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Nelson, Edward L

TitleAssociate Professor
InstitutionUniversity of California, Irvine
DepartmentMedicine
Address1001 Health Sciences Road
CA 92697-3950
Phone(714) 456-5153
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    Collapse Research 
    Collapse Research Activities and Funding
    Neoadjuvant photodynamic immunomodulation for colon cancer
    NIH/NCI R21CA153594Aug 1, 2010 - Jul 31, 2013
    Role: Principal Investigator
    Application of a Novel Nanotechnology for Molecular Profiling of Tumor Cellular E
    NIH/NCI R21CA132039Jun 20, 2008 - Apr 30, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Qiu X, Lombardo JA, Westerhof TM, Pennell M, Ng A, Alshetaiwi H, Luna BM, Nelson E, Kessenbrock K, Hui EE, Haun JB. Microfluidic filter device with nylon mesh membranes efficiently dissociates cell aggregates and digested tissue into single cells. Lab Chip. 2018 Aug 09. PMID: 30090895.
      View in: PubMed
    2. Bagaev A, Pichugin A, Nelson E, Agadjanyan MG, Ghochikyan A, Ataullakhanov RI. Anticancer Mechanisms in Two Murine Bone Marrow-Derived Dendritic Cell Subsets Activated with TLR4 Agonists. J Immunol. 2018 Apr 15; 200(8):2656-2669. PMID: 29500244.
      View in: PubMed
    3. Qiu X, Huang JH, Westerhof TM, Lombardo JA, Henrikson KM, Pennell M, Pourfard PP, Nelson E, Nath P, Haun JB. Microfluidic channel optimization to improve hydrodynamic dissociation of cell aggregates and tissue. Sci Rep. 2018 Feb 09; 8(1):2774. PMID: 29426941.
      View in: PubMed
    4. Neek M, Tucker JA, Kim TI, Molino NM, Nelson E, Wang SW. Co-delivery of human cancer-testis antigens with adjuvant in protein nanoparticles induces higher cell-mediated immune responses. Biomaterials. 2018 02; 156:194-203. PMID: 29202325.
      View in: PubMed
    5. Westerhof TM, Cox-Muranami WA, Li GP, Bachman M, Fan H, Nelson E. Highly efficient cellular cloning using Ferro-core Micropallet Arrays. Sci Rep. 2017 Oct 12; 7(1):13081. PMID: 29026113.
      View in: PubMed
    6. Qiu X, Westerhof TM, Karunaratne AA, Werner EM, Pourfard PP, Nelson E, Hui EE, Haun JB. Microfluidic device for rapid digestion of tissues into cellular suspensions. Lab Chip. 2017 09 26; 17(19):3300-3309. PMID: 28850139.
      View in: PubMed
    7. Hinkle P, Westerhof TM, Qiu Y, Mallin DJ, Wallace ML, Nelson E, Taborek P, Siwy ZS. A hybrid resistive pulse-optical detection platform for microfluidic experiments. Sci Rep. 2017 Aug 31; 7(1):10173. PMID: 28860641.
      View in: PubMed
    8. Molino NM, Neek M, Tucker JA, Nelson E, Wang SW. Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells. ACS Biomater Sci Eng. 2017 Apr 10; 3(4):496-501. PMID: 28989957.
      View in: PubMed
    9. Westerhof TM, Li GP, Bachman M, Nelson E. Multicolor Immunofluorescent Imaging of Complex Cellular Mixtures on Micropallet Arrays Enables the Identification of Single Cells of Defined Phenotype. Adv Healthc Mater. 2016 Apr 06; 5(7):767-71. PMID: 26924570.
      View in: PubMed
    10. Iyer NS, Osann K, Hsieh S, Tucker JA, Monk BJ, Nelson E, Wenzel L. Health Behaviors in Cervical Cancer Survivors and Associations with Quality of Life. Clin Ther. 2016 Mar; 38(3):467-75. PMID: 26926320; PMCID: PMC4799758 [Available on 03/01/17].
    11. Molino NM, Neek M, Tucker JA, Nelson E, Wang SW. Viral-mimicking protein nanoparticle vaccine for eliciting anti-tumor responses. Biomaterials. 2016 Apr; 86:83-91. PMID: 26894870; PMCID: PMC4775383 [Available on 04/01/17].
    12. Cox-Muranami WA, Nelson E, Li GP, Bachman M. Large area magnetic micropallet arrays for cell colony sorting. Lab Chip. 2016 Jan 07; 16(1):172-81. PMID: 26606460.
      View in: PubMed
    13. Wenzel L, Osann K, Hsieh S, Tucker JA, Monk BJ, Nelson E. Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial. J Clin Oncol. 2015 Apr 01; 33(10):1171-9. PMID: 25713429; PMCID: PMC4372853.
    14. Ghochikyan A, Pichugin A, Bagaev A, Davtyan A, Hovakimyan A, Tukhvatulin A, Davtyan H, Shcheblyakov D, Logunov D, Chulkina M, Savilova A, Trofimov D, Nelson E, Agadjanyan MG, Ataullakhanov RI. Targeting TLR-4 with a novel pharmaceutical grade plant derived agonist, Immunomax®, as a therapeutic strategy for metastatic breast cancer. J Transl Med. 2014 Nov 29; 12:322. PMID: 25432242; PMCID: PMC4261251.
    15. Osann K, Hsieh S, Nelson E, Monk BJ, Chase D, Cella D, Wenzel L. Factors associated with poor quality of life among cervical cancer survivors: implications for clinical care and clinical trials. Gynecol Oncol. 2014 Nov; 135(2):266-72. PMID: 25192629; PMCID: PMC4479396.
    16. Luo J, Nelson E, Li GP, Bachman M. Microfluidic dielectrophoretic sorter using gel vertical electrodes. Biomicrofluidics. 2014 May; 8(3):034105. PMID: 24926390; PMCID: PMC4032422.
    17. Molino NM, Anderson AK, Nelson E, Wang SW. Biomimetic protein nanoparticles facilitate enhanced dendritic cell activation and cross-presentation. ACS Nano. 2013 Nov 26; 7(11):9743-52. PMID: 24090491; PMCID: PMC3893022.
    18. Ghochikyan A, Davtyan A, Hovakimyan A, Davtyan H, Poghosyan A, Bagaev A, Ataullakhanov RI, Nelson E, Agadjanyan MG. Primary 4T1 tumor resection provides critical "window of opportunity" for immunotherapy. Clin Exp Metastasis. 2014 Feb; 31(2):185-98. PMID: 24096737; PMCID: PMC3946940.
    19. Martinez M, Ono N, Planutiene M, Planutis K, Nelson E, Holcombe RF. Correction: Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy. Cancer Cell Int. 2013 Aug 15; 13(1):80. PMID: 23945146; PMCID: PMC3751084.
    20. Wenzel L, Osann K, Lester J, Kurz R, Hsieh S, Nelson E, Karlan B. Biopsychological stress factors in BRCA mutation carriers. Psychosomatics. 2012 Nov-Dec; 53(6):582-90. PMID: 23157996; PMCID: PMC4572843.
    21. Biegler KA, Anderson AK, Wenzel LB, Osann K, Nelson E. Longitudinal change in telomere length and the chronic stress response in a randomized pilot biobehavioral clinical study: implications for cancer prevention. Cancer Prev Res (Phila). 2012 Oct; 5(10):1173-82. PMID: 22827974; PMCID: PMC4479406.
    22. Martinez M, Ono N, Planutiene M, Planutis K, Nelson E, Holcombe RF. Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy. Cancer Cell Int. 2012 Jan 23; 12(1):2. PMID: 22270330; PMCID: PMC3283445.
    23. Mkrtichyan M, Ghochikyan A, Davtyan H, Movsesyan N, Loukinov D, Lobanenkov V, Cribbs DH, Laust AK, Nelson E, Agadjanyan MG. Cancer-testis antigen, BORIS based vaccine delivered by dendritic cells is extremely effective against a very aggressive and highly metastatic mouse mammary carcinoma. Cell Immunol. 2011; 270(2):188-97. PMID: 21641588; PMCID: PMC3156877.
    24. Casey SC, Nelson E, Turco GM, Janes MR, Fruman DA, Blumberg B. B-1 cell lymphoma in mice lacking the steroid and xenobiotic receptor, SXR. Mol Endocrinol. 2011 Jun; 25(6):933-43. PMID: 21436254; PMCID: PMC3100607.
    25. Osann K, Wenzel L, Dogan A, Hsieh S, Chase DM, Sappington S, Monk BJ, Nelson E. Recruitment and retention results for a population-based cervical cancer biobehavioral clinical trial. Gynecol Oncol. 2011 Jun 01; 121(3):558-64. PMID: 21402400; PMCID: PMC4572839.
    26. Denney JM, Nelson E, Wadhwa PD, Waters TP, Mathew L, Chung EK, Goldenberg RL, Culhane JF. Longitudinal modulation of immune system cytokine profile during pregnancy. Cytokine. 2011 Feb; 53(2):170-7. PMID: 21123081; PMCID: PMC4610033.
    27. Gunn NM, Bachman M, Li GP, Nelson E. Fabrication and biological evaluation of uniform extracellular matrix coatings on discontinuous photolithography generated micropallet arrays. J Biomed Mater Res A. 2010 Nov; 95(2):401-12. PMID: 20648537; PMCID: PMC2981065.
    28. Gunn NM, Chang R, Westerhof T, Li GP, Bachman M, Nelson E. Ferromagnetic micropallets for magnetic capture of single adherent cells. Langmuir. 2010 Nov 16; 26(22):17703-11. PMID: 20968293; PMCID: PMC2981060.
    29. Fraser DA, Laust AK, Nelson E, Tenner AJ. C1q differentially modulates phagocytosis and cytokine responses during ingestion of apoptotic cells by human monocytes, macrophages, and dendritic cells. J Immunol. 2009 Nov 15; 183(10):6175-85. PMID: 19864605; PMCID: PMC2843563.
    30. Nishimoto KP, Laust AK, Nelson E. A human dendritic cell subset receptive to the Venezuelan equine encephalitis virus-derived replicon particle constitutively expresses IL-32. J Immunol. 2008 Sep 15; 181(6):4010-8. PMID: 18768856.
      View in: PubMed
    31. Entringer S, Kumsta R, Nelson E, Hellhammer DH, Wadhwa PD, Wüst S. Influence of prenatal psychosocial stress on cytokine production in adult women. Dev Psychobiol. 2008 Sep; 50(6):579-87. PMID: 18683180; PMCID: PMC2838479.
    32. Sur BW, Nguyen P, Sun CH, Tromberg BJ, Nelson E. Immunophototherapy using PDT combined with rapid intratumoral dendritic cell injection. Photochem Photobiol. 2008 Sep-Oct; 84(5):1257-64. PMID: 18435703; PMCID: PMC3940280.
    33. Nelson E, Wenzel LB, Osann K, Dogan-Ates A, Chantana N, Reina-Patton A, Laust AK, Nishimoto KP, Chicz-DeMet A, du Pont N, Monk BJ. Stress, immunity, and cervical cancer: biobehavioral outcomes of a randomized clinical trial [corrected]. Clin Cancer Res. 2008 Apr 01; 14(7):2111-8. PMID: 18381952; PMCID: PMC4572837.
    34. Moore JC, Zhao X, Nelson E. Concomitant sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman Disease) and diffuse large B-cell lymphoma: a case report. J Med Case Rep. 2008 Mar 05; 2:70. PMID: 18321383; PMCID: PMC2270859.
    35. Nishimoto KP, Newkirk D, Hou S, Fruehauf J, Nelson E. Fluorescence activated cell sorting (FACS) using RNAlater to minimize RNA degradation and perturbation of mRNA expression from cells involved in initial host microbe interactions. J Microbiol Methods. 2007 Jul; 70(1):205-8. PMID: 17512621.
      View in: PubMed
    36. Laust AK, Sur BW, Wang K, Hubby B, Smith JF, Nelson E. VRP immunotherapy targeting neu: treatment efficacy and evidence for immunoediting in a stringent rat mammary tumor model. Breast Cancer Res Treat. 2007 Dec; 106(3):371-82. PMID: 17351745.
      View in: PubMed
    37. Nishimoto KP, Laust AK, Wang K, Kamrud KI, Hubby B, Smith JF, Nelson E. Restricted and selective tropism of a Venezuelan equine encephalitis virus-derived replicon vector for human dendritic cells. Viral Immunol. 2007; 20(1):88-104. PMID: 17425424.
      View in: PubMed
    38. Zhou C, Tabb MM, Nelson E, Grün F, Verma S, Sadatrafiei A, Lin M, Mallick S, Forman BM, Thummel KE, Blumberg B. Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation. J Clin Invest. 2006 Aug; 116(8):2280-2289. PMID: 16841097; PMCID: PMC1501109.
    39. Wang K, Nishimoto KP, Mehta RS, Nelson E. An alternative flow cytometry strategy for peripheral blood dendritic cell enumeration in the setting of repetitive GM-CSF dosing. J Transl Med. 2006 Apr 24; 4:18. PMID: 16635268; PMCID: PMC1463012.
    40. dupont NC, Wang K, Wadhwa PD, Culhane JF, Nelson E. Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: determinations of a panel of nine cytokines in clinical sample culture supernatants. J Reprod Immunol. 2005 Aug; 66(2):175-91. PMID: 16029895.
      View in: PubMed
    41. Nelson E, Prieto D, Alexander TG, Pushko P, Lofts LA, Rayner JO, Kamrud KI, Fralish B, Smith JF. Venezuelan equine encephalitis replicon immunization overcomes intrinsic tolerance and elicits effective anti-tumor immunity to the 'self' tumor-associated antigen, neu in a rat mammary tumor model. Breast Cancer Res Treat. 2003 Dec; 82(3):169-83. PMID: 14703064.
      View in: PubMed