Hedgehog signaling and basal cell carcinoma
    NIH R00CA176847Feb 11, 2014 - Oct 31, 2018
    Role: Principal Investigator
    aPKC function in Hedgehog signaling and basal cell carcinoma
    NIH K99CA176847Feb 11, 2014 - Jan 31, 2016
    Role: Principal Investigator
    MIM regulates Shh target gene expression in tumors
    NIH F32CA142087Feb 1, 2010 - Jan 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Applying Multiomics to Basosquamous Carcinoma. J Invest Dermatol. 2024 Feb 21. Long GR, Kurdian AI, Atwood SX. PMID: 38385917.
      View in: PubMed   Mentions:    Fields:    
    2. Leveraging gene correlations in single cell transcriptomic data. bioRxiv. 2023 Nov 01. Silkwood K, Dollinger E, Gervin J, Atwood S, Nie Q, Lander AD. PMID: 36993765; PMCID: PMC10055147.
      View in: PubMed   Mentions:
    3. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury. Cell Rep. 2023 09 26; 42(9):113121. Veniaminova NA, Jia YY, Hartigan AM, Huyge TJ, Tsai SY, Grachtchouk M, Nakagawa S, Dlugosz AA, Atwood SX, Wong SY. PMID: 37715952; PMCID: PMC10591672.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    4. Single-cell transcriptomics of human-skin-equivalent organoids. Cell Rep. 2023 05 30; 42(5):112511. Stabell AR, Lee GE, Jia Y, Wong KN, Wang S, Ling J, Nguyen SD, Sen GL, Nie Q, Atwood SX. PMID: 37195865; PMCID: PMC10348600.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury. bioRxiv. 2023 May 05. Veniaminova NA, Jia Y, Hartigan AM, Huyge TJ, Tsai SY, Grachtchouk M, Nakagawa S, Dlugosz AA, Atwood SX, Wong SY. PMID: 37205445; PMCID: PMC10187279.
      View in: PubMed   Mentions:
    6. Screening cell-cell communication in spatial transcriptomics via collective optimal transport. Nat Methods. 2023 02; 20(2):218-228. Cang Z, Zhao Y, Almet AA, Stabell A, Ramos R, Plikus MV, Atwood SX, Nie Q. PMID: 36690742; PMCID: PMC9911355.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    7. An Optimized Enzyme-Nucleobase Pair Enables In Vivo RNA Metabolic Labeling with Improved Cell-Specificity. Biochemistry. 2022 12 06; 61(23):2638-2642. Singha MK, Zimak J, Levine SR, Dai N, Hong C, Anaraki C, Gupta M, Halbrook CJ, Atwood SX, Spitale RC. PMID: 36383486; PMCID: PMC10149115.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1. Life Sci Alliance. 2022 11; 5(11). Bardwell AJ, Wu B, Sarin KY, Waterman ML, Atwood SX, Bardwell L. PMID: 35831023; PMCID: PMC9279676.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    9. Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment. Sci Adv. 2022 06 10; 8(23):eabm7981. Guerrero-Juarez CF, Lee GH, Liu Y, Wang S, Karikomi M, Sha Y, Chow RY, Nguyen TTL, Iglesias VS, Aasi S, Drummond ML, Nie Q, Sarin K, Atwood SX. PMID: 35687691; PMCID: PMC9187229.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    10. Exploiting Endogenous Enzymes for Cancer-Cell Selective Metabolic Labeling of RNA in Vivo. J Am Chem Soc. 2022 04 27; 144(16):7085-7088. Beasley S, Vandewalle A, Singha M, Nguyen K, England W, Tarapore E, Dai N, Corrêa IR, Atwood SX, Spitale RC. PMID: 35416650; PMCID: PMC10032647.
      View in: PubMed   Mentions: 4     Fields:    
    11. PI3K Promotes Basal Cell Carcinoma Growth Through Kinase-Induced p21 Degradation. Front Oncol. 2021; 11:668247. Chow RY, Jeon US, Levee TM, Kaur G, Cedeno DP, Doan LT, Atwood SX. PMID: 34268113; PMCID: PMC8276170.
      View in: PubMed   Mentions: 3  
    12. Fostering a healthy culture: Biological relevance of in vitro and ex vivo skin models. Exp Dermatol. 2021 03; 30(3):298-303. Atwood SX, Plikus MV. PMID: 33565670; PMCID: PMC8142902.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    13. MTOR promotes basal cell carcinoma growth through atypical PKC. Exp Dermatol. 2021 03; 30(3):358-366. Chow RY, Levee TM, Kaur G, Cedeno DP, Doan LT, Atwood SX. PMID: 33617094; PMCID: PMC9924159.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    14. OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia. J Invest Dermatol. 2021 06; 141(6):1542-1552. Sun P, Vu R, Dragan M, Haensel D, Gutierrez G, Nguyen Q, Greenberg E, Chen Z, Wu J, Atwood S, Pearlman E, Shi Y, Han W, Kessenbrock K, Dai X. PMID: 33333123; PMCID: PMC8532526.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    15. Divergent Resistance Mechanisms to Immunotherapy Explain Responses in Different Skin Cancers. Cancers (Basel). 2020 Oct 13; 12(10). Dollinger E, Bergman D, Zhou P, Atwood SX, Nie Q. PMID: 33065980; PMCID: PMC7599806.
      View in: PubMed   Mentions: 5  
    16. AP-1 and TGFß cooperativity drives non-canonical Hedgehog signaling in resistant basal cell carcinoma. Nat Commun. 2020 10 08; 11(1):5079. Yao CD, Haensel D, Gaddam S, Patel T, Atwood SX, Sarin KY, Whitson RJ, McKellar S, Shankar G, Aasi S, Rieger K, Oro AE. PMID: 33033234; PMCID: PMC7546632.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    17. Single cell transcriptomics of human epidermis identifies basal stem cell transition states. Nat Commun. 2020 08 25; 11(1):4239. Wang S, Drummond ML, Guerrero-Juarez CF, Tarapore E, MacLean AL, Stabell AR, Wu SC, Gutierrez G, That BT, Benavente CA, Nie Q, Atwood SX. PMID: 32843640; PMCID: PMC7447770.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    18. Defining the Genetics of Basosquamous Carcinoma. J Invest Dermatol. 2019 11; 139(11):2258-2260. Tarapore E, Atwood SX. PMID: 31648686.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma. J Invest Dermatol. 2019 07; 139(7):1439-1448. Kuonen F, Huskey NE, Shankar G, Jaju P, Whitson RJ, Rieger KE, Atwood SX, Sarin KY, Oro AE. PMID: 30707899; PMCID: PMC6591089.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    20. MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):E12407-E12416. Brown AS, Meera P, Altindag B, Chopra R, Perkins EM, Paul S, Scoles DR, Tarapore E, Magri J, Huang H, Jackson M, Shakkottai VG, Otis TS, Pulst SM, Atwood SX, Oro AE. PMID: 30530649; PMCID: PMC6310854.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    21. Actin polymerization controls cilia-mediated signaling. J Cell Biol. 2018 09 03; 217(9):3255-3266. Drummond ML, Li M, Tarapore E, Nguyen TTL, Barouni BJ, Cruz S, Tan KC, Oro AE, Atwood SX. PMID: 29945904; PMCID: PMC6122990.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    22. Illuminating Alternative Strategies to Treat Targeted Chemotherapy-Resistant Sporadic Basal Cell Carcinoma. J Invest Dermatol. 2018 05; 138(5):1017-1019. Nguyen TTL, Atwood SX. PMID: 29681387.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nat Med. 2018 03; 24(3):271-281. Whitson RJ, Lee A, Urman NM, Mirza A, Yao CY, Brown AS, Li JR, Shankar G, Fry MA, Atwood SX, Lee EY, Hollmig ST, Aasi SZ, Sarin KY, Scott MP, Epstein EH, Tang JY, Oro AE. PMID: 29400712; PMCID: PMC5839965.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    24. Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight. 2017 11 02; 2(21). Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE. PMID: 29093271; PMCID: PMC5752280.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    25. Cell-Selective Bioorthogonal Metabolic Labeling of RNA. J Am Chem Soc. 2017 02 15; 139(6):2148-2151. Nguyen K, Fazio M, Kubota M, Nainar S, Feng C, Li X, Atwood SX, Bredy TW, Spitale RC. PMID: 28139910.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    26. sm"FISH"ing for Hedgehog. J Invest Dermatol. 2017 01; 137(1):13-15. Drummond ML, Atwood SX. PMID: 28010757.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    27. Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions. PLoS One. 2016; 11(12):e0168031. Urman NM, Mirza A, Atwood SX, Whitson RJ, Sarin KY, Tang JY, Oro AE. PMID: 28030567; PMCID: PMC5193403.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma. JAMA Dermatol. 2016 Apr; 152(4):452-6. Ally MS, Ransohoff K, Sarin K, Atwood SX, Rezaee M, Bailey-Healy I, Kim J, Beachy PA, Chang AL, Oro A, Tang JY, Colevas AD. PMID: 26765315; PMCID: PMC4833646.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    29. Mutations in the Kinetochore Gene KNSTRN in Basal Cell Carcinoma. J Invest Dermatol. 2015 Dec; 135(12):3197-3200. Jaju PD, Nguyen CB, Mah AM, Atwood SX, Li J, Zia A, Chang ALS, Oro AE, Tang JY, Lee CS, Sarin KY. PMID: 26348826; PMCID: PMC4747638.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. Cancer Res. 2015 Sep 01; 75(17):3623-35. Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA. PMID: 26130651; PMCID: PMC4558230.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    31. Rolling the Genetic Dice: Neutral and Deleterious Smoothened Mutations in Drug-Resistant Basal Cell Carcinoma. J Invest Dermatol. 2015 Aug; 135(8):2138-2141. Atwood SX, Sarin KY, Li JR, Yao CY, Urman NM, Chang ALS, Tang JY, Oro AE. PMID: 25801792; PMCID: PMC4504757.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    32. Smoothened variants explain the majority of drug resistance in basal cell carcinoma. Cancer Cell. 2015 Mar 09; 27(3):342-53. Atwood SX, Sarin KY, Whitson RJ, Li JR, Kim G, Rezaee M, Ally MS, Kim J, Yao C, Chang AL, Oro AE, Tang JY. PMID: 25759020; PMCID: PMC4357167.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansCells
    33. Advanced treatment for basal cell carcinomas. Cold Spring Harb Perspect Med. 2014 Jul 01; 4(7):a013581. Atwood SX, Whitson RJ, Oro AE. PMID: 24985127; PMCID: PMC4066644.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    34. Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. Nat Med. 2014 Jul; 20(7):732-40. Tang Y, Gholamin S, Schubert S, Willardson MI, Lee A, Bandopadhayay P, Bergthold G, Masoud S, Nguyen B, Vue N, Balansay B, Yu F, Oh S, Woo P, Chen S, Ponnuswami A, Monje M, Atwood SX, Whitson RJ, Mitra S, Cheshier SH, Qi J, Beroukhim R, Tang JY, Wechsler-Reya R, Oro AE, Link BA, Bradner JE, Cho YJ. PMID: 24973920; PMCID: PMC4108909.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    35. "Atypical" regulation of Hedgehog-dependent cancers. Cancer Cell. 2014 Feb 10; 25(2):133-4. Atwood SX, Oro AE. PMID: 24525228; PMCID: PMC4024826.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    36. Identification of genes promoting skin youthfulness by genome-wide association study. J Invest Dermatol. 2014 Mar; 134(3):651-657. Chang ALS, Atzmon G, Bergman A, Brugmann S, Atwood SX, Chang HY, Barzilai N. PMID: 24037343; PMCID: PMC3923276.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    37. Surgical excision after neoadjuvant therapy with vismodegib for a locally advanced basal cell carcinoma and resistant basal carcinomas in Gorlin syndrome. JAMA Dermatol. 2013 May; 149(5):639-41. Chang AL, Atwood SX, Tartar DM, Oro AE. PMID: 23677114; PMCID: PMC4006072.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    38. "Patch"ing up our tumor signaling knowledge. J Invest Dermatol. 2013 May; 133(5):1131-3. Atwood SX, Whitson RJ, Oro AE. PMID: 23594533; PMCID: PMC4006018.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    39. Rapid genetic analysis of epithelial-mesenchymal signaling during hair regeneration. J Vis Exp. 2013 Feb 28; (72):e4344. Woo WM, Atwood SX, Zhen HH, Oro AE. PMID: 23486463; PMCID: PMC3622109.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    40. GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas. Nature. 2013 Feb 28; 494(7438):484-8. Atwood SX, Li M, Lee A, Tang JY, Oro AE. PMID: 23446420; PMCID: PMC3761364.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    41. Hedgehog pathway inhibition and the race against tumor evolution. J Cell Biol. 2012 Oct 15; 199(2):193-7. Atwood SX, Chang AL, Oro AE. PMID: 23071148; PMCID: PMC3471227.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    42. Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement. J Biol Chem. 2012 Jun 15; 287(25):21003-11. Graybill C, Wee B, Atwood SX, Prehoda KE. PMID: 22544755; PMCID: PMC3375524.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    43. Alcohol use and the management of multidrug-resistant tuberculosis in Tomsk, Russian Federation. Int J Tuberc Lung Dis. 2012 Jul; 16(7):891-6. Miller AC, Gelmanova IY, Keshavjee S, Atwood S, Yanova G, Mishustin S, Furin JJ, Shin SS. PMID: 22507895; PMCID: PMC8324013.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    44. Hepatotoxicity during treatment for multidrug-resistant tuberculosis: occurrence, management and outcome. Int J Tuberc Lung Dis. 2012 May; 16(5):596-603. Keshavjee S, Gelmanova IY, Shin SS, Mishustin SP, Andreev YG, Atwood S, Furin JJ, Miller A. PMID: 22410436.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    45. MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. Dev Cell. 2010 Aug 17; 19(2):270-83. Bershteyn M, Atwood SX, Woo WM, Li M, Oro AE. PMID: 20708589; PMCID: PMC3108505.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    46. aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division. Curr Biol. 2009 May 12; 19(9):723-9. Atwood SX, Prehoda KE. PMID: 19375318; PMCID: PMC2689075.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    47. Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. J Cell Sci. 2007 Sep 15; 120(Pt 18):3200-6. Atwood SX, Chabu C, Penkert RR, Doe CQ, Prehoda KE. PMID: 17726059; PMCID: PMC1988841.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
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