Pearlman, Eric

InstitutionUniversity of California, Irvine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1867
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    Collapse Research 
    Collapse Research Activities and Funding
    Innovative Therapeutic Targets for Fungal Keratitis
    NIH/NEI R21EY024817Sep 30, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Pathogenesis of Fungal Keratitis
    NIH/NEI R01EY018612Feb 1, 2008 - Jan 31, 2023
    Role: Principal Investigator
    Immunology Research Training Grant
    NIH/NIAID T32AI060573Jul 1, 2004 - Jul 31, 2021
    Role: Principal Investigator
    Toll Like Receptors in Bacterial Keratitis
    NIH/NEI R01EY014362Apr 1, 2003 - Dec 31, 2018
    Role: Principal Investigator
    Visual Sciences Training Program
    NIH/NEI T32EY007157Sep 30, 2000 - May 31, 2022
    Role: Principal Investigator
    P30 Core grant for Vision Research
    NIH/NEI P30EY011373Apr 1, 1997 - Aug 31, 2022
    Role: Co-Principal Investigator
    The Role of Wolbachia Endobacteria in River Blindness
    NIH/NEI R01EY010320Dec 1, 1993 - Nov 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Clark HL, Abbondante S, Minns MS, Greenberg EN, Sun Y, Pearlman E. Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and ß-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3. Front Immunol. 2018; 9:1182. PMID: 29896200.
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    2. Clark HL, Minns MS, Sun Y, de Jesus T, Ghannoum MG, Pearlman E. Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis. Invest Ophthalmol Vis Sci. 2018 Mar 01; 59(3):1589-1598. PMID: 29625485.
      View in: PubMed
    3. Minns MS, Pearlman E. Neutrophils Cause an Intravascular Traffic Jam. Cell Host Microbe. 2018 01 10; 23(1):6-8. PMID: 29324230.
      View in: PubMed
    4. Krokowski D, Guan BJ, Wu J, Zheng Y, Pattabiraman PP, Jobava R, Gao XH, Di XJ, Snider MD, Mu TW, Liu S, Storrie B, Pearlman E, Blumental-Perry A, Hatzoglou M. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017 Dec 05; 21(10):2895-2910. PMID: 29212034.
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    5. Vareechon C, Zmina SE, Karmakar M, Pearlman E, Rietsch A. Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils. Cell Host Microbe. 2017 May 10; 21(5):611-618.e5. PMID: 28494242.
      View in: PubMed
    6. Zhang X, Marchetti C, Lee J, Sun Y, Debanne S, Jiang Y, Kern J, Harrod M, Benetz BA, Pearlman E, Szczotka-Flynn L. The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy. Cont Lens Anterior Eye. 2017 Feb; 40(1):33-41. PMID: 27876528.
      View in: PubMed
    7. Mofidfar M, Wang J, Long L, Hager CL, Vareechon C, Pearlman E, Baer E, Ghannoum M, Wnek GE. Polymeric Nanofiber/Antifungal Formulations Using a Novel Co-extrusion Approach. AAPS PharmSciTech. 2017 Aug; 18(6):1917-1924. PMID: 27858252.
      View in: PubMed
    8. Taylor PR, Bonfield TL, Chmiel JF, Pearlman E. Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC. Clin Immunol. 2016 09; 170:53-60. PMID: 27155366.
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    9. Taylor PR, Roy S, Meszaros EC, Sun Y, Howell SJ, Malemud CJ, Pearlman E. JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity. J Leukoc Biol. 2016 07; 100(1):213-22. PMID: 27034404; PMCID: PMC4946614 [Available on 07/01/17].
    10. Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1ß secretion in response to ATP. Nat Commun. 2016 Feb 15; 7:10555. PMID: 26877061; PMCID: PMC4756306.
    11. Dietl AM, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, Pearlman E, Haas H. Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence. 2016 05 18; 7(4):465-76. PMID: 26854126.
      View in: PubMed
    12. Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E. Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection. J Immunol. 2016 Jan 01; 196(1):336-44. PMID: 26582948; PMCID: PMC4684987 [Available on 01/01/17].
    13. Taylor PR, Pearlman E. IL-17A production by neutrophils. Immunol Lett. 2016 Jan; 169:104-5. PMID: 26582721.
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    14. Lee JE, Sun Y, Gjorstrup P, Pearlman E. Inhibition of Corneal Inflammation by the Resolvin E1. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2728-36. PMID: 25758817; PMCID: PMC4416540.
    15. Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E. Neutrophil IL-1ß processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol. 2015 Feb 15; 194(4):1763-75. PMID: 25609842; PMCID: PMC4369676.
    16. Karthikeyan RS, Vareechon C, Prajna NV, Dharmalingam K, Pearlman E, Lalitha P. Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India. J Infect Dis. 2015 Jan 01; 211(1):130-4. PMID: 25001461; PMCID: PMC4402381.
    17. Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol. 2014 Apr 15; 192(8):3816-27. PMID: 24639355; PMCID: PMC4123815.
    18. Muszkieta L, Carrion Sde J, Robinet P, Beau R, Elbim C, Pearlman E, Latgé JP. The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence. Fungal Genet Biol. 2014 May; 66:79-85. PMID: 24614084; PMCID: PMC4503245.
    19. Taylor PR, Leal SM, Sun Y, Pearlman E. Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils. J Immunol. 2014 Apr 01; 192(7):3319-27. PMID: 24591369; PMCID: PMC4020181.
    20. Toska J, Sun Y, Carbonell DA, Foster AN, Jacobs MR, Pearlman E, Rietsch A. Diversity of virulence phenotypes among type III secretion negative Pseudomonas aeruginosa clinical isolates. PLoS One. 2014; 9(1):e86829. PMID: 24466261; PMCID: PMC3900666.
    21. Chandra J, Pearlman E, Ghannoum MA. Animal models to investigate fungal biofilm formation. Methods Mol Biol. 2014; 1147:141-57. PMID: 24664831.
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    22. Taylor PR, Roy S, Leal SM, Sun Y, Howell SJ, Cobb BA, Li X, Pearlman E. Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, ROR?t and dectin-2. Nat Immunol. 2014 Feb; 15(2):143-51. PMID: 24362892; PMCID: PMC3972892.
    23. Roy S, Karmakar M, Pearlman E. CD14 mediates Toll-like receptor 4 (TLR4) endocytosis and spleen tyrosine kinase (Syk) and interferon regulatory transcription factor 3 (IRF3) activation in epithelial cells and impairs neutrophil infiltration and Pseudomonas aeruginosa killing in vivo. J Biol Chem. 2014 Jan 10; 289(2):1174-82. PMID: 24275652; PMCID: PMC3887184.
    24. Carrion Sde J, Leal SM, Ghannoum MA, Aimanianda V, Latgé JP, Pearlman E. The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo. J Immunol. 2013 Sep 01; 191(5):2581-8. PMID: 23926321; PMCID: PMC4020118.
    25. Leal SM, Roy S, Vareechon C, Carrion Sd, Clark H, Lopez-Berges MS, Di Pietro A, diPietro A, Schrettl M, Beckmann N, Redl B, Haas H, Pearlman E. Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog. 2013; 9(7):e1003436. PMID: 23853581; PMCID: PMC3708856.
    26. Tang J, Allen Lee C, Du Y, Sun Y, Pearlman E, Sheibani N, Kern TS. MyD88-dependent pathways in leukocytes affect the retina in diabetes. PLoS One. 2013; 8(7):e68871. PMID: 23874797; PMCID: PMC3708907.
    27. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem. 2013 May 24; 288(21):15326-41. PMID: 23572532; PMCID: PMC3663552.
    28. Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A. Host defense at the ocular surface. Int Rev Immunol. 2013 Feb; 32(1):4-18. PMID: 23360155; PMCID: PMC3750950.
    29. Malemud CJ, Sun Y, Pearlman E, Ginley NM, Awadallah A, Wisler BA, Dennis JE. Monosodium Urate and Tumor Necrosis Factor-a Increase Apoptosis in Human Chondrocyte Cultures. Rheumatology (Sunnyvale). 2012 Dec 26; 2:113. PMID: 24660115.
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    30. Sun Y, Zhang R, Gadek TR, O'Neill CA, Pearlman E. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May; 29(4):395-402. PMID: 23215542; PMCID: PMC3643258.
    31. Zhou R, Zhang R, Sun Y, Platt S, Szczotka-Flynn L, Pearlman E. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25; 53(11):7382-8. PMID: 23033384; PMCID: PMC3481604.
    32. Karmakar M, Sun Y, Hise AG, Rietsch A, Pearlman E. Cutting edge: IL-1ß processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1. J Immunol. 2012 Nov 01; 189(9):4231-5. PMID: 23024281; PMCID: PMC3482477.
    33. Mukherjee PK, Chandra J, Yu C, Sun Y, Pearlman E, Ghannoum MA. Characterization of fusarium keratitis outbreak isolates: contribution of biofilms to antimicrobial resistance and pathogenesis. Invest Ophthalmol Vis Sci. 2012 Jul 03; 53(8):4450-7. PMID: 22669723; PMCID: PMC3394686.
    34. Leal SM, Vareechon C, Cowden S, Cobb BA, Latgé JP, Momany M, Pearlman E. Fungal antioxidant pathways promote survival against neutrophils during infection. J Clin Invest. 2012 Jul; 122(7):2482-98. PMID: 22706306; PMCID: PMC3534057.
    35. Leal SM, Pearlman E. The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models. Cytokine. 2012 Apr; 58(1):107-11. PMID: 22280957; PMCID: PMC3290702.
    36. Sun Y, Karmakar M, Taylor PR, Rietsch A, Pearlman E. ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival. J Immunol. 2012 Feb 15; 188(4):1884-95. PMID: 22250085; PMCID: PMC3273577.
    37. Chinnery HR, McLenachan S, Binz N, Sun Y, Forrester JV, Degli-Esposti MA, Pearlman E, McMenamin PG. TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation. Am J Pathol. 2012 Jan; 180(1):209-20. PMID: 22085974; PMCID: PMC3338340.
    38. Karthikeyan RS, Leal SM, Prajna NV, Dharmalingam K, Geiser DM, Pearlman E, Lalitha P. Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium. J Infect Dis. 2011 Sep 15; 204(6):942-50. PMID: 21828275; PMCID: PMC3156922.
    39. Roy S, Sun Y, Pearlman E. Interferon-gamma-induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter. J Biol Chem. 2011 Jul 08; 286(27):23753-62. PMID: 21572044; PMCID: PMC3129156.
    40. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29; 286(17):15543-55. PMID: 21383019; PMCID: PMC3083179.
    41. Tu Z, Portillo JA, Howell S, Bu H, Subauste CS, Al-Ubaidi MR, Pearlman E, Lin F. Photoreceptor cells constitutively express functional TLR4. J Neuroimmunol. 2011 Jan; 230(1-2):183-7. PMID: 20801528; PMCID: PMC3019248.
    42. Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E. TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways. J Immunol. 2010 Oct 01; 185(7):4272-83. PMID: 20826748; PMCID: PMC3392180.
    43. Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW. Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci. 2010 Sep 01; 123(Pt 17):2987-95. PMID: 20699360; PMCID: PMC2923572.
    44. Leal SM, Cowden S, Hsia YC, Ghannoum MA, Momany M, Pearlman E. Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. PLoS Pathog. 2010 Jul 01; 6:e1000976. PMID: 20617171; PMCID: PMC2895653.
    45. Carlson EC, Sun Y, Auletta J, Kao WW, Liu CY, Perez VL, Pearlman E. Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. J Leukoc Biol. 2010 Sep; 88(3):517-22. PMID: 20495072; PMCID: PMC2924604.
    46. Szczotka-Flynn LB, Pearlman E, Ghannoum M. Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review. Eye Contact Lens. 2010 Mar; 36(2):116-29. PMID: 20168237; PMCID: PMC3482476.
    47. Sun Y, Chandra J, Mukherjee P, Szczotka-Flynn L, Ghannoum MA, Pearlman E. A murine model of contact lens-associated fusarium keratitis. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1511-6. PMID: 19875664; PMCID: PMC2868423.
    48. Szczotka-Flynn LB, Imamura Y, Chandra J, Yu C, Mukherjee PK, Pearlman E, Ghannoum MA. Increased resistance of contact lens-related bacterial biofilms to antimicrobial activity of soft contact lens care solutions. Cornea. 2009 Sep; 28(8):918-26. PMID: 19654521; PMCID: PMC4020144.
    49. Chinnery HR, Carlson EC, Sun Y, Lin M, Burnett SH, Perez VL, McMenamin PG, Pearlman E. Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. J Immunol. 2009 Mar 01; 182(5):2738-44. PMID: 19234168; PMCID: PMC3909485.
    50. Gentil K, Pearlman E. Gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis. Infect Immun. 2009 Apr; 77(4):1606-12. PMID: 19168746; PMCID: PMC2663151.
    51. Sun Y, Pearlman E. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1247-54. PMID: 18936141; PMCID: PMC3909488.
    52. Pearlman E, Johnson A, Adhikary G, Sun Y, Chinnery HR, Fox T, Kester M, McMenamin PG. Toll-like receptors at the ocular surface. Ocul Surf. 2008 Jul; 6(3):108-16. PMID: 18781257.
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    53. Tarabishy AB, Aldabagh B, Sun Y, Imamura Y, Mukherjee PK, Lass JH, Ghannoum MA, Pearlman E. MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2. J Immunol. 2008 Jul 01; 181(1):593-600. PMID: 18566426; PMCID: PMC3909484.
    54. Lin M, Jackson P, Tester AM, Diaconu E, Overall CM, Blalock JE, Pearlman E. Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am J Pathol. 2008 Jul; 173(1):144-53. PMID: 18556780; PMCID: PMC2438292.
    55. Sun Y, Fox T, Adhikary G, Kester M, Pearlman E. Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J Leukoc Biol. 2008 Jun; 83(6):1512-21. PMID: 18372342; PMCID: PMC3584160.
    56. Adhikary G, Sun Y, Pearlman E. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. J Leukoc Biol. 2008 Apr; 83(4):991-7. PMID: 18218857; PMCID: PMC3959745.
    57. Johnson AC, Li X, Pearlman E. MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase. J Biol Chem. 2008 Feb 15; 283(7):3988-96. PMID: 18057004.
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    58. Imamura Y, Chandra J, Mukherjee PK, Lattif AA, Szczotka-Flynn LB, Pearlman E, Lass JH, O'Donnell K, Ghannoum MA. Fusarium and Candida albicans biofilms on soft contact lenses: model development, influence of lens type, and susceptibility to lens care solutions. Antimicrob Agents Chemother. 2008 Jan; 52(1):171-82. PMID: 17999966; PMCID: PMC2223913.
    59. Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E. Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. J Biol Chem. 2007 Dec 07; 282(49):35502-9. PMID: 17911102; PMCID: PMC3909483.
    60. Gillette-Ferguson I, Daehnel K, Hise AG, Sun Y, Carlson E, Diaconu E, McGarry HF, Taylor MJ, Pearlman E. Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis. Infect Immun. 2007 Dec; 75(12):5908-15. PMID: 17875630; PMCID: PMC2168349.
    61. Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E. Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. J Immunol. 2007 Jan 15; 178(2):1068-76. PMID: 17202370.
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    62. Pearlman E, Gillette-Ferguson I. Onchocerca volvulus, Wolbachia and river blindness. Chem Immunol Allergy. 2007; 92:254-65. PMID: 17264501.
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    63. Lin M, Carlson E, Diaconu E, Pearlman E. CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis. J Leukoc Biol. 2007 Mar; 81(3):786-92. PMID: 17110418; PMCID: PMC3909486.
    64. Sun Y, Hise AG, Kalsow CM, Pearlman E. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Infect Immun. 2006 Sep; 74(9):5325-32. PMID: 16926427; PMCID: PMC1594867.
    65. Gillette-Ferguson I, Hise AG, Sun Y, Diaconu E, McGarry HF, Taylor MJ, Pearlman E. Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88. Infect Immun. 2006 Apr; 74(4):2442-5. PMID: 16552075; PMCID: PMC1418907.
    66. Johnson A, Pearlman E. Toll-like receptors in the cornea. Ocul Surf. 2005 Oct; 3(4 Suppl):S187-9. PMID: 17216116.
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    67. Johnson AC, Heinzel FP, Diaconu E, Sun Y, Hise AG, Golenbock D, Lass JH, Pearlman E. Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Invest Ophthalmol Vis Sci. 2005 Feb; 46(2):589-95. PMID: 15671286.
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    68. Gillette-Ferguson I, Hise AG, McGarry HF, Turner J, Esposito A, Sun Y, Diaconu E, Taylor MJ, Pearlman E. Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness). Infect Immun. 2004 Oct; 72(10):5687-92. PMID: 15385467; PMCID: PMC517527.
    69. Pearlman E. Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria. Med Microbiol Immunol. 2003 Feb; 192(1):57-60. PMID: 12592565.
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    70. Hise AG, Gillette-Ferguson I, Pearlman E. Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria. J Endotoxin Res. 2003; 9(6):390-4. PMID: 14733727.
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    71. Berger RB, Blackwell NM, Lass JH, Diaconu E, Pearlman E. IL-4 and IL-13 regulation of ICAM-1 expression and eosinophil recruitment in Onchocerca volvulus keratitis. Invest Ophthalmol Vis Sci. 2002 Sep; 43(9):2992-7. PMID: 12202520.
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    72. Khatri S, Lass JH, Heinzel FP, Petroll WM, Gomez J, Diaconu E, Kalsow CM, Pearlman E. Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4. Invest Ophthalmol Vis Sci. 2002 Jul; 43(7):2278-84. PMID: 12091428.
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    73. Saint André Av, Blackwell NM, Hall LR, Hoerauf A, Brattig NW, Volkmann L, Taylor MJ, Ford L, Hise AG, Lass JH, Diaconu E, Pearlman E. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science. 2002 Mar 08; 295(5561):1892-5. PMID: 11884755.
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    74. Hall LR, Berger RB, Diaconu E, Pearlman E. Onchocerca volvulus keratitis (river blindness) is exacerbated in BALB/c IL-4 gene knockout mice. Cell Immunol. 2002 Mar-Apr; 216(1-2):1-5. PMID: 12381344.
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