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Thomas Edward Lane

Title(s)Professor, Neurobiology & Behavior
Phone(949) 824-1360
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    Collapse Research 
    Collapse Research Activities and Funding
    Chemokines and Viral-Induced Neurologic Disease
    NIH/NINDS R01NS041249Jan 28, 2020 - Nov 30, 2015
    Role: Principal Investigator
    Human neural precursor cell-mediated therapy in a viral model of demyelination
    NIH/NINDS R01NS092042Jan 1, 2020 - Mar 31, 2020
    Role: Principal Investigator
    Viral-induced axonopathy: mechanisms of damage and repair
    NIH/NINDS R01NS091939Apr 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Viral-induced demyelination and neural stem cell-mediated remyelination
    NIH/NINDS R01NS074987Jul 1, 2011 - Jun 30, 2016
    Role: Principal Investigator
    PATHOLOGICAL MECHANISMS OF DEMYELINATION
    NIH/NINDS R29NS037336Feb 1, 1998 - Jan 31, 2003
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ramstead AG, Wallace JA, Lee SH, Bauer KM, Tang WW, Ekiz HA, Lane TE, Cluntun AA, Bettini ML, Round JL, Rutter J, O'Connell RM. Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development. Cell Rep. 2020 Mar 03; 30(9):2889-2899.e6. PMID: 32130894.
      View in: PubMed
    2. Darling TK, Mimche PN, Bray C, Umaru B, Brady LM, Stone C, Eboumbou Moukoko CE, Lane TE, Ayong LS, Lamb TJ. EphA2 contributes to disruption of the blood-brain barrier in cerebral malaria. PLoS Pathog. 2020 Jan; 16(1):e1008261. PMID: 31999807.
      View in: PubMed
    3. Skinner DD, Lane TE. CXCR2 Signaling and Remyelination in Preclinical Models of Demyelination. DNA Cell Biol. 2020 Jan; 39(1):3-7. PMID: 31851535.
      View in: PubMed
    4. Marro BS, Skinner DD, Cheng Y, Grist JJ, Dickey LL, Eckman E, Stone C, Liu L, Ransohoff RM, Lane TE. Disrupted CXCR2 Signaling in Oligodendroglia Lineage Cells Enhances Myelin Repair in a Viral Model of Multiple Sclerosis. J Virol. 2019 Sep 15; 93(18). PMID: 31243125.
      View in: PubMed
    5. Brown DG, Soto R, Yandamuri S, Stone C, Dickey L, Gomes-Neto JC, Pastuzyn ED, Bell R, Petersen C, Buhrke K, Fujinami RS, O'Connell RM, Stephens WZ, Shepherd JD, Lane TE, Round JL. The microbiota protects from viral-induced neurologic damage through microglia-intrinsic TLR signaling. Elife. 2019 07 16; 8. PMID: 31309928.
      View in: PubMed
    6. Kim H, Dickey L, Stone C, Jafek JL, Lane TE, Tantin D. T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response. J Neuroinflammation. 2019 Jul 03; 16(1):133. PMID: 31266507.
      View in: PubMed
    7. Anantpadma M, Lane T, Zorn KM, Lingerfelt MA, Clark AM, Freundlich JS, Davey RA, Madrid PB, Ekins S. Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads. ACS Omega. 2019 Jan 31; 4(1):2353-2361. PMID: 30729228.
      View in: PubMed
    8. Cheng Y, Skinner DD, Lane TE. Innate Immune Responses and Viral-Induced Neurologic Disease. J Clin Med. 2018 Dec 20; 8(1). PMID: 30577473.
      View in: PubMed
    9. Mollaoglu G, Jones A, Wait SJ, Mukhopadhyay A, Jeong S, Arya R, Camolotto SA, Mosbruger TL, Stubben CJ, Conley CJ, Bhutkar A, Vahrenkamp JM, Berrett KC, Cessna MH, Lane TE, Witt BL, Salama ME, Gertz J, Jones KB, Snyder EL, Oliver TG. The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment. Immunity. 2018 10 16; 49(4):764-779.e9. PMID: 30332632.
      View in: PubMed
    10. Mangale V, McIntyre LL, Walsh CM, Loring JF, Lane TE. Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease. Dev Dyn. 2019 01; 248(1):43-52. PMID: 30067309.
      View in: PubMed
    11. Skinner D, Marro BS, Lane TE. Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease. Viral Immunol. 2019 Jan/Feb; 32(1):25-37. PMID: 30109979.
      View in: PubMed
    12. Grist JJ, Marro BS, Skinner DD, Syage AR, Worne C, Doty DJ, Fujinami RS, Lane TE. Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment. Eur J Immunol. 2018 07; 48(7):1199-1210. PMID: 29697856.
      View in: PubMed
    13. Denham ST, Verma S, Reynolds RC, Worne CL, Daugherty JM, Lane TE, Brown JCS. Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System. Infect Immun. 2018 03; 86(3). PMID: 29203547.
      View in: PubMed
    14. Mangale V, Marro BS, Plaisted WC, Walsh CM, Lane TE. Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus. Virology. 2017 11; 511:49-55. PMID: 28822268.
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    15. Lane TE. Preface. J Neuroimmunol. 2017 07 15; 308:1. PMID: 28623960.
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    16. Soto R, Petersen C, Novis CL, Kubinak JL, Bell R, Stephens WZ, Lane TE, Fujinami RS, Bosque A, O'Connell RM, Round JL. Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):5497-5502. PMID: 28487480.
      View in: PubMed
    17. Bobik K, McCray TN, Ernest B, Fernandez JC, Howell KA, Lane T, Staton M, Burch-Smith TM. The chloroplast RNA helicase ISE2 is required for multiple chloroplast RNA processing steps in Arabidopsis thaliana. Plant J. 2017 Jul; 91(1):114-131. PMID: 28346704.
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    18. Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, Harris TH, Cross AH. Speaking out about gender imbalance in invited speakers improves diversity. Nat Immunol. 2017 04 18; 18(5):475-478. PMID: 28418385.
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    19. Dickey LL, Hanley TM, Huffaker TB, Ramstead AG, O'Connell RM, Lane TE. MicroRNA 155 and viral-induced neuroinflammation. J Neuroimmunol. 2017 07 15; 308:17-24. PMID: 28139244.
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    20. Dickey LL, Worne CL, Glover JL, Lane TE, O'Connell RM. MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease. J Neuroinflammation. 2016 09 07; 13(1):240. PMID: 27604627.
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    21. Plaisted WC, Zavala A, Hingco E, Tran H, Coleman R, Lane TE, Loring JF, Walsh CM. Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis. PLoS One. 2016; 11(6):e0157620. PMID: 27310015.
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    22. Grist JJ, Marro B, Lane TE. Neutrophils and viral-induced neurologic disease. Clin Immunol. 2018 04; 189:52-56. PMID: 27288312.
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    23. Yandamuri SS, Lane TE. Imaging Axonal Degeneration and Repair in Preclinical Animal Models of Multiple Sclerosis. Front Immunol. 2016; 7:189. PMID: 27242796.
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    24. Marsh SE, Abud EM, Lakatos A, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):E1316-25. PMID: 26884167.
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    25. Marro BS, Grist JJ, Lane TE. Inducible Expression of CXCL1 within the Central Nervous System Amplifies Viral-Induced Demyelination. J Immunol. 2016 Feb 15; 196(4):1855-64. PMID: 26773148.
      View in: PubMed
    26. Blanc CA, Grist JJ, Rosen H, Sears-Kraxberger I, Steward O, Lane TE. Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination. Am J Pathol. 2015 Oct; 185(10):2819-32. PMID: 26435414.
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    27. Herz J, Sabellek P, Lane TE, Gunzer M, Hermann DM, Doeppner TR. Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice. Stroke. 2015 Oct; 46(10):2916-25. PMID: 26337969.
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    28. Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh CM, Lane TE, Cahalan MD. Two-photon imaging of cellular dynamics in the mouse spinal cord. J Vis Exp. 2015 Feb 22; (96). PMID: 25742043.
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    29. Weinger JG, Plaisted WC, Maciejewski SM, Lanier LL, Walsh CM, Lane TE. Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis. Stem Cells. 2014 Oct; 32(10):2690-701. PMID: 24898518.
      View in: PubMed
    30. Marro BS, Blanc CA, Loring JF, Cahalan MD, Lane TE. Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies. Expert Rev Neurother. 2014 Oct; 14(10):1169-79. PMID: 25245576.
      View in: PubMed
    31. Peng Y, Lai Z, Lane T, Nageswara-Rao M, Okada M, Jasieniuk M, O'Geen H, Kim RW, Sammons RD, Rieseberg LH, Stewart CN. De novo genome assembly of the economically important weed horseweed using integrated data from multiple sequencing platforms. Plant Physiol. 2014 Nov; 166(3):1241-54. PMID: 25209985.
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    32. Blanc CA, Rosen H, Lane TE. FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. J Neuroinflammation. 2014 Aug 20; 11:138. PMID: 25138356.
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    33. Libbey JE, Lane TE, Fujinami RS. Axonal pathology and demyelination in viral models of multiple sclerosis. Discov Med. 2014 Jul-Aug; 18(97):79-89. PMID: 25091490.
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    34. Hosking MP, Lane TE. ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease. Front Cell Neurosci. 2014; 8:165. PMID: 24987333.
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    35. Greenberg ML, Weinger JG, Matheu MP, Carbajal KS, Parker I, Macklin WB, Lane TE, Cahalan MD. Two-photon imaging of remyelination of spinal cord axons by engrafted neural precursor cells in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2349-55. PMID: 24843159.
      View in: PubMed
    36. Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 03; 2(6):825-37. PMID: 24936469.
      View in: PubMed
    37. Chucair-Elliott AJ, Conrady C, Zheng M, Kroll CM, Lane TE, Carr DJ. Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells. Glia. 2014 Sep; 62(9):1418-34. PMID: 24807365.
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    38. Held KS, Lane TE. Spinal cord injury, immunodepression, and antigenic challenge. Semin Immunol. 2014 Oct; 26(5):415-20. PMID: 24747011.
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    39. Cunard R, Marquez II, Ball ED, Nelson CL, Corringham S, Clopton P, Sanchez AP, Lane T, Ward DM. Prophylactic red blood cell exchange for ABO-mismatched hematopoietic progenitor cell transplants. Transfusion. 2014 Jul; 54(7):1857-63. PMID: 24372185.
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    40. Plaisted WC, Weinger JG, Walsh CM, Lane TE. T cell mediated suppression of neurotropic coronavirus replication in neural precursor cells. Virology. 2014 Jan 20; 449:235-43. PMID: 24418558.
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    41. Villegas-Mendez A, Gwyer Findlay E, de Souza JB, Grady LM, Saris CJ, Lane TE, Riley EM, Couper KN. WSX-1 signalling inhibits CD4? T cell migration to the liver during malaria infection by repressing chemokine-independent pathways. PLoS One. 2013; 8(11):e78486. PMID: 24244314.
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    42. Weinger JG, Chen L, Coleman R, Leang R, Plaisted WC, Loring JF, Lane TE. Intraspinal transplantation of mouse and human neural precursor cells. Curr Protoc Stem Cell Biol. 2013 Sep 20; 26:2D.16.1-2D.16.16. PMID: 24510791.
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    43. Weinger JG, Marro BS, Hosking MP, Lane TE. The chemokine receptor CXCR2 and coronavirus-induced neurologic disease. Virology. 2013 Jan 05; 435(1):110-7. PMID: 23217621.
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    44. Nance JP, Vannella KM, Worth D, David C, Carter D, Noor S, Hubeau C, Fitz L, Lane TE, Wynn TA, Wilson EH. Chitinase dependent control of protozoan cyst burden in the brain. PLoS Pathog. 2012; 8(11):e1002990. PMID: 23209401.
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    45. Weinger JG, Weist BM, Plaisted WC, Klaus SM, Walsh CM, Lane TE. MHC mismatch results in neural progenitor cell rejection following spinal cord transplantation in a model of viral-induced demyelination. Stem Cells. 2012 Nov; 30(11):2584-95. PMID: 22969049.
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    46. Tirotta E, Duncker P, Oak J, Klaus S, Tsukamoto MR, Gov L, Lane TE. Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis. J Neuroimmunol. 2013 Jan 15; 254(1-2):110-6. PMID: 23102608.
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    47. Zhao J, Wohlford-Lenane C, Zhao J, Fleming E, Lane TE, McCray PB, Perlman S. Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections. J Virol. 2012 Nov; 86(21):11416-24. PMID: 22915814.
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    48. Tirotta E, Kirby LA, Hatch MN, Lane TE. IFN-?-induced apoptosis of human embryonic stem cell derived oligodendrocyte progenitor cells is restricted by CXCR2 signaling. Stem Cell Res. 2012 Nov; 9(3):208-17. PMID: 22885102.
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    49. Oropallo MA, Held KS, Goenka R, Ahmad SA, O'Neill PJ, Steward O, Lane TE, Cancro MP. Chronic spinal cord injury impairs primary antibody responses but spares existing humoral immunity in mice. J Immunol. 2012 Jun 01; 188(11):5257-66. PMID: 22523388.
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    50. Marro BS, Hosking MP, Lane TE. CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis. Future Virol. 2012 Apr; 7(4):349-359. PMID: 22582084.
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    51. Whitman LM, Blanc CA, Schaumburg CS, Rowitch DH, Lane TE. Olig1 function is required for remyelination potential of transplanted neural progenitor cells in a model of viral-induced demyelination. Exp Neurol. 2012 May; 235(1):380-7. PMID: 22449475.
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    52. Liu JZ, Jellbauer S, Poe AJ, Ton V, Pesciaroli M, Kehl-Fie TE, Restrepo NA, Hosking MP, Edwards RA, Battistoni A, Pasquali P, Lane TE, Chazin WJ, Vogl T, Roth J, Skaar EP, Raffatellu M. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe. 2012 Mar 15; 11(3):227-39. PMID: 22423963.
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    53. Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15312-7. PMID: 21876153.
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    54. Carbajal KS, Miranda JL, Tsukamoto MR, Lane TE. CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination. Glia. 2011 Dec; 59(12):1813-21. PMID: 21830237.
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    55. Carbajal KS, Weinger JG, Whitman LM, Schaumburg CS, Lane TE. Surgical transplantation of mouse neural stem cells into the spinal cords of mice infected with neurotropic mouse hepatitis virus. J Vis Exp. 2011 Jul 10; (53):e2834. PMID: 21775959.
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    56. Sullivan NL, Eickhoff CS, Zhang X, Giddings OK, Lane TE, Hoft DF. Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation. J Immunol. 2011 Aug 01; 187(3):1358-68. PMID: 21715689.
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    57. Tirotta E, Ransohoff RM, Lane TE. CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-?/CXCL10-mediated apoptosis. Glia. 2011 Oct; 59(10):1518-28. PMID: 21656856.
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    58. Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM. Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol. 2011 Jun; 178(6):2811-22. PMID: 21531375.
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    59. Köhler A, De Filippo K, Hasenberg M, van den Brandt C, Nye E, Hosking MP, Lane TE, Männ L, Ransohoff RM, Hauser AE, Winter O, Schraven B, Geiger H, Hogg N, Gunzer M. G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands. Blood. 2011 Apr 21; 117(16):4349-57. PMID: 21224471.
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    60. Held KS, Steward O, Blanc C, Lane TE. Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection. Exp Neurol. 2010 Nov; 226(1):242-53. PMID: 20832407.
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    61. Hosking MP, Lane TE. The role of chemokines during viral infection of the CNS. PLoS Pathog. 2010 Jul 29; 6(7):e1000937. PMID: 20686655.
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    62. Dénes A, Humphreys N, Lane TE, Grencis R, Rothwell N. Chronic systemic infection exacerbates ischemic brain damage via a CCL5 (regulated on activation, normal T-cell expressed and secreted)-mediated proinflammatory response in mice. J Neurosci. 2010 Jul 28; 30(30):10086-95. PMID: 20668193.
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    63. Liu L, Darnall L, Hu T, Choi K, Lane TE, Ransohoff RM. Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells. J Neurosci. 2010 Jul 07; 30(27):9074-83. PMID: 20610741.
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    64. Hosking MP, Tirotta E, Ransohoff RM, Lane TE. CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination. PLoS One. 2010 Jun 28; 5(6):e11340. PMID: 20596532.
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    65. Tirotta E, Carbajal KS, Schaumburg CS, Whitman L, Lane TE. Cell replacement therapies to promote remyelination in a viral model of demyelination. J Neuroimmunol. 2010 Jul 27; 224(1-2):101-7. PMID: 20627412.
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    66. Carbajal KS, Schaumburg C, Strieter R, Kane J, Lane TE. Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11068-73. PMID: 20534452.
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    67. Liu L, Belkadi A, Darnall L, Hu T, Drescher C, Cotleur AC, Padovani-Claudio D, He T, Choi K, Lane TE, Miller RH, Ransohoff RM. CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis. Nat Neurosci. 2010 Mar; 13(3):319-26. PMID: 20154684.
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    68. Lane TE, Hosking MP. The pathogenesis of murine coronavirus infection of the central nervous system. Crit Rev Immunol. 2010; 30(2):119-30. PMID: 20370625.
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    69. Hosking MP, Liu L, Ransohoff RM, Lane TE. A protective role for ELR+ chemokines during acute viral encephalomyelitis. PLoS Pathog. 2009 Nov; 5(11):e1000648. PMID: 19893623.
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    70. Stiles LN, Liu MT, Kane JA, Lane TE. CXCL10 and trafficking of virus-specific T cells during coronavirus-induced demyelination. Autoimmunity. 2009 Sep; 42(6):484-91. PMID: 19626487.
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    71. Drennan MB, Franki AS, Dewint P, Van Beneden K, Seeuws S, van de Pavert SA, Reilly EC, Verbruggen G, Lane TE, Mebius RE, Deforce D, Elewaut D. Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymus. J Immunol. 2009 Aug 15; 183(4):2213-6. PMID: 19620294.
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    72. Hatch MN, Schaumburg CS, Lane TE, Keirstead HS. Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis. J Neuroimmunol. 2009 Jul 25; 212(1-2):74-81. PMID: 19477025.
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    73. Hosking MP, Lane TE. The Biology of Persistent Infection: Inflammation and Demyelination following Murine Coronavirus Infection of the Central Nervous System. Curr Immunol Rev. 2009 May 04; 5(4):267-276. PMID: 19946572.
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    74. Whitman L, Zhou H, Perlman S, Lane TE. IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells. Virology. 2009 Feb 05; 384(1):209-15. PMID: 19059617.
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    75. Muse M, Kane JA, Carr DJ, Farber JM, Lane TE. Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis. Virology. 2008 Dec 20; 382(2):132-44. PMID: 18973912.
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    76. Lindell DM, Lane TE, Lukacs NW. CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Eur J Immunol. 2008 Aug; 38(8):2168-79. PMID: 18624292.
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    77. Held KS, Glass WG, Orlovsky YI, Shamberger KA, Petley TD, Branigan PJ, Carton JM, Beck HS, Cunningham MR, Benson JM, Lane TE. Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12/23 signaling. Viral Immunol. 2008 Jun; 21(2):173-88. PMID: 18570589.
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    78. Schaumburg CS, Held KS, Lane TE. Mouse hepatitis virus infection of the CNS: a model for defense, disease, and repair. Front Biosci. 2008 May 01; 13:4393-406. PMID: 18508518.
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    79. Carlson T, Kroenke M, Rao P, Lane TE, Segal B. The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease. J Exp Med. 2008 Apr 14; 205(4):811-23. PMID: 18347102.
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    80. Walsh KB, Lanier LL, Lane TE. NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis. J Virol. 2008 Mar; 82(6):3031-44. PMID: 18160433.
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    81. Walsh KB, Lodoen MB, Edwards RA, Lanier LL, Lane TE. Evidence for differential roles for NKG2D receptor signaling in innate host defense against coronavirus-induced neurological and liver disease. J Virol. 2008 Mar; 82(6):3021-30. PMID: 18094157.
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    82. Hickey MJ, Held KS, Baum E, Gao JL, Murphy PM, Lane TE. CCR1 deficiency increases susceptibility to fatal coronavirus infection of the central nervous system. Viral Immunol. 2007 Dec; 20(4):599-608. PMID: 18158733.
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    83. Schaumburg CS, Gatzka M, Walsh CM, Lane TE. DRAK2 regulates memory T cell responses following murine coronavirus infection. Autoimmunity. 2007 Nov; 40(7):483-8. PMID: 17966037.
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    84. Gonzalez R, Hickey MJ, Espinosa JM, Nistor G, Lane TE, Keirstead HS. Therapeutic neutralization of CXCL10 decreases secondary degeneration and functional deficit after spinal cord injury in mice. Regen Med. 2007 Sep; 2(5):771-83. PMID: 17907930.
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    85. Walsh KB, Edwards RA, Romero KM, Kotlajich MV, Stohlman SA, Lane TE. Expression of CXC chemokine ligand 10 from the mouse hepatitis virus genome results in protection from viral-induced neurological and liver disease. J Immunol. 2007 Jul 15; 179(2):1155-65. PMID: 17617609.
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    86. Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA. T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 2007 Apr 01; 109(7):2894-902. PMID: 17164340.
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    87. Ramos SJ, Hardison JL, Stiles LN, Lane TE, Walsh CM. Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system. Autoimmunity. 2007 Feb; 40(1):54-65. PMID: 17364498.
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    88. Stiles LN, Hardison JL, Schaumburg CS, Whitman LM, Lane TE. T cell antiviral effector function is not dependent on CXCL10 following murine coronavirus infection. J Immunol. 2006 Dec 15; 177(12):8372-80. PMID: 17142734.
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    89. Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16882-7. PMID: 17071741.
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    90. Chen JP, Lu HL, Lai SL, Campanella GS, Sung JM, Lu MY, Wu-Hsieh BA, Lin YL, Lane TE, Luster AD, Liao F. Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. J Immunol. 2006 Sep 01; 177(5):3185-92. PMID: 16920957.
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    91. Hardison JL, Kuziel WA, Manning JE, Lane TE. Chemokine CC receptor 2 is important for acute control of cardiac parasitism but does not contribute to cardiac inflammation after infection with Trypanosoma cruzi. J Infect Dis. 2006 Jun 01; 193(11):1584-8. PMID: 16652288.
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    92. Carr DJ, Ash J, Lane TE, Kuziel WA. Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. J Gen Virol. 2006 Mar; 87(Pt 3):489-99. PMID: 16476970.
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    93. Stiles LN, Hosking MP, Edwards RA, Strieter RM, Lane TE. Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS. Eur J Immunol. 2006 Mar; 36(3):613-22. PMID: 16479546.
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    94. Bergmann CC, Lane TE, Stohlman SA. Coronavirus infection of the central nervous system: host-virus stand-off. Nat Rev Microbiol. 2006 Feb; 4(2):121-32. PMID: 16415928.
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    95. Lane TE, Hardison JL, Walsh KB. Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system. Curr Top Microbiol Immunol. 2006; 303:1-27. PMID: 16570854.
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    96. Hardison JL, Wrightsman RA, Carpenter PM, Lane TE, Manning JE. The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006 Jan; 74(1):125-34. PMID: 16368965.
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    97. Hardison JL, Wrightsman RA, Carpenter PM, Kuziel WA, Lane TE, Manning JE. The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun. 2006 Jan; 74(1):135-43. PMID: 16368966.
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    98. Walsh KB, Lodoen MB, Lanier LL, Lane TE. NKG2D signaling and host defense after mouse hepatitis virus infection of the central nervous system. Adv Exp Med Biol. 2006; 581:369-72. PMID: 17037561.
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    99. Hardison JL, Nistor G, Gonzalez R, Keirstead HS, Lane TE. Transplantation of glial-committed progenitor cells into a viral model of multiple sclerosis induces remyelination in the absence of an attenuated inflammatory response. Exp Neurol. 2006 Feb; 197(2):420-9. PMID: 16297915.
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    100. Cliffe LJ, Humphreys NE, Lane TE, Potten CS, Booth C, Grencis RK. Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion. Science. 2005 Jun 03; 308(5727):1463-5. PMID: 15933199.
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    101. Ure DR, Lane TE, Liu MT, Rodriguez M. Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection. Int Immunol. 2005 May; 17(5):569-79. PMID: 15824069.
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    102. Held KS, Chen BP, Kuziel WA, Rollins BJ, Lane TE. Differential roles of CCL2 and CCR2 in host defense to coronavirus infection. Virology. 2004 Nov 24; 329(2):251-60. PMID: 15518805.
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    103. Trifilo MJ, Lane TE. The CC chemokine ligand 3 regulates CD11c+CD11b+CD8alpha- dendritic cell maturation and activation following viral infection of the central nervous system: implications for a role in T cell activation. Virology. 2004 Sep 15; 327(1):8-15. PMID: 15327893.
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    104. Totoiu MO, Nistor GI, Lane TE, Keirstead HS. Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis. Exp Neurol. 2004 Jun; 187(2):254-65. PMID: 15144852.
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    105. Deane JA, Trifilo MJ, Yballe CM, Choi S, Lane TE, Fruman DA. Enhanced T cell proliferation in mice lacking the p85beta subunit of phosphoinositide 3-kinase. J Immunol. 2004 Jun 01; 172(11):6615-25. PMID: 15153476.
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    106. Glass WG, Hickey MJ, Hardison JL, Liu MT, Manning JE, Lane TE. Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. J Immunol. 2004 Apr 01; 172(7):4018-25. PMID: 15034013.
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    107. Tsunoda I, Lane TE, Blackett J, Fujinami RS. Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult Scler. 2004 Feb; 10(1):26-34. PMID: 14760949.
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    108. Wickham S, Ash J, Lane TE, Carr DJ. Consequences of CXCL10 and IL-6 induction by the murine IFN-alpha1 transgene in ocular herpes simplex virus type 1 infection. Immunol Res. 2004; 30(2):191-200. PMID: 15477660.
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    109. Trifilo MJ, Montalto-Morrison C, Stiles LN, Hurst KR, Hardison JL, Manning JE, Masters PS, Lane TE. CXC chemokine ligand 10 controls viral infection in the central nervous system: evidence for a role in innate immune response through recruitment and activation of natural killer cells. J Virol. 2004 Jan; 78(2):585-94. PMID: 14694090.
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    110. Gonzalez R, Glaser J, Liu MT, Lane TE, Keirstead HS. Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury. Exp Neurol. 2003 Nov; 184(1):456-63. PMID: 14637115.
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    111. Patterson CE, Daley JK, Echols LA, Lane TE, Rall GF. Measles virus infection induces chemokine synthesis by neurons. J Immunol. 2003 Sep 15; 171(6):3102-9. PMID: 12960336.
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    112. Carr DJ, Chodosh J, Ash J, Lane TE. Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection. J Virol. 2003 Sep; 77(18):10037-46. PMID: 12941914.
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    113. Glass WG, Lane TE. Functional analysis of the CC chemokine receptor 5 (CCR5) on virus-specific CD8+ T cells following coronavirus infection of the central nervous system. Virology. 2003 Aug 01; 312(2):407-14. PMID: 12919745.
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    114. Trifilo MJ, Lane TE. Adenovirus-mediated expression of CXCL10 in the central nervous system results in T-cell recruitment and limited neuropathology. J Neurovirol. 2003 Jun; 9(3):315-24. PMID: 12775415.
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    115. Trifilo MJ, Bergmann CC, Kuziel WA, Lane TE. CC chemokine ligand 3 (CCL3) regulates CD8(+)-T-cell effector function and migration following viral infection. J Virol. 2003 Apr; 77(7):4004-14. PMID: 12634360.
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    116. Glass WG, Lane TE. Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease. J Virol. 2003 Jan; 77(1):191-8. PMID: 12477824.
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    117. Arai K, Liu ZX, Lane T, Dennert G. IP-10 and Mig facilitate accumulation of T cells in the virus-infected liver. Cell Immunol. 2002 Sep; 219(1):48-56. PMID: 12473267.
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    118. Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, Luster AD. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002 Apr 01; 168(7):3195-204. PMID: 11907072.
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    119. Chen BP, Lane TE. Lack of nitric oxide synthase type 2 (NOS2) results in reduced neuronal apoptosis and mortality following mouse hepatitis virus infection of the central nervous system. J Neurovirol. 2002 Feb; 8(1):58-63. PMID: 11847593.
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    120. Glass WG, Chen BP, Liu MT, Lane TE. Mouse hepatitis virus infection of the central nervous system: chemokine-mediated regulation of host defense and disease. Viral Immunol. 2002; 15(2):261-72. PMID: 12081011.
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    121. Lane TE, Liu MT, Chen BP, Asensio VC, Samawi RM, Paoletti AD, Campbell IL, Kunkel SL, Fox HS, Buchmeier MJ. A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination. J Virol. 2000 Feb; 74(3):1415-24. PMID: 10627552.
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    122. Lane TE, Fox HS, Buchmeier MJ. Inhibition of nitric oxide synthase-2 reduces the severity of mouse hepatitis virus-induced demyelination: implications for NOS2/NO regulation of chemokine expression and inflammation. J Neurovirol. 1999 Feb; 5(1):48-54. PMID: 10190690.
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