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Walsh, Craig

TitleProfessor
InstitutionUniversity of California, Irvine
DepartmentMolecular Biology & Biochem
Address3215 McGaugh Hall
Zot 3900
CA 92697
Phone(949) 824-8487, 9343
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    Collapse Research 
    Collapse Research Activities and Funding
    Modulation of T Cell Activation and Tolerance by DRAK2
    NIH/NIAID R01AI063419Jun 1, 2005 - Nov 28, 2011
    Role: Principal Investigator
    Growth Regulation of Activated T Cells by FADD
    NIH/NIAID R01AI050606Dec 1, 2002 - Nov 30, 2008
    Role: Principal Investigator
    DEATH RECEPTOR SIGNALING PATHWAYS IN T CELL DEVELOPMENT
    NIH/NIAID F32AI010454Apr 1, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mangale V, Marro BS, Plaisted WC, Walsh C, Lane TE. Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus. Virology. 2017 11; 511:49-55. PMID: 28822268.
      View in: PubMed
    2. Lengfeld JE, Lutz SE, Smith JR, Diaconu C, Scott C, Kofman SB, Choi C, Walsh C, Raine CS, Agalliu I, Agalliu D. Endothelial Wnt/ß-catenin signaling reduces immune cell infiltration in multiple sclerosis. Proc Natl Acad Sci U S A. 2017 02 14; 114(7):E1168-E1177. PMID: 28137846.
      View in: PubMed
    3. Pai C, Walsh C, Fruman DA. Context-Specific Function of S6K2 in Th Cell Differentiation. J Immunol. 2016 10 15; 197(8):3049-3058. PMID: 27613697.
      View in: PubMed
    4. Plaisted WC, Zavala A, Hingco E, Tran H, Coleman R, Lane TE, Loring JF, Walsh C. Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis. PLoS One. 2016; 11(6):e0157620. PMID: 27310015; PMCID: PMC4911106.
    5. Liao W, Pham V, Liu L, Riazifar M, Pone EJ, Zhang SX, Ma F, Lu M, Walsh C, Zhao W. Mesenchymal stem cells engineered to express selectin ligands and IL-10 exert enhanced therapeutic efficacy in murine experimental autoimmune encephalomyelitis. Biomaterials. 2016 Jan; 77:87-97. PMID: 26584349; PMCID: PMC4684451 [Available on 01/01/17].
    6. Walsh C. Editorial: Tweaking T cell receptor signaling thresholds through DAG: the role of diacylglycerol kinase ? in T cell responses to TGF-ß. J Leukoc Biol. 2015 Nov; 98(5):685-7. PMID: 26525843.
      View in: PubMed
    7. Weinger JG, Greenberg ML, Matheu MP, Parker I, Walsh C, Lane TE, Cahalan MD. Two-photon imaging of cellular dynamics in the mouse spinal cord. J Vis Exp. 2015 Feb 22; (96). PMID: 25742043; PMCID: PMC4354666.
    8. Fracchia KM, Walsh C. Metabolic mysteries of the inflammatory response: T cell polarization and plasticity. Int Rev Immunol. 2015 Jan; 34(1):3-18. PMID: 25398050.
      View in: PubMed
    9. Clarke EV, Weist BM, Walsh C, Tenner AJ. Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation. J Leukoc Biol. 2015 Jan; 97(1):147-60. PMID: 25381385; PMCID: PMC4377823.
    10. Weinger JG, Plaisted WC, Maciejewski SM, Lanier LL, Walsh C, Lane TE. Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis. Stem Cells. 2014 Oct; 32(10):2690-701. PMID: 24898518; PMCID: PMC4165828.
    11. Walsh C, Fruman DA. Too much of a good thing: immunodeficiency due to hyperactive PI3K signaling. J Clin Invest. 2014 Sep; 124(9):3688-90. PMID: 25133419; PMCID: PMC4151232.
    12. Lu JV, Chen HC, Walsh C. Necroptotic signaling in adaptive and innate immunity. Semin Cell Dev Biol. 2014 Nov; 35:33-9. PMID: 25042848; PMCID: PMC4197103.
    13. Salvesen GS, Walsh C. Functions of caspase 8: the identified and the mysterious. Semin Immunol. 2014 Jun; 26(3):246-52. PMID: 24856110; PMCID: PMC4099255.
    14. Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh C, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 03; 2(6):825-37. PMID: 24936469; PMCID: PMC4050357.
    15. Walsh C. Grand challenges in cell death and survival: apoptosis vs. necroptosis. Front Cell Dev Biol. 2014; 2:3. PMID: 25364712; PMCID: PMC4206982.
    16. Plaisted WC, Weinger JG, Walsh C, Lane TE. T cell mediated suppression of neurotropic coronavirus replication in neural precursor cells. Virology. 2014 Jan 20; 449:235-43. PMID: 24418558; PMCID: PMC3894587.
    17. Fracchia KM, Pai CY, Walsh C. Modulation of T Cell Metabolism and Function through Calcium Signaling. Front Immunol. 2013 Oct 11; 4:324. PMID: 24133495; PMCID: PMC3795426.
    18. Yang KM, Kim W, Bae E, Gim J, Weist BM, Jung Y, Hyun JS, Hernandez JB, Leem SH, Park T, Jeong J, Walsh C, Kim SJ. DRAK2 participates in a negative feedback loop to control TGF-ß/Smads signaling by binding to type I TGF-ß receptor. Cell Rep. 2012 Nov 29; 2(5):1286-99. PMID: 23122956.
      View in: PubMed
    19. Weinger JG, Weist BM, Plaisted WC, Klaus SM, Walsh C, Lane TE. MHC mismatch results in neural progenitor cell rejection following spinal cord transplantation in a model of viral-induced demyelination. Stem Cells. 2012 Nov; 30(11):2584-95. PMID: 22969049; PMCID: PMC3479361.
    20. Lu JV, Walsh C. Programmed necrosis and autophagy in immune function. Immunol Rev. 2012 Sep; 249(1):205-17. PMID: 22889224; PMCID: PMC4030387.
    21. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
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    22. Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh C. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15312-7. PMID: 21876153; PMCID: PMC3174674.
    23. Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh C. Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol. 2011 Jan 15; 186(2):940-50. PMID: 21148796; PMCID: PMC3133617.
    24. Hernandez JB, Newton RH, Walsh C. Life and death in the thymus--cell death signaling during T cell development. Curr Opin Cell Biol. 2010 Dec; 22(6):865-71. PMID: 20810263; PMCID: PMC2993787.
    25. Walsh C, Edinger AL. The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol Rev. 2010 Jul; 236:95-109. PMID: 20636811; PMCID: PMC2966323.
    26. Walsh C, Bell BD. T cell intrinsic roles of autophagy in promoting adaptive immunity. Curr Opin Immunol. 2010 Jun; 22(3):321-5. PMID: 20392618; PMCID: PMC2891069.
    27. Gatzka M, Newton RH, Walsh C. Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development. J Immunol. 2009 Jul 01; 183(1):285-97. PMID: 19542440; PMCID: PMC2724075.
    28. Bell BD, Walsh C. Coordinate regulation of autophagy and apoptosis in T cells by death effectors: FADD or foundation. Autophagy. 2009 Feb; 5(2):238-40. PMID: 19077534.
      View in: PubMed
    29. Ramos SJ, Hernandez JB, Gatzka M, Walsh C. Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity. J Immunol. 2008 Dec 01; 181(11):7606-16. PMID: 19017949; PMCID: PMC2709975.
    30. Bell BD, Leverrier S, Weist BM, Newton RH, Arechiga AF, Luhrs KA, Morrissette NS, Walsh C. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16677-82. PMID: 18946037; PMCID: PMC2575479.
    31. Al-Qahtani A, Xu Z, Zan H, Walsh C, Casali P. A role for DRAK2 in the germinal center reaction and the antibody response. Autoimmunity. 2008 Aug; 41(5):341-52. PMID: 18568639; PMCID: PMC3140869.
    32. Schaumburg CS, Gatzka M, Walsh C, Lane TE. DRAK2 regulates memory T cell responses following murine coronavirus infection. Autoimmunity. 2007 Nov; 40(7):483-8. PMID: 17966037.
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    33. Arechiga AF, Bell BD, Leverrier S, Weist BM, Porter M, Wu Z, Kanno Y, Ramos SJ, Ong ST, Siegel R, Walsh C. A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2. J Immunol. 2007 Oct 15; 179(8):5291-300. PMID: 17911615.
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    34. Fruman DA, Walsh C. Signal transduction and autoimmunity: introduction. Autoimmunity. 2007 Sep; 40(6):403-4. PMID: 17729032.
      View in: PubMed
    35. Gatzka M, Walsh C. Apoptotic signal transduction and T cell tolerance. Autoimmunity. 2007 Sep; 40(6):442-52. PMID: 17729038.
      View in: PubMed
    36. Ramos SJ, Hardison JL, Stiles LN, Lane TE, Walsh C. Anti-viral effector T cell responses and trafficking are not dependent upon DRAK2 signaling following viral infection of the central nervous system. Autoimmunity. 2007 Feb; 40(1):54-65. PMID: 17364498.
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    37. Friedrich ML, Cui M, Hernandez JB, Weist BM, Andersen HM, Zhang X, Huang L, Walsh C. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. J Biol Chem. 2007 Feb 16; 282(7):4573-84. PMID: 17182616.
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    38. Döskaya M, Kalantari-Dehaghi M, Walsh C, Hiszczynska-Sawicka E, Davies DH, Felgner PL, Larsen LS, Lathrop RH, Hatfield GW, Schulz JR, Gürüz Y, Jurnak F. GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine. Vaccine. 2007 Feb 26; 25(10):1824-37. PMID: 17234306.
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    39. Werner MH, Wu C, Walsh C. Emerging roles for the death adaptor FADD in death receptor avidity and cell cycle regulation. Cell Cycle. 2006 Oct; 5(20):2332-8. PMID: 17102623.
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    40. Choudhary SK, Walker RM, Powell DM, Planelles V, Walsh C, Camerini D. CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection. Virology. 2006 Sep 01; 352(2):268-84. PMID: 16777169.
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    41. Arechiga AF, Bell BD, Solomon JC, Chu IH, Dubois CL, Hall BE, George TC, Coder DM, Walsh C. Cutting edge: FADD is not required for antigen receptor-mediated NF-kappaB activation. J Immunol. 2005 Dec 15; 175(12):7800-4. PMID: 16339514.
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    42. Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh C. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. Int Immunol. 2005 Nov; 17(11):1379-90. PMID: 16172133.
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    43. McGargill MA, Wen BG, Walsh C, Hedrick SM. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity. 2004 Dec; 21(6):781-91. PMID: 15589167; PMCID: PMC2792702.
    44. Ly C, Arechiga AF, Melo JV, Walsh C, Ong ST. Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res. 2003 Sep 15; 63(18):5716-22. PMID: 14522890.
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    45. Walsh C, Luhrs KA, Arechiga AF. The "fuzzy logic" of the death-inducing signaling complex in lymphocytes. J Clin Immunol. 2003 Sep; 23(5):333-53. PMID: 14601642.
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    46. Beisner DR, Chu IH, Arechiga AF, Hedrick SM, Walsh C. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol. 2003 Jul 01; 171(1):247-56. PMID: 12817005.
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