Mahtab Jafari

Title(s)Professor, Pharmaceutical Sciences
SchoolSchool of Pharmacy and Pharmaceutical Sciences
Address101 Theory, Suite 100
Irvine CA 92697-3958
Phone(949) 824-0145
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    Collapse Research 
    Collapse Research Activities and Funding
    Botanicals, Mitochondrial Bioenergetics, and Aging Pathways
    NIH R21AT004987Apr 1, 2010 - Mar 31, 2013
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Angelica keiskei Impacts the Lifespan and Healthspan of Drosophila melanogaster in a Sex and Strain-Dependent Manner. Pharmaceuticals (Basel). 2023 May 12; 16(5). Jafari M, Schriner SE, Kil YS, Pham ST, Seo EK. PMID: 37242522; PMCID: PMC10222730.
      View in: PubMed   Mentions:
    2. The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model. Sci Rep. 2022 06 22; 12(1):10581. Jafari M, Juanson Arabit JG, Courville R, Kiani D, Chaston JM, Nguyen CD, Jena N, Liu ZY, Tata P, Van Etten RA. PMID: 35732671; PMCID: PMC9217815.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    3. COVID-19, stress and mental health: What students expect from academic institutions during a pandemic. J Am Coll Health. 2021 Aug 16; 1-8. Jafari M, De Roche M, Eshaghi MR. PMID: 34398699.
      View in: PubMed   Mentions:    Fields:    
    4. Exosome loaded immunomodulatory biomaterials alleviate local immune response in immunocompetent diabetic mice post islet xenotransplantation. Commun Biol. 2021 06 03; 4(1):685. Mohammadi MR, Rodriguez SM, Luong JC, Li S, Cao R, Alshetaiwi H, Lau H, Davtyan H, Jones MB, Jafari M, Kessenbrock K, Villalta SA, de Vos P, Zhao W, Lakey JRT. PMID: 34083739; PMCID: PMC8175379.
      View in: PubMed   Mentions: 12  Translation:HumansAnimalsCells
    5. Diet and Botanical Supplementation: Combination Therapy for Healthspan Improvement? Rejuvenation Res. 2021 Oct; 24(5):331-344. Rutledge GA, Phang HJ, Le MN, Bui L, Rose MR, Mueller LD, Jafari M. PMID: 32924860.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. High-performance Countercurrent Chromatography to Access Rhodiola rosea Influenza Virus Inhibiting Constituents. Planta Med. 2021 Aug; 87(10-11):818-826. Langeder J, Grienke U, Döring K, Jafari M, Ehrhardt C, Schmidtke M, Rollinger JM. PMID: 32781473.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer's Disease. Biomed Res Int. 2018; 2018:3570830. Pham HM, Xu A, Schriner SE, Sevrioukov EA, Jafari M. PMID: 30228985; PMCID: PMC6136480.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    8. Rhodiola rosea Improves Lifespan, Locomotion, and Neurodegeneration in a Drosophila melanogaster Model of Huntington's Disease. Biomed Res Int. 2018; 2018:6726874. Arabit JGJ, Elhaj R, Schriner SE, Sevrioukov EA, Jafari M. PMID: 29984244; PMCID: PMC6015705.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    9. The impact of Rhodiola rosea on the gut microbial community of Drosophila melanogaster. Gut Pathog. 2018; 10:12. Labachyan KE, Kiani D, Sevrioukov EA, Schriner SE, Jafari M. PMID: 29581730; PMCID: PMC5861609.
      View in: PubMed   Mentions: 5  
    10. A unique degree program for pre-pharmacy education: An undergraduate degree in pharmaceutical sciences. Curr Pharm Teach Learn. 2018 02; 10(2):243-251. Jafari M. PMID: 29706283.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Minor phenolics from Angelica keiskei and their proliferative effects on Hep3B cells. Bioorg Med Chem Lett. 2017 07 15; 27(14):3065-3070. Kil YS, Park J, Jafari M, Woo HA, Seo EK. PMID: 28571822.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities. Arch Pharm Res. 2017 Jun; 40(6):655-675. Kil YS, Pham ST, Seo EK, Jafari M. PMID: 28439780; PMCID: PMC7090720.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    13. Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster. Arch Insect Biochem Physiol. 2016 Dec; 93(4):210-221. Lopez TE, Pham HM, Nguyen BV, Tahmasian Y, Ramsden S, Coskun V, Schriner SE, Jafari M. PMID: 27696504; PMCID: PMC5121014.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    14. Extension of Drosophila Lifespan by Rhodiola rosea Depends on Dietary Carbohydrate and Caloric Content in a Simplified Diet. J Med Food. 2016 Mar; 19(3):318-23. Schriner SE, Coskun V, Hogan SP, Nguyen CT, Lopez TE, Jafari M. PMID: 26987024.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    15. The impact of green tea polyphenols on development and reproduction in Drosophila melanogaster. J Funct Foods. 2016 Jan 01; 20:556-566. Lopez TE, Pham HM, Barbour J, Tran P, Van Nguyen B, Hogan SP, Homo RL, Coskun V, Schriner SE, Jafari M. PMID: 26693252; PMCID: PMC4683606.
      View in: PubMed   Mentions: 10  
    16. Healthspan Pharmacology. Rejuvenation Res. 2015 Dec; 18(6):573-80. Jafari M. PMID: 26444965; PMCID: PMC4685493.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    17. Chalcones from Angelica keiskei: Evaluation of Their Heat Shock Protein Inducing Activities. J Nat Prod. 2015 Oct 23; 78(10):2481-7. Kil YS, Choi SK, Lee YS, Jafari M, Seo EK. PMID: 26431394.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    18. Green tea polyphenols extend the lifespan of male drosophila melanogaster while impairing reproductive fitness. J Med Food. 2014 Dec; 17(12):1314-21. Lopez T, Schriner SE, Okoro M, Lu D, Chiang BT, Huey J, Jafari M. PMID: 25058464; PMCID: PMC4259189.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    19. Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico. Exp Gerontol. 2014 Dec; 60:220-30. Schriner SE, Kuramada S, Lopez TE, Truong S, Pham A, Jafari M. PMID: 25456850; PMCID: PMC4309393.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    20. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS One. 2013; 8(5):e63886. Schriner SE, Lee K, Truong S, Salvadora KT, Maler S, Nam A, Lee T, Jafari M. PMID: 23704949; PMCID: PMC3660385.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    21. Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance. Longev Healthspan. 2013 04 02; 2(1):5. Gospodaryov DV, Yurkevych IS, Jafari M, Lushchak VI, Lushchak OV. PMID: 24472572; PMCID: PMC3922952.
      View in: PubMed   Mentions: 16  
    22. Protective role of gallic acid on sodium fluoride induced oxidative stress in rat brain. Bull Environ Contam Toxicol. 2012 Jul; 89(1):73-7. Nabavi SF, Habtemariam S, Jafari M, Sureda A, Nabavi SM. PMID: 22531840.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    23. Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster. Pharmacogenet Genomics. 2012 Apr; 22(4):285-9. Kislukhin G, Murphy ML, Jafari M, Long AD. PMID: 22336958; PMCID: PMC3303944.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    24. Extension of Drosophila lifespan by Rosa damascena associated with an increased sensitivity to heat. Biogerontology. 2012 Apr; 13(2):105-17. Schriner SE, Katoozi NS, Pham KQ, Gazarian M, Zarban A, Jafari M. PMID: 21928072; PMCID: PMC3288696.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    25. Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Mol Carcinog. 2012 Mar; 51(3):257-67. Liu Z, Li X, Simoneau AR, Jafari M, Zi X. PMID: 21520297; PMCID: PMC3144985.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    26. Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster. Rejuvenation Res. 2010 Oct; 13(5):561-70. Lee KS, Lee BS, Semnani S, Avanesian A, Um CY, Jeon HJ, Seong KM, Yu K, Min KJ, Jafari M. PMID: 20645870.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    27. Drosophila melanogaster as a model system for the evaluation of anti-aging compounds. Fly (Austin). 2010 Jul-Sep; 4(3):253-7. Jafari M. PMID: 20473034.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    28. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. 2009 Sep; 43(9):836-43. Schriner SE, Abrahamyan A, Avanessian A, Bussel I, Maler S, Gazarian M, Holmbeck MA, Jafari M. PMID: 19634056.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. Can Drosophila melanogaster represent a model system for the detection of reproductive adverse drug reactions? Drug Discov Today. 2009 Aug; 14(15-16):761-6. Avanesian A, Semnani S, Jafari M. PMID: 19482095.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    30. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic Biol Med. 2009 Sep 01; 47(5):577-84. Schriner SE, Avanesian A, Liu Y, Luesch H, Jafari M. PMID: 19486939.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology. 2010 Feb; 11(1):45-52. Avanesian A, Khodayari B, Felgner JS, Jafari M. PMID: 19430925; PMCID: PMC2797622.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    32. Rosa damascena decreased mortality in adult Drosophila. J Med Food. 2008 Mar; 11(1):9-13. Jafari M, Zarban A, Pham S, Wang T. PMID: 18361732.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    33. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation Res. 2007 Dec; 10(4):587-602. Jafari M, Felgner JS, Bussel II, Hutchili T, Khodayari B, Rose MR, Vince-Cruz C, Mueller LD. PMID: 17990971.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    34. Interactions between injury, stress resistance, reproduction, and aging in Drosophila melanogaster. Exp Gerontol. 2008 Mar; 43(3):136-45. Sepulveda S, Shojaeian P, Rauser CL, Jafari M, Mueller LD, Rose MR. PMID: 18053668; PMCID: PMC2703589.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    35. Pioglitazone: an anti-diabetic compound with anti-aging properties. Biogerontology. 2007 Dec; 8(6):639-51. Jafari M, Khodayari B, Felgner J, Bussel II, Rose MR, Mueller LD. PMID: 17628757.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. The pharmacology of ageing in Drosophila. Curr Drug Targets. 2006 Nov; 7(11):1479-83. Jafari M, Long AD, Mueller LD, Rose MR. PMID: 17100588.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    37. Rules for the use of model organisms in anti-aging pharmacology. Aging Cell. 2006 Feb; 5(1):17-22. Jafari M, Rose MR. PMID: 16441839.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    38. Efficacy of alternate-day dosing versus daily dosing of atorvastatin. J Cardiovasc Pharmacol Ther. 2003 Jun; 8(2):123-6. Jafari M, Ebrahimi R, Ahmadi-Kashani M, Balian H, Bashir M. PMID: 12808485.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCTClinical Trials
    39. The effects of physical exercise on plasma prebeta-1 high-density lipoprotein. Metabolism. 2003 Apr; 52(4):437-42. Jafari M, Leaf DA, Macrae H, Kasem J, O'conner P, Pullinger C, Malloy M, Kane JP. PMID: 12701055.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    40. Dyslipidemia prevalence in a laboratory initiated screening program. Clin Lab Sci. 2002; 15(2):67-70. Emerson JF, Jafari M. PMID: 12776768.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
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