Eric Pearlman

Title(s)Professor, Ophthalmology
SchoolSchool of Medicine
Address1001 Health Sciences Road
Irvine CA 92697-3950
Phone(949) 824-1867
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    Collapse Research 
    Collapse Research Activities and Funding
    The role of Gasdermin E (DFNA5) in bacterial keratitis
    NIH R21EY032662May 1, 2021 - Apr 30, 2023
    Role: Principal Investigator
    Epigenetic changes to the IL-17 promoter landscape in neutrophils
    NIH R21AI149239Jun 15, 2020 - May 31, 2022
    Role: Principal Investigator
    Innovative Therapeutic Targets for Fungal Keratitis
    NIH R21EY024817Sep 30, 2014 - Aug 31, 2018
    Role: Principal Investigator
    Pathogenesis of Fungal Keratitis
    NIH R01EY018612Feb 1, 2008 - Jan 31, 2023
    Role: Principal Investigator
    Immunology Research Training Grant
    NIH T32AI060573Jul 1, 2004 - Jul 31, 2021
    Role: Principal Investigator
    Innate immunity in bacterial keratitis
    NIH R01EY014362Apr 1, 2003 - Jun 30, 2023
    Role: Principal Investigator
    Visual Sciences Training Program
    NIH T32EY007157Sep 30, 2000 - May 31, 2022
    Role: Principal Investigator
    P30 Core grant for Vision Research
    NIH P30EY011373Apr 1, 1997 - Aug 31, 2022
    Role: Co-Principal Investigator
    The Role of Wolbachia Endobacteria in River Blindness
    NIH R01EY010320Dec 1, 1993 - Nov 30, 2008
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NLRP3 selectively drives IL-1β secretion by Pseudomonas aeruginosa infected neutrophils and regulates corneal disease severity. Nat Commun. 2023 09 20; 14(1):5832. Minns MS, Liboro K, Lima TS, Abbondante S, Miller BA, Marshall ME, Tran Chau J, Roistacher A, Rietsch A, Dubyak GR, Pearlman E. PMID: 37730693; PMCID: PMC10511713.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Immunity to pathogenic fungi in the eye. Semin Immunol. 2023 05; 67:101753. Abbondante S, Leal SM, Clark HL, Ratitong B, Sun Y, Ma LJ, Pearlman E. PMID: 37060806; PMCID: PMC10508057.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice. Diabetologia. 2023 03; 66(3):590-602. Saadane A, Veenstra AA, Minns MS, Tang J, Du Y, Abubakr Elghazali F, Lessieur EM, Pearlman E, Kern TS. PMID: 36698021; PMCID: PMC9892100.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Pyroptosis in neutrophils: Multimodal integration of inflammasome and regulated cell death signaling pathways. Immunol Rev. 2023 03; 314(1):229-249. Dubyak GR, Miller BA, Pearlman E. PMID: 36656082; PMCID: PMC10407921.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. Differential Roles for IL-1α and IL-1β in Pseudomonas aeruginosa Corneal Infection. J Immunol. 2022 Aug 01; 209(3):548-558. Ratitong B, Marshall ME, Dragan MA, Anunciado CM, Abbondante S, Pearlman E. PMID: 35851538; PMCID: PMC9922050.
      View in: PubMed   Mentions: 3     Fields:    
    6. Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence. PLoS Pathog. 2022 01; 18(1):e1010192. Yang M, Solis NV, Marshall M, Garleb R, Zhou T, Wang D, Swidergall M, Pearlman E, Filler SG, Liu H. PMID: 34995333; PMCID: PMC8775328.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    7. Pathogenic Aspergillus and Fusarium as important causes of blinding corneal infections - the role of neutrophils in fungal killing, tissue damage and cytokine production. Curr Opin Microbiol. 2021 10; 63:195-203. Ratitong B, Pearlman E. PMID: 34419783; PMCID: PMC10492570.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles. Cell Rep. 2021 05 18; 35(7):109139. Ratitong B, Marshall M, Pearlman E. PMID: 34010648; PMCID: PMC8186457.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. The impact of age-related hypomethylated DNA on immune signaling upon cellular demise. Trends Immunol. 2021 06; 42(6):464-468. Urban LA, Trinh A, Pearlman E, Siryaporn A, Downing TL. PMID: 33994111; PMCID: PMC9650629.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    10. OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia. J Invest Dermatol. 2021 06; 141(6):1542-1552. Sun P, Vu R, Dragan M, Haensel D, Gutierrez G, Nguyen Q, Greenberg E, Chen Z, Wu J, Atwood S, Pearlman E, Shi Y, Han W, Kessenbrock K, Dai X. PMID: 33333123; PMCID: PMC8532526.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    11. Synergistic Antimicrobial Activity of a Nanopillar Surface on a Chitosan Hydrogel. ACS Appl Bio Mater. 2020 Nov 16; 3(11):8040-8048. Heedy S, Marshall ME, Pineda JJ, Pearlman E, Yee AF. PMID: 35019543.
      View in: PubMed   Mentions:    Fields:    
    12. N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis. Nat Commun. 2020 05 05; 11(1):2212. Karmakar M, Minns M, Greenberg EN, Diaz-Aponte J, Pestonjamasp K, Johnson JL, Rathkey JK, Abbott DW, Wang K, Shao F, Catz SD, Dubyak GR, Pearlman E. PMID: 32371889; PMCID: PMC7200749.
      View in: PubMed   Mentions: 142     Fields:    Translation:HumansAnimalsCells
    13. What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus? Front Cell Infect Microbiol. 2020; 10:28. Mouyna I, Dellière S, Beauvais A, Gravelat F, Snarr B, Lehoux M, Zacharias C, Sun Y, de Jesus Carrion S, Pearlman E, Sheppard DC, Latgé JP. PMID: 32117802; PMCID: PMC7016196.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    14. The genome of opportunistic fungal pathogen Fusarium oxysporum carries a unique set of lineage-specific chromosomes. Commun Biol. 2020 01 31; 3(1):50. Zhang Y, Yang H, Turra D, Zhou S, Ayhan DH, DeIulio GA, Guo L, Broz K, Wiederhold N, Coleman JJ, Donnell KO, Youngster I, McAdam AJ, Savinov S, Shea T, Young S, Zeng Q, Rep M, Pearlman E, Schwartz DC, Di Pietro A, Kistler HC, Ma LJ. PMID: 32005944; PMCID: PMC6994591.
      View in: PubMed   Mentions: 27  Translation:HumansAnimalsCells
    15. Tuning Subunit Vaccines with Novel TLR Triagonist Adjuvants to Generate Protective Immune Responses against Coxiella burnetii. J Immunol. 2020 02 01; 204(3):611-621. Gilkes AP, Albin TJ, Manna S, Supnet M, Ruiz S, Tom J, Badten AJ, Jain A, Nakajima R, Felgner J, Davies DH, Stetkevich SA, Zlotnik A, Pearlman E, Nalca A, Felgner PL, Esser-Kahn AP, Burkhardt AM. PMID: 31871024.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    16. Delineating the role of MITF isoforms in pigmentation and tissue homeostasis. Pigment Cell Melanoma Res. 2020 03; 33(2):279-292. Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J, Ganesan AK. PMID: 31562697; PMCID: PMC7822220.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease. Front Immunol. 2019; 10:1631. Coulon PG, Dhanushkodi N, Prakash S, Srivastava R, Roy S, Alomari NI, Nguyen AM, Warsi WR, Ye C, Carlos-Cruz EA, Mai UT, Cruel AC, Ekmekciyan KM, Pearlman E, BenMohamed L. PMID: 31367214; PMCID: PMC6644090.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    18. EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection. Cell Rep. 2019 07 09; 28(2):423-433.e5. Swidergall M, Solis NV, Wang Z, Phan QT, Marshall ME, Lionakis MS, Pearlman E, Filler SG. PMID: 31291578; PMCID: PMC6638578.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    19. Biomimetic Nanopillared Surfaces Inhibit Drug Resistant Filamentous Fungal Growth. ACS Appl Bio Mater. 2019 Aug 19; 2(8):3159-3163. Rosenzweig R, Marshall M, Parivar A, Ly VK, Pearlman E, Yee AF. PMID: 35030760.
      View in: PubMed   Mentions: 2     Fields:    
    20. Linked Toll-Like Receptor Triagonists Stimulate Distinct, Combination-Dependent Innate Immune Responses. ACS Cent Sci. 2019 Jul 24; 5(7):1137-1145. Albin TJ, Tom JK, Manna S, Gilkes AP, Stetkevich SA, Katz BB, Supnet M, Felgner J, Jain A, Nakajima R, Jasinskas A, Zlotnik A, Pearlman E, Davies DH, Felgner PL, Burkhardt AM, Esser-Kahn AP. PMID: 31403067; PMCID: PMC6661867.
      View in: PubMed   Mentions: 16  
    21. Breaching bacterial biofilm with neutrophil α-mannosidase. J Leukoc Biol. 2019 06; 105(6):1085. Abbondante S, Pearlman E. PMID: 31116437.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase. Eur J Immunol. 2019 06; 49(6):918-927. de Jesus Carrion S, Abbondante S, Clark HL, Marshall ME, Mouyna I, Beauvais A, Sun Y, Taylor PR, Leal SM, Armstrong B, Carrera W, Latge JP, Pearlman E. PMID: 30903663; PMCID: PMC6999821.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Sustained release of decorin to the surface of the eye enables scarless corneal regeneration. NPJ Regen Med. 2018; 3:23. Hill LJ, Moakes RJA, Vareechon C, Butt G, Ng A, Brock K, Chouhan G, Vincent RC, Abbondante S, Williams RL, Barnes NM, Pearlman E, Wallace GR, Rauz S, Logan A, Grover LM. PMID: 30588331; PMCID: PMC6303295.
      View in: PubMed   Mentions: 16  
    24. Neutrophil Caspase-11 Is Required for Cleavage of Caspase-1 and Secretion of IL-1β in Aspergillus fumigatus Infection. J Immunol. 2018 11 01; 201(9):2767-2775. Sun Y, Abbondante S, Karmakar M, de Jesus Carrion S, Che C, Hise AG, Pearlman E. PMID: 30266768; PMCID: PMC6200591.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    25. Protein Deiminase 4 and CR3 Regulate Aspergillus fumigatus and β-Glucan-Induced Neutrophil Extracellular Trap Formation, but Hyphal Killing Is Dependent Only on CR3. Front Immunol. 2018; 9:1182. Clark HL, Abbondante S, Minns MS, Greenberg EN, Sun Y, Pearlman E. PMID: 29896200; PMCID: PMC5986955.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    26. Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis. Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1589-1598. Clark HL, Minns MS, Sun Y, de Jesus T, Ghannoum MG, Pearlman E. PMID: 29625485; PMCID: PMC5863689.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. Neutrophils Cause an Intravascular Traffic Jam. Cell Host Microbe. 2018 01 10; 23(1):6-8. Minns MS, Pearlman E. PMID: 29324230.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    28. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017 Dec 05; 21(10):2895-2910. Krokowski D, Guan BJ, Wu J, Zheng Y, Pattabiraman PP, Jobava R, Gao XH, Di XJ, Snider MD, Mu TW, Liu S, Storrie B, Pearlman E, Blumental-Perry A, Hatzoglou M. PMID: 29212034; PMCID: PMC5720379.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    29. Pseudomonas aeruginosa Effector ExoS Inhibits ROS Production in Human Neutrophils. Cell Host Microbe. 2017 May 10; 21(5):611-618.e5. Vareechon C, Zmina SE, Karmakar M, Pearlman E, Rietsch A. PMID: 28494242; PMCID: PMC5478421.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    30. The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy. Cont Lens Anterior Eye. 2017 Feb; 40(1):33-41. Zhang X, Marchetti C, Lee J, Sun Y, Debanne S, Jiang Y, Kern J, Harrod M, Benetz BA, Pearlman E, Szczotka-Flynn L. PMID: 27876528.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    31. Polymeric Nanofiber/Antifungal Formulations Using a Novel Co-extrusion Approach. AAPS PharmSciTech. 2017 Aug; 18(6):1917-1924. Mofidfar M, Wang J, Long L, Hager CL, Vareechon C, Pearlman E, Baer E, Ghannoum M, Wnek GE. PMID: 27858252.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    32. Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC. Clin Immunol. 2016 09; 170:53-60. Taylor PR, Bonfield TL, Chmiel JF, Pearlman E. PMID: 27155366.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    33. JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity. J Leukoc Biol. 2016 07; 100(1):213-22. Taylor PR, Roy S, Meszaros EC, Sun Y, Howell SJ, Malemud CJ, Pearlman E. PMID: 27034404; PMCID: PMC4946614.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    34. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat Commun. 2016 Feb 15; 7:10555. Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E. PMID: 26877061; PMCID: PMC4756306.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    35. Histidine biosynthesis plays a crucial role in metal homeostasis and virulence of Aspergillus fumigatus. Virulence. 2016 05 18; 7(4):465-76. Dietl AM, Amich J, Leal S, Beckmann N, Binder U, Beilhack A, Pearlman E, Haas H. PMID: 26854126; PMCID: PMC4871644.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    36. Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection. J Immunol. 2016 Jan 01; 196(1):336-44. Clark HL, Jhingran A, Sun Y, Vareechon C, de Jesus Carrion S, Skaar EP, Chazin WJ, Calera JA, Hohl TM, Pearlman E. PMID: 26582948; PMCID: PMC4684987.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    37. Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street. Immunity. 2015 Nov 17; 43(5):845-58. Underhill DM, Pearlman E. PMID: 26588778; PMCID: PMC4865256.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    38. IL-17A production by neutrophils. Immunol Lett. 2016 Jan; 169:104-5. Taylor PR, Pearlman E. PMID: 26582721.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    39. Inhibition of Corneal Inflammation by the Resolvin E1. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2728-36. Lee JE, Sun Y, Gjorstrup P, Pearlman E. PMID: 25758817; PMCID: PMC4416540.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    40. Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol. 2015 Feb 15; 194(4):1763-75. Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E. PMID: 25609842; PMCID: PMC4369676.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansAnimalsCells
    41. Interleukin 17 expression in peripheral blood neutrophils from fungal keratitis patients and healthy cohorts in southern India. J Infect Dis. 2015 Jan 01; 211(1):130-4. Karthikeyan RS, Vareechon C, Prajna NV, Dharmalingam K, Pearlman E, Lalitha P. PMID: 25001461; PMCID: PMC4402381.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    42. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J Immunol. 2014 Apr 15; 192(8):3816-27. Kohno H, Maeda T, Perusek L, Pearlman E, Maeda A. PMID: 24639355; PMCID: PMC4123815.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    43. The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence. Fungal Genet Biol. 2014 May; 66:79-85. Muszkieta L, Carrion Sde J, Robinet P, Beau R, Elbim C, Pearlman E, Latgé JP. PMID: 24614084; PMCID: PMC4503245.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    44. Aspergillus and Fusarium corneal infections are regulated by Th17 cells and IL-17-producing neutrophils. J Immunol. 2014 Apr 01; 192(7):3319-27. Taylor PR, Leal SM, Sun Y, Pearlman E. PMID: 24591369; PMCID: PMC4020181.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    45. Diversity of virulence phenotypes among type III secretion negative Pseudomonas aeruginosa clinical isolates. PLoS One. 2014; 9(1):e86829. Toska J, Sun Y, Carbonell DA, Foster AN, Jacobs MR, Pearlman E, Rietsch A. PMID: 24466261; PMCID: PMC3900666.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    46. Animal models to investigate fungal biofilm formation. Methods Mol Biol. 2014; 1147:141-57. Chandra J, Pearlman E, Ghannoum MA. PMID: 24664831.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    47. Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2. Nat Immunol. 2014 Feb; 15(2):143-51. Taylor PR, Roy S, Leal SM, Sun Y, Howell SJ, Cobb BA, Li X, Pearlman E. PMID: 24362892; PMCID: PMC3972892.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    48. Mgat2 ablation in the myeloid lineage leads to defective glycoantigen T cell responses. Glycobiology. 2014 Mar; 24(3):262-71. Ryan SO, Leal SM, Abbott DW, Pearlman E, Cobb BA. PMID: 24310166; PMCID: PMC3919469.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    49. CD14 mediates Toll-like receptor 4 (TLR4) endocytosis and spleen tyrosine kinase (Syk) and interferon regulatory transcription factor 3 (IRF3) activation in epithelial cells and impairs neutrophil infiltration and Pseudomonas aeruginosa killing in vivo. J Biol Chem. 2014 Jan 10; 289(2):1174-82. Roy S, Karmakar M, Pearlman E. PMID: 24275652; PMCID: PMC3887184.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    50. The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo. J Immunol. 2013 Sep 01; 191(5):2581-8. Carrion Sde J, Leal SM, Ghannoum MA, Aimanianda V, Latgé JP, Pearlman E. PMID: 23926321; PMCID: PMC4020118.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    51. MyD88-dependent pathways in leukocytes affect the retina in diabetes. PLoS One. 2013; 8(7):e68871. Tang J, Allen Lee C, Du Y, Sun Y, Pearlman E, Sheibani N, Kern TS. PMID: 23874797; PMCID: PMC3708907.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    52. Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog. 2013; 9(7):e1003436. Leal SM, Roy S, Vareechon C, Carrion Sd, Clark H, Lopez-Berges MS, Di Pietro A, diPietro A, Schrettl M, Beckmann N, Redl B, Haas H, Pearlman E. PMID: 23853581; PMCID: PMC3708856.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    53. Host response and bacterial virulence factor expression in Pseudomonas aeruginosa and Streptococcus pneumoniae corneal ulcers. PLoS One. 2013; 8(6):e64867. Karthikeyan RS, Priya JL, Leal SM, Toska J, Rietsch A, Prajna V, Pearlman E, Lalitha P. PMID: 23750216; PMCID: PMC3672173.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    54. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem. 2013 May 24; 288(21):15326-41. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. PMID: 23572532; PMCID: PMC3663552.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    55. Host defense at the ocular surface. Int Rev Immunol. 2013 Feb; 32(1):4-18. Pearlman E, Sun Y, Roy S, Karmakar M, Hise AG, Szczotka-Flynn L, Ghannoum M, Chinnery HR, McMenamin PG, Rietsch A. PMID: 23360155; PMCID: PMC3750950.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    56. Monosodium Urate and Tumor Necrosis Factor-α Increase Apoptosis in Human Chondrocyte Cultures. Rheumatology (Sunnyvale). 2012 Dec 26; 2:113. Malemud CJ, Sun Y, Pearlman E, Ginley NM, Awadallah A, Wisler BA, Dennis JE. PMID: 24660115; PMCID: PMC3959644.
      View in: PubMed   Mentions: 15  
    57. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118). J Ocul Pharmacol Ther. 2013 May; 29(4):395-402. Sun Y, Zhang R, Gadek TR, O'Neill CA, Pearlman E. PMID: 23215542; PMCID: PMC3643258.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    58. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25; 53(11):7382-8. Zhou R, Zhang R, Sun Y, Platt S, Szczotka-Flynn L, Pearlman E. PMID: 23033384; PMCID: PMC3481604.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    59. Cutting edge: IL-1β processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1. J Immunol. 2012 Nov 01; 189(9):4231-5. Karmakar M, Sun Y, Hise AG, Rietsch A, Pearlman E. PMID: 23024281; PMCID: PMC3482477.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    60. Characterization of fusarium keratitis outbreak isolates: contribution of biofilms to antimicrobial resistance and pathogenesis. Invest Ophthalmol Vis Sci. 2012 Jul 03; 53(8):4450-7. Mukherjee PK, Chandra J, Yu C, Sun Y, Pearlman E, Ghannoum MA. PMID: 22669723; PMCID: PMC3394686.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsPHPublic Health
    61. Fungal antioxidant pathways promote survival against neutrophils during infection. J Clin Invest. 2012 Jul; 122(7):2482-98. Leal SM, Vareechon C, Cowden S, Cobb BA, Latgé JP, Momany M, Pearlman E. PMID: 22706306; PMCID: PMC3534057.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    62. The role of cytokines and pathogen recognition molecules in fungal keratitis - Insights from human disease and animal models. Cytokine. 2012 Apr; 58(1):107-11. Leal SM, Pearlman E. PMID: 22280957; PMCID: PMC3290702.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    63. ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival. J Immunol. 2012 Feb 15; 188(4):1884-95. Sun Y, Karmakar M, Taylor PR, Rietsch A, Pearlman E. PMID: 22250085; PMCID: PMC3273577.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    64. TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation. Am J Pathol. 2012 Jan; 180(1):209-20. Chinnery HR, McLenachan S, Binz N, Sun Y, Forrester JV, Degli-Esposti MA, Pearlman E, McMenamin PG. PMID: 22085974; PMCID: PMC3338340.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    65. Expression of innate and adaptive immune mediators in human corneal tissue infected with Aspergillus or fusarium. J Infect Dis. 2011 Sep 15; 204(6):942-50. Karthikeyan RS, Leal SM, Prajna NV, Dharmalingam K, Geiser DM, Pearlman E, Lalitha P. PMID: 21828275; PMCID: PMC3156922.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    66. Interferon-gamma-induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter. J Biol Chem. 2011 Jul 08; 286(27):23753-62. Roy S, Sun Y, Pearlman E. PMID: 21572044; PMCID: PMC3129156.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    67. Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29; 286(17):15543-55. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. PMID: 21383019; PMCID: PMC3083179.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    68. Photoreceptor cells constitutively express functional TLR4. J Neuroimmunol. 2011 Jan; 230(1-2):183-7. Tu Z, Portillo JA, Howell S, Bu H, Subauste CS, Al-Ubaidi MR, Pearlman E, Lin F. PMID: 20801528; PMCID: PMC3019248.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    69. TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and -independent pathways. J Immunol. 2010 Oct 01; 185(7):4272-83. Sun Y, Karmakar M, Roy S, Ramadan RT, Williams SR, Howell S, Shive CL, Han Y, Stopford CM, Rietsch A, Pearlman E. PMID: 20826748; PMCID: PMC3392180.
      View in: PubMed   Mentions: 88     Fields:    Translation:AnimalsCells
    70. Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci. 2010 Sep 01; 123(Pt 17):2987-95. Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW. PMID: 20699360; PMCID: PMC2923572.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    71. Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis. PLoS Pathog. 2010 Jul 01; 6:e1000976. Leal SM, Cowden S, Hsia YC, Ghannoum MA, Momany M, Pearlman E. PMID: 20617171; PMCID: PMC2895653.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    72. Regulation of corneal inflammation by neutrophil-dependent cleavage of keratan sulfate proteoglycans as a model for breakdown of the chemokine gradient. J Leukoc Biol. 2010 Sep; 88(3):517-22. Carlson EC, Sun Y, Auletta J, Kao WW, Liu CY, Perez VL, Pearlman E. PMID: 20495072; PMCID: PMC2924604.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    73. Microbial contamination of contact lenses, lens care solutions, and their accessories: a literature review. Eye Contact Lens. 2010 Mar; 36(2):116-29. Szczotka-Flynn LB, Pearlman E, Ghannoum M. PMID: 20168237; PMCID: PMC3482476.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansCellsPHPublic Health
    74. A murine model of contact lens-associated fusarium keratitis. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1511-6. Sun Y, Chandra J, Mukherjee P, Szczotka-Flynn L, Ghannoum MA, Pearlman E. PMID: 19875664; PMCID: PMC2868423.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    75. Increased resistance of contact lens-related bacterial biofilms to antimicrobial activity of soft contact lens care solutions. Cornea. 2009 Sep; 28(8):918-26. Szczotka-Flynn LB, Imamura Y, Chandra J, Yu C, Mukherjee PK, Pearlman E, Ghannoum MA. PMID: 19654521; PMCID: PMC4020144.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    76. Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis. J Biol Chem. 2009 Aug 14; 284(33):22364-22378. Turner JD, Langley RS, Johnston KL, Gentil K, Ford L, Wu B, Graham M, Sharpley F, Slatko B, Pearlman E, Taylor MJ. PMID: 19458089; PMCID: PMC2755959.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    77. Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. J Immunol. 2009 Mar 01; 182(5):2738-44. Chinnery HR, Carlson EC, Sun Y, Lin M, Burnett SH, Perez VL, McMenamin PG, Pearlman E. PMID: 19234168; PMCID: PMC3909485.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    78. Gamma interferon and interleukin-1 receptor 1 regulate neutrophil recruitment to the corneal stroma in a murine model of Onchocerca volvulus keratitis. Infect Immun. 2009 Apr; 77(4):1606-12. Gentil K, Pearlman E. PMID: 19168746; PMCID: PMC2663151.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    79. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1247-54. Sun Y, Pearlman E. PMID: 18936141; PMCID: PMC3909488.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    80. MyD88 regulation of Fusarium keratitis is dependent on TLR4 and IL-1R1 but not TLR2. J Immunol. 2008 Jul 01; 181(1):593-600. Tarabishy AB, Aldabagh B, Sun Y, Imamura Y, Mukherjee PK, Lass JH, Ghannoum MA, Pearlman E. PMID: 18566426; PMCID: PMC3909484.
      View in: PubMed   Mentions: 41     Fields:    Translation:Animals
    81. Toll-like receptors at the ocular surface. Ocul Surf. 2008 Jul; 6(3):108-16. Pearlman E, Johnson A, Adhikary G, Sun Y, Chinnery HR, Fox T, Kester M, McMenamin PG. PMID: 18781257; PMCID: PMC3403823.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    82. Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro. Am J Pathol. 2008 Jul; 173(1):144-53. Lin M, Jackson P, Tester AM, Diaconu E, Overall CM, Blalock JE, Pearlman E. PMID: 18556780; PMCID: PMC2438292.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    83. Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide. J Leukoc Biol. 2008 Jun; 83(6):1512-21. Sun Y, Fox T, Adhikary G, Kester M, Pearlman E. PMID: 18372342; PMCID: PMC3584160.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    84. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. J Leukoc Biol. 2008 Apr; 83(4):991-7. Adhikary G, Sun Y, Pearlman E. PMID: 18218857; PMCID: PMC3959745.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    85. MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase. J Biol Chem. 2008 Feb 15; 283(7):3988-96. Johnson AC, Li X, Pearlman E. PMID: 18057004.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    86. Fusarium and Candida albicans biofilms on soft contact lenses: model development, influence of lens type, and susceptibility to lens care solutions. Antimicrob Agents Chemother. 2008 Jan; 52(1):171-82. Imamura Y, Chandra J, Mukherjee PK, Lattif AA, Szczotka-Flynn LB, Pearlman E, Lass JH, O'Donnell K, Ghannoum MA. PMID: 17999966; PMCID: PMC2223913.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimals
    87. Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. J Biol Chem. 2007 Dec 07; 282(49):35502-9. Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E. PMID: 17911102; PMCID: PMC3909483.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    88. Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis. Infect Immun. 2007 Dec; 75(12):5908-15. Gillette-Ferguson I, Daehnel K, Hise AG, Sun Y, Carlson E, Diaconu E, McGarry HF, Taylor MJ, Pearlman E. PMID: 17875630; PMCID: PMC2168349.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    89. Filaria/Wolbachia activation of dendritic cells and development of Th1-associated responses is dependent on Toll-like receptor 2 in a mouse model of ocular onchocerciasis (river blindness). Parasite Immunol. 2007 Sep; 29(9):455-65. Daehnel K, Gillette-Ferguson I, Hise AG, Diaconu E, Harling MJ, Heinzel FP, Pearlman E. PMID: 17727569.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    90. Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM. J Immunol. 2007 Jan 15; 178(2):1068-76. Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E. PMID: 17202370.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    91. Onchocerca volvulus, Wolbachia and river blindness. Chem Immunol Allergy. 2007; 92:254-265. Pearlman E, Gillette-Ferguson I. PMID: 17264501.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    92. CXCL1/KC and CXCL5/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis. J Leukoc Biol. 2007 Mar; 81(3):786-92. Lin M, Carlson E, Diaconu E, Pearlman E. PMID: 17110418; PMCID: PMC3909486.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    93. Staphylococcus aureus-induced corneal inflammation is dependent on Toll-like receptor 2 and myeloid differentiation factor 88. Infect Immun. 2006 Sep; 74(9):5325-32. Sun Y, Hise AG, Kalsow CM, Pearlman E. PMID: 16926427; PMCID: PMC1594867.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    94. Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88. Infect Immun. 2006 Apr; 74(4):2442-5. Gillette-Ferguson I, Hise AG, Sun Y, Diaconu E, McGarry HF, Taylor MJ, Pearlman E. PMID: 16552075; PMCID: PMC1418907.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    95. Toll-like receptors in the cornea. Ocul Surf. 2005 Oct; 3(4 Suppl):S187-9. Johnson A, Pearlman E. PMID: 17216116.
      View in: PubMed   Mentions: 8     Fields:    
    96. Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Invest Ophthalmol Vis Sci. 2005 Feb; 46(2):589-95. Johnson AC, Heinzel FP, Diaconu E, Sun Y, Hise AG, Golenbock D, Lass JH, Pearlman E. PMID: 15671286.
      View in: PubMed   Mentions: 84     Fields:    Translation:AnimalsCells
    97. Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness). Infect Immun. 2004 Oct; 72(10):5687-92. Gillette-Ferguson I, Hise AG, McGarry HF, Turner J, Esposito A, Sun Y, Diaconu E, Taylor MJ, Pearlman E. PMID: 15385467; PMCID: PMC517527.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    98. The role of endosymbiotic Wolbachia bacteria in filarial disease. Cell Microbiol. 2004 Feb; 6(2):97-104. Hise AG, Gillette-Ferguson I, Pearlman E. PMID: 14706096.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    99. Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for endosymbiotic Wolbachia bacteria. Med Microbiol Immunol. 2003 Feb; 192(1):57-60. Pearlman E. PMID: 12592565.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    100. Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): a novel role for TLR4 and endosymbiotic Wolbachia bacteria. J Endotoxin Res. 2003; 9(6):390-4. Hise AG, Gillette-Ferguson I, Pearlman E. PMID: 14733727.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    101. Regulation of endotoxin-induced keratitis by PECAM-1, MIP-2, and toll-like receptor 4. Invest Ophthalmol Vis Sci. 2002 Jul; 43(7):2278-84. Khatri S, Lass JH, Heinzel FP, Petroll WM, Gomez J, Diaconu E, Kalsow CM, Pearlman E. PMID: 12091428.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    102. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science. 2002 Mar 08; 295(5561):1892-5. Saint André Av, Blackwell NM, Hall LR, Hoerauf A, Brattig NW, Volkmann L, Taylor MJ, Ford L, Hise AG, Lass JH, Diaconu E, Pearlman E. PMID: 11884755.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansAnimalsCells
    103. A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation. J Immunol. 2001 Jul 15; 167(2):919-25. Hall LR, Diaconu E, Pearlman E. PMID: 11441099.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    104. Distinct roles for PECAM-1, ICAM-1, and VCAM-1 in recruitment of neutrophils and eosinophils to the cornea in ocular onchocerciasis (river blindness). J Immunol. 2001 Jun 01; 166(11):6795-801. Kaifi JT, Diaconu E, Pearlman E. PMID: 11359838.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    105. CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). J Immunol. 2001 Mar 15; 166(6):4035-41. Hall LR, Diaconu E, Patel R, Pearlman E. PMID: 11238651.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    106. Reciprocal immunomodulatory effects of gamma interferon and interleukin-4 on filaria-induced airway hyperresponsiveness. Infect Immun. 2001 Mar; 69(3):1463-8. Mehlotra RK, Hall LR, Haxhiu MA, Pearlman E. PMID: 11179313; PMCID: PMC98042.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    107. Immune mechanisms in Onchocerca volvulus-mediated corneal disease (river blindness). Parasite Immunol. 2000 Dec; 22(12):625-31. Pearlman E, Hall LR. PMID: 11123754.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    108. Impaired eosinophil recruitment to the cornea in P-selectin-deficient mice in Onchocerca volvulus keratitis (River blindness). Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3856-61. Kaifi JT, Hall LR, Diaz C, Sypek J, Diaconu E, Lass JH, Pearlman E. PMID: 11053286.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    109. CD4(+) depletion selectively inhibits eosinophil recruitment to the cornea and abrogates Onchocerca volvulus keratitis (River blindness). Infect Immun. 2000 Sep; 68(9):5459-61. Hall LR, Kaifi JT, Diaconu E, Pearlman E. PMID: 10948184; PMCID: PMC101818.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    110. IFN-gamma is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. J Immunol. 2000 Jan 15; 164(2):779-85. Martin DL, King CL, Pearlman E, Strine E, Heinzel FP. PMID: 10623823.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    111. An essential role for antibody in neutrophil and eosinophil recruitment to the cornea: B cell-deficient (microMT) mice fail to develop Th2-dependent, helminth-mediated keratitis. J Immunol. 1999 Nov 01; 163(9):4970-5. Hall LR, Lass JH, Diaconu E, Strine ER, Pearlman E. PMID: 10528201.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    112. Eotaxin expression in Onchocerca volvulus-induced dermatitis after topical application of diethylcarbamazine. J Infect Dis. 1999 Oct; 180(4):1394-7. Pearlman E, Toé L, Boatin BA, Gilles AA, Higgins AW, Unnasch TR. PMID: 10479181.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    113. Temporal recruitment of neutrophils and eosinophils to the skin in a murine model for onchocercal dermatitis. Am J Trop Med Hyg. 1999 Jul; 61(1):14-8. Pearlman E, Garhart CA, Grand DJ, Diaconu E, Strine ER, Hall LR. PMID: 10432048.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    114. Pathogenesis of onchocercal keratitis (River blindness). Clin Microbiol Rev. 1999 Jul; 12(3):445-53. Hall LR, Pearlman E. PMID: 10398675; PMCID: PMC100248.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    115. Type 2 immune deviation has differential effects on alloreactive CD4+ and CD8+ T cells. J Immunol. 1998 Nov 15; 161(10):5236-44. Matesic D, Valujskikh A, Pearlman E, Higgins AW, Gilliam AC, Heeger PS. PMID: 9820495.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    116. Interleukin-12 suppresses filaria-induced pulmonary eosinophilia, deposition of major basic protein and airway hyperresponsiveness. Parasite Immunol. 1998 Oct; 20(10):455-62. Mehlotra RK, Hall LR, Higgins AW, Dreshaj IA, Haxhiu MA, Kazura JW, Pearlman E. PMID: 9797506; PMCID: PMC4469192.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    117. An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness. Infect Immun. 1998 Sep; 66(9):4425-30. Hall LR, Mehlotra RK, Higgins AW, Haxhiu MA, Pearlman E. PMID: 9712797; PMCID: PMC108535.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    118. The role of eosinophils and neutrophils in helminth-induced keratitis. Invest Ophthalmol Vis Sci. 1998 Jun; 39(7):1176-82. Pearlman E, Hall LR, Higgins AW, Bardenstein DS, Diaconu E, Hazlett FE, Albright J, Kazura JW, Lass JH. PMID: 9620077.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    119. Identification of an epitope of a recombinant Onchocerca volvulus protein that induces corneal pathology. Mol Biochem Parasitol. 1997 Oct; 89(1):123-35. Pearlman E, Diaconu E, Hazlett FE, Merriweather A, Unnasch TR. PMID: 9297706.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    120. Pleomorphism of stromal eosinophils in murine experimental onchocercal keratitis. Ocul Immunol Inflamm. 1997 Sep; 5(3):157-63. Bardenstein DS, Lass JH, Kazura JW, Pearlman E. PMID: 9326760.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    121. B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression. J Immunol. 1997 Jun 15; 158(12):5914-20. Subramanian G, Kazura JW, Pearlman E, Jia X, Malhotra I, King CL. PMID: 9190944.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    122. IL-12 exacerbates helminth-mediated corneal pathology by augmenting inflammatory cell recruitment and chemokine expression. J Immunol. 1997 Jan 15; 158(2):827-33. Pearlman E, Lass JH, Bardenstein DS, Diaconu E, Hazlett FE, Albright J, Higgins AW, Kazura JW. PMID: 8993000.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    123. Onchocerca volvulus-mediated keratitis: cytokine production by IL-4-deficient mice. Exp Parasitol. 1996 Nov; 84(2):274-81. Pearlman E, Lass JH, Bardenstein DS, Diaconu E, Hazlett FE, Albright J, Higgins AW, Kazura JW. PMID: 8932777.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    124. Expression of hyaluronidase by tumor cells induces angiogenesis in vivo. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7832-7. Liu D, Pearlman E, Diaconu E, Guo K, Mori H, Haqqi T, Markowitz S, Willson J, Sy MS. PMID: 8755562; PMCID: PMC38834.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    125. Experimental onchocercal keratitis. Parasitol Today. 1996 Jul; 12(7):261-7. Pearlman E. PMID: 15275190.
      View in: PubMed   Mentions: 2     Fields:    
    126. Interleukin 4 and T helper type 2 cells are required for development of experimental onchocercal keratitis (river blindness). J Exp Med. 1995 Oct 01; 182(4):931-40. Pearlman E, Lass JH, Bardenstein DS, Kopf M, Hazlett FE, Diaconu E, Kazura JW. PMID: 7561696; PMCID: PMC2192285.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    127. Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice. J Immunol. 1995 Jul 15; 155(2):730-9. Heinzel FP, Rerko RM, Ahmed F, Pearlman E. PMID: 7608551.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    128. IL-12 modulation of T helper responses to the filarial helminth, Brugia malayi. J Immunol. 1995 May 01; 154(9):4658-64. Pearlman E, Heinzel FP, Hazlett FE, Kazura JW. PMID: 7722318.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    129. Class II major histocompatibility complex molecule expression on murine eosinophils activated in vivo by Brugia malayi. Infect Immun. 1993 Dec; 61(12):5410-2. Mawhorter SD, Pearlman E, Kazura JW, Boom WH. PMID: 7901170; PMCID: PMC281333.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    130. Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses. J Immunol. 1993 Nov 01; 151(9):4857-64. Pearlman E, Kazura JW, Hazlett FE, Boom WH. PMID: 8409444.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCellsPHPublic Health
    131. Induction of murine T-helper-cell responses to the filarial nematode Brugia malayi. Infect Immun. 1993 Mar; 61(3):1105-12. Pearlman E, Hazlett FE, Boom WH, Kazura JW. PMID: 8094378; PMCID: PMC302845.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    132. Brugia malayi: acquired resistance to microfilariae in BALB/c mice correlates with local Th2 responses. Exp Parasitol. 1993 Mar; 76(2):200-8. Pearlman E, Kroeze WK, Hazlett FE, Chen SS, Mawhorter SD, Boom WH, Kazura JW. PMID: 8454029.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    133. Antigenicity of a protective recombinant filarial protein in human bancroftian filariasis. J Infect Dis. 1992 Dec; 166(6):1453-7. Kazura JW, Hazlett FE, Pearlman E, Day K, el-Zeiny A, Nilsen TW, Alpers MP. PMID: 1431265.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    134. Protective efficacy of a cloned Brugia malayi antigen in a mouse model of microfilaremia. J Immunol. 1990 Oct 01; 145(7):2260-4. Kazura JW, Maroney PA, Pearlman E, Nilsen TW. PMID: 2398279.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
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