Thomas Edward Lane

Title(s)Professor, Neurobiology & Behavior
SchoolSchool of Biological Sciences
Address2205 McGaugh Hall
Zot 4550
Irvine CA 92697
Phone(949) 824-1360
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Engineered AAV vectors for combinatorial treatment of rare genetic brain diseases
    NIH R01FD007478Sep 1, 2021 - Aug 31, 2024
    Role: Co-Principal Investigator
    FASEB's The Translational Neuroimmunology Conference: From Mechanisms to Therapeutics.
    NIH R13NS116795Jul 1, 2020 - Jun 30, 2021
    Role: Principal Investigator
    Defining mechanisms of disease and repair in a viral model of multiple sclerosis
    NIH R35NS116835May 1, 2020 - Apr 30, 2028
    Role: Principal Investigator
    Viral-induced axonopathy: mechanisms of damage and repair
    NIH R01NS091939Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Human neural precursor cell-mediated therapy in a viral model of demyelination
    NIH R01NS092042May 15, 2015 - Mar 31, 2021
    Role: Principal Investigator
    Viral-induced demyelination and neural stem cell-mediated remyelination
    NIH R01NS074987Jul 1, 2011 - Jun 30, 2017
    Role: Principal Investigator
    Chemokines and Viral-Induced Neurologic Disease
    NIH R01NS041249Apr 1, 2001 - Aug 31, 2021
    Role: Principal Investigator
    PATHOLOGICAL MECHANISMS OF DEMYELINATION
    NIH R29NS037336Feb 1, 1998 - Jan 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microglia influence immune responses and restrict neurologic disease in response to central nervous system infection by a neurotropic murine coronavirus. Front Cell Neurosci. 2023; 17:1291255. Syage A, Pachow C, Cheng Y, Mangale V, Green KN, Lane TE. PMID: 38099152; PMCID: PMC10719854.
      View in: PubMed   Mentions:
    2. OCA-B promotes autoimmune demyelination through control of stem-like CD4 + T cells. bioRxiv. 2023 Nov 30. Hughes EP, Syage A, Mehrabad EM, Lane TE, Spike BT, Tantin D. PMID: 38076925; PMCID: PMC10705450.
      View in: PubMed   Mentions:
    3. Ablation of microglia following infection of the central nervous system with a neurotropic murine coronavirus infection leads to increased demyelination and impaired remyelination. J Neuroimmunol. 2023 08 15; 381:578133. Cheng Y, Javonillo DI, Pachow C, Scarfone VM, Fernandez K, Walsh CM, Green KN, Lane TE. PMID: 37352687.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Presentation of Human Neural Stem Cell Antigens Drives Regulatory T Cell Induction. J Immunol. 2023 06 01; 210(11):1677-1686. Greilach SA, McIntyre LL, Nguyen QH, Silva J, Kessenbrock K, Lane TE, Walsh CM. PMID: 37083696; PMCID: PMC10192095.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Sustained Infiltration of Neutrophils Into the CNS Results in Increased Demyelination in a Viral-Induced Model of Multiple Sclerosis. Front Immunol. 2022; 13:931388. Skinner DD, Syage AR, Olivarria GM, Stone C, Hoglin B, Lane TE. PMID: 36248905; PMCID: PMC9562915.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. MAC2 is a long-lasting marker of peripheral cell infiltrates into the mouse CNS after bone marrow transplantation and coronavirus infection. Glia. 2022 05; 70(5):875-891. Hohsfield LA, Tsourmas KI, Ghorbanian Y, Syage AR, Jin Kim S, Cheng Y, Furman S, Inlay MA, Lane TE, Green KN. PMID: 35025109; PMCID: PMC8930563.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. Evaluating the role of chemokines and chemokine receptors involved in coronavirus infection. Expert Rev Clin Immunol. 2022 01; 18(1):57-66. Olivarria G, Lane TE. PMID: 34964406; PMCID: PMC8851429.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    8. Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice. J Virol. 2022 02 23; 96(4):e0196921. Olivarria GM, Cheng Y, Furman S, Pachow C, Hohsfield LA, Smith-Geater C, Miramontes R, Wu J, Burns MS, Tsourmas KI, Stocksdale J, Manlapaz C, Yong WH, Teijaro J, Edwards R, Green KN, Thompson LM, Lane TE. PMID: 34935438; PMCID: PMC8865461.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice. bioRxiv. 2021 Nov 17. Olivarria GM, Cheng Y, Furman S, Pachow C, Hohsfield LA, Smith-Geater C, Miramontes R, Wu J, Burns MS, Tsourmas KI, Stocksdale J, Manlapaz C, Yong WH, Teijaro J, Edwards R, Green KN, Thompson LM, Lane TE. PMID: 34816260; PMCID: PMC8609895.
      View in: PubMed   Mentions:
    10. Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus. J Virol. 2020 11 23; 94(24). Syage AR, Ekiz HA, Skinner DD, Stone C, O'Connell RM, Lane TE. PMID: 32999036; PMCID: PMC7925182.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. The 2020 FASEB Science Research Conference on Translational Neuroimmunology: From Mechanisms to Therapeutics, June 29-30, 2020. FASEB J. 2020 11; 34(11):14064-14068. Lane TE, Segal BM. PMID: 33001447; PMCID: PMC7606708.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system. Glia. 2020 11; 68(11):2345-2360. Mangale V, Syage AR, Ekiz HA, Skinner DD, Cheng Y, Stone CL, Brown RM, O'Connell RM, Green KN, Lane TE. PMID: 32449994; PMCID: PMC7280614.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    13. Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant. Neurobiol Dis. 2020 07; 140:104868. McIntyre LL, Greilach SA, Othy S, Sears-Kraxberger I, Wi B, Ayala-Angulo J, Vu E, Pham Q, Silva J, Dang K, Rezk F, Steward O, Cahalan MD, Lane TE, Walsh CM. PMID: 32276110; PMCID: PMC7253332.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    14. Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis. J Virol. 2019 09 15; 93(18). Marro BS, Skinner DD, Cheng Y, Grist JJ, Dickey LL, Eckman E, Stone C, Liu L, Ransohoff RM, Lane TE. PMID: 31243125; PMCID: PMC6714798.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease. Viral Immunol. 2019 Jan/Feb; 32(1):25-37. Skinner D, Marro BS, Lane TE. PMID: 30109979; PMCID: PMC6350065.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System. Infect Immun. 2018 03; 86(3). Denham ST, Verma S, Reynolds RC, Worne CL, Daugherty JM, Lane TE, Brown JCS. PMID: 29203547; PMCID: PMC5820953.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    17. MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease. J Neuroinflammation. 2016 09 07; 13(1):240. Dickey LL, Worne CL, Glover JL, Lane TE, O'Connell RM. PMID: 27604627; PMCID: PMC5015201.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    18. Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis. PLoS One. 2016; 11(6):e0157620. Plaisted WC, Zavala A, Hingco E, Tran H, Coleman R, Lane TE, Loring JF, Walsh CM. PMID: 27310015; PMCID: PMC4911106.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    19. Neutrophils and viral-induced neurologic disease. Clin Immunol. 2018 04; 189:52-56. Grist JJ, Marro B, Lane TE. PMID: 27288312; PMCID: PMC5145788.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1316-25. Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. PMID: 26884167; PMCID: PMC4780638.
      View in: PubMed   Mentions: 180     Fields:    Translation:HumansAnimalsCells
    21. Inducible Expression of CXCL1 within the Central Nervous System Amplifies Viral-Induced Demyelination. J Immunol. 2016 Feb 15; 196(4):1855-64. Marro BS, Grist JJ, Lane TE. PMID: 26773148; PMCID: PMC4742654.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    22. Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination. Am J Pathol. 2015 Oct; 185(10):2819-32. Blanc CA, Grist JJ, Rosen H, Sears-Kraxberger I, Steward O, Lane TE. PMID: 26435414; PMCID: PMC4607760.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    23. Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice. Stroke. 2015 Oct; 46(10):2916-25. Herz J, Sabellek P, Lane TE, Gunzer M, Hermann DM, Doeppner TR. PMID: 26337969; PMCID: PMC4589522.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    24. Two-photon imaging of cellular dynamics in the mouse spinal cord. J Vis Exp. 2015 Feb 22; (96). Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD. PMID: 25742043; PMCID: PMC4354666.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    25. Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. Expert Rev Neurother. 2014 Oct; 14(10):1169-79. Marro BS, Blanc CA, Loring JF, Cahalan MD, Lane TE. PMID: 25245576; PMCID: PMC4232205.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    26. Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis. Stem Cells. 2014 Oct; 32(10):2690-701. Weinger JG, Plaisted WC, Maciejewski SM, Lanier LL, Walsh CM, Lane TE. PMID: 24898518; PMCID: PMC4165828.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    27. FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. J Neuroinflammation. 2014 Aug 20; 11:138. Blanc CA, Rosen H, Lane TE. PMID: 25138356; PMCID: PMC4148542.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease. Front Cell Neurosci. 2014; 8:165. Hosking MP, Lane TE. PMID: 24987333; PMCID: PMC4060560.
      View in: PubMed   Mentions: 5  
    29. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2349-55. Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. PMID: 24843159; PMCID: PMC4050611.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    30. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 03; 2(6):825-37. Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. PMID: 24936469; PMCID: PMC4050357.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    31. Spinal cord injury, immunodepression, and antigenic challenge. Semin Immunol. 2014 Oct; 26(5):415-20. Held KS, Lane TE. PMID: 24747011; PMCID: PMC5029282.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    32. T cell mediated suppression of neurotropic coronavirus replication in neural precursor cells. Virology. 2014 Jan 20; 449:235-43. Plaisted WC, Weinger JG, Walsh CM, Lane TE. PMID: 24418558; PMCID: PMC3894587.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    33. WSX-1 signalling inhibits CD4⁺ T cell migration to the liver during malaria infection by repressing chemokine-independent pathways. PLoS One. 2013; 8(11):e78486. Villegas-Mendez A, Gwyer Findlay E, de Souza JB, Grady LM, Saris CJ, Lane TE, Riley EM, Couper KN. PMID: 24244314; PMCID: PMC3820588.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    34. Intraspinal transplantation of mouse and human neural precursor cells. Curr Protoc Stem Cell Biol. 2013 Sep 20; 26:2D.16.1-2D.16.16. Weinger JG, Chen L, Coleman R, Leang R, Plaisted WC, Loring JF, Lane TE. PMID: 24510791; PMCID: PMC3920297.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    35. The chemokine receptor CXCR2 and coronavirus-induced neurologic disease. Virology. 2013 Jan 05; 435(1):110-7. Weinger JG, Marro BS, Hosking MP, Lane TE. PMID: 23217621; PMCID: PMC3522860.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    36. MHC mismatch results in neural progenitor cell rejection following spinal cord transplantation in a model of viral-induced demyelination. Stem Cells. 2012 Nov; 30(11):2584-95. Weinger JG, Weist BM, Plaisted WC, Klaus SM, Walsh CM, Lane TE. PMID: 22969049; PMCID: PMC3479361.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    37. Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis. J Neuroimmunol. 2013 Jan 15; 254(1-2):110-6. Tirotta E, Duncker P, Oak J, Klaus S, Tsukamoto MR, Gov L, Lane TE. PMID: 23102608; PMCID: PMC3534940.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    38. Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections. J Virol. 2012 Nov; 86(21):11416-24. Zhao J, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB, Perlman S. PMID: 22915814; PMCID: PMC3486278.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    39. IFN-γ-induced apoptosis of human embryonic stem cell derived oligodendrocyte progenitor cells is restricted by CXCR2 signaling. Stem Cell Res. 2012 Nov; 9(3):208-17. Tirotta E, Kirby LA, Hatch MN, Lane TE. PMID: 22885102.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    40. CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis. Future Virol. 2012 Apr; 7(4):349-359. Marro BS, Hosking MP, Lane TE. PMID: 22582084; PMCID: PMC3348576.
      View in: PubMed   Mentions: 3  
    41. Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination. Exp Neurol. 2012 May; 235(1):380-7. Whitman LM, Blanc CA, Schaumburg CS, Rowitch DH, Lane TE. PMID: 22449475; PMCID: PMC3350784.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    42. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe. 2012 Mar 15; 11(3):227-39. Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. PMID: 22423963; PMCID: PMC3308348.
      View in: PubMed   Mentions: 199     Fields:    Translation:AnimalsCells
    43. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15312-7. Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM. PMID: 21876153; PMCID: PMC3174674.
      View in: PubMed   Mentions: 71     Fields:    Translation:AnimalsCells
    44. CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination. Glia. 2011 Dec; 59(12):1813-21. Carbajal KS, Miranda JL, Tsukamoto MR, Lane TE. PMID: 21830237; PMCID: PMC5025299.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    45. Surgical transplantation of mouse neural stem cells into the spinal cords of mice infected with neurotropic mouse hepatitis virus. J Vis Exp. 2011 Jul 10; (53):e2834. Carbajal KS, Weinger JG, Whitman LM, Schaumburg CS, Lane TE. PMID: 21775959; PMCID: PMC3196172.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    46. Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation. J Immunol. 2011 Aug 01; 187(3):1358-68. Sullivan NL, Eickhoff CS, Zhang X, Giddings OK, Lane TE, Hoft DF. PMID: 21715689; PMCID: PMC3150841.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    47. CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis. Glia. 2011 Oct; 59(10):1518-28. Tirotta E, Ransohoff RM, Lane TE. PMID: 21656856; PMCID: PMC5029281.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    48. Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection. Exp Neurol. 2010 Nov; 226(1):242-53. Held KS, Steward O, Blanc C, Lane TE. PMID: 20832407; PMCID: PMC5029284.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    49. The role of chemokines during viral infection of the CNS. PLoS Pathog. 2010 Jul 29; 6(7):e1000937. Hosking MP, Lane TE. PMID: 20686655; PMCID: PMC2912390.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    50. Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice. J Neurosci. 2010 Jul 28; 30(30):10086-95. Dénes A, Humphreys N, Lane TE, Grencis R, Rothwell N. PMID: 20668193; PMCID: PMC3044869.
      View in: PubMed   Mentions: 65     Fields:    Translation:AnimalsCells
    51. Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells. J Neurosci. 2010 Jul 07; 30(27):9074-83. Liu L, Darnall L, Hu T, Choi K, Lane TE, Ransohoff RM. PMID: 20610741; PMCID: PMC2917803.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    52. CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination. PLoS One. 2010 Jun 28; 5(6):e11340. Hosking MP, Tirotta E, Ransohoff RM, Lane TE. PMID: 20596532; PMCID: PMC2893165.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    53. Cell replacement therapies to promote remyelination in a viral model of demyelination. J Neuroimmunol. 2010 Jul 27; 224(1-2):101-7. Tirotta E, Carbajal KS, Schaumburg CS, Whitman L, Lane TE. PMID: 20627412; PMCID: PMC2919340.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    54. Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11068-73. Carbajal KS, Schaumburg C, Strieter R, Kane J, Lane TE. PMID: 20534452; PMCID: PMC2890772.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    55. CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis. Nat Neurosci. 2010 Mar; 13(3):319-26. Liu L, Belkadi A, Darnall L, Hu T, Drescher C, Cotleur AC, Padovani-Claudio D, He T, Choi K, Lane TE, Miller RH, Ransohoff RM. PMID: 20154684; PMCID: PMC2827651.
      View in: PubMed   Mentions: 113     Fields:    Translation:AnimalsCells
    56. The pathogenesis of murine coronavirus infection of the central nervous system. Crit Rev Immunol. 2010; 30(2):119-30. Lane TE, Hosking MP. PMID: 20370625; PMCID: PMC2852265.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    57. A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS Pathog. 2009 Nov; 5(11):e1000648. Hosking MP, Liu L, Ransohoff RM, Lane TE. PMID: 19893623; PMCID: PMC2766051.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    58. CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination. Autoimmunity. 2009 Sep; 42(6):484-91. Stiles LN, Liu MT, Kane JA, Lane TE. PMID: 19626487; PMCID: PMC2779158.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    59. Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis. J Neuroimmunol. 2009 Jul 25; 212(1-2):74-81. Hatch MN, Schaumburg CS, Lane TE, Keirstead HS. PMID: 19477025.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    60. The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System. Curr Immunol Rev. 2009 May 04; 5(4):267-276. Hosking MP, Lane TE. PMID: 19946572; PMCID: PMC2782875.
      View in: PubMed   Mentions: 12  
    61. IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells. Virology. 2009 Feb 05; 384(1):209-15. Whitman L, Zhou H, Perlman S, Lane TE. PMID: 19059617; PMCID: PMC2779567.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    62. Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis. Virology. 2008 Dec 20; 382(2):132-44. Muse M, Kane JA, Carr DJ, Farber JM, Lane TE. PMID: 18973912; PMCID: PMC2643215.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    63. Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12/23 signaling. Viral Immunol. 2008 Jun; 21(2):173-88. Held KS, Glass WG, Orlovsky YI, Shamberger KA, Petley TD, Branigan PJ, Carton JM, Beck HS, Cunningham MR, Benson JM, Lane TE. PMID: 18570589; PMCID: PMC2570712.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    64. Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair. Front Biosci. 2008 May 01; 13:4393-406. Schaumburg CS, Held KS, Lane TE. PMID: 18508518; PMCID: PMC5025298.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    65. The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J Exp Med. 2008 Apr 14; 205(4):811-23. Carlson T, Kroenke M, Rao P, Lane TE, Segal B. PMID: 18347102; PMCID: PMC2292221.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    66. NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. J Virol. 2008 Mar; 82(6):3031-44. Walsh KB, Lanier LL, Lane TE. PMID: 18160433; PMCID: PMC2259000.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    67. Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. J Virol. 2008 Mar; 82(6):3021-30. Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE. PMID: 18094157; PMCID: PMC2259007.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    68. CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system. Viral Immunol. 2007 Dec; 20(4):599-608. Hickey MJ, Held KS, Baum E, Gao JL, Murphy PM, Lane TE. PMID: 18158733.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    69. DRAK2 regulates memory T cell responses following murine coronavirus infection. Autoimmunity. 2007 Nov; 40(7):483-8. Schaumburg CS, Gatzka M, Walsh CM, Lane TE. PMID: 17966037.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    70. Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice. Regen Med. 2007 Sep; 2(5):771-83. Gonzalez R, Hickey MJ, Espinosa JM, Nistor G, Lane TE, Keirstead HS. PMID: 17907930.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    71. Expression of CXC chemokine ligand 10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver disease. J Immunol. 2007 Jul 15; 179(2):1155-65. Walsh KB, Edwards RA, Romero KM, Kotlajich MV, Stohlman SA, Lane TE. PMID: 17617609.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    72. T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 2007 Apr 01; 109(7):2894-902. Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA. PMID: 17164340; PMCID: PMC1852227.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    73. Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system. Autoimmunity. 2007 Feb; 40(1):54-65. Ramos SJ, Hardison JL, Stiles LN, Lane TE, Walsh CM. PMID: 17364498.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    74. T cell antiviral effector function is not dependent on CXCL10 following murine coronavirus infection. J Immunol. 2006 Dec 15; 177(12):8372-80. Stiles LN, Hardison JL, Schaumburg CS, Whitman LM, Lane TE. PMID: 17142734.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    75. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16882-7. Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. PMID: 17071741; PMCID: PMC1636548.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    76. Chemokine CC receptor 2 is important for acute control of cardiac parasitism but does not contribute to cardiac inflammation after infection with Trypanosoma cruzi. J Infect Dis. 2006 Jun 01; 193(11):1584-8. Hardison JL, Kuziel WA, Manning JE, Lane TE. PMID: 16652288; PMCID: PMC7109801.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    77. Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. J Gen Virol. 2006 Mar; 87(Pt 3):489-499. Carr DJJ, Ash J, Lane TE, Kuziel WA. PMID: 16476970; PMCID: PMC1479868.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    78. Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS. Eur J Immunol. 2006 Mar; 36(3):613-22. Stiles LN, Hosking MP, Edwards RA, Strieter RM, Lane TE. PMID: 16479546.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    79. Coronavirus infection of the central nervous system: host-virus stand-off. Nat Rev Microbiol. 2006 Feb; 4(2):121-32. Bergmann CC, Lane TE, Stohlman SA. PMID: 16415928; PMCID: PMC7096820.
      View in: PubMed   Mentions: 248     Fields:    Translation:AnimalsCells
    80. Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. Curr Top Microbiol Immunol. 2006; 303:1-27. Lane TE, Hardison JL, Walsh KB. PMID: 16570854; PMCID: PMC7121733.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    81. The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006 Jan; 74(1):135-43. Hardison JL, Wrightsman RA, Carpenter PM, Kuziel WA, Lane TE, Manning JE. PMID: 16368966; PMCID: PMC1346647.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    82. The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006 Jan; 74(1):125-34. Hardison JL, Wrightsman RA, Carpenter PM, Lane TE, Manning JE. PMID: 16368965; PMCID: PMC1346648.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    83. NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system. Adv Exp Med Biol. 2006; 581:369-72. Walsh KB, Lodoen MB, Lanier LL, Lane TE. PMID: 17037561; PMCID: PMC7123950.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    84. Transplantation of glial-committed progenitor cells into a viral model of multiple sclerosis induces remyelination in the absence of an attenuated inflammatory response. Exp Neurol. 2006 Feb; 197(2):420-9. Hardison JL, Nistor G, Gonzalez R, Keirstead HS, Lane TE. PMID: 16297915; PMCID: PMC7094399.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    85. Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection. Int Immunol. 2005 May; 17(5):569-79. Ure DR, Lane TE, Liu MT, Rodriguez M. PMID: 15824069; PMCID: PMC7108597.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    86. Differential roles of CCL2 and CCR2 in host defense to coronavirus infection. Virology. 2004 Nov 24; 329(2):251-60. Held KS, Chen BP, Kuziel WA, Rollins BJ, Lane TE. PMID: 15518805; PMCID: PMC7111831.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    87. The CC chemokine ligand 3 regulates CD11c+CD11b+CD8alpha- dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation. Virology. 2004 Sep 15; 327(1):8-15. Trifilo MJ, Lane TE. PMID: 15327893; PMCID: PMC7111789.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    88. Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis. Exp Neurol. 2004 Jun; 187(2):254-65. Totoiu MO, Nistor GI, Lane TE, Keirstead HS. PMID: 15144852; PMCID: PMC7125733.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    89. Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol. 2004 Jun 01; 172(11):6615-25. Deane JA, Trifilo MJ, Yballe CM, Choi S, Lane TE, Fruman DA. PMID: 15153476.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    90. Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol. 2004 Apr 01; 172(7):4018-25. Glass WG, Hickey MJ, Hardison JL, Liu MT, Manning JE, Lane TE. PMID: 15034013.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    91. Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult Scler. 2004 Feb; 10(1):26-34. Tsunoda I, Lane TE, Blackett J, Fujinami RS. PMID: 14760949.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    92. CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. J Virol. 2004 Jan; 78(2):585-94. Trifilo MJ, Montalto-Morrison C, Stiles LN, Hurst KR, Hardison JL, Manning JE, Masters PS, Lane TE. PMID: 14694090; PMCID: PMC368822.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    93. Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury. Exp Neurol. 2003 Nov; 184(1):456-63. Gonzalez R, Glaser J, Liu MT, Lane TE, Keirstead HS. PMID: 14637115.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    94. Measles virus infection induces chemokine synthesis by neurons. J Immunol. 2003 Sep 15; 171(6):3102-9. Patterson CE, Daley JK, Echols LA, Lane TE, Rall GF. PMID: 12960336.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    95. Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection. J Virol. 2003 Sep; 77(18):10037-46. Carr DJ, Chodosh J, Ash J, Lane TE. PMID: 12941914; PMCID: PMC224594.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    96. Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8+ T cells following coronavirus infection of the central nervous system. Virology. 2003 Aug 01; 312(2):407-14. Glass WG, Lane TE. PMID: 12919745; PMCID: PMC7127441.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    97. Adenovirus-mediated expression of CXCL10 in the central nervous system results in T-cell recruitment and limited neuropathology. J Neurovirol. 2003 Jun; 9(3):315-24. Trifilo MJ, Lane TE. PMID: 12775415; PMCID: PMC7095127.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    98. CC chemokine ligand 3 (CCL3) regulates CD8(+)-T-cell effector function and migration following viral infection. J Virol. 2003 Apr; 77(7):4004-14. Trifilo MJ, Bergmann CC, Kuziel WA, Lane TE. PMID: 12634360; PMCID: PMC150617.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    99. Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease. J Virol. 2003 Jan; 77(1):191-8. Glass WG, Lane TE. PMID: 12477824; PMCID: PMC140629.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    100. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002 Apr 01; 168(7):3195-204. Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, Luster AD. PMID: 11907072.
      View in: PubMed   Mentions: 472     Fields:    Translation:AnimalsCells
    101. Mouse hepatitis virus infection of the central nervous system: chemokine-mediated regulation of host defense and disease. Viral Immunol. 2002; 15(2):261-72. Glass WG, Chen BP, Liu MT, Lane TE. PMID: 12081011.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    102. A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination. J Virol. 2000 Feb; 74(3):1415-24. Lane TE, Liu MT, Chen BP, Asensio VC, Samawi RM, Paoletti AD, Campbell IL, Kunkel SL, Fox HS, Buchmeier MJ. PMID: 10627552; PMCID: PMC111476.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    103. Inhibition of nitric oxide synthase-2 reduces the severity of mouse hepatitis virus-induced demyelination: implications for NOS2/NO regulation of chemokine expression and inflammation. J Neurovirol. 1999 Feb; 5(1):48-54. Lane TE, Fox HS, Buchmeier MJ. PMID: 10190690.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    With one click, see people who:

    Run Clinical Trials

    See more options in the Advanced Search tab

    Thomas's Networks
    Concepts (386)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (19)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    UCI Profiles is managed by the UCSF Clinical and Translational Science Institute (CTSI), part of the Clinical and Translational Science Award program funded by the National Center for Advancing Translational Sciences (Grant Number UL1 TR000004) at the National Institutes of Health (NIH).
    This site is running Profiles RNS version UCSF-v3.1.0-3-g1ef1264b on PROFILES-PWEB04. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.

    Copyright © The Regents of the University of California