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Mahtab Jafari

Title(s)Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-0145
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    Botanicals, Mitochondrial Bioenergetics, and Aging Pathways
    NIH R21AT004987Apr 1, 2010 - Mar 31, 2013
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Iran: Attacking injured protestors and healthcare workers violates medical neutrality. BMJ. 2026 Feb 06; 392:s243. Jafari M, Alaei K, Abdi H, Kooschi A, Saidi RF. PMID: 41651548.
      View in: PubMed   Mentions:    Fields:    
    2. Violations of medical neutrality during protests in Iran. Lancet. 2026 Feb 14; 407(10529):672-673. Alaei A, Alaei K, Abdi H, Azari SA, Kooschi A, Mirzaei S, Saidi RF, Jafari M. PMID: 41628626.
      View in: PubMed   Mentions:    Fields:    
    3. The quality and safety of Rhodiola rosea supplements on the U.S. market: An analysis of biomarkers, heavy metals, and pesticide residues. PLoS One. 2026; 21(1):e0341070. Porwollik S, Jafari M. PMID: 41544018; PMCID: PMC12810810.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsPHPublic Health
    4. Comparison of Mineral Levels in Blood and Hair Samples of Healthy Adults: Evaluating the Clinical Utility of Hair Mineral Analysis. Biol Trace Elem Res. 2026 Mar; 204(3):1915-1927. Shahverdian A, Torabzadeh S, Watts D, Porwollik S, Padilla M, Lee JS, Perez G, Jafari M. PMID: 41275064; PMCID: PMC12992362.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Dietary Supplement Safety in Older Adults: A Review of Published Case Reports. Sr Care Pharm. 2025 Jan 01; 40(1):32-49. Shahverdian A, Jafari M. PMID: 39747809.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Impact of Patient Personality on Adherence to Oral Anticancer Medications: An Opportunity? JMIR Cancer. 2024 10 30; 10:e57199. Jafari M, Shahverdian A, Sadigh G, Van Etten RA. PMID: 39475848; PMCID: PMC11561440.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Can an Online Course, Life101: Mental and Physical Self-Care, Improve the Well-Being of College Students? JMIR Med Educ. 2024 07 22; 10:e50111. Jafari M. PMID: 39041304; PMCID: PMC11284613.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    8. Angelica keiskei Impacts the Lifespan and Healthspan of Drosophila melanogaster in a Sex and Strain-Dependent Manner. Pharmaceuticals (Basel). 2023 May 12; 16(5). Jafari M, Schriner SE, Kil YS, Pham ST, Seo EK. PMID: 37242522; PMCID: PMC10222730.
      View in: PubMed   Mentions: 2  
    9. The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model. Sci Rep. 2022 06 22; 12(1):10581. Jafari M, Juanson Arabit JG, Courville R, Kiani D, Chaston JM, Nguyen CD, Jena N, Liu ZY, Tata P, Van Etten RA. PMID: 35732671; PMCID: PMC9217815.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    10. Editorial: Plant Foods and Dietary Supplements: Building Solid Foundations for Clinical Trials. Front Nutr. 2022; 9:881688. Sorkin BC, Murch SJ, Weaver CM, Jafari M. PMID: 35479736; PMCID: PMC9036084.
      View in: PubMed   Mentions: 3  
    11. COVID-19, stress and mental health: What students expect from academic institutions during a pandemic. J Am Coll Health. 2023 Oct; 71(7):1976-1983. Jafari M, De Roche M, Eshaghi MR. PMID: 34398699.
      View in: PubMed   Mentions: 1     Fields:    
    12. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 06 03; 4(1):685. Mohammadi MR, Rodriguez SM, Luong JC, Li S, Cao R, Alshetaiwi H, Lau H, Davtyan H, Jones MB, Jafari M, Kessenbrock K, Villalta SA, de Vos P, Zhao W, Lakey JRT. PMID: 34083739; PMCID: PMC8175379.
      View in: PubMed   Mentions: 26  Translation:HumansAnimalsCells
    13. Diet and Botanical Supplementation: Combination Therapy for Healthspan Improvement? Rejuvenation Res. 2021 Oct; 24(5):331-344. Rutledge GA, Phang HJ, Le MN, Bui L, Rose MR, Mueller LD, Jafari M. PMID: 32924860.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    14. High-performance Countercurrent Chromatography to Access Rhodiola rosea Influenza Virus Inhibiting Constituents. Planta Med. 2021 Aug; 87(10-11):818-826. Langeder J, Grienke U, Döring K, Jafari M, Ehrhardt C, Schmidtke M, Rollinger JM. PMID: 32781473.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    15. Improving natural product research translation: From source to clinical trial. FASEB J. 2020 01; 34(1):41-65. Sorkin BC, Kuszak AJ, Bloss G, Fukagawa NK, Hoffman FA, Jafari M, Barrett B, Brown PN, Bushman FD, Casper SJ, Chilton FH, Coffey CS, Ferruzzi MG, Hopp DC, Kiely M, Lakens D, MacMillan JB, Meltzer DO, Pahor M, Paul J, Pritchett-Corning K, Quinney SK, Rehermann B, Setchell KDR, Sipes NS, Stephens JM, Taylor DL, Tiriac H, Walters MA, Xi D, Zappalá G, Pauli GF. PMID: 31914647; PMCID: PMC7470648.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    16. Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer's Disease. Biomed Res Int. 2018; 2018:3570830. Pham HM, Xu A, Schriner SE, Sevrioukov EA, Jafari M. PMID: 30228985; PMCID: PMC6136480.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    17. Rhodiola rosea Improves Lifespan, Locomotion, and Neurodegeneration in a Drosophila melanogaster Model of Huntington's Disease. Biomed Res Int. 2018; 2018:6726874. Arabit JGJ, Elhaj R, Schriner SE, Sevrioukov EA, Jafari M. PMID: 29984244; PMCID: PMC6015705.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    18. The impact of Rhodiola rosea on the gut microbial community of Drosophila melanogaster. Gut Pathog. 2018; 10:12. Labachyan KE, Kiani D, Sevrioukov EA, Schriner SE, Jafari M. PMID: 29581730; PMCID: PMC5861609.
      View in: PubMed   Mentions: 9  
    19. A unique degree program for pre-pharmacy education: An undergraduate degree in pharmaceutical sciences. Curr Pharm Teach Learn. 2018 02; 10(2):243-251. Jafari M. PMID: 29706283.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells. Bioorg Med Chem Lett. 2017 07 15; 27(14):3065-3070. Kil YS, Park J, Jafari M, Woo HA, Seo EK. PMID: 28571822.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    21. Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities. Arch Pharm Res. 2017 Jun; 40(6):655-675. Kil YS, Pham ST, Seo EK, Jafari M. PMID: 28439780; PMCID: PMC7090720.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    22. Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster. Arch Insect Biochem Physiol. 2016 Dec; 93(4):210-221. Lopez TE, Pham HM, Nguyen BV, Tahmasian Y, Ramsden S, Coskun V, Schriner SE, Jafari M. PMID: 27696504; PMCID: PMC5121014.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    23. Extension of Drosophila Lifespan by Rhodiola rosea Depends on Dietary Carbohydrate and Caloric Content in a Simplified Diet. J Med Food. 2016 Mar; 19(3):318-23. Schriner SE, Coskun V, Hogan SP, Nguyen CT, Lopez TE, Jafari M. PMID: 26987024.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    24. The impact of green tea polyphenols on development and reproduction in Drosophila melanogaster. J Funct Foods. 2016 Jan 01; 20:556-566. Lopez TE, Pham HM, Barbour J, Tran P, Van Nguyen B, Hogan SP, Homo RL, Coskun V, Schriner SE, Jafari M. PMID: 26693252; PMCID: PMC4683606.
      View in: PubMed   Mentions: 10  
    25. Healthspan Pharmacology. Rejuvenation Res. 2015 Dec; 18(6):573-80. Jafari M. PMID: 26444965; PMCID: PMC4685493.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    26. Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities. J Nat Prod. 2015 Oct 23; 78(10):2481-7. Kil YS, Choi SK, Lee YS, Jafari M, Seo EK. PMID: 26431394.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    27. Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness. J Med Food. 2014 Dec; 17(12):1314-21. Lopez T, Schriner SE, Okoro M, Lu D, Chiang BT, Huey J, Jafari M. PMID: 25058464; PMCID: PMC4259189.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    28. Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico. Exp Gerontol. 2014 Dec; 60:220-30. Schriner SE, Kuramada S, Lopez TE, Truong S, Pham A, Jafari M. PMID: 25456850; PMCID: PMC4309393.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    29. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS One. 2013; 8(5):e63886. Schriner SE, Lee K, Truong S, Salvadora KT, Maler S, Nam A, Lee T, Jafari M. PMID: 23704949; PMCID: PMC3660385.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    30. Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance. Longev Healthspan. 2013 04 02; 2(1):5. Gospodaryov DV, Yurkevych IS, Jafari M, Lushchak VI, Lushchak OV. PMID: 24472572; PMCID: PMC3922952.
      View in: PubMed   Mentions: 18  
    31. Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain. Bull Environ Contam Toxicol. 2012 Jul; 89(1):73-7. Nabavi SF, Habtemariam S, Jafari M, Sureda A, Nabavi SM. PMID: 22531840.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    32. Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster. Pharmacogenet Genomics. 2012 Apr; 22(4):285-9. Kislukhin G, Murphy ML, Jafari M, Long AD. PMID: 22336958; PMCID: PMC3303944.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    33. Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat. Biogerontology. 2012 Apr; 13(2):105-17. Schriner SE, Katoozi NS, Pham KQ, Gazarian M, Zarban A, Jafari M. PMID: 21928072; PMCID: PMC3288696.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    34. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 2012 Mar; 51(3):257-67. Liu Z, Li X, Simoneau AR, Jafari M, Zi X. PMID: 21520297; PMCID: PMC3144985.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    35. Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Res. 2010 Oct; 13(5):561-70. Lee KS, Lee BS, Semnani S, Avanesian A, Um CY, Jeon HJ, Seong KM, Yu K, Min KJ, Jafari M. PMID: 20645870.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    36. Drosophila melanogaster as a model system for the evaluation of anti-aging compounds. Fly (Austin). 2010 Jul-Sep; 4(3):253-7. Jafari M. PMID: 20473034.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    37. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. 2009 Sep; 43(9):836-43. Schriner SE, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, Holmbeck MA, Jafari M. PMID: 19634056.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    38. Can Drosophila melanogaster represent a model system for the detection of reproductive adverse drug reactions? Drug Discov Today. 2009 Aug; 14(15-16):761-6. Avanesian A, Semnani S, Jafari M. PMID: 19482095.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    39. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic Biol Med. 2009 Sep 01; 47(5):577-84. Schriner SE, Avanesian A, Liu Y, Luesch H, Jafari M. PMID: 19486939.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    40. Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology. 2010 Feb; 11(1):45-52. Avanesian A, Khodayari B, Felgner JS, Jafari M. PMID: 19430925; PMCID: PMC2797622.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    41. Rosa damascena decreased mortality in adult Drosophila. J Med Food. 2008 Mar; 11(1):9-13. Jafari M, Zarban A, Pham S, Wang T. PMID: 18361732.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    42. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation Res. 2007 Dec; 10(4):587-602. Jafari M, Felgner JS, Bussel II, Hutchili T, Khodayari B, Rose MR, Vince-Cruz C, Mueller LD. PMID: 17990971.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    43. Interactions between injury, stress resistance, reproduction, and aging in Drosophila melanogaster. Exp Gerontol. 2008 Mar; 43(3):136-45. Sepulveda S, Shojaeian P, Rauser CL, Jafari M, Mueller LD, Rose MR. PMID: 18053668; PMCID: PMC2703589.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    44. Pioglitazone: an anti-diabetic compound with anti-aging properties. Biogerontology. 2007 Dec; 8(6):639-51. Jafari M, Khodayari B, Felgner J, Bussel II, Rose MR, Mueller LD. PMID: 17628757.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    45. The pharmacology of ageing in Drosophila. Curr Drug Targets. 2006 Nov; 7(11):1479-83. Jafari M, Long AD, Mueller LD, Rose MR. PMID: 17100588.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    46. Rules for the use of model organisms in anti-aging pharmacology. Aging Cell. 2006 Feb; 5(1):17-22. Jafari M, Rose MR. PMID: 16441839.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    47. Efficacy of alternate-day dosing versus daily dosing of atorvastatin. J Cardiovasc Pharmacol Ther. 2003 Jun; 8(2):123-6. Jafari M, Ebrahimi R, Ahmadi-Kashani M, Balian H, Bashir M. PMID: 12808485.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    48. The effects of physical exercise on plasma prebeta-1 high-density lipoprotein. Metabolism. 2003 Apr; 52(4):437-42. Jafari M, Leaf DA, Macrae H, Kasem J, O'conner P, Pullinger C, Malloy M, Kane JP. PMID: 12701055.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    49. Dyslipidemia prevalence in a laboratory initiated screening program. Clin Lab Sci. 2002; 15(2):67-70. Emerson JF, Jafari M. PMID: 12776768.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
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